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1.
PLoS One ; 16(10): e0246725, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34699530

RESUMO

BACKGROUND: Stunting, an indicator of restricted linear growth, has become a primary measure of childhood undernutrition due to its persistent high prevalence globally, and importance for health and development. Although the etiology is recognized as complex, most analyses have focused on social and biomedical determinants, with limited attention on psychological factors affecting care and nurturing in the home. We assessed whether the psychological distress of parents is related to child linear growth and stunting, and documented the associated risk factors, and examined the relationship between parental distress and behavioral and other risk factors for stunting. METHODS: We used data from the Indonesia National Health Survey 2013, including 46,315 children 6-59 months of age. Multivariate linear, logistic, and multilevel multinomial logistic regression, using survey weights, were used to assess the relationship between parental distress, as assessed by the WHO Self Reporting Questionnaire (SRQ20), with height-for-age z score (HAZ), stunting, and behavioral and other risk factors for stunting. RESULTS: Maternal, paternal and parental distress (i.e. both maternal and paternal distress) were associated with reduced linear growth of the children by 0.086 (95% CI -0.17, -0.00), 0.11 (95% CI -0.24, -0.02) and 0.19 (95% CI -0.37, -0.00) HAZ-scores, respectively. Maternal and paternal distress increased the risk of mild stunting (HAZ <-1) by 33% (95% CI 1.17,1.50) and 37% (95% CI 1.18,1.60), and the risk of moderate stunting (HAZ <-2) by 25% (95% CI 1.10,1.43) and 28% (95% CI 1.08,1.51]), respectively. Parental stress increased the risk of moderate stunting by 40% (95% CI 1.06,1.85). Amongst specific groups of risk factors, the proportion of HAZ-score lost was associated with socioeconomic factors (30.3%) including, low wealth, low maternal occupational status, low maternal education, rural residence, and low paternal occupational status; physiological factors (15.5%) including low maternal height, low maternal mid-upper arm circumference, being male, low paternal height; behavioral factors (8.9%) including open garbage disposal, paternal smoking, not using iodized salt; and experiencing at least one infectious diseases episode (1.1%). CONCLUSIONS: Maternal, paternal and parental stress were associated with reduced linear growth of children. These findings highlight the complex etiology of stunting and suggest nutritional and other biomedical interventions are insufficient, and that promotion of mental and behavioral health programs for parents must be pursued as part of a comprehensive strategy to enhance child growth and development, i.e. improved caretaker capacity, integrated community development, improved parenting skills, as well as reduced gender discrimination, and domestic violence.


Assuntos
Estatura/fisiologia , Pais/psicologia , Pré-Escolar , Estudos Transversais , Escolaridade , Feminino , Transtornos do Crescimento/psicologia , Inquéritos Epidemiológicos , Humanos , Indonésia , Lactente , Masculino , Estado Nutricional/fisiologia , Prevalência , Angústia Psicológica , Fatores de Risco , População Rural , Fatores Socioeconômicos
2.
Nutrients ; 13(9)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34578914

RESUMO

Oral nutritional supplements (ONS) are used to promote catch-up growth in children with undernutrition. We conducted a systematic review and meta-analysis to summarize the evidence of ONS intervention effects on growth for 9-month- to 12-year-old children who were undernourished or at nutritional risk. Eleven randomized controlled trials met the inclusion criteria; trials compared changes in anthropometric measures in children using ONS or ONS + DC (dietary counselling) to measures for those following usual diet or placebo or DC alone. The RCTs included 2287 children without chronic diseases (mean age 5.87 years [SD, 1.35]; 56% boys). At follow-up time points up to 6 months, results showed that children in the ONS intervention group had greater gains in weight (0.423 kg, [95% confidence interval 0.234, 0.613], p < 0.001) and height (0.417 cm [0.059, 0.776], p = 0.022) versus control; greater gains in weight (0.089 kg [0.049, 0.130], p < 0.001) were evident as early as 7-10 days. Longitudinal analyses with repeated measures at 30, 60, and 90 days showed greater gains in weight parameters from 30 days onwards (p < 0.001), a trend towards greater height gains at 90 days (p = 0.056), and significantly greater gains in height-for-age percentiles and Z-scores at 30 and 90 days, respectively (p < 0.05). Similar results were found in subgroup analyses of studies comparing ONS + DC to DC alone. For children with undernutrition, particularly those who were mildly and moderately undernourished, usage of ONS in a nutritional intervention resulted in significantly better growth outcomes when compared to control treatments (usual diet, placebo or DC alone).


Assuntos
Estatura/efeitos dos fármacos , Suplementos Nutricionais , Desnutrição/tratamento farmacológico , Ganho de Peso/efeitos dos fármacos , Administração Oral , Estatura/fisiologia , Criança , Humanos , Ganho de Peso/fisiologia
3.
Nutrients ; 13(9)2021 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-34578949

RESUMO

In a retrospective review, we aimed to assess long-term growth in 17 patients (n = 11 males) with hereditary tyrosinaemia type I (HTI). Median age at assessment was 15.6 years (5.7-26.6 years) and median age at diagnosis was 1 month (range: 0-16 months), with 35% (n = 6/17) symptomatic on presentation. From the age of 8 years, there was a noticeable change in median height, weight, and body-mass-index [BMI]-z-scores. Median height-for-age z-scores were consistently ≤ -1 (IQR -1.6, -0.5) during the first 8 years of life but increased with age. Weight-for-age z-scores ranged between -1 to 0 (IQR -1.2, 0.1) in the first 8 years; then increased to > 0.5 (IQR -0.3, 1.3) by age 16 years, and BMI-for-age z-scores ranged from 0 to 1 (IQR -0.7, 1.3) up to 8 years, and >1 (IQR -0.2, 1.9) until 16 years. The percentage of overweight and obesity was lowest in children aged < 5 years, and consistently > 40% in patients aged between 7 to 16 years. The prescribed total protein intake was associated with improved height growth (p < 0.01). Impaired growth in early life improved with age achieving normal population standards. Further studies are needed to investigate factors that influence growth outcome in HTI patients.


Assuntos
Estatura/fisiologia , Índice de Massa Corporal , Peso Corporal/fisiologia , Sobrepeso/epidemiologia , Tirosinemias/epidemiologia , Tirosinemias/fisiopatologia , Adolescente , Adulto , Criança , Desenvolvimento Infantil/fisiologia , Pré-Escolar , Comorbidade , Feminino , Humanos , Estudos Longitudinais , Masculino , Sobrepeso/fisiopatologia , Estudos Retrospectivos , Reino Unido/epidemiologia , Adulto Jovem
4.
Pan Afr Med J ; 39: 155, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34539952

RESUMO

Penile length varies worldwide. It is necessary to determine penile length in our region to enable adequate counselling on normal length and reduce avoidable anxiety. Two hundred and seventy-one men were recruited with 97 men in group I and 174 men in group II. Mean ages were 38.4 ± 6.9 (21-50) years and 68 ± 9.1 (51-98) years. In group I, the mean flaccid penile length (FPL)-I and stretched penile length (SPL)-I were 9.8± 2.7 and 10.6± 2.2, mean height 1.7±0.07m and body mass index (BMI) 24.1±3.1 kg/m2. While in group II, mean FPL-II and SPL-II were 13.0± 2.9 and 14.1 ± 2.1, mean height was 1.69± 0.07m and BMI 24.3± 3.2 kg/m2. There were positive correlations between the SPL-I and heights in group I; (r=0.305, p<0.002); height and FPL-I (r = 0.218, P<0.032). Similarly, in group II positive correlations of FPL-II and SPL-II with height; r = 0.166 P<0.028 and r = 0.183, P<0.015. There was negative correlation SPL-II and BMI-II r-0.224, p<0.003. FLR-II and BMI-II, -0.157, p<0.039. In conclusion, Flaccid and stretched penile length of men < 50 years was smaller than those > 50 years. In both age groups, flaccid and stretched penile lengths correlated with height. In group II, penile lengths correlated negatively with BMI.


Assuntos
Estatura/fisiologia , Índice de Massa Corporal , Pênis/anatomia & histologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Valores de Referência , Adulto Jovem
5.
Nat Commun ; 12(1): 5613, 2021 09 23.
Artigo em Inglês | MEDLINE | ID: mdl-34556649

RESUMO

Assisted reproductive technologies (ART) are increasingly used, however little is known about the long-term health of ART-conceived offspring. Weak selection of comparison groups and poorly characterized mechanisms impede current understanding. In a prospective cohort (Growing Up in Singapore Towards healthy Outcomes; GUSTO; Clinical Trials ID: NCT01174875) including 83 ART-conceived and 1095 spontaneously-conceived singletons, we estimate effects of ART on anthropometry, blood pressure, serum metabolic biomarkers, and cord tissue DNA methylation by emulating a pragmatic trial supported by machine learning-based estimators. We find ART-conceived children to be shorter (-0.5 SD [95% CI: -0.7, -0.2]), lighter (-0.6 SD [-0.9, -0.3]) and have lower skinfold thicknesses (e.g. -14% [-24%, -3%] suprailiac), and blood pressure (-3 mmHg [-6, -0.5] systolic) at 6-6.5 years, with no strong differences in metabolic biomarkers. Differences are not explained by parental anthropometry or comorbidities, polygenic risk score, breastfeeding, or illnesses. Our simulations demonstrate ART is strongly associated with lower NECAB3 DNA methylation, with negative control analyses suggesting these estimates are unbiased. However, methylation changes do not appear to mediate observed differences in child phenotype.


Assuntos
Estatura/fisiologia , Peso Corporal/fisiologia , Sistema Cardiovascular/metabolismo , Aprendizado de Máquina , Técnicas de Reprodução Assistida/estatística & dados numéricos , Pregas Cutâneas , Adulto , Pressão Sanguínea/fisiologia , Proteínas de Ligação ao Cálcio/genética , Criança , Metilação de DNA , Feminino , Humanos , Fenótipo , Estudos Prospectivos , Singapura
6.
Sci Rep ; 11(1): 16093, 2021 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-34373470

RESUMO

Most published newborn growth references are based on conventional monitoring data that usually included both low- and high-risk pregnancies. We sought to develop a set of neonatal growth standards constructed from only a large sample of low-risk pregnancies. A total of 24,375 naturally conceived singleton live births with gestational ages of 24-42 weeks were collected in 69 hospitals in thirteen Chinese cities between 2015 and 2018. Unhealthy infants or those with high-risk mother were excluded. Smoothed percentile curves of six anthropometric indicators were established using the Generalized Additive Model for Location, Scale and Shape. The 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile references for birth weight, length, head circumference, weight/length, body mass index, and ponderal index were calculated for neonates with gestational ages of 24-42 weeks. This set of neonatal growth standards with six anthropometric indicators can provide more tools for growth and nutrition assessment and body proportionality in neonatal clinical practice. These standards might also help to show the differences between growth curves based on low-risk and mixed low- and high-risk pregnancies.


Assuntos
Peso ao Nascer/fisiologia , Estatura/fisiologia , Desenvolvimento Fetal/fisiologia , Adulto , Antropometria/métodos , Índice de Massa Corporal , Cefalometria/normas , China , Cidades , Estudos Transversais , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Valores de Referência
7.
Int J Obes (Lond) ; 45(10): 2269-2273, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34267325

RESUMO

BACKGROUND AND OBJECTIVES: COVID-19-related school closures may increase the prevalence of childhood obesity, which has aroused public concerns. We aimed to analyze the weight and height changes in Chinese preschool children during the COVID-19-related school closures period. METHODS: A total of 124,603 children from multi-city kindergartens in China were included in this study. We evaluated the prevalence of overweight and obese in preschool children experienced school closures, and compared the changes in BMI, weight, and height of preschool children among COVID-19 school closures period, the same period last year and the same period the year before last. RESULTS: After the school closures, childhood obesity prevalence increased, whereas overweight prevalence decreased. During school closures, the average increase in height was about 1 cm less as compared with the same period last year and the year before last, but no noteworthy difference in the weight change was observed among the three periods. CONCLUSIONS: During COVID-19 school closures, children's height increase seemed to be more affected than weight change. Innovative, robust, and highly adaptable strategies should be taken to increase physical activity, reduce sedentary time and promote healthy diets, to minimize the adverse impact of school closures.


Assuntos
Estatura/fisiologia , Peso Corporal/fisiologia , COVID-19 , Obesidade Pediátrica/epidemiologia , Pré-Escolar , Controle de Doenças Transmissíveis , Feminino , Humanos , Masculino , Sobrepeso/epidemiologia , Estudos Retrospectivos , Instituições Acadêmicas
8.
PLoS One ; 16(7): e0254659, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34310636

RESUMO

The purpose of the study was to evaluate predicted maturity offset (time before age at PHV) and age at PHV (chronological age [CA] minus maturity offset) in a longitudinal sample of 58 under-13 club level soccer players in central Portugal for whom ages at PHV were estimated with the SITAR model. Two maturity offset prediction equations were applied: the original equation which requires CA sitting height, estimated leg length, height and weight, and a modified equation which requires CA and height. Predicted maturity offset increased, on average, with CA at prediction throughout the age range considered, while variation in predicted maturity offset and ages at PHV within CA groups was considerably reduced compared to variation in observed ages at offset and at PHV. Predicted maturity offset and ages at PHV were consistently later than observed maturity offset and age at PHV among early maturing players, and earlier than observed in late maturing players. Both predicted offset and ages at PHV with the two equations were, on average, later than observed among players maturing on time. Intra-individual variation in predicted ages at PHV with each equation was considerable. The results for soccer players were consistent with similar studies in the general population and two recent longitudinal studies of soccer players. The results question the utility of predicted maturity offset and age at PHV as valid indicators of maturity timing and status.


Assuntos
Atletas , Desempenho Atlético/fisiologia , Estatura/fisiologia , Futebol/fisiologia , Adolescente , Fatores Etários , Antropometria , Criança , Humanos , Masculino , Portugal/epidemiologia , Reologia , Maturidade Sexual/fisiologia
9.
Sci Rep ; 11(1): 14255, 2021 07 09.
Artigo em Inglês | MEDLINE | ID: mdl-34244570

RESUMO

Congenital Heart Defects (CHDs) are associated with different patterns of malnutrition and growth retardation, which may vary worldwide and need to be evaluated according to local conditions. Although tetralogy of Fallot (TOF) is one of the first described CHDs, the etiology outcomes in growth and development of TOF in early age child is still unclear in most cases. This study was designed to investigate the growth retardation status of Chinese pediatric TOF patients under 5 years old. The body height, body weight and body mass index (BMI) of 262 pediatric patients (138 boys and 124 girls) who underwent corrective surgery for TOF between 2014 and 2018 were measured using conventional methods. The average body height, body weight and BMI of the patients were significantly lower than WHO Child Growth Standards, while the most affected was body height. Meanwhile, higher stunting frequency and greater deterioration of both the body height and weight happened in elder age (aged 13-60 months) rather than in infant stage (aged 0-12 months) among these patients. Our results confirmed that intervention should be given at early age to prevent the growth retardation of TOF patients getting severer.


Assuntos
Tetralogia de Fallot/epidemiologia , Estatura/fisiologia , Peso Corporal/fisiologia , Pré-Escolar , China , Feminino , Humanos , Lactente , Recém-Nascido , Masculino
10.
Medicine (Baltimore) ; 100(23): e26274, 2021 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-34115026

RESUMO

ABSTRACT: This study aimed to explore the characteristics of changes in the sagittal arrangement of the spine between adolescent patients with idiopathic scoliosis (AIS) and normal adolescents, the risk factors for AIS and the factors affecting the progress of AIS.X-ray images of the full length of the spine in standing position were taken in AIS patients and normal adolescents. Radiographic measurements made at intermediate follow-up included the following:C1 and C2 cervical lordosis and C2 - C7 curvature of cervical lordosis, C2-C7sagittal horizontal distance (C2-C7SagittalVerticalAxis, C2-C7SVA), TS-CL, after thoracic lobe (Thoracic Kyphosis, TK), thoracic lumbar segment Angle (thoracolumbar kyphosis, [TLK]), lumbar lordosis Angle (Lumbar Lordosis, LL), sacral slope Angle (Sacrum Slope, SS), pelvic tilt Angle (Pelvic Tilt, PT), pelvic incidence (PI), L5 Incidence (Lumbar5 Slope (L5S), L5 incidence (Lumbar5 Incidence (L5I), sagittal horizontal distance (CSVA), lower depression Angle of the 2nd cervical spine. The difference of sagittal plane parameters between AIS group and normal adolescent group was compared. To evaluate the progress of AIS, correlation analysis was conducted between diagonal 2 and other parameters. The main risk factors of AIS were determined by binary Logistic analysis.The CSVA of AIS patients was higher than that of healthy adolescents (AIS: 27.64 ±â€Š19.56) mm. Healthy adolescents: (17.74 ±â€Š12.8) mm), L5S (AIS: 19.93°= 7.07° and healthy adolescents: 15.38°= 7.78°, P = .024 < .05), C2 downward sag Angle (AIS: 15.12°= 2.7°;Healthy adolescents: 12.97°= 4.56°); AIS patients had lower TS-CL (AIS: 22.48 ±â€Š6.09 and healthy adolescents: 28.26°= 10.32°), PT (AIS: 10.42°= 4.53° and healthy adolescents: 15.80°=7.68°), (AIS: 41.87°=9.72° and healthy adolescents: 48.75°= 8.22°). The main risk factor for idiopathic scoliosis in adolescents was L5 (OR = 1.239, 95%CI = 1.049-1.463, P = .012 < .05).L5S is a major risk factor for idiopathic scoliosis in adolescents. The larger PI is, the higher the risk of scoliosis progression is. In AIS patients, lumbar lordosis is increased, cervical lordosis is reduced, and even cervical kyphosis occurs.


Assuntos
Estatura/fisiologia , Radiografia/métodos , Medição de Risco , Escoliose , Coluna Vertebral/diagnóstico por imagem , Adolescente , Biometria/métodos , Vértebras Cervicais/diagnóstico por imagem , Progressão da Doença , Feminino , Humanos , Vértebras Lombares/diagnóstico por imagem , Masculino , Medição de Risco/métodos , Medição de Risco/estatística & dados numéricos , Fatores de Risco , Escoliose/diagnóstico por imagem , Escoliose/patologia , Coluna Vertebral/patologia
11.
J Sports Med Phys Fitness ; 61(6): 818-828, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34110120

RESUMO

BACKGROUND: Anthropometric and demographic properties may affect balance, but there is no consensus on this subject; so, there is a need for studies that explore it. This study aimed to assess the relationship between balance and anthropometric as well as demographic properties; and to determine the effect of anthropometric and demographic properties on balance in healthy adults. METHODS: Sixty healthy adults were included in this study. The ages of the participants were questioned; height, body weight, Body Mass Index, head circumference, upper extremity, lower extremity, and foot length were evaluated, and shoe numbers were recorded. Balance assessments were performed with the Balance Master System device. RESULTS: The mean age of the participants was 23.50±1.97 years. The balance developed with age (P<0.05), while there was a negative correlation between height and balance (P<0.05). Weight gain affected balance negatively (P<0.05). The increase in head circumference, extremity, and foot length was associated with a deterioration in balance (P<0.05). CONCLUSIONS: The results of the current study were showed that anthropometric and demographic properties affect balance. The increase in some of the anthropometric and demographic properties including height, weight, head circumference, extremity, and foot length harms the balance. During balance assessments, anthropometric and demographic characteristics should be considered as a factor that affects balance.


Assuntos
Antropometria/métodos , Equilíbrio Postural/fisiologia , Adulto , Estatura/fisiologia , Índice de Massa Corporal , Peso Corporal/fisiologia , Extremidades/fisiologia , Feminino , Humanos , Masculino , Adulto Jovem
12.
Nutrients ; 13(5)2021 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-34065650

RESUMO

Nutritional status affects linear growth and development. However, studies on the associations between nutritional status, diet quality, and age-standardized height in children are limited. The aim of this study was to assess the relationship between macro- and micronutrient intake and food consumption and height-for-age Z score (HAZ) among US children in the National Health and Nutrition Examination Survey (NHANES). This cross-sectional population-based study included 6116 US children aged 2-18 years. The usual dietary intake of nutrients and food groups was estimated by the multiple source method (MSM) using two-day food consumption data from NHANES 2007-2014. After adjusting for covariates, HAZ was positively associated with intakes of energy, protein, carbohydrate, fat, vitamins A, D, E, B6, and B12, thiamin, riboflavin, niacin, calcium, and iron. Children in the highest tertile of HAZ were less likely to consume lower than the EAR for vitamin E and calcium. Major foods consumed by children with lower HAZ were soft drinks, high-fat milk products, cakes, cookies, pastries, and pies, whereas children with higher HAZ tended to consume low-fat milk products, tea, and low-calorie fruit juice. These findings suggest that adequate nutritional intake, diet quality, and nutrient-dense food are important factors for height in children.


Assuntos
Fatores Etários , Estatura/fisiologia , Dieta Saudável/estatística & dados numéricos , Ingestão de Alimentos/fisiologia , Estado Nutricional , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Feminino , Gráficos de Crescimento , Humanos , Masculino , Inquéritos Nutricionais , Valores de Referência , Estados Unidos
13.
Medicine (Baltimore) ; 100(22): e26174, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34087881

RESUMO

ABSTRACT: Percutaneous vertebroplasty (VP) and kyphoplasty (KP) are well-established minimally invasive surgical procedures for the treatment of osteoporotic vertebral compression fractures (OVCF). However, some drawbacks have been reported regarding these procedures, including height loss, cement leakage, and loss of the restored height after balloon deflation. We performed a novel VP technique to minimize these limitations of conventional procedures. This study aimed to compare radiological and clinical outcomes of our method using a larger-diameter needle versus conventional VP (using a smaller needle) for thoracolumbar OVCF.From April 2016 to May 2017, 107 consecutive patients diagnosed with thoracolumbar OVCF were enrolled. Patients were divided into two groups: group 1 underwent conventional VP, i.e., using a smaller diameter needle, and group 2 underwent VP through a modified method with a larger-diameter needle. For radiological evaluation, parameters related to anterior vertebral height (AVH) and segmental angle were assessed using plain standing radiographs, and patient-reported outcomes were evaluated using the visual analog scale. Cement injection amount and leakage pattern were also analyzed. Group 2 showed a larger anterior vertebral height change than group 1 immediately postoperatively and one year postoperatively. The 1-year postoperatively-AVH maintained better in group 2 than in group 1. Group 2 showed more significant improvement of segmental angle immediately postoperatively than group 1 (3.15° in group 1 vs 9.36° in group 2). IYPo-visual analog scale significantly improved in both groups, with greater improvement in group 2 (3.69 in group 1 vs 5.63 in group 2). A substantially larger amount of cement was injected, with a lower leakage rate in group 2 than in group 1.A novel VP technique using a larger-diameter needle showed superior radiological and clinical outcomes than conventional VP. Therefore, it can be considered a useful treatment option for OVCF.


Assuntos
Fraturas por Compressão/cirurgia , Agulhas/efeitos adversos , Fraturas por Osteoporose/cirurgia , Fraturas da Coluna Vertebral/cirurgia , Vertebroplastia/métodos , Idoso , Estatura/fisiologia , Cimentos Ósseos/efeitos adversos , Cimentos Ósseos/uso terapêutico , Estudos de Casos e Controles , Feminino , Fraturas por Compressão/diagnóstico , Fraturas por Compressão/etiologia , Humanos , Cifoplastia/métodos , Vértebras Lombares/cirurgia , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Agulhas/estatística & dados numéricos , Fraturas por Osteoporose/complicações , Fraturas por Osteoporose/diagnóstico , Medidas de Resultados Relatados pelo Paciente , Radiografia/métodos , Estudos Retrospectivos , Fraturas da Coluna Vertebral/diagnóstico , Vértebras Torácicas/cirurgia , Vertebroplastia/estatística & dados numéricos , Escala Visual Analógica
14.
J Bone Joint Surg Am ; 103(16): 1543-1551, 2021 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-33974573

RESUMO

BACKGROUND: The onset of peak height velocity (PHV) guides the timing of interventions in the growing child. The purpose of the present study was to validate the Diméglio olecranon grading system and to compare these scores with the Risser/triradiate closure (TRC), proximal humerus, and Sanders hand scores. METHODS: Eighty children with annual serial radiographs were selected from the Bolton-Brush collection. The olecranon apophysis was graded with use of lateral radiographs of the elbow. The mean age to PHV was determined for each stage, and reliability was calculated with use of an intraclass correlation coefficient (ICC). Olecranon stage was combined with age, sex, and height in a generalized estimating equation (GEE) model to predict PHV. Predictive performance of this model was evaluated with use of tenfold cross-validation such that the model was trained on 90% of the radiographs and was asked to predict the PHV of the remaining 10%. RESULTS: PHV is closely associated with olecranon stage, with stage 1 occurring 3.0 years before PHV and stage 7 occurring 3.4 years after PHV. Stage 5 was found to occur at PHV. Scoring system reliability was high across an array of observers (ICC = 0.85 ± 0.07). The GEE model showed that this olecranon system outperforms the Risser/TRC system in predicting PHV and is comparable with the humerus and Sanders hand systems. When combined with age and sex, the olecranon system successfully predicted PHV such that 62% of PHV predictions were accurate within 6 months and 90% of PHV predictions were accurate within a year. CONCLUSIONS: Our data show that stage 5 occurs at PHV, contrary to previously published data. When combined with age and sex, the olecranon system successfully predicts PHV within a year in 90% of cases, establishing a single lateral view of the olecranon as a simple alternative to more complex grading systems. Last, we describe novel 3 variations in olecranon morphology and provide a guide for accurate olecranon staging. CLINICAL RELEVANCE: Understanding PHV is critical in the treatment of many pediatric orthopaedic disorders. The revised olecranon staging system will allow for more accurate determination of this variable.


Assuntos
Determinação da Idade pelo Esqueleto/métodos , Estatura/fisiologia , Olécrano/fisiologia , Osteogênese/fisiologia , Adolescente , Criança , Estudos de Viabilidade , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Estudos Retrospectivos
15.
Pediatr Rheumatol Online J ; 19(1): 71, 2021 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-33980256

RESUMO

BACKGROUND: Among school-age children, the decrease of cartilage thickness (Cth) with increasing age is well known. However, the influence of body mass index (BMI), height or weight on Cth has not been revealed. Here in, we aim to establish an age- and gender-specific Cth standard reference among Asians and investigate the possible prestige of BMI, height and weight. METHODS: A cross-sectional study was performed in healthy Asian children. Bilateral knees, ankles, wrists, second metacarpophalangeals (MCPs) and proximal interphalangeals (PIPs) were measured using ultrasound. The children's height, weight and BMI were also recorded for later adjustment. RESULTS: A total of 200 school age Asian children (including 86 girls and 114 boys, aged between 5 to 13 years-old) were investigated. Cth differences were observed in the knees, ankles, wrists, MCPs and PIPs between sexes (p < 0.05), with girls having thinner cartilage thickness. While Cth decreases with increasing age (p < 0.0001, 0.039, 0.001, 0.023, 0.091 in girls' knees, ankles, wrists, MCPs and PIPs and p = 0.002, 0.001, < 0.0001, 0.001, 0.045 in boys', respectively). Our data showed that weight, height and BMI are not the main factors contributing to Cth. A formula to calculate gender-specific cartilage thickness for Asian school age children is suggested. There was no difference in Cth after adjusting for height or weight between Asian or Caucasian group. CONCLUSIONS: A formula to calculate gender-specific cartilage thickness for Asian school age children is suggested. Height, weight and BMI were not the major contributor for Cth among school age children.


Assuntos
Cartilagem Articular , Articulações , Ultrassonografia/métodos , Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , Estatura/fisiologia , Índice de Massa Corporal , Peso Corporal/fisiologia , Cartilagem Articular/diagnóstico por imagem , Cartilagem Articular/patologia , Criança , Desenvolvimento Infantil/fisiologia , Estudos Transversais , Feminino , Humanos , Articulações/diagnóstico por imagem , Articulações/crescimento & desenvolvimento , Masculino , Tamanho do Órgão , População , Padrões de Referência , Taiwan/epidemiologia
16.
S Afr Med J ; 111(2): 166-170, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33944728

RESUMO

BACKGROUND: The weight of a patient is an important variable that impacts on their medical care. Although some drugs are prescribed on a so-called 'adult dose' basis, we know that adults come in all shapes and sizes - a 'one-dose-fits-all' approach is not necessarily appropriate. As a measured weight may not always be available, an alternative method of accurately estimating weight is required. OBJECTIVES: To assess and compare the accuracy of weight estimations in adults by patient self-estimation, the Mercy method, Buckley method, Broca index and PAWPER XL-MAC (paediatric advanced weight prediction in the emergency room eXtra length/eXtra large mid-arm circumference) method. METHODS: This was a prospective, cross-sectional study conducted at a tertiary academic hospital in a metropolitan area of Johannesburg, South Africa. Anthropometric variables of height, abdominal circumference, thigh circumference, mid-arm circumference and humeral length were measured. These variables were then applied to the various weight estimation methods and compared with the patient's actual weight. RESULTS: There were 188 adult patients included in the study. None of the methodologies evaluated in this study achieved the recommended >70% of weight estimations within 10% of the patient's actual weight (PW10). The Mercy method was the closest to achieving greater than the recommended 95% for weight estimation falling within 20% of the patient's actual weight (PW20). The PW20 for the Mercy method was 91.5%. The PAWPER XL-MAC and patient self-estimate methods achieved a PW20 of 85.1% and 86.1%, respectively. The Broca and Buckley methods performed poorly overall. CONCLUSIONS: None of the evaluated weight estimation methodologies was accurate enough for use in adult weight estimation. The Mercy and PAWPER XL-MAC methodologies both showed significant promise for use in adult weight estimation, but need further refinement. Although patient self-estimates were similarly accurate to those found in previous studies, they were not an accurate option; self-estimations would remain the first choice if the patient was able to provide such an estimation. The Broca index and Buckley method cannot be recommended owing to their poor performance.


Assuntos
Antropometria/métodos , Peso Corporal/fisiologia , Pesos e Medidas Corporais/métodos , Estatística como Assunto/métodos , Adulto , Estatura/fisiologia , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Variações Dependentes do Observador , Estudos Prospectivos , África do Sul
17.
Biomed Res Int ; 2021: 6640026, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33997034

RESUMO

Objective: To identify the aetiology of growth and development diseases and assess the long-term effectiveness of recombinant human growth hormone (rhGH) therapy in a real-life clinical setting and provide better guidance in clinical strategy and decision making. Methods: This retrospective study included 1145 children and adolescents with short stature admitted to the Department of Endocrinology, Affiliated Hospital of Jining Medical University, from January 2013 to December 2019, of whom 484 received rhGH treatment. The related anthropometrics and laboratory examinations were assessed in all participants. Results: A total of 1145 children and adolescents with short stature aged 10.5 ± 3.3 years, including 740 boys and 405 girls, were analysed in this study. The number of children and adolescents with short stature gradually increased per year from 2013 to 2019. The mean pretreatment height standard deviation score (SDS) and insulin-like growth factor-1 SDS were -2.93 ± 1.05 and -1.01 (-1.83--0.16), respectively. The majority of the children (658, 57.47%) were prepubescent. In total, 484 subjects aged 10.6 ± 3.2 years received rhGH and were followed up, and among them, 292 children were treated for more than one year. As the treatment time increased, the children's height SDS gradually increased, and most of them attained a height SDS within the normal range. The mean height SDS in children who were treated for more than one year was -3.0 ± 1.0 at baseline and gradually increased to -0.8 ± 0.3 by year 6. The results were consistent across subgroups of different aetiologies of short stature. Conclusions: Increasing attention has been given to the height of children during the period of 2013-2019 in eastern China. The present findings indicate that children with short stature need to be referred to a specialist centre to diagnose the cause of growth failure and that short children receiving rhGH therapy show a significant increase in height over time.


Assuntos
Estatura/fisiologia , Transtornos do Crescimento , Adolescente , Criança , China , Feminino , Transtornos do Crescimento/diagnóstico , Transtornos do Crescimento/tratamento farmacológico , Transtornos do Crescimento/fisiopatologia , Hormônio do Crescimento Humano/uso terapêutico , Humanos , Masculino , Estudos Retrospectivos
18.
Sci Rep ; 11(1): 9524, 2021 05 04.
Artigo em Inglês | MEDLINE | ID: mdl-33947900

RESUMO

This study was performed to evaluate the waist-to-height ratio (WHtR) distribution and assess its relationship with cardiometabolic risk in children and adolescents. A total of 8091 subjects aged 10-18 years were included from a nationally representative survey. Participants were classified into three groups: (1) < 85th, (2) ≥ 85th and < 95th, and (3) ≥ 95th percentile of WHtR. The WHtR distribution varied with sex and age. Whereas WHtR decreased from age 10-15 years in boys and from age 10-12 years in girls, it slightly increased thereafter. Compared to the < 85th percentile group, the WHtR ≥ 85th and < 95th percentile group had an odds ratio (OR) of 1.2 for elevated blood pressure (BP), 1.89 for elevated triglycerides (TGs), 1.47 for reduced high-density lipoprotein cholesterol (HDL-C) and 4.82 for metabolic syndrome (MetS). The ≥ 95th percentile group had an OR of 1.4 for elevated BP, 2.54 for elevated glucose, 2.22 for elevated TGs, 1.74 for reduced HDL-C, and 9.45 for MetS compared to the < 85th percentile group. Our results suggest that sex- and age-specific WHtR percentiles can be used as a simple clinical measurement to estimate cardiometabolic risk.


Assuntos
Estatura/fisiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/fisiopatologia , Circunferência da Cintura/fisiologia , Adolescente , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Doenças Cardiovasculares/metabolismo , Criança , HDL-Colesterol/metabolismo , Feminino , Humanos , Hipertensão/metabolismo , Hipertensão/fisiopatologia , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/metabolismo , Síndrome Metabólica/fisiopatologia , Obesidade Abdominal/complicações , Obesidade Abdominal/metabolismo , Obesidade Abdominal/fisiopatologia , Fatores de Risco , Triglicerídeos/metabolismo , Razão Cintura-Estatura
19.
Indian Heart J ; 73(1): 22-25, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33714405

RESUMO

Atrial fibrillation (AF) is characterized by abnormal heart rhythm. Among other well-known associations, recent studies suggest an association of AF with height. Height is related to 50 diseases spanning different body systems, AF is one of them. Since AF, a heterogeneous disease process, is influenced by structural, neural, electrical, and hemodynamic factors, height alters this process through its contribution to increasing atrial and ventricular size, leading to altered conduction patterns, autonomic dysregulation, and development of AF. Multiple underlying mechanisms associate height with AF. Apart from these indirect mechanisms, genome-wide association studies suggest the involvement of the same genes in AF and growth pathways. Tall stature is independently associated with a higher risk of AF development in healthy individuals. Since adult height is achieved much earlier than the onset of AF, protective measures can be taken in individuals with increased height to monitor, manage, and prevent the progression of AF.


Assuntos
Fibrilação Atrial/fisiopatologia , Estatura/fisiologia , Frequência Cardíaca/fisiologia , Humanos , Fatores de Risco
20.
Rev Paul Pediatr ; 39: e2020076, 2021.
Artigo em Inglês, Português | MEDLINE | ID: mdl-33656144

RESUMO

OBJECTIVE: To evaluate the prevalence of breastfeeding (BF) and the association between occurrence/duration of BF and overweight/obesity in schoolchildren aged 7-14 years. METHODS: This is a cross-sectional study, conducted in 2012-2013, on schoolchildren aged 7-14 years from Florianópolis, Santa Catarina, Southern Brazil. Weight and height were measured according to procedures of the World Health Organization. Breastfeeding and sociodemographic data were obtained from a questionnaire responded by parents/guardians. BF was categorized as a dichotomous variable (yes/no) and according to duration (months). Nutritional status was evaluated according to the Z score of the body mass index per age for sex and it was categorized into two groups: normal weight (

Assuntos
Aleitamento Materno/estatística & dados numéricos , Estado Nutricional/fisiologia , Obesidade/epidemiologia , Sobrepeso/epidemiologia , Adolescente , Adulto , Estatura/fisiologia , Índice de Massa Corporal , Peso Corporal/fisiologia , Brasil/epidemiologia , Aleitamento Materno/efeitos adversos , Estudos de Casos e Controles , Criança , Ciências da Nutrição Infantil/estatística & dados numéricos , Estudos Transversais , Feminino , Humanos , Masculino , Mães/estatística & dados numéricos , Obesidade/etiologia , Sobrepeso/etiologia , Prevalência , Inquéritos e Questionários/estatística & dados numéricos , Fatores de Tempo
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