Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 9.947
Filtrar
1.
Altern Ther Health Med ; 26(5): 18-26, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32663177

RESUMO

Context: Yoga as a form of physical activity is growing in popularity. During yoga, individuals interrupt the stress response, which is typically associated with high blood pressure (BP), impaired focus, and high levels of anxiety. Consequently, research into yoga's effects on stress should place a special emphasis upon the interplay of the nervous and cardiovascular systems during yoga practice. Objective: The purpose of this study was to delineate the immediate cardiovascular effects of 12 Hatha yoga poses by means of RR (beat-to-beat) intervals and JT (cardiac repolarization) intervals. Design: The research team designed controlled pilot studies based on half-year periods. Setting: The study took place at the Lithuanian University of Health Sciences in Kaunas, Lithuania. Participants: Participants were women who were long-term yoga practitioners. Three studies occurred: (1) Study 1-10 women with a mean age of 30.1 ± 1.9 years, (2) Study 2-10 women with a mean age of 29.9 ± 1.9 years, and (3) Study 3-22 women with a mean age of 32.9 ± 1.8 years. Intervention: The study examined the acute cardiovascular effects of 12 Hatha yoga poses by means of electrocardiogram parameters. Outcome measures: Anthropometrical and physiological parameters were measured: (1) height and weight; (2) body mass index (BMI); (3) heart rate (HR); (4) systolic and diastolic blood pressure (DBP); and (5) electrocardiogram (ECG) RR and JT intervals. Results: The lowest RR interval value was recorded during the Chaturanga Dandasana, at 456.0 ± 16.5 ms in Study 3, with P < .001 compared to the intervals for all the other poses. Significant differences in the JT interval also emerged during the Chaturanga Dandasana, at 177.3 ± 6.0 ms in Study 3 with P < .001 compared to all the other poses. The next lowest RR interval value was recorded in Study 3 during the Utkatasana, at 569.4 ± 17.6 ms. In the Savasana prior to the program, the RR interval increased in study 1 and decreased in studies 2 and 3. The JT interval in the Savasana prior to the program increased in studies 1 and 2 but decreased in study 3. Conclusions: Healthy women can practice a modified and/or a shorter duration of the Chaturanga Dandasana. Adjustments in the Utkatasana, including having the arms in the prayer position, may help prevent strain to the cardiovascular system. Also, practicing poses with a longer RR interval may aid stress-related health problems.


Assuntos
Fenômenos Fisiológicos Cardiovasculares , Frequência Cardíaca/fisiologia , Meditação , Ioga , Adulto , Pressão Sanguínea , Sistema Cardiovascular , Medicina Baseada em Evidências , Feminino , Humanos , Guias de Prática Clínica como Assunto
2.
Am J Physiol Regul Integr Comp Physiol ; 319(3): R358-R365, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32726156

RESUMO

Studies have shown that early-stage type 1 diabetes mellitus (T1DM) leads to an exaggerated reflex pressor response to both static muscle contraction and tendon stretch. However, whether similar responses are present during dynamic exercise (i.e., intermittent contraction) is not known. Therefore, the purpose of this study was to determine whether T1DM leads to an exaggerated reflex pressor response to intermittent muscle contraction. We measured the exercise pressor reflex in unanesthetized, decerebrated T1DM (50 mg/kg streptozotocin; STZ) and healthy control (CTL) Sprague-Dawley rats by intermittently contracting the hindlimb muscles for 30 s while measuring mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and heart rate (HR). Intermittently contracting the hindlimb muscles evoked exaggerated mean RSNA (STZ: Δ109 ± 21%, n = 4 rats; CTL: Δ61 ± 8%, n = 5 rats, P < 0.05), peak MAP (STZ: Δ32 ± 2 mmHg, n = 9 rats; CTL: Δ12 ± 2 mmHg, n = 6 rats, P < 0.05), blood pressure index (STZ: Δ625 ± 60 mmHg/s, n = 9 rats; CTL: Δ241 ± 46 mmHg/s, n = 6 rats, P < 0.05), and HR (STZ: Δ24 ± 3 beats/min, n = 9 rats; CTL: Δ9 ± 3 beats/min, n = 6 rats, P < 0.05) responses to similar developed tensions (P > 0.05) in T1DM compared with CTL rats. T1DM rats also exhibited exaggerated early-onset sympathetic (onset: 1 s) and pressor (onset: 5 s) responses. These data show that early-stage T1DM leads to an exaggerated pressor reflex evoked by intermittent muscle contraction. The early onset and greater blood pressure index suggest that cardiovascular strain during dynamic exercise may be significantly higher in individuals with T1DM.NEW & NOTEWORTHY This is the first study to provide evidence that early-stage type 1 diabetes mellitus (T1DM) leads to an exaggerated exercise pressor reflex evoked by intermittent muscle contraction, resulting in substantially higher cardiovascular strain. These findings are significant as they indicate that interventions targeting the exercise pressor reflex may work to alleviate the increased cardiovascular strain and overall burden during exercise in T1DM.


Assuntos
Fenômenos Fisiológicos Cardiovasculares , Diabetes Mellitus Tipo 1/fisiopatologia , Contração Muscular/fisiologia , Músculo Esquelético/fisiologia , Condicionamento Físico Animal/fisiologia , Animais , Sistema Cardiovascular , Ratos Sprague-Dawley , Reflexo/fisiologia , Sistema Nervoso Simpático/fisiopatologia
3.
Heart Fail Clin ; 16(3): 283-293, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32503752

RESUMO

The incidence of cardiogenic shock and the utilization of mechanical circulatory support devices are increasing in the US. In this review we discuss the pathophysiology of cardiogenic shock through basic hemodynamic and myocardial energetic principles. We also explore the commonly used platforms for temporary mechanical circulatory support, their advantages, disadvantages and practical considerations relating to implementation and management. It is through the translation of underlying physiological principles that we can attempt to maximize the clinical utility of circulatory support devices and improve outcomes in cardiogenic shock.


Assuntos
Circulação Assistida/instrumentação , Fenômenos Fisiológicos Cardiovasculares , Cuidados Críticos/métodos , Coração Auxiliar , Choque Cardiogênico , Circulação Assistida/métodos , Humanos , Choque Cardiogênico/fisiopatologia , Choque Cardiogênico/terapia , Pesquisa Médica Translacional
4.
J Zoo Wildl Med ; 51(2): 290-296, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32549557

RESUMO

Fourteen lowland nyala (Tragelaphus angasii) in managed care were successfully anesthetized for a total of 17 anesthetic events using either a combination of butorphanol (0.75 ± 0.15 mg/kg), azaperone (0.25 ± 0.05 mg/kg), and medetomidine (0.30 ± 0.06 mg/kg) (BAM) or medetomidine (0.17 ± 0.01 mg/kg), azaperone (0.22 ± 0.02 mg/kg), and alfaxalone (0.52 ± 0.08 mg/kg) (MAA) delivered intramuscularly via dart. Mean time to initial effect, sternal recumbency, lateral recumbency, handling, and intubation were recorded. The nyala were maintained in sternal recumbency with supplemental oxygenation until 60 min after initial injection. Cardiopulmonary effects were recorded every 5 min after handling until reversal. Arterial blood samples were collected every 15 min for analysis. Level of sedation and quality of recovery were scored. Anesthesia was antagonized with atipamezole (at 5 mg per mg of medetomidine) for both protocols and naltrexone (at 2 mg per mg of butorphanol) for the BAM protocol delivered intramuscularly via hand injection. Mean time to extubation, head control, and standing post reversal were recorded. No hyperthermia, acidemia, apnea, or tachycardia occurred; however, animals did display hypoxemia. Two animals in the BAM cohort required supplementation to facilitate handling. These drug combinations provided satisfactory levels of sedation in most cases for safe handling and minor procedures in lowland nyala under managed care.


Assuntos
Anestésicos/administração & dosagem , Animais de Zoológico/fisiologia , Antílopes/fisiologia , Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos , Anestésicos/efeitos adversos , Animais , Azaperona/administração & dosagem , Azaperona/efeitos adversos , Butorfanol/administração & dosagem , Butorfanol/efeitos adversos , Combinação de Medicamentos , Feminino , Masculino , Medetomidina/administração & dosagem , Medetomidina/efeitos adversos , Pregnanodionas/administração & dosagem , Pregnanodionas/efeitos adversos
5.
Arq Bras Cardiol ; 114(5): 805-816, 2020 05 11.
Artigo em Inglês, Português | MEDLINE | ID: covidwho-272115

RESUMO

In face of the pandemic of the novel coronavirus disease 2019 (COVID-19), the management of patients with cardiovascular risk factors and/or disease is challenging. The cardiovascular complications evidenced in patients with COVID-19 derive from several mechanisms, ranging from direct viral injury to complications secondary to the inflammatory and thrombotic responses to the infection. The proper care of patients with COVID-19 requires special attention to the cardiovascular system aimed at better outcomes.


