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1.
Artif Organs ; 46(4): 688-696, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34694655

RESUMO

BACKGROUND: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) support is increasingly used in the management of COVID-19-related acute respiratory distress syndrome (ARDS). However, the clinical decision-making to initiate V-V ECMO for severe COVID-19 still remains unclear. In order to determine the optimal timing and patient selection, we investigated the outcomes of both COVID-19 and non-COVID-19 patients undergoing V-V ECMO support. METHODS: Overall, 138 patients were included in this study. Patients were stratified into two cohorts: those with COVID-19 and non-COVID-19 ARDS. RESULTS: The survival in patients with COVID-19 was statistically similar to non-COVID-19 patients (p = .16). However, the COVID-19 group demonstrated higher rates of bleeding (p = .03) and thrombotic complications (p < .001). The duration of V-V ECMO support was longer in COVID-19 patients compared to non-COVID-19 patients (29.0 ± 27.5 vs 15.9 ± 19.6 days, p < .01). Most notably, in contrast to the non-COVID-19 group, we found that COVID-19 patients who had been on a ventilator for longer than 7 days prior to ECMO had 100% mortality without a lung transplant. CONCLUSIONS: These findings suggest that COVID-19-associated ARDS was not associated with a higher post-ECMO mortality than non-COVID-19-associated ARDS patients, despite longer duration of extracorporeal support. Early initiation of V-V ECMO is important for improved ECMO outcomes in COVID-19 ARDS patients. Since late initiation of ECMO was associated with extremely high mortality related to lack of pulmonary recovery, it should be used judiciously or as a bridge to lung transplantation.


Assuntos
COVID-19 , Oxigenação por Membrana Extracorpórea , Síndrome do Desconforto Respiratório , COVID-19/complicações , COVID-19/terapia , Oxigenação por Membrana Extracorpórea/efeitos adversos , Hemorragia/etiologia , Humanos , Síndrome do Desconforto Respiratório/etiologia , Síndrome do Desconforto Respiratório/terapia , Estudos Retrospectivos , Fatores de Tempo
2.
Forensic Sci Int Genet ; 57: 102661, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35063923

RESUMO

Non-self DNA is normally present on skin due to DNA transfer occurring during daily activities. The understanding of persistence and accumulation of foreign DNA on the neck can assist in the interpretation of DNA evidence collected from an assaulted victim. Establishing the composition and level of non-self DNA present is relevant, especially in cases where the victim cohabits with other individuals, such as partner and children. This study investigated the persistence and accumulation of non-self DNA on the neck, over the course of 24 h. DNA samples were collected from the neck of 20 adult volunteers at three time-points, on two days. The detection of a partner's DNA and DNA from unknown sources was studied in relation to the living arrangement and to the activities performed by each individual. An increased number of non-self alleles were detected over time. Partner's DNA was observed to accumulate during the day and to persist when an individual was absent from the shared home environment. DNA from unknown contributors was found on the neck of individuals that used public transport, attended public spaces and had social interactions. The data acquired from this study will help to increase knowledge on the composition of DNA present on an individual's neck in a daily situation.


Assuntos
Vítimas de Crime , DNA , Adulto , Alelos , Criança , DNA/genética , Humanos , Fatores de Tempo
3.
Braz. j. oral sci ; 21: e225757, jan.-dez. 2022. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1366215

RESUMO

Aim: This study aimed to evaluate the effect of frozen storage on the physical properties of a silicone-based test food material, highly used to evaluate the masticatory performance in research settings. Methods: A total of 1,666 silicone cubes of Optosil Comfort® with 5.6-mm edges were shaped and stored at -18°C. The cubes were subsequently tested for flexural strength (maximum force, displacement, stress, and strain) before breaking (n = 136), changes in weight and size (n = 170), and masticatory performance (n = 1360) at eight timepoints: immediately after cube preparation (baseline, no freezing), and 1, 2, 3 and 4 weeks, and 2, 4 and 6 months after frozen storage. The cubes were thawed 8 h before each assessment. Results: The maximum force, stress, maximum displacement, and deformation values for the cubes were not affected by freezing (P > 0.05). At all of the time points, the cubes exhibited similar weight (P = 0.366) and size (identical values). The masticatory performance for the cubes also showed no differences from baseline through 6 months (P = 0.061). Conclusion: Freezing Optosil Comfort® silicone cubes did not alter the physical and mechanical properties of the material, being suitable to optimize the assessment of masticatory parameters for research purposes


Assuntos
Humanos , Masculino , Adulto , Elastômeros de Silicone , Teste de Materiais/métodos , Propriedades Físicas , Congelamento , Resistência à Flexão , Mastigação , Fatores de Tempo
4.
Enferm Clin (Engl Ed) ; 32 Suppl 1: S14-S22, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35688562

RESUMO

AIM: To explore and describe the experiences of women giving birth in a tertiary public hospital, with special focus on experiences related to humanized care and women's participation in decision making. METHOD: This is a qualitative phenomenological study through semi-structured interviews to postpartum women giving birth in a tertiary hospital between January and May 2017. Data were analysed through content analysis. RESULTS: The two overarching themes emerged were the professional-information dyad and privacy. Subthemes of the first main theme were the therapeutic relationship, decision-making, feeding the baby, procedures, and the time factor. Subthemes of the second topic were the feelings generated by the hospital environment, the delivery room, and the maternity ward. CONCLUSIONS: If the therapeutic relationship is good, technology is not seen as dehumanising but rather as necessary to ensure continuing safety. "Humanising" material resources are not a priority for women in the birth process and are little used. Privacy was experienced as being a particularly intense need, which women called for throughout the healthcare process.


Assuntos
Hospitais , Parto , Feminino , Humanos , Gravidez , Pesquisa Qualitativa , Espanha , Fatores de Tempo
5.
Brain Stimul ; 15(3): 814-821, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35643390

RESUMO

BACKGROUND: While vagus nerve stimulation (VNS) has been in use for over two decades, little professional guidance exists to describe dosing and titration of therapy which is the consequence of a limited amount of evidence developed during the pre-market phase of therapy development. Post-market surveillance of dosing practice has revealed significant deviations from dosing and titration guidance offered by professional societies as well as the manufacturer. OBJECTIVE: This analysis aims to identify a target dose for VNS Therapy in Epilepsy. METHODS: Herein, VNS clinical outcomes are linked to the patient-specific dosing parameters for each study visit (n = 1178 patients). A generalized linear mixed model was built to ascertain the relationship between key stimulation parameters (i.e., Output Current, Pulse Width, Signal Frequency, and Duty Cycle) and clinical response, defined as a 50% or greater reduction in seizure frequency from baseline. Other demographic parameters of interest, such as duration of epilepsy and age at implant, were also explored. RESULTS: A population level target output current and duty cycle for VNS therapy for epilepsy was identified as 1.61 mA and 17.1% duty cycle. Patients with shorter duration of epilepsy were identified to have a higher likelihood to respond to VNS therapy (p < 0.001). While patients who were on the therapy longer were more likely to respond to the therapy, the effect did not interact with the dosing settings - suggesting that patients who have been chronically underdosed may still benefit from achieving the target dose. CONCLUSION: An opportunity exists to improve upon VNS outcomes by aligning clinical practice around this evidence-based target dose.


Assuntos
Epilepsia Resistente a Medicamentos , Epilepsia , Estimulação do Nervo Vago , Epilepsia Resistente a Medicamentos/terapia , Epilepsia/terapia , Frequência Cardíaca , Humanos , Convulsões/terapia , Fatores de Tempo , Resultado do Tratamento
6.
J Neurosci Methods ; 376: 109625, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-35653896

