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1.
BMC Infect Dis ; 20(1): 280, 2020 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-32295546

RESUMO

BACKGROUND: Fatigue is one of the most common and devastating Human Immuno-deficiency Virus (HIV) - related symptoms, with a varying prevalence in different study areas. In Ethiopia, there is a paucity of information on the magnitude and factors associated with fatigue among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients. This may lead to under-diagnosis and eventually under-management of the symptom. METHODS: Institution based cross-sectional study design was conducted among 609 HIV/AIDS patients who were selected by using a systematic random sampling method. Data were collected by using interviewer administered structured questionnaire. Level of fatigue was measured by Fatigue Severity Scale. RESULTS: The prevalence of fatigue was found to be 51.7%. The factors associated with fatigue were: Parity [AOR = 2.01; 95% CI: 1.09-3.71], CD4 count 200-499 cells/mm3 [AOR = 2.81; 95% CI: 1.58-4.99], anemia [AOR = 4.90 95% CI: 2.40-9.97], co-morbidities [AOR = 3.65; 95% CI: 1.71-7.78], depression [AOR = 3.68 95% CI: 1.99-6.79], not being physically active [AOR = 3.20 95% CI: 1.50-6.81], clinical stage II or IV HIV [AOR = 3.11; 95% CI: 1.51-6.40] and [AOR = 4.08; 95% CI: 1.37-12.14], respectively. CONCLUSION: The finding of this study revealed that fatigue is a common health problem among adult People Living with HIV (PLHIV). Factors associated with fatigue included: Parity, CD4 count 200-499 cells/mm3, Clinical Stage II or IV HIV, anemia, co-morbidities, depression, and not being physically active. The health care service needs to address the predisposing factors by provision integrated care including timely detection and treatment of comorbidities, mental health problems, and promote physical activity to slow down disease progression and then reduce exposure to fatigue.


Assuntos
Síndrome de Imunodeficiência Adquirida/tratamento farmacológico , Síndrome de Imunodeficiência Adquirida/epidemiologia , Antirretrovirais/uso terapêutico , Fadiga/epidemiologia , Síndrome de Imunodeficiência Adquirida/patologia , Adulto , Anemia/complicações , Contagem de Linfócito CD4 , Comorbidade , Estudos Transversais , Depressão/complicações , Etiópia/epidemiologia , Fadiga/etiologia , Fadiga/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paridade , Gravidez , Prevalência , Comportamento Sedentário , Índice de Gravidade de Doença , Inquéritos e Questionários
2.
BMJ ; 368: m512, 2020 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-32144210

RESUMO

The studyHewlett S, Almeida C, Ambler N, et al. Reducing arthritis fatigue impact: two-year randomised controlled trial of cognitive behavioural approaches by rheumatology teams (RAFT). Ann Rheum Dis 2019;78:465-72.Hewlett S, Almeida C, Ambler N, et al. Group cognitive behavioural programme to reduce the impact of rheumatoid arthritis fatigue: the RAFT RCT with economic and qualitative evaluations. Health Technol Assess 2019;23:57.This project was funded by the NIHR Health Technology Assessment Programme (project number 11/112/01).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000860/group-cognitive-behavioural-courses-may-reduce-fatigue-from-rheumatoid-arthritis.


Assuntos
Artrite Reumatoide/complicações , Terapia Cognitivo-Comportamental/métodos , Fadiga/prevenção & controle , Fadiga/terapia , Psicoterapia de Grupo/métodos , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
3.
J Sports Sci ; 38(9): 961-969, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32138596

RESUMO

This study examined the effects of lower-body compression garments on perceived recovery and subsequent performance in basketball athletes. In a parallel-group design, 30 recreational, male basketball athletes were randomly allocated to either a control (CON, n = 15, loose-fitting clothing) or experimental group (COMP, n = 15, compression garments) for 15 h following fatigue-inducing, basketball-specific exercise in the evening (1600-1800 h). Perceptual measures of fatigue and muscle soreness, as well as physical performance tests (sprints, jumps and agility), were performed pre-exercise, post-exercise, and post-recovery (15 h following exercise). Subjective and objective measures of sleep were recorded following the exercise trial. There were non-significant (p > 0.05), unclear-trivial differences between groups for all performance measures. Perceived post-recovery fatigue (d = -1.27, large) and muscle soreness (d = -1.61, large) were significantly lower in COMP compared to CON (p < 0.05). COMP exhibited better perceived sleep quality (d = 0.42, small, p = 0.18) than CON, with an unclear difference in sleep duration between groups (p > 0.05). Wearing lower-body compression garments overnight improved perceived fatigue and muscle soreness, but had negligible effects on subsequent physical performance in basketball athletes. Future research should focus on longer periods of compression wear following fatiguing exercise.


