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1.
Radiol Clin North Am ; 57(6): 1177-1188, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31582043

RESUMO

Advances in imaging techniques, such as MR perfusion and spectroscopy, are increasingly indispensable in the management and treatment plans of brain neoplasms: from diagnosing, molecular/genetic typing and grading neoplasms, augmenting biopsy results and improving accuracy, to ultimately directing and monitoring treatment and response. New developments in treatment methods have resulted in new diagnostic challenges for conventional MR imaging, such as pseudoprogression, where MR perfusion has the widest current application. MR spectroscopy is showing increasing promise in noninvasively determining genetic subtypes and, potentially, susceptibility to molecular targeted therapies.


Assuntos
Neoplasias Encefálicas/diagnóstico por imagem , Imagem por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Encéfalo/diagnóstico por imagem , Humanos , Imagem de Perfusão/métodos
2.
ABC., imagem cardiovasc ; 32(4): 309-317, out.-dez. 2019. ilus, graf
Artigo em Português | LILACS | ID: biblio-1023941

RESUMO

As neoplasias cardíacas são divididas em primárias e secundárias. As secundárias são 20 a 40 vezes mais comuns do que as primárias. Embora raras, as neoplasias cardíacas primárias podem ser benignas e malignas, sendo as benignas responsáveis por 75% dos casos. Os principais objetivos da imagem cardiovascular são definir a morfologia e etiologia do tumor, identificar potenciais complicações e auxiliar na definição de tratamento. Para o diagnóstico de neoplasias cardíacas, a tomografia por emissão de pósitrons acoplada à tomografia computadorizada (PET-TC) com a fluordesoxiglicose-F18 (18F-FDG) é uma técnica ainda pouco utilizada, principalmente nos tumores cardíacos primários. Entretanto, ela pode ajudar na diferenciação entre tumores malignos e benignos e, assim, evitar biópsias cardíacas e tratamentos invasivos desnecessários. Para esta revisão, realizamos pesquisa na base de dados PubMed, considerando as publicações sobre o tema nos últimos 10 anos. A PET-TC 18F-FDG é um exame útil para diferenciar massas cardíacas benignas das malignas, de acordo com o maior grau de metabolismo glicolítico encontrado nas neoplasias malignas. Além do mais, nos tumores malignos, a PET-TC 18F-FDG tem papel central no estadiamento da doença e pode ajudar na avaliação de resposta ao tratamento


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Diagnóstico por Imagem/métodos , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos , Neoplasias Cardíacas/diagnóstico , Sarcoma , Glicemia , Ecocardiografia/métodos , Espectroscopia de Ressonância Magnética/métodos , Doenças Cardiovasculares/diagnóstico , Compostos Radiofarmacêuticos , Fluordesoxiglucose F18 , Linfoma
4.
J Agric Food Chem ; 67(34): 9667-9682, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31415166

RESUMO

This study assessed the feasibility of an NMR metabolomics approach coupled to multivariate data analysis to monitor the naturally present or stresses-elicited metabolites from a long-term (>170 days) culture of the dinoflagellate marine microalgae Amphidinium carterae grown in a fiberglass paddlewheel-driven raceway photobioreactor. Metabolic contents, in particular, in two members of the amphidinol family, amphidinol A and its 7-sulfate derivative amphidinol B (referred as APDs), and other compounds of interest (fatty acids, carotenoids, oxylipins, etc.) were evaluated by altering concentration levels of the f/2 medium nutrients and daily mean irradiance. Operating with a 24 h sinusoidal light cycle allowed a 3-fold increase in APD production, which was also detected by an increase in hemolytic activity of the methanolic extract of A. carterae biomass. The presence of APDs was consistent with the antitumoral activity measured in the methanolic extracts of the biomass. Increased daily irradiance was accompanied by a general decrease in pigments and an increase in SFAs (saturated fatty acids), MUFAs (monounsaturated fatty acids), and DHA (docosahexaenoic acid), while increased nutrient availability lead to an increase in sugar, amino acid, and PUFA ω-3 contents and pigments and a decrease in SFAs and MUFAs. NMR-based metabolomics is shown to be a fast and suitable method to accompany the production of APD and bioactive compounds without the need of tedious isolation methods and bioassays. The two APD compounds were chemically identified by spectroscopic NMR and spectrometric ESI-IT MS (electrospray ionization ion trap mass spectrometry) and ESI-TOF MS (ESI time-of-flight mass spectrometry) methods.


Assuntos
Dinoflagelados/metabolismo , Macrolídeos/química , Espectroscopia de Ressonância Magnética/métodos , Metabolômica/métodos , Microalgas/metabolismo , Carotenoides/química , Carotenoides/metabolismo , Dinoflagelados/química , Ácidos Graxos/química , Ácidos Graxos/metabolismo , Macrolídeos/metabolismo , Microalgas/química , Análise Multivariada
6.
Phys Chem Chem Phys ; 21(34): 18422-18457, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31410425

RESUMO

Our review addresses how material properties emerge from atomistic-level interactions in the case of lipid membrane nanostructures. We summarize advances in solid-state nuclear magnetic resonance (NMR) spectroscopy in conjunction with alternative small-angle X-ray and neutron scattering methods for investigating lipid flexibility and dynamics. Solid-state 2H NMR is advantageous in that it provides atomistically resolved information about the order parameters and mobility of phospholipids within liquid-crystalline membranes. Bilayer deformation in response to external perturbations occurs over a range of length scales and allows one to disentangle how the bulk material properties emerge from atomistic forces. Examples include structural parameters such as the area per lipid and volumetric thickness together with the moduli for elastic deformation. Membranes under osmotic stress allow one to further distinguish collective undulations and quasielastic contributions from short-range noncollective effects. Our approach reveals how membrane elasticity involves length scales ranging from the bilayer dimensions on down to the size of the flexible lipid segments. Collective lipid interactions of the order of the bilayer thickness and less occur in the liquid-crystalline state. Emergence of lipid material properties is significant for models of lipid-protein forces acting on the mesoscopic length scale that play key roles in biomembrane functions.


Assuntos
Bicamadas Lipídicas/química , Espectroscopia de Ressonância Magnética/métodos , Nanoestruturas/química , Fosfolipídeos/química , Membrana Celular/química , Elasticidade , Cristais Líquidos/química , Proteínas de Membrana/química , Modelos Químicos , Nêutrons , Pressão Osmótica , Espalhamento de Radiação , Termodinâmica , Raios X
7.
Undersea Hyperb Med ; 46(3): 291-297, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31394599

RESUMO

Introduction: We evaluated magnetic resonance spectroscopy (MRS) in United States military personnel with persistent symptoms after mild traumatic brain injury (mTBI), comparing over time two groups randomized to receive hyperbaric oxygen or sham chamber sessions and a third group of normative controls. Methods: Active-duty or veteran military personnel and normative controls underwent MRS outcome measures at baseline, 13 weeks (mTBI group only), and six months. Participants received 3.0 Tesla brain MRS for analysis of water-suppressed two-dimensional (2D) multivoxel 1H-MRS of the brain using point resolved spectroscopy (PRESS) with volume selection localized above the lateral ventricles and within the brain parenchyma, of which one voxel was chosen in each hemisphere without artifact. Script-based automatic data processing was used to assess N-acetylaspartate (NAA), creatine (Cr), and choline (Cho). Metabolite ratios for white matter were then calculated for NAA/Cr (Area), Cho/Cr (Area), and Cho/NAA (Area). These ratios were compared using standard analysis methodology. Results: There were no observable differences between participants with mTBI and normative controls nor any observable changes over time in the NAA/Cr (area), Cho/Cr (area), and Cho/NAA (area) ratios. Similarly, the control and injured participants were indistinguishable. Discussion: While participants with mild TBI showed no difference in MRS compared to normative controls, our results are limited by the few voxels chosen and potentially by less sensitive MRS markers.


Assuntos
Ácido Aspártico/análogos & derivados , Química Encefálica , Concussão Encefálica/metabolismo , Colina/análise , Creatina/análise , Espectroscopia de Ressonância Magnética/métodos , Adulto , Ácido Aspártico/análise , Concussão Encefálica/terapia , Estudos de Casos e Controles , Feminino , Humanos , Oxigenação Hiperbárica , Ventrículos Laterais/química , Masculino , Militares , Síndrome Pós-Concussão/metabolismo , Fatores de Tempo , Veteranos
8.
J Agric Food Chem ; 67(36): 10265-10272, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31423777

RESUMO

Infant formula (IF), regarded as the optimal substitute for human breast milk, is very important for infant growth and development. Phospholipids (PLs) are ubiquitous components of infant formula as they have good emulsifier properties in addition to their nutritional and biological functions. In this study, the PL contents in four different commercial IF brands (indicated as A, M, O, and W) were characterized and quantified using optimized 31P NMR spectroscopy. PLs (nine) were identified and quantified, and among these, phosphatidylethanolamine and sphingomyelin occurred at lower concentrations (5.72 and 8.89 mg/100 g, respectively) in IFs from brand O, whereas phosphatidic acid was higher (2.83 mg/100 g) in IFs from brand W. In summary, 31P NMR spectroscopy, combined with the multivariate data analysis, proved to be an effective analytical toolbox for evaluating the PL contents in IF and the comparative differences between IF brands.


Assuntos
Fórmulas Infantis/química , Espectroscopia de Ressonância Magnética/métodos , Fosfolipídeos/química , Pós/química
10.
J Enzyme Inhib Med Chem ; 34(1): 1218-1225, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31286785

RESUMO

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and demonstrate its general applicability in studies of fragment-sized ligands binding to six different proteins (glycogen phosphorylase, protein peroxiredoxin 5, Bcl-xL, Mcl-1, HSP90, and human serum albumin). We compare the WaterLOGSY results to those obtained from the more widely used saturation transfer difference experiments and to the 3D structures of the complexes when available. In addition, we evaluate the impact of ligand labile protons on the WaterLOGSY data. Our results demonstrate that the WaterLOGSY experiment can be used as an additional confirmation of the binding mode of a ligand to a protein.


Assuntos
Descoberta de Drogas/métodos , Espectroscopia de Ressonância Magnética/métodos , Sítios de Ligação , Proteínas/química
11.
Chem Commun (Camb) ; 55(66): 9797-9800, 2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31360962

RESUMO

Molecular tubes with hydrogen bonding donors in their deep hydrophobic cavities are able to selectively bind organophosphorus compounds in water through hydrogen bonding and the hydrophobic effect. They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase.


Assuntos
Acetilcolinesterase/efeitos dos fármacos , Inibidores da Colinesterase/química , Inibidores da Colinesterase/toxicidade , Agentes Neurotóxicos/química , Agentes Neurotóxicos/toxicidade , Paraoxon/química , Paraoxon/toxicidade , Calorimetria , Corantes Fluorescentes/química , Ligações de Hidrogênio , Interações Hidrofóbicas e Hidrofílicas , Espectroscopia de Ressonância Magnética/métodos , Termodinâmica , Água/química
12.
J Agric Food Chem ; 67(31): 8425-8430, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31322874

RESUMO

In recent years, non-targeted methods have been a popular "buzz" phrase in food fraud detection. Using analytical instrumentation techniques, non-targeted methods have been developed and applied in many food and agricultural situations. However, confusion and misstatements remain regarding how the methods are used. This perspective will discuss the definitions related to non-targeted testing, the procedure of developing and validating methods, the techniques and data analysis, and opportunities and challenges regarding the use of this class of analytical methods. The perspective seeks to provide readers with the latest information regarding recent advances in the use of non-targeted methods.


Assuntos
Análise de Alimentos/métodos , Contaminação de Alimentos/análise , Cromatografia Líquida/métodos , Eletroforese Capilar/métodos , Análise de Alimentos/instrumentação , Humanos , Espectroscopia de Ressonância Magnética/métodos , Espectrometria de Massas/métodos
13.
J Agric Food Chem ; 67(29): 8107-8118, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31260291

RESUMO

Humic substances (HS) are vital to soil fertility and carbon sequestration. Using multiple cross-polarization/magic-angle spinning (multiCP/MAS) NMR combined with dipolar dephasing, we quantitatively characterized humic fractions, i.e., fulvic acid (FA), humic acid (HA), and humin (HM), isolated from two representative soils (upland and paddy soils) in China under six long-term (>20 years) fertilizer treatments. Results indicate that each humic fraction showed chemical distinction between the upland and paddy soils, especially with much greater aromaticity of upland HMs than of paddy HMs. Fertilizer treatment exerted greater influence on chemical natures of upland HS than of paddy HS, although the effect was less than that of soil type. Organic manure application especially decreased the percentages of aromatic C in the upland HAs and HMs compared with the control. We concluded that humic fractions responded in chemical nature to environmental conditions, i.e., soil type/cropping system/soil aeration and fertilizer treatments.


Assuntos
Substâncias Húmicas/análise , Espectroscopia de Ressonância Magnética/métodos , Solo/química , Carbono/análise , China , Fertilizantes/análise , Esterco/análise , Oryza/crescimento & desenvolvimento , Oryza/metabolismo
15.
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(3 Supl): 324-37, jul.-set. 2019. ilus
Artigo em Português | LILACS | ID: biblio-1023253

RESUMO

A endomiocardiofibrose é uma cardiopatia restritiva, pouco comum, com descrição recente. Foi descrita pela primeira vez em 1938, por Williams e estudada do ponto de vista anatomopatológico pelo patologista Davies, na África do Sul, recebendo o epônimo Doença de Davies em 1948. Considerando a história natural dessa doença, há maior incidência de diagnósticos nas terceiras e quartas décadas da vida, com média de 32 anos. Queremos chamar a atenção da comunidade científica, relatando o caso de uma senhora com diagnóstico inicial de endomiocardiofibrose aos 90 anos e indagar sobre a incidência e o subdiagnóstico dessa doença, bem como sua evolução


Endomyocardial fibrosis is a rare, recently-described, restrictive cardiopathy. It was first described in 1938 by Williams and studied from an anatomopathological perspective by pathologist Davies in South Africa, receiving the eponym Davies Disease in 1948. In terms of the natural history of this disease, there is a higher incidence of diagnoses in the third and fourth decades of life, at a mean age of 32 years. We want to raise the awareness of the scientific community by reporting the case of a woman who was first diagnosed with endomyocardial fibrosis at 90 years of age and pose questions about the incidence and subdiagnosis of this disease, as well as about its evolution


Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Idoso de 80 Anos ou mais , Fibrose Endomiocárdica/história , Insuficiência Cardíaca , Ecocardiografia/métodos , Espectroscopia de Ressonância Magnética/métodos , Fatores Sexuais , Extremidade Inferior , Endocárdio , Átrios do Coração , Cardiopatias , Ventrículos do Coração
16.
Eur J Radiol ; 116: 205-211, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31153566

RESUMO

PURPOSE: To assess the association of fatty acid levels in mammary adipose tissue of postmenopausal women with the presence of breast cancer using the Gradient-echo Spectroscopic Imaging (GSI). MATERIALS AND METHODS: Unilateral GSI was performed at 3 T in 61 postmenopausal women undergoing breast MRI exams. The study included 19 women with breast cancer, 23 women with benign/high risk lesions, and 19 women with a history of cancer. Voxel-wise spectral analysis of fatty acids was conducted to measure relative portions of monounsaturated (MUFA), polyunsaturated (PUFA), and saturated fatty acids (SFA) in each voxel. The voxels within mammary adipose tissue were automatically selected and their median fatty acid fractions were used for quantitative analysis. Statistical analyses were performed using χ2 test, one-way analysis of variance (ANOVA) with Tukey-Kramer multiple comparison tests, and linear regression. RESULTS: Postmenopausal women with malignancies had significantly higher SFA (0.336 ± 0.038) in mammary adipose tissue compared to those with benign disease (0.283 ± 0.046, p = 0.0008) and to those with a history of breast cancer (0.287 ± 0.050, p = 0.0038). Postmenopausal women with malignant lesions had significantly lower MUFA (0.352 ± 0.041) compared to those with benign disease (0.401 ± 0.043, p = 0.0032) and with history of breast cancer (0.388 ± 0.055, p = 0.0484). The history of cancer group had a significant correlation (r = 0.60, p = 0.006) between SFA and BMI, and the cancer group had a significant correlation (r = 0.57, p = 0.010) between PUFA and BMI. CONCLUSIONS: Fatty acid composition of mammary adipose tissue, particularly higher SFA and lower MUFA, may be associated with breast cancer. The GSI method utilizes an automated voxel-based analysis to measure fatty acid composition, and may be used to assess the role of mammary adipose tissue in cancer development and progress.


Assuntos
Tecido Adiposo/química , Neoplasias da Mama/metabolismo , Mama/química , Ácidos Graxos/metabolismo , Feminino , Humanos , Imagem por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Pessoa de Meia-Idade , Pós-Menopausa/fisiologia , Estudos Retrospectivos
17.
J Agric Food Chem ; 67(27): 7765-7774, 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31240917

RESUMO

One of the greatest challenges facing the functional food and natural health product (NHP) industries is sourcing high-quality, functional, natural ingredients for their finished products. Unfortunately, the lack of ingredient standards, modernized analytical methodologies, and industry oversight creates the potential for low quality and, in some cases, deliberate adulteration of ingredients. By exploring a diverse library of NHPs provided by the independent certification organization ISURA, we demonstrated that nuclear magnetic resonance (NMR) spectroscopy provides an innovative solution to authenticate botanicals and warrant the quality and safety of processed foods and manufactured functional ingredients. Two-dimensional NMR experiments were shown to be a robust and reproducible approach to capture the content of complex chemical mixtures, while a binary normalization step allows for emphasizing the chemical diversity in each sample, and unsupervised statistical methodologies provide key advantages to classify, authenticate, and highlight the potential presence of additives and adulterants.


Assuntos
Rotulagem de Medicamentos/métodos , Processamento Eletrônico de Dados/métodos , Rotulagem de Alimentos/métodos , Alimento Funcional/análise , Espectroscopia de Ressonância Magnética/métodos , Preparações de Plantas/análise , Manipulação de Alimentos , Rotulagem de Alimentos/normas , Qualidade dos Alimentos , Inocuidade dos Alimentos , Análise Multivariada , Controle de Qualidade
18.
Gac. méd. boliv ; 42(1): 79-83, jun. 2019. ilus.
Artigo em Inglês | LILACS, LIBOCS | ID: biblio-1007010

RESUMO

El síndrome de encefalopatía reversible posterior (PRES), es una entidad clínico radiológica caracterizada por déficit neurológico, convulsiones, pudiendo llegar a un estado de coma. Requiere diagnóstico por imagen para evidencia de edema vasogénico proceso fisiopatológico reversible, apoyados por tomografía computarizada o resonancia magnética, esta última con mayor sensibilidad para diferenciarla del edema citotóxico que es irreversible. Fisiopatológicamente está asociada a mala autorregulación cerebral secundaria varios factores, en este caso, preeclampsia grave, donde destaca el compromiso clínico e imagenológico del tronco encefálico. La instauración de un tratamiento adecuado y oportuno permite visualizar la regresión de las lesiones, que de no ser así terminaran infartándose.


The posterior reversible encephalopathy syndrome (PRES) is a clinical radiological entity characterized by neurological deficit, seizures, and may reach a coma. It requires diagnostic imaging for evidence of vasogenic edema reversible pathophysiological process, supported by computerized tomography or magnetic resonance, the latter with greater sensitivity to differentiate it from cytotoxic edema that is irreversible. Pathophysiologically, several factors are associated with poor cerebral self-regulation, in this case, severe preeclampsia, which highlights the clinical and imaging involvement of the brainstem. The establishment of an appropriate and timely treatment allows visualizing the regression of the lesions, which otherwise would end up infracting.


Assuntos
Humanos , Feminino , Gravidez , Adulto , Pré-Eclâmpsia/diagnóstico por imagem , Espectroscopia de Ressonância Magnética/métodos , Síndrome HELLP/diagnóstico por imagem , Acidente Vascular Cerebral
19.
Planta Med ; 85(11-12): 941-946, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31163460

RESUMO

Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3',4'-trihydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1: ), together with two known p-cymene derivatives (2: and 3: ), as well as five known compounds, namely, thymol (4: ), oleanolic acid (5: ), ursolic acid (6: ), cirsimaritin (7: ), and xanthomicrol (8: ). The structural elucidation of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR, and HRESIMS experiments. The biphenyls were assayed for their inhibitory activity on tyrosinase. Compounds 2: and 3: showed negligible activity on tyrosinase, while compound 1: effectively inhibited the enzyme with 35% (± 0.3) inhibitory activity, higher than the inhibition of the reference compound kojic acid (18.6 ± 0.02).


Assuntos
Cromatografia Gasosa-Espectrometria de Massas/métodos , Espectroscopia de Ressonância Magnética/métodos , Monofenol Mono-Oxigenase/antagonistas & inibidores , Monoterpenos/isolamento & purificação , Extratos Vegetais/química , Thymus (Planta)/química , Flavonas/farmacologia , Monoterpenos/farmacologia , Ácido Oleanólico/farmacologia , Timol/farmacologia , Triterpenos/farmacologia
20.
Eur J Radiol ; 116: 55-60, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31153574

RESUMO

OBJECTIVE: To determine the changes in fractional anisotropy (FA) at the proximal spinal cord and in magnetic resonance spectroscopy (MRS) of the precentral gyrus in patients with cervical spondylotic myelopathy (CSM) with respect to clinical symptoms and their duration. MATERIAL AND METHODS: 20 patients with CSM (7 female; mean age 64.6 ± 10.5 years) and 18 age/sex matched healthy controls (9 female; mean age 63.5 ± 6.6 years) were prospectively included. Clinical data (modified Japanese Orthopaedic Association Score (mJOA) and Neck Disability Index (NDI)) and 3T MR measurements including DTI at the spinal cord (level C2/3) with FA and MRS of the left and right precentral gyrus were taken. Clinical correlations and regression analyses were performed. RESULTS: Mean clinical scores of patients were significantly different to controls (mJOA; CSM: 10.2 ± 2.9; controls: 18.0 ± 0.0, p < 0.001; NDI; CSM: 41.4±23.5; controls: 4.4±6.6, p<0.001); FA was significantly lower in patients (CSM: 0.645 ± 0.067; controls: 0.699 ± 0.037, p = 0.005). MRS showed significantly lower metabolite concentrations between both groups: creatine (Cr) (CSM: 46.46±7.64; controls: 51.36±5.76, p = 0.03) and N-acetylaspartate (NAA) (CSM: 93.94±19.22; controls: 107.24±20.20, p = 0.05). Duration of symptoms ≤6 months was associated with increased myo-inositol (Ins) (61.58±17.76; 44.44±10.79; p = 0.02) and Ins/Cr ratio (1.36±0.47; 0.96±0.18; p = 0.014) compared to symptoms >6 months. CONCLUSION: Metabolic profiles of the precentral gyrus and FA in the uppermost spinal cord differ significantly between patients and healthy controls. Ins, thought to be a marker of endogenous neuroinflammatory response, is high in the early course of CSM and normalizes over time.


Assuntos
Espectroscopia de Ressonância Magnética/métodos , Córtex Motor/diagnóstico por imagem , Córtex Motor/metabolismo , Doenças da Medula Espinal/patologia , Espondilose/patologia , Idoso , Anisotropia , Ácido Aspártico/análogos & derivados , Ácido Aspártico/metabolismo , Biomarcadores/metabolismo , Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/patologia , Creatina/metabolismo , Feminino , Humanos , Inositol/metabolismo , Masculino , Pessoa de Meia-Idade , Córtex Motor/patologia , Doenças da Medula Espinal/metabolismo , Espondilose/metabolismo , Fatores de Tempo
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