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1.
Medicine (Baltimore) ; 98(37): e17174, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31517872

RESUMO

HIV-positive individuals encounter a number of negative life events (NLEs). This cross-sectional study aimed to evaluate the association between NLEs and major depressive disorder (MDD) among HIV-positive individuals in Guangdong, China, about which little is known.HIV-positive individuals were recruited from the Centers for Disease Prevention and Control of Guangzhou, Zhongshan, and Yangjiang from September 2007 to September 2008. Data on NLEs were collected using a questionnaire. The Structured Clinical Interview for DSM-IV-TR Axis I Disorders-Patient Edition (SCID-I/P) based on the DSM-IV criteria was used to diagnose MDD. Multiple logistic regression analyses were conducted to evaluate the association between NLEs and MDD.Among the 339 participants, 306 (90.27%) reported that one or more NLEs had ever occurred. Participants who reported NLEs that included HIV infection, financial problems, AIDS diagnosis, HIV/AIDS discrimination, conflict with spouse or lover, conflict with other family members, problems in childbearing, and conflict with nonfamily were at a higher risk of MDD. Participants who reported more NLEs in the last year had a higher risk of MDD (OR = 2.86, 95%CI: 1.76-4.65) than individuals who reported fewer NLEs. Individuals with higher chronic stress scores had a higher risk of MDD (OR = 4.36, 95%CI: 2.44-7.78) than individuals with lower chronic stress scores. However, acute stress was not associated with MDD.NLEs were common among HIV-positive individuals. MDD was associated with a greater number of NLEs and the increased chronic stress caused by the NLEs. Interventions should be tailored to those who reported NLEs to help reduce the risk of MDD and increase the quality of life among HIV-positive individuals.


Assuntos
Transtorno Depressivo Maior/complicações , Infecções por HIV/complicações , Infecções por HIV/psicologia , Adolescente , Adulto , China , Estudos Transversais , Transtorno Depressivo Maior/epidemiologia , Feminino , Infecções por HIV/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Estresse Psicológico/complicações , Estresse Psicológico/epidemiologia , Adulto Jovem
2.
Psychiatr Hung ; 34(2): 172-182, 2019.
Artigo em Húngaro | MEDLINE | ID: mdl-31417006

RESUMO

An increasing number of studies deal with the potential correspondence between suicidal behaviour and creativity nowadays. Psychobiographical analysis of the life of well known artists may help the better understanding of this phenomenon. In the present study predictive and protective factors of suicide are presented through the case of the well known suicidal poet and writer, Sylvia Plath. The most important predictive factors of suicide in her case are: affective disorder, comorbid anxiety disorder, prior attempt of suicide, and also her seriously affected personality, that mainly appears in her affective dependence. Her life events, both causes and effects of these, are also predisposing suicide. The early loss of her father, ambivalent relation with her mother and her marriage foredoomed to failure are the most significant of them. Although she used to write since her early childhood, the constant fluctuation of her psychological state had serious effect on her ability to write and also her motivation, both being an additional source of stress, due to her performance pressure. The fear of the acceptance of her works could also lay to increased amount of stress and anxiety on her sensitive personality. Her tragical life events, her psychiatric illness and her relentless templets towards herself could cause such a pressing stress, that neither creation, nor motherhood (the most important protective factor for women) could predominate. Neither moving to England, nor her last confessional book, "The Bell Jar" could cure her many kind of wounds, and these factors together lead to the suicide.


Assuntos
Criatividade , Transtornos do Humor/história , Transtornos do Humor/psicologia , Fatores de Proteção , Suicídio/história , Suicídio/psicologia , Transtornos de Ansiedade/complicações , Feminino , História do Século XX , Humanos , Transtornos do Humor/complicações , Mães/psicologia , Motivação , Fatores de Risco , Estresse Psicológico/complicações , Redação/história
3.
Life Sci ; 234: 116778, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31430454

RESUMO

AIMS: To clarify the role of the gut-brain axis in depression. MAIN METHODS: We used the iTRAQ technique to identify differential proteins in the intestine of the rat model of chronic unpredictable mild stress (CUMS)-induced depression. Significant differential proteins were subjected to Gene Ontology (GO) functional annotations and KEGG pathway enrichment analysis. Key proteins were validated at the mRNA and protein levels. The levels of cytokines in the intestine, serum and hypothalamus were examined by ELISA. HPLC-UV was used to detect the levels of amino acids. KEY FINDINGS: In the rat intestine, 349 differential proteins (209 downregulated, 140 upregulated) were identified. GO analysis indicated that "protein complex assembly" was the first-ranked biological process. SNARE complex components, including SNAP23, VAMP3 and VAMP8, were increased at the mRNA levels, while only VAMP3 and VAMP8 were also upregulated at the protein level. TNFα, IL6 and IL1ß were upregulated in the CUMS rat intestine, while TNFα was decreased in the serum and hypothalamus. IL1ß was decreased in the serum. "Protein digestion and absorption" was the most significantly enriched KEGG pathway, involving 5 differential proteins: SLC9A3, ANPEP, LAT1, ASCT2 and B0AT1. Glutamine, glycine and aspartic acid were perturbed in the CUMS rat intestine. SIGNIFICANCE: Our findings suggest that CUMS enhances the adaptive immune response in the intestine through ER-phagosome pathway mediated by SNARE complex and disturb absorption of amino acids. It advances our understanding of the role of gut-brain axis in depression and provides a potential therapeutic target for the disease.


Assuntos
Aminoácidos/análise , Citocinas/análise , Depressão/patologia , Mucosa Intestinal/metabolismo , Intestinos/patologia , Proteínas SNARE/análise , Aminoácidos/metabolismo , Animais , Citocinas/genética , Depressão/etiologia , Depressão/genética , Modelos Animais de Doenças , Regulação da Expressão Gênica , Absorção Intestinal , Masculino , Proteômica , Ratos , Ratos Sprague-Dawley , Proteínas SNARE/genética , Estresse Psicológico/complicações
5.
Medicine (Baltimore) ; 98(26): e15917, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31261498

RESUMO

Acute onset neurological symptoms evoked by traumatic, surgical, or emotional events in Wilson disease (WD) have never been reported and its clinical characteristics are unclear.We aimed to summarize the clinical characteristics of a special WD whose neurological symptoms acutely developed after traumatic, surgical, or emotional events.Retrospective pilot study.Thirty-one patients who had acute onset neurological symptom as an initial presentation of WD or a new presentation of hepatic WD after mild trauma, surgery, or emotional events were retrospectively studied. All patients were followed for half to 1 year after regular anti-copper treatment.The averaged latency for neurological symptom presentation was 2.79 ±â€Š1.21 hours. The most frequent neurological symptoms were tremor (74%) and basal ganglia (BG) lesions were detected on magnetic resonance imaging in all patients. Lesions in other regions were much less frequently detected. Neurological symptom score and its recovery after treatment were correlated with lesion location: BG area and BG plus other brain areas. Neurological symptoms improved in 21 patients who received timely anti-copper treatment but continued to deteriorate in 6 patients who did not accept regular anti-copper treatment for delayed diagnosis.A diagnosis of WD should be considered when adolescents or adults experience acute presentation of extrapyramidal systems after traumatic, surgical, or emotional stimulation. Timely anti-copper therapy usually gives rise to an excellent prognosis.


Assuntos
Emoções , Degeneração Hepatolenticular/epidemiologia , Degeneração Hepatolenticular/fisiopatologia , Complicações Pós-Operatórias/epidemiologia , Estresse Psicológico/complicações , Estresse Psicológico/epidemiologia , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Criança , Estudos Transversais , Feminino , Seguimentos , Degeneração Hepatolenticular/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudo de Prova de Conceito , Estudos Retrospectivos , Fatores de Tempo , Adulto Jovem
6.
Nat Commun ; 10(1): 2942, 2019 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-31270312

RESUMO

Depression and transient ischaemic attack represent the common psychological and neurological diseases, respectively, and are tightly associated. However, studies of depression-affected ischaemic attack have been limited to epidemiological evidences, and the neural circuits underlying depression-modulated ischaemic injury remain unknown. Here, we find that chronic social defeat stress (CSDS) and chronic footshock stress (CFS) exacerbate CA1 neuron loss and spatial learning/memory impairment after a short transient global ischaemia (TGI) attack in mice. Whole-brain mapping of direct outputs of locus coeruleus (LC)-tyrosine hydroxylase (TH, Th:) positive neurons reveals that LC-CA1 projections are decreased in CSDS or CFS mice. Furthermore, using designer receptors exclusively activated by designer drugs (DREADDs)-based chemogenetic tools, we determine that Th:LC-CA1 circuit is necessary and sufficient for depression-induced aggravated outcomes of TGI. Collectively, we suggest that Th:LC-CA1 pathway plays a crucial role in depression-induced TGI vulnerability and offers a potential intervention for preventing depression-related transient ischaemic attack.