Assuntos
Desempenho Atlético/fisiologia , Basquetebol/fisiologia , Fadiga/prevenção & controle , Mialgia/prevenção & controle , Meias de Compressão , Adulto , Basquetebol/psicologia , Humanos , Masculino , Fadiga Muscular/fisiologia , Mialgia/fisiopatologia , Percepção , Sono/fisiologia , Adulto Jovem
4.
Bull Cancer ; 107(4): 474-489, 2020 Apr.
Artigo em Francês | MEDLINE | ID: mdl-32061378

RESUMO

After a brief semantic and historical presentation, the article presents the main trials and systematic reviews on the tertiary prevention and care of cancers through physical activity. It gives the keys to understanding how, in forty years of research, interventions dedicated to prevent physical inactivity to reduce the risk of cancer have become as indispensable as adapted physical activity (APA) programs for care pathways. If the public health message "move more" with or without cancer remains true, the research encourages practitioners to implement personalized programs in primary prevention, in addition to treatment and prevention of recurrence. As soon as the diagnosis is made, APA programs will become truly supportive care complementary of treatments, in other words non-pharmacological interventions (NPIs), with the aim of improving the quality of life of patients, improving their overall health, reducing side effects of treatment, potentiate the effects of certain treatments, and reduce the risk of recurrence. Research remains to be carried out notably on the survival, on the advanced cancers and on the integrative modelling of the mechanisms involved.


Assuntos
Exercício Físico , Neoplasias/terapia , Tecido Adiposo , Descondicionamento Cardiovascular , Doenças Cardiovasculares/terapia , Fadiga/prevenção & controle , Humanos , Linfedema/etiologia , Linfedema/prevenção & controle , Recidiva Local de Neoplasia/prevenção & controle , Neoplasias/prevenção & controle , Condicionamento Físico Humano , Prevenção Primária , Qualidade de Vida , Anos de Vida Ajustados por Qualidade de Vida , Prevenção Secundária , Comportamento Sedentário , Prevenção Terciária/métodos , Fatores de Tempo
5.
J Nurs Adm ; 50(2): 66-71, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31929347

RESUMO

A quality improvement process was implemented within a large, tertiary healthcare organization to develop and implement a roundtable culture as part of a fatigue risk management system focused on mitigating nurse leader fatigue and stress. Strategies to form trusting collaboration and reduce leader attrition were initiated and assessed for effectiveness. Results show measurable decreases in reported levels of stress and attrition. Acute, chronic, and persistent fatigue continue to challenge those in leadership roles.


Assuntos
Fadiga/prevenção & controle , Enfermeiras Administradoras/psicologia , Cuidados de Enfermagem/organização & administração , Melhoria de Qualidade/organização & administração , Centros de Atenção Terciária/organização & administração , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
6.
J Sports Sci ; 38(5): 590-596, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31997716

RESUMO

Regular exercise can improve wellbeing, yet data are scarce on how persons with disabling conditions may benefit from active lifestyles, due to the complexities of exercise prescription in this population. A novel medical concept for exercise prescription called activity pacing is the subject of this review, which identifies the potential for this strategy to optimally integrate existing medical and sports medicine approaches in promoting physical activity in persons with disabling conditions. Activity pacing is a goal-directed behavioural process of empowering people to confidently develop decision-making and planning over how and where to distribute available energy across daily activities. Currently, different conceptual traditions and definitions of pacing exist with important implications for the implementation and subsequent effectiveness of activity pacing. Application of activity pacing has mostly focused on symptom-reduction to improve self-regulatory behaviour, and less on physical activity stimulation for health and wellbeing. Further studies and greater connection between medical and sports science research are needed on how to adapt, tailor and optimise activity pacing to make it successful. The potential of activity pacing to increase physical activity and lessen fatigue could be a powerful tool to help fight the growing incidence of physical inactivity, particularly in persons with disabling conditions.


Assuntos
Tomada de Decisões , Pessoas com Deficiência , Exercício Físico , Estilo de Vida , Esportes , Atividades Cotidianas , Fadiga/prevenção & controle , Humanos , Pesquisa , Comportamento Sedentário , Medicina Esportiva , Exacerbação dos Sintomas
7.
Br J Sports Med ; 54(5): 292-297, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30745314

RESUMO

BACKGROUND: Exercise is considered important in the management of patients with rheumatic diseases, but the effect of high intensity exercises on disease activity is unknown. OBJECTIVE: To investigate the effectiveness of high intensity exercises on disease activity in patients with axial spondyloarthritis (axSpA). METHOD: Assessor blinded multicentre randomised controlled trial. 100 patients (aged from their 20s to their 60s) with axSpA were randomly assigned to an exercise group or to a no-intervention control group. The exercise group performed cardiorespiratory and muscular strength exercises at high intensity over 3 months. The control group received standard care and was instructed to maintain their usual physical activity level. Primary outcome was disease activity measured with the Ankylosing Spondylitis (AS) Disease Activity Scale (ASDAS, higher score=worst) and the Bath AS Disease Activity Index (BASDAI, 0-10, 10=worst). Secondary outcomes were inflammatory markers, physical function and cardiovascular (CV)-health. There was patient involvement in the design and reporting of this study. RESULTS: 97 of the 100 (97%) randomised patients completed the measurements after the intervention. There was a significant treatment effect of the intervention on the primary outcome (ASDAS: -0.6 [-0.8 to -0.3], p<0.001 and BASDAI: -1.2 [-1.8 to -0.7], p<0.001). Significant treatment effects were also seen for inflammation, physical function and CV-health. CONCLUSION: High intensity exercises reduced disease symptoms (pain, fatigue, stiffness) and also inflammation in patients with axSpA. It improves patients' function and CV health. This debunks concerns that high intensity exercise might exacerbate disease activity in patients with axSpA. TRIAL REGISTRATION NUMBER: NCT02356874.


Assuntos
Terapia por Exercício/métodos , Treinamento Intervalado de Alta Intensidade , Treinamento de Resistência , Espondilartrite/reabilitação , Adulto , Aptidão Cardiorrespiratória/fisiologia , Progressão da Doença , Terapia por Exercício/efeitos adversos , Fadiga/prevenção & controle , Treinamento Intervalado de Alta Intensidade/efeitos adversos , Humanos , Pessoa de Meia-Idade , Mialgia/prevenção & controle , Dor/prevenção & controle , Treinamento de Resistência/efeitos adversos , Espondilartrite/fisiopatologia , Fatores de Tempo , Adulto Jovem
8.
Food Chem Toxicol ; 135: 111043, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31836553

RESUMO

Tylorrhynchus heterochaetus (Hechong in Chinese) has been used in Chinese traditional medicine for treating various diseases. This study was aimed to assess the anti-fatigue effect of T. heterochaetus on Kunming mice and its primary mechanism of action using forced running, rotating rod and weight-loaded swimming tests. Low (2.70 mg/0.5 mL/20 g), medium (5.41 mg/0.5 mL/20 g) and high (6.58 mg/0.5 mL/20 g) doses of T. heterochaetus aqueous extract were treated to mice for 28 days. Among the doses, the low and medium doses showed significant (p ≤ 0.05) anti-fatigue effect on the weight-loaded swimming test. Also, T. heterochaetus extract showed significant (p ≤ 0.05) effects on fatigue-related blood parameters by increasing the GLU, TG and LDH levels and decreasing the LA, CK and BUN levels. The levels of liver and skeletal muscle glycogen were also significantly (p ≤ 0.05) increased after treatment. Further, on Western blot analysis, it has been found that T. heterochaetus enhanced the expressions of AMPK and PGC-1α in the liver and skeletal muscles of mice. From the study, our outcomes suggest that T. heterochaetus possess an anti-fatigue effect through the AMPK-linked pathway and thereby it can regularize the energy metabolism.


Assuntos
Adenilato Quinase/metabolismo , Produtos Biológicos/farmacologia , Fadiga/prevenção & controle , Poliquetos/química , Animais , Nitrogênio da Ureia Sanguínea , Peso Corporal/efeitos dos fármacos , Creatina Quinase/metabolismo , Glucose/metabolismo , Glicogênio/metabolismo , L-Lactato Desidrogenase/metabolismo , Ácido Láctico/metabolismo , Fígado/metabolismo , Camundongos , Músculo Esquelético/metabolismo , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo , Teste de Desempenho do Rota-Rod , Corrida , Natação , Triglicerídeos/metabolismo
9.
Int J Occup Saf Ergon ; 26(1): 20-36, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30638151

RESUMO

Issues about train driver fatigue are important in the safety of railway systems. This study investigates the subjective perception of fatigue of conventional railway system drivers. The multidimensional Rasch model was used to measure two subjective latent constructs, namely, perceived fatigue awareness and perceived fatigue control. Analytical results show that 21% of the train drivers are unable to control fatigue. Randomly assigned vehicles with various cabin control systems for work shifts is the most unlikely scenario for drivers to perceive and control fatigue. Our results demonstrate that a driver who is unmarried, holds a university degree and has limited driving experience exhibits a low perceived ability to control fatigue. Thus, segmented programs for fatigue risk mitigation should be developed for specific drivers. The findings of this study can help railway safety managers and government regulators in developing and evaluating a management system for driver fatigue risk.


Assuntos
Conscientização , Fadiga/prevenção & controle , Ferrovias , Segurança , Autoeficácia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
10.
Curr Sports Med Rep ; 18(12): 452-457, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31834177

RESUMO

Loss of balance and walking ability are two of the primary impairments in multiple sclerosis (MS), which leads to loss of autonomy, increased fatigue perception, and disease severity in patients. Physical activity has been shown to ameliorate MS functional impairments, but there is limited evidence of synergistic efficacy of exercise training interventions that have both a resistance and aerobic focus in these patients. We evaluated the effect of a 12-wk combined training intervention (resistance and aerobic exercise) on balance, walking ability, fatigue perception, quality of life, and severity of disease in patients with MS. The combined training was well tolerated by the patients and improved the quality of life of the patients as also reflected in the improvement in walking and balance ability as well as reduced depression, fatigue, and severity of disease. The results of this study confirm the beneficial effects of physical activity in patients with MS and support the use of a combination of resistance and aerobic exercise training to achieve functional and psychological therapeutic outcomes.


Assuntos
Terapia por Exercício , Esclerose Múltipla/terapia , Desempenho Físico Funcional , Adulto , Depressão/prevenção & controle , Fadiga/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/psicologia , Projetos Piloto , Equilíbrio Postural , Qualidade de Vida , Treinamento de Resistência , Caminhada
11.
Plast Reconstr Surg ; 144(4): 693e-699e, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31568319

RESUMO

Fatigue is inevitable at all stages of a surgical career. The sustained high degree of concentration required for surgery is complicated by long surgeon working hours and sleep deprivation, which force surgeons to learn to manage and mitigate the effects of physical and mental fatigue on their performance. Extensive evidence exists detailing the potentially dangerous effects of surgeon fatigue on patient safety, but few reports exist offering a comprehensive strategy to mitigate the effects of fatigue on clinical performance. To promote improved detection and mitigation of fatigue among surgeons, the authors have highlighted several deliberate fatigue-management techniques that they have found to be particularly effective in their own experiences. These techniques include proper planning to maximize team efficiency, and the use of scheduled and unscheduled intraoperative breaks for mental and physical rest and regeneration. The decision to take a much-needed break is often neglected because of concerns about prolonging the duration of an operation; with proper self-awareness of fatigue and brief mental checks during natural intraoperative slowdowns, however, the surgeon can quickly assess the need for a much-needed moment of recovery. The authors hope surgeons will find the fatigue-mitigation strategies presented here to be helpful in promoting both their own wellness and the safety and wellness of their patients.


Assuntos
Fadiga/prevenção & controle , Cirurgia Geral , Doenças Profissionais/prevenção & controle , Humanos
12.
Eur J Oncol Nurs ; 42: 103-109, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31479846

RESUMO

PURPOSE: This pilot study aimed to evaluate the effect of an 8-weeks-yoga intervention on quality of life and upper extremity edema volume in women with breast cancer related lymphedema. METHODS: This was a controlled trial with pre-post design. A total of 40 women with breast cancer related lymphedema were randomly assigned into an intervention or control groups. The intervention group participated in a yoga exercise class for 8 weeks, in a twice a week instructor-led practice and once a week home practice. Outcomes were EORTC QLQ_C30 to measure quality of life, and water displacement volume-meter to measure upper extremity edema volume. The outcomes were evaluated at baseline, 4th and 8th week. Data were analyzed using SPSS. RESULTS: Four weeks after the intervention, a significant difference was observed between the groups with respect to role functioning of quality of life (P = 0.03). Eight weeks after the intervention, a significant difference was observed between groups concerning physical and emotional functioning of quality of life (P < 0.05). The changing trend in physical, role, emotional, and cognitive functioning had increased, and in some scales such as fatigue, pain, insomnia, and financial difficulties the scores were reduced in the intervention group. Regarding edema volume, no significant difference was found between both groups on the 4th and 8th week after the intervention (P > 0.05). CONCLUSION: As yoga exercise might improve physical, role, and emotional functioning of quality of life as well as reduce fatigue, pain, and insomnia, using this intervention can be suggested amongst women with breast cancer related lymphedema.


Assuntos
Neoplasias da Mama/psicologia , Neoplasias da Mama/terapia , Linfedema/terapia , Qualidade de Vida , Extremidade Superior , Ioga , Adulto , Neoplasias da Mama/patologia , Fadiga/diagnóstico , Fadiga/etiologia , Fadiga/prevenção & controle , Feminino , Humanos , Linfedema/etiologia , Linfedema/patologia , Pessoa de Meia-Idade , Projetos Piloto , Distúrbios do Início e da Manutenção do Sono/diagnóstico , Distúrbios do Início e da Manutenção do Sono/etiologia , Distúrbios do Início e da Manutenção do Sono/prevenção & controle
13.
NeuroRehabilitation ; 45(2): 187-200, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31498136

RESUMO

BACKGROUND: Daylight entrains the central circadian pacemaker to the 24-hour day and is crucial for optimal alertness and sleep-quality. Rehabilitation patients tend to lack exposure to sufficient natural light. OBJECTIVE: Installed diurnal naturalistic light may reduce the known disrupted sleep quality and fatigue seen in post stroke patients. METHODS: Stroke patients were randomized to either an intervention rehabilitation unit (IU) equipped with naturalistic lighting (artificial sunlight spectrum) or to a control rehabilitation unit (CU) with standard indoor lighting. At inclusion and discharge, fatigue and subjective sleep quality were measured. RESULTS: Ninety stroke patients were included between May 2014, and June 2015. At discharge, patients from the IU experienced less fatigue than the CU patients, based on the Multidimensional Fatigue Inventory questionnaire general (IU, n = 28; CU, n = 30; diff - 20.6%, 95% confidence interval (CI) [- 35.0%; - 3.0%]; P = 0.025) and the Rested Statement (IU, n = 28; CU, n = 30; diff + 41.6%, 95% CI [+4.6%; +91.8%]; P =  0.025). No differences were detected between groups in sleepiness or subjective sleep quality by the Pittsburgh Sleep Quality Index. CONCLUSIONS: Fatigue was significantly reduced in rehabilitation patients exposed to naturalistic lighting during admission.


Assuntos
Fadiga/prevenção & controle , Fototerapia/métodos , Transtornos do Sono-Vigília/terapia , Reabilitação do Acidente Vascular Cerebral/métodos , Acidente Vascular Cerebral/complicações , Luz Solar , Atenção , Ritmo Circadiano , Fadiga/etiologia , Fadiga/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sono , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/prevenção & controle , Vigília
14.
Eur J Cancer Care (Engl) ; 28(4): e13064, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31166038

RESUMO

To explore the effects of home-based music intervention (HBMI) on symptom severity, pain intensity and perceived fatigue among patients with breast cancer. In this randomised controlled trial, patients with breast cancer were randomly assigned into an HBMI or control group. The HBMI group was administered 24-week HBMI involving five 30-min sessions per week. The primary outcome was symptom severity; the secondary outcomes were pain and fatigue. A generalised estimating equation was employed to compare the effects after 6, 12 and 24 weeks of intervention between the two groups. A total of 60 patients were recruited. After 6, 12 and 24 weeks, HBMI significantly reduced symptom severity, pain intensity, overall fatigue, general fatigue, emotional fatigue and vigour (p < 0.05). Additionally, HBMI significantly reduced physical fatigue after 6 (p = 0.003) and 12 (p = 0.013) weeks and mental fatigue after 6 weeks (p = 0.001). After 6, 12 and 24 weeks, HBMI reduced symptom severity, pain intensity and overall fatigue. Furthermore, HBMI instantaneously reduced physical and mental fatigue. We recommend that HBMI be administered to patients with breast cancer to reduce their negative thoughts associated with cancer.


Assuntos
Neoplasias da Mama/reabilitação , Sobreviventes de Câncer/psicologia , Musicoterapia/métodos , Música , Adulto , Idoso , Neoplasias da Mama/psicologia , Dor do Câncer/prevenção & controle , Método Duplo-Cego , Fadiga/prevenção & controle , Feminino , Serviços de Assistência Domiciliar , Humanos , Fadiga Mental/prevenção & controle , Pessoa de Meia-Idade , Medição da Dor , Resultado do Tratamento , Adulto Jovem
15.
PLoS One ; 14(5): e0213704, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31150405

RESUMO

A biofeedback system may objectively identify fatigue and provide an individualized timing plan for micro-breaks. We developed and implemented a biofeedback system based on oculometrics using continuous recordings of eye movements and pupil dilations to moderate fatigue development in its early stages. Twenty healthy young participants (10 males and 10 females) performed a cyclic computer task for 31-35 min over two sessions: 1) self-triggered micro-breaks (manual sessions), and 2) biofeedback-triggered micro-breaks (automatic sessions). The sessions were held with one-week inter-session interval and in a counterbalanced order across participants. Each session involved 180 cycles of the computer task and after each 20 cycles (a segment), the task paused for 5-s to acquire perceived fatigue using Karolinska Sleepiness Scale (KSS). Following the pause, a 25-s micro-break involving seated exercises was carried out whether it was triggered by the biofeedback system following the detection of fatigue (KSS≥5) in the automatic sessions or by the participants in the manual sessions. National Aeronautics and Space Administration Task Load Index (NASA-TLX) was administered after sessions. The functioning core of the biofeedback system was based on a Decision Tree Ensemble model for fatigue classification, which was developed using an oculometrics dataset previously collected during the same computer task. The biofeedback system identified fatigue with a mean accuracy of approx. 70%. Perceived workload obtained from NASA-TLX was significantly lower in the automatic sessions compared with the manual sessions, p = 0.01 Cohen's dz = 0.89. The results give support to the effectiveness of integrating oculometrics-based biofeedback in timing plan of micro-breaks to impede fatigue development during computer work.


Assuntos
Biorretroalimentação Psicológica/métodos , Computadores , Fadiga/prevenção & controle , Movimentos Oculares , Fadiga/diagnóstico , Feminino , Humanos , Masculino , Modelos Estatísticos , Reflexo Pupilar
16.
Trials ; 20(1): 379, 2019 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-31234904

RESUMO

BACKGROUND: The relationship between gut dysbiosis and inflammatory diseases including multiple sclerosis (MS) is presently recognized as an important health issue. It has been established that some bacterial probiotic strains are effective in treating MS. This study will investigate the effect of yeast probiotic Saccharomyces boulardii (SB) supplements on mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in MS patients. METHODS/DESIGN: In this double-blind randomized controlled two-group parallel trial, 50 MS patients who meet the inclusion criteria will be recruited from outpatient settings. They will be randomly allocated to 4 months of daily placebo or the SB probiotic intervention. Blood samples will be taken from each participant at the baseline and after the intervention period to assess inflammation and oxidative stress. The primary endpoint will be the changes in their mental health evaluated by the 28-item General Health Questionnaire. The secondary endpoints include changes in: (1) quality of life, evaluated by the 36-item Short Form Questionnaire, (2) fatigue, evaluated by the Fatigue Severity Scale, (3) pain, evaluated by a visual analogue scale, and (4) serum levels of indices of inflammatory stress (high-sensitivity C-reactive protein) and oxidative stress (malondialdehyde and total antioxidant capacity). Moreover, any adverse events and side effects due to the intervention will be documented. DISCUSSION: There is a need to discover safe and practical methods for managing the symptoms of MS. This trial will gather evidence on the effects of a probiotic. TRIAL REGISTRATION: Iranian Clinical Trial Registry, IRCT20161022030424N1 . Registered on 9 April 2018.


Assuntos
Saúde Mental , Esclerose Múltipla/terapia , Estresse Oxidativo , Probióticos/administração & dosagem , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Saccharomyces boulardii , Adolescente , Adulto , Proteína C-Reativa/análise , Suplementos Nutricionais , Método Duplo-Cego , Fadiga/prevenção & controle , Humanos , Pessoa de Meia-Idade , Esclerose Múltipla/sangue , Esclerose Múltipla/psicologia , Dor/prevenção & controle , Estudos Prospectivos , Adulto Jovem
17.
Asian Pac J Cancer Prev ; 20(6): 1661-1666, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31244285

RESUMO

Background: Cancer-related Fatigue (CRF) is one of the most common complications of acute myeloid leukemia (AML) and its related therapies. It can influence all physical and psychological aspects of the patient's life. Also, it is believed that exercise can improve CRF in patients with cancer. Objective: This study aimed to investigate the effect of the walking exercise program on CRF in patients with AML undergoing chemotherapy. Methods: In this quasi-experimental study with a pre- and post-test design, 50 patients with AML undergoing chemotherapy were selected using a convenience sampling method at a teaching hospital in an urban area of Iran. The intervention included daily 30 minutes of planned walking for ten days. Data was collected using a demographic data form and the Brief Fatigue Inventory, which were filled out before the intervention, and on the fifth and tenth days of the intervention. Findings: Statistically significant differences were reported in the reduction of CRF on the fifth day and tenth day of the intervention (p <0.001). Conclusions: The planned walking intervention can be used as an easy and low-cost method for reducing CRF in patients with leukemia.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Terapia por Exercício , Fadiga/prevenção & controle , Leucemia Mieloide Aguda/tratamento farmacológico , Qualidade de Vida , Caminhada , Adolescente , Adulto , Fadiga/induzido quimicamente , Feminino , Seguimentos , Humanos , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Ensaios Clínicos Controlados não Aleatórios como Assunto , Prognóstico , Adulto Jovem
18.
Gulf J Oncolog ; 1(30): 43-51, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31242981

RESUMO

INTRODUCTION: Cancer related fatigue (CRF) is a problem experienced by head and neck cancer patients, especially those who undergo chemoradiation therapy. CRF may persist for years post chemoradiation therapy and significantly impair their quality of life (QOL). Tualang honey is rich in amino acids, vitamins, minerals and enzymes. It is proven to have anti-inflammatory, antioxidant and anti-tumour properties. As CRF is related to inflammatory mediators, the effects of Tualang Honey may improve CRF. The aim of this study is to determine if Tualang honey has a role in improving CRF and quality of life among head and neck cancer patients post chemoradiation. METHODOLOGY: In this open labelled randomized clinical trial, 40 participants aged between 18 and 65 with head and neck cancer who completed chemotherapy and/or radiotherapy in Hospital USM, Kelantan Malaysia or Hospital Taiping were recruited and randomized into two groups: Tualang honey (experimental) group or Vitamin C (control) group. They were prescribed with either daily oral Tualang honey 20mg or vitamin C tablet 100 mg for 8 weeks. Level of fatigue and quality of life were measured using FACIT-Fatigue and FACT H&N questionnaires at baseline, 4 weeks and 8 weeks. The white cell count and C-reactive protein level were also measured at baseline, 4 weeks and 8 weeks. RESULTS: After four and eight weeks of treatment with Tualang honey or Vitamin C, the fatigue level for experimental group was better than in the control group, and the differences were statistically significant (p<0.05). Statistically significant improvements were seen on quality of life (p<0.05) for the experimental group at week 8, however, no significant improvements were seen in white cell count and C-reactive protein level between control and experimental group. CONCLUSION: Our research provided support for the use of Tualang honey to improve CRF and QOL in head and neck cancer patients post chemotherapy or radiotherapy.


Assuntos
Antioxidantes/uso terapêutico , Quimiorradioterapia/efeitos adversos , Fadiga/prevenção & controle , Neoplasias de Cabeça e Pescoço/terapia , Mel , Qualidade de Vida , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fadiga/etiologia , Feminino , Seguimentos , Humanos , Malásia , Masculino , Pessoa de Meia-Idade , Prognóstico , Adulto Jovem
19.
Apunts, Med. esport (Internet) ; 54(202): 55-64, abr.-jun. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-187682

RESUMO

BACKGROUND: Since the 1980s the role of tryptophan in modulating fatigue has been the subject of debate. According to some models, tryptophan delays the onset of fatigue. Conversely, in other models, this amino acid is implicated in generating fatigue. This study attempts to shed some light on the debate. Method: Ten elite (non-professional) road racing cyclists took part in a double-blind study employing paired data under standardised dietary and training conditions. Each volunteer did two trials, one with tryptophan supplementation (TRP) and the other with placebo (PLB). Various body fuel, plasma amino acid and renal function parameters were analysed in relation to fatigue data obtained using the Borg test. Blood pressure, pupil size and haematocrit values were also monitored. The parameters obtained were used to examine the principal components of fatigue in said test. OBJECTIVE: To confirm that, under test conditions, oral L-tryptophan supplementation has a favourable influence on fatigue perception during exercise. RESULTS: The principal components of fatigue, as reflected by the Borg test in this study, fit the following model: Perception of fatigue attained = 8.406050586 + (0.126275247 * % load intensity) - (0.031521537 * cholesterol mg/dl) + (0.051002322 * HDL cholesterol mg/dl) - (0.017130681 * tryptophan mmol/ml) - (0.004545865 * glycinemmol/ml) + (0.082894085 * methioninemmol/ml) - (Multiple correlation coefficient = 0.90; coefficient of determination R2 = 0.82; adjusted R2 = 0.81; standard error: 1.82; observations: 75). Renal function: Urea: (TRP: 45.6 ± 6.5 mg/dl vs. PLB: 44.1 ± 5.7; p < 0.4); creatinine: (TRP: 90.4 ± 12.0 vs. PLB: 88.4 ± 11.8 mg/dl; p < 0.9); resting pupil size: (TRP: 0.38 ± 0.07 AU vs. PLB: 0.35 ± 0.08 AU; p < 0.01); haematocrit: (TRP: 45.3% ± 1.5% vs. PLB: 46.1% ± 2.6%; p < 0.40). CONCLUSIONS: Higher tryptophan levels reduced the increased subjective perception of fatigue (SPF). In the component analysis the impact of tryptophan was estimated as 4% in our model. Tryptophan supplementation did not affect renal function. Tryptophan supplementation altered pupil size. At the dose used, tryptophan supplementation proved effective for the first 2 h following the last intake of the tryptophan supplement


ANTECEDENTES: Desde los años 80, el papel del triptófano para modular la fatiga ha sido objeto de debate. Con arreglo a algunos modelos, el triptófano demora el inicio de la fatiga. Por el contrario, en otros modelos, dicho aminoácido está implicado en la generación de fatiga. Este estudio trata de arrojar cierta luz al debate. Método: Diez ciclistas de carretera de élite (no profesionales) tomaron parte en un estudio doble ciego utilizando datos pareados en condiciones dietéticas y de entrenamiento. Cada voluntario realizó dos pruebas: una con suplemento de triptófano (TRP) y otra con placebo (PLB). Se analizaron diversos parámetros en cuanto a energéticos corporales, aminoácidos en plasma y función renal, con relación a los datos sobre fatiga obtenidos mediante la prueba de Borg. También se supervisaron los valores de presión arterial, tamaño de la pupila y hematocrito. Los parámetros obtenidos se utilizaron para examinar los componentes principales de la fatiga en dicha prueba. OBJETIVO: Confirmar que, en condiciones de prueba, el suplemento oral de L-triptófano influye favorablemente en la percepción de la fatiga durante el ejercicio. RESULTADOS: Los componentes principales de la fatiga, reflejados en este estudio mediante la prueba de Borg, se ajustaron al modelo siguiente: Percepción de fatiga obtenida = 8,406050586 + (0,126275247 * % intensidad de carga) - (0,031521537 * colesterol mg/dl) + (0,051002322 * HDL colesterol mg/dl) - (0,017130681 * triptófano mmol/ml) - (0,004545865 * glicina mmol/ml) + (0,082894085 * metionina mmol/ml). (Coeficiente de correlación múltiple = 0,9; coeficiente de determinación R2 = 0,82; R2 ajustado = 0,81; error estándar: 1,82; observaciones: 75). Función renal: Urea: (TRP: 45,6 ± 6,5 mg/dl vs PLB: 44,1 ± 5,7; p < 0,4); creatinina: (TRP: 90,4 ± 12 vs. PLB: 88,4 ± 11,8 mg/dl; p < 0,9); tamaño de la pupila en reposo: (TRP: 0,38 ± 0,07 AU vs. PLB: 0,35 ± 0,08 AU; p < 0,01); hematocrito: (TRP: 45,3% ± 1,5% vs. PLB: 46,1% ± 2,6%; p < 0,4). CONCLUSIONES: Los niveles superiores de triptófano redujeron el incremento de percepción subjetiva de la fatiga (SPF). En el análisis de componente, el impacto del triptófano se calculó como un 4% en nuestro modelo. El suplemento de triptófano no afectó a la función renal, pero sí alteró el tamaño de la pupila. A la dosis utilizada, dicho suplemento de triptófano resultó ser efectivo durante las dos primeras horas siguientes a la última ingesta del mismo


Assuntos
Humanos , Adulto Jovem , Triptofano/administração & dosagem , Suplementos Nutricionais , Fadiga/prevenção & controle , Ciclismo/fisiologia , Biomarcadores/sangue , Administração Oral , Fadiga/sangue
20.
Prog Brain Res ; 246: 177-204, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31072561

RESUMO

Research on fatigue often involves foundational research in service of addressing real-world problems. In the research discussed in this paper, we discuss this interplay between basic and applied science to highlight the contributions of basic science to informing policy and decision making to reduce risk and improve safety in this domain. We describe three areas of research-ground combat, flight operations, and fatigue countermeasures-where laboratory studies provide critical evidence regarding the causes and consequences of fatigue in applied settings, and discuss the role of that research in addressing real-world challenges. We close by offering some thoughts on the relationship between basic and applied research in this domain, and the synergistic potential between research on sleep loss and cognitive neuroscience.


Assuntos
Fadiga/prevenção & controle , Doenças Profissionais/prevenção & controle , Privação do Sono/prevenção & controle , Fadiga/psicologia , Humanos , Doenças Profissionais/psicologia , Comportamento de Redução do Risco , Privação do Sono/psicologia , Análise e Desempenho de Tarefas
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