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1.
Zhongguo Zhong Yao Za Zhi ; 45(17): 4273-4276, 2020 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-33164414

RESUMO

"Preventive treatment of disease" is one of the characteristics and advantages of traditional Chinese medicine. It is the most influential theory of traditional Chinese medicine. The core of the theory is "pre-prevention before disease", "prevention of disease from progress" and "prevention of recovery after disease", and the prevention concepts are "prevention of disease from deve-lopment" and "blockage and reversal". Based on the analysis of large numbers of ancient books, we put forward the overall pharmacovigilance theoretical frame that is composed of toxicity cognition, application, prevention and detoxification. With rich prospective prevention, the pharmacovigilance theory of traditional Chinese medicine was the essence of drug use experience in China for thousands of years. It coincides with the idea of preventing disease with precautions and preventing the occurrence of drug-induced diseases. This article intends to consider the theory and practice of pharmacovigilance of Chinese medicine from the "preventive treatment of disease", in order to provide reference for clinical safety medication. It has puts forward the practical measures of pharmacovigilance of traditional Chinese medicine, such as giving medical advice, paying attention to monitoring, preventing biological change, planning for the long term, preventing disease from changing, delaying the disease progress, protecting vital Qi, controlling internal disorder and preventing recurrence. It also indicated that pharmacovigilance of traditional Chinese medicine is an important part of the "preventive treatment of disease", and an important guarantee for the safe and rational use of medicines in clinical practice, which is conducive to protecting and promoting people's health and improving people's quality of life.


Assuntos
Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , China , Medicamentos de Ervas Chinesas/efeitos adversos , Humanos , Farmacovigilância , Estudos Prospectivos , Qualidade de Vida
2.
Drugs Today (Barc) ; 56(9): 609-614, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33025954

RESUMO

The Drug Information Association (DIA) Europe 2020 brought together multiple stakeholders from around the world including regulatory agencies, industry, patients and academia, to discuss the most innovative topics in healthcare. Main subjects covered were regulatory science, data and data standards, clinical safety and pharmacovigilance, translational medicines and science, patient engagement in clinical development, value and access, medical affairs and scientific communication, health policy, and public affairs and legal issues. The meeting, which was initially intended to take place in Brussels, was finally held virtually due to the COVID-19 situation. This report covers some of the sessions held on these 5 days of state-of-the-art topic discussions.


Assuntos
Participação do Paciente , Farmacovigilância , Pesquisa Médica Translacional , Congressos como Assunto , Infecções por Coronavirus , Europa (Continente) , Humanos , Pandemias , Segurança do Paciente , Pneumonia Viral
3.
Br J Radiol ; 93(1115): 20200596, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-32903029

RESUMO

OBJECTIVES: Considering the growing use of imaging modalities and contrast agents, radiologists are prone to encounter adverse drug reactions (ADR). In the current study, we mainly aim to evaluate the knowledge of radiologists regarding pharmacovigilance (PV). Also, we intend to gather information about their previous ADR experiences. Secondarily, we hope to increase the awareness about contrast-medium-related ADRs and attract attention to the importance of properly reporting these ADRs. METHODS: A survey was generated by using an online survey webpage, and the relevant link was e-mailed to radiologists and radiology residents. The survey begins with a short explanation about the study. The second section contains questions about PV knowledge level, and the final section aims to gather information about the experienced ADRs. RESULTS: The survey was completed by 202 participants. 65.3% stated that they were aware of PV. 24.8% of the participants said that they know the national PV program. 97% told that they knew the term ADR. 66.3% of the participants encountered an ADR. 53.7% of them reported these ADRs. 70.8% of them reported these ADRs to a clinician. CONCLUSIONS: Radiologists encounter ADRs almost as frequently as the other doctors. Their awareness about PV is similar with other healthcare professionals. They have fewer information about TUFAM and PvCPs. Radiologists generally prefer to communicate with a clinician about an ADR. Overall condition of radiologists about PV is quite similar with other healthcare professionals and education can improve it, as for the others. ADVANCES IN KNOWLEDGE: Radiologists encounters ADRs almost as frequently as the other doctors. Overall condition of radiologists about PV is quite similar with other healthcare professionals and education can improve it, as for the others.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Internato e Residência , Farmacovigilância , Radiologistas , Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos , Meios de Contraste/efeitos adversos , Humanos , Internato e Residência/estatística & dados numéricos , Radiologistas/estatística & dados numéricos , Inquéritos e Questionários/estatística & dados numéricos
4.
Zhongguo Zhong Yao Za Zhi ; 45(15): 3533-3538, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-32893541

RESUMO

To explore the general characteristics of adverse drug reactions/adverse events(ADR/AE) in patients after using Shujin Jianyao Pills, and explore risk warning signals, this study analyzed 166 cases of ADR/AE reports of Shujin Jianyao Pills collected from 2005 to 2017 based on the National Center for ADR Monitoring spontaneous reporting system(SRS). And the descriptive statistical method was used to analyze general characteristics. The results showed that among the 166 ADR/AE cases, 106 cases were female patients, accounting for 63.86%. Middle-aged and elderly people aged 45 to 64 accounted for the largest proportion(82 cases, 49.40%), which were followed by elderly aged 65 and over(48 cases, 28.91%). ADR/AE involved a wide range of systems and organs, of which skin and its accessories were the most damaged(30 cases, 12.93%), which were followed by systemic damage(27 cases, 11.64%). The top 10 ADR/AE manifestations were rash(15 cases, 6.33%), nausea(14 cases, 5.91%), dizziness(14 cases, 5.91%), abdominal pain(12 cases, 5.06%), pruritus(11 cases, 4.64%), low back pain(11 cases, 4.64%), vomiting(10 cases, 4.22%), hepatocyte damage(9 cases, 3.80%), headache(9 cases, 3.80%), and diarrhea(7 cases, 2.95%). Bayesian confidence propagation neural network(BCPNN) was used to mine the ADR/AE risk early warning signal of Shujin Jianyao Pills, and the propensity score method was used to control the balance of confounding factors. The results suggested warning signs for nausea, diarrhea, rash, and dizziness, vomiting, abdominal pain, headache, liver cell damage. This study provides a basis for the post-marke-ting safety evaluation of Shujin Jianyao Pills, and can provide guidance for its rational clinical use and risk management.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Medicamentos de Ervas Chinesas , Sistemas de Notificação de Reações Adversas a Medicamentos , Idoso , Teorema de Bayes , Feminino , Humanos , Pessoa de Meia-Idade , Farmacovigilância , Gestão de Riscos
5.
Food Chem Toxicol ; 145: 111767, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32971210

RESUMO

Currently, coronavirus disease 2019 (COVID-19), has posed an imminent threat to global public health. Although some current therapeutic agents have showed potential prevention or treatment, a growing number of associated adverse events have occurred on patients with COVID-19 in the course of medical treatment. Therefore, a comprehensive assessment of the safety profile of therapeutic agents against COVID-19 is urgently needed. In this study, we proposed a network-based framework to identify the potential side effects of current COVID-19 drugs in clinical trials. We established the associations between 116 COVID-19 drugs and 30 kinds of human tissues based on network proximity and gene-set enrichment analysis (GSEA) approaches. Additionally, we focused on four types of drug-induced toxicities targeting four tissues, including hepatotoxicity, renal toxicity, lung toxicity, and neurotoxicity, and validated our network-based predictions by preclinical and clinical evidence available. Finally, we further performed pharmacovigilance analysis to validate several drug-tissue toxicities via data mining adverse event reporting data, and we identified several new drug-induced side effects without labeling in Food and Drug Administration (FDA) drug instructions. Overall, this study provides forceful approaches to assess potential side effects on COVID-19 drugs, which will be helpful for their safe use in clinical practice and promoting the discovery of antiviral therapeutics against SARS-CoV-2.


Assuntos
Antineoplásicos/efeitos adversos , Antivirais/efeitos adversos , Infecções por Coronavirus/tratamento farmacológico , Fatores Imunológicos/efeitos adversos , Farmacovigilância , Pneumonia Viral/tratamento farmacológico , Antineoplásicos/uso terapêutico , Antivirais/uso terapêutico , Betacoronavirus/efeitos dos fármacos , Ensaios Clínicos como Assunto , Humanos , Fatores Imunológicos/uso terapêutico , Pandemias
6.
PLoS Negl Trop Dis ; 14(9): e0008370, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32956348

RESUMO

Chagas disease (CD) and tuberculosis (TB) are important health problems in Bolivia. Current treatments for both infections require a long period of time, and adverse drug reactions (ADRs) are frequent. This study aims to strengthen the Bolivian pharmacovigilance system, focusing on CD and TB. A situation analysis of pharmacovigilance in the Department of Cochabamba was performed. The use of a new local case report form (CRF) was implemented, together with the CRF established by the Unidad de Medicamentos y Tecnología en Salud (UNIMED), in several healthcare centers. Training and follow-up on drug safety monitoring and ADR reporting was provided to all health professionals involved in CD and TB treatment. A comparative analysis of the reported ADRs using the CRF provided by UNIMED, the new CRF proposal, and medical records, was also performed. Our results showed that out of all patients starting treatment for CD, 37.9% suffered ADRs according to the medical records, and 25.3% of them were classified as moderate/severe (MS). Only 47.4% of MS ADRs were reported to UNIMED. Regarding TB treatment, 9.9% of all patients suffered ADRs, 44% of them were classified as MS, and 75% of MS ADRs were reported to UNIMED. These findings show that the reinforcement of the Bolivian pharmacovigilance system is an ambitious project that should involve a long-term perspective and the engagement of national health workers and other stakeholders at all levels. Continuity and perseverance are essential to achieve a solid ADR reporting system, improving patient safety, drug efficacy and adherence to treatment.


Assuntos
Sistemas de Notificação de Reações Adversas a Medicamentos/organização & administração , Doença de Chagas/tratamento farmacológico , Farmacovigilância , Tuberculose/tratamento farmacológico , Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos , Bolívia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Pessoal de Saúde/educação , Humanos , Inquéritos e Questionários
9.
Yonsei Med J ; 61(10): 875-879, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32975062

RESUMO

PURPOSE: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period. MATERIALS AND METHODS: The frequency and clinical features of ADRs caused by CBZ and OXC were analyzed using the pharmacovigilance database and spontaneous ADR reporting data of Yonsei University Severance Hospital & Dental Hospital (Seoul, Korea) from January 1, 2010 to January 31, 2020. RESULTS: Among 10419 cases prescribed CBZ and OXC, 204 ADR cases were reported. The incidences of ADRs were 1.8% and 2.2% for CBZ and OXC respectively, with no significant difference (p=0.169). The most common clinical presentations were skin disorders. Female patients had relatively more frequent ADRs than male patients. Although mild skin ADRs were more frequent with OXC, nervous system disorders, general disorders, and hepatobiliary disorders occurred more often with CBZ. There were six reports of severe cutaneous adverse reactions to CBZ, while OXC had none. Both CBZ and OXC caused ADRs at daily doses lower than the recommended initial dose. CONCLUSION: Due to lower incidence of severe ADRs with OXC than CBZ, we suggest OXC as a first-line prescription.


Assuntos
Anticonvulsivantes/efeitos adversos , Carbamazepina/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Oxcarbazepina/efeitos adversos , Adolescente , Adulto , Idoso , Anticonvulsivantes/uso terapêutico , Transtorno Bipolar , Carbamazepina/uso terapêutico , Epilepsia/tratamento farmacológico , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Neuralgia , Oxcarbazepina/uso terapêutico , Farmacovigilância , República da Coreia/epidemiologia , Centros de Atenção Terciária , Adulto Jovem
10.
Revista Digital de Postgrado ; 9(2): 211, ago. 2020.
Artigo em Espanhol | LILACS, LIVECS | ID: biblio-1103439

RESUMO

En años recientes los venezolanos hemos enfrentado problemas de diversa índole con relación a la situación de salud. Entre ellos, problemas en la prescripción y la obtención de medicamentos. En esta publicación se tratarán aspectos importantes para la correcta prescripción y obtención de medicamentos, lo cual, a su vez, debería ser el colofón de la atención médica de primera que siempre ha caracterizado a nuestro país y que hoy, lamentablemente, ha devenido en una situación muy dolorosa. La prescripción y obtención de medicamentos puede verse dificultada por diversos inconvenientes, entre los cuales podemos considerar aquellos que tienen relación con el medicamento propiamente dicho, con el prescriptor y el cliente, con las regulaciones vigentes en nuestro país y con la disponibilidad en los centros autorizados para su venta. Como consecuencia de una prescripción inadecuada y un consumo inapropiado de medicamentos pueden surgir problemas muy serios, entre los cuales habría que destacar, en el campo de los antiinfecciosos, la resistencia bacteriana. Y en el campo de fármacos destinados al tratamiento del dolor, la ansiedad y el insomnio, la posibilidad de adicciones diversas. La prescripción adecuada de medicamentos conlleva la necesidad de conocer, a la par de los efectos beneficiosos y terapéuticos de los mismos, la posibilidad de efectos adversos e interacciones. Todos los prescriptores sanitarios deben conocer los fundamentos de la Farmacovigilancia, la cual permitirá conocer el verdadero balance riesgo-beneficio de los fármacos, por lo cual hacemos una breve mención de la misma al final de esta presentación(AU)


In recent years, Venezuelans have faced various kinds of problems related to the health situation. Among them, problems in prescription and acquisition of medicines. This publication will discuss important aspects for the correct prescription and obtention of medicines, which, in turn, should be the culmination of the excellent medical care that has always characterized our country but that today, unfortunately, has become a very disgraced and sad situation. Prescription and acquisition of medicines can be hindered by various inconveniences, among which we can consider those that are related to the product itself, to the prescriber and the client, to the regulations in force in our country and to the availability in authorized centers for sale. As a result of an inadequate prescription and consumption of medications, very serious problems can arise, among which, in the field of anti-infectives, bacterial resistance should be highlighted. In the field of drugs for the treatment of pain, anxiety and insomnia, the possibility of diverse addictions. Proper prescription of medicaments entails the need to know, along with their beneficial and therapeutic effects, the possibility of adverse effects and interactions. All health prescribers must know the basics of Pharmacovigilance, which allow to know the true risk-benefit balance of drugs, so we make a brief mention of it at the end of this presentation.(AU)


Assuntos
Humanos , Prescrições de Medicamentos/normas , Resistência Microbiana a Medicamentos , Direito à Saúde , Farmacologia Clínica , Especificações Sanitárias , Farmacovigilância
12.
Expert Opin Drug Saf ; 19(11): 1505-1511, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32693646

RESUMO

BACKGROUND: Baricitinib is approved for the treatment of rheumatoid arthritis (RA). The authors retrospectively investigated adverse events (AEs) by data-mining a self-reporting database to better understand toxicities, especially since it has been used during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: A reporting odds ratio (ROR) was used to detect the risk signals from the data in the US Food and Drug Administration (FDA) adverse event reporting system database (FAERS). The definition relied on system organ class (SOCs) and preferred terms (PTs) by the Medical Dictionary for Regulatory Activities (MedDRA). RESULTS: The search retrieved 1,598 baricitinib-associated cases within the reporting period: 86 PTs with significant disproportionality were retained. Infections including 'herpes zoster,' 'oral herpes,' and 'herpes virus infection' were found at a similar rate to those reported in trials, and such events were rare. Reports emerged for several thrombotic adverse events, while these events were also rare. Unexpected safety signals as opportunistic infections were detected. Serious outcomes as death and life-threatening outcomes accounted for 9.76% of the reported cases. CONCLUSIONS: The incidence of these AEs does not appear above the background expected. These data are consistent with routine clinical observations and suggest the importance of pharmacovigilance.


Assuntos
Sistemas de Notificação de Reações Adversas a Medicamentos , Antirreumáticos/efeitos adversos , Azetidinas/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Inibidores de Janus Quinases/efeitos adversos , Farmacovigilância , Sulfonamidas/efeitos adversos , United States Food and Drug Administration , Adulto , Idoso , Idoso de 80 Anos ou mais , Mineração de Dados , Bases de Dados Factuais , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Segurança do Paciente , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Resultado do Tratamento , Estados Unidos , Adulto Jovem
13.
Int J Clin Pharmacol Ther ; 58(10): 543-549, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32631486