Assuntos
Região CA1 Hipocampal/fisiopatologia , Isquemia/fisiopatologia , Locus Cerúleo/fisiopatologia , Estresse Psicológico/fisiopatologia , Animais , Humanos , Isquemia/complicações , Isquemia/psicologia , Masculino , Memória , Camundongos , Camundongos Endogâmicos C57BL , Neurônios/fisiologia , Aprendizagem Espacial , Estresse Psicológico/complicações , Estresse Psicológico/psicologia
7.
Medicine (Baltimore) ; 98(27): e16274, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31277153

RESUMO

This study aimed to investigate the recognition rate of psychological distress in general hospitals in China and to examine the main associated factors.Using a cross-sectional study design, the questionnaires were administered to a total of 1329 inpatients from a tertiary hospital. The Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item scale (GAD-7), the Patient Health Questionnaire (PHQ-15) and the Whiteley-7 (WI-7) were used to assess patients' mental health status. Two subjective questions were used to identify the awareness of psychological distress in patients and doctors.The frequency of psychological distress measured by the questionnaires was high in our sample (53.4%). However, the recognition rates of both patients (34.9%) and by doctors (39.1%) was low. The concordance rate between patients and doctors of whether the patient had psychological distress or not was extremely poor (Kappa = 0.089, P = .001). Factors associated with the poor concordance rate included patients' annual household income and clinically significant self-reported symptoms of anxiety and hypochondriasis.The recognition rate of psychological distress was underestimated and this may be related to a lack of awareness of mental disturbances and patients' low annual household income.


Assuntos
Ansiedade/epidemiologia , Hospitais Gerais/estatística & dados numéricos , Médicos/psicologia , Qualidade de Vida , Estresse Psicológico/epidemiologia , Carga de Trabalho/psicologia , Adulto , Idoso , Ansiedade/etiologia , Ansiedade/psicologia , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Escalas de Graduação Psiquiátrica , Índice de Gravidade de Doença , Fatores Socioeconômicos , Estresse Psicológico/complicações , Inquéritos e Questionários
8.
Rev Assoc Med Bras (1992) ; 65(6): 830-833, 2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31340312

RESUMO

OBJECTIVE: Even though stress has been long known as a provocative factor for Graves' disease, its relationship with Hashimoto's thyroiditis is more controversial. Studies on this topic are scanty. This paper aims to report a case of stress-induced Hashitoxicosis. RESULTS: Here we report a case of Hashitoxicosis induced by a psychological stressful event in a 28-year-old woman with Hashimoto's thyroiditis. She had remained stably euthyroid for 12 years. She was first observed in April 2016, while euthyroid. She came back after 11 months because of fatigue and palpitations, in the absence of neck pain. Thyroid function tests revealed moderate thyrotoxicosis (undetectable TSH; FT4 36.94 pmol/L, normal values 9.0-24.46; FT3 13.50 pmol/L, normal values 3.07-6.14) with negative TSH-receptor antibodies. In the previous three months, she had experienced a psychological stressful event. Inflammatory markers were negative, and the white cell count was normal. Thyroid ultrasound revealed a modest increase in vascularization. Transient subclinical hypothyroidism ensued after seven weeks and spontaneously recovered. On the last visit, the patient was still on euthyroidism. (TSH 1.01 mU/L; FT4 9.22 pmol/L; FT3 3.98 pmol/L). We also performed HLA serotyping and genotyping. CONCLUSION: This case demonstrates that, similarly to Graves' disease, Hashitoxicosis can also be triggered by stressful life events.


Assuntos
Antígenos HLA/genética , Doença de Hashimoto/psicologia , Estresse Psicológico/complicações , Adolescente , Feminino , Genótipo , Doença de Hashimoto/genética , Humanos , Sorogrupo , Estresse Psicológico/genética , Tireotropina/sangue , Tiroxina/sangue
9.
Int J Behav Med ; 26(4): 352-364, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31218559

RESUMO

BACKGROUND: Although the deleterious impact of psychological distress on patients with coronary heart disease (CHD) is recognized, few studies have examined the influence of change in psychological distress on health outcomes over time. This study investigated whether three common manifestations of distress (depression, anxiety, and perceived stress) and their changes predicted the decline in physical functioning in CHD patients over 12 months. In addition, perceived social support was examined as a buffer of psychological distress or a direct predictor of physical functioning. METHODS: Participants were 255 CHD patients with a mean age of 63 (SD = 8.65) years, including 208 men and 47 women. Psychological distress and physical functioning were assessed at baseline, 6 months and 12 months. Hierarchical regression analyses were conducted to examine the influences of psychological factors on physical functioning over 12 months. All models were adjusted for baseline physical functioning, age, gender, marital status, education, BMI, and length of participation at a wellness center. RESULTS: For each psychological distress variable (depression, anxiety, or perceived stress), both the baseline (ßs = - 0.19 to - 0.32, ps = 0.008 to < 0.001) and its respective change over time (ßs = - 0.17 to - 0.38, ps = 0.020 to < 0.001) independently and significantly predicted greater decline in physical functioning at 6 and 12 months, after adjusting for covariates. Perceived social support predicted greater improvement in physical functioning at 12 months (ß = 0.13, p = 0.050), but it did not buffer impact of psychological distress. CONCLUSIONS: Findings underscore the importance of monitoring various forms of psychological distress continuously over time for CHD patients.


Assuntos
Ansiedade/fisiopatologia , Doença das Coronárias/psicologia , Depressão/fisiopatologia , Desempenho Físico Funcional , Estresse Psicológico/fisiopatologia , Idoso , Ansiedade/complicações , Ansiedade/psicologia , Doença das Coronárias/fisiopatologia , Depressão/complicações , Depressão/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Apoio Social , Estresse Psicológico/complicações , Estresse Psicológico/psicologia , Fatores de Tempo
10.
Internist (Berl) ; 60(6): 638-643, 2019 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-31076796

RESUMO

People with rare diseases have a very high rate of mental and social stress. This results in specific tasks and problems in the psychosomatic care of patients. On the one hand, the physical and/or psychological symptoms of an undetected rare organic disease can be misdiagnosed as a psychosomatic disease, and the affected persons possibly receive psychotherapy that is not causally effective. On the other hand, mental diseases that require treatment can arise as a result of the effects of a rare disease. These should be diagnosed as such and treated with psychotherapy. If, in individual cases, both symptoms of a rare disease and symptoms of a psychosomatic disorder in the sense of comorbidity are present, neither one nor the other diagnosis should lead to a hasty termination of diagnostic efforts. Otherwise, misalignments can easily occur and the further diagnostic and therapeutic process can be permanently disturbed. Interdisciplinary team care interventions should therefore be developed further.


Assuntos
Transtornos Psicofisiológicos , Medicina Psicossomática , Doenças Raras , Estresse Psicológico/complicações , Humanos , Transtornos Mentais/terapia , Equipe de Assistência ao Paciente , Transtornos Psicofisiológicos/classificação , Transtornos Psicofisiológicos/diagnóstico , Transtornos Psicofisiológicos/terapia , Psicoterapia , Psicotrópicos/uso terapêutico , Doenças Raras/diagnóstico , Doenças Raras/terapia
11.
Medicine (Baltimore) ; 98(20): e15416, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31096437

RESUMO

BACKGROUND: Psychological stress is a ubiquitous subjectively negative emotional experience, but excessive psychological stress has adverse effects on the happiness in our lives and physical and mental health, and may cause many health problems. Studies have found that probiotics have a certain role in alleviating negative emotions, reducing abnormal behaviors, improving cognitive function, and also showing the great potential of probiotics in relieving psychological stress. At present, many clinical trials have been carried out to intervene in populations with psychological stress with probiotic supplements, but there still lack of targeted systematic review and meta-analysis. METHODS AND ANALYSIS: The Cochrane Central Register of Controlled Trials, Embase, MEDLINE, Psycoinfo, Cumulative Index to Nursing and Allied Health Literature will be searched to obtain the eligible randomized controlled trials published up to March 1, 2019. Meanwhile, the references to relevant publications will also be reviewed to identify other studies, and will re-search before finial summary for analysis. EndNote X7 will be used as a document manager for duplicate checking and screening of literature. The risk of bias will be assessed and the date of included studies will be analyzed by Revman V5.3.5. RESULTS: The primary outcome will be subjective stress level, general mild psychiatric symptoms of participants. The secondary outcome will be cortisol level and adverse effects likely to be related to treatment. CONCLUSION: The systematic review and meta-analysis will provide evidence to assess the efficacy and safety of probiotics in relieving psychological stress. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019122930.


Assuntos
Probióticos/efeitos adversos , Probióticos/uso terapêutico , Estresse Psicológico/tratamento farmacológico , Cognição/efeitos dos fármacos , Suplementos Nutricionais/efeitos adversos , Emoções/efeitos dos fármacos , Feminino , Humanos , Hidrocortisona/sangue , Masculino , Avaliação de Resultados (Cuidados de Saúde) , Probióticos/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto , Estresse Psicológico/complicações , Estresse Psicológico/psicologia , Resultado do Tratamento
12.
Rev Bras Epidemiol ; 22: e190038, 2019.
Artigo em Português, Inglês | MEDLINE | ID: mdl-31038571

RESUMO

OBJECTIVE: To evaluate the prevalence of sleep bruxism, as well as its principal signs and symptoms, in the city of Rio Grande. Evaluate the association of sleep bruxism with gender, age, education and psychological stress. METHOD: The study was cross-sectional type. A representative sample of the population (1280 people residing in the urban area of the city aged greater than or equal to 18 years old) were interviewed. The evaluation of sleep bruxism was by mean of questionnaire based on diagnostic criteria of the International Classification of Sleep Disorders. RESULTS: The prevalence of sleep bruxism found in the population was 8,1% (confidence interval of 95% - 95%CI - 6,6 - 9,5). Among the signs and symptoms of dysfunction used for the diagnosis of sleep bruxism, tooth wear (70,3%) and pain in masticatory muscles (44,5%) were the most frequently reported by people who report teeth grinding during sleep. There was no significant difference in the prevalence of sleep bruxism between sexes. People older than 40 had a higher prevalence of sleep bruxism. The dysfunction was associated with a higher level of education (prevalence ratio - PR = 1.92; 95%CI 1,35 - 2,72) and psychological stress (PR 1,76; 95%CI 1,11 - 2,81). CONCLUSION: There was a significant prevalence of sleep bruxism in the general population, causing various damages to the Stomatognathic system. The psychological stress is a risk factor for this dysfunction.


Assuntos
Bruxismo do Sono/epidemiologia , Adolescente , Adulto , Fatores Etários , Brasil/epidemiologia , Estudos Transversais , Escolaridade , Feminino , Humanos , Masculino , Prevalência , Análise de Regressão , Fatores de Risco , Fatores Sexuais , Bruxismo do Sono/etiologia , Bruxismo do Sono/psicologia , Estresse Psicológico/complicações , Inquéritos e Questionários , Adulto Jovem
13.
J Consult Clin Psychol ; 87(7): 645-656, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31008636

RESUMO

OBJECTIVE: Distress tolerance (DT), the ability to withstand aversive internal states, represents an important risk factor for substance use relapse and a potential treatment target. Neurobiological research in substance using populations suggests that continued substance use could erode DT, whereas abstinence could bolster it. The current study characterized trajectories of behavioral and self-reported indices of DT and examined the prospective effect of substance use on DT trajectories among those seeking treatment for substance use. METHOD: Individuals (N = 263, Mage = 42.68, SD = 11.8, 70.7% male, 94.7% African American) in residential substance use treatment completed subjective (Distress Tolerance Scale) and behavioral (Mirror Tracing Persistence Task-computerized version) DT measures, as well as report of daily substance use (timeline follow-back) over 5 assessment time-points from pretreatment to 12 months posttreatment. Latent curve modeling estimated DT trajectories and their associations with substance use behavior, including abstinence duration (days until first use) and substance use frequency (percentage of substance use days between assessments). RESULTS: Self-reported and behavioral DT indicators both exhibited positive, nonlinear change over time (standardized slope parameter estimates: Distress Tolerance Scale ß = 0.61, p < .01; Mirror Tracing Persistence Task ß = 0.34, p < .01). Abstinence duration was associated with greater improvement in behavioral (ß = .20, p = .03) DT specifically. Frequency of use was statistically significantly associated with attenuated behavioral DT at 6-month (ß = -.12, p = .03) and 12-month follow-ups (ß = -.08, p = .045). CONCLUSIONS: DT appears to improve appreciably posttreatment, and return to substance use may shape the degree of this improvement. Collectively, these findings support the conceptualization of DT as a malleable treatment target and emphasize the benefit of abstinence on improvement in DT. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Assuntos
Afeto , Estresse Psicológico/psicologia , Transtornos Relacionados ao Uso de Substâncias/terapia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Autorrelato , Estresse Psicológico/complicações , Transtornos Relacionados ao Uso de Substâncias/complicações , Transtornos Relacionados ao Uso de Substâncias/psicologia
14.
Fortschr Neurol Psychiatr ; 87(7): 367-374, 2019 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-30970385

RESUMO

AIM: Stress conditions in patients with intellectual disabilities and psychiatric disorders are among all factors the most disabling in their quality of life. We aimed to develop a self-rating and third-person rating instrument verifying the effect of psychiatric and psychotherapeutic treatments in these patients. METHODS: First, we asked 150 caregivers of residential facility for patients with intellectual disabilities and psychiatric disorders to define 20 words, which describe stress conditions most accurately. Secondly, out of the list of collected words, two independent observers (neurologist, Germanist) defined subgroups, to which the words could be referred. Out of the most frequent subgroups, a questionnaire was developed in order to measure the expression of a target symptom. RESULTS: Out of 150 surveyed persons only 40 caregivers participated in the study with resulting 680 words defining stress condition in mentally disabled patients. Out of these, 31 words were excluded by observer A and 30 words by observer B, because according to their assessment, the words did not correctly cover the term 'stress condition'. Out of the remaining words, 13 subgroups were worked out. Exclusion of subgroups with less than 15 words in the development of the questionnaire resulted in following categories: (1) auto-aggression; (2) externalized aggression; (3) verbal aggression (4) isolation; (5) (motoric) restlessness; (6) autonomic changes; (7) emotional changes; (8) behavioral changes. For self- and third-person rating, a Likert scale was introduced, for self-rating, answers were visually supported with symbols. CONCLUSIONS: The development of an instrument to measure stress conditions in these patients is important for the improvement of therapies. Such an instrument for the measurement of psychological, social or medical therapy effects allows disentangling efficient strategies improving the patients' quality of life, as the assessment can be quickly integrated during a hospital intervention.


Assuntos
Deficiência Intelectual/complicações , Deficiência Intelectual/psicologia , Transtornos Mentais/complicações , Transtornos Mentais/psicologia , Estresse Psicológico/complicações , Estresse Psicológico/psicologia , Inquéritos e Questionários , Agressão/psicologia , Comportamento , Cuidadores/psicologia , Emoções , Humanos , Qualidade de Vida , Autorrelato , Estresse Psicológico/diagnóstico
15.
BMJ Case Rep ; 12(4)2019 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-30948410

RESUMO

Takotsubo syndrome is an intriguing condition of often stress induced reversible cardiac dysfunction mimicking myocardial infarction, but without explanatory coronary obstructions. The pathogenesis of the syndrome is not yet fully understood, though altered sympathetic regulation or response to cardiac sympathetic stimuli is likely to be involved. We present a unique and clinically detailed report of identical twin sisters, who both developed Takotsubo syndrome in association to mental stress shortly after menopause, also covering a potential relapse of disease in one of the twins, supporting the theory of a genetic contribution to the development of the syndrome proposed by previous case reports and small genetic studies.


Assuntos
Predisposição Genética para Doença , Cardiomiopatia de Takotsubo/diagnóstico , Eletrocardiografia , Feminino , Humanos , Angiografia por Ressonância Magnética , Pessoa de Meia-Idade , Estresse Psicológico/complicações , Cardiomiopatia de Takotsubo/genética , Cardiomiopatia de Takotsubo/psicologia , Gêmeos Monozigóticos
16.
Eur J Pharmacol ; 852: 198-206, 2019 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-30935894

RESUMO

Stress-induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin-releasing factor (CRF) dependent and also mediated via proinflammatory cytokine in animal IBS model. Dehydroepiandrosterone sulfate (DHEA-S) is known to have anti-inflammatory properties by suppressing proinflammatory cytokine release. We hypothesized that DHEA-S improves stress-induced visceral changes and is beneficial for IBS treatment. We explored the effects of DHEA-S on lipopolysaccharide (LPS)- or repeated water avoidance stress (WAS)-induced visceral allodynia and increased colonic permeability (rat IBS models). The threshold of visceromotor response, i.e. abdominal muscle contractions induced by colonic balloon distention was electrophysiologically measured. Colonic permeability was estimated in vivo by quantifying the absorbed Evans blue in colonic tissue. DHEA-S abolished visceral allodynia and colonic hyperpermeability induced by LPS in a dose-dependent manner. It also blocked repeated WAS- or peripheral injection of CRF-induced visceral changes. These effects by DHEA-S in LPS model were reversed by bicuculline, a γ-aminobutyric acid (GABA)A receptor antagonist, NG-nitro-L-arginine methyl ester, a nitric oxide (NO) synthesis inhibitor, naloxone, an opioid receptor antagonist, or sulpiride, a dopamine D2 receptor antagonist. However, domperidone, a peripheral dopamine D2 receptor antagonist did not modify the effects. Peripheral injection of astressin2-B, a selective CRF receptor subtype 2 (CRF2) antagonist also reversed these effects. In conclusion, DHEA-S blocked stress-induced visceral changes via GABAA, NO, opioid, central dopamine D2 and peripheral CRF2 signaling. DHEA-S may be useful for IBS treating.


Assuntos
Colo/efeitos dos fármacos , Colo/metabolismo , Sulfato de Desidroepiandrosterona/farmacologia , Síndrome do Intestino Irritável/complicações , Dor Visceral/complicações , Dor Visceral/tratamento farmacológico , Animais , Citocinas/metabolismo , Sulfato de Desidroepiandrosterona/uso terapêutico , Síndrome do Intestino Irritável/metabolismo , Síndrome do Intestino Irritável/psicologia , Masculino , Permeabilidade/efeitos dos fármacos , Ratos , Ratos Sprague-Dawley , Estresse Psicológico/complicações
17.
Complement Ther Clin Pract ; 35: 18-21, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31003655

RESUMO

BACKGROUND: and purpose: The stress and systemic lupus erythematosus (SLE) are intertwined and affecting each other. This pilot study evaluated the mindfulness-based cognitive therapy (MBCT) in Korean patients with SLE. MATERIALS AND METHODS: The Korean version of the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Satisfaction with Life Scale (SWLS), and Perceived Stress Scale (PSS) were evaluated for the effect of the MBCT in 25 patients. RESULTS: The BDI-II, BAI, SWLS, and PSS before the MBCT were 24.2 ±â€¯10.6, 19.1 ±â€¯9.7, 14.7 ±â€¯6.5, and 20.4 ±â€¯3.8, respectively. Eighteen patients completed the MBCT. After the MBCT, BDI-II, BAI, and PSS improved to 17.4 ±â€¯13.0 (p < 0.01), 13.4 ±â€¯7.7 (p = 0.04), and 17.9 ±â€¯4.6 (p = 0.04), respectively. However, SWLS and SLE disease activity did not. CONCLUSION: The MBCT could reduce the anxiety, depression, and stress but not SLE disease activity.


Assuntos
Ansiedade/terapia , Depressão/terapia , Lúpus Eritematoso Sistêmico/psicologia , Atenção Plena/métodos , Estresse Psicológico/terapia , Adulto , Ansiedade/complicações , Transtornos de Ansiedade/complicações , Transtornos de Ansiedade/terapia , Terapia Cognitivo-Comportamental , Depressão/complicações , Transtorno Depressivo/complicações , Transtorno Depressivo/terapia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Masculino , Pessoa de Meia-Idade , Projetos Piloto , República da Coreia , Estresse Psicológico/complicações
18.
Saudi Med J ; 40(4): 372-378, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30957131

RESUMO

OBJECTIVES: To determine if there is a relationship between acute stress and either the onset or relapse of multiple sclerosis (MS) and to discover how different types of acute stressors may be involved. Methods:  This study was carried out in Saudi Arabia between September 2017 and June 2018 and involved King Fahad University Hospital in Eastern province, Arfa Multiple Sclerosis Society in the Central and Western province of Saudi Arabia. A cross-sectional descriptive study was performed using an Arabic self-constructed questionnaire consisted of 4 sections: 1) demographic data and time of diagnosis; 2) emotional/psychological stressors; 3) environmental/physical stressors; and 4) 4 specific stressors measuring their effect on the severity and recurrence of attacks. Results: A total of 370 patients participated in the study. Almost half of patients reported no effect of family problems on their disease, whereas the other reported that family problems have an impact on the onset or relapse of the disease. Majority of patients reported that work and social life stressors affect the recurrence of attacks. Cold weather showed no effect on MS; however, hot weather and physical activity increased the number of attacks. Continuous thinking about social stress and problems, mood swings, and sleep deprivation showed an impact on the severity and recurrence of attacks. Financial problems showed no effect.  Conclusion: Study indicates that an association exists between acute stress and relapse in MS but not the disease onset.


Assuntos
Esclerose Múltipla/epidemiologia , Esclerose Múltipla/etiologia , Estresse Fisiológico/fisiologia , Estresse Psicológico/complicações , Doença Aguda , Adolescente , Adulto , Estudos Transversais , Humanos , Pessoa de Meia-Idade , Prevalência , Recidiva , Fatores de Risco , Arábia Saudita/epidemiologia , Índice de Gravidade de Doença , Inquéritos e Questionários , Fatores de Tempo , Adulto Jovem
19.
Nutrients ; 11(4)2019 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-30979031

RESUMO

The gut dysbiosis by stressors such as immobilization deteriorates psychiatric disorders through microbiota-gut-brain axis activation. To understand whether probiotics could simultaneously alleviate anxiety/depression and colitis, we examined their effects on immobilization stress (IS)-induced anxiety/depression and colitis in mice. The probiotics Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 were isolated from healthy human feces. Mice with anxiety/depression and colitis were prepared by IS treatment. NK33 and NK98 potently suppressed NF-κB activation in lipopolysaccharide (LPS)-induced BV-2 cells. Treatment with NK33 and/or NK98, which were orally gavaged in mice before or after IS treatment, significantly suppressed the occurrence and development of anxiety/depression, infiltration of Iba1⁺ and LPS⁺/CD11b⁺ cells (activated microglia) into the hippocampus, and corticosterone, IL-6, and LPS levels in the blood. Furthermore, they induced hippocampal BDNF expression while NF-κB activation was suppressed. NK33 and/or NK98 treatments suppressed IS-induced colon shortening, myeloperoxidase activity, infiltration of CD11b⁺/CD11c⁺ cells, and IL-6 expression in the colon. Their treatments also suppressed the IS-induced fecal Proteobacteria population and excessive LPS production. They also induced BDNF expression in LPS-induced SH-SY5Y cells in vitro. In conclusion, NK33 and NK98 synergistically alleviated the occurrence and development of anxiety/depression and colitis through the regulation of gut immune responses and microbiota composition.


Assuntos
Ansiedade/terapia , Bifidobacterium adolescentis , Colite/terapia , Depressão/terapia , Lactobacillus reuteri , Estresse Psicológico/complicações , Animais , Ansiedade/prevenção & controle , Ansiedade/psicologia , Linhagem Celular , Colite/psicologia , Depressão/prevenção & controle , Depressão/psicologia , Disbiose/psicologia , Humanos , Lipopolissacarídeos/farmacologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Microglia , NF-kappa B/metabolismo , Neuroblastoma , Probióticos/administração & dosagem , Restrição Física , Estresse Psicológico/etiologia , Células Tumorais Cultivadas
20.
BMC Ophthalmol ; 19(1): 69, 2019 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-30849950

RESUMO

BACKGROUND: Stress-induced activation of the sympathetic nervous system leads to a cascade of metabolic reactions. Emotional stress is a more specific form of stress in which the stressor is a psychological response to a situation subjectively perceived as traumatic. Stress hormones can have a wide range of effects on the body, however, it is still unclear if and how it can affect ophthalmic physiology. This report presents a case of severe ocular hypertension in which emotional stress was the only cause elicited, and explores potential aggravating factors. CASE PRESENTATION: A 78-year-old, personality type A, lady with a history of pseudo-exfoliative glaucoma presented with an acute asymmetrical raise in intraocular pressure (IOP) immediately following a family breakdown. Her IOP had previously remained stable following a deep sclerectomy in the right eye and an Ex-PRESS shunt in the left eye. Her examination was entirely normal otherwise, with a patent filtration and diffuse bleb as confirmed with anterior segment OCT imaging. Near-normalisation of her IOP was observed within 24 h, concomitantly with the reduction of her stress levels. No other cause for the transient acute hypertensive episode were found. CONCLUSIONS: This case report suggests that acute emotional stress could severely affect IOP in patients suffering from glaucoma. This could be important when looking after glaucoma patients. It would also suggest that the personnality types, and the emotional and social context are more factors to take into account in glaucoma studies. These observations are based on a single case report and would need to be verified on a larger scale.


Assuntos
Glaucoma/fisiopatologia , Hipertensão Ocular/etiologia , Estresse Psicológico/complicações , Doença Aguda , Idoso , Feminino , Humanos , Hipertensão Ocular/psicologia
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