RESUMO

Background Apathy is a common behavioral syndrome that occurs across neurological and psychiatric disorders. An influential theoretical framework defined apathy as the quantitative reduction of self-generated voluntary and purposeful behaviors. There is evidence in the literature of the multidimensional nature of apathy with cognitive, behavioral, and emotional dimensions. To date, apathy has been assessed using various scales and questionnaires. Alternative objective and ecological measurements of apathy are needed. New method We used the ECOCAPTURE protocol and an ethological approach to investigate behavior in bvFTD patients under ecological conditions (a waiting room) while they freely explored a novel environment. Data were collected by behavioral coding from 7-minute video using an ethogram and transformed into behavior time series data. We present an approach considering behavioral kinetics to assess behavior. We aimed to construct a new behavior analysis method, called ECOCAPTURE kinetics, using temporal classification for behavior time series data analysis. To develop our classifier, we retained a nonelastic Euclidian metric, combined with a convolutional approach. Results We applied the ECOCAPTURE kinetics method to a cohort of 20 bvFTD patients and 18 healthy controls. We showed that bvFTD patients can be classified according to their behavioral kinetics into three groups. Each subgroup was characterized by specific behavior disorders and neuropsychological profile. Comparison with Existing Method(s) The ECOCAPTURE kinetics method is different from those of the classical approach of measuring behavior, producing time budgets, frequency of behavior occurrences, or kinematic diagrams. Conclusions This approach can be extended to any behavioral study encoding time.


Assuntos
Apatia , Demência Frontotemporal , Humanos , Testes Neuropsicológicos , Fatores de Tempo
7.
Elife ; 112022 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-35666127

RESUMO

Analyses across imaging modalities allow the integration of complementary spatiotemporal information about brain development, structure, and function. However, systematic atlasing across modalities is limited by challenges to effective image alignment. We combine highly spatially resolved electron microscopy (EM) and highly temporally resolved time-lapse fluorescence microscopy (FM) to examine the emergence of a complex nervous system in Caenorhabditis elegans embryogenesis. We generate an EM time series at four classic developmental stages and create a landmark-based co-optimization algorithm for cross-modality image alignment, which handles developmental heterochrony among datasets to achieve accurate single-cell level alignment. Synthesis based on the EM series and time-lapse FM series carrying different cell-specific markers reveals critical dynamic behaviors across scales of identifiable individual cells in the emergence of the primary neuropil, the nerve ring, as well as a major sensory organ, the amphid. Our study paves the way for systematic cross-modality data synthesis in C. elegans and demonstrates a powerful approach that may be applied broadly.


Assuntos
Caenorhabditis elegans , Imagem Óptica , Animais , Microscopia Eletrônica , Microscopia de Fluorescência/métodos , Imagem Óptica/métodos , Fatores de Tempo
8.
Malar J ; 21(1): 157, 2022 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-35641976

RESUMO

BACKGROUND: In Brazil, malaria is caused mainly by the Plasmodium vivax and Plasmodium falciparum species. Its transmission occurs in endemic and non-endemic areas. Malaria geography in Brazil has retracted and is now concentrated in the North region. The Brazilian Amazon region accounts for 99% of Brazil's cases. Brazil's extra-Amazon region has a high frequency of imported cases and in 2019 presented a mortality rate 123 times higher than the Amazon region. Extra-Amazon cases present risks of reintroduction. This study aims to characterize the epidemiological scenario for malaria in the extra-Amazon region of Brazil from 2011 to 2020 with a two-year forecast. METHODS: Time-series study with description of malaria cases and deaths registered in Brazilian extra-Amazon region from 2011 to 2020. Public data from the Notifiable Diseases Information System (Sinan) and the Mortality Information System (SIM) were used. Descriptive analysis, incidence, and notification rates were calculated. Flow charts analysed the flux between Places of Probable Infection (PI) and places of notification. The prediction model utilized a multiplicative Holt-winters model for trend and seasonality components. RESULTS: A total of 6849 cases were registered. Cases were predominantly white males with 9 to 11 years of education, mostly between 30 and 39 years old. Imported cases accounted for 78.9% of cases. Most frequent occupations for imported cases are related to travelling and tourism activities. Among autochthonous cases, there is a higher frequency of agriculture and domestic economic activities. In the period there were 118 deaths due to malaria, of which 34.7% were caused by P. falciparum infections and 48.3% were not specified. The most intense flows of imported cases are from Amazonas and Rondônia to São Paulo, Rio de Janeiro, and Paraná. The prediction estimates around 611 cases for each of the following two years. CONCLUSION: The time series allows a vast epidemiological visualization with a short-term prediction analysis that supports public health planning. Government actions need to be better directed in the extra-Amazon region so the objective of eliminating malaria in Brazil is achieved. Carrying out quality assessments for information systems and qualifying personnel is advisable. Malaria outside the Amazon region is mainly due to imported cases and delay in diagnosis is associated with a higher fatality rate. Better strategies to diagnose and treat suspected cases can lead to lower risk of deaths and local outbreaks that will be important for achieving malaria elimination in Brazil.


Assuntos
Malária Falciparum , Malária Vivax , Malária , Adulto , Brasil/epidemiologia , Humanos , Malária/epidemiologia , Malária Falciparum/epidemiologia , Malária Vivax/diagnóstico , Masculino , Fatores de Tempo , Estados Unidos
10.
Sensors (Basel) ; 22(11)2022 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-35684703

RESUMO

Deep neural networks are one of the most successful classifiers across different domains. However, their use is limited in safety-critical areas due to their limitations concerning interpretability. The research field of explainable artificial intelligence addresses this problem. However, most interpretability methods align to the imaging modality by design. The paper introduces TimeREISE, a model agnostic attribution method that shows success in the context of time series classification. The method applies perturbations to the input and considers different attribution map characteristics such as the granularity and density of an attribution map. The approach demonstrates superior performance compared to existing methods concerning different well-established measurements. TimeREISE shows impressive results in the deletion and insertion test, Infidelity, and Sensitivity. Concerning the continuity of an explanation, it showed superior performance while preserving the correctness of the attribution map. Additional sanity checks prove the correctness of the approach and its dependency on the model parameters. TimeREISE scales well with an increasing number of channels and timesteps. TimeREISE applies to any time series classification network and does not rely on prior data knowledge. TimeREISE is suited for any usecase independent of dataset characteristics such as sequence length, channel number, and number of classes.


Assuntos
Inteligência Artificial , Redes Neurais de Computação , Fatores de Tempo
11.
BMC Genomics ; 23(1): 405, 2022 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-35643424

RESUMO

BACKGROUND: Tardigrades are microscopic animals that are capable of tolerating extreme environments by entering a desiccated state of suspended animation known as anhydrobiosis. While antioxidative stress proteins, antiapoptotic pathways and tardigrade-specific intrinsically disordered proteins have been implicated in the anhydrobiotic machinery, conservation of these mechanisms is not universal within the phylum Tardigrada, suggesting the existence of overlooked components. RESULTS: Here, we show that a novel Mn-dependent peroxidase is an important factor in tardigrade anhydrobiosis. Through time-series transcriptome analysis of Ramazzottius varieornatus specimens exposed to ultraviolet light and comparison with anhydrobiosis entry, we first identified several novel gene families without similarity to existing sequences that are induced rapidly after stress exposure. Among these, a single gene family with multiple orthologs that is highly conserved within the phylum Tardigrada and enhances oxidative stress tolerance when expressed in human cells was identified. Crystallographic study of this protein suggested Zn or Mn binding at the active site, and we further confirmed that this protein has Mn-dependent peroxidase activity in vitro. CONCLUSIONS: Our results demonstrated novel mechanisms for coping with oxidative stress that may be a fundamental mechanism of anhydrobiosis in tardigrades. Furthermore, localization of these sets of proteins mainly in the Golgi apparatus suggests an indispensable role of the Golgi stress response in desiccation tolerance.


Assuntos
Tardígrados , Animais , Peroxidases/genética , Tardígrados/genética , Fatores de Tempo , Transcriptoma , Raios Ultravioleta/efeitos adversos
12.
Eur J Med Res ; 27(1): 76, 2022 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-35643539

RESUMO

OBJECTIVE: This paper explores the effect of blood sample storage temperature and time on the erythrocyte sedimentation rate (ESR) by using the Weiss method. METHODS: Whole blood samples were collected from 80 patients and diluted 1:9 with sodium citrate solution. Each sample was split into two tubes. Using the Weiss method, ESR was tested within 1 h of collection, and one sample was placed at 4 °C and the other at room temperature (23 ± 2 °C). ESR was then measured at 2, 4, 6, 8, 12, and 24 h. The data were statistically analyzed with consideration for temperature and time. RESULTS: ESR decreased gradually over 6 h at room temperature, but the results were not statistically significant. Similarly, there was no significant difference in the decline of ESR within 8 h at 4 °C. However, ESR results decreased significantly after the samples were stored at room temperature for more than 6 h or at 4 °C for more than 8 h. ESR reduction was lower in the samples stored at 4 °C than in those stored at room temperature over the same time period. CONCLUSION: Blood sample storage temperature and duration can affect the measurement of ESR using the Weiss method. ESR testing should be completed within 4 h of sample collection in clinical work.


Assuntos
Temperatura Corporal , Sedimentação Sanguínea , Humanos , Temperatura , Fatores de Tempo
13.
Methods Enzymol ; 669: 303-331, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35644178

RESUMO

Time resolved spectroscopy provides unique insight into the structure and function of cobalamins. In these experiments, the cobalamin is initially excited by a short "pump" pulse in the UV-visible region and then characterized at some later time using a short "probe" pulse. The emphasis in this chapter is on both UV-visible and X-ray probe pulses, with a particular focus on the unique information provided by the latter. The principles of time-resolved spectroscopy are reviewed, with an emphasis on ultrafast measurements (time scales less than ~10ps) to characterize short-lived cobalamin excited states. Several practical considerations are discussed, with a focus on the technical details that are necessary to obtain high quality, interpretable data. These include sample delivery, polarization, and excitation power. Some of the theoretical approaches to interpreting data are discussed.


Assuntos
Eletrônica , Vitamina B 12 , Análise Espectral , Fatores de Tempo , Raios X
14.
Semin Vasc Surg ; 35(2): 190-199, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35672109

RESUMO

The ability of vascular surgeons and endovascular specialists to treat complex tibial lesions has expanded greatly in recent years with the dissemination of contemporary techniques and the development of new endovascular devices. The number of patients with peripheral artery disease with tibial lesions will only increase going forward, especially with the increasing prevalence of diabetes and renal disease in the aging US population. Although open surgical bypass remains a robust option for treating complex tibial lesions, endovascular approaches are being employed increasingly in the tibial segment, often with promising results. In this review, we will lay out general principles for endovascular treatment of complex tibial lesions, outline the initial procedural approach, discuss options for crossing and treating complex tibial lesions, and review the evidence behind both established and emerging endovascular techniques in this challenging anatomic segment.


Assuntos
Procedimentos Endovasculares , Doença Arterial Periférica , Amputação , Humanos , Isquemia/terapia , Salvamento de Membro , Doença Arterial Periférica/diagnóstico por imagem , Doença Arterial Periférica/cirurgia , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento
15.
Semin Vasc Surg ; 35(2): 210-218, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35672111

RESUMO

The incidence of peripheral artery disease continues to rise worldwide, with a concomitant rise in the subset of patients who manifest with chronic limb-threatening ischemia (CLTI). A mainstay of CLTI treatment is revascularization through open surgical bypass, endovascular therapy, or hybrid approaches combining the two modalities. However, a significant proportion of these patients are considered to have nonreconstructable, or no-option, CLTI. This is related to either significant pedal arterial occlusive disease or lack of a bypass conduit. Deep vein arterialization has been used as a potential treatment option for this cohort of patients. We explore the various described methodologies of deep vein arterialization, including open, hybrid, and totally percutaneous. These studies suggest that deep vein arterialization is a promising treatment paradigm for patients with no-option CLTI, with encouraging results in terms of technical feasibility, wound healing, and ultimately limb salvage. However, further study of appropriate patient selection, standardization of techniques, and long-term follow-up are needed.


Assuntos
Procedimentos Endovasculares , Doença Arterial Periférica , Amputação , Doença Crônica , Procedimentos Endovasculares/efeitos adversos , Humanos , Isquemia/diagnóstico por imagem , Isquemia/cirurgia , Salvamento de Membro , Doença Arterial Periférica/diagnóstico por imagem , Doença Arterial Periférica/cirurgia , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento
17.
Sex Reprod Health Matters ; 30(1): 2079185, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35713504

RESUMO

The COVID-19 pandemic significantly impacted sexual and reproductive health and rights. Nepal implemented a nationwide lockdown in March 2020, limiting population movement and service access. The 36 clinics run by Marie Stopes Nepal (MSN) closed for varying periods at the beginning of lockdown. This study assesses the impact of lockdown and associated clinic closures on abortion services within MSN's network. An interrupted time-series analysis of clinic-level MSN data compared abortion service use in the pre-closure and post-reopening periods, focusing on the following outcomes: number of abortion care visits, proportion of abortion-related visits, gestational age at time of abortion care and demographics of patients accessing abortion care. Subsequent meta-analyses combined clinic-level results to generate outcome-specific pooled effect estimates. As MSN clinics reopened, during ongoing wider lockdown, weekly visits for abortion care decreased by 37% on average, but abortion increased as a proportion of services post-reopening (OR: 1.53) compared with pre-closure, with no evidence of a change in the proportion of higher gestation abortions. The demographic profile of abortion care clients was altered, with post-reopening clients more likely to have completed primary education (OR: 1.54) and be aged 25 years or older (OR: 1.31) compared with pre-closure clients. COVID-19 lockdown and associated clinic closures reduced the absolute number of abortion services provided within MSN's network, impacting the composition of service provision. Reductions in safe abortion and wider SRH access will have wide-ranging consequences, curtailing crucial reproductive rights. Policy-makers must ensure ongoing abortion access to protect rights and ensure access.


Assuntos
COVID-19 , COVID-19/epidemiologia , Controle de Doenças Transmissíveis , Feminino , Humanos , Nepal/epidemiologia , Pandemias , Gravidez , Fatores de Tempo
18.
Rev Fac Cien Med Univ Nac Cordoba ; 79(2): 162-167, 2022 06 06.
Artigo em Espanhol | MEDLINE | ID: mdl-35700464

RESUMO

Objetive: to describe a sample of tracheostomized patients requiring prolonged mechanical ventilation who were admitted to a weaning center, to analyze their evolution and to determine the predictors of weaning failure from mechanical ventilation and of mortality. Design: Design: an observational and retrospective cohort study was carried out, in the period between January 2005 and December 2017. Setting: weaning and rehabilitation center. Patients: all tracheostomized patients requiring mechanical ventilation who were admitted during the study period were included. Of 1027 patients admitted to the respiratory care service, a consecutive sample of 677 patients was analyzed. Main variables of interest: the main variables were mortality and weaning failure from mechanical ventilation. Results: : age older than 70 years (OR 1,461 95% CI 1,016-2,099), a cardiovascular history (OR 1,533 95% CI 1,050-2,237), admission due to respiratory disease (OR 1,538 95% CI 1,001-2,364) and presenting more than 105 days of hospitalization (OR 0,408 95% CI 0,261-0,637) were found as predictors of weaning failure. The predictors of mortality were, age over 70 years (OR 2,116 95% CI 1,491-3,004), history of cerebrovascular accident (OR 1,991 95% CI 1,255-3,158), admission to intensive care due to cardiorespiratory arrest (OR 5,821 95% CI 2,193-15,445) and presenting more than 64 days of hospitalization (OR 1, 63 95% CI 1,116-2,292). Conclusions: The data found in this study manage to describe factors associated with weaning and mortality of patients in a weaning and rehabilitation center.


Objetivos: describir una muestra de pacientes traqueostomizados con requerimiento de ventilación mecánica prolongada que ingresaron a un centro de desvinculación, analizar su evolución y determinar los predictores de fracaso de desvinculación de la ventilación mecánica y de mortalidad. Diseño: se realizó un estudio de cohorte observacional y retrospectivo, en el período comprendido entre enero del 2005 y diciembre del 2017. Ámbito: centro de desvinculación de la ventilación mecánica y de rehabilitación. Pacientes: se incluyeron a todos los pacientes traqueostomizados con requerimiento de ventilación mecánica, que ingresaron durante el periodo de estudio. De 1027 pacientes ingresados al servicio de cuidados respiratorios, se analizó una muestra consecutiva de 677 pacientes. Variables de interés principales: las variables principales fueron mortalidad y falla en la desvinculación de la ventilación mecánica. Resultados: Se encontraron como predictores del fracaso de la desvinculación la edad mayor a 70 años (OR 1.461 IC95% 1.016-2.099), tener antecedentes cardiovasculares (OR 1.533 IC95% 1.050-2.237), motivo de ingreso por afección respiratoria (OR 1.538 IC95% 1.001-2.364) y presentar más de 105 días de internación (OR 0.408 IC95% 0.261-0.637). Los predictores de mortalidad fueron, la edad mayor a 70 años (OR 2.116 IC95% 1.491-3.004), tener como antecedente un accidente cerebro-vascular (OR 1.991 IC95% 1.255-3.158), motivo de ingreso a terapia intensiva por paro cardiorrespiratorio (OR 5.821 IC95% 2.193-15.445) y presentar más de 64 días de internación (OR1.63 IC95% 1.116-2.292). Conclusión: Los datos hallados en este estudio logran describir factores asociados a la desvinculación y mortalidad de los pacientes en un centro de desvinculación.


Assuntos
Respiração Artificial , Humanos , Estudos Retrospectivos , Fatores de Tempo
19.
Yi Chuan ; 44(6): 501-509, 2022 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-35729098

RESUMO

Isoniazid (INH) is a first-line anti-tuberculosis drug which can cause idiosyncratic liver injury, while the underlying mechanisms need to be further elucidated. In this study, we explored the time series gene expression profiling of a hepatocyte cell line under isoniazid treatment. Through cluster analysis and enrichment analysis of differentially expressed genes, we revealed a total of 6 gene clusters and a series of pathways related to hepatotoxicity, and 13 key candidate genes were identified according to the protein-protein interaction (PPI) network analysis and maSigPro analysis. These findings lay a foundation for understanding the mechanisms of isoniazid -induced liver toxicity and provide new target genes for the monitoring and treatment of INH-induced hepatotoxicity in the future.


Assuntos
Doença Hepática Induzida por Substâncias e Drogas , Isoniazida , Antituberculosos/toxicidade , Doença Hepática Induzida por Substâncias e Drogas/genética , Expressão Gênica , Humanos , Isoniazida/metabolismo , Isoniazida/toxicidade , Fígado/metabolismo , Fatores de Tempo
20.
Sci Rep ; 12(1): 10400, 2022 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-35729219

RESUMO

Compared to a stationary pattern, a moving pattern dilates the perception of time. However, when it comes to comparing only moving stimulus, the exact dilation effects are less clear. The time dilation may be attributed to either speed of motion, temporal and spatial frequency, stimulus complexity, or the number of changes in the stimulus pattern. In the present study, we used progress bars and throbbers for inducing impressions of fast and slow "apparent" motions while the speed of motion and distance covered was actually equivalent across all conditions. The results indicate that higher number of steps produced the impression of a faster progression leading to an underestimation of time, whereas a progression in large fewer steps, produced slower apparent progression, creating the illusion of dilated time. We suggest that the perception of time depends on the nature of the stimulus rather than the speed of motion or the distance covered by the stimulus.


Assuntos
Ilusões , Percepção de Movimento , Percepção do Tempo , Humanos , Movimento (Física) , Fatores de Tempo
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