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1.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 33(4): 380-386, 2021 Aug 24.
Artigo em Chinês | MEDLINE | ID: mdl-34505445

RESUMO

OBJECTIVE: To construct a cDNA library of Sparganum mansoni and immunoscreen antigen candidates for immunodiagnosis of sparganosis mansoni. METHODS: Total RNA was extracted from S. mansoni, and reversely transcribed into cDNA, which was ligated into the phage vector. These recombinant vectors were packaged in vitro to construct the SMART cDNA library of S. mansoni. Then, the cDNA library was immunoscreened with sera from patients with sparganosis mansoni to yield positive clones. The inserted fragments of positive clones were sequenced and subjected to homology analyses, and the structure and functions of the coding proteins were predicted. RESULTS: The SMATR cDNA library of S. mansoni was successfully constructed. The titer of the cDNA library was 6.25 × 106 pfu/mL, with a recombinant efficiency of 100%, and the mean length of the inserted fragments in the library was larger than 1 100 bp. A total of 12 positive clones were obtained by immunoscreening, and were categorized into Sm-I (Sm60-1), Sm-II (Sm58-1), Sm-III (Sm20-1) and Sm-IV (Sm22-3), with 1 134, 1 063, 883 bp and 969 bp long inserted fragments. Their coding proteins were highly homologous with the Spirometra erinaceieuropaei antigenic polypeptide, cytoplasmic antigen, ribosomal protein S4-like protein and unnamed protein product, respectively. CONCLUSIONS: A SMART cDNA library of S. mansoni has been successfully constructed and 4 categories of positive clones have been identified, which provides a basis for further studies on diagnostic antigens for sparganosis mansoni.


Assuntos
Esparganose , Plerocercoide , Animais , Sequência de Bases , DNA Complementar/genética , Biblioteca Gênica , Humanos
2.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 33(4): 439-441, 2021 Jan 19.
Artigo em Chinês | MEDLINE | ID: mdl-34505457

RESUMO

This case report presents the diagnosis and treatment of a case with subcutaneous sparganosis.


Assuntos
Esparganose , Humanos , Esparganose/diagnóstico , Esparganose/cirurgia
3.
Korean J Parasitol ; 59(2): 153-157, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33951771

RESUMO

This study reports the first two clinical cases of spirometrosis caused by Spirometra sp. in cats in Korea. In these two cases, the cats vomited, and long proglottids of tapeworm were recovered. The sick cats presented with anorexia and lethargy. However, they unexpectedly showed no diarrhea, which is the main symptom of spirometrosis. Based on a fecal floatation test as well as morphological and molecular analyses, the parasite was diagnosed as Spirometra sp. The 2 cases were treated with praziquantel. This study suggests regular monitoring of health and deworming in companion animals, even when animals are well cared for, with regular preventive medication. Additionally, spirometrosis should be considered in the differential diagnosis in cases of gastrointestinal symptoms in Spirometra endemic areas.


Assuntos
Doenças do Gato/parasitologia , Esparganose/veterinária , Spirometra/isolamento & purificação , Animais , Anti-Helmínticos/administração & dosagem , Doenças do Gato/tratamento farmacológico , Gatos , Praziquantel/uso terapêutico , República da Coreia , Esparganose/tratamento farmacológico , Esparganose/parasitologia , Spirometra/classificação , Spirometra/efeitos dos fármacos , Spirometra/genética
4.
Clin Infect Dis ; 72(5): 882-890, 2021 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-32702118

RESUMO

Sparganosis is a relatively neglected foodborne and waterborne disease caused by species of the tapeworm genus Spirometra, the global distribution of which has not been sufficiently recognized. Known mainly as a zoonosis of East Asia, its species are native to all inhabited continents including Europe. Spirometra has been reported from numerous wildlife species from 17 European countries, and a critical review confirmed 17 autochthonous and 8 imported human clinical cases. We present the first molecular evidence of the coincident presence of 2 species in Europe and review the current distribution to raise awareness of the parasite in this region. Spirometra erinaceieuropaei is restricted to Europe and Spirometra mansoni represents a lineage distributed mainly across Asia and Oceania that reaches Europe. The parasite is common in Eastern Europe and its distribution has potential to expand along with its invasive or migrating mammal hosts, spreading the risks of human infection.


