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1.
PLoS One ; 14(12): e0221137, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31877131

RESUMO

The curved planes of the human dentition seen in the sagittal view, the mandibular curve of Spee and the maxillary compensating curve, have clinical importance to modern dentistry and potential relevance to the craniofacial evolution of hominins. However, the mechanism providing the formation of these curved planes is poorly understood. To explore this further, we use a simplified finite element model, consisting of maxillary and mandibular "blocks", developed to simulate tooth eruption, and forces opposing eruption, during simplified masticatory function. We test our hypothesis that curved occlusal planes develop from interplay between tooth eruption, occlusal load, and mandibular movement. Our results indicate that our simulation of rhythmic chewing movement, tooth eruption, and tooth eruption inhibition, applied concurrently, results in a transformation of the contacting maxillary and mandibular block surfaces from flat to curved. The depth of the curvature appears to be dependent on the radius length of the rotating (chewing) movement of the mandibular block. Our results suggest mandibular function and maxillo-mandibular spatial relationship may contribute to the development of human occlusal curvature.


Assuntos
Mandíbula/fisiologia , Erupção Dentária/fisiologia , Dente/fisiologia , Evolução Biológica , Dentição , Análise de Elementos Finitos , Humanos , Mastigação/fisiologia , Maxila/fisiologia
2.
Saudi Med J ; 40(9): 954-957, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31522225

RESUMO

OBJECTIVES: To investigated the diagnostic performance of circumpubertal eruption stages which identify skeletal maturity stages using the cervical vertebral maturation (CVM) method in a Saudi population. METHODS: This is a retrospective cross-sectional study. Lateral cephalograms, panoramic radiographs, and intraoral pictures of 600 orthodontic patients (284 boys, 316 girls) who met inclusion criteria were assessed. Records were retrieved between January 2016 and April 2018. The diagnostic performance of eruption stages for identifying skeletal maturity was tested with positive likelihood ratios (LHR+). RESULTS: Prevalence of each CVM stage in the eruption stages was reported. For every eruption stage, LHR+ was reported in order to identify every CVM stage. The majority of the LHR+ values were ≤3.5, with a significant value of ≥10 for the identification of the post-pubertal growth stage. The other eruptions stages did not strongly predict skeletal maturity. CONCLUSION: In treatment planning for cases that require identifying the growth peak, the use of eruption stages is not recommended as an indicator of skeletal maturity except for the early permanent dentition stage where strong diagnostic performance for identifying post-pubertal skeletal growth stage has been shown.


Assuntos
Determinação da Idade pelo Esqueleto/métodos , Desenvolvimento Ósseo/fisiologia , Vértebras Cervicais/diagnóstico por imagem , Dentição Permanente , Erupção Dentária/fisiologia , Adolescente , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Ortodontia Corretiva/métodos , Radiografia Panorâmica , Estudos Retrospectivos
3.
Niger J Clin Pract ; 22(7): 936-942, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31293258

RESUMO

Aim: The high incidence of caries in first permanent molars (FPMs) makes premature extraction of these teeth common. The extraction of the permanent teeth results in various changes in the dental arch. The aim of this study was to evaluate space closure, the eruption of second permanent molars (SPMs), and changes in dental arch after extraction of the FPMs. Materials and Methods: Eruption of 83 SPMs was recorded and radiographically developmental stage of these SPMs in the pre-extraction panoramic radiograph was assessed. Space was measured between the distal surface of the second premolar and the mesial surface of SPM. Results: Out of 55 patients, 28 (50.9%) were males and 27 (49.1%) were females. Thirty-seven (44.6%) of 83 teeth belonged to category 1, 17 (20.5%) teeth belonged to category 2, and 5 (6.02%) teeth belonged to category 3. Although category 4 was not found, 24 (28.9%) teeth were observed to be in category 5. Out of all SPMs, 10.8% represented the ''ideal'' stage of Demirjian's dental development, stage E. Conclusion: In patients who had the FPMs extracted before the eruption of the SPM, it is important with regards to the patients' comfort and health to review the patient regularly and to determine any need for orthodontic treatment.


Assuntos
Mineração de Dados , Arco Dental , Cárie Dentária/cirurgia , Dente Molar/cirurgia , Erupção Dentária/fisiologia , Extração Dentária/métodos , Adolescente , Dente Pré-Molar , Criança , Cárie Dentária/epidemiologia , Dentição Permanente , Feminino , Humanos , Incidência , Masculino , Radiografia Panorâmica , Turquia/epidemiologia
4.
J Mol Histol ; 50(5): 427-434, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31270650

RESUMO

The accurately establishment of the eruptive pathway is of vital importance. The mechanisms governing tooth eruption pathway remain little known. This study is to elucidate the roles of Semaphorin 3A (Sema 3A) in mouse tooth eruptive pathway. C57BL/6 mice (11-13 and 15-17 days after birth) were chosen to observe eruptive pathway of mouse lower first molar. Expressions of Sema 3A and its receptor neuropilin 1 and plexin A1 were detected. Osteoclasts were identified by TRAP staining. Co-localization of Sema 3A and osteoclast maker CD68 was detected by double immunofluorescence staining. Picrosirius red staining was applied to observe collagen fibers during mucosal penetration phase. In vitro, Bone marrow-derived macrophages (BMMs) were prepared from 4 week C57BL/6 mice to observe the effect of Sema 3A on the differentiation of BMMs into osteoclasts by TRAP staining. Expressions of Sema 3A was observed by immunofluorescence and western blotting. At osseous eruption phase, many TRAP-positive multi-nucleated cells were distributed around occlusal alveolar bone. The positive expressions of Sema 3A were observed in the multi-nucleated cells. Fluorescence double staining showed that Sema 3A and CD68 were co-expressed in osteoclasts. Its receptor neuropilin 1 and plexin A1 were also found in osteoclasts. In vitro, Sema3A negatively regulated osteoclast differentiation. At mucosal penetration, occlusal alveolar bone had been completely resorbed and collagen fires were gradually degraded for eruptive pathway. Similar positive expressions of Sema 3A and its receptor neuropilin 1 and plexin A1 were also found in the mucosal penetration pathway. Sema 3A gets involved in the establishment of mouse tooth eruptive pathway by modulating osteoclast activity. Sema3A should be considered as a novel nervous agent or a potential biomarker for mouse tooth eruptive pathway.


Assuntos
Osteoclastos/metabolismo , Semaforina-3A/fisiologia , Erupção Dentária/fisiologia , Animais , Osso e Ossos/metabolismo , Diferenciação Celular , Colágeno/metabolismo , Macrófagos , Camundongos , Camundongos Endogâmicos C57BL , Dente Molar/fisiologia , Neuropilina-1/metabolismo , Semaforina-3A/metabolismo
5.
Acta Medica (Hradec Kralove) ; 62(2): 62-68, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31184300

RESUMO

The aim of this research is to study the effect of body overweight at birth (fetal macrosomia) on the processes of tooth eruption and tooth growth during the first year of life in children in the Kharkiv City (Ukraine) population. One of the research tasks is to examine the features of deciduous teeth eruption in children who were born with macrosomia with different values of the weight-height index at birth. Materials and methods. The medical records of the children born between 1977 and 2013 have been analyzed. The database has been collected in one of the Kharkiv City clinic. The Main Group is comprised of the medical records of the children (separately for boys and girls) born with fetal macrosomia. All the medical records of the Main Group have been divided into subgroups taking into account the gender and the harmonious (well-balanced) development coefficient. The Comparison Group is comprised of the medical records of the children also born within the normal term range, but with weight and height that correspond to the gestation age (fetal normosomia). To determine the average time of the first tooth eruption, as well as the deciduous teeth growth rate for each of the groups under the study, we have used the hypothesis about a linear dependence between the number of erupted teeth and the age of the child. The statistical data processing and verification of the consistency of this hypothesis is performed using the multiple linear regression analysis with the STATISTICA 6.0 software package (Multiple Regression module). The number of delayed eruption and premature eruption cases observed is calculated along with the corresponding confidence intervals for the significance level, p, of less than 0.05, taking into account the binomial distribution of the random variable. The results of the study indicate a slowed growth rate of deciduous teeth in children born with macrosomia, as well as an increased number of cases (by a factor of 2 to 4 times) of deviations in the timing of teeth eruption compared to regional norms. The smallest growth rate of deciduous teeth and the smallest number of teeth at the age of one year are registered in macrosomic boys and macrosomic girls with a long body and a relatively reduced birth weight, as well as in macrosomic girls with intrauterine obesity. The macrosomic girls with intrauterine acceleration with obesity at the background have the largest average tooth growth rate and the largest percentage of premature eruption cases among all subgroups. Conclusions. The somatometric features of fetal macrosomia suggest the influence on the number of teeth that erupt by a certain age. The data on the deviation from the generally accepted terms of teeth eruption in children born with macrosomia, can be the basis for developing new and improving existing prevention programs aimed at preserving dental health.


Assuntos
Peso ao Nascer , Estatura , Macrossomia Fetal/fisiopatologia , Erupção Dentária/fisiologia , Dente Decíduo/crescimento & desenvolvimento , Feminino , Macrossomia Fetal/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Ucrânia/epidemiologia
6.
J Appl Oral Sci ; 27: e20180276, 2019 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-31116278

RESUMO

OBJECTIVE: The aim of this study was to investigate possible malformations in the soft, bone and/or dental tissues in patients with congenital Zika Virus (ZIKV) by clinical and x-ray evaluation. METHODOLOGY: Thirty children born with ZIKV and 30 children born without ZIKV (control group) were included in the study. Patients were evaluated over 24 consecutive months according to the variables: sex, age, cleft palates, soft tissue lesions, alveolar ridge hyperplasia, short labial and lingual frenums, inadequate posture of the lingual and perioral muscles at rest, micrognathia, narrow palatine vaults, changes in the teeth shape and/or number, sequence eruption, spasms, seizures and eruption delay were evaluated. Chi-square test, Student's t-test and nominal logistic regression were used (p<0.05). RESULTS: Among the 30 babies examined, the mean age of the first dental eruption was 10.8±3.8 with almost two-thirds of the children (n=18, 60%) experiencing eruptions of their first tooth after 9 months of age, nine children (30%) had inadequate lingual posture at rest, more than half of the children (n=18, 60%) had short labial or lingual frenums. ZIKV babies showed a high prevalence of clef palate (p<0.001), inadequate lingual posture at rest (p=0.004), micrognathia (p=0.002), changes in the shape and/or number of teeth (p=0.006), alteration in sequence of dental eruption (p<0.001) and muscles spasms (p=0.002). The delay eruption was associated with inadequate lingual posture at rest (p=0.047), micrognathia (p=0.002) and changes in the shape and/or number of teeth (p=0.021). The delayed eruption (p=0.006) and narrow palatine vaults (p=0.008) were independently associated with ZIKV. Moreover, female patients showed the most narrow palatine vaults (p=0.010). CONCLUSIONS: The children with ZIKV showed a greater tendency to have delayed eruption of the first deciduous tooth, inadequate lingual posture and short labial and lingual frenums.


Assuntos
Anormalidades Dentárias/patologia , Anormalidades Dentárias/virologia , Infecção por Zika virus/congênito , Fatores Etários , Estudos de Casos e Controles , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Freio Labial/anormalidades , Freio Lingual/anormalidades , Modelos Logísticos , Masculino , Microcefalia/patologia , Microcefalia/fisiopatologia , Microcefalia/virologia , Análise Multivariada , Radiografia Dentária , Fatores de Tempo , Anormalidades Dentárias/diagnóstico por imagem , Anormalidades Dentárias/fisiopatologia , Erupção Dentária/fisiologia , Infecção por Zika virus/fisiopatologia
7.
Forensic Sci Int ; 300: 63-74, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31075568

RESUMO

OBJECTIVE: To investigate a potential delay in dental development in cleft patients compared with non-cleft patients. SEARCH METHODS: An unlimited electronic search was performed in four databases (PubMed, Embase, Lilacs and OpenGrey), from inception until October 2018. Full text articles concerning dental development or tooth eruption of non-syndromic children with cleft lip and/or palate (CL(P)) were included and reviewed. Case reports/series, review articles, articles in languages other than English, Dutch, French or Spanish and studies considering the eruption of deciduous teeth were excluded. Data extraction followed the PRISMA guidelines and study quality was assessed using MINORS. RESULTS: The primary search resulted in 991 citations, of which 36 studies were finally analyzed. Most articles were retrospective studies based on panoramic radiographs. A delay in tooth development or -eruption in CL(P) patients was found in 32 out of the 36 included articles. The amount of delay varied from 0.20 to 0.90 years, with a mean delay of 0.56 years for all types of clefts. In UCLP patients, a mean delay of 0.53 years was found. The lateral incisor at the cleft side was generally the most delayed. Conflicting results were found regarding the influence of sex and age. The amount of delay was reported to be independent of the cleft severity or type. The teeth near the cleft generally showed a greater delay than the teeth further away from it. Finally, an increased risk of asymmetrical tooth development in CL(P) patients was observed in all publications studying this aspect. 31 articles were comparative, 5 were non-comparative; with a median MINORS score of 16/24 (range 10-18) and 10/16 (range 8-10) for both groups respectively. CONCLUSIONS: The majority of the included articles reports a delay in dental development or tooth eruption in CL(P) patients compared to non-CL(P) patients. The obtained results could be important for forensic age estimation outcomes and for orthodontic and surgical treatment planning in CL(P) patients. The delay in tooth development implies a delay in start of orthodontic treatment. Moreover, CL(P) patients could falsely be considered to be a minor when applying the existing reference tables for dental age estimation. SYSTEMATIC REVIEW REGISTRATION: International prospective register of systematic reviews (PROSPERO: CRD42018082106).


Assuntos
Fenda Labial/fisiopatologia , Fissura Palatina/fisiopatologia , Erupção Dentária/fisiologia , Dente/crescimento & desenvolvimento , Humanos , Anormalidades Dentárias/fisiopatologia
8.
Anat Sci Int ; 94(1): 136-143, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30229540

RESUMO

A major component of tooth innervation is made of capsaicin-sensitive primary afferents (CSPA). These fibers play a key role in tooth pain and inflammation; little is known, however, about the role of CSPA in tooth eruption. The aim of this study was to examine the role of the capsaicin-sensitive afferents in the process of eruption of intact rat incisors. CSPA fibers in several rat groups, were subjected to one of the following experimental procedures: systemic chemical ablation, systemic ablation followed by chemical sympathectomy and localized activation. The observed effects on incisor eruption were compared to those made on controls. The total amount of eruption in control/naïve rats, measured over a total period of 144 h, was 3.18 ± 0.07 mm and decreased to 2.43 ± 0.08 mm (n = 7; p < 0.001) following systemic ablation of CSPA. Further decrease to 2.24 ± 0.08 mm (n = 7; p < 0.001) was noticed when chemical sympathectomy was added to CSPA ablation. The average rate of eruption was 1.7 ± 0.25 mm following CSPA activation, compared to an average of 0.8 ± 0.07 mm for controls (n = 7; p < 0.001). Capsaicin sensitive fibers play an important role in tooth homeostasis, and intact neural supply is required for tooth growth under normal conditions.


Assuntos
Processo Alveolar/inervação , Capsaicina/metabolismo , Incisivo/inervação , Mandíbula/inervação , Erupção Dentária/fisiologia , Vias Aferentes/fisiologia , Animais , Masculino , Modelos Animais , Ratos , Ratos Sprague-Dawley
9.
Congenit Anom (Kyoto) ; 59(1): 11-17, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29691907

RESUMO

Turner syndrome is associated with an X chromosome abnormality in women and is characterized by infantilism, congenital webbed neck, and cubitus valgus. The aim of this study was to determine the maxillofacial morphology and oral characteristics of Japanese girls (mean age, 8.5 years) with Turner syndrome and early mixed dentition. Lateral cephalograms obtained at the first visit were used to analyze maxillofacial morphology. Oral characteristics were identified using orthopantomograms, intraoral photographs, and study casts. All patients received growth hormone. Lateral cephalograms showed a retrognathic maxilla and mandible and a small gonial angle. Nine patients had a high-arched palate. Nine patients had class II first molar relationship occlusion and one had mesial step-type occlusion. Three patients showed ectopic eruption of the maxillary first permanent molar accompanied by resorption of the maxillary second primary molar. Eruption of the permanent teeth tended to occur early. The median mesiodistal diameter of the maxillary central incisor was smaller than the Japanese norm. Ectopic eruption of the maxillary first permanent molar may be caused by lack of eruption space and a discrepancy between bone growth and timing of tooth maturation.


Assuntos
Arco Dental/patologia , Face/anormalidades , Mandíbula/anormalidades , Maxila/anormalidades , Síndrome de Turner/patologia , Cefalometria , Criança , Arco Dental/diagnóstico por imagem , Dentição Mista , Face/diagnóstico por imagem , Feminino , Hormônio do Crescimento/uso terapêutico , Humanos , Incisivo/anormalidades , Incisivo/diagnóstico por imagem , Cariótipo , Má Oclusão/diagnóstico por imagem , Má Oclusão/patologia , Mandíbula/diagnóstico por imagem , Maxila/diagnóstico por imagem , Dente Molar/anormalidades , Dente Molar/diagnóstico por imagem , Radiografia Panorâmica , Erupção Dentária/fisiologia , Síndrome de Turner/diagnóstico por imagem , Síndrome de Turner/tratamento farmacológico , Síndrome de Turner/genética
10.
Int J Paediatr Dent ; 29(1): 74-78, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30302841

RESUMO

BACKGROUND: The eruption of primary teeth represents a stage of many challenges for parents. AIM: To investigate the occurrence of signs and symptoms related to the eruption of the primary dentition in children with congenital Zika syndrome. DESIGN: Longitudinal study developed with 79 children followed up for a period of 24 months. Data on sex, gestational age, low birthweight, microcephaly, signs and symptoms related to the dental eruption phase, and use and type of medication were collected. Data were presented by descriptive and inferential statistics (chi-square test). RESULTS: The majority (94.9%) exhibited simultaneously two or more signs and symptoms related to dental eruption. Increased salivation (91.1%), irritability (86.1%), and gingival itching (83.5%) were the most commonly reported signs and symptoms. Bivariate analysis showed association between elevation of body temperature and sex (P < 0.05). Almost two-thirds of mothers (63.3%) reported using medication to relieve symptoms presented by the child; however, the use of topical medication prevailed (57.1%). CONCLUSION: All children with congenital Zika syndrome presented manifestations related to the eruption of primary teeth, with increased salivation, irritability, and gingival pruritus. The use of ointments and gels was the option of mothers in the treatment of the oral discomfort presented by infants.


Assuntos
Erupção Dentária/fisiologia , Infecção por Zika virus/congênito , Criança , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Masculino , Infecção por Zika virus/fisiopatologia
11.
Proc Natl Acad Sci U S A ; 116(2): 575-580, 2019 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-30509999

RESUMO

Formation of functional skeletal tissues requires highly organized steps of mesenchymal progenitor cell differentiation. The dental follicle (DF) surrounding the developing tooth harbors mesenchymal progenitor cells for various differentiated cells constituting the tooth root-bone interface and coordinates tooth eruption in a manner dependent on signaling by parathyroid hormone-related peptide (PTHrP) and the PTH/PTHrP receptor (PPR). However, the identity of mesenchymal progenitor cells in the DF and how they are regulated by PTHrP-PPR signaling remain unknown. Here, we show that the PTHrP-PPR autocrine signal maintains physiological cell fates of DF mesenchymal progenitor cells to establish the functional periodontal attachment apparatus and orchestrates tooth eruption. A single-cell RNA-seq analysis revealed cellular heterogeneity of PTHrP+ cells, wherein PTHrP+ DF subpopulations abundantly express PPR. Cell lineage analysis using tamoxifen-inducible PTHrP-creER mice revealed that PTHrP+ DF cells differentiate into cementoblasts on the acellular cementum, periodontal ligament cells, and alveolar cryptal bone osteoblasts during tooth root formation. PPR deficiency induced a cell fate shift of PTHrP+ DF mesenchymal progenitor cells to nonphysiological cementoblast-like cells precociously forming the cellular cementum on the root surface associated with up-regulation of Mef2c and matrix proteins, resulting in loss of the proper periodontal attachment apparatus and primary failure of tooth eruption, closely resembling human genetic conditions caused by PPR mutations. These findings reveal a unique mechanism whereby proper cell fates of mesenchymal progenitor cells are tightly maintained by an autocrine system mediated by PTHrP-PPR signaling to achieve functional formation of skeletal tissues.


Assuntos
Comunicação Autócrina/fisiologia , Células-Tronco Mesenquimais/metabolismo , Proteína Relacionada ao Hormônio Paratireóideo/genética , Receptor Tipo 1 de Hormônio Paratireóideo/metabolismo , Transdução de Sinais/fisiologia , Erupção Dentária/fisiologia , Animais , Diferenciação Celular/fisiologia , Saco Dentário/citologia , Saco Dentário/metabolismo , Humanos , Células-Tronco Mesenquimais/citologia , Camundongos , Camundongos Transgênicos , Proteína Relacionada ao Hormônio Paratireóideo/metabolismo , Receptor Tipo 1 de Hormônio Paratireóideo/genética
12.
Indian J Dent Res ; 29(6): 726-731, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30588999

RESUMO

Context: Eruption of first primary teeth is the most anxiously awaited developmental milestone in a child. However, primary teeth have shown wide variations in their eruption time among different population, ethnic, and racial groups. Aims: The present study was conducted with the aim to evaluate the time and sequence of eruption of primary teeth of children of Mysore. Settings and Design: A cross-sectional study design included 1392 participants aged 3 months to 36 months recruited by simple random sampling method. The variables such as age, gender, and number of erupted primary teeth were recorded. Subjects and Methods: Clinical examination was done under natural illumination. A tooth was considered erupted when any part of its crown had penetrated the gingiva and was visible in the oral cavity. Statistical Analysis Used: Probit regression analysis was performed to obtain the mean and median age of eruption of teeth. The significance of difference in the mean age of eruption across gender and arch was determined using paired t-test. Results and Conclusion: The first primary tooth to erupt was mandibular central incisor at 10.24 ± 2.47 months followed by maxillary central incisor at 11.06 ± 2.65 months. The duration of primary teeth eruption was 17.89 and 18.32 months in males, 18.54 months and 18.32 months in females for maxilla and mandible, respectively. Eruption of primary tooth is delayed among children of Mysore as compared to standard eruption chart. The results will provide information to health professional about contemporary tooth eruption time derived from an Indian population.


Assuntos
Erupção Dentária/fisiologia , Dente Decíduo/fisiologia , Fatores Etários , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Índia , Lactente , Masculino
13.
Braz Dent J ; 29(5): 465-468, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30517445

RESUMO

The aim of this study was to evaluate the association between timing of permanent tooth emergence with overweight and obesity in children from Brazilian Amazon region. The studied population consisted of 192 children, 09 to 12 year-old, from public schools at Manaus, Amazonas-Brazil. Clinical examination was performed and the tooth emergence was evaluated according to the number of permanent erupted teeth. Body mass index z-score was calculated. For the statistical analysis 'Overweight/obese' group was compared with 'Normal weight' group in a case to control ratio 1:2. The t-test based on age was used for means comparison between the groups. A linear regression analysis using age and gender as co-variants was used. The established alpha was 5%. One hundred twenty-seven children were classified as normal weight and 65 were classified as overweight/obese (49 were overweight and 16 were obese). Overweight/obesity condition was associated with the gender, in which boys had a higher chance to present higher weight conditions (OR=1.84; CI 95% 1.06-3.37; p=0.04). The mean number of permanent teeth was higher in the overweight/obesity group (p<0.001). Linear regression analysis demonstrated that nutritional status, gender and age were strongly associated with number of permanent erupted teeth (p<0.05). In conclusion, our study demonstrated that timing of permanent tooth emergence is associated with overweigh/obesity in children from Manaus, Brazil.


Assuntos
Dentição Permanente , Sobrepeso/fisiopatologia , Obesidade Pediátrica/fisiopatologia , Erupção Dentária/fisiologia , Índice de Massa Corporal , Brasil , Criança , Feminino , Humanos , Masculino
14.
Arch Oral Biol ; 96: 195-200, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30292055

RESUMO

The alveolar bone has a unique capacity to follow the teeth's movements. It is formed around erupting teeth and their periodontal ligaments: the more the teeth have erupted, the larger the alveolar process. Throughout life the teeth erupt and migrate in an occlusal and mesial direction to compensate for attrition, an evolutionary trait. After tooth extraction, the alveolar process is resorbed to varying degrees. The mandibular alveolar bone mirrors skeletal bone condition. Due to fast bone turnover (which is the fastest in the whole skeleton), low bone mass and increased fracture risk may first be seen here. If a periapical radiograph of the mandibular premolars shows a dense trabeculation with well-mineralized trabeculae and small intertrabecular spaces, it is a reliable sign of normal skeletal bone density (BMD) and low skeletal fracture risk, whereas a sparse trabecular pattern indicates osteopenia and high fracture risk. The bone turnover rate in the mandible is twice that of the maxilla, and may, hypothetically, play a role in the development of osteonecrosis of the jaw (ONJ), which has been found mainly in the mandibular alveolar process?


Assuntos
Processo Alveolar/fisiologia , Mandíbula/fisiologia , Processo Alveolar/metabolismo , Animais , Biomarcadores/metabolismo , Fenômenos Biomecânicos/fisiologia , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/fisiopatologia , Densidade Óssea/fisiologia , Remodelação Óssea/fisiologia , Humanos , Mandíbula/metabolismo , Osteoporose/fisiopatologia , Erupção Dentária/fisiologia , Extração Dentária , Técnicas de Movimentação Dentária
15.
Bull Tokyo Dent Coll ; 59(4): 277-284, 2018 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-30333373

RESUMO

The aim of this study was to obtain basic data that might serve as criteria in the diagnosis of delayed eruption of the permanent teeth. The synchronicity of the eruption of corresponding contralateral teeth was determined. Data were obtained on both the deciduous and permanent dentition based on records made every 2 months at the Department of Pediatric Dentistry of Tokyo Dental College. These data were then used to investigate bilateral differences in the timing of eruption of the permanent teeth. Over 80% of incisors, first molars, mandibular canines, and maxillary first premolars erupted within 4 months of their contralateral counterparts, while this occurred in 75% of maxillary canines, mandibular first premolars, and mandibular second molars, 70% of maxillary and mandibular second premolars, and 65% of maxillary second molars. Bilateral differences in the timing of permanent tooth eruption varied depending on type of tooth, and these differences tended to be smaller for teeth erupting at an earlier point in the order of eruption, and greater for those erupting at a later point. These results suggest that the failure of a contralateral tooth to erupt within 4 months of its counterpart might serve as a criterion in a diagnosis of suspected delayed eruption of a permanent tooth.


Assuntos
Dentição Permanente , Erupção Dentária/fisiologia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Feminino , Humanos , Incisivo , Masculino , Desenvolvimento Maxilofacial , Valores de Referência , Fatores Sexuais , Fatores de Tempo , Tóquio , Adulto Jovem
16.
Am J Phys Anthropol ; 167(4): 827-839, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30281775

RESUMO

OBJECTIVES: This study investigates mean age, sequence, and temporal trends of permanent tooth emergence in Black Southern African children and compares the findings with other population samples. MATERIALS AND METHODS: This community-based cross-sectional study involved 639 Black Southern African children between 5 and 20 years of age. Probit analysis was used to derive the mean age at emergence of the permanent teeth. Sex and cross-population comparisons were undertaken to determine similarities and differences in emergence timing and sequence. RESULTS: Females emerged all teeth earlier except for M3s (p < .05). Black Southern Africans have earlier mean ages of emergence compared to population samples from the USA, Europe, Australia, and Asia. Sexual dimorphism was detected in the mandibular I1/M1 emergence sequence (females, M1 I1 ; males, I1 M1 ). The sequence in males is similar in both jaws to males from other sub-Saharan African, USA, and European samples. Females show a similar sequence pattern in the maxilla with other sub-Saharan African, and also Australian and US females of European ancestry. There is a high frequency of polymorphism in the P1P2C1 emergence sequence, with significantly more P2P1C1 maxillary sequences seen among males. Polymorphic variation was common for the I1 M1 sequence in both males and females. DISCUSSION: Mean age of tooth emergence among Black Southern African children is similar to children from most other sub-Saharan African populations. No temporal change was seen in the mean age of emergence. Earlier permanent tooth emergence in Black Southern Africans is part of a general sub-Saharan pattern that is distinct from European and Asian populations.


Assuntos
Grupo com Ancestrais do Continente Africano/estatística & dados numéricos , Erupção Dentária/fisiologia , Adolescente , Adulto , África Austral/epidemiologia , Antropologia Física , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Caracteres Sexuais , Fatores de Tempo , Adulto Jovem
17.
Rom J Morphol Embryol ; 59(2): 491-497, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30173253

RESUMO

The purpose of this study is to determine the cephalic and facial morphological typology in prepubertal children from Timisoara (Romania) and to develop a population-specific reference for the dental eruption of permanent teeth in the supporting zone of the dentition, in relation to the facial morphological typology. Using cephalic and facial indexes in a group of 234 preadolescents with mixed dentition, we quantified morphological associations between cephalic and facial types, using a cross-sectional design. The prepubertal children in Timisoara have a dominant mesoprosopic facial type and mesocephalic type. For supporting zone of the dentition, the presence of permanent teeth, the canine, the first premolar and the second premolar was recorded, for all four quadrants. Dental eruption in the supporting zone of the dentition has particularities depending on population group, gender, dental arch, but also facial type. From the data of this study, the following patterns of eruption, specific to each facial type, have resulted: for leptoprosopic facial type - first upper premolar (UP1), second upper premolar (UP2), upper canine (UC)∕first lower premolar (LP1), lower canine (LC), second lower premolar (LP2); for mesoprosopic facial type - UP1, UP2, UC∕LC, LP1, LP2; and for euryprosopic facial type - UP1, UP2, UC∕LC, LP1, LP2. The leptoprosopic and euryprosopic facial types have a delayed and accelerated eruption compared to the mesoprosopic facial type. The euryprosopic facial type has more intense mandibular eruption. The leptoprosopic facial type registers the largest percentage of children requiring orthodontic treatment. Monitoring the sequence of eruption of the permanent teeth is very important to ensure the balanced development of the dental occlusion, mandible and facies as a whole.


