Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 720
Filtrar
1.
Braz Oral Res ; 33: e094, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31618294

RESUMO

This study aimed to analyze the association of sociodemographic, child health, healthcare service, and access indicators with developmental defects of enamel (DDE) acquired outside the uterus, based on gestational factors. A cohort of births was carried out, and 982 children aged 12 to 30 months were examined. A total of 1,500 women were followed up as of the 5th month of gestation, and the child's gestational age was evaluated at follow-up. The clinical examination was performed as recommended by the World Health Organization, and defects were classified using the modified DDE index. Six models were considered: presence of DDE (Model 1) or opacities (Model 4), number of teeth with DDE (Model 2) or opacities (Model 5), and incidence rate of DDE (Model 3) or opacities (Model 6). Associations were estimated by relative risk (RR) in Poisson regression models. In the adjusted analysis, the mother's lowest education level was associated with the highest occurrence of DDE in Models 1 (RR = 26.43; p = 0.002), 2 (RR = 9.70; p = 0.009), and 3 (RR = 5.63; p = 0.047). Breastfeeding for over 12 months (RR = 0.45; p = 0.030) and recent use of anti-infection drugs (RR = 0.20; p = 0.039) had a protective effect on DDE (Model 1). The factors associated with the highest incidence of opacities were not having health insurance (RR = 2.00; p = 0.043) (Model 5), and belonging to a family of poor social class (RR = 4.67; p = 0.007) (Model 6). Children in a situation of socioeconomic vulnerability have a higher risk of presenting extrauterine DDE. Breastfeeding was a protection factor for DDE development.


Assuntos
Hipoplasia do Esmalte Dentário/epidemiologia , Hipoplasia do Esmalte Dentário/etiologia , Esmalte Dentário/anormalidades , Brasil/epidemiologia , Aleitamento Materno , Pré-Escolar , Hipoplasia do Esmalte Dentário/prevenção & controle , Feminino , Idade Gestacional , Acesso aos Serviços de Saúde/estatística & dados numéricos , Humanos , Incidência , Lactente , Masculino , Modelos Teóricos , Estudos Prospectivos , Análise de Regressão , Medição de Risco , Fatores de Risco , Fatores Socioeconômicos , Populações Vulneráveis
2.
Niger J Clin Pract ; 22(8): 1157-1162, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31417061

RESUMO

Background: The aims of this study are to present sociodemographic and familial characteristics, clinical and systemic findings, dental treatment needs, and concomitant dental anomalies in patients with amelogenesis imperfecta (AI) and to evaluate time-varying conditions in these long-term follow-up patients. Materials and Methods: Records of patients with AI who were examined in the Department of Pediatric Dentistry between 1999 and 2017 were reviewed. Information about sociodemographic characteristics, history of AI and consanguinity in family, systemic conditions, reasons for referral to the clinic, oral hygiene habits and gingival health, occlusion findings, and performed treatments were gathered. Dental anomalies in radiographs were also evaluated. Baseline and final situations of the patients were assessed. Statistical analyses were performed. Results: Of 75 patients aged 3-15 years with follow-ups up to 12 years, 34 had AI in their families and 15 were born from consanguineous marriages. Nephrocalcinosis has been observed in 5 patients. Main reasons for referral to the clinic were related to esthetic and hypersensitivity concerns. Twenty-two patients had gingivitis, and during follow-up process, gingival problems could not be completely prevented due to poor oral hygiene habits. Vertical dimension loss, open-bite, and cross-bite were seen in 16, 15, and 10 patients, respectively. Of the patients, 63% experienced restorative, 33% stainless steel crown, 17% endodontic, 8% prosthetic treatments, and 24% had retreatment needs. Concomitant dental anomalies were dens invaginatus, taurodontism, ectopic eruption, delayed eruption, hypodontia, and pulpal calcification. Conclusion: Early diagnosis and interventions considering the time-varying conditions with long-term follow-ups provide significant improvements in clinical maintenance of patients with AI.


Assuntos
Amelogênese Imperfeita/diagnóstico por imagem , Amelogênese Imperfeita/terapia , Esmalte Dentário/anormalidades , Reabilitação Bucal/métodos , Radiografia Panorâmica , Adolescente , Amelogênese Imperfeita/genética , Criança , Pré-Escolar , Cárie Dentária/terapia , Sensibilidade da Dentina/epidemiologia , Sensibilidade da Dentina/terapia , Estética Dentária , Feminino , Gengivite/epidemiologia , Humanos , Masculino , Má Oclusão , Nefrocalcinose/epidemiologia , Nefrocalcinose/terapia , Índice de Higiene Oral , Aço Inoxidável
3.
Arch Oral Biol ; 104: 1-6, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31151029

RESUMO

OBJECTIVE: The staircase (Sc) pattern enamel microstructure is an expression of an impaired ameloblast function. It has been reported to appear in the neonatal line (NNL), the accentuated stria evincing live birth in deciduous tooth enamel. Our objective was to investigate the prevalence of Sc NNL in deciduous tooth types and its possible association with perinatal circumstances. DESIGN: Sc in the NNL of 88 teeth, a collection derived from a long-term, prospectively followed population cohort, was recorded with linear polarised transmitted light and analysed for tooth type, duration and mode of delivery, and pain medication used during labour. RESULTS: Sc prevalence in the NNL differed highly significantly between tooth types (p < 0.0001). An increase in Sc prevalence was significantly associated with an increased ratio of prenatal to total crown enamel (p < 0.001), when buccal and lingual crown walls were analysed separately. No significant association was found between Sc prevalence and duration or mode of delivery or pain-relieving medication (p = 0.57, p = 0.65, p = 0.58, respectively). CONCLUSION: This research indicates that the NNL location within tooth crown enamel has a strong impact on microstructural changes along the NNL. Considering our results of Sc prevalence, deciduous canines, having the least Sc appearance, could be used in studies that aim to investigate factors associated with NNL width. In addition, Sc prevalence variation in first deciduous molars might enable to investigation of physiological stressors strong enough to cause ameloblast impairment, such as Sc.


Assuntos
Esmalte Dentário , Dente Decíduo , Estudos de Coortes , Esmalte Dentário/anormalidades , Feminino , Humanos , Recém-Nascido , Dente Molar , Gravidez , Prevalência , Dente Decíduo/anormalidades
4.
Pediatr Dent ; 41(2): 95-112, 2019 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-30992106

RESUMO

Purpose: The purpose of this study was to perform a systematic review to assess current evidence for association between various risk factors and the prevalence or incidence of early childhood caries (ECC). Methods: Two reviewers searched various databases until January 2019. The Newcastle-Ottawa scale was used to perform risk of bias assessment. The included studies were categorized according to the World Bank classification. Data were summarized in a meta-analysis using fixed and random effects inverse-generic meta-analyses. Results: A total of 7,034 records involving 89 studies that evaluated 1,352,097 individuals were included; 23 were high, 46 were moderate, and 20 were of low quality. A total of 123 risk factors were found. Meta-analysis revealed that the strongest risk factors found in the high-income countries were presence of dentinal caries (dmft greater than zero; odds ratio [OR] equals 4.21 [2.18 to 8.16]) and high levels of mutans streptococci (OR equals 3.83 [1.81 to 8.09]). In upper-middle-income countries, presence of enamel defects (OR equals 14.62 [6.10 to 35.03]) was found to be the strongest risk factor. Conclusion: The strongest risk factors associated with early childhood caries was the presence of enamel defects, presence of dentinal caries and high levels of mutans streptococci.


Assuntos
Cárie Dentária/etiologia , Índice CPO , Esmalte Dentário/anormalidades , Humanos , Fatores de Risco , Streptococcus mutans/isolamento & purificação
5.
Arch Oral Biol ; 101: 147-155, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30939297

RESUMO

OBJECTIVE: To document and describe the occurrence of an enamel pearl on the distal root surface of the maxillary M3 of the fossil hominin specimen from Florisbad, South Africa that is dated to ca. 259,000 years B.P., and is an early representative of Homo sapiens or as a member of the evolutionary line that was directly ancestral to modern humans. DESIGN: The molar was examined macroscopically and by micro-computed tomography (µCT) to enable accurate measurement and visualization of the structure of the enamel pearl. RESULTS: The single pearl has a diameter of 0.97 mm; it is a Type 2 "composite" pearl comprising an enamel cap and dentine core without pulp chamber involvement. The size of the Florisbad pearl falls within or just below the size ranges of this anomaly in modern human samples. Type 2 pearls are most commonly encountered in recent human populations, and the location of the pearl on the distal root surface of the Florisbad M3 is consistent with its most frequent location in recent humans. Pearls in recent human populations affect between 0.2-4.8% of individuals, and 1.7-6.8% of permanent molars. Pearls have been documented in several prehistoric human dentitions, and all examples are less than 4000 years old. CONCLUSIONS: Enamel pearls have been associated with periodontal disease, but it is not possible to relate its presence to the advanced periodontal inflammation and alveolar bone loss in the Florisbad fossil. Florisbad presents the earliest evidence of this anomaly in the fossil record pertaining to modern humans.


Assuntos
Esmalte Dentário/anormalidades , Fósseis , Hominidae , Animais , Esmalte Dentário/diagnóstico por imagem , Humanos , África do Sul , Microtomografia por Raio-X
6.
Methods Mol Biol ; 1922: 511-523, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30838597

RESUMO

Epidemiological investigations of early childhood oral health rely upon the collection of high-quality clinical measures of health and disease. However, ascertainment of valid and accurate clinical measures presents unique challenges among young, preschool-age children. The paper presents a clinical research protocol for the conduct of oral epidemiological examinations among children, implemented in ZOE 2.0, a large-scale population-based genetic epidemiologic study of early childhood caries (ECC). The protocol has been developed for the collection of information on tooth surface-level dental caries experience and tooth-level developmental defects of the enamel in the primary dentition. Dental caries experience is recorded using visual criteria modified from the International Caries Detection and Assessment System (ICDAS), and measurement of developmental defects is based upon the modified Clarkson and O'Mullane Developmental Defects of the Enamel Index. After a dental prophylaxis (toothbrushing among all children and flossing as needed), children's teeth are examined by trained and calibrated examiners in community locations, using portable dental equipment, compressed air, and uniform artificial light and magnification conditions. Data are entered directly onto a computer using a custom Microsoft Access-based data entry application. The ZOE 2.0 clinical protocol has been implemented successfully for the conduct of over 6000 research examinations to date, contributing phenotype data to downstream genomics and other "omics" studies of ECC and DDE, as well as traditional clinical and epidemiologic dental research.


Assuntos
Cárie Dentária/patologia , Esmalte Dentário/patologia , Saúde Bucal , Dente Decíduo/patologia , Pré-Escolar , Cárie Dentária/diagnóstico , Esmalte Dentário/anormalidades , Esmalte Dentário/crescimento & desenvolvimento , Pesquisa em Odontologia/métodos , Humanos , Manejo de Espécimes/métodos , Dente Decíduo/anormalidades , Dente Decíduo/crescimento & desenvolvimento
7.
Compend Contin Educ Dent ; 40(3): 172-177, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30829499

RESUMO

This case report describes the management of a mandibular first molar with an additional distolingual root (radix entomolaris) and grade III cervical enamel projection through a multidisciplinary approach. Diagnosis for the case was endodontic-periodontal lesion due to non-vitality and associated advanced periodontal destruction. The patient was treated with drainage of the periodontal abscess with adjunct antibiotics, phase I periodontal therapy, endodontic therapy, radiculoplasty, regenerative periodontal therapy, replacement of the missing right mandibular second molar, and long-term maintenance. Follow-up of the patient up to 9 months has been uneventful. Cases of advanced periodontal destruction typically show some degree of tooth mobility, which was absent in this case. The article discusses the tripod effect as well as the increased surface area for periodontal attachment provided by the additional root contributing to the non-mobility of the involved tooth.


Assuntos
Esmalte Dentário/anormalidades , Dente Molar/anormalidades , Abscesso Periodontal/terapia , Anormalidades Dentárias/terapia , Grupo com Ancestrais do Continente Asiático , Humanos , Masculino , Mandíbula , Pessoa de Meia-Idade , Dente Molar/diagnóstico por imagem , Abscesso Periodontal/diagnóstico por imagem , Abscesso Periodontal/etiologia , Radiografia Dentária , Anormalidades Dentárias/complicações , Anormalidades Dentárias/etnologia
8.
Indian J Pathol Microbiol ; 62(1): 95-98, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30706867

RESUMO

Glomerulocystic kidney disease (GCKD) is an uncommon type of cystic renal disease affecting children. It has both sporadic and familial occurrence and is characterized by cortical microcysts associated with dilatation of Bowman's spaces. In some instances, GCKD is an early manifestation of autosomal dominant polycystic kidney disease. Here, we present three cases of GCKD, two in infants and one in a perinatal postmortem. The first one is a case of GCKD with unilateral involvement, diagnosed on surgical biopsy. GCKD is a morphological expression of several hereditary and nonhereditary disorders that differ vastly in their management and long-term outcome. Hence, accurate morphological diagnosis of this entity is important for prognostication and genetic counseling.


Assuntos
Doenças do Sistema Nervoso Central/diagnóstico , Esmalte Dentário/anormalidades , Diabetes Mellitus Tipo 2/diagnóstico , Doenças Renais Císticas/diagnóstico , Rim Policístico Autossômico Dominante/diagnóstico , Biópsia , Doenças do Sistema Nervoso Central/patologia , Esmalte Dentário/patologia , Diabetes Mellitus Tipo 2/patologia , Feminino , Humanos , Lactente , Recém-Nascido de muito Baixo Peso , Rim/diagnóstico por imagem , Rim/patologia , Doenças Renais Císticas/patologia , Doenças Renais Císticas/cirurgia , Masculino , Nefrectomia , Rim Policístico Autossômico Dominante/patologia , Rim Policístico Autossômico Dominante/cirurgia , Ultrassonografia
9.
J Diabetes Investig ; 10(4): 1112-1115, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30637974

RESUMO

Here, we report phenotypic differences and similarities of monozygotic twins with maturity-onset diabetes of the young type 5 harboring a partial deletion of chromosome 17q12. The proband and her twin sister manifested complete aplasia and marked hypoplasia, respectively, of the body and tail of the pancreas. Whereas both twins showed marked hypoplasia of the right kidney and multiple cysts in both kidneys, only the proband's sister showed hydronephrosis in the left kidney. The proband had profound defects in insulin and glucagon secretion, as well as mild renal dysfunction, whereas her sister had pronounced renal dysfunction accompanied by mild defects in insulin and glucagon secretion. Both twins manifested hypomagnesemia and hyperuricemia, but no apparent liver dysfunction or intellectual disability. The severity of renal and pancreatic defects differed between monozygotic twins with maturity-onset diabetes of the young type 5, suggesting that the phenotypes of this condition are determined not solely by genetic factors.


Assuntos
Biomarcadores/análise , Doenças do Sistema Nervoso Central/fisiopatologia , Esmalte Dentário/anormalidades , Diabetes Mellitus Tipo 2/fisiopatologia , Fator 1-beta Nuclear de Hepatócito/genética , Doenças Renais Císticas/fisiopatologia , Nefropatias/diagnóstico , Pancreatopatias/diagnóstico , Adulto , Esmalte Dentário/fisiopatologia , Feminino , Deleção de Genes , Humanos , Incidência , Secreção de Insulina , Nefropatias/epidemiologia , Pancreatopatias/epidemiologia , Fenótipo , Gêmeos Monozigóticos
10.
Int J Paediatr Dent ; 29(1): 29-35, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30341791

RESUMO

BACKGROUND: Oestrogen (ES) and growth hormone (GH) are hormones that may have a role in caries aetiology and developmental defects of enamel (DDE) since their receptors (ERs and GHR) are expressed during amelogenesis. AIM: To evaluate whether genetic polymorphisms in the genes that codify the ERα (ESR1) and GHR are associated with caries experience and DDE in children. DESIGN: Two hundred and sixteen children of both genders, aged 9-12 years, were examined and classified according to caries and DDE phenotype. Genomic DNA was extracted from buccal cells in saliva. Genetic polymorphisms in ERS1 (rs1884051 and rs12154178) and GHR (rs297305, rs2940913, rs2910875, and rs1509460) were genotyped using TaqMan chemistry. Data were analysed by PLINK, while the chi-square test was used to compare allele and genotype distributions (alpha of 5%). RESULTS: A total of 131 children (60.7%) had caries experience, and 43 (19.9%) presented DDE. Genotype and allele distributions were not associated with caries experience (P > 0.05). Genotype and allele distributions between DDE, affected and unaffected, were associated with the polymorphism rs12154178 in ESR1 (P = 0.01 and P = 0.001, respectively) and with the polymorphism rs1509460 in GHR (P = 0.05 and P = 0.02, respectively). CONCLUSIONS: Genetic polymorphisms in ERS1 (rs12154178) and GHR (rs1509460) are associated with DDE.


Assuntos
Cárie Dentária/genética , Esmalte Dentário/anormalidades , Receptor alfa de Estrogênio/genética , Polimorfismo Genético , Receptores da Somatotropina/genética , Criança , Feminino , Genótipo , Humanos , Masculino
11.
Oral Dis ; 25(2): 543-549, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30537164

RESUMO

OBJECTIVE: Developmental defects of enamel (DDE) in preterm infants still require clarification and may favour dental caries, lower food intake and greater difficulty with weight-height gain. We evaluated factors associated with DDE in preterm infants. SUBJECTS AND METHODS: In this prospective cohort study, we monitored 54 prematurely born infants from birth to 24 months of age. Trained and calibrated dentists examined the oral cavity of these children to identify and categorize DDE. Information on perinatal variables was collected from the infants' medical records and interviews with their mothers. The data were analysed using Student's t test, a chi-squared test and Pearson's product-moment correlation coefficient. RESULTS: A total of 46.3% of the 54 children presented DDE, which was observed more frequently in the left hemiarch in children born extremely (<28 weeks of gestation) or very preterm (28 to <32 weeks; RR = 2.2; 95% CI 1.3-3.6), with very low birthweight (<1,500 g; RR = 2.0; 95% CI 1.1-3.5), who were admitted to the neonatal intensive care unit (RR = 1.3; 95% CI 1.0-1.7), and who were intubated (RR = 1.6; 95% CI 1.1-2.2). CONCLUSIONS: The high incidence of incisor enamel defects, particularly on the left side, was related to higher risk prematurity and to local trauma from intubation.


Assuntos
Esmalte Dentário/anormalidades , Incisivo/anormalidades , Intubação Intratraqueal , Nascimento Prematuro/epidemiologia , Anormalidades Dentárias/epidemiologia , Dente Decíduo/anormalidades , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Recém-Nascido de muito Baixo Peso , Unidades de Terapia Intensiva Neonatal , Masculino , Admissão do Paciente , Estudos Prospectivos , Fatores de Risco
13.
Ann Clin Biochem ; 56(1): 90-94, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-29874928

RESUMO

BACKGROUND: Hypomagnesaemia is present in 40-50% of children with autosomal dominant renal cysts and diabetes syndrome (RCAD). On the contrary, the prevalence of hypomagnesaemia in children with autosomal dominant polycystic kidney disease (ADPKD) has never been examined. We aimed to investigate whether hypomagnesaemia is present in children with polycystic kidney diseases. METHODS: Children with cystic kidney diseases were investigated in a cross-sectional study. Serum concentrations of magnesium (S-Mg) and fractional excretion of magnesium (FE-Mg) were tested. Fifty-four children with ADPKD ( n = 26), autosomal recessive polycystic kidney disease (ARPKD) ( n = 16) and RCAD ( n = 12) with median age of 11.2 (0.6-18.6) years were investigated. RESULTS: Hypomagnesaemia (S-Mg < 0.7 mmol/L) was detected in none of the children with ADPKD/ARPKD and in eight children (67%) with RCAD. Median S-Mg in children with ADPKD/ARPKD was significantly higher than in children with RCAD (0.89 vs. 0.65 mmol/L, P < 0.01). The FE-Mg was increased in 23% of patients with ADPKD/ARPKD (all had chronic kidney disease stages 2-4) and in 63% of patients with RCAD, where it significantly correlated with estimated glomerular filtration rate (r = -0.87, P < 0.01). CONCLUSIONS: Hypomagnesaemia is absent in children with ADPKD or ARPKD and could serve as a marker for differential diagnostics between ADPKD, ARPKD and RCAD in children with cystic kidney diseases of unknown origin where molecular genetic testing is lacking. However, while hypomagnesaemia, in the absence of diuretics, appears to rule out ADPKD and ARPKD, normomagnesaemia does not rule out RCAD at least in those aged <3 years.


Assuntos
Hipercalciúria/epidemiologia , Magnésio/sangue , Nefrocalcinose/epidemiologia , Rim Policístico Autossômico Dominante/epidemiologia , Erros Inatos do Transporte Tubular Renal/epidemiologia , Adolescente , Doenças do Sistema Nervoso Central/sangue , Doenças do Sistema Nervoso Central/diagnóstico , Doenças do Sistema Nervoso Central/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Esmalte Dentário/anormalidades , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Diagnóstico Diferencial , Feminino , Humanos , Hipercalciúria/sangue , Hipercalciúria/diagnóstico , Lactente , Recém-Nascido , Doenças Renais Císticas/sangue , Doenças Renais Císticas/diagnóstico , Doenças Renais Císticas/epidemiologia , Masculino , Nefrocalcinose/sangue , Nefrocalcinose/diagnóstico , Rim Policístico Autossômico Dominante/sangue , Rim Policístico Autossômico Dominante/diagnóstico , Rim Policístico Autossômico Recessivo/sangue , Rim Policístico Autossômico Recessivo/diagnóstico , Rim Policístico Autossômico Recessivo/epidemiologia , Prevalência , Erros Inatos do Transporte Tubular Renal/sangue , Erros Inatos do Transporte Tubular Renal/diagnóstico
14.
Oral Dis ; 25(6): 1446-1464, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30338628

RESUMO

OBJECTIVE: To evaluate studies assessing the prevalence of dental caries and developmental defects of enamel (DDE) in individuals with chronic kidney disease (CKD) in comparison with individuals without CKD. MATERIALS AND METHODS: Electronic searches were performed in PubMed, Web of Science, Scopus, Medline via Ovid, and ProQuest databases from their inception date until February 2018. Two review authors independently selected the studies, extracted data, and assessed the methodological quality. Meta-analysis was performed. RESULTS: Twenty-seven studies were included in this study. For permanent teeth, 14 studies found that individuals without CKD had higher dental caries scores than those with CKD. However, only five studies presented results with a statistically significant difference between groups. Among the studies evaluating primary teeth, five showed that individuals without CKD had higher dental caries scores than those with CKD. Five studies showed that individuals with CKD had a significantly higher prevalence of DDE than individuals without CKD. The meta-analyses showed that individuals without CKD had significantly higher scores of dental caries teeth and surfaces than individuals with CKD. For DDE, no statistical difference between groups was observed. CONCLUSIONS: Individuals with CKD present lower dental caries scores and a higher prevalence of DDE in comparison with individuals without CKD.


Assuntos
Cárie Dentária/epidemiologia , Esmalte Dentário/anormalidades , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/epidemiologia , Anormalidades Dentárias/epidemiologia , Estudos de Casos e Controles , Cárie Dentária/etiologia , Humanos , Prevalência , Anormalidades Dentárias/complicações , Dente Decíduo
15.
Acta odontol. latinoam ; 32(1): 44-49, 2019. ilus, tab
Artigo em Inglês | LILACS | ID: biblio-1015144

RESUMO

Clinically, MolarIncisor Hypomineralization (MIH) lesions are not distributed symmetrically, and their severity varies even within the same arcade. Aim: To estimate the frequency of asymmetries in hypomineralized lesions on permanent molars and incisors of children with MIH. Methods: Three pediatric dentists, calibrated following the diagnostic criteria of MathuMuju and Wright (2006) (Kappa 0.87) identified presence and severity of opacities on molars and incisors of patients with MIH. Six pairs of teeth (permanent maxillary and mandibular first molars, central and lateral incisors) were evaluated in each patient. Degree of lesion severity (0­none, 1­mild, 2­moderate, 3­severe) was recorded for each tooth. For each pair containing any affected teeth, asymmetry of presence (one tooth in the pair with lesion and the other intact), asymmetry of severity (both teeth with lesions but with different degrees of severity) or symmetry of severity (both affected teeth with the same degree of severity) were evaluated. The recorded values were entered into a database to calculate percentages, 95% confidence intervals and ChiSquare test for comparisons. Results: The sample consisted of 475 of the 1032 pairs of teeth evaluated in the 172 patients included in the study, mean age 11± 2.2 years, and 50% female. Asymmetry was found for 67.5% (63.1 71.7) of the pairs of the studied teeth. There was a significant relationship between asymmetries and symmetries (p=0.038). A total 50.1% of the pairs were asymmetrical for presence of opacities. Of these, 62.2% scored severity 1 (mild). Symmetry of severity was found for 32.5% of the lesions. Among the pairs of affected teeth, the most frequently observed degrees of lesion severity were mild and moderate, with the exception of lower molars, in which 49% had severe lesions. Conclusions: In this study, MIH lesions were asymmetrical both in presence and severity for all tooth types (AU)


Clínicamente las lesiones de Hipomineralización Molar Incisiva (HMI) no tienen una distribución simétrica variando su severidad inclusive en la misma arcada. Objetivo: Estimar la frecuencia de asimetrías en lesiones de hipomineralización en molares e incisivos permanentes de niños afectados con HMI. Métodos: Tres odontopediatras calibrados (Kappa 0,87) según los criterios de diagnóstico de MathuMuju y Wright (2006), registraron presencia y severidad de opacidades en molares e incisivos de pacientes con HMI. En cada paciente se evaluaron 6 pares de piezas dentarias permanentes: primeros molares, incisivos centrales y laterales de ambos maxilares. Para cada una de las piezas se registró el grado de severidad de la lesión (0­intacto, 1­leve, 2­moderado, 3­severo). Para cada par con alguna de sus piezas afectadas, se analizó si presentaba asimetría de presencia (una pieza del par con lesión y la otra intacta), asimetría de severidad (ambas piezas con lesión pero con distinto grado de severidad) o simetría (ambas piezas afectadas con el mismo grado de severidad en la lesión). Se calcularon porcentajes, I.C. del 95% y CHI2 para las comparaciones. Resultados: La muestra quedó conformada por los 475 pares de piezas dentarias que presentaron lesión entre un total de 1032 pares de piezas analizadas en los 172 pacientes incluidos en el estudio (edad media 11 ± 2,2 años, 50% género femenino). El 67,5% (63,171,7) de los pares de piezas dentarias estudiados presentaron relación de asimetría. La relación entre frecuencia de asimetrías y simetrías fue significativa (p= 0,038). Del 50,1% de los pares que presentó asimetrías en presencia, un 62,2% mostró grado de severidad 1(leve) en una de sus piezas. Entre los pares afectados, las lesiones leves y moderadas fueron las más observadas en todos los grupos dentarios, a excepción de los molares inferiores que revelaron un 49% de lesiones severas. Conclusiones: En este estudio las lesiones de HMI presentaron, en su mayoría, algún tipo de asimetría (de presencia o de severidad) en todos los grupos dentarios (AU)


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Anormalidades Dentárias , Desmineralização do Dente , Esmalte Dentário/anormalidades , Incisivo , Dente Molar , Argentina , Estudos Transversais , Análise Estatística , Estudos Prospectivos , Assistência Odontológica para Crianças , Dentição Permanente , Estudo Observacional
16.
Braz Oral Res ; 32: e87, 2018 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-30110085

RESUMO

Sickle cell anemia, a genetic disease caused by a mutation in the beta-globin gene, can present oral manifestations such as delayed tooth eruption and hypomineralized enamel and dentin. The aim of the present study was to evaluate the prevalence and severity of developmental defects of enamel (DDE) and delayed tooth eruption in children with sickle cell anemia. The sample comprised 56 male and female children with sickle cell anemia aged 6 to 12 years and treated at the Hematology and Hemotherapy Center of Pernambuco, Brazil. The data were collected according to the WHO criteria for DDE and tooth eruption. The prevalence of DDE was 58.2% and increased with age, affecting 43.8% of children aged 6 to 8 years and 66.7% of those aged 10 to 12 years (p>0.05; Pearson's chi-square test). There was no significant association between DDE and sex; the most prevalent type of DDE was diffuse opacity (6.2%). Tooth eruption was delayed in 18 children (32.1%). The delay increased with age and was detected in 11.8% of children aged 6 to 8 years, in 20.0% of those aged 8 to 10 years and in 54.2% of those aged 10 to 12 years (p<0.05; Pearson's chi-square test). Delayed tooth eruption was higher in males (36.7%, p>0.05). The prevalence of DDE was high, increased with age and was similar between sexes, while delayed eruption was higher in males and showed a significant association with age.


Assuntos
Anemia Falciforme/epidemiologia , Esmalte Dentário/anormalidades , Odontopatias/epidemiologia , Erupção Dentária , Distribuição por Idade , Fatores Etários , Anemia Falciforme/complicações , Brasil/epidemiologia , Criança , Estudos Transversais , Hipoplasia do Esmalte Dentário/epidemiologia , Hipoplasia do Esmalte Dentário/etiologia , Feminino , Humanos , Masculino , Prevalência , Índice de Gravidade de Doença , Distribuição por Sexo , Fatores Sexuais , Odontopatias/etiologia
17.
Adv Clin Exp Med ; 27(11): 1535-1540, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30066500

RESUMO

BACKGROUND: Both positive and negative associations between developmental enamel defects (DED) and dental caries have been reported in the literature. OBJECTIVES: The aim of this study was to assess the prevalence of DED of permanent dentition and its association with dental caries in schoolchildren living in Poznan (Wielkopolskie Voivodeship, Poland). MATERIAL AND METHODS: A total of 2,522 6th grade children and 3,112 1st grade children were examined. Developmental enamel defects were described using the modified Developmental Defects of Enamel Index. Dental caries experience was assessed in accordance with the number of decayed, missing and filled teeth (DMFT). RESULTS: The study revealed 475 children (9.6%) to have at least 1 enamel defect of permanent dentition. In 6th-graders, statistical analysis confirmed significant differences between DMFT, DT (decayed teeth) and FT (filled teeth) numbers of various DED groups with subjects affected by diffuse opacities having generally the lowest caries indices and subjects with enamel hypoplasia and/or demarcated opacities having the highest caries indices. In both age groups, dental caries prevalence was statistically significantly higher in subjects with hypoplasia and/or demarcated opacities as compared to subjects without DED or with diffuse opacities (p < 0.05). CONCLUSIONS: The prevalence of DED in the examined population was low and comparable to those reported in regions without fluoridated water. The study confirmed that children affected by diffuse enamel opacities were less susceptible to dental caries, while demarcated opacities and hypoplasia should be considered important dental caries risk factors.


Assuntos
Cárie Dentária/complicações , Cárie Dentária/epidemiologia , Hipoplasia do Esmalte Dentário/complicações , Hipoplasia do Esmalte Dentário/epidemiologia , Esmalte Dentário/anormalidades , Criança , Índice CPO , Feminino , Humanos , Masculino , Polônia/epidemiologia , Prevalência , Dente Decíduo
18.
Indian J Dent Res ; 29(4): 517-520, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30127205

RESUMO

Little research has been performed on tomographic observations of the dental development anomaly known as enamel pearl. This article presents a clinical case report in which enamel pearl was detected through cone beam computed tomography (CBCT). In this study, a patient was referred to undergo a CBCT of the left maxillary molar region, due to the patient's pain symptoms in this region. The CBCT showed the existence of an enamel pearl in tooth 27. A precise diagnosis made it possible for the patient to begin the preventive treatment against periodontal disease in tooth 27.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Esmalte Dentário/anormalidades , Esmalte Dentário/diagnóstico por imagem , Adulto , Feminino , Humanos , Maxila/diagnóstico por imagem , Dente Molar/diagnóstico por imagem , Doenças Periodontais/etiologia , Doenças Periodontais/cirurgia , Extração Dentária
19.
J Clin Endocrinol Metab ; 103(10): 3601-3610, 2018 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-30032214

RESUMO

Context: Maturity-onset diabetes of the young type 5 (MODY5) is caused by mutations of the hepatocyte nuclear factor 1 homeobox ß gene (HNF1B). Although clinical characteristics and therapeutic management of MODY5 are increasingly better defined, adequate consideration of the frequent association of MODY5 with 17q12 deletion syndrome is often missing. Evidence Acquisition: We report two cases of patients with 17q12 deletion syndrome who presented to our clinic. Furthermore, we reviewed the existing literature to improve systematic diagnostic and therapeutic approaches. A PubMed search using the terms 17q12 deletion syndrome, diabetes mellitus type MODY5, and/or HNF1B was performed. Evidence Synthesis: Three hundred sixty-one cases of postnatal 17q12 deletion syndrome were assessed, and details on clinical manifestations, diagnostic approaches, and therapeutic management were reviewed and compared with the two cases at our clinic. Furthermore, data on pathogenic mechanisms and their clinical implications were evaluated. Conclusion: The 17q12 deletion syndrome usually comprises MODY5, structural or functional abnormalities of the kidneys, and neurodevelopmental or neuropsychiatric disorders. A complete deletion of HNF1B can be found in about 50% of patients with MODY5. A wide variety of additional clinical features, including genital and brain malformations, has been reported. Because HNF1B deletions are virtually always part of a 17q12 deletion syndrome and common genetic analyses for evaluation of MODY5 are unable to detect the deletion of a 1.4-Mb chromosomal region, initial attention to the syndromal features at the stage of diagnosis is of considerable importance for establishing correct diagnosis, subsequent therapy, and interdisciplinary patient care.


Assuntos
Doenças do Sistema Nervoso Central/etiologia , Deleção Cromossômica , Cromossomos Humanos Par 17/genética , Esmalte Dentário/anormalidades , Diabetes Mellitus Tipo 2/etiologia , Fator 1-beta Nuclear de Hepatócito/genética , Doenças Renais Císticas/etiologia , Adolescente , Adulto , Doenças do Sistema Nervoso Central/genética , Doenças do Sistema Nervoso Central/patologia , Esmalte Dentário/patologia , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/patologia , Feminino , Humanos , Doenças Renais Císticas/genética , Doenças Renais Císticas/patologia , Síndrome
20.
Rev. cuba. estomatol ; 55(2): 1-10, abr.-jun. 2018. ilus
Artigo em Espanhol | CUMED | ID: cum-72242

RESUMO

Introducción: la amelogénesis imperfecta consiste en un grupo de desórdenes hereditarios que afectan el desarrollo del esmalte dental, de tal forma que se ve comprometida la apariencia clínica de todos o casi todos los dientes, tanto temporales como permanentes. Objetivo: informar las características y condiciones clínicas de la dentición de tres individuos de una misma familia con diagnóstico presuntivo de amelogénesis imperfecta. Presentación de casos: se realizó examen intrabucal a tres individuos con rango de consanguinidad de primer grado (madre y dos hijos) quienes presentaban alterado estructuralmente el esmalte de los dientes. De acuerdo con las características clínicas dentales y el método de Witkop, los individuos fueron diagnosticados de forma presuntiva con amelogénesis imperfecta hipomadura tipo II (madre), caracterizada por hipomaduración del esmalte y fragmentación por desgaste en los bordes incisales; amelogénesis imperfecta hipoplásica tipo I (hijo mayor), con amplias zonas de dentina expuesta opaca y con manchas pardas generalizadas; y amelogénesis imperfecta hipomadura tipo II (hijo menor), con predominio de lesiones en forma de copo de nieve o motas de algodón. Conclusiones: el diagnóstico clínico de la amelogénesis imperfecta basado en métodos fenotípicos resulta impreciso debido a la imposibilidad de establecer el origen de las alteraciones macroestructurales del esmalte. Sin embargo, de acuerdo con la descripción de los tres casos, son las afecciones en la cantidad y calidad del esmalte las que permiten realizar un diagnóstico clínico presuntivo, que guía la implementación de un tratamiento odontológico direccionado a la solución del compromiso estético y a la prevención del compromiso del órgano dentino-pulpar. En esta presentación de casos, la manifestación fenotípica de la enfermedad pasó de la madre a ambos hijos, siendo la amelogénesis imperfecta hipomadura dominante en el hijo menor(AU)


Introduction: amelogenesis imperfecta consists of a group of hereditary disorders that affect the development of the dental enamel in such a way that the clinical appearance of all or almost all primary and permanent teeth is compromised. Objective: report the clinical characteristics and conditions of the dentition of three individuals from the same family with a presumptive diagnosis of amelogenesis imperfecta. Case presentation: intraoral examination was performed of three first-degree relatives (mother and two children) with structurally altered tooth enamel. Based on their clinical dental characteristics and the results of the Witkop method, the individuals were presumptively diagnosed with hypomaturation amelogenesis imperfecta type II (mother), characterized by enamel hypomaturation and fragmentation by wear on the incisal edges; hypoplastic amelogenesis imperfecta type I (elder son), with large areas of opaque exposed dentin and generalized brown spots; and hypomaturation amelogenesis imperfecta type II (younger son), with a predominance of lesions in the shape of snowflakes or cotton wads. Conclusions: clinical diagnosis of amelogenesis imperfecta based on phenotypic methods is imprecise, since it is not possible to establish the origin of the macrostructural alterations of the enamel. However, according to the description of the three cases, quantitative and qualitative damage to the enamel makes it possible to establish a presumptive clinical diagnosis which will guide the implementation of a dental treatment aimed at resolving the aesthetic commitment and preventing involvement of the dentine-pulp complex. In this case presentation, the phenotypic manifestation of the disease passed from the mother to both children, and hypomaturation amelogenesis imperfecta was dominant in the younger son(AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Fatores de Risco , Esmalte Dentário/anormalidades , Amelogênese Imperfeita/diagnóstico , Amelogênese Imperfeita/terapia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA