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1.
J Laryngol Otol ; 133(8): 691-695, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31284886

RESUMO

OBJECTIVE: This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis. METHOD: This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters. RESULTS: The median calprotectin value of the active lesion group (80.5 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017). CONCLUSION: In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.


Assuntos
Biomarcadores/sangue , Complexo Antígeno L1 Leucocitário/sangue , Estomatite Aftosa/diagnóstico , Adulto , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Recidiva , Estomatite Aftosa/sangue
2.
Shanghai Kou Qiang Yi Xue ; 28(1): 53-56, 2019 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-31081000

RESUMO

PURPOSE: To evaluate the risk factors for the occurrence of recurrent aphthous ulcer (RAU) in Fuzhou city by case-control study. METHODS: A questionnaire survey of 113 patients with RAU and 102 non-RAU patients in the same hospital was made, including 58 items. Chi-square test and conditional logistic regression were used for monovariate and multivariate analysis respectively with SPSS23.0 software package. RESULTS: One-way Chi-square test showed that immigrants, genetic factors, gastrointestinal disorders, menstrual period, oral health status, anxiety were related factors for patients suffering from RAU. Conditional logistic regression analysis indicated that genetic factors as well as more dental calculus in the oral cavity were RAU risk factors. Tendency Chi-square test revealed that there was a negative correlation between the occurrence of RAU and vegetable intake, and a positive correlation with the amount of dental calculus and soft scale in the oral cavity. CONCLUSIONS: The occurrence of RAU is the result of combination of "multiple factors" in the digestive system, genetic system, immune system and oral microenvironment.


Assuntos
Estomatite Aftosa , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Humanos , Recidiva , Fatores de Risco , Estomatite Aftosa/patologia
3.
Carbohydr Res ; 477: 51-57, 2019 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-30974304

RESUMO

BACKGROUND: Recurrent aphthous stomatitis being the most common chronic disease of the oral cavity affects 5-25% of the population. AIM: This study goals to develop a novel polymeric excipient based on alginate with enhanced mucoadhesion and controlled release for buccal therapy of aphthae. METHODS: Sulfhydryl groups of amino acid cysteine (SH) was anchored on the polymeric backbone of alginate (AL). Furthermore, mucoadhesiveness, stability and release profile as well as permeation of ambroxol through buccal mucosa were examined. RESULTS: Sulfhydryl anchored alginate was successfully synthesized. The stability was 3.52-fold improved in presence of sulfhydryl anchored alginate compared to alginate. Mucoadhesive studies revealed an 11.56-fold augmentation in adhesion time with AL-SH instead of AL. Ambroxol showed a 1.4-fold controlled release in presence of AL-SH and AL, respectively. The permeation profile of ambroxol was 1.89-fold higher in case of AL-SH compared to AL. CONCLUSION: The obtained AL-SH will pave the pathway for the aphthae therapy.


Assuntos
Alginatos/farmacologia , Sistemas de Liberação de Medicamentos , Mucosa Bucal/efeitos dos fármacos , Estomatite Aftosa/tratamento farmacológico , Compostos de Sulfidrila/farmacologia , Adesividade/efeitos dos fármacos , Alginatos/química , Humanos , Compostos de Sulfidrila/química
4.
Transplant Proc ; 51(3): 993-997, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30979493

RESUMO

Recipients of organ transplants are immunosuppressed and at high risk of oral infection. Oral diseases are often neglected compared with infections of other organs that typically confer higher morbidity. However, severe local symptoms hinder oral intake, decrease quality of life, and are sometimes lethal. Here we describe a case of a 57-year-old woman who developed recurrent aphthous stomatitis after kidney transplantation; the cause of the infection was complex and included cytomegalovirus, herpes simplex virus, and Candida species. Since misdiagnosis of oral diseases impairs patient quality of life and increases morbidity, clinicians should be aware of possible etiologies of oral infections in renal transplant recipients.


Assuntos
Candida , Citomegalovirus , Transplante de Rim/efeitos adversos , Simplexvirus , Estomatite Aftosa/etiologia , Transplantados , Candidíase/complicações , Candidíase/microbiologia , Infecções por Citomegalovirus/complicações , Infecções por Citomegalovirus/virologia , Feminino , Herpes Simples/complicações , Herpes Simples/virologia , Humanos , Pessoa de Meia-Idade , Estomatite Aftosa/diagnóstico
5.
Nat Commun ; 10(1): 1052, 2019 03 05.
Artigo em Inglês | MEDLINE | ID: mdl-30837455

RESUMO

Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%). This study finds 97 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an independent cohort (n = 355,744) (lead variant after meta-analysis: rs76830965, near IL12A, OR 0.72 (95% CI: 0.71, 0.73); P = 4.4e-483). Additional effect estimates from three independent cohorts with more specific phenotyping and specific study characteristics support many of these findings. In silico functional analyses provide evidence for a role of T cell regulation in the aetiology of mouth ulcers. These results provide novel insight into the pathogenesis of a common, important condition.


Assuntos
Loci Gênicos/imunologia , Predisposição Genética para Doença , Fatores Imunológicos/genética , Úlceras Orais/genética , Estomatite Aftosa/genética , Adulto , Idoso , Estudos de Coortes , Simulação por Computador , Feminino , Estudo de Associação Genômica Ampla , Humanos , Fatores Imunológicos/imunologia , Masculino , Pessoa de Meia-Idade , Úlceras Orais/imunologia , Estomatite Aftosa/imunologia , Linfócitos T/imunologia
6.
Rev. bras. med. fam. comunidade ; 14(41): e1815, 02/2019. ilus, tab
Artigo em Português | LILACS, Coleciona SUS | ID: biblio-986445

RESUMO

Objetivo: Apresentar informações sobre o diagnóstico e tratamento da síndrome PFAPA na Atenção Primária à Saúde. Métodos: Revisão sistemática de literatura baseada na recomendação PRISMA e realizada nas bases de dados Scielo, Lilacs, Medline, IBECS e PubMed, incluindo estudos publicados no período de 2004 a 2018, além da consulta a outros documentos específicos da síndrome PFAPA. Resultados: Após busca e seleção, foram incluídos 31 artigos. Avaliação e Diagnóstico: A síndrome PFAPA acomete principalmente crianças, sendo caracterizada por febre periódica acompanhada por faringite, estomatite aftosa e/ou adenite cervical. Seu diagnóstico é clínico e por exclusão, baseado em critérios estabelecidos. Recomendações: Os episódios costumam responder a prednisona e, em graus variáveis, a cimetidina e colchicina. Casos refratários e acompanhados de hipertrofia tonsilar são candidatos a tonsilectomia, devendo ser encaminhados à avaliação otorrinolaringológica.


Objective: To present information about the diagnosis and treatment of PFAPA syndrome in Primary Health Care. Methods: Systematic review of literature based on the PRISMA recommendation and carried out in the Scielo, Lilacs, Medline, IBECS and PubMed databases, including studies published from 2004 to 2018, in addition to consulting other PFAPA syndrome specific documents. Results: After search and selection, 31 articles were included. Assessment and Diagnosis: PFAPA syndrome affects mainly children and is characterized by periodic fever accompanied by pharyngitis, aphthous stomatitis and/or cervical adenitis. Its diagnosis is clinical and by exclusion, based on established criteria. Recommendations: The episodes usually respond to prednisone and, in varying levels, cimetidine and colchicine. Refractory cases and accompanied by tonsillar hypertrophy are candidates for tonsillectomy, and should be referred to otorhinolaryngological evaluation.


Objetivo: Presentar informaciones sobre el diagnóstico y tratamiento del síndrome PFAPA en la Atención Primaria a la Salud. Métodos: Revisión sistemática de literatura basada en la recomendación PRISMA y realizada en las bases de datos Scielo, Lilacs, Medline, IBECS y PubMed, incluyendo estudios publicados en el período 2004 a 2018, además de la consulta a otros documentos específicos del síndrome PFAPA. Resultados: Después de la búsqueda y selección, se incluyeron 31 artículos. Evaluación y Diagnóstico: El síndrome PFAPA acomete principalmente niños, siendo caracterizada por fiebre periódica acompañada por faringitis, estomatitis aftosa y/o adenitis cervical. Su diagnóstico es clínico y por exclusión, basado en criterios establecidos. Recomendaciones: Los episodios suelen responder a la prednisona y, en grados variables, a la cimetidina y colchicina. Los casos refractarios y acompañados de hipertrofia tonsilar son candidatos a tonsilectomía, debiendo ser encaminados a la evaluación otorrinolaringológica.


Assuntos
Atenção Primária à Saúde , Febre Recorrente , Estomatite Aftosa , Faringite , Linfadenite
8.
Medicine (Baltimore) ; 98(3): e14039, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30653111

RESUMO

BACKGROUND: Recurrent aphthous stomatitis (RAS) is one of the most common inflammatory ulcerative conditions of oral cavity with uncertain etiology. Several studies have reported that oxidative stress may be associated with RAS. The aim of this study was to compare the serum levels of total antioxidant status (TAS), nitric oxide (NO) and nitric oxide synthase (NOS) in minor RAS (MiRAS) patients with healthy individuals and determine the possible association of MiRAS with the 3 physiological parameters mentioned above. METHODS: Ninety patients with idiopathic MiRAS and 90 race-, age- and sex-matched healthy individuals were included in this study. All these subjects were allocated to 3 groups: MiRAS patients in the active stage (Group A); the same MiRAS patients in Group A in the inactive stage (Group B); healthy individuals without MiRAS (Group C). Serum levels of TAS, NO and NOS were determined by the spectrophotometric method. Independent sample t test and paired t test were performed for statistical evaluation. RESULTS: Serum TAS level of Group A was significantly decreased than that of Group C, whereas the serum level of NO was significantly higher in Group A as compared to Group C (P < .05). The serum levels of TAS and NO in Group B were no significant differences when compared with those in Group A or Group C. No significant differences in NOS activities were also found between the 3 groups (P > .05). CONCLUSIONS: MiRAS is associated with decreased TAS and increased NO levels, but NOS may not play an important role in the aetiopathogenesis.


Assuntos
Antioxidantes/análise , Óxido Nítrico Sintase/sangue , Óxido Nítrico/sangue , Estomatite Aftosa/sangue , Adulto , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Adulto Jovem
9.
Presse Med ; 48(1 Pt 2): e77-e87, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30683466

RESUMO

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is a complex autoinflammatory disease with a clinical phenotype characterised by recurrent episodes of fever, systemic inflammation and symptoms and signs depicted in disease acronym. Although PFAPA is the most common autoinflammatory disease among children in many parts of the world, the condition is still an enigma, which include the regular episodes, the prompt responses to corticosteroids, the genetic bases for the familial clustering and therapeutic effects of tonsillectomy. This review explores PFAPA syndrome with the aim of describing the current clinical and scientific understanding of the condition.


Assuntos
Doenças Hereditárias Autoinflamatórias , Corticosteroides/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Terapia Combinada , Diagnóstico Diferencial , Febre/etiologia , Predisposição Genética para Doença , Doenças Hereditárias Autoinflamatórias/classificação , Doenças Hereditárias Autoinflamatórias/diagnóstico , Doenças Hereditárias Autoinflamatórias/genética , Doenças Hereditárias Autoinflamatórias/fisiopatologia , Humanos , Inflamação , Linfadenite/genética , Deficiência de Mevalonato Quinase/diagnóstico , Faringite/genética , Faringite/cirurgia , Prognóstico , Recidiva , Estomatite Aftosa/genética , Síndrome , Tonsilectomia
11.
Medicine (Baltimore) ; 97(50): e13681, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30558077

RESUMO

BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most frequent form of oral ulceration, characterized by recurrent oral mucosal ulceration in an otherwise healthy individual. This study was designed to evaluate the efficacy and safety of Chinese herbal medicine for recurrent aphthous stomatitis. METHODS: Five databases will be searched from inception to date, including PubMed, Cochrane Library, EMBASE,CNKI, and CBM. The researchers will comprehensively screen clinical randomized trials of Chinese herbal medicine for recurrent aphthous stomatitis. The review will be conducted by 2 independent authors without time and language limitation. The risk of bias will be assessed by the Cochrane risk of bias tool. RESULTS: Ethical approval is not required because this study is based on published papers. After peer-review, the study will be disseminated in scientific journals and conferences. CONCLUSION: This systematic review will provide evidence for the efficacy and safety of Chinese medicine for recurrent aphthous stomatitis. PROSPERO REGISTRATION: CRD42018111955.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Úlceras Orais/tratamento farmacológico , Estomatite Aftosa/tratamento farmacológico , Humanos , Avaliação de Resultados (Cuidados de Saúde) , Ensaios Clínicos Controlados Aleatórios como Assunto , Recidiva , Resultado do Tratamento
12.
Rev. Soc. Odontol. La Plata ; 28(56): 19-22, dic. 2018. graf
Artigo em Espanhol | LILACS | ID: biblio-980852

RESUMO

La estomatitis aftosa recurrente es una patología que afecta la mucosa oral, se observa frecuentemente en niños y adolescentes. Objetivos: identificar las causas más frecuentes que coincidan con la aparición de aftas en niños y adolescentes, analizar si la alimentación presenta algún tipo de relación, evaluar la presencia de patologías sistémicas concomitantes y analizar el factor predisponente familiar. Material y método: Se realizó una encuesta de carácter anónimo en diferentes centros odontológicos públicos y privados de la ciudad de La Plata, a niños y adolescentes hasta 15 años de edad. Resultados: La población estudiada fueron niños y adolescentes hasta 15 años de edad. El 30 % manifestó sufrir aftas frecuentemente. El 91% de este grupo, lo asoció a situaciones de estrés (deporte competitivo y época de exámenes) y en menor medida a la época del año, período invernal. Afirmaron tener una dieta variada y consumir jugos artificiales con frecuencia. Se observó una alta incidencia de estomatitis aftosa recurrente en otros integrantes de la familia. Conclusión: La manifestación de estomatitis aftosa recurrente en la población estudiada coincide con situaciones de estrés. Se identificó un alto porcentaje de incidencia familiar, en padres, madres y hermanos (AU)


Recurrent aphthous stomatitis is a pathology which affects the oral mucosa and is frequently observed in children and adolescents. Purpose. To identify and analyze the most frequent factors which coincide with the development of aphthous stomatitis in children and adolescents. These factors include dietary habits, concomitant systemic diseases and family background as a predisposing factor. Materials and methods. An anonymous survey was conducted among children and adolescents in various public and private dental clinics from the city of La Plata. Results. The study population were children and adolescents up to 15 years. Thirty percent of patients reported a high frequency of ulcers. 91 % reported having ulcers under stressful situations (sports and exams) and to a lesser extent, during winter season. The patients claimed having a balanced diet and consuming artificial juices frequently. A high incidence of recurrent aphthous stomatitis was observed in other members of the family. Conclusion. The development of recurrent aphthous stomatitis in the studied population coincides with stressful situations. A high percentage of hereditary incidence was identified in parents and siblings (AU)


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Recidiva , Estomatite Aftosa , Estresse Psicológico , Argentina , Inquéritos Epidemiológicos , Estudo Observacional
13.
BMJ Case Rep ; 11(1)2018 Dec 07.
Artigo em Inglês | MEDLINE | ID: mdl-30567204

RESUMO

A 58-year-old man with a history of recurrent aphthous ulcers since childhood was admitted to the hospital with acute neurological decline characterised by loss of motor dexterity, dysarthria, dysphagia and unsteady gait. MRI brain was significant for symmetrical hyperintense T2 fluid attenuated inversion recovery (FLAIR) in the corticospinal tracts, including parts of the pons and the mesodiencephalic junction. Though initial concern was for neuro-Behçet's disease, brain biopsy ultimately revealed a diagnosis of astrocytoma. This report demonstrates a mimic of neuro-Behçet's disease and the importance of confirming the correct diagnosis prior to initiating therapy.


Assuntos
Astrocitoma/diagnóstico , Síndrome de Behçet/diagnóstico , Neoplasias do Tronco Encefálico/diagnóstico , Astrocitoma/diagnóstico por imagem , Astrocitoma/radioterapia , Biópsia , Encéfalo/diagnóstico por imagem , Neoplasias do Tronco Encefálico/diagnóstico por imagem , Neoplasias do Tronco Encefálico/radioterapia , Diagnóstico Diferencial , Evolução Fatal , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Recidiva , Estomatite Aftosa/etiologia
14.
Pan Afr Med J ; 30: 205, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30574224

RESUMO

Apthous ulcers, commonly referred to as canker sores, are the most common ulcerative lesions of the oral mucosa. These are usually painful and are associated with redness and occasional bleeding from the affected area(s). Low Level Laser Therapy (LLLT) has shown excellent results in relieving the pain and complete remission of the oral ulcers. Through a clinical case, we report two locations of oral ulcers treated successfully with diode laser.


Assuntos
Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Estomatite Aftosa/radioterapia , Adulto , Feminino , Humanos , Recidiva , Estomatite Aftosa/patologia , Resultado do Tratamento
16.
Pediatr Rheumatol Online J ; 16(1): 60, 2018 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-30241480

RESUMO

BACKGROUND: Diagnosis of Periodic Fever, Aphthous stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) syndrome is currently based on the modified Marshall's criteria, but no validated evidence based classification criteria for PFAPA has been established so far. METHODS: A multistep process, based on the Delphi and Nominal Group Technique was conducted. After 2 rounds of e-mail Delphi survey involving 21 experts in autoinflammation we obtained a list of variables that were discussed in an International Consensus Conference. Variables reaching the 80% of consensus between participants were included in the new classification criteria. In the second phase the new classification criteria and the modified Marshall's criteria were applied on a cohort of 80 pediatric PFAPA patients to compare their performance. RESULTS: The Delphi Survey was sent to 22 participants, 21 accepted to participate. Thirty variables were obtained from the survey and have been discussed at the Consensus Conference. Through the Nominal Group Technique we obtained a new set of classification criteria. These criteria were more restrictive in respect to the modified Marshall's criteria when applied on our cohort of patients. CONCLUSION: Our work led us to identify a new set of classification criteria for PFAPA syndrome, but they resulted to be too restrictive to be applied in daily clinical practice for the diagnosis of PFAPA.


Assuntos
Doenças Hereditárias Autoinflamatórias/diagnóstico , Consenso , Técnica Delfos , Diagnóstico Diferencial , Febre/complicações , Doenças Hereditárias Autoinflamatórias/classificação , Humanos , Linfadenite/complicações , Faringite/complicações , Estomatite Aftosa/complicações , Síndrome
17.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 43(7): 779-783, 2018 Jul 28.
Artigo em Chinês | MEDLINE | ID: mdl-30124215

RESUMO

OBJECTIVE: To analyze the incidence and distribution of oral mucosal diseases in Hunan Province and provide reference for prevention and treatment.
 Methods: The clinical data for all patients, who were treated in Xiangya Hospital of Central South University from April 2013 to March 2017, were collected. After screening, weighing and classifying, sex and age distribution for the disease was analyzed.
 Results: The female with the age between 40 to 49 were in the majority among 21 972 patients. The ratio between men to women was 1:1.05. According to the classification of diseases, the most common diseases were as follows: recurrent aphthous ulcer (27.17%), burning mouth syndrome (15.72%), oral submucous fibrosis (14.75%), oral lichen planus (10.38%), oral leukoplakia (4.21%), traumatic ulceration (4.14%), chronic cheilitis (3.47%), oral fungal infection (3.26%), and atrophic glossitis (2.74%). Recurrent oral ulcer (28.65%), burning mouth syndrome (23.70%) and oral lichen planus (13.31%) were the most common 3 kinds of oral mucosal diseases during females in Hunan. Oral submucous fibrosis was the most common oral mucosal disease among males in Hunan (28.56%).
 Conclusion: Recurrent oral ulcer, burning mouth syndrome and oral lichen planus are very popular in women in Hunan Province, and oral submucous fibrosis is the most common disease in male in this region. It shows a high trend of incidence in the surrounding provinces.


Assuntos
Doenças da Boca/epidemiologia , Adulto , Distribuição por Idade , Síndrome da Ardência Bucal/epidemiologia , China/epidemiologia , Feminino , Fibrose , Humanos , Incidência , Leucoplasia Oral/epidemiologia , Líquen Plano Bucal/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/terapia , Mucosa Bucal/patologia , Fibrose Oral Submucosa , Úlceras Orais/epidemiologia , Distribuição por Sexo , Estomatite Aftosa/epidemiologia
18.
Int J Pediatr Otorhinolaryngol ; 110: 100-104, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29859567

RESUMO

INTRODUCTION: PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) is the most frequent non-infectious cause of high fever observed among the European child population. While its cause is still not yet fully identified, PFAPA patients were previously shown to have altered tonsillar microbiome composition. Our study hypothesized that this is associated with a change in antimicrobial peptide (AMP) expression levels, as in the case of Crohn's disease which is another autoinflammatory disorder. METHODS AND MATERIALS: The tonsil specimens were isolated from seven patients with PFAPA syndrome, and six patients with group A beta-hemolytic streptococcal (GAßHS) recurrent tonsillitis. Tonsillar expression levels of human beta-defensin 1-2, cathelicidin, ribonuclease-7, and liver expressed antimicrobial peptide-1 were monitored by immunohistochemistry (IHC). Expression levels were scored using semi-quantitative analysis method and were statistically analyzed by Two-Way Repeated Measures Analysis of Variance test. RESULTS: Our results showed no significant difference in AMP expression levels between PFAPA and GAßHS patients. Immunolocalization of human beta-defensin 1 was different between the two groups; expressed at higher levels on tonsil surface epithelium (SE) than lymphoid interior (LI) in PFAPA patient group, while this was not evident in GAßHS patients group. CONCLUSIONS: Our results suggest that, PFAPA patients may be associated with altered AMP expression as in other autoinflammatory diseases. Future studies with subjects without any inflammatory condition are required for more precise conclusions.


Assuntos
Peptídeos Catiônicos Antimicrobianos/metabolismo , Febre/metabolismo , Linfadenite/metabolismo , Tonsila Palatina/metabolismo , Faringite/metabolismo , Estomatite Aftosa/metabolismo , Tonsilite/metabolismo , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pescoço , Ribonucleases/metabolismo , Streptococcus pyogenes , Síndrome , Tonsilite/microbiologia , beta-Defensinas/metabolismo
19.
An Bras Dermatol ; 93(3): 341-346, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29924245

RESUMO

BACKGROUND: Recurrent aphthous ulcerations are common benign ulcerated lesions on the mouth, whose etiology is poorly understood, with controversial treatment and difficult to control in clinical practice. OBJECTIVE: To evaluate the cases of recurrent aphthous ulcerations with a focus on treatment, diagnosis and etiology. METHODS: This is a retrospective study of the cases of the Oral Diagnosis service of the Rio Grande do Norte Federal University in Natal/RN. Data such as sex, age, race, location, smoking habits, types of treatment, relapsing episodes, laboratory test results and clinical characteristics were collected. The associations between the variables were analyzed using the Pearson Chi-square test (p <0.05). RESULTS: A total of 4895 patients were seen in the service over a period of 11 years. Of these, 161 (3.3%) had complaints of oral aphthous ulcerations, of which 76 (47.2%) were diagnosed as suffering from recurrent aphthous ulcerations and 68 (42.2%) with clinical information necessary for evaluation. The tongue was the most affected anatomical region, with 27 individuals (39.7%), followed by the buccal mucosa, with 22 cases (32.3%). STUDY LIMITATIONS: Retrospective study with data from medical records. CONCLUSION: Dental surgeons, dermatologists and otorhinolaryngologists are the main responsible for the first contact with patients with this disease and should be attentive to the clinical aspects and treat each patient in an individualized way, since the therapy is palliative, its diagnosis is by exclusion and its etiology is unknown.


Assuntos
Estomatite Aftosa/diagnóstico , Estomatite Aftosa/terapia , Adulto , Brasil/epidemiologia , Deficiências Nutricionais/complicações , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Prevalência , Recidiva , Estudos Retrospectivos , Fumar/efeitos adversos , Estomatite Aftosa/epidemiologia , Estomatite Aftosa/etiologia
20.
Gac Med Mex ; 154(2): 165-171, 2018.
Artigo em Espanhol | MEDLINE | ID: mdl-29733067

RESUMO

Introduction: Recurrent aphthous stomatitis (RAS) affects approximately 20% of the general population. Its etiology is still unknown. Objective: To analyze this entity's clinical features. Method: Data such as age, gender, family history of RAS, age at first episode onset, prodromal symptoms, number, size, morphology and localization of lesions, RAS clinical form, annual rate of recurrence, predisposing factors, symptoms and time for symptoms and lesions disappearance were assessed in 200 patients with RAS. Results: Patients had RAS minor forms. Main clinical characteristics were family history of RAS (89%), first episode at ≥ 10 years of age (69%), prodromal symptoms (66%), one lesion per episode (63%), < 0.5 cm lesions (64%), rounded morphology (55%), localization at the tongue (27%), 3 recurrent episodes per year (36%), stress as predisposing factor (34%), symptom disappearance in 2 days (54%) and healing of lesions in 8 days (40%). Conclusion: Even when RAS is a common disorder of the oral mucosa, there is no curative treatment available. Therapeutic measures seek to reduce the pain and size of lesions, accelerate the time of recovery and decrease the rate of relapses.


Assuntos
Estomatite Aftosa/diagnóstico , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Adulto Jovem
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