Assuntos
Dentição Permanente , Erupção Dentária/fisiologia , Fatores Etários , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Romênia
18.
Am J Phys Anthropol ; 167(2): 217-233, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30216408

RESUMO

OBJECTIVES: Although a great deal is known about the biology of tooth development and eruption, there remains disagreement about the factors driving the evolution of dental eruption sequence. We assessed postcanine eruption sequence across a large sample of primates to test two hypotheses: (1) Dental eruption sequence is significantly correlated with life history and body size variables that capture postnatal growth and longevity (Schultz's Rule), and (2) Dental eruption sequence is conserved phylogenetically. MATERIALS AND METHODS: We assessed postcanine dental eruption sequence for 194 individuals representing 21 primate genera spanning eight families. With the inclusion of an additional 29 primate genera from the literature, this is the most comprehensive report on dental eruption sequence in primates to date. We used a series of phylogenetic analyses to statistically compare dental eruption sequence to life history and body size and test for phylogenetic signal in these traits. RESULTS: Dental eruption sequence is conserved phylogenetically in primates, and body and brain size are both significantly associated with dental eruption sequence. Ancestral state reconstruction supports the hypothesis that the third molar erupted before one or more of the premolars in the ancestor of primates and derived clades within primates evolved an eruption sequence in which the third molar erupts after the premolars. DISCUSSION: Schultz's Rule, as it is currently written and applied, is not supported by this extended data set. Our results demonstrate that dental eruption sequence is a far better predictor of phylogeny and will likely prove useful in phylogenetic hypotheses about relationships between extinct and extant mammalian taxa. The evolution of dental eruption sequence is likely driven by factors that significantly influence body size and mandibular symphyseal fusion.


Assuntos
Primatas/classificação , Primatas/fisiologia , Erupção Dentária/fisiologia , Animais , Tamanho Corporal/genética , Tamanho Corporal/fisiologia , Feminino , Masculino , Mandíbula/anatomia & histologia , Mandíbula/fisiologia , Filogenia , Primatas/genética , Erupção Dentária/genética
19.
Eur J Oral Sci ; 126 Suppl 1: 72-80, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30178560

RESUMO

The principles of formation, renewal, and eruption of teeth are discussed. Numerous genetic aberrations may affect the formation and eruption of teeth. Cleidocranial dysplasia (CCD), caused by mutations in the runt-related transcription factor 2 (RUNX2) gene, is such a condition. The dental phenotype includes problems in both tooth formation (multiple supernumerary permanent teeth) and tooth eruption (lack of shedding of primary teeth and delayed or arrested eruption of permanent teeth). Clinical studies, animal models, and molecular biology studies have documented that RUNX2 is of paramount importance for osteoblast differentiation, for regression of the dental lamina, and for osteoclastogenesis in the dental follicle and the periodontal ligament. Jensen & Kreiborg, 25 yr ago, proposed a treatment strategy to be applied to patients with CCD, focussing on the importance of early treatment to promote spontaneous eruption of permanent teeth through extraction of primary teeth, surgical removal of supernumerary teeth, and removal of bone covering the first formed permanent teeth at the time when root formation of the permanent teeth has reached half or two-thirds of their final length. This strategy still seems valid and seems to lead to reduction in the burden of care for patients compared with the treatment protocols otherwise recommended.


Assuntos
Displasia Cleidocraniana/patologia , Erupção Dentária , Dente/crescimento & desenvolvimento , Displasia Cleidocraniana/diagnóstico por imagem , Displasia Cleidocraniana/fisiopatologia , Humanos , Radiografia Panorâmica , Erupção Dentária/fisiologia
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