Assuntos
Esparganose , Spirometra , Animais , Ásia/epidemiologia , Europa (Continente)/epidemiologia , Humanos , Esparganose/diagnóstico , Esparganose/epidemiologia , Spirometra/genética , Zoonoses/epidemiologia
5.
Intern Med ; 60(4): 601-604, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-32999230

RESUMO

A 77-year-old woman presented at our hospital to undergo a close examination of an abnormal shadow which was observed on a chest radiograph. Contrast-enhanced computed tomography (CT) images in the lung window revealed a tortuous tunnel structure (tunnel sign), which was suspected to be the migration path of a parasite. Furthermore, CT images in the mediastinal window showed a linear filling defect from the right inferior pulmonary vein to the venous ostium in the left atrium (migrating sign), which was suspected to be a migrating parasite in the pulmonary vein. Tunnel and migrating signs on chest CT images were helpful in diagnosing pulmonary sparganosis.


Assuntos
Veias Pulmonares , Esparganose , Idoso , Feminino , Átrios do Coração/diagnóstico por imagem , Humanos , Pulmão/diagnóstico por imagem , Veias Pulmonares/diagnóstico por imagem , Esparganose/diagnóstico por imagem , Tomografia Computadorizada por Raios X
6.
Am J Trop Med Hyg ; 104(1): 298-302, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33124542

RESUMO

Spinal sparganosis of the cauda equina has been rarely reported. A 54-year-old man presented at the hospital after having experienced lower back pain for 10 months, progressive weakness and numbness of the left leg for 4 months, and urinary incontinence for 3 weeks. Magnetic resonance imaging of the lumbosacral spine revealed a heterogeneous enhancing mass at the T12-S1 level. Spinal sparganosis was diagnosed by histological examination and molecular identification of the parasite in the tissue section. The patient was treated with a high dose of praziquantel because the parasitic mass was only partially removed and symptoms worsened following surgery.


Assuntos
Cauda Equina/parasitologia , Esparganose/diagnóstico , Anti-Helmínticos/administração & dosagem , Anti-Helmínticos/uso terapêutico , Antiulcerosos/administração & dosagem , Antiulcerosos/uso terapêutico , Cauda Equina/diagnóstico por imagem , Cauda Equina/patologia , Cimetidina/administração & dosagem , Cimetidina/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Polirradiculopatia/etiologia , Praziquantel/administração & dosagem , Praziquantel/uso terapêutico , Esparganose/patologia , Esparganose/cirurgia
7.
Parasitol Res ; 120(1): 365-371, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33174072

RESUMO

Diphyllobothriid tapeworms of the genus Spirometra are causative agents of sparganosis, food-borne zoonotic parasitic disease. They have been recorded in broad spectrum of hosts, including humans, in all continents except Antarctica. Spirometra tapeworms have been intensively studied in several Asian countries; however, they have been rather neglected in Europe. The aim of this study was to provide a pilot screening of Spirometra spp. in Latvia, where data on sparganosis are not available. Tapeworms morphologically identified as diphyllobothriid species were isolated from grey wolves Canis lupus and Eurasian lynxes Lynx lynx from Latvia during the hunting periods 2013-2019. The parasites were subjected to molecular genotyping using sequences of the partial large (LSU rDNA; 615 bp) and small (SSU rDNA; 720 bp) subunits of the nuclear ribosomal RNA gene and complete (1566 bp) cytochrome c oxidase subunit I gene of the mitochondrial DNA (cox1 mtDNA). Analyses of both ribosomal subunits of 13 tapeworms revealed no intraspecific variation within the respective rDNA subunits. On the other hand, sequence analysis of mitochondrial cox1 revealed intraspecific polymorphism displayed by 12 cox1 haplotypes. Comparison of the current data with sequences of the corresponding DNA regions deposited in the GenBank revealed 99.3-99.5% (LSU rDNA), 99.2% (SSU rDNA) and 99.6-100% (cox1 mtDNA) identity of studied tapeworms with Spirometra erinaceieuropaei, which provided the first confirmation of this diphyllobothriid tapeworm in Latvia. Since S. erinaceieuropaei is probably prevalent in Latvian wildlife and may also occur in other potential host species, further studies are needed in order to acquire complex data on its geographic distribution and transmission in the natural environment of Latvia, as well as on the spectrum of its intermediate, paratenic, and definitive hosts.


Assuntos
Lynx/parasitologia , Esparganose/epidemiologia , Esparganose/veterinária , Spirometra/isolamento & purificação , Lobos/parasitologia , Animais , Animais Selvagens/parasitologia , Ciclo-Oxigenase 1/genética , DNA Mitocondrial/genética , DNA Ribossômico/genética , Feminino , Humanos , Letônia/epidemiologia , Masculino , Tipagem Molecular , Filogenia , Esparganose/transmissão , Spirometra/genética , Zoonoses/parasitologia , Zoonoses/transmissão
8.
Korean J Parasitol ; 58(5): 577-581, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33202511

RESUMO

A 22-year-old Thai man from the Northeast region presented with acute eye swelling, itching, and discharge on his left eye. He was suspected of having gnathostomiasis and treated with albendazole and prednisolone for 3 weeks. Nine months later, he was treated with high-dose oral prednisolone for the preliminary and differential diagnoses with thyroid-associated orbitopathy and lymphoma. He had been administered prednisolone intermittently over a few years. Then he developed a painless movable mass at the left upper eyelid and recurrent pseudotumor oculi was suspected. The surgical removal of the mass was performed. A white pseudosegmented worm revealed a definite diagnosis of ocular sparganosis by a plerocercoid larva. Molecular diagnosis of the causative species was made based on the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene. Proper technique of extraction and amplification of short fragments DNA from formalin-fixed paraffin-embedded tissue successfully identified parasite species. The result from the sequencing of the PCR-amplified cox1 fragments in this study showed 99.0% sequence homology to Spirometra ranarum. This is the first report of S. ranarum in Thailand.


Assuntos
Oftalmopatias/diagnóstico , Oftalmopatias/parasitologia , Olho/parasitologia , Esparganose/diagnóstico , Esparganose/parasitologia , Plerocercoide/genética , Plerocercoide/isolamento & purificação , Spirometra/genética , Spirometra/isolamento & purificação , Adulto , Animais , DNA de Helmintos , Diagnóstico Diferencial , Oftalmopatias/cirurgia , Genes de Helmintos/genética , Humanos , Masculino , Esparganose/cirurgia , Tailândia , Adulto Jovem
9.
Korean J Parasitol ; 58(3): 309-313, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32615744

RESUMO

Human sparganosis is a zoonotic disease caused by infection and migration of the plerocercoid of Spirometra spp. Although sparganosis were reported from most parts of the body, the sparganum parasitizing inside cerebral artery is remarkably uncommon. We report a case of cerebral intravascular sparganosis in an elderly patient with acute ischemic stroke who was diagnosed by retrieving sparganum during mechanical thrombectomy. Finally, the parasites were identified as Spirometra erinaceieuropaei using multiplex PCR and cox1 gene sequencing.


Assuntos
Artérias Cerebrais/parasitologia , Esparganose/parasitologia , Plerocercoide/isolamento & purificação , Spirometra/isolamento & purificação , Trombectomia/métodos , Idoso de 80 Anos ou mais , Animais , Grupo com Ancestrais do Continente Asiático , Humanos , Masculino , Esparganose/diagnóstico por imagem , Esparganose/transmissão , Plerocercoide/genética , Spirometra/genética , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/terapia
10.
Medicine (Baltimore) ; 99(22): e20226, 2020 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-32481388

RESUMO

RATIONALE: Sparganosis is an infectious disease caused by a larval tapeworm of the genus Spirometra, which commonly invades subcutaneous tissues. Pulmonary and pleural involvement due to sparganum has been rarely reported previously. PATIENT CONCERNS: We herein described a case of recurrent eosinophilic pleuritis in a 24-year-old woman. She was admitted with persistent cough and shortness of breath for more than 1 month. Initial chest computed tomography scan suggested right pleural effusion and diffuse pleural thickening. Slightly elevated eosinophil counts were found in both the peripheral blood and pleural fluid. She underwent right pleurectomy but histological examination failed to obtain an etiological diagnosis. Moreover, eosinophilic pleural effusion re-appeared in the contralateral thoracic cavity one month later. After re-admission, we reviewed her medical history meticulously and found she had a history of ingesting raw snake gallbladders before hospitalization. The final diagnosis was confirmed by the markedly positive reaction against sparganum antigen in both serum and pleural fluid sample. DIAGNOSIS: Eosinophilic pleuritis caused by sparganum infection. INTERVENTIONS: After the diagnosis, the patient was treated with praziquantel at 75 mg/kg/d for 3 days. OUTCOMES: Pleural effusion absorbed completely and eosinophil count in peripheral blood returned to normal range. No evidence of recurrent pleural effusion had been observed in over one year of follow-up. LESSONS: Clinicians need to be aware the possibility of sparganum infection in cases of eosinophilic pleuritis. The specific enzyme-linked immunosorbent assay remains a useful method in acquiring a rapid diagnosis, especially when histological examination is unable to detect the larvae in the thoracic cavity.


Assuntos
Eosinofilia/parasitologia , Pleurisia/parasitologia , Esparganose/diagnóstico , Anti-Helmínticos/uso terapêutico , Diagnóstico Diferencial , Ensaio de Imunoadsorção Enzimática , Eosinofilia/tratamento farmacológico , Feminino , Humanos , Medicina Tradicional Chinesa/efeitos adversos , Pleurisia/tratamento farmacológico , Praziquantel/uso terapêutico , Recidiva , Esparganose/tratamento farmacológico , Adulto Jovem
11.
J Helminthol ; 94: e131, 2020 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-32103785

RESUMO

Sparganosis is an important foodborne parasitic zoonosis; however, few reports on the prevalence of snake-infecting plerocercoids from Hunan province in China are available. Therefore, we investigated the prevalence of spargana infection in wild snakes from this region in 2018, and identified an astonishing prevalence rate of 91.7% (344/375). Spargana parasites were found in 99.1% of Zaocys dhumnades, 94.1% of Elaphe carinata and 86.7% of Elaphe taeniura. Parasites exhibited various distributions: 50% were located in muscular tissue, 32.1% in subcutaneous tissue and 17.9% in the coelomic cavity. To identify the specific status of spargana collected from wild snakes, partial mitochondrial cytochrome c oxidase subunit 1 (cox1) gene sequences were amplified, sequenced and analysed. Sequence variations for cox1 among all the examined plerocercoids ranged between 0.0 and 2.9%, with 21 variable sites identified (4.71%, 21/446). Phylogenetic analyses identified that all plerocercoids isolated from Hunan province were Spirometra erinaceieuropaei. This is the first report of S. erinaceieuropaei infection in snakes in Hunan province. The risks and harms of sparganosis should be publicized, and illegal wildlife trade should be controlled.


Assuntos
Serpentes/parasitologia , Esparganose/veterinária , Spirometra/genética , Animais , China/epidemiologia , DNA Mitocondrial/genética , Filogenia , Prevalência , Esparganose/epidemiologia , Spirometra/isolamento & purificação
12.
World Neurosurg ; 136: 341-347, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31996338

RESUMO

BACKGROUND: Spinal sparganosis associated with filum terminale arteriovenous fistula (FTAVF) has not been reported in the literature. In previous studies, these 2 rare diseases were usually reported separately. We report the first case of spinal sparganosis with concomitant FTAVF. CASE DESCRIPTION: Spinal sparganosis associated with FTAVF manifested in a middle-aged man with progressive back pain and paraparesis. Magnetic resonance imaging of the lumbosacral spine revealed large intradural mass-like lesions involving the conus medullaris and entire cauda equina. Additionally, there was degenerative spinal stenosis at the level of L2-3 to L5-S1. Magnetic resonance imaging of the thoracic spine disclosed abnormal hypersignal intensity extending from the level of the conus medullaris to T7 with tortuous intradural flow voids along the ventral more than dorsal surfaces of the spinal cord. Magnetic resonance angiography and spinal angiography confirmed FTAVF at the level of L3-4. The patient underwent surgical removal of the granulation tissues with lysis adhesions and obliteration of the FTAVF simultaneously in the same surgical session. Histologic findings were consistent with sparganosis. CONCLUSIONS: The formation of FTAVF in the present case may have resulted from severe spinal canal stenosis caused by lumbar spondylosis and spinal sparganosis, inducing chronic inflammation and severe adhesion of spinal nerve roots. This evidence indicates that FTAVF may have been acquired.


Assuntos
Fístula Arteriovenosa/complicações , Cauda Equina/diagnóstico por imagem , Esparganose/complicações , Doenças da Coluna Vertebral/complicações , Adulto , Fístula Arteriovenosa/diagnóstico por imagem , Fístula Arteriovenosa/cirurgia , Dor nas Costas/etiologia , Cauda Equina/cirurgia , Tecido de Granulação/patologia , Humanos , Angiografia por Ressonância Magnética , Imageamento por Ressonância Magnética , Masculino , Procedimentos Neurocirúrgicos/métodos , Paraparesia/etiologia , Esparganose/diagnóstico por imagem , Esparganose/cirurgia , Compressão da Medula Espinal/patologia , Doenças da Coluna Vertebral/diagnóstico por imagem , Doenças da Coluna Vertebral/cirurgia , Estenose Espinal/diagnóstico por imagem , Estenose Espinal/etiologia , Resultado do Tratamento
15.
Parasitol Int ; 75: 102036, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31841658

RESUMO

Proliferative sparganosis is one of the most bizarre and mysterious parasitic diseases ever described. The causative parasite is Sparganum proliferum, which is a pseudophyllidean cestode distinct from Spirometra tapeworms. Here we overview this rare but fascinating disease with the all original case reports on human patients published in the last 115 years. Proliferative sparganosis is clearly divided into two disease types, cutaneous and internal proliferative sparganosis. Cutaneous type starts with a skin eruption caused by the dermal invasion of a sparganum. Skin lesion progresses to larger areas of the body if left untreated. Various internal organs and body wall can be eventually affected. The clinical symptoms of patients in this group are very similar to each other. Molecular data suggest that cutaneous proliferative sparganosis is caused by S. proliferum of which genetic variation is limited, regardless of the time or localities of the emergence of patients. Internal proliferative sparganosis, on the other hand, is much more heterogeneous. Some cases show aggressive infection in internal organs, while others show only restricted lesions. Some of the cases that had been cited as proliferative sparganosis in the past literature were removed from the list, because they were judged as cyclophyllidean tapeworm infections. DNA sequencing is mandatory for the definite diagnosis of proliferative sparganosis. The Venezuelan strain of S. proliferum is maintained in experimental mice in Japan, which is fully prepared for the experimental study with advanced technologies in modern molecular biology.


Assuntos
Esparganose/parasitologia , Plerocercoide/fisiologia , Animais , Humanos , Dermatopatias Parasitárias/diagnóstico , Dermatopatias Parasitárias/parasitologia , Dermatopatias Parasitárias/patologia , Esparganose/classificação , Esparganose/diagnóstico , Esparganose/patologia
16.
Korean J Parasitol ; 57(5): 513-516, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31715692

RESUMO

Human sparganosis is a food-borne zoonosis mainly caused by the plerocercoid belonging to the genus Spirometra. The most common clinical sign of sparganosis is a subcutaneous mass in the trunk including abdominal or chest wall. The mass may be mistaken for a malignant tumor, thereby causing difficulty in terms of diagnosis and treatment. A 66-year-old woman visited our clinic for the removal of a lipoma-like mass. It was movable, hard, and painless. We identified 2 white mass, measuring 0.2×4 cm and 0.2×1 cm. Pathologic findings indicated the white mass was a sparganum. She recalled having eaten a raw frog approximately 60 years before. A 35-year-old who lived North Korea was also presented to our clinic with an asymptomatic nodule on her abdomen. Intraoperatively, we found sparganum approximately 24 cm size. Subcutaneous masses are associated with clinical signs of inflammation or they may mimic a soft tissue neoplasm. While the incidence rate of sparganosis has decreased with economic development and advancements in sanitation, surgeons still encounter patients with sparganosis in the clinical setting. Therefore, a careful history is required in order to diagnose sparganosis.


Assuntos
Abdome/cirurgia , Lipoma/parasitologia , Esparganose/parasitologia , Spirometra/isolamento & purificação , Adulto , Idoso , Animais , Feminino , Humanos , Lipoma/cirurgia , Esparganose/cirurgia , Spirometra/classificação , Spirometra/genética
17.
Am J Trop Med Hyg ; 101(5): 1170-1173, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31571569

RESUMO

Human sparganosis is a cestode infection which is neglected as a differential diagnosis outside endemic countries. Diagnosis and therapy may be challenging depending on the clinical presentation and anatomic localization. The disease manifests predominantly as subcutaneous nodule(s) or intracranial mass lesion(s). Infection is primarily acquired by ingesting raw or undercooked amphibian or reptile flesh or by drinking water containing copepods. We report an unusual case of subcutaneous Spirometra erinaceieuropaei sparganosis presenting with two nonmigratory nodules in close proximity to each other on the right thigh of a Thai woman living in Switzerland.


Assuntos
Emigrantes e Imigrantes , Esparganose/diagnóstico , Esparganose/patologia , Spirometra/isolamento & purificação , Tela Subcutânea/parasitologia , Animais , Sequência de Bases , DNA de Helmintos/genética , Feminino , Humanos , Pessoa de Meia-Idade , Esparganose/epidemiologia , Esparganose/cirurgia , Spirometra/genética , Suíça , Tailândia/epidemiologia
18.
BMC Infect Dis ; 19(1): 748, 2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31455261

RESUMO

BACKGROUND: Sparganosis, a rare and severe parasitic infection caused by the larvae of Spirometra species or simply sparganum, generally involves subcutaneous tissue or muscle. But occasionally, sparganum can also invade the human brain, resulting in cerebral sparganosis. CASE PRESENTATION: A 33-year-old woman presented with a 10-day history of headache. Postcontrast magnetic resonance imaging (MRI) revealed an irregular lesion with enhancement and the tunnel-shaped focus extending to the contralateral hemiphere. Cerebrospinal fluid (CSF) analysis disclosed pleocytosis (166 cells/µL) and an elevated protein concentration (0.742 g/L). Enzyme-linked immunosorbent assay (ELISA) revealed positive sparganum-specific antibody in both blood and CSF. Finally, the diagnosis of cerebral sparganosis was comfirmed. She received praziquantel treatment and got a favorable outcome during six-month follow-up. CONCLUSIONS: Irregular enhancement and the tunnel sign that extends to the contralateral hemisphere on postconstrast MRI are unusual presentations of cerebral sparganosis. ELISA for sparganum-specific antibody can help confirm the diagnosis. Although surgery is the preferred treatment for cerebral sparganosis, praziquantel might also achieve satisfying outcomes.


Assuntos
Encefalopatias/diagnóstico por imagem , Esparganose/diagnóstico por imagem , Adulto , Animais , Anti-Helmínticos/uso terapêutico , Anticorpos Anti-Helmínticos/sangue , Encefalopatias/parasitologia , Líquido Cefalorraquidiano/parasitologia , Meios de Contraste , Ensaio de Imunoadsorção Enzimática , Feminino , Cefaleia/parasitologia , Humanos , Imageamento por Ressonância Magnética/métodos , Praziquantel/uso terapêutico , Esparganose/tratamento farmacológico , Spirometra/imunologia , Spirometra/isolamento & purificação
19.
Am J Trop Med Hyg ; 101(5): 1174-1176, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31436160

RESUMO

A 50-year-old Chinese woman with a history of weakness and paroxysmal seizures of the left limb presented to our hospital with a ten-day history of neck pain. Imaging showed that there was a mass in the frontal lobe of her brain. On resection of the mass, a motile worm was identified. Morphological observation and molecular analysis of the mitochondrial COX1 and 28S rRNA genes of the worm extracted from the brain identified the causative agent as Spirometra mansoni. Homology search of the polymerase chain reaction (PCR)-amplified products from the case was conducted against gene fragments from local wild frogs. High homology was found between them, showing her likely exposure was frog consumption.


Assuntos
Encefalopatias/parasitologia , Esparganose/diagnóstico , Esparganose/parasitologia , Animais , Encefalopatias/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Esparganose/cirurgia , Spirometra/isolamento & purificação
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