RESUMO

OBJECTIVE: Thrombotic microangiopathy (TMA), often described as thrombotic thrombocytopenic purpura (TTP) or hemolytic uremic syndrome (HUS), is clinically problematic because it is life-threatening. However, up-to-date information on drugs inducing TMA is limited in the real-world setting. The purpose of this study was to clarify drugs associated with TMA using a spontaneous reporting system database. MATERIAL AND METHODS: We performed a retrospective pharmacovigilance disproportionality analysis using the Japanese Adverse Drug Event Report (JADER) database. Adverse event reports submitted to the Pharmaceuticals and Medical Devices Agency between 2004 and 2017 were analyzed. The drug-induced TMA, TTP, and HUS signals were estimated using disproportionality analysis with calculation of the reporting odds ratio (ROR) and 95% confidence interval (CI). RESULTS: A total of 3,292 TMA cases were identified. In the overall analysis, approximately half of the TMA cases involved males, and the most patients were in their 60s. Signal scores of TMA were high for ticlopidine hydrochloride (ROR: 16.2, 95% CI: 12.9 - 20.5), busulfan (ROR: 15.2, 95% CI: 11.5 - 20.3), tacrolimus hydrate (ROR: 10.6, 95% CI: 9.59 - 11.8), gemcitabine hydrochloride (ROR: 10.5, 95% CI: 8.96 - 12.2), and cyclosporine (ROR: 8.70, 95% CI: 7.67 - 9.86). As for TTP or HUS, signal scores of TTP and HUS for tacrolimus and cyclosporine were similar; however, those of TTP for ticlopidine and those of HUS for gemcitabine were noteworthy, and other drugs showed varied likelihoods of reporting TTP and HUS. CONCLUSION: Our results should raise physicians' awareness of drugs associated with TMA, but further investigation of these medications is warranted.


Assuntos
Farmacovigilância , Microangiopatias Trombóticas , Feminino , Síndrome Hemolítico-Urêmica , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Púrpura Trombocitopênica Trombótica , Estudos Retrospectivos , Microangiopatias Trombóticas/induzido quimicamente , Microangiopatias Trombóticas/diagnóstico , Microangiopatias Trombóticas/epidemiologia
14.
Stud Health Technol Inform ; 272: 417-420, 2020 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-32604691

RESUMO

While vaccines are intended to protect people from infectious diseases, public confidence in vaccination has evolved as patients have reservation about vaccination, with a major concern about its safety. Social media may help regulatory authorities to better understand opposition to vaccination and make informed decisions for better promotion of vaccines' benefits towards the public. Our objective was to explore French web forums for potential pharmacovigilance signals associated with human papillomavirus infections (HPV) vaccines. Among 138 posts associated with a signal randomly chosen for manual review, 29% were actually adverse drug reactions to the vaccine described in clinical studies, and only 2 were personal experiences. Only 14% of the reviewed posts described positive opinion about the vaccine whereas 46% were neutral and 40% were negative. While few personal experiences of adverse reactions were actually reported by users, our case study showed a large proportion of negative opinions.


Assuntos
Infecções por Papillomavirus , Vacinas contra Papillomavirus , Mídias Sociais , Humanos , Infecções por Papillomavirus/prevenção & controle , Farmacovigilância , Vacinação
15.
Stud Health Technol Inform ; 272: 342-345, 2020 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-32604672

RESUMO

Information Technology (IT) could have a prominent role towards the "Active Pharmacovigilance" (AP) paradigm by facilitating the analysis of potential Adverse Drug Reactions (ADRs). PVClinical project aims to build an IT platform enabling the investigation of potential ADRs in the clinical environment and beyond. In this paper, we outline the respective EU regulatory framework and the related Business Processes (BPs), elaborated based on input from clinicians and PV experts as part of the project's "user requirements analysis" phase, highlighting their potential pivotal role in the design of IT tools aiming to support AP.


Assuntos
Farmacovigilância , Sistemas de Notificação de Reações Adversas a Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Tecnologia da Informação
16.
Stud Health Technol Inform ; 272: 55-58, 2020 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-32604599

RESUMO

The automated detection of adverse events in medical records might be a cost-effective solution for patient safety management or pharmacovigilance. Our group proposed an information extraction algorithm (IEA) for detecting adverse events in neurosurgery using documents written in a natural rich-in-morphology language. In this paper, we challenge to optimize and evaluate its performance for the detection of any extremity muscle weakness in clinical texts. Our algorithm shows the accuracy of 0.96 and ROC AUC = 0.96 and might be easily implemented in other medical domains.


Assuntos
Debilidade Muscular , Processamento de Linguagem Natural , Registros Eletrônicos de Saúde , Humanos , Armazenamento e Recuperação da Informação , Farmacovigilância
17.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2275-2286, 2020 May.
Artigo em Chinês | MEDLINE | ID: covidwho-398785

RESUMO

Because coronavirus disease 2019(COVID-19) is highly contagious and serious, it has posed a major threat to public health worldwide. The curative effects of integrated traditional Chinese medicine and Western medicine in the treatment of COVID-19 have been widely recognized and confirmed. However, medical workers shall pay attention to drug-induced heart injury in clinical application. Based on the guideline from the Diagnosis and Treatment Plans for COVID-19(trial seventh edition), taking the recommended drugs as examples, by Western medicine, traditional Chinese medicine, Chinese herbal injection and integrated traditional Chinese and Western medicine, the study analyzed the basic characteristics of recommended drugs for cardiac injury by means of literature review and bioinformatics methods, and summarized cardiac adverse reactions, toxicity mechanisms, combined pharmacotherapy, special population and drug monitoring, focusing on the clinical manifestations, toxic components, targets and regulatory mechanisms of drug-induced cardiac injury. The findings suggested being vigilant to drug-induced cardiac injury during the treatment of COVID-19, playing the advantages of clinical pharmacists and clinical Chinese pharmacists, improving the knowledge reserve of pharmacovigilance, strengthening the prescription review, medication notification and medication monitoring, promoting rational drug use and paying attention to special populations and high-risk groups. The study aims to provide suggestions and reference for pharmacovigilance and pharmaceutical care for front-line doctors and pharmacists against COVID-19, in order to avoid the occurrence of drug-induced heart injury for patients with COVID-19.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Medicamentos de Ervas Chinesas , Traumatismos Cardíacos , Pandemias , Pneumonia Viral , Cardiotoxicidade , Infecções por Coronavirus/tratamento farmacológico , Traumatismos Cardíacos/induzido quimicamente , Humanos , Medicina Tradicional Chinesa , Farmacovigilância
18.
Stud Health Technol Inform ; 270: 1227-1228, 2020 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-32570592

RESUMO

This poster presents a non-exhaustive study of machine learning classification algorithms on pharmacovigilance data. In this study, we have taken into account the patient's clinical data such as medical history, medications taken and their indications for prescriptions, and the observed side effects. From these elements we determine whether the patient case is considered serious or not. We show the performances of the different algorithms by their precision, recall and accuracy as well as their learning curves.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Humanos , Aprendizado de Máquina , Farmacovigilância
20.
Zhongguo Zhong Yao Za Zhi ; 45(10): 2275-2286, 2020 May.
Artigo em Chinês | MEDLINE | ID: mdl-32495580

RESUMO

Because coronavirus disease 2019(COVID-19) is highly contagious and serious, it has posed a major threat to public health worldwide. The curative effects of integrated traditional Chinese medicine and Western medicine in the treatment of COVID-19 have been widely recognized and confirmed. However, medical workers shall pay attention to drug-induced heart injury in clinical application. Based on the guideline from the Diagnosis and Treatment Plans for COVID-19(trial seventh edition), taking the recommended drugs as examples, by Western medicine, traditional Chinese medicine, Chinese herbal injection and integrated traditional Chinese and Western medicine, the study analyzed the basic characteristics of recommended drugs for cardiac injury by means of literature review and bioinformatics methods, and summarized cardiac adverse reactions, toxicity mechanisms, combined pharmacotherapy, special population and drug monitoring, focusing on the clinical manifestations, toxic components, targets and regulatory mechanisms of drug-induced cardiac injury. The findings suggested being vigilant to drug-induced cardiac injury during the treatment of COVID-19, playing the advantages of clinical pharmacists and clinical Chinese pharmacists, improving the knowledge reserve of pharmacovigilance, strengthening the prescription review, medication notification and medication monitoring, promoting rational drug use and paying attention to special populations and high-risk groups. The study aims to provide suggestions and reference for pharmacovigilance and pharmaceutical care for front-line doctors and pharmacists against COVID-19, in order to avoid the occurrence of drug-induced heart injury for patients with COVID-19.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Medicamentos de Ervas Chinesas , Traumatismos Cardíacos , Pandemias , Pneumonia Viral , Cardiotoxicidade , Infecções por Coronavirus/tratamento farmacológico , Traumatismos Cardíacos/induzido quimicamente , Humanos , Medicina Tradicional Chinesa , Farmacovigilância
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