Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.815
Filtrar
1.
SAR QSAR Environ Res ; 32(3): 207-219, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33601989

RESUMO

In this article, we consider cross-validation of the quantitative structure-property relationship models for reactions and show that the conventional k-fold cross-validation (CV) procedure gives an 'optimistically' biased assessment of prediction performance. To address this issue, we suggest two strategies of model cross-validation, 'transformation-out' CV, and 'solvent-out' CV. Unlike the conventional k-fold cross-validation approach that does not consider the nature of objects, the proposed procedures provide an unbiased estimation of the predictive performance of the models for novel types of structural transformations in chemical reactions and reactions going under new conditions. Both the suggested strategies have been applied to predict the rate constants of bimolecular elimination and nucleophilic substitution reactions, and Diels-Alder cycloaddition. All suggested cross-validation methodologies and tutorial are implemented in the open-source software package CIMtools (https://github.com/cimm-kzn/CIMtools).


Assuntos
Modelos Químicos , Relação Quantitativa Estrutura-Atividade , Software , Estudos de Validação como Assunto
2.
Diabetes Res Clin Pract ; 172: 108629, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33347898

RESUMO

AIMS: The aim of this study was to develop a Diabetes Mellitus Treatment Adherence Scale (DMTAS) to fill the gap in the internationally accepted comprehensive scale. METHODS: An initial item pool for the Diabetes Mellitus Treatment Adherence Scale (DMTAS) was generated based on a review of the literature and an open-ended interview. An expert group screened this initial item pool using an item-level content validity index. Then, pilot testing with 116 participants was conducted. After removing redundant and cross-loading items by exploratory factor analysis, 630 subjects were recruited to evaluate the reliability and validity of DMTAS. Analyses included internal consistency, test-retest reliability, split-half reliability, construct validity, convergent validity, and discriminant validity analysis. RESULTS: The final DMTAS consisted of 19 items and six dimensions. The results of the exploratory factor analysis indicated that the variances of each factor explained were 23.07%, 12.28%, 9.50%, 8.25%, 7.85%, and 5.80%, and all six factors explained 66.75% of the variance in the 19 items. The items' factor loadings were all above 0.6. The results of the confirmatory factor analysis indicated that adequate fit indices (χ2 value to degrees of freedom = 3.62; root mean square error of approximation = 0.06; goodness-of-fit index = 0.92) were achieved. The Cronbach's alpha coefficient was 0.79, test-retest reliability was 0.73, and split-half reliability was 0.75. CONCLUSIONS: The DMTAS showed good validity and reliability to measure the out-of-hospital treatment adherence in patients with diabetes mellitus.


Assuntos
Diabetes Mellitus/terapia , Psicometria/métodos , Cooperação e Adesão ao Tratamento/estatística & dados numéricos , Feminino , Humanos , Masculino , Reprodutibilidade dos Testes , Inquéritos e Questionários , Estudos de Validação como Assunto
3.
Methods Mol Biol ; 2181: 253-267, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-32729085

RESUMO

MicroRNAs (miRNAs) are a class of ~22 nt noncoding RNAs playing essential roles in the post-transcriptional regulation of gene expression, cell proliferation, and cell differentiation and are often found deregulated in several diseases including cancer.The A-to-I RNA editing, mediated by ADAR enzymes, is a diffuse post-transcriptional mechanism that converts the genetically coded adenosine (A) into inosine (I) at the RNA level. Among different RNA targets, the ADAR enzymes can also edit miRNA precursors. Specifically, a single nucleotide change (A/I) lying within the mature miRNA can alter the miRNA binding specificity and redirect the edited miRNA to a different mRNA target. In several cancer types a consistent deregulation of A-to-I RNA editing machinery also involves important miRNAs (either oncomiRs or tumor-suppressor miRNAs). Herein we describe a combined in silico and experimental approach for the detection of edited miRNAs and the identification and validation of their target genes potentially involved in cancer progression or invasion.


Assuntos
MicroRNAs/genética , Neoplasias/genética , Oncogenes , Edição de RNA/fisiologia , Análise de Sequência de DNA/métodos , Adenosina/análise , Adenosina/genética , Animais , Carcinogênese/genética , Biologia Computacional/métodos , Humanos , Inosina/análise , Inosina/genética , MicroRNAs/química , Neoplasias/patologia , Estudos de Validação como Assunto
4.
Cir. plást. ibero-latinoam ; 46(4): 441-448, oct.-dic. 2020. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-198726

RESUMO

INTRODUCCIÓN Y OBJETIVO: La microtia es un problema estético que conlleva una afección psicosocial en el desarrollo del paciente. La reconstrucción auricular mediante injerto costal autólogo es el procedimiento más usado. Determinamos los resultados quirúrgicos en nuestro hospital y el impacto en la calidad de vida de los pacientes con microtia sometidos a reconstrucción auricular con cartílago costal autólogo. MATERIAL Y MÉTODO: Estudio observacional, descriptivo, transversal y prolectivo en pacientes con diagnóstico de microtia uni o bilateral 1 año después de la reconstrucción. Evaluamos el resultado quirúrgico mediante cuestionario desarrollado y publicado por la primera autora, calificando características de apariencia estética de la oreja. Evaluamos la calidad de vida del paciente mediante cuestionario Glasgow Benefit Inventory, versión validada al español, en mayores de 15 años; para pacientes pediátricos utilizamos cuestionario Glasgow's Children's Benefit Inventory, versión traducida y validada por traductor especializado. RESULTADOS: Recogimos 83 pacientes con edad de 8 a 46 años. En la evaluación quirúrgica 13 pacientes (15.6%) tuvieron un resultado excelente, 27 (32.5%) bueno, 29 (34.9%) regular y 14 malo (16.8%). En la evaluación de calidad de vida encontramos en la escala total puntuación positiva en 78 pacientes (93.9%) y negativa en 5 (6%). CONCLUSIONES: El estudio presenta un panorama objetivo de las expectativas del cirujano sobre satisfacción y bienestar del paciente. Si bien solo encontramos resultados buenos y excelentes en el 48%, al revisar la escala de satisfacción encontramos puntaciones positivas, con bienestar en casi el 94%. Es importante que los pacientes conozcan nuestra preocupación por saber el impacto de la intervención y que podamos retroalimentar nuestra práctica quirúrgica. Hasta donde sabemos, este es el primer estudio en México que evalúa ambos aspectos


BACKGROUND AND OBJECTIVE: Microtia is not only an aesthetic problem but involves patient psychosocial development. The gold standard for auricular reconstruction is autologous costal cartilage. Our aim is to evaluate surgical outcomes and impact in quality of life after auricular reconstruction with autologous costal cartilage in microtia patients at our hospital. METHODS: Observational, descriptive, cross an prolective study on patients with uni or bilateral microtia 1 year after auricular reconstruction procedure. Surgical outcome was evaluated with a method previously published by the first author evaluating auricular aesthetic characteristics. Quality of life was evaluated with Glasgow Benefit Inventory, validated in Spanish, for over 15 years old patients; for pediatric patients we used the Glasgow's Children's Benefit Inventory, in a validated translated version. RESULTS: The study group was composed by 83 patients from 8 to 46 years old. Surgical outcome were excellent in 13 cases (15.6%), good in 27 (32.5%), regular in 29 cases (34.9%) and bad in 14 (16.8%). Quality of life had a positive total score in 78 cases (93.9%) and negative in 5 (6%). CONCLUSIONS: The study allows us an objective overview of surgeon's expectations regarding patient satisfaction and well-being. Although we only found good and excellent results in 48% of the patients, when reviewing the satisfaction scale we found positive scores in almost 94%. It`s important that patients know our concern about the impact of our intervention and to provide feedback on our surgical practice. As far as we know, this is the first study in Mexico evaluating both aspects


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Microtia Congênita/diagnóstico , Microtia Congênita/cirurgia , Qualidade de Vida/psicologia , Procedimentos Cirúrgicos Reconstrutivos/métodos , México , Estudos Transversais , Escala de Resultado de Glasgow , Estudos de Validação como Assunto
7.
Ann Biol Clin (Paris) ; 78(5): 547-554, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33026349

RESUMO

Biochemical diagnosis of hereditary metabolic diseases requires the detection and simultaneous identification of a large number of compounds, hence the interest in metabolic profiles. Organic acid chromatography allows the identification of several hundred compounds and the quantification of the main molecules of interest. As part of the accreditation process for medical biology examinations according to standard NF EN ISO 15189, the group from the French society for inborn errors of metabolism (SFEIM) recommends an approach to accredit organic acid chromatography. Validation parameters and recommendations are discussed in this specific framework.


Assuntos
Ácidos/urina , Cromatografia Gasosa-Espectrometria de Massas/normas , Erros Inatos do Metabolismo/diagnóstico , Compostos Orgânicos/urina , Urinálise/normas , Acreditação , Ácidos/análise , Adulto , Bioquímica/métodos , Bioquímica/normas , Criança , Serviços de Laboratório Clínico/normas , Testes Diagnósticos de Rotina/métodos , Testes Diagnósticos de Rotina/normas , Feminino , Cromatografia Gasosa-Espectrometria de Massas/métodos , Humanos , Recém-Nascido , Compostos Orgânicos/análise , Fase Pré-Analítica/métodos , Fase Pré-Analítica/normas , Gravidez , Urinálise/métodos , Coleta de Urina/métodos , Coleta de Urina/normas , Estudos de Validação como Assunto
8.
PLoS One ; 15(10): e0239962, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33022026

RESUMO

Chronic urticaria causes a significant limitation to quality of life. In the literature, various studies can be found that have reviewed several clinical and laboratory markers, but none of these variables alone is sufficient to predict the patient's prognosis. In this study, we present a protocol to develop a prognostic model that can predict the clinical response of urticaria patients to antihistamines. This is a protocol for a bidirectional cohort study. Urticaria data will be routinely collected from a population of patients over 18 years old. A full multivariable logistic regression model will be fitted, following five steps: 1) Selection of predictive variables for the model; 2) Evaluation of the quality of the collected data and control of lost data; 3) Data statistical management; 4) Strategies to select the variables to include at the end of the model; 5) Evaluation of the performance of the different possible models (predictive accuracy) and selection of the best model. The performance and internal validation of the model will be assessed. Some clinical and paraclinical variables will be measured for further exploration.


Assuntos
Urticária Crônica/tratamento farmacológico , Antagonistas dos Receptores Histamínicos/uso terapêutico , Modelos Logísticos , Adolescente , Adulto , Urticária Crônica/epidemiologia , Estudos de Coortes , Feminino , Humanos , Masculino , Prognóstico , Estudos de Validação como Assunto , Adulto Jovem
9.
J Transl Med ; 18(1): 405, 2020 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-33087150

RESUMO

BACKGROUND: Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients. METHODS: A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled after the first cohort was accomplished, was used as a secondary validation dataset. The two cohorts were evaluated jointly in an exploratory multivariable logistic regression model to assess prognostic variables on survival. RESULTS: In the primary intention-to-treat (ITT) phase 2 population, 180/301 (59.8%) subjects received tocilizumab, and 67 deaths were observed overall. Lethality rates were equal to 18.4% (97.5% CI: 13.6-24.0, P = 0.52) and 22.4% (97.5% CI: 17.2-28.3, P < 0.001) at 14 and 30 days, respectively. Lethality rates were lower in the validation dataset, that included 920 patients. No signal of specific drug toxicity was reported. In the exploratory multivariable logistic regression analysis, older age and lower PaO2/FiO2 ratio negatively affected survival, while the concurrent use of steroids was associated with greater survival. A statistically significant interaction was found between tocilizumab and respiratory support, suggesting that tocilizumab might be more effective in patients not requiring mechanical respiratory support at baseline. CONCLUSIONS: Tocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory support at baseline. Registration EudraCT (2020-001110-38); clinicaltrials.gov (NCT04317092).


Assuntos
Anticorpos Monoclonais Humanizados/uso terapêutico , Betacoronavirus/efeitos dos fármacos , Infecções por Coronavirus/tratamento farmacológico , Pneumonia Viral/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus/imunologia , Estudos de Coortes , Infecções por Coronavirus/epidemiologia , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Mortalidade , Uso Off-Label , Pandemias , Pneumonia Viral/epidemiologia , Resultado do Tratamento , Estudos de Validação como Assunto
12.
PLoS One ; 15(9): e0238908, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32915901

RESUMO

BACKGROUND: The development of deep learning (DL) algorithms is a three-step process-training, tuning, and testing. Studies are inconsistent in the use of the term "validation", with some using it to refer to tuning and others testing, which hinders accurate delivery of information and may inadvertently exaggerate the performance of DL algorithms. We investigated the extent of inconsistency in usage of the term "validation" in studies on the accuracy of DL algorithms in providing diagnosis from medical imaging. METHODS AND FINDINGS: We analyzed the full texts of research papers cited in two recent systematic reviews. The papers were categorized according to whether the term "validation" was used to refer to tuning alone, both tuning and testing, or testing alone. We analyzed whether paper characteristics (i.e., journal category, field of study, year of print publication, journal impact factor [JIF], and nature of test data) were associated with the usage of the terminology using multivariable logistic regression analysis with generalized estimating equations. Of 201 papers published in 125 journals, 118 (58.7%), 9 (4.5%), and 74 (36.8%) used the term to refer to tuning alone, both tuning and testing, and testing alone, respectively. A weak association was noted between higher JIF and using the term to refer to testing (i.e., testing alone or both tuning and testing) instead of tuning alone (vs. JIF <5; JIF 5 to 10: adjusted odds ratio 2.11, P = 0.042; JIF >10: adjusted odds ratio 2.41, P = 0.089). Journal category, field of study, year of print publication, and nature of test data were not significantly associated with the terminology usage. CONCLUSIONS: Existing literature has a significant degree of inconsistency in using the term "validation" when referring to the steps in DL algorithm development. Efforts are needed to improve the accuracy and clarity in the terminology usage.


Assuntos
Algoritmos , Diagnóstico por Imagem/métodos , Aprendizado de Máquina , Publicações Periódicas como Assunto/normas , Humanos , Fator de Impacto de Revistas , Estudos de Validação como Assunto
13.
Aquichan ; 20(3): e2038, July-Sept. 2020. tab, graf
Artigo em Inglês | LILACS, BDENF - Enfermagem, COLNAL | ID: biblio-1130973

RESUMO

ABSTRACT Objective: This study aims to validate the Portuguese version of the Practice Environment Scale of the Nursing Work Index (PES-NWI) and assess construct validity through exploratory and confirmatory factor analyses. Materials and Methods: This cross-sectional study validates the psychometric properties of the PES-NWI in Portugal. Exploratory factorial analysis is used to analyze the psychometric properties of the PES-NWI in a sample of 5,075 Portuguese nurses; the data sample covers all geographic regions in the country. Confirmatory factor analysis is performed to confirm the model's data adequacy. Results: Factorial analysis explained 54.6 % of the variance and a five-dimension structure. The five factors identified were Nurse Participation in Hospital Affairs, Nurse Manager Ability, Leadership and Support of Nurses, Nursing Foundations for Quality of Care, Staffing and Resource Adequacy, and Nurse-Physician Relations. The confirmatory analysis showed that the five-factor model fit well with the data in the Portuguese context. Conclusion: In a Portuguese health context, the PES-NWI is a valid scale to access the nursing environment and improve working conditions.


RESUMEN Objetivo: este estudio tiene como objetivo validar la versión portuguesa de la escala del entorno de práctica del índice de trabajo de enfermería (PES-NWI, por sus siglas en inglés) y evaluar la validez de los constructos mediante análisis factorial exploratorio y confirmatorio. Materiales y métodos: el presente estudio transversal valida las propiedades psicométricas de la PES-NWI en Portugal. El análisis factorial exploratorio se utilizó para analizar las propiedades psicométricas de la PES-NWI en una muestra de 5 075 enfermeras portuguesas; la muestra de datos abarcaba todas las regiones geográficas del país. Se realizó un análisis factorial confirmatorio para corroborar la adecuación de los datos del modelo. Resultados: un análisis factorial explicó el 54.6 % de la varianza y una estructura de cinco dimensiones. Los cinco factores identificados fueron la participación de la enfermera en los asuntos hospitalarios; la capacidad del gerente de enfermería, el liderazgo y el apoyo de las enfermeras; los fundamentos de la enfermería para la calidad de la atención; la adecuación del personal y de los recursos y las relaciones entre la enfermera y el médico. El análisis confirmatorio mostró que el modelo de cinco factores se ajustaba bien a los datos en el contexto portugués. Conclusión: en el contexto de salud portugués, la PES-NWI es una escala válida para acceder al entorno de enfermería y mejorar las condiciones de trabajo.


RESUMO Objetivo: o objetivo deste estudo é validar a versão portuguesa da escala do ambiente de prática do índice de trabalho de enfermagem (PES-NWI, por sua sigla em inglês) e avaliar a validade dos constructos mediante análise fatorial exploratória e confirmatória. Materiais e métodos: este estudo transversal valida as propriedades psicométricas da PES-NWI em Portugal. A análise fatorial exploratória foi utilizada para analisar as propriedades psicométricas da PES-NWI em uma amostra de 5 075 enfermeiras portuguesas; a amostra de dados abrangia todas as regiões geográficas do país. Foi realizada uma análise fatorial confirmatória para corroborar a adequação dos dados do modelo. Resultados: uma análise fatorial explicou 54,6 % da variância e uma estrutura de cinco dimensões. Os cinco fatores identificados foram a participação da enfermeira nos assuntos hospitalares; a capacidade do gerente de enfermagem, a liderança e o apoio das enfermeiras; os fundamentos da enfermagem para a qualidade da atenção; a adequação do pessoal e dos recursos e das relações entre a enfermeira e o médico. A análise confirmatória mostrou que o modelo de cinco fatores se ajustava bem aos dados no contexto português. Conclusões: no contexto de saúde português, a PES-NWI é uma escala válida para acessar o ambiente de enfermagem e melhorar as condições de trabalho.


Assuntos
Humanos , Psicometria , Ambiente de Trabalho , Portugal , Inquéritos e Questionários , Enfermagem , Estudos de Validação como Assunto
14.
Health Qual Life Outcomes ; 18(1): 263, 2020 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-32746836

RESUMO

Duchenne muscular dystrophy (DMD) is an inherited X-linked neuromuscular disorder. A number of questionnaires are available to assess quality of life in DMD, but there are concerns about their validity. This systematic review aimed to appraise critically the content and structural validity of quality of life instruments for DMD. Five databases (EMBASE, MEDLINE, CINAHL, PsycINFO, and Cochrane Library) were searched, with supplementary searches in Google Scholar. We included articles with evidence on the content and/or structural validity of quality of life instruments in DMD, and/or instrument development. Evidence was evaluated against the Consensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. Fifty five articles featured a questionnaire assessing quality of life in DMD. Forty instruments were extracted and 26 underwent assessment. Forty-one articles contained evidence on content or structural validity (including 37 development papers). Most instruments demonstrated low quality evidence and unsatisfactory or inconsistent validity in DMD, with the majority not featuring direct validation studies in this population. Only KIDSCREEN received an adequate rating for instrument design and a satisfactory result for content validity based on its development, yet, like the majority of PROMs, the measure has not been directly validated for use in DMD. Further research is needed on the validity of quality of life instruments in DMD, including content and structural validity studies in this population.


Assuntos
Distrofia Muscular de Duchenne/psicologia , Qualidade de Vida , Inquéritos e Questionários/normas , Feminino , Humanos , Masculino , Estudos de Validação como Assunto
15.
Ann Biol Clin (Paris) ; 78(4): 454-460, 2020 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-32616472

RESUMO

Blood angiotensin-converting enzyme (ACE) assay is now realized by the determination of enzyme activity on synthetic substrate, mostly furylacryloyl-phenylalanyl-L-glycyl-L-glycine (FAPGG). The matrix can be serum or heparin-plasma, with or without a separator; the assay developed on serum or plasma is not adapted to other matrix such as cerebrospinal fluid where the ACE activity is much lower. This assay has been adapted on a number of automated biochemistry analyzers with the specifications of the supplier of reagents, sometimes with modification of volumes or times for analysis. Samples can be stored at +4̊C for at least for one week, freezing at -20̊C is possible but refreezing is not advised. The assay is linear from 10 to 200 UI/L. Fidelity is excellent after calibration of the assay. Accuracy can be calculated from IQA and EQA results, and the analytical uncertainty is between 2% and 5% in function of the serum ACE value. Usual values will be soon available from studies on age brackets and sex, because ACE activity seems to be more elevated in boys during adolescence. At signature, it is interesting to have medical information on the diagnosis of sarcoidosis or its treatment including ACE inhibitors as a proof of intake; we can give a commentary on elevation of serum ACE activity from other causes than sarcoidosis and the causes for low activities.


Assuntos
Análise Química do Sangue/métodos , Peptidil Dipeptidase A/análise , Peptidil Dipeptidase A/sangue , Biomarcadores/análise , Biomarcadores/sangue , Análise Química do Sangue/normas , Coleta de Amostras Sanguíneas/métodos , Coleta de Amostras Sanguíneas/normas , Granuloma/sangue , Granuloma/diagnóstico , Granuloma/terapia , Humanos , Monitorização Fisiológica/métodos , Monitorização Fisiológica/normas , Fase Pré-Analítica , Reprodutibilidade dos Testes , Sarcoidose/sangue , Sarcoidose/diagnóstico , Sarcoidose/terapia , Sensibilidade e Especificidade , Estudos de Validação como Assunto
16.
Br J Anaesth ; 125(4): 614-621, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32703550

RESUMO

BACKGROUND: The 15-item Quality of Recovery (QoR-15) scale is a validated patient-reported outcome questionnaire that measures the quality of postoperative recovery. This study aimed to validate a translated Korean version of QoR-15 (QoR-15K) in a broad range of surgical patients. METHODS: After Korean translation of the original English version of the QoR-15, we performed psychometric validation of the QoR-15K to evaluate the quality of recovery after surgery. The validity, reliability, responsiveness, and clinical feasibility of the QoR-15K were evaluated. A subgroup analysis in patients with video-assisted lung resection was performed. RESULTS: Among 193 patients, 188 (97.4%) completed the QoR-15K after surgery. We found good convergent validity between the postoperative QoR-15K and the global QoR visual analogue scale (ρ=0.61, P<0.001). The negative correlation between the QoR-15K score and the extent of surgery (ρ=-0.33, P<0.001), the duration of surgery (ρ=-0.33, P<0.001), and the severity of postoperative pain (ρ=-0.40, P<0.001) supported construct validity. The postoperative QoR-15K showed good internal consistency (Cronbach α=0.90), split-half reliability (0.81), and test-retest reliability (0.95; 95% confidence interval [CI], 0.94-0.96). The QoR-15K score decreased from 140 (preoperative, inter-quartile range [IQR] 128-146) to 100 (postoperative day 1, IQR 75-122), median difference -36.5 (95% CI, -41 to -32.5; P<0.0001). The QoR-15K indicated excellent responsiveness with Cliff's effect size -0.78 (95% CI, -0.84 to -0.71). Subgroup analysis yielded similar results. CONCLUSIONS: The QoR-15K is valid and has excellent reliability, a high degree of responsiveness, and clinical feasibility as a metric of quality of recovery in Korean surgical population. CLINICAL TRIAL REGISTRATION: NCT04169087.


Assuntos
Recuperação Pós-Cirúrgica Melhorada , Medidas de Resultados Relatados pelo Paciente , Inquéritos e Questionários , Idoso , Período de Recuperação da Anestesia , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , República da Coreia , Estudos de Validação como Assunto
17.
Tunis Med ; 98(5): 378-395, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32548841

RESUMO

OBJECTIVE: The objective of this literature review is to gather all the LFT norms available for the Tunisian population, as well as QDV questionnaires specific to chronic respiratory patients that have been validated in Tunisia. METHODS: This review included a literature search using the PubMed and Sciencedirect databases. The reference lists of the retrieved English/French articles were searched for any additional reference. Specific research has been carried out for each stage of the natural evolution of chronic diseases. For LFT used in the exploration of deficiency, the key-words were ("respiratory function test" OR "spirometry" OR "plethysmography" OR "exhaled fraction of oxide nitric" OR "lung diffusion" OR "peak nasal inspiratory flow" OR "Lung age") AND ("Tunisia" OR "North Africa") AND ("reference equation" OR "reference value" OR "standard reference"). For LFT used in the exploration of incapacity, the key-words were ("exercise test" OR "maximal oxygen uptake" OR "cardiorespiratory test" OR "six minute walk distance" OR "six-minute walk distance" OR "6-minute walk distance" OR "six-min walk distance" OR "6-min walk distance" OR "six minute walking distance" OR "six-minute walking distance" OR "6MWD") AND ("Tunisia" OR "North Africa") AND ("reference equation" OR "reference value" OR "standard reference"). For the QOL questionnaires used in pneumology, the key-words were: ("quality of life" OR "QOL") AND ("respiratory" OR "pulmonology") AND ("Tunisia" OR "North Africa"). RESULTS: As part of deficiency exploration, 11 Tunisian norms are available. As part of incapacity exploration, three Tunisian norms are available for the 6-minute walk test. Only one QOL questionnaire specific to chronic respiratory patients has been validated in Tunisia. CONCLUSION: Despite its richness, the Tunisian "bank" of norms for LFT and QOL questionnaires has yet to be enriched.


Assuntos
Doença Pulmonar Obstrutiva Crônica/diagnóstico , Qualidade de Vida , Testes de Função Respiratória/normas , Insuficiência Respiratória/diagnóstico , Inquéritos e Questionários/normas , Doença Crônica , Pessoas com Deficiência , Progressão da Doença , Teste de Esforço/métodos , Teste de Esforço/normas , Humanos , Doença Pulmonar Obstrutiva Crônica/patologia , Valores de Referência , Testes de Função Respiratória/métodos , Insuficiência Respiratória/patologia , Índice de Gravidade de Doença , Tunísia , Estudos de Validação como Assunto
18.
BMC Neurol ; 20(1): 245, 2020 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-32534583

RESUMO

BACKGROUND: Parkinson's Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. Here, the study protocol of the Dutch Parkinson Cohort (DUPARC) is described. DUPARC is a longitudinal cohort study aimed at deeply phenotyping de novo PD patients who are treatment-naïve at baseline, to discover and validate biomarkers for PD progression, subtypes and pathophysiology. METHODS/DESIGN: DUPARC is a prospective cohort study in which 150 de novo PD subjects will be recruited through a collaborative network of PD treating neurologists in the northern part of the Netherlands (Parkinson Platform Northern Netherlands, PPNN). Participants will receive follow-up assessments after 1 year and 3 years, with the intention of an extended follow-up with 3 year intervals. Subjects are extensively characterized to primarily assess objectives within three major domains of PD: cognition, gastrointestinal function and vision. This includes brain magnetic resonance imaging (MRI); brain cholinergic PET-imaging with fluoroethoxybenzovesamicol (FEOBV-PET); brain dopaminergic PET-imaging with fluorodopa (FDOPA-PET); detailed neuropsychological assessments, covering all cognitive domains; gut microbiome composition; intestinal wall permeability; optical coherence tomography (OCT); genotyping; motor and non-motor symptoms; overall clinical status and lifestyle factors, including a dietary assessment; storage of blood and feces for additional analyses of inflammation and metabolic parameters. Since the start of the inclusion, at the end of 2017, over 100 PD subjects with a confirmed dopaminergic deficit on FDOPA-PET have been included. DISCUSSION: DUPARC is the first study to combine data within, but not limited to, the non-motor domains of cognition, gastrointestinal function and vision in PD subjects over time. As a de novo PD cohort, with treatment naïve subjects at baseline, DUPARC provides a unique opportunity for biomarker discovery and validation without the possible confounding influences of dopaminergic medication. TRIAL REGISTRATION: NCT04180865; registered retrospectively, November 28th 2019.


Assuntos
Biomarcadores/análise , Progressão da Doença , Estudos Observacionais como Assunto , Doença de Parkinson , Idoso , Estudos de Coortes , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Países Baixos , Doença de Parkinson/complicações , Doença de Parkinson/fisiopatologia , Estudos Prospectivos , Estudos Retrospectivos , Estudos de Validação como Assunto
19.
Epilepsia ; 61(7): 1319-1335, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32474909

RESUMO

Our objective was to undertake a systematic review ascertaining the accuracy of using administrative healthcare data to identify epilepsy cases. We searched MEDLINE and Embase from 01/01/1975 to 03/07/2018 for studies evaluating the diagnostic accuracy of routinely collected healthcare data in identifying epilepsy cases. Any disease coding system in use since the International Classification of Diseases, Ninth Revision (ICD-9) was permissible. Two authors independently screened studies, extracted data, and quality-assessed studies. We assessed positive predictive value (PPV), sensitivity, negative predictive value (NPV), and specificity. The primary analysis was a narrative synthesis of review findings. Thirty studies were included, published between 1989 and 2018. Risks of bias were low, high, and unclear in 4, 14, and 12 studies, respectively. Coding systems included ICD-9, ICD-10, and Read Codes, with or without antiepileptic drugs (AEDs). PPVs included ranges of 5.2%-100% (Canada), 32.7%-96.0% (USA), 47.0%-100% (UK), and 37.0%-88.0% (Norway). Sensitivities included ranges of 22.2%-99.7% (Canada), 12.2%-97.3% (USA), and 79.0%-94.0% (UK). Nineteen studies contained at least one algorithm with a PPV >80%. Sixteen studies contained at least one algorithm with a sensitivity >80%. PPV was highest in algorithms consisting of disease codes (ICD-10 G40-41, ICD-9 345) in combination with one or more AEDs. The addition of symptom codes to this (ICD-10 R56; ICD-9 780.3, 780.39) lowered PPV. Sensitivity was highest in algorithms consisting of symptom codes with one or more AEDs. Although using AEDs alone achieved high sensitivities, the associated PPVs were low. Most NPVs and specificities were >90%. We conclude that it is reasonable to use administrative data to identify people with epilepsy (PWE) in epidemiological research. Studies prioritizing high PPVs should focus on combining disease codes with AEDs. Studies prioritizing high sensitivities should focus on combining symptom codes with AEDs. We caution against the use of AEDs alone to identify PWE.


Assuntos
Coleta de Dados/estatística & dados numéricos , Bases de Dados Factuais/estatística & dados numéricos , Assistência à Saúde/estatística & dados numéricos , Epilepsia/epidemiologia , Estudos de Validação como Assunto , Coleta de Dados/normas , Bases de Dados Factuais/normas , Assistência à Saúde/normas , Epilepsia/diagnóstico , Humanos
20.
Surgery ; 168(1): 173-177, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32448593

RESUMO

BACKGROUND: Multivariable prediction models combine patient data points to provide actionable estimates of outcomes. Prediction models for melanoma are important for guidance in the midst of the rising incidence and evolving treatment options. This study evaluates the quality of reporting of prediction models using the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) checklist. METHODS: We performed a systematic literature search to identify publications describing development and/or validation of melanoma prediction models. For each study, reviewers assessed compliance with 22 TRIPOD items. We also assessed a model's predictive ability (area under the curve) compared with TRIPOD adherence. RESULTS: We originally identified 67 articles, of which 27 met inclusion criteria. No study completely followed the TRIPOD checklist, and median overall adherence was 61%. Authors were least likely to report participant characteristics, title, and abstract in accordance with the TRIPOD checklist. Linear correlation between a model's area under the curve and TRIPOD checklist adherence was not statistically significant, r = -0.09 (P = .34). CONCLUSION: Current reporting of melanoma multivariable prediction models does not meet standards. Although there is room for improvement in how melanoma models are reported, our findings do not indicate a significant relationship between the model's performance and adherence to the TRIPOD checklist.


Assuntos
Melanoma , Modelos Estatísticos , Neoplasias Cutâneas , Humanos , Estudos de Validação como Assunto
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...