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1.
Zhongguo Ying Yong Sheng Li Xue Za Zhi ; 35(4): 376-380, 2019 Jul 28.
Artigo em Chinês | MEDLINE | ID: mdl-31701727

RESUMO

OBJECTIVE: To investigate whether salidroside (Sal) plays a part in protecting myocardial cell through reducing the myocardial ischemia and the apoptosis pathway of both death receptors and mitochondria in acute exhausted rats. METHODS: Male SD rats were randomly divided into 4 groups (n=6): control group(Con), acute exhaustive swimming group (EE), low-dose and high-dose Sal pre-treatment exhaustive swimming group (SLE, SHE). Rats were treated with Sal solution (15 or 30 mg/(kg·d)) or 0.9%NaCl (3 ml/(kg·d)) by intraperitoneal injection for 15 d, respectively. The Con group did not carry out swimming training. The next day after the end of intraperitoneal administration, the rats in EE, SLE and SHE group were forced to swim until they were exhausted followed the standard of Thomas. After the end of exhaustive exercise, the rats were anesthetized and the blood samples and hearts were collected immediately. The myocardial ischemia and hypoxia area and myocardial apoptosis index (AI) were also observed. Serum ischemia modified albumin (IMA), cardiac troponin I (cTnI), brain natriuretic peptide(BNP) and myocardial cell Bcl-2-associated X protein (Bax), B-cell lymphoma-2 (Bcl-2) were determined. The expressions of myocardial TNF receptor superfamily member 6 (Fas), cytochrome C (Cyto-c), aspartate proteolytic enzyme-3(Caspase-3), aspartate proteolytic enzyme-8(Caspase-8), and aspartate proteolytic enzyme-9(Caspase-9) were detected. RESULTS: Compared with the Con group, the myocardial ischemia and hypoxia area in EE group was increased significantly. The serum levels of IMA, cTnI and BNP, AI and Bax levels and cardiac Fas, Cyto-C, Caspase-3, Caspase-8 and Caspase-9 protein expressions of EE group were also increased significantly (P<0.01), while the protein expression of Bcl-2 in cardiac tissues was decreased significantly (P<0.01). Compared with the EE group, the myocardial ischemia and hypoxia area, serum levels of IMA, cTnI and BNP, AI and Bax levels, and the protein expressions of cardiac Fas, Cyto-C, Caspase-3, Caspase-8 and Caspase-9 in Sal group were all decreased significantly(P<0.01). while the protein expression of cardiac Bcl-2 in Sal group were increased significantly (P<0.01). CONCLUSION: Sal plays a role in protecting myocardial cell through reducing the myocardial ischemia and inhibiting myocardial cell apoptosis in exhaustive exercise rats. The mechanism of reducing myocardial cell apoptosis may be related to inhibiting the expressions of Fas, Cyto-C, Caspase-3, Caspase-8, Caspase-9 and increasing the expression of Bcl-2.


Assuntos
Apoptose , Fadiga/fisiopatologia , Glucosídeos/farmacologia , Coração/efeitos dos fármacos , Isquemia Miocárdica/tratamento farmacológico , Fenóis/farmacologia , Animais , Biomarcadores/sangue , Feminino , Masculino , Miocárdio/citologia , Condicionamento Físico Animal , Ratos , Ratos Sprague-Dawley
2.
Arq Gastroenterol ; 56(3): 252-255, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31633720

RESUMO

BACKGROUND: Fatigue is highly prevalent in end stage liver disease, the studies about its association with exercise capacity in cirrhotic patients before liver are scarse. OBJECTIVE: In this study, we evaluated fatigue in 95 in end stage liver disease patients awaiting transplantation, compared to healthy volunteers, and tested the association between exercise capacity and fatigue. METHODS: Cross-sectional study of patients with chronic liver disease treated at a referral center in Fortaleza, Brazil. Fatigue was quantified with the Fatigue Severity Scale. The patients were submitted to the 6-min walk test, the 6-min step test, the Hospital Anxiety and Depression Scale, C-reative protein measurement and hematocrit count, measurement of dyspnea among other tests. Fatigue data were obtained from healthy individuals for comparison with patients. RESULTS: The mean age of patients was 45.9±12.3 years, and 53.7% were male. Fatigue, anxiety and depression levels were higher among end stage liver disease patients than among controls. A negative correlation was observed between 6 min step test and Fatigue Severity Scale score (r= -0.2; P=0.02) and between hematocrit count and Fatigue Severity Scale score (r= -0.24; P=0.002). Dyspnea on the Borg scale and fatigue were positively correlated (r=31; P=0.002). In the multivariate analysis, low 6-min step test values and high levels of dyspnea were associated with fatigue. CONCLUSION: Fatigue was more prevalent and severe in end stage liver disease patients than in healthy controls. Low 6MST values and high levels of dyspnea were associated with fatigue in this scenario.


Assuntos
Doença Hepática Terminal/psicologia , Tolerância ao Exercício/fisiologia , Fadiga/psicologia , Transplante de Fígado/psicologia , Adulto , Transtornos de Ansiedade/psicologia , Estudos Transversais , Transtorno Depressivo/psicologia , Doença Hepática Terminal/fisiopatologia , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Listas de Espera
3.
Postgrad Med ; 131(7): 453-460, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31469966

RESUMO

Objectives: Recent evidence suggests an association between functional capacity and cognitive function, at least in older adults. The aim of this cross-sectional study was to examine the association between cognitive function, functional capacity, isokinetic leg strength, health-related quality of life (HRQOL), sleep quality, body fat, handgrip strength, and fatigue among a sample of MS patients. Methods: Fifty-one relapsing-remitting MS patients (age: 38.4 ± 7.1 yrs; 30 females) were recruited and agreed to participate in this study. Cognitive function was assessed by the Paced Auditory Serial Addition Test (PASAT). Functional capacity was examined using various functional tests commonly used in MS patients. Maximal voluntary unilateral leg strength was assessed using isokinetic dynamometer. Isometric handgrip strength was assessed by a dynamometer. Total body and visceral fat levels were assessed via bioelectrical impedance analyzers. Finally, the patients' HRQOL, sleep quality, and fatigue levels were evaluated using specific questionnaires. Results: A significant association was found between the PASAT score and the performance score in various functional capacity tests (p < 0.050). On the other hand, a weak but statistically significant association was found between the PASAT score and isokinetic strength of knee extensors (r = 0.319, p = 0.022) and knee flexors (r = 0.354 p = 0.011). Poor sleep quality was associated with lower performance in all the functional capacity tests examined (p < 0.05) whilst was negatively associated with the PASAT score (r = -0.334, p = 0.017). The multivariate regression analysis revealed that the performance on the TUG test was a significant predictor of cognitive function. Conclusion: Based on the results of this study, functional capacity was found to be associated with both impaired cognitive performance and low HRQOL in MS patients. In addition, an association between sleep quality and cognitive performance was revealed, confirming existing literature. Functional capacity as assessed by the TUG test emerged as the best predictor of cognitive function.


Assuntos
Cognição , Fadiga/fisiopatologia , Força da Mão/fisiologia , Esclerose Múltipla Recidivante-Remitente/fisiopatologia , Qualidade de Vida , Tecido Adiposo , Adulto , Composição Corporal , Estudos Transversais , Impedância Elétrica , Fadiga/psicologia , Feminino , Músculos Isquiotibiais , Humanos , Gordura Intra-Abdominal , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/psicologia , Força Muscular/fisiologia , Testes Neuropsicológicos , Músculo Quadríceps , Sono , Inquéritos e Questionários , Teste de Caminhada
4.
J Electromyogr Kinesiol ; 48: 197-204, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31442925

RESUMO

PURPOSE: People with Joint Hypermobility Syndrome (JHS) suffer with fatigue. The purpose of this project was to investigate the contribution of central and peripheral fatigue. METHODS: Electrical stimulation of the musculocutaneous nerve to biceps brachii, and transcranial magnetic stimulation over the motor cortex supplying biceps brachii were used. Peripheral and central fatigue were assessed during a control, fatiguing and recovery phase protocol. RESULTS: JHS participants perceived greater fatigue during the protocol compared to a control group and did not recover. Central and peripheral fatigue did not occur in the control group. However, the JHS group showed central fatigue. MEP amplitude increased in the JHS group during the fatiguing protocol (p < 0.01) before recovering. Superimposed twitch amplitude increased in the JHS group during the fatiguing protocol and stayed elevated during the recovery phase (p < 0.04). Time to peak (TTP) amplitude of the torque generated by the TMS was longer in the JHS group (p < 0.05). RMS during MVCs decreased during the fatiguing protocol reaching significance during the recovery phase (p < 0.01). CONCLUSION: JHS participants suffered central but not peripheral fatigue. A modified strength programme to target this is discussed.


Assuntos
Fadiga/etiologia , Instabilidade Articular/fisiopatologia , Córtex Motor/fisiopatologia , Fadiga Muscular , Nervos Periféricos/fisiopatologia , Adulto , Fadiga/fisiopatologia , Feminino , Humanos , Instabilidade Articular/complicações , Masculino , Músculo Esquelético/inervação , Músculo Esquelético/fisiopatologia , Torque
5.
J Acupunct Meridian Stud ; 12(4): 111-121, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31351997

RESUMO

Many functional diseases are related to dysautonomia, and heart rate variability has been used to assess dysautonomia. However, heart rate variability has not been studied in Spleen-Qi deficiency syndrome (SQDS). Healthy volunteers (n = 37) and patients with SQDS (n = 67), recruited from the Clinic of the State University of Ecatepec Valley were included in the study. Outcome measures were average heart rate, standard deviation of the normal-to-normal heartbeat intervals, low frequency (LF), high frequency (HF) power, and the LF/HF ratio. Also, intestinal peristalsis, gastrointestinal symptoms (GSs), fatigue, and level of attention were measured. Standard deviation of the normal-to-normal heartbeat intervals (17 ± 2.3%) and HF (14 ± 3.1%) were lower in SQDS patients (17 ± 1.3%) than in healthy volunteers. SQDS patients had higher heart rate, LF power, LF/HF ratio, and fatigue scores (9.6 ± 1.12%, 16 ± 2.1%, 22 ± 3.8%, and 21 ± 4.1%). The fatigue correlated positively with the LF/HF ratio and negatively with HF power. The SQDS group had lower concentration performance (16.2 ± 1.9%) in the d2 test. The intestinal peristalsis showed a reduction (15 ± 1.3%) as compared with control. GS score and peristalsis correlated negatively with HF. Our results suggest that the pathology of SDQS could be associated with a low vagal tone which causes a decrease in peristalsis, increased fatigue, reduced attention, and appearance of GSs.


Assuntos
Frequência Cardíaca , Qi , Baço/fisiopatologia , Deficiência da Energia Yin/fisiopatologia , Adulto , Estudos Transversais , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Deficiência da Energia Yin/diagnóstico
6.
Am J Occup Ther ; 73(4): 7304205040p1-7304205040p9, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31318668

RESUMO

OBJECTIVE: We investigated whether demographic, disease-related, or personal baseline determinants can predict a positive response to energy conservation management (ECM). METHOD: We conducted a secondary analysis of a single-blind, two-parallel-arms randomized controlled trial that included ambulatory adults with severe MS-related fatigue. Therapy responders and nonresponders were categorized by Checklist Individual Strength fatigue change scores between baseline and end of treatment. Logistic regression analyses were used to assess the determinants of response. RESULTS: Sixty-nine participants were included (ECM group, n = 34; control group, n = 35). In the ECM group, fatigue severity, perception of fatigue, illness cognitions about MS, and social support discrepancies were related to the probability of being a responder. CONCLUSION: The results suggest that people with MS-related fatigue who had a less negative perception of fatigue and who perceived fewer disease benefits and a higher discrepancy in social support had the best response to ECM treatment.


Assuntos
Fadiga/fisiopatologia , Esclerose Múltipla , Humanos , Método Simples-Cego
7.
Medicine (Baltimore) ; 98(26): e15947, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31261500

RESUMO

To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted.Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ±â€Š12.5 years, disease duration 8.7 ±â€Š7.4 years). Mean change in C-reactive protein level from baseline to week 12 was -11.2 ±â€Š4.0 (P < .001). Mean Disease Activity Index score (DAS28) decreased from 5.5 ±â€Š1.0 at baseline to 2.7 ±â€Š1.3 (P < .001) at week 24. Mean change in Functional Assessment of Chronic Illness Therapy score was -5.4 ±â€Š11.2 points at week 24. Multiple regression analysis showed that the improvement in DAS28, sleep, and depression explained 56% and 47% of fatigue variance at week 12 and 24, respectively.Tocilizumab is effective in reducing disease activity and results in a clinically significant improvement in fatigue, pain, swollen joint count, morning stiffness, sleepiness, depression, and DAS28; the last 3 were specifically identified as factors explaining fatigue variance with the use of TCZ in RA patients.


Assuntos
Anticorpos Monoclonais Humanizados/uso terapêutico , Artrite Reumatoide/psicologia , Artrite Reumatoide/terapia , Fadiga/psicologia , Fadiga/terapia , Antirreumáticos/uso terapêutico , Artrite Reumatoide/fisiopatologia , Biomarcadores/metabolismo , Proteína C-Reativa/metabolismo , Depressão/fisiopatologia , Depressão/terapia , Fadiga/etiologia , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Retratamento , Sono , Resultado do Tratamento , Fator de Necrose Tumoral alfa/uso terapêutico
8.
BMC Public Health ; 19(1): 709, 2019 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-31174515

RESUMO

BACKGROUND: The combined association of physical activity and sedentary behavior with adverse health factors is not yet clear in the literature. A combined analysis of physical activity level and sedentary behavior may provide evidence of the interrelation between these behavioral variables and the frailty syndrome. Thus, the aim of this study was to examine the relationship between physical activity level, sedentary behavior and frailty in older adults. METHODS: In this study, we evaluated 457 older adults (age range = 60 to 96 years old) from the Longitudinal Study of the Elderly Health of Alcobaça, Bahia. The frailty condition was defined by the presence of three or more of the following criteria: unintentional weight loss, slow walking speed measured over a 4.57 m test, a reduction of manual grip strength and exhaustion. Based upon these criteria, participants were classified as non-frail or frail. Physical activity level and time spent in sedentary behavior were assessed with the International Questionnaire of Physical Activity. Descriptive statistics were used to characterize the sample. To examine the combined association of physical activity and sedentary behavior with frailty, chi-square and Poisson regression tests were used. Statistical significance was defined as p ≤ 0.05. RESULTS: The prevalence of frailty was 8.8% (n = 40), with higher prevalence observed with increasing age. Low physical activity level combined with excessive time spent in sedentary behavior (physical activity level < 150 min/wk. and sedentary behavior ≥540 min/day) was associated with frailty, resulting in a prevalence ratio of 2.83 (95% CI, 1.23 to 6.52). CONCLUSION: Frailty is more prevalent among older adults who exhibit insufficient levels of physical activity combined with a great amount of time spent in sedentary behavior, even when adjusted for sociodemographic factors.


Assuntos
Exercício , Idoso Fragilizado/estatística & dados numéricos , Fragilidade/epidemiologia , Comportamento Sedentário , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Fadiga/fisiopatologia , Feminino , Fragilidade/fisiopatologia , Fragilidade/psicologia , Força da Mão , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Prevalência , Perda de Peso
9.
Nat Commun ; 10(1): 2767, 2019 06 24.
Artigo em Inglês | MEDLINE | ID: mdl-31235694

RESUMO

The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid. This reduces kynurenine-associated neurotoxicity and generates glutamate as a byproduct. Here, we show that PGC-1α1 elevates aspartate and glutamate levels and increases the expression of glycolysis and malate-aspartate shuttle (MAS) genes. These interconnected processes improve energy utilization and transfer fuel-derived electrons to mitochondrial respiration. This PGC-1α1-dependent mechanism allows trained muscle to use kynurenine metabolism to increase the bioenergetic efficiency of glucose oxidation. Kat inhibition with carbidopa impairs aspartate biosynthesis, mitochondrial respiration, and reduces exercise performance and muscle force in mice. Our findings show that PGC-1α1 activates the MAS in skeletal muscle, supported by kynurenine catabolism, as part of the adaptations to endurance exercise. This crosstalk between kynurenine metabolism and the MAS may have important physiological and clinical implications.


Assuntos
Metabolismo Energético/fisiologia , Fadiga/fisiopatologia , Cinurenina/metabolismo , Músculo Esquelético/metabolismo , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo , Adaptação Fisiológica , Animais , Aspartato Aminotransferases/metabolismo , Ácido Aspártico/metabolismo , Carbidopa/farmacologia , Respiração Celular/efeitos dos fármacos , Respiração Celular/fisiologia , Metabolismo Energético/efeitos dos fármacos , Glicólise/fisiologia , Malatos/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Modelos Animais , Músculo Esquelético/fisiopatologia , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética , Condicionamento Físico Animal/fisiologia , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Transaminases/antagonistas & inibidores , Transaminases/metabolismo
10.
Sensors (Basel) ; 19(12)2019 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-31212742

RESUMO

With the development of the Internet of Battlefield Things (IoBT), soldiers have become key nodes of information collection and resource control on the battlefield. It has become a trend to develop wearable devices with diverse functions for the military. However, although densely deployed wearable sensors provide a platform for comprehensively monitoring the status of soldiers, wearable technology based on multi-source fusion lacks a generalized research system to highlight the advantages of heterogeneous sensor networks and information fusion. Therefore, this paper proposes a multi-level fusion framework (MLFF) based on Body Sensor Networks (BSNs) of soldiers, and describes a model of the deployment of heterogeneous sensor networks. The proposed framework covers multiple types of information at a single node, including behaviors, physiology, emotions, fatigue, environments, and locations, so as to enable Soldier-BSNs to obtain sufficient evidence, decision-making ability, and information resilience under resource constraints. In addition, we systematically discuss the problems and solutions of each unit according to the frame structure to identify research directions for the development of wearable devices for the military.


Assuntos
Técnicas Biossensoriais , Monitorização Fisiológica/métodos , Dispositivos Eletrônicos Vestíveis , Tecnologia sem Fio , Fadiga/diagnóstico , Fadiga/fisiopatologia , Humanos , Militares , Análise de Sistemas
11.
BMC Musculoskelet Disord ; 20(1): 194, 2019 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-31054567

RESUMO

BACKGROUND: Fatigue is a major symptom of rheumatoid arthritis (RA). There is some evidence that physical activity (PA) may be effective in reducing RA fatigue. However, few PA interventions have been designed to manage fatigue and there is limited evidence of end-user input into intervention development. The aim of this research was to co-design an intervention to support self-management of RA fatigue through modifying PA. METHODS: A series of studies used mixed methodological approaches to co-design a fatigue management intervention focused on modifying PA based on UK Medical Research Council guidance, and informed by the Behaviour Change Wheel theoretical framework. Development was based on existing evidence, preferences of RA patients and rheumatology healthcare professionals, and practical issues regarding intervention format, content and implementation. RESULTS: The resulting group-based intervention consists of seven sessions delivered by a physiotherapist over 12 weeks. Each session includes an education and discussion session followed by supervised PA chosen by the participant. The intervention is designed to support modification and maintenance of PA as a means of managing fatigue. This is underpinned by evidence-based behaviour change techniques that might support changes in PA behaviour. Intervention delivery is interactive and aims to enhance capability, opportunity and motivation for PA. CONCLUSION: This study outlines stages in the systematic development of a theory-based intervention designed through consultation with RA patients and healthcare professionals to reduce the impact of RA fatigue. The feasibility of future evaluation of the intervention should now be determined.


Assuntos
Artrite Reumatoide/complicações , Terapia Cognitivo-Comportamental/métodos , Exercício/psicologia , Fadiga/reabilitação , Motivação , Adulto , Idoso , Artrite Reumatoide/fisiopatologia , Artrite Reumatoide/psicologia , Exercício/fisiologia , Fadiga/etiologia , Fadiga/fisiopatologia , Fadiga/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Encaminhamento e Consulta , Projetos de Pesquisa , Reumatologistas , Resultado do Tratamento
12.
J Med Food ; 22(4): 355-364, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30990752

RESUMO

Our study aimed to investigate the effects of the polysaccharide-rich extract of Phragmites rhizoma (PEP) against water immersion restraint (WIR) stress and forced swimming-induced fatigue. Exposure to WIR stress significantly increased the ulcer index, bleeding score, the weight of the adrenal gland, blood glucose concentrations, total cholesterol, cortisol, and creatine kinase (CK). The weight of the spleen decreased significantly. In addition, myeloperoxidase (MPO) and thiobarbituric acid-reactive substance (TBARS) were significantly upregulated by WIR stress. The antioxidative factors such as glutathione (GSH) and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the stomach were decreased by WIR stress. Alterations induced by WIR stress were effectively reversed by pretreatment with PEP. The swimming endurance capacity of mice was significantly prolonged by the oral administration of PEP. Swimming-induced fatigue significantly reduced the body weight; however, the injection of PEP inhibited the decrease of body weight. The PEP-treated group had significantly lower CK levels in plasma, an indicator of muscle damage. These results indicated that PEP has anti-stress and anti-fatigue effects, which are mediated by suppressing the hyperactivation of the hypothalamus-pituitary-adrenal axis, and antagonism of the oxidative damages induced by WIR stress and prolonged swimming times.


Assuntos
Fadiga/tratamento farmacológico , Extratos Vegetais/administração & dosagem , Poaceae/química , Polissacarídeos/administração & dosagem , Animais , Catalase/metabolismo , Modelos Animais de Doenças , Fadiga/metabolismo , Fadiga/fisiopatologia , Glutationa/metabolismo , Glutationa Peroxidase/metabolismo , Humanos , Masculino , Camundongos , Camundongos Endogâmicos ICR , Peroxidase/metabolismo , Extratos Vegetais/química , Polissacarídeos/química , Rizoma/química , Estresse Fisiológico/efeitos dos fármacos , Superóxido Dismutase/metabolismo , Natação
13.
Biol Psychol ; 144: 115-124, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30930071

RESUMO

Fatigue induced by sustained cognitive demands often entails decreased behavioural performance and the unavailability of brain resources, either due to reduced levels or impaired access. In the present study, we investigated the neural dynamics underlying preserved behavioural performance after inducing cognitive fatigue (CF) in a sleep deprivation (SD) condition in which resources are naturally compromised. Using functional near infrared spectroscopy (fNIRS), we recorded cortical brain activity during task-related CF induction in the evening, in the middle of the night and early in the morning. Although cortical oxygenation similarly increased over the 3 sessions, decreased intra-hemispheric connectivity between left anterior frontal and frontal areas paralleled a sudden drop in task performance in the early morning. Our data indicate that decreased sustained attention after the induction of cognitive fatigue in a situation of high sleep pressure results from impaired connectivity between left prefrontal cortical areas rather than from a mere modulation in brain resources.


Assuntos
Disfunção Cognitiva/psicologia , Fadiga/psicologia , Córtex Pré-Frontal/diagnóstico por imagem , Privação do Sono/psicologia , Análise e Desempenho de Tarefas , Adulto , Atenção , Encéfalo/diagnóstico por imagem , Encéfalo/fisiopatologia , Cognição , Disfunção Cognitiva/diagnóstico por imagem , Disfunção Cognitiva/fisiopatologia , Fadiga/diagnóstico por imagem , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Imagem Óptica/métodos , Córtex Pré-Frontal/fisiopatologia , Sono , Privação do Sono/diagnóstico por imagem , Privação do Sono/fisiopatologia , Espectroscopia de Luz Próxima ao Infravermelho , Fatores de Tempo , Adulto Jovem
14.
Aerosp Med Hum Perform ; 90(5): 466-474, 2019 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-31023407

RESUMO

BACKGROUND: Airline crew are being exposed to extended workdays and compressed work periods, with quick returns between duties, implying a heightened physiological and psychological strain that may lead to sleep deprivation and fatigue. The aim of the study was assessment of the effect of an extended day of flight duty and a compressed work week with regard to recovery, cumulative fatigue, and neurobehavioral performance.METHODS: We followed 18 pilots and 41 cabin crewmembers during four consecutive days of flight duty, comprising a total of ≥ 39 h, where the first day was ≥ 10 h. Information on demographics, work characteristics, health status, and physical activity was collected at baseline. Subjects completed logs for the first and fourth workday, including the Samn-Perelli Fatigue Checklist at three time points during these workdays. Two computer-based neurobehavioral tests were completed the evening prior to the first shift, and after the first and the fourth day of the work period.RESULTS: Number of flight sectors during the work period was 10-20. Self-reported fatigue levels increased during the workdays. Neurobehavioral test-scores did not deteriorate. The effects of each additional flight sector during the work period was elevated reaction times (RT) both among cabin crewmembers (B = 5.05 ms, 95% CI 0.6, 9.5) and pilots (B = 4.95 ms, 95% CI 0.4, 9.5). Precision was unaffected.DISCUSSION: Airline pilots and cabin crewmembers seem to obtain satisfactory sleep before and during the period of 4 consecutive days. The association between multiple flight sectors and increased fatigue supports previous findings.Goffeng EM, Wagstaff A, Nordby K-C, Meland A, Goffeng LO, Skare Ø, Lilja D, Lie J-AS. Risk of fatigue among airline crew during 4 consecutive days of flight duty. Aerosp Med Hum Perform. 2019; 90(5):466-474.


Assuntos
Medicina Aeroespacial/estatística & dados numéricos , Fadiga/epidemiologia , Doenças Profissionais/epidemiologia , Privação do Sono/complicações , Tolerância ao Trabalho Programado/fisiologia , Actigrafia , Adulto , Aviação/estatística & dados numéricos , Comércio/estatística & dados numéricos , Fadiga/diagnóstico , Fadiga/etiologia , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Noruega/epidemiologia , Doenças Profissionais/diagnóstico , Doenças Profissionais/etiologia , Doenças Profissionais/fisiopatologia , Pilotos/estatística & dados numéricos , Fatores de Tempo
15.
Int J Rehabil Res ; 42(2): 180-186, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31034453

RESUMO

The aim of this study was to investigate the physical activity (PA) level of adults with muscle diseases and the association of factors affecting PA behaviour. Forty-five adults with muscle diseases and 44 healthy participants were included. The PA was assessed by a SenseWear Armband and the International Physical Activity Questionnaire. The muscle strength, pain, fatigue severity, activity limitations, functional mobility level and quality of life were also assessed. Compared with the healthy group, adults with muscle diseases had significantly lower step counts and duration of moderate and vigorous PA (P < 0.05). The BMI of the patients was related to total energy expenditure (P < 0.05). The total number of steps, energy expenditure and duration of moderate PA of the patients were related to the 6-min walk test (P < 0.05). There was a correlation between total, moderate and vigorous PA and mental health in adults with muscle diseases (P < 0.05). The most important factors in reflecting PA in adults with muscle diseases are considered as BMI from personal factors, functional mobility from activity limitations and quality of life in the dimension of participation.


Assuntos
Exercício/fisiologia , Classificação Internacional de Funcionalidade, Incapacidade e Saúde , Doenças Musculares/fisiopatologia , Adulto , Estudos de Casos e Controles , Estudos Transversais , Metabolismo Energético/fisiologia , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Força Muscular/fisiologia , Dor/fisiopatologia , Qualidade de Vida , Escala Visual Analógica , Teste de Caminhada , Dispositivos Eletrônicos Vestíveis
16.
Eur J Appl Physiol ; 119(7): 1479-1489, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30953177

RESUMO

OBJECTIVE: This study aimed to verify the acute and prolonged effects of stretch-shortening cycle exercise (SSC) on performance and neuromuscular function following a 4-km cycling time trial (4-km TT). METHODS: On separate days, individuals performed a 4-km TT without any previous exercise (CON), immediately (ACUTE) and 48 h after (PROL) SSC protocol (i.e., 100-drop jumps). Neuromuscular function was measured at baseline SSC (baseline), before (pre-TT) and after (post-TT) 4-km TT. Muscle soreness and inflammatory responses also were assessed. RESULTS: The endurance performance was impaired in both ACUTE (- 2.3 ± 1.8%) and PROL (- 1.8 ± 2.4%) compared with CON. The SSC protocol caused also an acute reduction in neuromuscular function, with a greater decrease in potentiated quadriceps twitch-force (Qtw.pot - 49 ± 16%) and voluntary activation (VA - 6.5 ± 7%) compared for CON and PROL at pre-TT. The neuromuscular function was fully recovered 48 h after SSC protocol. Muscle soreness and IL-10 were elevated only 48 h after SSC protocol. At post-TT, Qtw.pot remained lower in ACUTE (- 52 ± 14%) compared to CON (- 29 ± 7%) and PROL (- 31 ± 16%). CONCLUSION: These findings demonstrate that impairment in endurance performance induced by prior SSC protocol was mediated by two distinct mechanisms, where the acute impairment was related to an exacerbated degree of peripheral and central fatigue, and the prolonged impairment was due to elevated perceived muscle soreness.


Assuntos
Fadiga/etiologia , Contração Isométrica , Fadiga Muscular , Resistência Física , Exercício Pliométrico/métodos , Adulto , Fadiga/fisiopatologia , Humanos , Interleucinas/sangue , Ácido Láctico/sangue , Masculino , Exercício Pliométrico/efeitos adversos
17.
Clin J Sport Med ; 29(3): 193-202, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-31033612

RESUMO

OBJECTIVE: To investigate the effect of corrective exercises on functional movement patterns, sensorimotor function, self-reported function, and fatigue sensitivity in collegiate athletes with chronic ankle instability (CAI). DESIGN: A randomized controlled trial. SETTING: Laboratory of sports sciences. PARTICIPANTS: Forty male volunteers were randomly assigned to the experimental group (age 21.2 ± 1.7 years, height 174.5 ± 6.1 cm, and weight 69.6 ± 6.9 kg) or the control group (age 20.9 ± 1.8 years, height 178.2 ± 6.6 cm, and weight 68.8 ± 8.1 kg). INTERVENTION: Participants in the experimental group performed supervised corrective exercises 3 times per week for 8 weeks. Fatigue was induced with a progressive treadmill protocol before and after the 8-week intervention. MAIN OUTCOME MEASURES: Outcomes included movement efficiency during 3 squat tasks, static and dynamic postural control, strength of the ankle musculature, joint position sense, and self-reported function with the Foot and Ankle Ability Measure subscales. These outcomes were assessed before and immediately after fatiguing treadmill running both before and after 8-weeks of corrective exercises. RESULTS: Significant improvements in movement efficiency, sensorimotor function, and self-reported function were noted in the experimental group relative to the control group (P < 0.001), in a nonfatigued state. However, in a fatigued stated, the experimental intervention only improved static postural control (P = 0.016) relative to the control group. CONCLUSIONS: These findings demonstrate that 8-weeks of corrective exercises were effective at enhancing movement efficiency, sensorimotor function, and self-reported function in collegiate athletes with CAI. However, this intervention program has limited abilities at reducing the effects of fatigue.


Assuntos
Articulação do Tornozelo/fisiopatologia , Terapia por Exercício , Fadiga/fisiopatologia , Instabilidade Articular/terapia , Atletas , Humanos , Masculino , Movimento , Autorrelato , Adulto Jovem
18.
J Strength Cond Res ; 33(5): 1311-1319, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31033774

RESUMO

Noble, EB, Pilarski, JM, Vora, HK, Zuniga, JM, and Malek, MH. Log-transformed electromyography amplitude-power output relationship: single-leg knee-extensor versus single-leg cycle ergometry. J Strength Cond Res 33(5): 1311-1319, 2019-Comparing and contrasting motor unit recruitment and activation for the same muscles for multiple versus single-joint exercise may provide a better understanding of neuromuscular fatigue. The purpose of this study, therefore, is to compare the slope and y-intercept terms for the 3 superficial quadriceps femoris (QF) (vastus lateralis, rectus femoris, and vastus medialis) muscles derived from the log-transformed electromyography (EMG) amplitude-power output relationship between the single-leg knee-extensor ergometry (KE) and the single-leg cycle ergometry (CE). Ten healthy college-aged men who engaged in regular physical activity visited the laboratory on 2 occasions separated by 7 days to perform either single-leg CE or single-leg KE in a randomized order. For each visit, subjects performed incremental exercise until voluntary fatigue. Electromyography electrodes were placed on the superficial QF muscles. The slope and y-intercept terms, for each muscle, for the EMG amplitude versus power output relationship was examined using the log-transformed model for each subject's data. The results indicated no significant (p > 0.05) mean differences for either slope or y-intercept terms between exercise modes and across muscles. In addition, separate repeated-measures analyses of variance (ANOVAs) were used to determine mean differences for the slope and y-intercept values between the 3 muscles. In addition, separate 2 (mode: CE or KE) × intensity (intensity: 30, 60, and 90% of maximal workload) repeated-measures ANOVAs were conducted for each muscle. There was a significant (p < 0.05) mode × exercise intensity interaction for each muscle. Follow-up testing indicated that in most cases, the normalized EMG amplitude was significantly higher for single-leg KE than single-leg CE. These results indicated that incremental single-leg KE activates the superficial QF muscles significantly greater than single-leg CE.


Assuntos
Exercício/fisiologia , Fadiga/fisiopatologia , Articulação do Joelho/fisiologia , Músculo Quadríceps/fisiologia , Adulto , Fenômenos Biomecânicos , Eletromiografia/métodos , Ergometria/métodos , Teste de Esforço/métodos , Humanos , Masculino , Músculo Esquelético/fisiologia , Adulto Jovem
19.
Value Health ; 22(4): 453-466, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30975397

RESUMO

OBJECTIVES: A new patient-reported outcome (PRO) instrument to measure fatigue symptoms and impacts in relapsing multiple sclerosis (RMS) was developed in a qualitative stage, followed by psychometric validation and migration from paper to an electronic format. METHODS: Adult patients with relapsing-remitting multiple sclerosis (RRMS) were interviewed to elicit fatigue-related symptoms and impacts. A draft questionnaire was debriefed in cognitive interviews with further RRMS patients, and revised. Content confirmation interviews were conducted with patients with progressive-relapsing multiple sclerosis (PRMS) and relapsing secondary-progressive multiple sclerosis (RSPMS). Psychometric analyses used data from adult patients with different RMS subtypes and matched non-RMS controls in a multicenter, observational study. After item reduction, the final instrument was migrated to a smartphone (eDiary) and usability was confirmed in interviews with additional adult RMS patients. RESULTS: The qualitative stage included 37 RRMS, 5 PRMS, and 5 RSPMS patients. Saturation of concepts was reached during concept elicitation. Cognitive interviews confirmed that participants understood the instructions, items, and response options of the instrument-named FSIQ-RMS-as intended. Psychometric validation included 164 RMS and 74 control patients. Internal consistency and test-retest reliability were demonstrated. The symptoms domain discriminated along the RMS symptom-severity continuum and between patients and controls. Patients were able to attribute fatigue-related symptoms to RMS. Usability and conceptual equivalence of the eDiary were confirmed (n = 10 participants). CONCLUSIONS: With 7 symptom items and 13 impact items (in 3 impacts subdomains: physical, cognitive and emotional, and coping) after item reduction, the FSIQ-RMS is a comprehensive, valid, and reliable measure of fatigue-related symptoms and impacts in RMS patients.


Assuntos
Fadiga/diagnóstico , Indicadores Básicos de Saúde , Esclerose Múltipla Recidivante-Remitente/diagnóstico , Medidas de Resultados Relatados pelo Paciente , Atividades Cotidianas , Adolescente , Adulto , Idoso , Cognição , Compreensão , Efeitos Psicossociais da Doença , Estudos Transversais , Fadiga/epidemiologia , Fadiga/fisiopatologia , Fadiga/psicologia , Feminino , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla Recidivante-Remitente/epidemiologia , Esclerose Múltipla Recidivante-Remitente/fisiopatologia , Esclerose Múltipla Recidivante-Remitente/psicologia , Valor Preditivo dos Testes , Psicometria , Pesquisa Qualitativa , Reprodutibilidade dos Testes , Adulto Jovem
20.
Aerosp Med Hum Perform ; 90(4): 415-418, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30922431

RESUMO

BACKGROUND: Mental fatigue and sleepiness are well recognized determinants of human-error related accidents and incidents in aviation. In Brazil, according to the Center for Investigation and Prevention of Aeronautical Accidents (CENIPA), the rate of accidents in the aerial modal is 1 per 2 d. Human factors are present in 90% of these accidents.CASE REPORT: This paper describes a retrospective study of the communication between a pilot and an air traffic control tower just before a fatal accident. The objective was the detection of fatigue and sleepiness of a pilot, who complained of these signs and symptoms before the flight, by means of voice and speech analysis. The in-depth accident analysis performed by CENIPA indicated that sleepiness and fatigue most likely contributed to the accident. Speech samples were analyzed for two conditions: 1) nonsleepy data recorded 35 h before the air crash (control condition), which were compared with 2) data from samples collected about 1 h before the accident and also during the disaster (sleepy condition). Audio recording analyses provided objective measures of the temporal organization of speech, such as hesitations, silent pauses, prolongation of final syllables, and syllable articulation rate.DISCUSSION: The results showed that speech during the day of the accident had significantly low elocution and articulation rates compared to the preceding day, also indicating that the methodology adopted in this study is feasible for detection of fatigue and sleepiness through speech analysis.de Vasconcelos CA, Vieira MN, Kecklund G, Yehia HC. Speech analysis for fatigue and sleepiness detection of a pilot. Aerosp Med Hum Perform. 2019; 90(4):415-418.


Assuntos
Prevenção de Acidentes/métodos , Acidentes Aeronáuticos/prevenção & controle , Fadiga/diagnóstico , Sonolência , Acústica da Fala , Prevenção de Acidentes/instrumentação , Acidentes Aeronáuticos/estatística & dados numéricos , Brasil , Fadiga/fisiopatologia , Estudos de Viabilidade , Humanos , Masculino , Pessoa de Meia-Idade , Fonética , Estudos Retrospectivos , Software , Vigília/fisiologia
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