Assuntos
Betacoronavirus , Doenças Cardiovasculares/virologia , Infecções por Coronavirus/complicações , Pessoal de Saúde , Pneumonia Viral/complicações , Reanimação Cardiopulmonar/normas , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/terapia , Fenômenos Fisiológicos Cardiovasculares , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/terapia , Pessoal de Saúde/normas , Coração/fisiopatologia , Humanos , Pandemias , Assistência ao Paciente/normas , Pneumonia Viral/diagnóstico , Pneumonia Viral/terapia , Guias de Prática Clínica como Assunto , Fatores de Risco , Disfunção Ventricular/etiologia
6.
Arq Bras Cardiol ; 114(5): 805-816, 2020 05 11.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32401847

RESUMO

In face of the pandemic of the novel coronavirus disease 2019 (COVID-19), the management of patients with cardiovascular risk factors and/or disease is challenging. The cardiovascular complications evidenced in patients with COVID-19 derive from several mechanisms, ranging from direct viral injury to complications secondary to the inflammatory and thrombotic responses to the infection. The proper care of patients with COVID-19 requires special attention to the cardiovascular system aimed at better outcomes.


Assuntos
Betacoronavirus , Doenças Cardiovasculares/virologia , Infecções por Coronavirus/complicações , Pessoal de Saúde , Pneumonia Viral/complicações , Reanimação Cardiopulmonar/normas , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/terapia , Fenômenos Fisiológicos Cardiovasculares , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/terapia , Pessoal de Saúde/normas , Coração/fisiopatologia , Humanos , Pandemias , Assistência ao Paciente/normas , Pneumonia Viral/diagnóstico , Pneumonia Viral/terapia , Guias de Prática Clínica como Assunto , Fatores de Risco , Disfunção Ventricular/etiologia
7.
J Sport Health Sci ; 9(3): 203-210, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32444145

RESUMO

Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway, which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting macromolecules. Autophagy is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular disease. An in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways, as well as autophagy-dependent beneficial effects of exercise in cardiovascular system.


Assuntos
Autofagia/fisiologia , Fenômenos Fisiológicos Cardiovasculares , Exercício Físico/fisiologia , Doenças Cardiovasculares/prevenção & controle , Homeostase , Humanos , Transdução de Sinais
9.
J Cardiovasc Pharmacol ; 75(6): 526-529, 2020 06.
Artigo em Inglês | MEDLINE | ID: covidwho-75397

RESUMO

Coronavirus disease-2019 (COVID-19) has emerged as a pandemic affecting millions of adults. Severe acute respiratory syndrome coronavirus-2019 (SARS-CoV-2), the causative virus of COVID-19, infects host cells through angiotensin-converting enzyme 2 (ACE2). Preclinical models suggest that ACE2 upregulation confers protective effects in acute lung injury. In addition, renin-angiotensin aldosterone system inhibitors reduce adverse atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease outcomes, but may increase ACE2 levels. We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology, as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy.


Assuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/tratamento farmacológico , Peptidil Dipeptidase A/metabolismo , Pneumonia Viral/tratamento farmacológico , Antagonistas de Receptores de Angiotensina/farmacologia , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Animais , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/fisiopatologia , Fenômenos Fisiológicos Cardiovasculares , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/virologia , Humanos , Antagonistas de Receptores de Mineralocorticoides/farmacologia , Pandemias , Pneumonia Viral/fisiopatologia , Pneumonia Viral/virologia , Sistema Renina-Angiotensina/efeitos dos fármacos
10.
J Cardiovasc Pharmacol ; 75(6): 526-529, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32301766

RESUMO

Coronavirus disease-2019 (COVID-19) has emerged as a pandemic affecting millions of adults. Severe acute respiratory syndrome coronavirus-2019 (SARS-CoV-2), the causative virus of COVID-19, infects host cells through angiotensin-converting enzyme 2 (ACE2). Preclinical models suggest that ACE2 upregulation confers protective effects in acute lung injury. In addition, renin-angiotensin aldosterone system inhibitors reduce adverse atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease outcomes, but may increase ACE2 levels. We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology, as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy.


Assuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/tratamento farmacológico , Peptidil Dipeptidase A/metabolismo , Pneumonia Viral/tratamento farmacológico , Antagonistas de Receptores de Angiotensina/farmacologia , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Animais , Doenças Cardiovasculares/tratamento farmacológico , Doenças Cardiovasculares/fisiopatologia , Fenômenos Fisiológicos Cardiovasculares , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/virologia , Humanos , Antagonistas de Receptores de Mineralocorticoides/farmacologia , Pandemias , Pneumonia Viral/fisiopatologia , Pneumonia Viral/virologia , Sistema Renina-Angiotensina/efeitos dos fármacos
11.
J Sports Sci ; 38(15): 1699-1707, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32321385

RESUMO

This study tested the effect of 8-week endurance and resistance training programmes on cardiovascular stress responses, life stress, and coping. Fifty-two untrained but healthy female students were randomised to an 8-week endurance training, an 8-week resistance training, or a wait list control group. Before and after the training intervention, we assessed the groups' cardiorespiratory fitness (VO2max test), self-reported life stress, coping strategies and cardiovascular reactivity to and recovery from a standardised laboratory stressor. Both endurance and resistance training programmes caused physiological adaptation in terms of increased VO2max after the intervention. For stress and coping parameters, participants in the training groups improved cardiovascular recovery from stress and reported having less stress in their everyday life after the intervention than participants in the control group, while the two training groups did not differ from each other. We did not find any significant differences in heart rate reactivity and coping strategies between the study groups. These results partly support that exercise training has stress-reducing benefits regardless of the type of exercise. Both endurance and resistance exercise activities may be effectively used to improve stress regulation competence while having less impact on changing specific coping strategies.


Assuntos
Adaptação Psicológica/fisiologia , Fenômenos Fisiológicos Cardiovasculares , Resistência Física/fisiologia , Treinamento de Resistência/métodos , Estresse Psicológico/fisiopatologia , Estresse Psicológico/terapia , Teste de Esforço , Feminino , Frequência Cardíaca/fisiologia , Humanos , Percepção/fisiologia , Adulto Jovem
12.
Medicine (Baltimore) ; 99(14): e19672, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32243401

RESUMO

BACKGROUND: Coronary heart disease (CHD) has become the primary cause of heart failure (HF). Wenyang Huoxue method can significantly improve cardiac function in patients with CHD complicated with HF, but it has not been systematically evaluated for efficacy and safety. METHODS: We will search China National Knowledge Infrastructure Database, Wanfang database, China Biomedical Literature Database, China Science Journal Database PubMed, Excerpt Medica Database, and Cochrane library. Clinical trial registrations, potential grey literature, related conference abstracts, and reference lists of identified studies will also be retrieved. The electronic database will be searched for literatures published from January 2000 to September 2019. Based on the heterogeneity test, data integration is performed using a fixed effect model or a random effects model. Changes in total effective rate in cardiac function will be assessed as primary outcome. 6-minute walk test, left ventricular ejection fraction, and plasma brain natriuretic peptide will be assessed as secondary outcomes. RevMan 5.3.5 will be used for meta-analysis. RESULTS: This study will provide a high-quality comprehensive evaluation of the efficacy and safety of Wenyang Huoxue method for treating patients with CHD complicated with HF. CONCLUSIONS: This systematic review will determine whether Wenyang Huoxue method provides evidence for effective intervention in patients with CHD complicated with HF. ETHICS AND DISSEMINATION: This systematic review and meta-analysis of randomized controlled trials does not require ethical recognition, and the results of this paper will be published in an open access, internationally influential academic journal. TRIAL REGISTRATION NUMBER: CRD42016025957.


Assuntos
Fenômenos Fisiológicos Cardiovasculares/efeitos dos fármacos , Doença das Coronárias/tratamento farmacológico , Medicamentos de Ervas Chinesas/farmacologia , Insuficiência Cardíaca/tratamento farmacológico , Doença das Coronárias/complicações , Doença das Coronárias/fisiopatologia , Insuficiência Cardíaca/etiologia , Insuficiência Cardíaca/fisiopatologia , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
13.
Medicine (Baltimore) ; 99(17): e19865, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32332649

RESUMO

The aim of this study was to evaluate the relationship between educational attainment and cardiorespiratory fitness (CRF) as a predictor of metabolic syndrome in a Korean population.In this single-center, retrospective cross-sectional study, 988 healthy adults (601 men and 387 women) who underwent regular health check-up in Seoul St. Mary's Hospital were analyzed. Educational attainment was categorized into 3 groups according to their final grade of educational course: middle or high school (≤12 years of education), college or university (12-16 years of education), and postgraduate (≥16 years of education). CRF was assessed by cardiopulmonary exercise testing, biceps strength, hand grip strength, bioelectrical impedance analysis, and echocardiography. Metabolic syndrome was diagnosed according to the 3rd report of the National Cholesterol Education Program.Among the subjects, 357 (36.1%) had metabolic syndrome. The postgraduate group had significantly higher peak oxygen consumption (VO2), biceps strength, hand grip strength, and peak expiratory flow than other groups (all P < .001). This group showed better left ventricular diastolic function, in terms of deceleration time of mitral inflow, maximal tricuspid valve regurgitation velocity, and left atrial volume index than other groups. Peak VO2 (%) was significantly correlated with all the parameters of metabolic syndrome, including insulin resistance (r = -0.106, P = .002), waist circumference (r = -0.387, P < .001), triglyceride (r = -0.109, P = .001), high density lipoprotein-cholesterol (r = 0.219, P < .001), systolic blood pressure (r = -0.143, P < .001), and diastolic blood pressure (r = -0.177, P < .001). And Peak VO2 (%) was found to be a predictor of metabolic syndrome (adjusted ß = .988, P < .001). However, the level of education was not able to predict metabolic syndrome (postgraduate group; ß = .955, P = .801).Although the postgraduate group had better CRF than other groups, the educational attainment could not exclusively predict metabolic syndrome in this study. Further research is needed to reveal the socioeconomic mechanism of developing metabolic syndrome.


Assuntos
Aptidão Cardiorrespiratória , Escolaridade , Síndrome Metabólica/epidemiologia , Idoso , Fenômenos Fisiológicos Cardiovasculares , Estudos Transversais , Status Econômico , Teste de Esforço , Feminino , Humanos , Masculino , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Consumo de Oxigênio , Pico do Fluxo Expiratório , República da Coreia/epidemiologia , Estudos Retrospectivos
14.
Eur J Clin Microbiol Infect Dis ; 39(7): 1209-1220, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32328850

RESUMO

To analyze the susceptibility of SARS-CoV-2 in pregnancy and the drugs that can be used to treat pregnancy with COVID-19, so as to provide evidence for drug selection in clinic. By reviewing the existing literature, this paper analyzes the susceptibility of pregnant women to virus, especially to SARS-CoV-2, from the aspects of anatomical, reproductive endocrine and immune changes during pregnancy and screens effective and fetal-safe treatments from the existing drugs. The anatomical structure of the respiratory system is changed during pregnancy, and the virus transmitted by droplets and aerosols is more easily inhaled by pregnant women and is difficult to remove. Furthermore, the prognosis is worse after infection when compared with non-pregnancy women. And changes in reproductive hormones and immune systems during pregnancy collectively make them more susceptible to certain infections. More importantly, angiotensin-converting enzyme (ACE)-2, the SARS-CoV-2 receptor, has been proven highly increased during pregnancy, which may contribute to the susceptibility to SARS-CoV-2. When it comes to treatment, specific drugs for COVID-19 have not been found at present, and taking old drugs for new use in treating COVID-19 has become an emergency method for the pandemic. Particularly, drugs that show superior maternal and fetal safety are worthy of consideration for pregnant women with COVID-19, such as chloroquine, metformin, statins, lobinavir/ritonavir, glycyrrhizic acid, and nanoparticle-mediated drug delivery (NMDD), etc. Pregnant women are susceptible to COVID-19, and special attention should be paid to the selection of drugs that are both effective for maternal diseases and friendly to the fetus. However, there are still many deficiencies in the study of drug safety during pregnancy, and broad-spectrum, effective and fetal-safe drugs for pregnant women need to be developed so as to cope with more infectious diseases in the future.


Assuntos
Fenômenos Fisiológicos Cardiovasculares , Infecções por Coronavirus/metabolismo , Pneumonia Viral/metabolismo , Complicações Infecciosas na Gravidez/metabolismo , Gravidez/fisiologia , Fenômenos Fisiológicos Respiratórios , Anti-Inflamatórios/uso terapêutico , Antimaláricos/uso terapêutico , Antivirais/uso terapêutico , Metabolismo Basal , Betacoronavirus/metabolismo , Cloroquina/uso terapêutico , Anormalidades Congênitas/epidemiologia , Infecções por Coronavirus/tratamento farmacológico , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/imunologia , Suscetibilidade a Doenças/imunologia , Suscetibilidade a Doenças/metabolismo , Combinação de Medicamentos , Sistemas de Liberação de Medicamentos , Feminino , Capacidade Residual Funcional , Ácido Glicirrízico/uso terapêutico , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Hipoglicemiantes/uso terapêutico , Interferon Tipo I/uso terapêutico , Lopinavir/uso terapêutico , Metformina/uso terapêutico , Nanopartículas , Consumo de Oxigênio , Pandemias , Peptidil Dipeptidase A/metabolismo , Pneumonia Viral/tratamento farmacológico , Pneumonia Viral/epidemiologia , Pneumonia Viral/imunologia , Gravidez/imunologia , Gravidez/metabolismo , Complicações Infecciosas na Gravidez/tratamento farmacológico , Complicações Infecciosas na Gravidez/epidemiologia , Complicações Infecciosas na Gravidez/imunologia , Progesterona/metabolismo , Prognóstico , Ritonavir/uso terapêutico , Glicoproteína da Espícula de Coronavírus/metabolismo , Natimorto/epidemiologia , Relação Ventilação-Perfusão
15.
Subcell Biochem ; 94: 437-464, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32189311

RESUMO

Von Willebrand factor (VWF) and coagulation factor VIII (FVIII) circulate as a complex in plasma and have a major role in the hemostatic system. VWF has a dual role in hemostasis. It promotes platelet adhesion by anchoring the platelets to the subendothelial matrix of damaged vessels and it protects FVIII from proteolytic degradation. Moreover, VWF is an acute phase protein that has multiple roles in vascular inflammation and is massively secreted from Weibel-Palade bodies upon endothelial cell activation. Activated FVIII on the other hand, together with coagulation factor IX forms the tenase complex, an essential feature of the propagation phase of coagulation on the surface of activated platelets. VWF deficiency, either quantitative or qualitative, results in von Willebrand disease (VWD), the most common bleeding disorder. The deficiency of FVIII is responsible for Hemophilia A, an X-linked bleeding disorder. Here, we provide an overview on the role of the VWF-FVIII interaction in vascular physiology.


Assuntos
Fenômenos Fisiológicos Cardiovasculares , Fator VIII/metabolismo , Fator de von Willebrand/metabolismo , Fator VIII/química , Hemofilia A/metabolismo , Humanos , Doenças de von Willebrand/metabolismo , Fator de von Willebrand/química
16.
Artigo em Inglês | MEDLINE | ID: mdl-32196357

RESUMO

Whole body exercise tolerance is the consummate example of integrative physiological function among the metabolic, neuromuscular, cardiovascular, and respiratory systems. Depending on the animal selected, the energetic demands and flux through the oxygen transport system can increase two orders of magnitude from rest to maximal exercise. Thus, animal models in health and disease present the scientist with flexible, powerful, and, in some instances, purpose-built tools to explore the mechanistic bases for physiological function and help unveil the causes for pathological or age-related exercise intolerance. Elegant experimental designs and analyses of kinetic parameters and steady-state responses permit acute and chronic exercise paradigms to identify therapeutic targets for drug development in disease and also present the opportunity to test the efficacy of pharmacological and behavioral countermeasures during aging, for example. However, for this promise to be fully realized, the correct or optimal animal model must be selected in conjunction with reproducible tests of physiological function (e.g., exercise capacity and maximal oxygen uptake) that can be compared equitably across laboratories, clinics, and other proving grounds. Rigorously controlled animal exercise and training studies constitute the foundation of translational research. This review presents the most commonly selected animal models with guidelines for their use and obtaining reproducible results and, crucially, translates state-of-the-art techniques and procedures developed on humans to those animal models.


Assuntos
Fenômenos Fisiológicos Cardiovasculares , Condicionamento Físico Animal/métodos , Guias de Prática Clínica como Assunto , Comitês de Cuidado Animal , Animais , Modelos Animais de Doenças , Condicionamento Físico Animal/ética , Condicionamento Físico Animal/normas , Especificidade da Espécie
17.
Zhonghua Xin Xue Guan Bing Za Zhi ; 48(1): 66-71, 2020 Jan 24.
Artigo em Chinês | MEDLINE | ID: mdl-32008298

RESUMO

Objective: To investigate the impact of change of ideal cardiovascular behavior and related factors on healthy vascular aging(HVA). Methods: This study was a multi-center cross-sectional survey. Six thousand three hundred and sixteen participants who underwent at least 2 healthy examinations from 2006 to 2015 at 11 hospitals, including Kailuan Hospital and so on, and examined brachial-ankle pulse wave velocity (baPWV) during 2010 and 2016, with available information about cardiovascular behavior and factors were included. The cardiovascular health score (CHS) was calculated. Basic CHS was collected from the first examination. The second CHS derived from the healthy examination in the same year of baPWV examination. Change of cardiovascular health score (ΔCHS) was calculated. Participants were defined into 5 groups according to ΔCHS, namely ΔCHS≤-2 (n=2 166), ΔCHS=-1 (n=1 284), ΔCHS=0 (n=1 187), ΔCHS=1 (n=860), and ΔCHS≥2 (n=819). Participants' characteristics, value of baPWV and proportion of HVA were compared among different groups. Multiple logistic regression analysis was used to investigate the association between ΔCHS and HVA. The ΔCHS was recalculated and included in multiple logistic regression analysis model again after each component of the cardiovascular health metrics was removed separately in order to investigate effects of removal factors on HVA by observing changes in effect values. Results: The percentage of the participants with HVA in the group of ΔCHS≤-2, ΔCHS=-1, ΔCHS=0, ΔCHS=1 and ΔCHS≥2 were 23.3%(505/2 166), 27.8%(357/1 284), 28.7%(341/1 187),31.9%(274/860) and 33.9%(278/819), respectively. After adjustment for age, sex, income, education, alcohol consumption and the basic CHS, a significant positive association between ΔCHS and proportion of participants with HVA was observed (OR=1.50, 95%CI 1.44-1.56). Multiple regression analysis after removing each single cardiovascular behavior or factor showed that the OR value decreased as follow systolic blood pressure (OR=1.04, 95%CI 1.00-1.09), fasting blood glucose (OR=1.14, 95%CI 1.09-1.18), physical exercise (OR=1.16, 95%CI 1.11-1.21), salt intake (OR=1.17, 95%CI 1.12-1.22), body mass index (OR=1.18, 95%CI 1.13-1.23), smoking(OR=1.18, 95%CI 1.13-1.23) and total cholesterol (OR=1.20, 95%CI 1.16-1.24). Conclusion: The improvement of every ideal cardiovascular behavior and factor is associated with the increase of the proportion of HVA population.


Assuntos
Envelhecimento , Doenças Cardiovasculares , Análise de Onda de Pulso , Índice Tornozelo-Braço , Pressão Sanguínea , Índice de Massa Corporal , Fenômenos Fisiológicos Cardiovasculares , Estudos Transversais , Humanos , Fatores de Risco
18.
Int J Sports Med ; 41(5): 285-291, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31975358

RESUMO

To understand better the adaptation response of the cardiovascular system (CVS) to self-contained underwater breathing apparatus (SCUBA) diving, Galectin-3 (Gal-3) and specific CVS biomarkers were measured in plasma of 16 male recreational divers before and after (30 min, 3 and 6 h) diving (total time of 30 min at 30 m depth) undertaken a after long non-dive period. The one-time SCUBA dive caused a significant increase in Gal-3, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin-I (hs-TnI), and myoglobin immediately after diving. Whereas Gal-3 and myoglobin dropped down to the basal levels during the recovery period, NT-proBNP and hs-TnI concentration continued to increase. An immediate increase of vascular endothelial growth factor, detected immediately after diving, was followed by a significant decrease and return to the basal level, 3 and 6 h after diving, respectively. After a significant initial decrease, endothelin-1 increased during the recovery period, but did not return to the basal level. The observed changes in these biomarkers reflect comprehensive, but transient adaptation of CVS and muscular system to the specific environmental conditions during the SCUBA dive. Whether the recurrent activation of these adaption mechanisms due to repetitive dives has positive or negative effects on CVS remains to be elucidated.


Assuntos
Adaptação Fisiológica , Fenômenos Fisiológicos Cardiovasculares , Mergulho/fisiologia , Galectina 3/sangue , Adulto , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Mioglobina/sangue , Peptídeo Natriurético Encefálico/sangue , Fragmentos de Peptídeos/sangue , Troponina I/sangue , Fator A de Crescimento do Endotélio Vascular/sangue
19.
Proc Natl Acad Sci U S A ; 117(4): 2180-2186, 2020 01 28.
Artigo em Inglês | MEDLINE | ID: mdl-31932424

RESUMO

Gravity is one of the most ubiquitous environmental effects on living systems: Cellular and organismal responses to gravity are of central importance to understanding the physiological function of organisms, especially eukaryotes. Gravity has been demonstrated to have strong effects on the closed cardiovascular systems of terrestrial vertebrates, with rapidly responding neural reflexes ensuring proper blood flow despite changes in posture. Invertebrates possess open circulatory systems, which could provide fewer mechanisms to restrict gravity effects on blood flow, suggesting that these species also experience effects of gravity on blood pressure and distribution. However, whether gravity affects the open circulatory systems of invertebrates is unknown, partly due to technical measurement issues associated with small body size. Here we used X-ray imaging, radio-tracing of hemolymph, and micropressure measurements in the American grasshopper, Schistocerca americana, to assess responses to body orientation. Our results show that during changes in body orientation, gravity causes large changes in blood and air distribution, and that body position affects ventilation rate. Remarkably, we also found that insects show similar heart rate responses to body position as vertebrates, and contrasting with the classic understanding of open circulatory systems, have flexible valving systems between thorax and abdomen that can separate pressures. Gravitational effects on invertebrate cardiovascular and respiratory systems are likely to be widely distributed among invertebrates and to have broad influence on morphological and physiological evolution.


Assuntos
Gafanhotos/fisiologia , Gravitação , Adaptação Fisiológica , Animais , Pressão Sanguínea , Tamanho Corporal , Fenômenos Fisiológicos Cardiovasculares , Gafanhotos/crescimento & desenvolvimento , Fenômenos Fisiológicos Respiratórios
20.
Circ Res ; 126(2): 258-279, 2020 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-31944922

RESUMO

Essentially all biological processes fluctuate over the course of the day, observed at cellular (eg, transcription, translation, and signaling), organ (eg, contractility and metabolism), and whole-body (eg, physical activity and appetite) levels. It is, therefore, not surprising that both cardiovascular physiology (eg, heart rate and blood pressure) and pathophysiology (eg, onset of adverse cardiovascular events) oscillate during the 24-hour day. Chronobiological influence over biological processes involves a complex interaction of factors that are extrinsic (eg, neurohumoral factors) and intrinsic (eg, circadian clocks) to cells. Here, we focus on circadian governance of 6 fundamentally important processes: metabolism, signaling, electrophysiology, extracellular matrix, clotting, and inflammation. In each case, we discuss (1) the physiological significance for circadian regulation of these processes (ie, the good); (2) the pathological consequence of circadian governance impairment (ie, the bad); and (3) whether persistence/augmentation of circadian influences contribute to pathogenesis during distinct disease states (ie, the ugly). Finally, the translational impact of chronobiology on cardiovascular disease is highlighted.


Assuntos
Relógios Biológicos , Doenças Cardiovasculares/etiologia , Fenômenos Fisiológicos Cardiovasculares , Animais , Humanos , Miocárdio/metabolismo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA