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2.
Orv Hetil ; 160(42): 1673-1676, 2019 Oct.
Artigo em Húngaro | MEDLINE | ID: mdl-31608690

RESUMO

Capgras symptom is characterized by the delusional belief that a person significant to the patient has been replaced by a 'double' or 'impostor'. Capgras symptom was discussed to be associated with violent behavior. We report here the cases of two male patients with schizophrenia paranoid type, where parricide was connected to Capgras delusion. It is important to emphasize that in our observed cases, non-adherence played an essential role in the development of violent behavior, parricide. Orv Hetil. 2019; 160(42): 1673-1676.


Assuntos
Síndrome de Capgras/complicações , Homicídio , Esquizofrenia Paranoide/etiologia , Violência/psicologia , Adulto , Síndrome de Capgras/diagnóstico , Síndrome de Capgras/psicologia , Delusões/psicologia , Pai , Humanos , Masculino , Esquizofrenia Paranoide/diagnóstico , Esquizofrenia Paranoide/psicologia
3.
Fortschr Neurol Psychiatr ; 87(12): 695-701, 2019 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-31390658

RESUMO

GOAL: The aim of the study was to investigate delusions of poisoning in people with paranoid schizophrenia. Specifically, how often delusions of poisoning occur, how the delusional content is represented and to what extent women and men differ in delusions of poisoning were analysed. METHODS & SAMPLE: Data were collected retrospectively from two psychiatric wards in Germany. Base material comprised the medical records of all persons receiving inpatient treatment due to their paranoid schizophrenia between 2010 and 2014 in one of the two psychiatric wards. The sample consisted of 156 people (96 women, 60 men) diagnosed with paranoid schizophrenia showing delusions of poisoning. RESULTS: Delusions of poisoning were a common delusional theme which significantly more often occurred in women than in men. Moreover, women were significantly more likely to have delusions of persecution in addition to their delusions of poisoning. Overall, people with delusions of poisoning often reported being poisoned by close relatives or health workers. Most of those affected assumed that poisoning was carried out through medication, food or drinks.


Assuntos
Delusões , Envenenamento , Esquizofrenia Paranoide , Feminino , Alemanha , Humanos , Masculino , Envenenamento/psicologia , Estudos Retrospectivos , Esquizofrenia Paranoide/psicologia , Psicologia do Esquizofrênico
4.
Psychopathology ; 52(1): 50-58, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31085924

RESUMO

Delusional disorder (DD) is still considered a diagnosis of exclusion for a difficult-to-treat condition characterised by the presence of delusional beliefs in the absence of other psychiatric symptoms. Attempts to contextualise psychological processes recognised since the earliest observations of this disorder have had very limited impact on improving some fixed beliefs. In the Cambridge Early Intervention in Psychosis Service we have observed a particular phenomenon, often categorised as a delusional idea in the context of DD, which manifests through highly repetitive belief expression that fails to respond to pharmacological and psychological treatments. Key aspects of this phenomenon are similar to those observed in dissociative (functional neurological) presentations. Drawing on the Integrative Cognitive Model of functional neurological disorders, we developed a successful psychological intervention that places less emphasis on challenging delusional content and focuses more on dismantling dissociation and underlying affective factors associated with the activation of the fixed belief. Our initial findings reinforce the need to continue developing a multi-level phenomenological approach to define a variety of symptoms traditionally grouped under the concept of "delusion."


Assuntos
Delusões/psicologia , Transtornos Dissociativos/psicologia , Esquizofrenia Paranoide/psicologia , Feminino , Humanos , Pessoa de Meia-Idade
5.
Clin Neuropharmacol ; 42(2): 64-65, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30747749

RESUMO

OBJECTIVE: Long-acting depot preparations of antipsychotics are the mainstay of treatment for patients with schizophrenia who show nonadherence to their medications. Olanzapine pamoate is one of the recently approved long-acting depot psychotropic preparations that have shown its efficacy both in clinical trials and in clinical uses against the illness. However, emerging literature indicates toward a cluster of adverse effects known as postinjection delirium/sedation syndrome (PDSS). METHODS: We here present a case of PDSS in a woman with paranoid schizophrenia. After maintaining well for almost 1½ years, she developed PDSS at her 31st scheduled long-acting olanzapine injection. RESULTS: Several features of PDSS including its mechanism and course have been discussed. CONCLUSIONS: More research is necessary to understand the syndrome and the association between PDSS and long-acting olanzapine injection. Clinicians should keep in mind that PDSS may worsen compliance in an index patient and affect the course of the illness.


Assuntos
Antipsicóticos/efeitos adversos , Delírio/induzido quimicamente , Hipnóticos e Sedativos/efeitos adversos , Olanzapina/efeitos adversos , Esquizofrenia Paranoide/tratamento farmacológico , Adulto , Antipsicóticos/administração & dosagem , Preparações de Ação Retardada/administração & dosagem , Preparações de Ação Retardada/efeitos adversos , Delírio/diagnóstico , Delírio/psicologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/psicologia , Feminino , Humanos , Hipnóticos e Sedativos/administração & dosagem , Olanzapina/administração & dosagem , Esquizofrenia Paranoide/diagnóstico , Esquizofrenia Paranoide/psicologia , Síndrome
7.
Asian J Psychiatr ; 39: 98-100, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30599452

RESUMO

Lesion-based investigations of psychopathology have preceded contemporary network-neuroscience initiatives. However, brain-lesions detected in routine psychiatric practice are often considered incidental and therefore ignored. Here, we illustrate a strategy to combine individual subject-level lesion information with open-source normative functional-connectomics data to make putative, neuroscience-informed symptom interpretation. Specifically, we report a patient with left precuneus granulomatous lesion and seizures followed by two distinct symptoms - kinetopsia and delusions of nihilism and guilt - which had a differential treatment response. The lesion-based brain-mapping approach could identify correlated (default-mode) and anti-correlated (temporo-parieto-occipital) networks, which enabled a neurobiological formulation of these diverse clinical manifestations.


Assuntos
Neoplasias Encefálicas/complicações , Transtorno Depressivo Maior/complicações , Granuloma/complicações , Imagem por Ressonância Magnética/métodos , Lobo Parietal/diagnóstico por imagem , Esquizofrenia Paranoide/complicações , Anticonvulsivantes/uso terapêutico , Antidepressivos de Segunda Geração/uso terapêutico , Antipsicóticos/uso terapêutico , Mapeamento Encefálico/métodos , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/terapia , Transtorno Depressivo Maior/psicologia , Transtorno Depressivo Maior/terapia , Diagnóstico Diferencial , Eletroconvulsoterapia , Feminino , Fluoxetina/uso terapêutico , Granuloma/diagnóstico por imagem , Granuloma/terapia , Humanos , Pessoa de Meia-Idade , Fenitoína/uso terapêutico , Fumarato de Quetiapina/uso terapêutico , Esquizofrenia Paranoide/psicologia , Esquizofrenia Paranoide/terapia , Convulsões/complicações , Convulsões/tratamento farmacológico
8.
Encephale ; 45(2): 162-168, 2019 Apr.
Artigo em Francês | MEDLINE | ID: mdl-30309614

RESUMO

BACKGROUND: Currently, all of the studies that focus on the relationship between paranoia and criminal offenses exclusively concern subjects suffering from a delusional paranoid disorder. However, subjects with single paranoid personality disorder, without any associated delusional disorder, are not uncommon in forensic practice. OBJECTIVES: This study aims to describe the offenses committed by subjects suffering from a single paranoid personality disorder and to compare them with the offenses committed by the subjects affected by a paranoid delusional disorder associated with paranoid personality disorder. Our initial hypothesis is that both populations have a comparable criminological profile. METHODS: Based on a 17 year-long experience carried out in the framework of a forensic assessment, we have selected all subjects presenting a paranoid personality disorder, whether single or associated with paranoid delusional disorder. The selected individuals were divided into two groups according to whether they presented paranoid delusional disorder or not. The offenses were grouped into criminal categories. The alpha risk was fixed at 1%. Data analysis is done by SAS software version 9.4. RESULTS: In a sample of 106 subjects presenting a paranoid personality disorder, including 4 women and 102 men, we found 79 subjects with a single paranoid personality and 27 with an associated paranoid delusional disorder. The average age at the time of the offense was 41 for those with single personality disorders and 49 for those with paranoid delusional disorders. Both groups had forensic antecedents (41%, 11/27 of paranoid delusional disorder and 51%, 40/79 of single paranoid personality disorder). Psychiatric history was more frequent in the paranoid delusional disorder group (59%, 16/27) than in the single paranoid personality disorder group (13%, 10/79). History of addiction was comparable in terms of alcohol abuse (26% in both groups) and other substances (7.5%, 2/27 of paranoid delusional disorder and 9%, 7/79 of single paranoid personality disorder). Comparison of the two groups highlighted significant differences in the type of criminal offenses committed (Fisher's exact test: P=0.0003, alpha risk <0.0001). The offenses committed by delusional authors essentially came down to verbal or physical violence, including homicide (44%, 12/27), and were usually focused on a designated persecutor. Sexual violence was rare. On the other hand, paranoid personality disorder was associated with a wider variety of offenses. Sexual offenses (including 28 rapes, 35%, 28/79) were thus almost as frequent as murder, and attempted murder (38%, 30/79). This diversity of committed offenses was found in their forensic antecedents. In these subjects, the logic of omnipotence may had over ruled the logic of revenge. CONCLUSION: We conducted a retrospective study on 106 subjects with paranoid personality disorder, including 27 subjects with associated paranoid delusional disorder. The comparison of the two groups demonstrated significant differences in offenses. Verbal and physical but non-sexual violence, committed in a delusional logic, was found among delusional subjects, while the forms of violence were more multiform in the single paranoid personality disorder group, frequently including sexual violence. This is, as far as we know, the first study describing the medico-legal acting-out of paranoid personalities. These results, which will need to be confirmed by future studies, point out the importance of the criminological risk that may be associated with paranoid personality disorder, without any associated delusional disorder.


Assuntos
Crime/psicologia , Crime/estatística & dados numéricos , Transtorno da Personalidade Paranoide/epidemiologia , Violência/psicologia , Violência/estatística & dados numéricos , Adulto , Alcoolismo/epidemiologia , Alcoolismo/psicologia , Criminosos/psicologia , Criminosos/estatística & dados numéricos , Feminino , França/epidemiologia , Homicídio/psicologia , Homicídio/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Transtorno da Personalidade Paranoide/psicologia , Transtornos da Personalidade/epidemiologia , Transtornos da Personalidade/psicologia , Estudos Retrospectivos , Esquizofrenia Paranoide/epidemiologia , Esquizofrenia Paranoide/psicologia , Delitos Sexuais/psicologia , Delitos Sexuais/estatística & dados numéricos
9.
Integr Psychol Behav Sci ; 53(3): 525-540, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30430374

RESUMO

Instead of considering procrastination as a unitary construct we argue that it takes different forms and has multiple explanations and determinants. While it is fair to consider procrastination a cognitive focusing issue, we posit that the motivational sources for this vary depending on where someone can be located with regard to the "existential" developmental positions that have been explicated over many years by Object Relations clinical theorists: the autistic-contiguous, paranoid-schizoid, depressive, and transcendental. These positions generate different understandings of what motivates procrastination and in turn, effects the interventions we offer. We note both clinical and commonplace examples.


Assuntos
Procrastinação , Transtorno Autístico/psicologia , Aprendizagem da Esquiva , Depressão/psicologia , Desenvolvimento Humano , Humanos , Modelos Psicológicos , Apego ao Objeto , Procrastinação/classificação , Esquizofrenia Paranoide/psicologia , Volição
10.
Eur Psychiatry ; 55: 52-60, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30388425

RESUMO

BACKGROUND: Even if neurocognition is known to affect functional outcomes in schizophrenia, no previous study has explored the impact of cognition on functionality in delusional disorder (DD). We aimed to assess the effect of clinical characteristics, symptom dimensions and neuropsychological performance on psychosocial functioning and self-perceived functional impairment in DD. METHODS: Seventy-five patients with a SCID-I confirmed diagnosis of DD underwent neurocognitive testing using a neuropsychological battery examining verbal memory, attention, working memory and executive functions. We assessed psychotic symptoms with the Positive and Negative Syndrome Scale, and calculated factor scores for four clinical dimensions: Paranoid, Cognitive, Affective and Schizoid. We conducted hierarchical linear regression models to identify predictors of psychosocial functioning, as measured with the Global Assessment of Functioning scale, and self-perceived functional impairment, as measured with the Sheehan's Disability Inventory. RESULTS: In the final linear regression models, higher scores in the Paranoid (ß= 0.471, p < .001, r2 = 0.273) and Cognitive (ß = 0.325, p < .001, r2 = 0.180) symptomatic dimensions and lower scores in verbal memory (ß = -0.273, p < .05, r2 = 0.075) were significantly associated with poorer psychosocial functioning in patients with DD. Lower scores in verbal memory (ß= -0.337, p < .01, r2 = 0.158) and executive functions (ß= -0.323, p < .01, r2 = 0.094) were significantly associated with higher self-perceived disability. CONCLUSIONS: Impaired verbal memory and cognitive symptoms seem to affect functionality in DD, above and beyond the severity of the paranoid idea. This suggests a potential role for cognitive interventions in the management of DD.


Assuntos
Atenção , Cognição , Função Executiva , Transtornos Paranoides , Transtornos Psicóticos , Esquizofrenia Paranoide , Adulto , Terapia Cognitivo-Comportamental/métodos , Avaliação da Deficiência , Feminino , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Testes Neuropsicológicos , Transtornos Paranoides/diagnóstico , Transtornos Paranoides/etiologia , Transtornos Paranoides/terapia , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/etiologia , Transtornos Psicóticos/terapia , Esquizofrenia Paranoide/diagnóstico , Esquizofrenia Paranoide/psicologia , Esquizofrenia Paranoide/terapia , Autoavaliação , Habilidades Sociais
11.
Early Interv Psychiatry ; 13(4): 780-788, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-29521010

RESUMO

AIM: Early intervention programmes for first episode psychosis (FEP) aim to reduce the duration of untreated psychosis (DUP) and improve functional outcomes. The sustained maintenance of improved outcomes depends largely on patients' adherence to prescribed treatment. This paper examines the prevalence of non-adherence in a cohort of patients with FEP and the sociodemographic and clinical factors associated with non-adherent behaviour. METHODS: The sample included consecutive patients accepted from 2007 to 2012 into the Early Psychosis Intervention Programme (EPIP) in Singapore. Sociodemographic variables as well as DUP, insight, severity of psychopathology and clinical diagnoses were collected. Patients were assessed at baseline and 1 year with the PANSS and Global Assessment of Functioning Scale (GAF). Medication adherence was grouped into 3 categories: no-adherence, partial adherence and regular adherence. RESULTS: Of the 445 patients included, 51% were male with a mean age of 26.3 years, 74.6% had schizophrenia spectrum and delusional disorders, 14% had affective psychosis and 11.3% had brief psychotic disorder or psychotic disorder not otherwise specified. At 1 year follow up, 65.5% reported regular adherence, 18.7% were partially adherent and 15.8% were non-adherent. Non-adherence was correlated with male gender, living alone and having poorer judgement and insight. Partial adherence was associated with Malay ethnicity and having undergone national service. CONCLUSION: Medication adherence is prevalent in FEP and associated with a variety of factors. This study supports the use of culturally appropriate interventions in addressing barriers to adherence. Further studies would need to be done to address specific factors affecting adherence outcomes.


Assuntos
Transtornos Psicóticos Afetivos/psicologia , Adesão à Medicação/psicologia , Transtornos Psicóticos/psicologia , Esquizofrenia Paranoide/psicologia , Adulto , Intervenção Médica Precoce/estatística & dados numéricos , Grupos Étnicos/psicologia , Feminino , Humanos , Masculino , Psicologia do Esquizofrênico , Singapura , Adulto Jovem
13.
Wiad Lek ; 71(7): 1392-1397, 2018.
Artigo em Russo | MEDLINE | ID: mdl-30448816

RESUMO

OBJECTIVE: Introduction: Suicidal behavior in schizophrenia is one of the most urgent problems of modern psychiatry. The aim of the study was to study the suicidal activity of patients with paranoid schizophrenia in the context of clinical symptoms. PATIENTS AND METHODS: Materials and methods: The medical documentation of 407 men and 409 women who were diagnosed as "paranoid schizophrenia" in the period 1967-2017 on the basis of the Vinnytsia Regional Psychoneurological Hospital was studied by the method of continuous analysis; the prevalence of separate symptoms was analyzed in accordance with the standard ICD-10 criteria in the context of the presence of suicidal thoughts and suicidal actions. RESULTS: Review and conclusions: The main clinical symptoms of paranoid schizophrenia, as well as certain additional symptoms (chronic hallucinatory and delusional symptoms, negative symptoms and behavioral changes) are associated with suicidal thoughts and suicidal actions; while in men with suicidal actions, a disturbance of the speech function and catatonic symptomatology are more often detected.


Assuntos
Esquizofrenia Paranoide/psicologia , Ideação Suicida , Tentativa de Suicídio , Delusões/psicologia , Feminino , Humanos , Masculino , Prevalência
14.
Psychiatry Res ; 270: 274-280, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30278408

RESUMO

Insight has long been linked to both prognosis and functioning in patients with schizophrenia; likewise, it is key to treatment adherence. This study seeks to assess the association between insight, adherence to pharmacological treatment, and disability in schizophrenia, and to study the potential mediating role of adherence between insight and disability. Insight (SUMD), adherence (CRS), and disability (WHO-DAS) were measured in 80 clinically stable patients with DSM-IV TR paranoid schizophrenia. Psychopathology was assessed with the Positive and Negative Syndrome Scale (PANSS). In a first step, predictors of disability were identified using linear regression to identify variables related to disability and further a mediation analysis was carried out. Negative symptoms, insight, and adherence account for 54.2% of the variance in disability. Negative symptoms act directly on disability, while the effect of insight on disability is partially mediated by adherence. Insight is key in disability in schizophrenia and should be leveraged in treatment programs.


Assuntos
Conscientização/fisiologia , Cooperação do Paciente/psicologia , Esquizofrenia Paranoide/fisiopatologia , Esquizofrenia Paranoide/psicologia , Psicologia do Esquizofrênico , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
16.
Int J Law Psychiatry ; 60: 1-11, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30217324

RESUMO

This cross sectional study aimed to compare the differences in psychopathology of Greek homicide and homicide attempters, patients with schizophrenia, with non violent individuals, suffering from schizophrenia. The study compared three Groups of 220 men, diagnosed with schizophrenia: (a) Group Α (Schizophrenia - No violence, (b) Group Β (Schizophrenia - with violence or violent crime), (c) Group C (Schizophrenia - not guilty by reason of insanity - violent crime). Several psychometric tools were used, such as M.I.N·I (Mini-International Neuropsychiatric Interview), PANSS scale (Positive and Negative Symptoms Scale). Most subjects suffered from paranoid schizophrenia. On factors such as demographic characteristics (i.e. current occupational status, living status), statistically significant findings were shown for Groups B and C vs Group A. Predisposing psychosocial factors, such as family conflicts and aggressiveness against family, were found to be statistically significant in differentiating violent versus nonviolent individuals with psychosis. They differed significantly in factors like history of juvenile delinquency, but also in the type of aggressiveness in general. These differences were confirmed on PANSS scale. In conclusion, the longer the history of aggressiveness is presented, the greater the chances are of individuals falling into Group C and it is possible to spend several years from the onset of the disease until the moment of crime.


Assuntos
Agressão , Comportamento Perigoso , Demografia , Esquizofrenia Paranoide/psicologia , Transtornos Relacionados ao Uso de Substâncias , Adulto , Estudos Transversais , Demografia/estatística & dados numéricos , Homicídio , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica
18.
Z Kinder Jugendpsychiatr Psychother ; 46(6): 536-541, 2018 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-30084713

RESUMO

Electroconvulsive Therapy (ECT) of a 15-year-old female patient suffering from a severe delusional depression: a case report Abstract. OBJECTIVE: Electroconvulsive Therapy (ECT) is a modern therapy of severe psychiatric disorders. However, ECT is rarely used in treating children and adolescents with psychiatric disorders. This case report refers about a 15-year-old female patient suffering from severe depressive episodes with psychotic symptoms treated with ECT. METHOD: After unsuccessful combined behavioral therapy and medication, the patient received a total of 11 ECT treatments with right unilateral electrode placement. The severity of depressive symptoms was assessed by self (BDI-II) and external (HDRS21) scores before, during and after treatment. RESULTS: A rapid decline of depressive symptoms was observed. CONCLUSION: ECT provides a safe and effective method for the treatment of severe depressive disorders in childhood and adolescence and should be included earlier than usual into the standard therapeutic concepts.


Assuntos
Transtorno Depressivo Maior/terapia , Eletroconvulsoterapia , Esquizofrenia Paranoide/terapia , Adolescente , Terapia Combinada , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/psicologia , Feminino , Seguimentos , Humanos , Olanzapina/uso terapêutico , Admissão do Paciente , Esquizofrenia Paranoide/diagnóstico , Esquizofrenia Paranoide/psicologia , Tentativa de Suicídio/prevenção & controle , Tentativa de Suicídio/psicologia
19.
Psychiatr Pol ; 52(2): 251-259, 2018 Apr 30.
Artigo em Inglês, Polonês | MEDLINE | ID: mdl-29975365

RESUMO

Cervical cancer constitutes 5.32% of all malignant neoplasm cases, it is the sixth most common condition of the cancer type and it is an important problem because of its medical, epidemiological and social implications. The aim of primary prophylaxis is to reduce the number of new cases, while secondary prophylaxis is to provide early diagnoses and treatment of cancer cases. The aim of this work is to present the case of 55-year-old woman treated with chronic paranoid schizophrenia whose gynecologist refused to collect biological material for cytological evaluation. The patient was diagnosed with carcinoma planoepitheliale (G2), then treated surgically and qualified for adjuvant-radiological treatment. Despite the good mental state and a psychiatrists' statement (treating the patient for many years) of the absence of contraindications for hospitalization, a gynecologist-oncologist refused to admit the patient to the ward in fear of a threat to other patients and decided on outpatient palliative treatment of the patient. Finally, radiologist-oncologist performed the complete cycle of irradiation in order to cure the patient. While looking for possible reasons of cervical cancer development in individuals with psychotic disorders, all the possible carcinogenic factors have to be taken into account. Nulliparous women and virgins treated for mental illness must not be denied screening examinations related to cervical cancer. Despite the changes, also related to the implementation of the mental health program, people with mental disorders with underlying physical illness are still stigmatized, even by a higher medical personnel. Moreover, mentally ill patients are denied proper treatment in accordance with the current state of medical knowledge.


Assuntos
Atitude do Pessoal de Saúde , Recusa do Médico a Tratar , Esquizofrenia Paranoide/psicologia , Esquizofrenia , Neoplasias do Colo do Útero/diagnóstico , Feminino , Humanos , Competência Mental , Pessoa de Meia-Idade , Psicologia do Esquizofrênico
20.
Dermatol Ther ; 31(4): e12637, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30019366

RESUMO

Acneiform rash is a commonly reported side effect to certain types of medications, including antipsychotic agents. Its clinical presentation consists mainly of papulopustular lesions. Other types of lesions, such as nodular or cystic, can also be observed. Body distribution of the lesions follows a similar pattern to acne vulgaris. Depending on the severity of the case, drug-induced acne may be treated in different ways. In mild cases, the use of topical antibiotics and retinoids in combination is usually effective. With more severe forms, it may be necessary to add oral antibiotics, such as tetracyclines, but a good response is not always achieved. Identification of the drug responsible for the side-effect is mandatory in refractory eruptions. Herein, we present the case of an Aripiprazole-induced acneiform rash successfully treated with oral Isotretinoin. The treatment was effective and well tolerated and there was no need to discontinue the psychopharmacological medication. This is the first study to report this modality of treatment.


Assuntos
Erupções Acneiformes/tratamento farmacológico , Antipsicóticos/efeitos adversos , Aripiprazol/efeitos adversos , Fármacos Dermatológicos/administração & dosagem , Erupção por Droga/tratamento farmacológico , Isotretinoína/administração & dosagem , Esquizofrenia Paranoide/tratamento farmacológico , Pele/efeitos dos fármacos , Erupções Acneiformes/induzido quimicamente , Erupções Acneiformes/diagnóstico , Administração Oral , Adulto , Erupção por Droga/diagnóstico , Erupção por Droga/etiologia , Humanos , Masculino , Indução de Remissão , Esquizofrenia Paranoide/diagnóstico , Esquizofrenia Paranoide/psicologia , Pele/patologia , Resultado do Tratamento
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