Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 37.813
Filtrar
1.
Stomatologiia (Mosk) ; 99(5): 50-57, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33034177

RESUMO

THE AIM OF THE STUDY: Was to presents the first clinical medium-term (18 months) results of implant-supported rehabilitation using this method in Russia, with the special attention paid to the assessment of the patient's quality of life on the GOHAI scale. MATERIALS AND METHODS: The authors performed a clinical and paraclinical examination of 29 patients (20 women and 9 men). The age of the patients ranged from 47 to 88 (average value - 65.45±9.7). We performed a retrospective analysis of all patients operated from June 2017 till March 2019. The patients filled in GOHAI questionnaires about their state of health and quality of life (before treatment and 6 weeks post-surgery). Patients with one or more anterior teeth present as well as fully edentulous mandibles were included in the study. The antagonist teeth could be presented as complete dentures, natural teeth, or implant-supported fixed restorations. All patients received three Trefoil implants (Nobel Biocare AB) inserted with a torque of at least 35 Ncm. The Trefoil bar (Nobel Biocare AB) was used as the framework of the Trefoil bioengineering structure. Statistical processing of the results was performed using the SPSS 23 software. The t-test for dependent samples was used to compare the results of GOHAI surveys before and after the operation and the following statistical hypotheses were suggested: H0 - the results of the GOHAI survey before the operation do not differ from the results of the GOHAI survey after the operation; H1 - GOHAI pre-op survey results are different from GOHAI post-op survey results. A comparison was made between the GOHAI results before and after surgery in male and female patients using the t-test for independent samples. RESULTS: 29 patients included in this (20 females and 9 males) with the mean age of 65 (range:47-88). The average time of operation (surgical operation, prosthetic stage including dental lab work) the Trefoil technique was 6.18 ± 0.87 hours. With the presence of teeth in the mandible, the operation took longer by an average of 45 minutes. Patients were followed for 15±6 months. No chipping of artificial teeth or fractures of the veneering was observed. The survival rate of restorations was 100%. The implant survival rate was 98.85%. The results of the GOHAI survey after surgery show a significant difference from the results of the pre-op survey. If we analyze the average values for the sample, it can be argued that the average result for the GOHAI survey before the operation (29.86) is significantly lower than the average one for the GOHAI survey after the operation (54.93). CONCLUSION: Preliminary medium-term results of the Trefoil concept for implant-supported rehabilitation of the mandible indicate high patient satisfaction results after 6-18 months of follow-up. It requires a further comprehensive study to obtain data with more patients and over a longer follow-up period.


Assuntos
Lotus , Feminino , Humanos , Masculino , Saúde Bucal , Qualidade de Vida , Estudos Retrospectivos , Federação Russa
2.
Zootaxa ; 4860(4): zootaxa.4860.4.7, 2020 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-33055883

RESUMO

Nine species of the genus Saropogon Loew, 1847 are reviewed. Saropogon aliyevi Sakhvon sp. nov. (Azerbaijan), S. astakhovi Sakhvon sp. nov. (Armenia) and S. tajikistanensis Sakhvon sp. nov. (Tajikistan) are described and illustrated. The distribution of some species is increased. Saropogon pittoproctus Loew, 1873 is recorded from Russia (Kalmykia) for the first time. Records of prey of some of the Saropogon species are presented. An identification key to males of the species is given.


Assuntos
Dípteros , Distribuição Animal , Animais , Ásia Central , Masculino , Federação Russa , Transcaucásia
3.
Zootaxa ; 4790(3): zootaxa.4790.3.1, 2020 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-33056693

RESUMO

The type specimens for names of bee taxa in the genera Halictus Latreille, 1804 and Sphecodes Laterille, 1804 of family Halictidae deposited in the Zoological Institute, Russian Academy of Sciences (St. Petersburg) are reviewed. Name-bearing types of 39 species and subspecies are illustrated and detailed information is provided (taxa include 15 described by F. Morawitz; nine by Yu. Pesenko; eight by P. Blüthgen; five by Yu. Astafurova M. Proshchalykin; and two by E. Eversmann). Lectotypes are designated for Halictus flavocallosus Morawitz, 1894, and H. tataricus Blüthgen, 1933.


Assuntos
Himenópteros , Academias e Institutos , Distribuição Animal , Estruturas Animais , Animais , Abelhas , Federação Russa
4.
Vestn Oftalmol ; 136(5. Vyp. 2): 232-236, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33063970

RESUMO

In modern ophthalmological practice, three types of adhesives are most often used: synthetic (cyanoacrylate), biological (fibrin), and polyethylene glycol. Cyanoacrylate adhesive is very strong and polymerizes quickly, however, is generally more toxic compared to other types of adhesives, especially if applied to highly vascularized tissues. It is also believed to have bacteriostatic activity and suppress progressive stroma lysis within the area of ulceration by inhibiting polymorphonuclear leukocytes that exhibit collagenolytic and proteolytic activity. The article presents a clinical case of effective use of Russian-made cyanoacrylate (sulfacrylate) adhesive for the treatment of corneal perforation in a patient with neurotrophic keratopathy. The use of polymer glue can be an effective, affordable, and safe alternative to other methods of urgent treatment of corneal perforations and deep ulcers, as shown by this case and literature data. Depending on the lesion location and prognosis for vision, the method can be used either independently or become a treatment stage before keratoplasty. The latter would enable delayed transplantation with lower risk of complications.


Assuntos
Perfuração da Córnea , Adesivos Teciduais , Adesivos , Perfuração da Córnea/diagnóstico , Perfuração da Córnea/etiologia , Perfuração da Córnea/terapia , Cianoacrilatos , Humanos , Federação Russa
5.
Zootaxa ; 4821(2): zootaxa.4821.2.2, 2020 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-33056320

RESUMO

In Russia, Kazakhstan, and Central Asia the genus Anaceratagallia includes 14 species from two subgenera; all species except one belong to the nominotypical subgenus and can be classified into four groups according to the structure of male genitalia. The illustrated descriptions for all species are given, with male calling signal oscillograms provided for nine species. Ten new synonyms are established. Comparative investigation of morphological and acoustic characters of Anaceratagallia species showed that small differences in the structure of male genitalia and 2nd abdominal apodemes are not species-specific traits. All species studied in nature appeared to be polyphagous feeding on different species of herbaceous dicotyledons. It is assumed that closely related species within each group of the subgenus Anaceratagallia arose as a result of allopatric speciation and became secondarily sympatric due to subsequent range expansions.


Assuntos
Hemípteros , Distribuição Animal , Estruturas Animais , Animais , Ásia Central , Tamanho Corporal , Cazaquistão , Masculino , Tamanho do Órgão , Federação Russa
6.
Zootaxa ; 4768(1): zootaxa.4768.1.2, 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-33056533

RESUMO

A rhizocephalan parasite of the hermit crab Pagurus minutus Hess, 1865 (Decapoda, Paguridae) is described from Russian waters using morphological and molecular methods. Partial sequences of the mitochondrial cytochrome c oxidase subunit I gene (COI) were used as a genetic marker. We refer this species to Peltogaster reticulata Shiino, 1943 (Rhizocephala, Peltogastridae) based on its morphological description, since genetic data for the species from its type locality are lacking. The species can be distinguished from its known congeners by the reticular pattern of the external cuticle. Peltogaster reticulata is the sister taxon to P. postica Yoshida Osawa, 2011 (in Yoshida et al. 2011), inhabiting the same host in southwestern Japan. The complete larval development of Peltogaster reticulata, including five naupliar and one cypris stage, is described and illustrated using SEM.


Assuntos
Anomuros , Parasitos , Thoracica , Animais , Japão , Federação Russa
7.
Zootaxa ; 4848(1): zootaxa.4848.1.1, 2020 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-33056751

RESUMO

The empidoid flies of the Russian Arctic islands and Svalbard Archipelago are revised including families Empididae (4 genera, 32 species), Hybotidae (2 genera, 3 species) and Brachystomatidae (1 genus, 2 species). The following ten new species are described: Empididae-Empis septentrionalis Shamshev Sinclair sp. nov. (Russia: Wrangel Island); Rhamphomyia (Dasyrhamphomyia) gorodkovi Shamshev, Sinclair Saigusa sp. nov. (Russia: Chukotka mainland, Wrangel Island, Taymyr, Yakutia; USA: Alaska); R. (D.) mallochi Shamshev, Sinclair Saigusa sp. nov. (Canada: Yukon; Russia: Chukotka mainland, Kolyuchin and Wrangel Islands; USA: Alaska); R. (Pararhamphomyia) subfilicauda Shamshev Sinclair sp. nov. (Russia: Wrangel Island); R. (P.) submacrura Shamshev Sinclair sp. nov. (Russia: Wrangel Island); R. (P.) subtenuiterfilata Shamshev Sinclair sp. nov. (Russia: Wrangel Island, Yakutia); R. (P.) wrangeli Shamshev Sinclair sp. nov. (Russia: Wrangel Island); R. sublongiseta Shamshev, Sinclair Saigusa sp. nov. (Canada: Yukon; Russia: Wrangel Island); one species of Rhamphomyia was retained as unnamed due to insufficient material; Hybotidae-Platypalpus septentrionalis Shamshev Sinclair sp. nov. (Russia: Wrangel Island), P. subtectifrons Shamshev Sinclair sp. nov. (Canada: Northwest Territories, Yukon; Russia: Wrangel Island; USA: Alaska). For previously described species a short diagnosis and a habitus photo are provided to enable easier recognition. In addition, a key to the species of Rhamphomyia (Empididae) occurring on the Russia Arctic islands and Svalbard Archipelago is compiled. A lectotype is designated for Rhamphomyia armipes Sack, 1923. The male and the female of R. taimyrensis Frey and R. kaninensis Frey are described for the first time, respectively. Tachypeza sericeipalpis Frey is newly recorded from North America (Canada: Northwest Territories, Nunavut) and first illustration of the male terminalia is provided. Trichoclinocera lapponica (Ringdahl) is recorded for the first time from the territory of Russia.


Assuntos
Dípteros , Distribuição Animal , Estruturas Animais , Animais , Feminino , Ilhas , Masculino , Federação Russa , Svalbard
8.
Zootaxa ; 4838(1): zootaxa.4838.1.5, 2020 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-33056834

RESUMO

This article represents the third (and last) part of the catalogue of ectoparasitic gamasid mites associated with small mammals in Asiatic Russia (Siberia and the Russian Far East). A total of 19 species of the genus Hirstionyssus Fonseca, 1948 are indexed, with data on their taxonomic position, nomenclature, host range, and distribution within the region. As a conclusion, a brief overview of fauna of ectoparasitic gamasid mites parasitising Micromammalia (except bats) of Asiatic Russia is given. In total, 71 mite species belonging to nine genera of three families (Haemogamasidae, Hirstionyssidae, Laelapidae) are recorded and divided among taxonomic and ecological groupings.


Assuntos
Ácaros , Animais , Mamíferos , Federação Russa
9.
Vestn Oftalmol ; 136(5): 129-135, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33056974

RESUMO

The article reviews literature on developmental stages of genome-wide association studies (GWAS) of primary open-angle glaucoma (POAG). This problem is currently developing and one of the most complex in ophthalmology. The article considers main GWAS of POAG and established GWAS-significant polymorphisms associated with the disease. The topic of genome-wide studies of primary open-angle glaucoma will be of certain interest to ophthalmologists, materials on GWAS-significant loci can be used both in the selection of polymorphisms in replicative studies of POAG in various populations of Russia, and to expand ideas about the molecular genetic mechanisms of the development of the disease.


Assuntos
Estudo de Associação Genômica Ampla , Glaucoma de Ângulo Aberto , Predisposição Genética para Doença , Glaucoma de Ângulo Aberto/diagnóstico , Glaucoma de Ângulo Aberto/genética , Humanos , Polimorfismo de Nucleotídeo Único , Federação Russa
10.
Angiol Sosud Khir ; 26(3): 28-36, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33063749

RESUMO

This article presents a review of the literature on studying Cilostazol, a type 3 phosphodiesterase inhibitor, also providing the Russian and foreign statistics on the prevalence of peripheral artery disease. It is underlined that the majority of patients with peripheral artery disease have atherosclerotic lesions in the coronary and cerebral vascular basins. Cilostazol deservedly occupies the first lines in the sections of pharmacotherapy for intermittent claudication in international and Russian consensus documents on peripheral artery disease. The drug has an extensive evidence base for the following pharmacological effects: vasodilating, antiplatelet, endothelial protective, and vasculogenic. Clinical efficacy of Cilostazol was confirmed in 15 randomized clinical trials (3 718 patients with intermittent claudication) studying the use of Cilostazol taken twice daily at doses of 50 mg, 100 mg, and 150 mg as compared with placebo or versus pentoxifylline given in a dose of 400 mg three times daily, with a demonstrable increase in the pain-free walking distance and the maximal walking distance on the background of taking Cilostazol. The drug significantly improves the outcomes of endovascular interventions on arteries of lower extremities, decreasing the incidence of restenosis, prolonging limb survival, and reducing the frequency of major amputations. Many studies addressing the use of Cilostazol in patients with coronary and cerebral atherosclerosis have investigated the effect of the drug as a component of dual antiplatelet therapy (aspirin + Cilostazol) and triple antiplatelet therapy (aspirin + clopidogrel + Cilostazol) after endovascular interventions. The addition of Cilostazol to treatment resulted in a significant decrease in the occurrence of re-stenosis, with no increase in the incidence of haemorrhage. Cilostazol may be recommended for patients with multifocal atherosclerosis and resistance to aspirin and clopidogrel. Also presented in the article are the results of a Russian clinical trial studying comparative efficacy of Cilostazol and pentoxifylline in patients with intermittent claudication.


Assuntos
Cilostazol , Doença Arterial Periférica , Humanos , Claudicação Intermitente/diagnóstico , Claudicação Intermitente/tratamento farmacológico , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/tratamento farmacológico , Federação Russa , Tetrazóis
11.
Zootaxa ; 4772(2): zootaxa.4772.2.8, 2020 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-33055618

RESUMO

The larvae, male and female imagines, and eggs of Cinygmula levanidovi Tshernova Belov 1982 are described based on reared specimens from the Russian Far East. The larvae, female imago and eggs are described and illustrated for the first time. The larva of C. levanidovi is similar to the one of C. hirasana Imanishi, 1935 and C. kurenzovi (Bajkova, 1965). However, it can be distinguished from these species and from all other Far Eastern Cinygmula by the shape of its tergalius I, which has a heart-shape and bears a single short gill filament. Tergalius I of C. hirasana and C. kurenzovi possess a similar shape, but there are no gill filaments on the first and the other tergalii.


Assuntos
Ephemeroptera , Distribuição Animal , Estruturas Animais , Animais , Extremo Oriente , Feminino , Larva , Masculino , Federação Russa
12.
Zootaxa ; 4820(3): zootaxa.4820.3.4, 2020 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-33056057

RESUMO

Daphnia curvirostris species complex is a cladoceran group (Crustacea: Cladocera) with maximum diversity in Eastern Palearctic. To date, several representatives of this complex are known from the Russian Far East. Here we describe a new species of the Daphnia sinevi species group from water bodies of Sakhalin Island. Morphology of its parthenogenetic females is similar to that in D. sinevi from the continental part of Asian Eurasia. However, we found diagnostic traits of D. sakhalinensis sp.nov. in morphology of the second pecten on postabdominal claw, armature of seta 2 on exopodite III, proportions of setae 1/ and 2 length on exopodite V, relative length of male rostrum and structure of the second pecten of male postabdominal claw. This work contributes to our full revision of the D. curvirostris species complex. Separation between continental and Sakhalin populations of D. sinevi group probably happened in Pliocene (about 5 MA) when Sakhalin began to separate from the mainland. However, we cannot exclude a version that populations of D. sakhalinensis sp.nov. appeared as a result of colonization of Sakhalin from the continent and further independent evolution of the island populations.


Assuntos
Cladóceros , Animais , Daphnia , Extremo Oriente , Feminino , Ilhas , Masculino , Federação Russa
13.
Zootaxa ; 4822(1): zootaxa.4822.1.10, 2020 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-33056307

RESUMO

The genus Sinohaplotropis Cao et Yin, 2008 is a valid genus and not a synonym of Haplotropis Saussur, 1888. A new species Sinohaplotropis amurensis sp. nov. is described in this paper from Russia. The new species is similar to Sinohaplotropis erenchuanensis Cao et Yin, 2008, but differs from latter by subgenital plate of male triangular, with large bifurcate apex in dorsal view, pronotum longer reaching first abdominal tergite, top of Kraus` organ narrow and interspace of mesosternum straight in the middle. Type specimen is deposited in the Hebei University, Baoding, Hebei, China.


Assuntos
Ortópteros , Distribuição Animal , Estruturas Animais , Animais , Tamanho Corporal , Masculino , Tamanho do Órgão , Rios , Federação Russa
14.
Zootaxa ; 4810(2): zootaxa.4810.2.10, 2020 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-33055903

RESUMO

An analysis of all available information on the variegated mud-loving beetles (Heteroceridae) of Russia and adjacent countries published in the 2nd edition of the third volume of the Catalogue of Palaearctic Coleoptera is presented. An annotated list based on collections and literature is given of new records and new taxonomic data on 31 species of variegated mud-loving beetles.


Assuntos
Besouros , Animais , Federação Russa
15.
Zootaxa ; 4802(3): zootaxa.4802.3.13, 2020 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-33056053

RESUMO

Chironomids of the Diamesinae subfamily from the Russian Arctic were studied using both morphological characters and molecular data. Adult males of Diamesa urvantsevi sp. nov., D. amplexivirilia Hansen, Arctodiamesa appendiculata (Lundström) from Severnaya Zemlya Archipelago and D. arctica (Boheman), Pseudokiefferiella sp. from Vaigach Island were described, redescribed, annotated and figured. A reference 658 bp barcode sequence from a fragment of the mitochondrial gene cytochrome oxidase I (COI) was used as a tool for species delimitation. For D. arctica (Boheman) and Pseudokiefferiella sp. close DNA barcodes from Norway were performed, which allowed to relate these specimens to the described species. Comparisons with corresponding regions of COI between each described species and close related congeneric species produced K2P genetic distances of 0.11-0.16, values well associated with interspecific variation. Phylogenetic relationships for genera Arctodiamesa Makarchenko and Pseudokiefferiella Zavrel were reconstructed for the first time.


Assuntos
Chironomidae , Animais , Código de Barras de DNA Taxonômico , Ilhas , Masculino , Filogenia , Federação Russa
16.
Zootaxa ; 4820(2): zootaxa.4820.2.4, 2020 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-33056068

RESUMO

A new species Baetis (Rhodobaetis) molecularis sp. nov. is described and illustrated based on larvae and reared adults from the Far East of Russia. The differential diagnosis of this species is provided with regard to other representatives of the subgenus Rhodobaetis Jacob, 2003 from East Palaearctic and Nearctic Regions. A dataset including novel and publicly available COI mtDNA sequences of 16 species of Rhodobaetis has been assembled to provide a reference dataset for DNA barcoding. The comparison between Baetis (Rhodobaetis) molecularis sp. nov. and other species produced K2P genetic distances of 0.201 in average, values well above those associated with intraspecific variation. The closest species was Baetis foemina McDonough with a K2P distance value 0.114. A Bayesian phylogeny of available Rhodobaetis is also provided.


Assuntos
Ephemeroptera , Animais , Teorema de Bayes , Extremo Oriente , Filogenia , Federação Russa
17.
Artigo em Russo | MEDLINE | ID: mdl-33081444

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of tenoten for children in the treatment of specific developmental disorders of academic skills in children of 1-3 grades. MATERIAL AND METHODS: Two hundred and forty children, aged 7-9 years, (Total set, Safety population) with verified specific reading disorder (F81.0), specific spelling disorder (F81.1), specific disorder of arithmetical skills (F81.2), mixed disorder of scholastic skills (F81.3; F81.2+F81.0, or F81.2+F81.1, or F81.2+F81.0+F81.1), diagnosed with the use of logopedic or psychological testing (15-35 scores in Fotekova T.A. and Akhutina T.V. reading and writing tests; 5-15 scores in arithmetical subscale of the Wechsler Intelligence Scale for Children) were enrolled in the study. CT was conducted in 10 clinical centers in Russian Federation in 2015- 2019. Patients were randomized into two groups. The first one (n=122) received tenoten for children in a dose of 1 tablet 3 times a day, the second one (n=118) was administered placebo in the same dosage regimen. The clinical data on 237 children (121 of the tenoten group and 116 of the placebo group) were used for Intention-to-treat efficacy analysis. Data on 220 children (115 of the tenoten group and 105 of the placebo group) were included in Per-protocol analysis. The duration of study was 12 weeks. The mean total academic skills (reading, spelling, and counting) score in groups after 12 weeks of treatment was set as the primary efficacy endpoint. RESULTS: The mean total academic skills score increased by 18.55±15.87 points. The significant total difference between the median changes in the total score in the tenoten and placebo groups was 5 points. There was a trend towards positive changes in reading and spelling mean scores in tests that didn't reach statistical significance due to lack of normal distribution of points in samples. There were 73 adverse events (AEs) in 42 patients of the tenoten group and 95 AEs in 31 children of the placebo group. No serious or severe AEs were registered in the tenoten group. No AEs definitely related to the study treatment were registered. No negative drug interactions were observed in the tenoten group. CONCLUSIONS: Tenoten for children is an effective and safe treatment for specific developmental disorders of academic skills in primary school children. Tenoten for children is well tolerated. The treatment is characterized by a high level of adherence of children and their parents to therapy.


Assuntos
Anticorpos , Criança , Método Duplo-Cego , Humanos , Federação Russa
18.
Artigo em Russo | MEDLINE | ID: mdl-33081447

RESUMO

OBJECTIVE: The article presents the results of the first observational study in the Russian Federation on the efficacy and safety of high doses of uridine monophosphate (150 mg) in combination with choline (the supplement neurouridine) in the treatment of patients with nonspecific low back pain. MATERIAL AND METHODS: The Visual Analogue scale (VAS), the painDETECT questionnaire (PD-Q), the Roland-Morris Low Back Pain and Disability Questionnaire, the Hospital Anxiety and Depression Scale (HADS) and the Pittsburgh Sleep Quality Index were used to assess the efficacy of neurouridin in 50 patients with lower back pain. RESULTS AND CONCLUSION: A conclusion was also made about a greater decrease in the intensity of pain in the main group than in the comparison group, a positive effect of treatment on a decrease in the severity of the neuropathic component of pain was not- ed according to the results of PD-Q, revealing signs of improved functional status according to the analysis of the Roland-Morris low back pain and disability questionnaire.


Assuntos
Dor Lombar , Humanos , Dor Lombar/tratamento farmacológico , Federação Russa , Inquéritos e Questionários
19.
Artigo em Russo | MEDLINE | ID: mdl-33081451

RESUMO

OBJECTIVE: To search for electroencephalographic markers of alexithymia in patients with moderate depression. MATERIAL AND METHODS: Sixty-four right-handed inpatients (20 men and 44 women, mean age 29.3+10.7 years), were studied. The level of alexithymia was assessed by the Russian version of the Toronto Alexithymia Scale (TAS-20-R). Patients were stratified into 4 groups by TAS-20-R scores. Two main groups of 22 patients each included people with high (>60 scores) and low (20-51 scores) levels of alexithymia. Control groups included 10 patients with 60-85 scores and 10 patients with 52-54 scores. Current methods of electroencephalographic analysis were used. RESULTS: Alexithymia in patients with moderate depression is characterized by a restructuring of the integrative activity of the brain detected by electroencephalography at rest. Patients with high alexithymia differ from those with low alexithymia by (1) lower values of the real part of the coherence between the frontal and anterior temporal leads of the left hemisphere in the band 28-30 Hz; (2) lower values of the imaginary part of coherence in the band 11-12 Hz between the posterior temporal and parietal as well as the posterior temporal and occipital cortical zones of the right hemisphere; (3) higher rates of the real part of the coherence between the right frontal and central leads in the frequency ranges 12-14 and 6-7 Hz; (4) large values of the imaginary part of the coherence between the left parietal and right posterior temporal cortex in the band 24-26 Hz; (5) higher values of the square of the coherence modulus between the left frontal and anterior temporal cortical zones in the band 17-18 Hz. CONCLUSION: Large cortical representations with involvement of theta, alpha, beta-1 and beta-2 rhythms can contribute to the pathogenesis of alexithymia.


Assuntos
Sintomas Afetivos , Depressão , Adolescente , Adulto , Sintomas Afetivos/diagnóstico , Encéfalo , Eletroencefalografia , Feminino , Humanos , Masculino , Federação Russa , Adulto Jovem
20.
Artigo em Russo | MEDLINE | ID: mdl-33081454

RESUMO

OBJECTIVE: To evaluate the frequency of C9orf72-associated frontotemporal dementia (FTD) in the Russian population and to study clinical features of GGGGCC-repeat expansion carriers. MATERIAL AND METHODS: Twenty-eight patients with FTD are included in the study: 15 with a behavioral variant of FTD (bvFTD) and 13 with a agrammatic/non-fluent variant of primary progressive aphasia (avPPA). The mean age was 62 years (34-80), the mean disease duration was 4 years (1-10). The positive family history was noted in 46% of cases. DNA diagnosis was performed using repeat-primed polymerase chain reaction. RESULTS: The frequency of the C9orf72 repeat expansion in patients with FTD was 14%, in patients with bvFTD 20%, in patients with avPPA 8%. The mean age of disease onset in the expansion carriers was 63 (55-75) years. The frequency of the C9orf72 repeats expansion in familial FTD cases was 31%, in sporadic cases 7%. bvFTD with parkinsonian syndrome was noted in two out of four cases, bvFTD with amyotrophic lateral sclerosis (ALS) was shown in one case, avPPA with ALS was shown in one case. One female patient with bvFTD with parkinsonian syndrome presented with cognitive fluctuations that required a differential diagnosis with Lewy body disease. CONCLUSION: This is the first study of the genetic structure of FTD in the Russian population. The prevalence and clinical characteristics of C9orf72-associated FTD were defined, in particular, the spectrum of motor symptoms was shown along with behavioral and aphasic disturbances. DNA diagnosis plays an important role in confirming the diagnosis and selection of patients for potential disease-modifying treatment.


Assuntos
Esclerose Amiotrófica Lateral , Demência Frontotemporal , Adulto , Idoso , Idoso de 80 Anos ou mais , Esclerose Amiotrófica Lateral/diagnóstico , Esclerose Amiotrófica Lateral/epidemiologia , Esclerose Amiotrófica Lateral/genética , Proteína C9orf72/genética , Feminino , Demência Frontotemporal/diagnóstico , Demência Frontotemporal/epidemiologia , Demência Frontotemporal/genética , Humanos , Pessoa de Meia-Idade , Proteínas/genética , Federação Russa/epidemiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA