Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 15.223
Filtrar
1.
Stomatologiia (Mosk) ; 99(3): 57-59, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32608951

RESUMO

Multi-stage therapy of children with congenital diseases of the maxillofacial region requires a multidisciplinary team of specialists coordinated consistently conducted treatment, not only providing a complete reconstruction of the maxillary bones, but also improving the quality of life of children. In our study, it was found that the most significant independent predictors of the total indicator of quality of life are indicators of structures and functions of the maxillofacial region, as well as the level of activity and participation of children in real life situations and the level of parental compliance.


Assuntos
Fenda Labial , Fissura Palatina , Criança , Humanos , Prognóstico , Qualidade de Vida
2.
Shanghai Kou Qiang Yi Xue ; 29(1): 51-54, 2020 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-32524121

RESUMO

PURPOSE: To evaluate the symmetry and stability of nasolabial area of unilateral complete cleft lip (UCCL) after primary repair with the method of rotation descent step by step. METHODS: Thirty patients with UCCL who were operated on were photographed before, 1 week after and 1 year after surgery, the distances from alare point (al), sub alare point (sba), christa phlitri point (cph) and chelion point (ch) to the facial vertical midline (VML) were measured and compared with the opposite side by paired t test. Statistical analysis was performed with SPSS 19.0 software package. RESULTS: There were significant differences in al, sba and cph between the cleft side and non-cleft side before(P<0.05) and 1 week after surgery; significant differences were found in al, sba and ch between the affected and unaffected side (P<0.05); but 1 year after surgery, there was no significant difference between the two sides except sba. After surgery, all the distances from VML were less than those before surgery. There was no significant difference in symmetry rate between 1 week and 1 year after surgery for all the points except sba. CONCLUSIONS: The results indicated that the method of rotation descent step by step is very helpful in reconstruction of lip symmetry, but primary repair can not achieve full recovery of nasal symmetry.


Assuntos
Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Procedimentos Cirúrgicos Reconstrutivos , Face , Humanos , Nariz , Rotação , Resultado do Tratamento
3.
J Appl Oral Sci ; 28: e20190628, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32520078

RESUMO

OBJECTIVE: The study of dental development in individuals born with cleft lip and palate (CLP) serves to determine when orthodontic intervention should start. To evaluate the permanent second molar development in children born with cleft lip and palate according to Demirjian's and Nolla's methods. METHODOLOGY: Out of a total of 513 digital panoramic radiographs, 113 pairs of children aged 3 to 16 years were selected. The exams were from children born with or without cleft lip and palate, of the same sex, with an age difference of up to 30 days. The images were analyzed by three examiners and reliability was checked through intra-examiner agreement by the Kappa test. The data were analyzed by Wilcoxon's and Mann-Whitney tests according to each dataset. RESULTS: The findings indicated delayed development of the permanent second molars in children with CLP (P<0.001). The development of the right permanent second molar was delayed compared to the left molar in children with CLP. Moreover, mandibular teeth showed significantly earlier development than maxillary teeth in both the case and control groups. There was no significant difference in the development of permanent second molars between sexes. CONCLUSION: Children with CLP presented delay in the development of permanent second molars.


Assuntos
Fenda Labial/fisiopatologia , Fissura Palatina/fisiopatologia , Dentição Permanente , Dente Molar/crescimento & desenvolvimento , Adolescente , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Dente Molar/diagnóstico por imagem , Valores de Referência , Fatores Sexuais , Estatísticas não Paramétricas
4.
Chin J Dent Res ; 23(2): 119-130, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32548603

RESUMO

OBJECTIVE: To investigate and characterise the differences between the open chromatin regions of oral and epidermal keratinocytes. METHODS: Human immortalised oral epithelial cell lines (HIOECs) were used as the standard model for oral keratinocytes, and primary normal human epidermal keratinocytes (NHEKs) were chosen as the model for epidermal keratinocytes. Assay for transposase accessible chromatin using sequencing (ATAC-seq) and H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) were used to evaluate the dynamic changes in open chromatin regions and active enhancers during oral keratinocyte differentiation. In silico prediction and dual-luciferase assays were used to evaluate the enriched motifs and maintain enhancer activity in specific enriched HIOECs. Integration and comparison of HIOEC ATAC-seq with NHEK ATAC-seq were used to identify oral keratinocyte-enriched open chromatin regions along with key motifs governing differential enhancer activity. The genomic regulatory elements and GWAS overlap algorithm was used to compare the annotation rate of HIOEC-overlapped craniofacial enhancers with other craniofacial enhancers for orofacial cleft-associated variants. RESULTS: During the differentiation of HIOECs, 14933 open chromatin regions became more accessible. Grainyhead-like (GRHL) and Krüppel-like factor (KLF) motifs were overrepresented in maintaining HIOEC-specific activity. Compared with NHEKs, 16161 open chromatin regions were uniquely accessible in HIOECs. Within these regions, the C/EBP motif governed HIOEC-specific enhancer regulating SOX2 and PITX2, which enhanced oral keratinocyte wound healing. When intersected with human craniofacial super-enhancers, open chromatin regions in HIOECS can better annotate the common variants associated with orofacial cleft. CONCLUSION: The intrinsic differences between the open chromatin regions of human oral and epidermal keratinocytes are directly maintained by a set of transcription factors.


Assuntos
Cromatina , Fenda Labial , Diferenciação Celular , Humanos , Queratinócitos , Fatores de Transcrição/genética
5.
Braz Dent J ; 31(2): 190-196, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32556020

RESUMO

The objectives of pre-surgical orthopedics are to allow surgical repair with minimal tension of the involved tissues and less restriction to the craniofacial growth. The aim of this study was to evaluate the benefits of nasoalveolar model (NAM) as a pre-operative therapy in a patient with bilateral cleft lip and palate followed by labioplasty and palatoplasty. A 15-day-old patient underwent orthopedic treatment with NAM. After pre-operative treatment, retraction of the pre-maxilla was observed with reduction of the fissure. Due to the successful effects of NAM treatment the patient had a one-step surgery for lip correction. Six months later, due to lip pressure the fissure was further decreased. After six months, the patient underwent palatoplasty. Both surgeries contributed to the remaining closure of the fissure, which were reduced by half compared to the end of pre-operative treatment. The uses of NAM as a pre-operative treatment approached the alveolar segments, centralized the pre-maxilla, decreased the cleft palate resulting in a marked improvement of the arch and provide superior surgical results. In addition, it allows the primary repair of the patient's lip with asymmetric bilateral fissure in only one-step surgery; in consequence, it will reduce treatment morbidity and decrease cost of treatment.


Assuntos
Fenda Labial , Fissura Palatina , Seguimentos , Humanos , Lactente , Nariz , Cuidados Pré-Operatórios , Resultado do Tratamento
6.
Codas ; 32(4): e20190152, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32401996

RESUMO

Purpose This study investigated the influence of the cleft type on the appearance of hypernasality after surgical maxillary advancement (MA). Methods Nasality was determined by measurement of nasalance (acoustic correlate of nasality) by nasometry. The study involved analysis of the nasalance scores of 17 individuals with isolated cleft palate (CP), 118 with unilateral cleft lip and palate (UCLP) and 69 with bilateral cleft lip and palate (BCLP), of both sexes, aged 18 to 28 years, after MA. Only individuals with normal nasalance scores indicating balanced resonance before MA were included in this study. Nasometry was performed 3 days before and 15 months after MA, on average. The proportion of patients who presented nasalance scores indicating hypernasality after surgery was calculated by the ANOVA test, and comparison among the different cleft types was evaluated by the chi-square test (p < 0.05). Results No significant difference was found in the proportions of individuals with hypernasality among the cleft types. Conclusion Nasometry showed that the appearance of hypernasality after MA in individuals with cleft palate with or without cleft lip occurred in similar proportions, regardless of the cleft type.


Assuntos
Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Procedimentos Cirúrgicos Ortognáticos/efeitos adversos , Distúrbios da Fala/etiologia , Fala/fisiologia , Insuficiência Velofaríngea/etiologia , Adolescente , Adulto , Fenda Labial/fisiopatologia , Fissura Palatina/fisiopatologia , Feminino , Humanos , Masculino , Maxila/cirurgia , Osteotomia de Le Fort/efeitos adversos , Estudos Retrospectivos , Distúrbios da Fala/fisiopatologia , Medida da Produção da Fala , Insuficiência Velofaríngea/fisiopatologia , Adulto Jovem
7.
Spec Care Dentist ; 40(3): 273-279, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32388857

RESUMO

BACKGROUND: Cleft lip and palate is one of the most common developmental anomalies affecting the craniofacial region leading to an array of problems including the inability to feed properly. OBJECTIVES: This study aimed to compare the effectiveness of specially designed audio-visual module over traditional instructional module in improving the assisted breastfeeding habits. METHODOLOGY: Sixteen patients received training regarding the feeding practices through the traditional instructional method, and 16 subjects received training through audio-visual module. Infants in both the groups received the standard care. These infants were followed up longitudinally for 6 months. During the follow up period, the growth parameters were recorded monthly. The knowledge, attitude, and practices of the mothers regarding feeding practices were assessed using KAP questionnaire. RESULTS: There was significant improvement in the knowledge of the mothers from baseline to 6 months, however, the practices indicated that the mothers belonging to the audio-visual module group showed better understating of the condition and earlier adaptation of the breastfeeding practices. Correspondingly, the growth parameters also showed significant difference. CONCLUSION: The custom-made audio-visual module would help the mothers adapt better to the stressful situation following the birth of the infant affected with cleft lip and palate.


Assuntos
Fenda Labial , Fissura Palatina , Aleitamento Materno , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Lactente , Mães
8.
J Contemp Dent Pract ; 21(2): 152-155, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-32381819

RESUMO

AIM: The study aimed to examine the oral health-related quality of life (OHRQoL) of children with cleft lip and palate who were treated with presurgical nasoalveolar molding (PNAM) and to compare the results to age- and gender-matched controls without cleft lip and palate. MATERIALS AND METHODS: Parents of 51 children with cleft lip and palate who were treated with PNAM were administered a validated Arabic version of the short-form child oral health impact profile (COHIP-SF) and were asked to rate their experience with PNAM. The children with treated cleft lip and palate (study group) were age- and gender-matched to children with no cleft lip and palate (control group). The differences in COHIP-SF domains were compared between groups using the Mann-Whitney U test. RESULTS: The children in the test group had significantly higher COHIP-SF scores than in the test group (p < 0.001). However, there were no significant differences in the oral health (p = 0.532) or the oral function (0.232) domains. There were, however, significant differences in the socioemotional domain (p < 0.001). Most of the parents (86%) of children with cleft lip or palate felt that they would recommend PNAM to other parents. CONCLUSION: While there are no differences in the oral health and functional domains of OHRQoL, children with cleft lip and palate treated with PNAM have significantly lower scores in the socioemotional domain of OHRQoL when compared to age- and gender-matched controls. CLINICAL SIGNIFICANCE: Presurgical nasoalveolar molding does not have any negative impact on the OHRQoL of children with cleft lip and palate.


Assuntos
Fenda Labial , Fissura Palatina , Criança , Humanos , Saúde Bucal , Pais , Cuidados Pré-Operatórios , Qualidade de Vida
9.
Khirurgiia (Mosk) ; (4): 88-94, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32352676

RESUMO

OBJECTIVE: Is to evaluate the advantage of Contractubex gel with regards to influence on vascularisation, pigmentation, thickness, surface size, configuration, and elisticity of postsurgical scars of children (after cheilorinoplasty) in comparison to absence of systematized topical treatment. MATERIAL AND METHODS: Into the prospective, non-interventional, observational, multi-centered, in parallel groups, open, controlled study were included 60 patients aged 2,5 months and older with postsurgical scars after first cheilorinoplasty after 7-14 day after operation. Patients were randomized into 2 groups of 30 patients in each. I group - patients get applications of Contractubex gel 3 times a day (in the morning, in the afternoon, in the evening) in accordance with patient information leaflet. II group - control group with no regular therapy of of postsurgical scars (without treatment or without application of oils and gels with anticsarring action). The period of medicine usage - 9 months and more for each patient, the each patient observation duration is 18 months. RESULTS: After analysis of the primary as well as secondary efficacy criteria (total grade based on POSAS scale, reported by investigator/parent) after 3, 6, 12, 18 months of observation in both groups a positive statistically significant dynamics was registered. At the same time in the Contractubex group results were statistically significantly better than in the control group. Positive dynamics was achieved quickier in the main group than in the contol group and was to observe already after 3 months of therapy, during the whole treatment and observation phase, and after 18 months of therapy. Additionally conducted photodocumentation of postsurgical scar development dynamics in terms of the study confirms positive effect of surgery and absence of visual data regarding keloids or hyperthrophic scars formation in patients in both groups. Adverse events, i. a. pain, itch, burning, long-run hyperemia were not registered during the whole period os study. CONCLUSION: The conducted study has shown high efficacy and safety of Contractubex usage for the treatment of postsurgical scars of children with with congenital cleft lip and palate (from 2,5 months old). The statistically significant advantage of the therapy with Contractubex was demonstrated in comparison with the control group (with no regular topical treatment). The obtained results allow to recommend Contractubex gel as an effective and safe medicine for the treatment of scarring after surgeries for kids directly after sutures removal.


Assuntos
Alantoína/administração & dosagem , Cicatriz/tratamento farmacológico , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Fármacos Dermatológicos/administração & dosagem , Heparina/administração & dosagem , Extratos Vegetais/administração & dosagem , Cicatriz/etiologia , Fenda Labial/complicações , Fissura Palatina/complicações , Combinação de Medicamentos , Géis/administração & dosagem , Humanos , Lactente , Complicações Pós-Operatórias/tratamento farmacológico , Estudos Prospectivos , Resultado do Tratamento
10.
J Clin Pediatr Dent ; 44(2): 116-122, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32271659

RESUMO

Objective: This review analyzes the psychological variables most frequently studied over the last 10 years in children and adolescents with cleft lip/palate (CL/P). Such variables are assumed to be the keys to these patients' psychosocial adjustment. Study design: Articles published from January 2007 to February 2017 were retrieved from PubMed to identify the psychological variables most commonly studied in children and adolescents with CL/P, irrespective of gender or type of cleft. The search terms were "cleft palate" and "psychology", with the operator AND. Results: Of the 324 articles retrieved, 26 met the criteria for inclusion in the review. The psychological variables most extensively studied over the years were children's social functioning, quality of life and ability to cope. Conclusion: While CL/P patients' quality of life was unanimously agreed to be affected, no consensus was found in the literature on social functioning or coping. In addition to the cleft, patient adjustment was reported to be governed by individual variables and mediators. The range of ages most frequently studied was 7 to 16.


Assuntos
Fenda Labial , Fissura Palatina , Adaptação Psicológica , Adolescente , Criança , Humanos , Qualidade de Vida , Ajustamento Social
11.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(2): 149-154, 2020 Apr 01.
Artigo em Chinês | MEDLINE | ID: mdl-32314887

RESUMO

OBJECTIVE: This research aims to collect speech samples from patients with cleft palate, establish a mandarin-based database of cleft palate speech after sample analysis and classification, and provide a reference for the diagnosis of hypernasal or cleft palate, clinical education, and standard training for professional speech therapists and related research. METHODS: A total of 768 speech samples were collected from patients and volunteers from the Speech Therapy Center, West China Hospital of Stomatology, between May 2016 and March 2018. These samples were edited and categoried before being saved into the cleft lip and palate biologic information database. RESULTS: A mandarin-based database of cleft palate speech was established from 768 subjects, including 456 children (male 227, female 229), 312 adults (male 178, female 134), 369 normal speech voices, 155 low-level hypernasal samples, 102 moderate-level hypernasal samples, 142 high-level hypernasal samples, and 64 512 words, 24 576 phonemes, and 7 680 numbers. CONCLUSIONS: This study first established a mandarin-based database of cleft palate speech, which has enormous value for the education of speech pathology of cleft palate in mandarin and further research.


Assuntos
Fenda Labial , Fissura Palatina , Adulto , Criança , China , Feminino , Humanos , Masculino , Fala
12.
J Orofac Orthop ; 81(3): 209-219, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32342120

RESUMO

PURPOSE: The aim of this study was to evaluate the hard and soft tissue effects and differences of the Alt-RAMEC protocol to the facemask and conventional facemask protocols in patients with unilateral cleft lip and palate. METHODS: This prospective study was carried out with 30 patients with unilateral cleft lip and palate with skeletal and dental class III malocclusions who were referred to a university department of orthodontics. The patients were evaluated with the cervical vertebral maturation method and divided into two groups, each consisting of 15 patients. The patients in group I (mean age 10.00 ± 0.73 years) were treated according to conventional facemask protocol, and the patients in group II (mean age 10.07 ± 2.43 years) were treated according to the Alt-RAMEC protocol before facemask application. Lateral cephalometric radiographs were evaluated by using the Dolphin Imaging Software version 11.7. The skeletal, dentoalveolar and soft tissue differences and treatment times were evaluated. RESULTS: Group II demonstrated a 5.73° increase in SNA, which was statistically significant, while this increase was 3.13° in group I (p < 0.001). Results for Co­A and A­PTV showed a significant increase for group II only (group I: 1.02 mm, 1.06 mm, group II: 3.02 mm, 2.21 mm; p < 0.05 and p < 0.01, respectively). In addition, group II presented significant increase for the values of ANB, N­A-Pg, SN/MP, Wits, U1-SN, U1-L1, U1-PTV, U1-FHP, U6-PTV, U6-FHP, overjet, Ss-PTV, UL-PTV and UL­S line (p < 0.001). The treatment mean times were 7.3 months in group I and 4.7 months in group II (p < 0.01). CONCLUSION: Applying the facemask after having followed the Alt-RAMEC protocol induced more skeletal, dentoalveolar and soft tissue changes in comparison to the conventional facemask protocol in patients with unilateral cleft lip and palate.


Assuntos
Fenda Labial , Fissura Palatina , Má Oclusão de Angle Classe III , Cefalometria , Criança , Aparelhos de Tração Extrabucal , Humanos , Maxila , Técnica de Expansão Palatina , Estudos Prospectivos
13.
Ned Tijdschr Tandheelkd ; 127(3): 147-151, 2020 Mar.
Artigo em Holandês | MEDLINE | ID: mdl-32343274

RESUMO

Inattention while taking dental impressions of the upper jaw of patients with a palatal defect can lead to dental impression material being left behind. Two patients with a cheilognathopalatoschisis and a full arch prosthesis in the upper jaw were referred with complaints characteristic of chronic sinusitis and recurrent epistaxis, lasting several years. A facial cone beam computer tomogram revealed dental impression material left behind in the palatal defect and the nasal cavity. In the case of both patients, the foreign bodies were removed under general anaesthesia. One of the patients twice brought up a residual fragment of dental impression material left in the palatal defect after surgery.


Assuntos
Fenda Labial , Materiais para Moldagem Odontológica , Técnica de Moldagem Odontológica , Modelos Dentários , Humanos , Maxila
14.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 37(4): 471-474, 2020 Apr 10.
Artigo em Chinês | MEDLINE | ID: mdl-32219840

RESUMO

OBJECTIVE: To explore the genetic basis for a fetus with cleft lip and palate. METHODS: Copy number variations (CNVs) in the fetus and his parents were detected with chromosomal microarray analysis (CMA). RESULTS: As revealed by the CMA assay, the fetus has carried a 228 kb deletion in Xp11.22 region and a 721 kb duplication in 9p21.1. Both CNVs were inherited from the parents. The CNV in Xp11.22 was predicted to be pathogenic by involving the PHF8 gene, whilst the CNV in 9p21.1 was predicted to be benign. CONCLUSION: Deletion of the Xp11.22 region probably underlies the cleft lip and palate in this fetus.


Assuntos
Fenda Labial , Fissura Palatina , Análise em Microsséries , Diagnóstico Pré-Natal , Deleção Cromossômica , Cromossomos Humanos X/genética , Fenda Labial/diagnóstico , Fenda Labial/genética , Fissura Palatina/diagnóstico , Fissura Palatina/genética , Variações do Número de Cópias de DNA , Feminino , Feto , Histona Desmetilases , Humanos , Análise em Microsséries/métodos , Gravidez , Fatores de Transcrição
15.
Stomatologiia (Mosk) ; 99(1): 77-81, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32125307

RESUMO

The aim of the work was a comprehensive assessment of the system of cytokines and peripheral blood osteocalcin with the establishment of features of their interconnections in children with congenital cleft lip and palate (CCLP) in comparison with the corresponding controls at different age periods. In the peripheral blood of 80 children (0-12 months, 1-3 years, 4-9 years, 10-15 years) with osteocalcin and IL17, IL4, congenital cleft lip and palate and age-appropriate control of healthy individuals (40 people) IL6, IL1ß, IFNγ by enzyme immunoassay. An analysis of the data obtained with CCLP revealed significant differences in the dynamics of the relationship between pro-inflammatory (IL1ß, IL6, IL17), regulatory (IFNγ), anti-inflammatory (IL4) cytokines and osteocalcin compared with controls. The patterns of changes and effects of IL17, IFNγ, IL4 and osteocalcin in healthy children and in children with congenital cleft lip and palate in postnatal ontogenesis were established. Cytokine dysregulation of immunosteogenesis in CCLP, leading to a significant deficit of osteocalcin in the first year of life due to an imbalance of the cytokine profile: discordant IL17, IFNγ and IL4 were detected. Thus, the data obtained are undoubtedly important in the future for developing new strategies for targeted therapy aimed at normalizing osteocalcin levels at different age periods in children with congenital cleft lip and palate.


Assuntos
Fenda Labial , Fissura Palatina , Criança , Citocinas , Humanos , Osteocalcina , Osteogênese
16.
PLoS One ; 15(3): e0230534, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32196525

RESUMO

Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.


Assuntos
Encéfalo/anormalidades , Fenda Labial/diagnóstico , Fissura Palatina/diagnóstico , Dermatoglifia , Análise de Variância , Fenda Labial/genética , Fissura Palatina/genética , Estudos de Coortes , Família , Feminino , Humanos , Masculino , Fenótipo , Fatores Sexuais
17.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 34(2): 200-205, 2020 Feb 15.
Artigo em Chinês | MEDLINE | ID: mdl-32030952

RESUMO

Objective: To discuss the clinical application and effectiveness of autologous costal cartilage transplantation in the repair of upper lip depression in the secondary repair of cleft lip. Methods: The clinical data of 10 patients of secondary repair of upper lip depression with cleft lip by autologous costal cartilage transplantation between January 2017 and January 2019 were retrospectively analysed. There were 7 males and 3 females with an average age of 24 years (range, 18-33 years). There were 8 cases of bilateral lip fissure and 2 cases of unilateral lip fissure. All of them underwent early lip repair at the age of 2-3 years old. The change of the profile of the soft tissue profile of the upper lip of the patient was quantitatively analyzed before operation and at immediate after operation, including the soft tissue facial angle (G-Sn-Pg'), the nasolabial angle (Cm-Sn-UL), the mentolabial angle (UL-LL-Pg'), the distance between the most salient point of the upper lip to the aesthetic plane (UL-E), the highest point of the frontal part, the projection distance of the most salient point of the upper lip on the plane of the orbital ear (G-UL), and the upper lip protrusion (ULP). Results: One case had incision infection and healed after dressing change, and in the other 9 patients, the incisions healed by first intention, and no acute infection and other complications occurred. The appearance of the lateral morphology of the upper lip at immediate after operation was significantly improved when compared with that before operation. The value of UL-LL-Pg', UL-E, G-UL, and ULP were significantly increased and G-Sn-Pg' was significantly decreased when compared with preoperative ones ( P<0.05). There was no significant difference in Cm-Sn-UL between pre- and post-operation ( t=0.821, P=0.433). All the 10 patients were followed up 6-24 months, with an average of 15 months. During the follow-up, the soft tissue morphology of the upper lip was good. No long-term complications such as cartilage absorption and cartilage displacement were found. Conclusion: Autologous costal cartilage transplantation is a safe and effective treatment for upper lip depression in the secondary repair of cleft lip.


Assuntos
Fenda Labial , Cartilagem Costal , Adolescente , Adulto , Pré-Escolar , Fenda Labial/cirurgia , Depressão , Feminino , Humanos , Masculino , Nariz , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
18.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 37(2): 139-141, 2020 Feb 10.
Artigo em Chinês | MEDLINE | ID: mdl-32034739

RESUMO

OBJECTIVE: To detect potential variant in a male fetus suspected for Ectrodactyly, Ectodermal dysplasia, Cleft lip/palate (EEC) syndrome. METHODS: Peripheral blood samples of the fetus and his parents were collected for the extraction of DNA. Whole-exome sequencing was carried out to detect potential variants. Suspected variants were verified by Sanger sequencing. RESULTS: The fetus was found to carry a heterozygous c.673C>T missense variant of the Tp63 gene, which was known to underlie split-hand/split-foot malformation. The same variant was not found in either parents. CONCLUSION: The heterozygous c.673C>T missense variant of the Tp63 gene probably underlies the EEC syndrome in the fetus. Above finding also expanded the phenotypic spectrum for this variant.


Assuntos
Fenda Labial , Fissura Palatina , Displasia Ectodérmica , Fatores de Transcrição/genética , Proteínas Supressoras de Tumor/genética , Fenda Labial/genética , Fissura Palatina/genética , Displasia Ectodérmica/genética , Humanos , Deformidades Congênitas dos Membros , Masculino , Sequenciamento Completo do Exoma
19.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 37(2): 195-199, 2020 Feb 10.
Artigo em Chinês | MEDLINE | ID: mdl-32034754

RESUMO

The molecular mechanism of cleft lip and palate has been a hot topic for research in recent years. With the development of genetic technology, more than 100 genes have been associated with cleft lip and palate, though the pathological mechanism of such genes has not been delineated.The information carried by each of these genes may affect the phenotype through signal pathway, and abnormal function of these signal pathways has been found in the formation of cleft lip and palate. A series of signal factors have known to involve in the regulation of gene expression, and may interact with each other to form complex signal regulatory networks which are involved in the guidance of cell activity and tissue formation. This article has summarized several signal pathways related to lip and palate, and the molecular mechanism underlying the development of lip and palate.


Assuntos
Fenda Labial , Fissura Palatina , Humanos , Fenótipo , Transdução de Sinais
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA