Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.923
Filtrar
1.
Einstein (Sao Paulo) ; 18: eAO5075, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32321080

RESUMO

OBJECTIVE: To evaluate the nutritional risk factors in patients eligible for hematopoietic stem cell transplantation. METHODS: A cross-sectional, descriptive study conducted with patients recruited from an hematology outpatient clinic. Study variables included demographic and clinical data, patient-generated global subjective assessment findings, anthropometric indicators, food intake and oxidative stress levels. The level of significance was set at 5% (p<0.05). RESULTS: The sample comprised 72 patients, mean age of 48.93 years (14.5%). Multiple myeloma was the most prevalent condition (51.4%) in this sample. Most patients (55.6%) were overweight according to body mass index and at risk of cardiovascular disease according to waist circumference, conicity index and percentage of body fat. Sarcopenia was associated with risk of cardiovascular disease, hip-to-waist ratio (p=0.021), muscle strength depletion (p<0.001), food intake (p=0.023), reduced functional capacity (p=0.048), self-reported well-nourished status; p=0.044) and inadequate vitamin B6 (p=0.022) and manganese (p=0.026) intake. Elevated oxidative stress, detected in 33.3% of patients in this sample, was not associated with sarcopenia. CONCLUSION: Most patients in this sample were overweight and sarcopenic. Lean mass depletion was associated with risk of cardiovascular disease, reduced muscle strength, food intake changes, reduced functional capacity, self-reported well-nourished status and inadequate intake of vitamin B6 and manganese, but not with oxidative stress.


Assuntos
Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Avaliação Nutricional , Medição de Risco/métodos , Adulto , Antropometria , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/fisiopatologia , Estudos Transversais , Ingestão de Alimentos/fisiologia , Ingestão de Energia/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/fisiopatologia , Mieloma Múltiplo/cirurgia , Força Muscular/fisiologia , Estado Nutricional/fisiologia , Sobrepeso/complicações , Sobrepeso/fisiopatologia , Estresse Oxidativo/fisiologia , Fatores de Risco , Sarcopenia/complicações , Sarcopenia/fisiopatologia
2.
Medicine (Baltimore) ; 99(17): e19879, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32332658

RESUMO

BACKGROUND: Epidemiological studies have reported an inconsistent relationship between dietary inflammatory index (DII) and upper aerodigestive tract (UADT) cancer risk. However, no systematic review or meta-analysis has been reported up to now. To quantify the association between DII and UADT cancer risk, we performed this meta-analysis. METHODS: The PubMed, EMBASE, Web of Science and Cochrane Library database were searched for relevant studies from inception December 2018. All case-control studies investigating the association between DII and UADT cancer risk were selected. RESULTS: A total of 9 case-control studies were identified, involving 13,714 participants. The adjusted pooled OR of UADT cancer for the highest (the most pro-inflammatory diet) vs lowest (the most anti-inflammatory diet) DII categories were 2.27 (95% CI: 1.89-2.73). Subgroup analysis showed that individuals with the highest category of DII score were independently associated with esophagus cancer (OR = 2.53, 95% CI: 1.74-3.68), oral cavity cancer (OR = 2.23, 95% CI: 1.73-2.86), pharyngeal cancer (OR = 2.02, 95% CI: 1.54-2.64), and laryngeal cancer (OR = 2.05, 95% CI: 0.85-4.93). CONCLUSION: This meta-analysis suggested that the most pro-inflammatory diets (the highest DII scores) are associated with increased UADT cancer risk. However, the association between DII and laryngeal cancer risk need to be further investigated.


Assuntos
Neoplasias de Cabeça e Pescoço/fisiopatologia , Inflamação/dietoterapia , Estado Nutricional/imunologia , Estado Nutricional/fisiologia , Estudos de Casos e Controles , Neoplasias de Cabeça e Pescoço/dietoterapia , Neoplasias de Cabeça e Pescoço/etiologia , Humanos , Razão de Chances , Fatores de Risco
3.
Rev Col Bras Cir ; 46(6): e20192382, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32022115

RESUMO

OBJECTIVE: to evaluate the association of food consumption with nutritional status, physical activity and sociodemographic factors in the bariatric surgery period preoperative. METHODS: we conducted a cross-sectional study from 2018 to 2019, with patients admitted for bariatric surgery at the Oswaldo Cruz University Hospital, Federal University of Pernambuco. We collected data sociodemographic and nutritional data such as body mass index (BMI), waist circumference, highest weight and pre-surgical weight. We evaluated food consumption with the food frequency questionnaire based on the food pyramid adapted for bariatric patients and physical activity. RESULTS: the study involved 60 patients, 78.3% were female, mean age was 38.8±9.6 years, 53.3% were married, and 70% had more than 12 years of education. As for physical activity, 31.7% were sedentary. Regarding nutritional status, the mean BMI was 47.3±6.96kg/m2. Preoperative weight, highest weight reached before surgery and waist circumference were higher in males (p<0.05). There was an association between physical activity and food intake, and sedentary individuals consumed more carbohydrates (p=0.041). On the other hand, sociodemographic data and nutritional status were not associated with food consumption. CONCLUSION: the level of physical activity showed significant association only with carbohydrate consumption.


Assuntos
Cirurgia Bariátrica , Exercício Físico/fisiologia , Estado Nutricional/fisiologia , Obesidade/cirurgia , Sobrepeso/cirurgia , Adulto , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pré-Operatórios , Fatores Socioeconômicos , Inquéritos e Questionários
4.
PLoS One ; 15(1): e0216516, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31978089

RESUMO

Childhood obesity is an undeniable reality that has rapidly increased in many countries. Obesity at an early age not only increases the risks of chronic diseases but also produces a problem for the whole healthcare system. One way to alleviate this problem is to provide each patient with an appropriate menu that is defined by a mathematical model. Existing mathematical models only partially address the objective and constraints of childhood obesity; therefore, the solutions provided are insufficient for health specialists to prepare nutritional menus for individual patients. This manuscript proposes a multiobjective mathematical programming model to aid in healthy nutritional menu planning that may prevent childhood obesity. This model provides a plan for combinations and amounts of food across different schedules and daily meals. This approach minimizes the major risk factors of childhood obesity (i.e., glycemic load and cholesterol intake). In addition, this approach considers the minimization of nutritional mismatch and total cost. The model is solved using a deterministic method and two metaheuristic methods. Test instances associated with children aged 4-18 years were created with the support of health professionals to complete this numerical study. The quality of the solutions generated using the three methods was similar, but the metaheuristic methods provided solutions in a shorter computational time. These results are submitted to statistical hypothesis tests to be validated. The numerical results indicate proper guidelines for personalized plans for individual children.


Assuntos
Dieta , Ácidos Graxos/metabolismo , Estado Nutricional/fisiologia , Obesidade Pediátrica/dietoterapia , Adolescente , Animais , Criança , Pré-Escolar , Ingestão de Energia/fisiologia , Feminino , Humanos , Masculino , Refeições , Planejamento de Cardápio/normas , Leite/metabolismo , Política Nutricional , Obesidade Pediátrica/epidemiologia , Fatores de Risco
5.
PLoS One ; 15(1): e0218960, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31995570

RESUMO

South Asia has >50% of the global burden of low birth weight (LBW). The objective was to determine the extent to which maternal nutrition interventions commenced before conception or in the 1st trimester improved fetal growth in this region. This was a secondary analysis of combined newborn anthropometric data for the South Asian sites (India and Pakistan) in the Women First Preconception Maternal Nutrition Trial. Participants were 972 newborn of mothers who were poor, rural, unselected on basis of nutritional status, and had been randomized to receive a daily lipid-based micronutrient supplement commencing ≥3 months prior to conception (Arm 1), in the 1st trimester (Arm 2), or not at all (Arm 3). An additional protein-energy supplement was provided if BMI <20 kg/m2 or gestational weight gain was less than guidelines. Gestational age was established in the 1st trimester and newborn anthropometry obtained <48-hours post-delivery. Mean differences at birth between Arm 1 vs. 3 were length +5.3mm and weight +89g. Effect sizes (ES) and relative risks (RR) with 95% CI for Arm 1 vs. 3 were: length-for-age Z-score (LAZ) +0.29 (0.11-0.46, p = 0.0011); weight-for-age Z-score (WAZ) +0.22 (0.07-0.37, p = 0.0043); weight-to-length-ratio-for-age Z-score (WLRAZ) +0.27 (0.06-0.48, p = 0.0133); LAZ<-2, 0.56 (0.38-0.82, p = 0.0032); WAZ <-2, 0.68 (0.53-0.88, p = 0.0028); WLRAZ <-2, 0.76 (0.64-0.89, p = 0.0011); small-for-gestational-age (SGA), 0.74 (0.66-0.83, p<0.0001); low birth weight 0.81 (0.66-1.00, p = 0.0461). For Arm 2 vs. 3, LAZ, 0.21 (0.04-0.38); WAZ <-2, 0.70 (0.53-0.92); and SGA, 0.88 (0.79-0.97) were only marginally different. ES or RR did not differ for preterm birth for either Arm 1 vs. 3 or 2 vs. 3. In conclusion, point estimates for both continuous and binary anthropometric outcomes were consistently more favorable when maternal nutrition supplements were commenced ≥3 months prior to conception indicating benefits to fetal growth of improving women's nutrition in this population.


Assuntos
Gorduras na Dieta/administração & dosagem , Suplementos Nutricionais , Recém-Nascido Pequeno para a Idade Gestacional/crescimento & desenvolvimento , Adulto , Antropometria , Feminino , Feto , Idade Gestacional , Humanos , Índia , Recém-Nascido , Estado Nutricional/fisiologia , Paquistão , Pobreza , Cuidado Pré-Concepcional/métodos , Gravidez , Primeiro Trimestre da Gravidez , População Rural
6.
Nat Rev Mol Cell Biol ; 21(4): 183-203, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31937935

RESUMO

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway's central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.


Assuntos
Serina-Treonina Quinases TOR/genética , Serina-Treonina Quinases TOR/metabolismo , Envelhecimento/metabolismo , Animais , Autofagia/fisiologia , Humanos , Doenças Metabólicas/metabolismo , Neoplasias/metabolismo , Estado Nutricional/fisiologia , Biossíntese de Proteínas/fisiologia , Transdução de Sinais/fisiologia
7.
PLoS One ; 15(1): e0227873, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31935272

RESUMO

BACKGROUND: Adequate nutrition is essential during the lactation period for better maternal and child health outcomes. Although food insecurity and dietary monotony (defined as less diverse diet), two important determinants of undernutrition, are endemic in the rural mountains of Nepal, insufficiently examined and assessed for risk factors in mothers during lactation, a life stage of high nutritional demand. This study aimed to assess the status and factors associated with food insecurity and dietary diversity among lactating mothers residing in the mountains of Nepal. METHODS: A community-based cross-sectional study was conducted in an urban municipality in the mountainous Bajhang District of far-western Nepal. The sampling frame and strategy led to 417 randomly selected lactating mothers. Household Food Insecurity Access Scale (HFIAS) and the tool "Minimum Dietary Diversity for Women" developed by the Food and Agriculture Organization were used to measure food insecurity and dietary diversity, respectively. Additional information on socio-demographics and risk factors were collected. Multivariable logistics regression assessed correlates of study outcomes. RESULTS: Overall, 54% of the households were food insecure, and over half (53%) of the mothers had low dietary diversity. Food insecurity status (mild food insecurity AOR = 10.12, 95% CI = 4.21-24.34; moderate food insecurity AOR = 8.17, 95% CI = 3.24-20.59, and severe food insecurity AOR = 10.56, 95% CI = 3.92-28.43) were associated with higher odds of dietary monotony. Likewise, participants with lower dietary diversity were 8.5 times more likely to be food insecure than those with higher dietary diversity (AOR = 8.48, 95% CI = 3.76-19.14). The monthly income of the family was positively associated with food insecurity. Participants' (AOR = 3.92 95%CI = 1.76-8.71) or spouses' (AOR = 2.90, 95% CI = 1.07-7.85) unemployment was associated with higher odds of being food insecure. Likewise, owning a cultivable land (AOR = 0.49, 95% CI = 0.28-0.84) and participant's unemployment status (AOR = 5.92, 95% CI = 3.02-11.63), were significantly associated with increased odds of dietary monotony. CONCLUSION: The observed food insecurity and poor dietary diversity among lactating mothers, the correlates associated with these outcomes, may help local stakeholders to identify local health needs and subgroups for targeted interventions. Socioeconomically disadvantaged mothers should be specifically targeted for relevant programs and policies.


Assuntos
Comportamento Alimentar/fisiologia , Abastecimento de Alimentos , Alimentos , Lactação/fisiologia , Adulto , Idoso , Dieta , Características da Família , Feminino , Humanos , Renda , Lactação/metabolismo , Pessoa de Meia-Idade , Mães , Nepal/epidemiologia , Estado Nutricional/fisiologia , Gravidez , Fatores de Risco , População Rural , Fatores Socioeconômicos , Adulto Jovem
8.
Curr Probl Cardiol ; 45(1): 100391, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30318107

RESUMO

The metabolic sources of energy for myocardial contractility include mainly free fatty acids (FFA) for 95%, and in lesser amounts for 5% from glucose and minimal contributions from other substrates such lactate, ketones, and amino acids. However, myocardial efficiency is influenced by metabolic condition, overload, and ischemia. During cardiac stress, cardiomyocytes increase glucose oxidation and reduce FFA oxidation. In patients with ischemic coronary disease and heart failure, the low oxygen availability limits myocardial reliance on FFA and glucose utilization must increase. Although glucose uptake is fundamental to cardiomyocyte function, an excessive intracellular glucose level is detrimental. Insulin plays a fundamental role in maintaining myocardial efficiency and in reducing glycemia and inflammation; this is particularly evident in obese and type-2 diabetic patients. An excess of F availability increase fat deposition within cardiomyocytes and reduces glucose oxidation. In patients with high body mass index, a restricted diet or starvation have positive effects on cardiac metabolism and function while, in patients with low body mass index, restrictive diets, or starvation have a deleterious effect. Thus, weight loss in obese patients has positive impacts on ventricular mass and function, whereas, in underweight heart failure patients, such weight reduction adds to the risk of heart damage, predisposing to cachexia. Nutrition plays an essential role in the evolution of cardiovascular disease and should be taken into account. An energy-restricted diet improves myocardial efficiency but can represent a potential risk of heart damage, particularly in patients affected by cardiovascular disease. Micronutrient integration has a marginal effect on cardiovascular efficiency.


Assuntos
Doenças Cardiovasculares/metabolismo , Metabolismo Energético , Contração Miocárdica/fisiologia , Miocárdio/metabolismo , Estado Nutricional/fisiologia , Apoio Nutricional/métodos , Aminoácidos/metabolismo , Doenças Cardiovasculares/fisiopatologia , Ácidos Graxos não Esterificados/metabolismo , Glucose/metabolismo , Humanos , Oxirredução
9.
Einstein (Sao Paulo) ; 18: eAO4039, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31851223

RESUMO

OBJECTIVE: To evaluate the oxidative profile, nutritional status and food intake (caloric value; macronutrients; vitamins A, E and C; and zinc), and to correlate oxidative stress with nutritional status in patients who were candidates for liver transplant. METHODS: This is a cross-sectional, analytical, and descriptive study with 51 candidates for liver transplant. Sociodemographic and clinical data, anthropometric parameters, food consumption, and a 10mL blood sample were collected from each patient. Oxidative stress was analyzed by the thiobarbituric acid method. The consumption of macronutrients, caloric value and micronutrients (zinc, vitamins A, E and C) were qualitatively analyzed, and zinc was also quantitatively analyzed. RESULTS: The mean age was 49.17±8.17 years. The highest percentage of malnutrition was according to arm muscle circumference (56.86%), followed by arm circumference (52.94%), triceps skin fold (50.98%), and body mass index (1.96%). The mean malondialdehyde level was 14.80±8.72µM/L, presenting a negative correlation with the body mass index for patients with liver cirrhosis according to IMC-Campillo values (p=0.001; r=-0.430). Low energy, carbohydrate, protein, vitamin A and E consumption were observed in more than 50% of subjects. CONCLUSION: This study showed an association of nutritional status through body mass index for patients with liver cirrhosis according to IMC-Campillo, with oxidative stress in patients with liver cirrhosis on a liver transplant waiting list.


Assuntos
Doença Hepática Terminal/metabolismo , Transplante de Fígado/estatística & dados numéricos , Estado Nutricional/fisiologia , Estresse Oxidativo/fisiologia , Transplantados/estatística & dados numéricos , Adulto , Antropometria , Estudos Transversais , Escolaridade , Doença Hepática Terminal/cirurgia , Ingestão de Energia , Comportamento Alimentar/fisiologia , Feminino , Humanos , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Avaliação Nutricional , Valores de Referência , Estatísticas não Paramétricas
10.
Dtsch Med Wochenschr ; 145(1): e1-e9, 2020 01.
Artigo em Alemão | MEDLINE | ID: mdl-31858492

RESUMO

BACKGROUND: The nutritional status of patients with tumor diseases in German out-patient clinics is largely unknown. This cross-sectional survey on patients with tumor diseases aimed to assess the prevalence of the risk of malnutrition in this group. METHODS: In out-patient clinics of oncologists, patients with a diagnosed cancer disease were consecutively interrogated between June 2017 and May 2018 using a standardized questionnaire. In addition to questions on the health status and dietary habits, the validated screening questionnaires Malnutrition Universal Screening Tool (MUST) and the Nutrition Risk Screening Tool-2002 (NRS-2002) were used to assess the risk of malnutrition of these patients (primary endpoint). A descriptive statistical analysis was performed. RESULTS: In total, data from 765 patients with a diagnosed tumor (60.9 % female) were analyzed. The participants had a mean age of 63.1 ±â€Š13.1 years and a mean body mass index (BMI) of 25.2 ±â€Š5.1 kg/m². Using the MUST questionnaire 15.4 % of participants had a moderately increased risk and 19.5 % a high risk of malnutrition. Of those, patients with tumors of the gastrointestinal tract showed the highest rate of malnutrition risk (46.6 %). The criteria for a nutrition risk based on the NRS-2002 questionnaire (score ≥ 3) were fulfilled by 29.1 % of the patients. Less than one third of the patients reported to have received dietary counselling after cancer diagnosis (29.9 %). CONCLUSION: Every third patient with a diagnosed tumor disease in out-patient care exhibits an increased risk of malnutrition. The results of this survey clearly indicate the need for a systematic screening for malnutrition and an evidence-based nutrition management of tumor patients under ambulatory care.


Assuntos
Assistência Ambulatorial , Desnutrição , Neoplasias , Idoso , Assistência Ambulatorial/estatística & dados numéricos , Estudos Transversais , Feminino , Humanos , Masculino , Desnutrição/epidemiologia , Desnutrição/etiologia , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/epidemiologia , Neoplasias/terapia , Estado Nutricional/fisiologia , Prevalência , Inquéritos e Questionários
11.
Support Care Cancer ; 28(1): 341-349, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31044309

RESUMO

PURPOSE: This study analysed nutritional parameters (baseline body mass index (BMI), weight changes and enteral nutrition (EN) use, and their association with hospital admissions during radiotherapy in patients with head and neck cancer (HNC)). METHODS: A retrospective review of patients diagnosed with HNC and treated with radiotherapy between October 2012 and April 2014 was conducted. Data on each subject's diagnosis, age, sex, chemotherapy, previous surgery, EN use, weight changes, and BMI were examined for their association with hospital admissions during treatment. RESULTS: Eighty-three patients were included, mean age (±standard deviation) = 61 (± 11 years). Thirty-four percent had self-reported weight loss at diagnosis, and mean BMI was 26.2 ± 5.3 kg/m2. Mean weight change during treatment was - 5.1 ± 6.2%. Ten patients used EN, with mean weight stabilisation during EN use (0.3 ± 5.1%). Higher presenting BMI, younger age, and definitive radiotherapy ± chemotherapy predicted greater weight loss (p < 0.05). Critical weight loss ≥ 5% was associated with a higher number of hospital admissions for nutrition reasons (n = 10) (p = 0.011) compared with those without critical weight loss (n = 2). EN use was associated with a higher number of nutrition-related admissions; however, it did not predict length of stay among those admitted. CONCLUSION: Critical weight loss during radiotherapy was associated with unplanned nutrition-related hospital admissions. Higher BMI was associated with greater weight loss during radiotherapy, whilst EN use assisted in weight preservation. Further research around patient selection for nutritional interventions aimed at preventing critical weight loss and unplanned hospital admissions is needed.


Assuntos
Nutrição Enteral/estatística & dados numéricos , Neoplasias de Cabeça e Pescoço/epidemiologia , Neoplasias de Cabeça e Pescoço/terapia , Estado Nutricional/fisiologia , Admissão do Paciente/estatística & dados numéricos , Adulto , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Austrália/epidemiologia , Índice de Massa Corporal , Caquexia/epidemiologia , Caquexia/etiologia , Caquexia/terapia , Nutrição Enteral/efeitos adversos , Feminino , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Radioterapia/efeitos adversos , Radioterapia/métodos , Radioterapia/estatística & dados numéricos , Estudos Retrospectivos , Perda de Peso/fisiologia
12.
Support Care Cancer ; 28(1): 373-380, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31049672

RESUMO

BACKGROUND/OBJECTIVES: The assessment of nutritional status and the quality of life in patients with gastric cancer has become one of the important goals of current clinical treatment. The purpose of this study was to assess the nutritional status in hospitalized gastric cancer patients by using patient-generated subjective global assessment (PG-SGA) and to analyze the influence of nutritional status on the patients' quality of life (QOL). METHODS: We reviewed the pathological diagnosis of gastric cancer for 2322 hospitalized patients using PG-SGA to assess their nutritional status and collected data on clinical symptoms, the anthropometric parameters (height, weight, body mass index (BMI), mid-arm circumference (MAC), triceps skin-fold thickness (TSF), and hand-grip strength (HGS). We also collected laboratory data (prealbumin, albumin, hemoglobin) within 48 h after the patient was admitted to the hospital. The 30-item European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) was used for QOL assessment in all patients. RESULTS: By using PG-SGA, we found 80.4% of the patients were malnourished (score ≥ 4) and 45.1% of the patients required urgent nutritional support (score ≥ 9). In univariate analysis, old age (> 65 years, p < 0.001), female (p = 0.007), residence in a village (p = 0.004), a lower level of education (p < 0.001), and self-paying (p < 0.001) were indicated as risk factors of patients with gastric cancer to be suffering from severe malnutrition. There was a negative correlation between PG-SGA and various nutritional parameters (p < 0.05). The quality of life was significantly different in gastric cancer patients with different nutritional status (p < 0.01). CONCLUSION: Malnutrition of hospitalized patients with gastric cancer in China is common and seriously affects the patients' quality of life. The nutritional status should be evaluated in a timely manner and reasonable nutritional intervention should be provided as soon as possible. The PG-SGA was fit for using as a clinical nutrition assessment method, being worthy of clinical application.


Assuntos
Hospitalização/estatística & dados numéricos , Estado Nutricional/fisiologia , Qualidade de Vida , Neoplasias Gástricas/epidemiologia , Neoplasias Gástricas/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Índice de Massa Corporal , Peso Corporal/fisiologia , China/epidemiologia , Estudos Transversais , Feminino , Força da Mão/fisiologia , Humanos , Masculino , Desnutrição/epidemiologia , Desnutrição/etiologia , Desnutrição/terapia , Pessoa de Meia-Idade , Avaliação Nutricional , Estudos Retrospectivos , Fatores de Risco , Neoplasias Gástricas/complicações , Inquéritos e Questionários
13.
Vet Parasitol ; 276: 108973, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31785456

RESUMO

The objective of this study was to measure the effect of the nutritional status of Creole goat kids on the host responses and the nematode population established after an experimental H. contortus infection. Fifty six kids were fed with 4 diets corresponding to 2 nutritional statuses: the low nutritional status (HAY, hay ad libitum and HB, Hay ad libitum + banana) and the high nutritional status (HS, hay ad libitum + soya meal and HSB, hay ad libitum + banana + soya meal). For each diet, 8 kids were experimentally infected with 10,000 H. contortus infective larvae (L3) and 6 kids were kept as non-infected controls. From the day of infection until 6 weeks post-infection, samples were collected to measure individual intake, total tract digestibility, parasitological and hematological parameters. The dry matter intake (DMI), the average daily gain (ADG), the crude protein (CP) and the digestible CP intake were higher in goats fed the HS and HSB diets, but no statistically significant interaction between the nutritional status and the infection was observed. The packed cell volume (PCV), the red blood cell counts (RBC) and the mean corpuscular volume (MCV) were higher with the HS and the HSB diets. In kids with the high nutritional status the nematode burden and pathophysiological impact of the infection were significantly lower but not the FEC. In conclusion, this reduced establishment rate was associated with an increased production of eggs by the female parasites and suggested a phenomenon of density-dependent prolificacy of H. contortus probably inherent to the fitness of the parasite population.


Assuntos
Doenças das Cabras/parasitologia , Hemoncose/veterinária , Haemonchus/crescimento & desenvolvimento , Estado Nutricional/fisiologia , Anemia/prevenção & controle , Anemia/veterinária , Ração Animal/análise , Ração Animal/normas , Animais , Dieta/veterinária , Digestão , Ingestão de Alimentos , Eosinófilos/citologia , Fezes/química , Fezes/parasitologia , Feminino , Doenças das Cabras/fisiopatologia , Doenças das Cabras/prevenção & controle , Cabras , Hemoncose/parasitologia , Hemoncose/fisiopatologia , Contagem de Leucócitos/veterinária , Masculino , Contagem de Ovos de Parasitas/veterinária , Pepsinogênio A/sangue
14.
Clinics (Sao Paulo) ; 74: e798, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644665

RESUMO

OBJECTIVE: To describe the nutritional profile of newborns with microcephaly and factors associated with worse outcomes during the first 14 days of life. METHODS: This investigation is a longitudinal, descriptive study carried out in 21 full-term neonates exposed vertically to the Zika virus and hospitalized in a neonatal intensive care unit from February to September 2016. Patients receiving parenteral nutrition were excluded. Data analysis was performed using a generalized estimating equation model and Student's t-test to evaluate the association between worsening weight-for-age z-scores and independent clinical, sociodemographic and nutritional variables during hospitalization, with p<0.05 indicating significance. RESULTS: During hospitalization, there was a decrease in the mean values of the weight-for-age z-scores. The factors associated with worse nutritional outcomes were symptomatic exposure to the Zika virus, low maternal schooling, absence of maternal income and consumption of infant formula (p<0.05). Calcification and severe microcephaly were also associated with poor nutritional outcomes. Energy and macronutrient consumption remained below the recommendations and had an upward trend during hospitalization. CONCLUSION: The presence of cerebral calcification, the severity of microcephaly and symptomatic maternal exposure to Zika virus affected the nutritional status of newborns. In terms of nutritional factors, human milk intake had a positive impact, reducing weight loss in the first days of life. Other known factors, such as income and maternal schooling, were still associated with a poor nutritional status.


Assuntos
Microcefalia/fisiopatologia , Estado Nutricional/fisiologia , Infecção por Zika virus/complicações , Adolescente , Adulto , Feminino , Humanos , Recém-Nascido , Estudos Longitudinais , Masculino , Microcefalia/virologia , Fatores de Risco , Índice de Gravidade de Doença , Fatores Socioeconômicos , Adulto Jovem
15.
Obes Facts ; 12(5): 554-563, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31639803

RESUMO

INTRODUCTION: A rational way of nourishment, combined with adequate physical activity, are the basic components of maintaining proper body condition. OBJECTIVE: The aim of the study was to evaluate nutritional status among children and adolescents with different levels of physical activity. METHODS: The study group consisted of 1,013 students of both genders aged between 7 and 18 years attending elementary and post-primary schools (general and sports profile) in Siemianowice Slaskie. RESULTS: The crude body mass index (BMI) values ranged from 12.78 to 35.3. Body mass within the limits of arbitrary standard referred to 70% of the examined group, overweight or obesity was found in over 25%. Percentage of body fat (FATP) values ranged from 5.7 to 45.2%. CONCLUSIONS: A significant number of children and adolescents were overweight or obese based on BMI categories and FATP values. Overweight and obesity were most common among younger children, particularly boys. Higher torso FATP levels were more common among sports-oriented class students. BMI is not a good tool for the determination of the nutritional status of children and adolescents, while the bioelectric impedance method enables one to conduct a precise analysis of adipose tissue content and location. Sports-oriented elementary school students from the study group were characterized by higher FATP values.


Assuntos
Exercício Físico/fisiologia , Avaliação Nutricional , Estado Nutricional/fisiologia , Obesidade Pediátrica , Tecido Adiposo/metabolismo , Adolescente , Composição Corporal/fisiologia , Índice de Massa Corporal , Criança , Feminino , Humanos , Masculino , Sobrepeso/diagnóstico , Sobrepeso/epidemiologia , Sobrepeso/metabolismo , Sobrepeso/fisiopatologia , Obesidade Pediátrica/diagnóstico , Obesidade Pediátrica/epidemiologia , Obesidade Pediátrica/metabolismo , Obesidade Pediátrica/fisiopatologia , Polônia/epidemiologia , Instituições Acadêmicas/estatística & dados numéricos , Esportes/estatística & dados numéricos , Estudantes/estatística & dados numéricos
16.
Biomed Res Int ; 2019: 5897478, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31531358

RESUMO

Background: Smoking is the second leading cause of death. Limited studies are available about smoking and overall diet quality. The current study was aimed at finding an association of s-KAP (smoking-related knowledge, attitude, and practices) with nutritional status and diet quality. Methodology: The current study was a cross-sectional community-based study conducted in Jurong city, China. Validated questionnaires were used for the collection of data regarding s-KAP and dietary intake. Correlation and multivariate linear regression analysis were used for the association of s-KAP scores with diet quality scores and nutritional status. Results: The total numbers of participants were 7998 with a mean age of 59.3±11.4 years, including 38.5% males and 41.5% females. s-KAP scores were categorized into two groups, i.e., High s-KAP group and low s-KAP group. The High s-KAP group had significantly higher (P<0.05) diet scores and BMI but lower (P<0.05) WC (waist circumference) and WHR (waist to hip ratio) than the Low s-KAP group. Independent positive association (P<0.05) of s-KAP scores with diet scores was observed after the adjustment for age, gender, physical activity, alcohol consumptions, monthly income, and anthropometric measures (BMI, WC, and WHR). Similarly, smoking was positively associated (P<0.05) with diet scores after adjustment for covariates. Conclusion: In conclusion, the higher s-KAP scores indicated more knowledge regarding the harmful consequences of the smoking outcomes, positive attitude, less smoking practices, and having a good plan to quit smoking. Individuals with high s-KAP scores had good diet quality and lower adiposity measures. Furthermore, s-KAP scores and smoking status were having an independent positive association with diet scores.


Assuntos
Dieta/efeitos adversos , Dieta/estatística & dados numéricos , Estado Nutricional/fisiologia , Fumar/efeitos adversos , Adiposidade/fisiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Índice de Massa Corporal , China , Estudos Transversais , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Renda/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Circunferência da Cintura/fisiologia , Relação Cintura-Quadril/métodos , Relação Cintura-Quadril/estatística & dados numéricos , Adulto Jovem
17.
Biosci Trends ; 13(4): 358-360, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31527332

RESUMO

A growing number of studies show that breastfeeding is the best source of nutrition for infants and young children and one of the most effective measures to ensure the healthy growth and development of children. However, a study from the China Development Research Fund found that the rate of exclusive breastfeeding among Chinese infants within six months of birth is only 29%, a rate that is lower than that in other countries and regions of the world. Other data provided by the World Bank shows that the rate of exclusive breastfeeding in China declined from 1998 to 2013 and that it increased slightly by 2018, but it was still lower than the global average. Compared to other Asian countries, the exclusive breastfeeding rate in China is also low. Establishing a sound breastfeeding support system and creating a breastfeeding environment with full support for mothers of infants is a way to effectively improve the state of breastfeeding in China, to ensure the healthy growth of children, and to achieve the goals of Healthy China 2030.


Assuntos
Aleitamento Materno/estatística & dados numéricos , Desenvolvimento Infantil/fisiologia , Saúde da Criança , Promoção da Saúde/organização & administração , China , Comparação Transcultural , Feminino , Humanos , Lactente , Estado Nutricional/fisiologia
18.
Rocz Panstw Zakl Hig ; 70(3): 243-251, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31515983

RESUMO

Background: The somatic features of the athletes' bodies partially determine their sporting level and are conditioned to a large extent by the state of nutrition. Objective: The aim of this paper is to present nutritional status and its correlation with the somatic determinants of training athletes and physical education students. Material and methods: This study involved 12 weightlifting players (subgroup-WL), 15 soccer players (subgroup-SP), 12 table tennis players (subgroup-TT) and 12 female students of physical education (subgroup-C). In all subjects, the age and somatic variables were recorded and the daily intake of energy, water, proteins, fats and carbohydrates was determined by 24-h dietary recalls. Results: Although the analysis of variance did not show significant differences in somatic variables and nutrition data, post hoc analysis showed significant differences between some subgroups in terms of age, BMI, fat content (BF), fat-free mass (FFM) and the amount of water, protein and carbohydrates consumed during the day. It was also shown that somatic variables correlated with relatively expressed amounts of energy, proteins and carbohydrates consumed in individual subgroups, as well as in the whole group formed from all subgroups of studied women. In addition, there were significant correlations between somatic variables and the total amount of water consumed in the whole group and the total amount of protein consumed in subgroup C (p<0.05), as well as the total amount of fat consumed in subgroup WL. Conclusions: In summary, it was found that the examined women used an abnormal hypoenergetic diet with too low carbohydrate content in which were more useful relative than absolute amounts of consumed proteins, fats and carbohydrates. In this unfavorable situation, dietary education of the respondents seems to be necessary.


Assuntos
Atletas , Composição Corporal/fisiologia , Índice de Massa Corporal , Estado Nutricional/fisiologia , Esportes/fisiologia , Adulto , Feminino , Humanos , Polônia , Adulto Jovem
19.
Rev Assoc Med Bras (1992) ; 65(7): 952-958, 2019 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-31389504

RESUMO

PURPOSE: In this prospective observational study, we aimed to investigate the role of the maximum compressed (MC) and uncompressed (UC) thickness of the quadriceps femoris muscle (QFMT) measured by ultrasonography (USG) in the detection of nutritional risk in intensive care patients (ICPs) with different volume status. METHODS: 55 patients were included. Right, left, and total ucQFMT and mcQFMT measurements were obtained by a standard USG device within the first 48 hours after ICU admission. Clinical examination and the USG device were used to determine the volume status of the patients. SOFA, APACHE II, modified NUTRIC scores, and demographic data were collected. RESULTS: There was a significant difference between the nutritional risk of patients in terms of left, right, and total mcQFMT measurements (p=0.025, p=0.039; p=0.028, respectively), mechanical ventilation requirement (p=0.014), presence of infection (p=0.019), and sepsis (p=0.006). There was no significant difference between different volume statuses in terms of mcQFMT measurements. In the multi-variance analysis, mcQFMT measurements were found to be independently associated with high nutritional risk (p=0.019, Exp(B)=0.256, 95%CI=0.082-0.800 for modified NUTRIC score ≥ 5), and higher nutritional risk (p=0.009, Exp(B)=0.144, 95%CI=0.033-0.620 for modified NUTRIC score ≥ 6). a Total mcQFMT value below 1.36 cm was a predictor for higher nutritional risk with 79% sensitivity and 70% specificity (AUC=0.749, p=0.002, likelihood ratio=2.04). CONCLUSION: Ultrasonographic measurement of total mcQFMT can be used as a novel nutritional risk assessment parameter in medical ICPs with different volume statuses. Thus, patients who could benefit from aggressive nutritional therapy can be easily identified in these patient groups.


Assuntos
Estado Nutricional/fisiologia , Músculo Quadríceps/diagnóstico por imagem , Músculo Quadríceps/patologia , Ultrassonografia/métodos , APACHE , Idoso , Idoso de 80 Anos ou mais , Estado Terminal , Feminino , Humanos , Unidades de Terapia Intensiva , Tempo de Internação , Modelos Logísticos , Masculino , Desnutrição/diagnóstico por imagem , Desnutrição/patologia , Desnutrição/fisiopatologia , Pessoa de Meia-Idade , Avaliação Nutricional , Terapia Nutricional/métodos , Estudos Prospectivos , Músculo Quadríceps/fisiopatologia , Valores de Referência , Respiração Artificial/efeitos adversos , Medição de Risco , Sensibilidade e Especificidade
20.
Nutrients ; 11(8)2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31398886

RESUMO

Cellular pathways such as inflammation or oxidative stress are the cause and triggers of disease-related malnutrition (DRM), but the influence of these markers on endoplasmic reticulum (ER) stress is unknown. The objective of this study was to analyze the relationship between mitochondrial function and ER stress parameters in a DRM population. The study population was composed of 82 outpatient subjects, of whom 45 were diagnosed with DRM and 37 were confirmed to be normonourished according to the American Society for Parenteral and Enteral Nutrition ASPEN criteria. We evaluated anthropometrical and biochemical parameters, pro-inflammatory cytokines in serum. Oxidative and ER stress markers were analyzed in leukocytes. DRM patients showed significant reductions in albumin and transferrin concerning the normonourished group, and also displayed higher levels of hsCRP, IL6, and TNFα, and the soluble adhesion molecules VCAM-1 and ICAM-1. Besides, oxygen consumption and mitochondrial membrane potential were reduced and Radical Oxygen Species ROS production was enhanced in DRM patients. In the case of ER markers, protein and mRNA expression revealed that CHOP, ATF6, and the P-eIF2α signal were enhanced in malnourished patients compared to control subjects. Correlation studies supported a relationship between weight loss and increased inflammation, mitochondrial dysfunction, and compromised function of the ER. Our results demonstrate that ER stress signaling pathways are influenced by inflammation and mitochondrial function in the leukocytes of a DRM population.


Assuntos
Estresse do Retículo Endoplasmático/fisiologia , Retículo Endoplasmático/fisiologia , Leucócitos/fisiologia , Desnutrição/fisiopatologia , Estresse Oxidativo/fisiologia , Adulto , Idoso , Antropometria , Citocinas/sangue , Feminino , Humanos , Masculino , Desnutrição/sangue , Desnutrição/etiologia , Pessoa de Meia-Idade , Estado Nutricional/fisiologia , Pacientes Ambulatoriais
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA