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1.
Artigo em Chinês | MEDLINE | ID: mdl-35959585

RESUMO

In this article we reported 13 cases of the substantial nasal mass in children. Among 13 these patients, 3 cases were septal hemangioma, 2 cases were maxillary hemangioma, 1 case was nasal infantile fibromatosis, 1 case was osteoblastoma of the nasal cavity and sinuses, 2 cases were lymphoma of nasopharynx, 1 case was maxillary lymphoma, 1 case was rhabdomyosarcoma of nasopharynx, 1 case was maxillary squamous-cell carcinoma, 1 case was squamous-cell carcinoma of nasopharynx.All 13 cases were treated with surgery, 1 case with nasal infantile fibromatosis, 2 cases with lymphoma of nasopharynx, 1 case with rhabdomyosarcoma of nasopharynx, 1 case with nasopharyngeal carcinoma and 1 case with maxillary carcinoma were taken postoperative radiotherapy and chemotherapy. The most common substantial nasal mass in children was hemangioma. This study included 2 cases with nasal invasive benign tumors, 1 case with nasal infantile fibromatosis and 1 case with osteoblastoma of the nasal cavity and sinuses. The functional nasal endoscopic surgery of mass resection was the main method for the treatment of mass in this area and had achieved satisfied effect. Lymphoma and rhabdomyosarcoma were the most common nasal malignant tumor in children. Nasopharyngeal carcinoma and maxillary carcinoma were not uncommon.


Assuntos
Neoplasias Ósseas , Carcinoma de Células Escamosas , Fibroma , Hemangioma , Linfoma , Neoplasias Nasofaríngeas , Neoplasias Nasais , Osteoblastoma , Rabdomiossarcoma , Carcinoma de Células Escamosas/patologia , Criança , Fibroma/patologia , Humanos , Cavidade Nasal/patologia , Carcinoma Nasofaríngeo , Neoplasias Nasofaríngeas/patologia , Neoplasias Nasais/patologia , Neoplasias Nasais/terapia , Osteoblastoma/patologia
2.
J Craniofac Surg ; 33(5): e465-e467, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36041129

RESUMO

ABSTRACT: Chondromyxoid fibroma is a rare benign tumor mostly found in the metaphysis of long bones. In rare cases, it develops in unusual locations. We report a case of chondromyxoid fibroma from the nasal septum. Endoscopic surgery was performed with the patient under general anesthesia. A plasma knife was used to ablate the tumor. No recurrence was noted at the 4-year follow-up. The advantages of endoscopic surgery include direct observation, improved visibility and magnification, reduced intraoperative trauma, and fewer postoperative complications. The advantages of the plasma knife include its ability to separate and ablate the tumor simultaneously while effectively reducing bleeding and maintaining the visibility of the surgical field.


Assuntos
Neoplasias Ósseas , Fibroma , Neoplasias Ósseas/cirurgia , Fibroma/diagnóstico por imagem , Fibroma/patologia , Fibroma/cirurgia , Humanos , Septo Nasal/diagnóstico por imagem , Septo Nasal/patologia , Septo Nasal/cirurgia
3.
Adv Anat Pathol ; 29(5): 309-323, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35838633

RESUMO

Spindle cell proliferations of the breast are a heterogeneous group of lesions ranging from benign or reactive lesions to aggressive malignant neoplasms. Diagnosis on core biopsy can be particularly challenging as lesions displaying different lineages associated with variable outcomes share overlapping morphologies (scar vs. fibromatosis-like metaplastic carcinoma) whereas individual entities can exhibit a large variety of appearances (myofibroblastoma). In this review, lesions are grouped into lineage, when possible, including those showing fibroblastic/myofibroblastic differentiation, ranging from entities that require no additional management, such as scar and nodular fasciitis, to those with unpredictable clinical outcomes such as fibromatosis and solitary fibrous tumor or locally aggressive behavior such as dermatofibrosarcoma protuberans. The review of low-grade vascular lesions includes atypical vascular lesion and low-grade angiosarcoma. Also discussed are various adipocytic lesions ranging from lipoma to liposarcoma, and rare smooth muscle and neural entities more commonly encountered in locations outside the breast, such as leiomyoma, neurofibroma, schwannoma, or granular cell tumor. Optimal histological evaluation of these entities merges clinical and radiologic data with morphology and ancillary testing. We present our approach to immunohistochemical and other ancillary testing and highlight issues in pathology correlation with imaging. Recent updates in the management of breast spindle cell lesions are addressed. In a well-sampled lesion with radiographic concordance, the core biopsy diagnosis reliably guides management and we advocate the inclusion of management recommendations in the pathology report. Precise characterization using up to date guidelines is important to identify a subset of patients who may safely avoid unnecessary surgical procedures. A multidisciplinary approach with close collaboration with our clinical colleagues is emphasized.


Assuntos
Neoplasias da Mama , Fibroma , Biópsia por Agulha , Mama/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/patologia , Cicatriz/patologia , Diagnóstico Diferencial , Feminino , Fibroma/diagnóstico , Fibroma/patologia , Humanos
4.
Pan Afr Med J ; 41: 206, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35685109

RESUMO

Cardiac papillary fibroelastoma is a rare, benign tumour, arising from the valvular endocardium, which could lead to life-threatening complications as myocardial ischemia. We report a case of a 54-year-old male patient who presented in the emergency room with an acute coronary syndrome with transient ST segment elevation. After ruling out coronary artery disease by coronarography, we established the diagnosis of papillary fibroelastoma by performing echocardiogram completed by computed tomography angiography. The reversible acute coronary syndrome has been caused by the prolapse of pedunculated coronary cusp tumour into the main left coronary ostium. The patient was scheduled for emergent surgery. The surgical management included a complete resection of the tumour sparing the aortic valve. The patient recovered well. A papillary fibroelastoma of the aortic valve can be revealed by an acute coronary syndrome with transient ST segment elevation. More investigations must be done to eliminate such diagnosis in the case of a normal coronarography.


Assuntos
Síndrome Coronariana Aguda , Fibroelastoma Papilar Cardíaco , Doença da Artéria Coronariana , Fibroma , Neoplasias Cardíacas , Síndrome Coronariana Aguda/complicações , Síndrome Coronariana Aguda/etiologia , Valva Aórtica/patologia , Valva Aórtica/cirurgia , Doença da Artéria Coronariana/complicações , Fibroma/diagnóstico , Fibroma/patologia , Fibroma/cirurgia , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade
5.
BMC Musculoskelet Disord ; 23(1): 464, 2022 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-35581638

RESUMO

BACKGROUND: Neuromuscular choristomas (NMCs), are extremely rare developmental lesions that, have been previously established associated with recurrent fibromatosis after surgery, leading to several operations or even amputation. However, reports on the ultrasound imaging features and clinical conditions of NMCs are rare. The purpose of this study is to describe the ultrasound features and clinical analysis of NMCs to provide suggestions to identify the optimal management strategy. METHODS: From September 2020 to September 2021, 7 patients with a confirmed diagnosis of NMC who underwent ultrasound examination in our department were enrolled in our study. Physical examinations were performed to detect motor deficits, sensory deficits, neuropathic pain, limb undergrowth, muscular atrophy, cavus foot and bone dysplasia. Ultrasound imaging was performed and investigated both in affected nerves and neuromuscular choristomas associated desmoid-type fibromatosis (NMC-DTF). All patients had a definite history and regular follow-up. The clinical course, physical examinations, ultrasound features and pathologic results of NMC patients were analyzed. RESULTS: Seven patients with an average age of 7.0 ± 7.2 years (range: 2-22 years) were enrolled in our study. The affected nerves included the sciatic nerve (6 cases) and the brachial plexus (1 case). Six patients (85.7%) presented with limb undergrowth, 6 (85.7%) with muscular atrophy, and 5 (71.4%) with cavus foot deformity. Based on ultrasound findings, all the visibly affected nerve segments presented with hypoechoic and fusiform enlargement with intraneural skeletal muscle elements. Five patients (71.4%) had NMC-DTFs at the site of the affected nerve. All NMC-DTFs were shown as hypoechoic solid lesions adjacent to the nerve and were well circumscribed. In the subset of the surgery group, all 5 patients presented with progression to NMC-DTFs at the site of the NMCs. No fibromatosis was detected in the other two nonsurgical patients. CONCLUSIONS: Understanding the typical ultrasound features and clinically associated conditions would support the early diagnosis of this rare disease. When a potential diagnosis is determined, an invasive procedure such as biopsy or resection might not be a good choice given the frequent occurrence of complications such as aggressive recurrence.


Assuntos
Coristoma , Fibroma , Fibromatose Agressiva , Hamartoma , Adolescente , Criança , Coristoma/complicações , Coristoma/patologia , Fibroma/patologia , Hamartoma/patologia , Humanos , Músculo Esquelético/patologia , Atrofia Muscular/patologia , Doenças Raras/complicações
6.
Diagn Cytopathol ; 50(8): 375-385, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35429232

RESUMO

OBJECTIVE: This study has been designed in an effort to identify the clinico-radiological and cytological features that could effectively help in differentiating cellular fibroadenoma (CFA) and phyllodes tumors (PT), which have several overlapping characteristics. METHOD: Histologically proven cases of CFA and PT were reviewed. Cytological features were assessed and categorized. Clinical and radiological details were also evaluated and he the two groups were compared statistically. RESULTS: A total of 43 FA and 52 PT were specimens were reviewed. Mean age and tumor size for CFA and PT were 26.05 and 36.94 years, and 3.7 and 6.4 cm, respectively. Univariate analysis and regression models revealed that age >30 years, BIRADS grade of 4 or more, marked cellularity of stromal fragments, more than 30% spindle cells in background cell population and presence of traversing blood vessels in stromal fragments increased the odds of a tumor being phyllodes. The binary logistic regression model was able to predict PT accurately in 87.2% cases (p <  .001). CONCLUSION: PT and CFA could be differentiated if cytological findings are cautiously correlated clinically and radiologically. Age, BIRADS category along with assessment of stromal fragments and background population can effectively distinguish between CFA and PT.


Assuntos
Neoplasias da Mama , Fibroadenoma , Fibroma , Tumor Filoide , Adulto , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Fibroadenoma/diagnóstico por imagem , Fibroadenoma/patologia , Fibroma/patologia , Humanos , Tumor Filoide/patologia , Células Estromais/patologia
7.
Stomatologiia (Mosk) ; 101(2): 69-73, 2022.
Artigo em Russo | MEDLINE | ID: mdl-35362706

RESUMO

Hyaline juvenile fibromatosis is a rare genetic disease, which is associated with ANTXR2 gene defect. Almost all organs and systems of the body are affected in this pathology. There are clinical symptoms: joint contracture, hyperpigmentation, skin damage like nodules, which can have different sizes, locations and forms, throughout the body, fibromatosis of the gums, internal organs damages (splenomegaly, hepatomegaly, anomalies of the kidneys and other organs), osteoporosis, increased susceptibility to infectious diseases, mental underdevelopment. In this article we describe clinical case of 6-old patient witht hyaline juvenile fibromatosis. The diagnosis was made on the basis of the clinical picture, additional research methods and the results of molecular genetic testing. The patient underwent a number of surgical interventions, histological examination of the surgical material and symptomatic therapy.


Assuntos
Fibroma , Hialina , Fibroma/patologia , Humanos , Receptores de Peptídeos
8.
Br J Radiol ; 95(1136): 20210790, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35451310

RESUMO

OBJECTIVE: The aim of this study was to investigate the CT imaging characteristics of ovarian fibrothecoma which may aid in the differentiation from early stage epithelial tumours. METHODS: Comparison of 36 patients (41 lesions) with pathologically proven ovarian fibrothecoma tumours and 36 (52 lesions) serous papillary carcinomas (SPCs) lesions. We noted their laterality, size, density, calcifications, Hounsfield units (HUs) and introduced a novel HU comparison technique with the psoas muscle or the uterus. Patients' clinical findings such as ascites, pleural effusion, carbohydrate antigen-125 levels, and lymphadenopathy findings were also included. RESULTS: Average age was 67.8 and 66 across the fibrothecoma and SPC cohort respectively. Fibrothecoma tumours had diameters ranging from 24 to 207 mm (Median: 94 mm). 80.6% of the fibrothecoma cohort had ascites which was comparable to the 72.2% in the SPC cohort. 70.7% of fibrothecoma tumour favour a purely to predominantly solid structural configuration (p < 0.001). The average HU value for the fibrothecoma solid component was 44 ± 11.7 contrasting the SPC HU value of 66.8 ± 15. The psoas:tumour mass ratio demonstrated a median of 0.7, whereas SPCs shows a median of 1.1 (p < 0.001). CONCLUSION: Suspicion of ovarian fibrothecoma should be considered through interrogation of their structural density configuration, low psoas to mass HU ratio and a presence of ascites. ADVANCES IN KNOWLEDGE: CT imaging can be a useful tool in diagnosing fibrothecoma tumours and subsequently reducing oncogynaecological tertiary centre referrals, financial burden and patient operative morbidity and mortality.


Assuntos
Fibroma , Neoplasias Epiteliais e Glandulares , Neoplasias Ovarianas , Tumor da Célula Tecal , Ascite , Antígeno Ca-125 , Feminino , Fibroma/diagnóstico , Fibroma/patologia , Tumor de Células da Granulosa , Humanos , Neoplasias Ovarianas/patologia , Estudos Retrospectivos , Tumor da Célula Tecal/diagnóstico por imagem , Tumor da Célula Tecal/patologia , Tomografia Computadorizada por Raios X
9.
J Card Surg ; 37(6): 1716-1717, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35353382

RESUMO

Residual tumor mass after large cardiac fibroma resection carries long-term risk, but cryoablation is useful during surgery to remove such tissue. Here, we present a case of a large cardiac fibroma of the posterior wall of the left ventricle, discovered during long-term, episodic ventricular tachycardia. Resection with cryoablation completely removed the tumor, eliminating postoperative, distant ventricular arrhythmias.


Assuntos
Criocirurgia , Fibroma , Neoplasias Cardíacas , Taquicardia Ventricular , Fibroma/diagnóstico por imagem , Fibroma/patologia , Fibroma/cirurgia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Ventrículos do Coração/patologia , Ventrículos do Coração/cirurgia , Humanos , Taquicardia Ventricular/etiologia , Taquicardia Ventricular/cirurgia
10.
Ann Diagn Pathol ; 58: 151914, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35278805

RESUMO

By a set of curious chances, Dr. F.M.Enzinger went from being captured as a prisoner of war by the American Army in Normandy in 1944 to become Head of the Soft Tissue Department of the Armed Forces Institute of Pathology (AFIP) in Washington DC and a friend of one of the directors, Major General Joe M. Blumberg. The author relates how he worked under Enzinger from 1967 to 1970. Enzinger would review all the slides of referred consultation cases on alternate days and record his diagnoses on filing cards kept in his personal file which supplemented the computerised AFIP central file. Periodic reviews of the files allowed him to retrieve large numbers of recognised tumors and to study potential cases of previously undescribed entities. During his 31 years at the AFIP, Enzinger lectured widely, wrote numerous papers on recognised entities, co-authored with Dr. Sharon W. Weiss their famous text book and discovered the following 26 previously undefined soft tissue tumors: clear cell sarcoma, intramuscular myxoma, epithelioid sarcoma, extra-skeletal myxoid chondrosarcoma, fetal rhabdomyoma, extra-skeletal Ewing's sarcoma, spindle cell lipoma, fibroma of tendon sheath, angiomatoid (malignant) fibrous histiocytoma, cranial fasciitis of childhood, intravascular fasciitis, pleomorphic lipoma, neuromuscular hamartoma, epithelioid hemangioendothelioma, spindle cell hemangioma, fibro-osseous pseudotumor of the digits, plexiform fibrohistiocytic tumor, giant cell fibroblastoma as a juvenile form of dermatofibrosarcoma protuberans, ossifying fibromyxoid tumor, myolipoma of soft tissues, inflammatory fibrosarcoma, juxta-articular myxoma, atypical decubital fibroplasia, chondroid lipoma, sclerosing epithelioid fibrosarcoma, and lipofibromatosis. His last discovery, co-authored by some of his AFIP followers, was published in 2000. He died in 2006. The AFIP itself was "disestablished" only five years later, which will make it very difficult for any future pathologist to exceed Enzinger's astonishing record of 26 "new" tumor discoveries.


Assuntos
Fasciite , Fibroma , Fibrossarcoma , Histiocitoma Fibroso Maligno , Lipoma , Mixoma , Sarcoma , Neoplasias de Tecidos Moles , Adulto , Criança , Fibroma/patologia , Humanos , Masculino , Sarcoma/patologia , Neoplasias de Tecidos Moles/patologia
12.
J Am Podiatr Med Assoc ; 112(1)2022 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-35324461

RESUMO

Ledderhose disease (plantar fibromas) is histologically related to Dupuytren disease, which has been successfully treated for years with radiotherapy. Many conservative treatments have been advanced for plantar fibromas, including accommodative orthotic devices, which help but do not cure the disease. Surgery is considered the mainstay of treatment for this malady, but the failure rate has been as high as 100%, depending on the type of fasciectomy. Radiotherapy is a new, exciting modality that has shown promising results for treating plantar fibromas.


Assuntos
Fibroma , Fibromatose Plantar , Doenças do Pé , Fasciotomia , Fibroma/patologia , Fibroma/radioterapia , Doenças do Pé/patologia , Humanos
13.
Acta Neurochir (Wien) ; 164(7): 1961-1965, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35312869

RESUMO

BACKGROUND: The surgical resection of the tumor spreading into the cavernous sinus (CS) is complicated and challenging. METHOD: We report a left recurrent CS chondromyxoid fibroma occupying the clival-petrous apex-parasellar-suprasellar area, which was totally removed by the micro-endo combination technique via the middle cranial fossa extradural approach. CONCLUSION: This case demonstrates the value of the micro-endoscopic combination technique for complicated skull base surgery.


Assuntos
Seio Cavernoso , Fibroma , Neoplasias da Base do Crânio , Seio Cavernoso/cirurgia , Fossa Craniana Média , Fossa Craniana Posterior/cirurgia , Endoscopia , Fibroma/patologia , Humanos , Neoplasias da Base do Crânio/diagnóstico por imagem , Neoplasias da Base do Crânio/patologia , Neoplasias da Base do Crânio/cirurgia
14.
Can Vet J ; 63(2): 139-142, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35110769

RESUMO

A 12-year-old, spayed female, Maltese dog with a round and firm mass on the dorsal part of the left rear paw and a cervical mass was brought to the clinic. The paw mass was contiguous to the adjacent tendon; it was composed of neoplastic mesenchymal cells and had scattered foci of calcification with chondroid differentiation microscopically. The neoplastic cells were positive for vimentin and S100, but negative for desmin and smooth muscle actin. Microscopic features and immunohistochemistry results were consistent with calcifying aponeurotic fibroma (CAF). The cervical mass was composed of polygonal cells forming acini with marked anisocytosis and anisokaryosis and diagnosed as thyroid follicular carcinoma. No recurrence or metastasis occurred during follow-up. To the best of our knowledge, this is the first case of canine CAF with features identical to its human counterparts. Key clinical message: This report describes the rare case of calcifying aponeurotic fibroma on the paw in a dog. This is apparently the first case in the veterinary literature with identical clinical and pathological features to the human counterpart.


Fibrome aponévrotique calcifiant sur la patte chez un chien. Une chienne maltaise stérilisée âgée de 12 ans avec une masse ronde et ferme sur la partie dorsale de la patte arrière gauche et une masse cervicale a été amenée à la clinique. La masse de la patte était contiguë au tendon adjacent; il était composé de cellules mésenchymateuses néoplasiques et présentait des foyers de calcification dispersés avec une différenciation chondroïde au microscope. Les cellules néoplasiques étaient positives pour la vimentine et le S100, mais négatives pour la desmine et l'actine des muscles lisses. Les caractéristiques microscopiques et les résultats d'immunohistochimie étaient compatibles avec un fibrome aponévrotique calcifiant (CAF). La masse cervicale était composée de cellules polygonales formant des acini avec une anisocytose et une anisocaryose marquées et diagnostiquée comme un carcinome folliculaire de la thyroïde. Aucune récidive ou métastase n'est survenue au cours du suivi. À notre connaissance, il s'agit du premier cas de CAF canin avec des caractéristiques identiques à ses homologues humains.Message clinique clé :Ce rapport décrit le cas rare de fibrome aponévrotique calcifiant sur la patte chez un chien. C'est apparemment le premier cas dans la littérature vétérinaire avec des caractéristiques cliniques et pathologiques identiques à son homologue humain.(Traduit par Dr Serge Messier).


Assuntos
Calcinose , Doenças do Cão , Fibroma Ossificante , Fibroma , Neoplasias de Tecidos Moles , Animais , Calcinose/patologia , Calcinose/cirurgia , Calcinose/veterinária , Doenças do Cão/cirurgia , Cães , Feminino , Fibroma/patologia , Fibroma/cirurgia , Fibroma/veterinária , Fibroma Ossificante/veterinária , Neoplasias de Tecidos Moles/veterinária
15.
Ann Pathol ; 42(3): 242-248, 2022 Apr.
Artigo em Francês | MEDLINE | ID: mdl-35181149

RESUMO

Translocations involving FN1 gene have been described in several tumours, which share the presence of a cartilaginous matrix with or without calcifications and a good prognosis. They encompass: soft tissue chondroma, synovial chondromatosis, calcifying aponeurotic fibroma, phosphaturic mesenchymal tumour and a new spectrum of tumours: "the calcified chondroid mesenchymal neoplasms". We review all the clinical, histopathological and molecular data of these tumours and discuss the differential diagnoses.


Assuntos
Condroma , Fibroma Ossificante , Fibroma , Mesenquimoma , Neoplasias de Tecidos Moles , Condroma/patologia , Fibroma/patologia , Fibronectinas/genética , Humanos , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/patologia
16.
Medicina (Kaunas) ; 58(2)2022 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-35208506

RESUMO

Cardiac papillary fibroelastoma is a benign and rare primary tumor of the heart that is most frequently located in the aortic or the mitral valves. Papillary fibroelastoma arising from the left atrium is exceedingly rare, comprising less than 7% of all cardiac papillary fibroelastomas. Tumors in this location could be a source of cardioembolic stroke, often in the anterior circulation of the cerebrum. A 66-year-old female presenting with right hemiparesis, central facial palsy, homonymous hemianopia, and dysarthria received intravenous thrombolysis for stroke without apparent improvement. Magnetic resonance imaging of the brain revealed ischemic infarction in the territories of the left middle and posterior cerebral arteries. A tumor with a maximal diameter of 2.3 cm was disclosed during workup for possible cardioembolic stroke with transthoracic echocardiography and computed tomography of the heart. The clinical course was complicated by stroke-in-evolution and hemorrhagic transformation. The patient underwent left atrial tumor excision and left atrium appendage closure. In-patient stroke rehabilitation programs were also initiated after the conditions stabilized. No clinically significant complications developed after the operation. Neurological functions improved and the patient was able to perform most basic daily living activities with some assistance. An exhaustive search for the cause of cardioembolic stroke is paramount, as management strategies may differ from patients with thrombotic stroke.


Assuntos
Apêndice Atrial , Fibroma , Neoplasias Cardíacas , Acidente Vascular Cerebral , Idoso , Ecocardiografia Transesofagiana , Feminino , Fibroma/complicações , Fibroma/patologia , Fibroma/cirurgia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Humanos , Acidente Vascular Cerebral/complicações
17.
J Cutan Pathol ; 49(7): 638-644, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35191077

RESUMO

Low-grade fibromyxoid sarcoma (LGFMS) is a histopathologically deceptive soft tissue neoplasm with bland cytology, which is typically encountered in deep soft tissue of adults. We report two cases of superficial LGFMS in young patients (16 and 21 years old, respectively), which were difficult to diagnose on histopathologic and clinical findings alone. LGFMS commonly mimics benign neoplasms such as cellular neurothekeoma, fibromatosis, neurofibroma, and perineurioma. Malignancies included in the differential diagnosis are soft tissue neoplasms such as dermatofibrosarcoma protuberans and myxofibrosarcoma. A high degree of reported variation in pattern and cellularity among LGFMS further complicates the diagnosis. Careful examination and appropriate immunohistochemistry panels including MUC4 are essential for narrowing the differential diagnosis. Molecular studies for possible FUS translocation can confirm the diagnosis of LGFMS. Sufficient sampling and workup of these lesions are critical, especially in younger patients. Young age and superficial presentation can easily sway dermatopathologists/dermatologists toward an incorrect diagnosis of benignancy.


Assuntos
Fibroma , Fibrossarcoma , Neoplasias de Bainha Neural , Neoplasias de Tecidos Moles , Adolescente , Adulto , Fibroma/diagnóstico , Fibroma/patologia , Fibrossarcoma/diagnóstico , Fibrossarcoma/patologia , Humanos , Imuno-Histoquímica , Neoplasias de Tecidos Moles/patologia , Adulto Jovem
18.
BMC Pediatr ; 22(1): 59, 2022 01 22.
Artigo em Inglês | MEDLINE | ID: mdl-35065637

RESUMO

BACKGROUND: Lipofibromatosis is a rare, benign, soft tissue tumor that usually presents in children. Low incidence and lack of specificity in clinical presentation make its diagnosis difficult. CASE PRESENTATION: This is a case report of a patient with a giant lipofibromatosis on the back that resembles an infantile hemangioma, which posed great difficulty in diagnosis due to atypical clinical manifestations. After the postoperative pathological and immunohistochemical examination and fluorescence in situ hybridization, the patient was finally diagnosed with lipofibromatosis. CONCLUSIONS: The incidence of fibromatosis was low. This case presents an atypical clinical manifestation since the tumor growth was on the back, and this can easily cause misdiagnosis. This case suggests that the diagnosis of lipofibromatosis depends on the pathology and fluorescence in situ hybridization.


Assuntos
Fibroma , Neoplasias de Tecidos Moles , Criança , Fibroma/diagnóstico , Fibroma/patologia , Fibroma/cirurgia , Humanos , Hibridização in Situ Fluorescente , Lactente , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia
19.
Genes Chromosomes Cancer ; 61(4): 194-199, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-34874592

RESUMO

Cutaneous fibromyxoid neoplasms (CFMN) comprise a vast category of benign and malignant tumors that include, but are not limited to, low-grade fibromyxoid sarcoma, myxofibrosarcoma, myxoid dermatofibrosarcoma protuberans, myxoid solitary fibrous tumor, and myxoid neurofibroma with differing implications for treatment and prognosis. Herein, a case of CFMN arising as a painless, slow-growing, flesh-colored forearm mass in a 53-year-old female is presented. The neoplasm comprised of copious myxoid material with banal spindle cells, exhibiting mild hyperchromasia, dissecting the dermal collagen table. Focal perivascular accentuation of spindle cells was identified in the absence of vasoformative features. Immunohistochemically, lesional cells were strongly and diffusely positive for CD34 and multifocally for Factor XIIIa and epithelial membrane antigen while negative for CD31, ERG, FLI-1, D2-40, smooth muscle actin, Desmin, S100, HMB-45, STAT6, MUC4, and keratins. RNA- and DNA-sequencing identified a YAP1::TFE3 fusion transcript that were subsequently corroborated by fluorescence in situ hybridization and immunohistochemistry for TFE3 (Xp11.23) locus rearrangement and strong, diffuse TFE3 immunoreactivity, respectively. To date, the YAP1::TFE3 fusion has only been identified in a subset of epithelioid hemangioendotheliomas and clear cell stromal tumors of the lung. This is the first report of a CFMN featuring a YAP1::TFE3 fusion (YAP1 Exon 1 and TFE3 Exon 4). The morphologic findings are unlike those previously described for epithelioid hemangioendothelioma and suggest that this neoplasm may represent a yet unclassified or novel CFMN entity. Although the patient is 1-year status postsurgical excision with no evidence of clinical recurrence, the clinical behavior of this novel entity remains to be fully characterized.


Assuntos
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética , Fibroma/genética , Proteínas de Fusão Oncogênica/genética , Neoplasias Cutâneas/genética , /genética , Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo , DNA de Neoplasias , Feminino , Fibroma/metabolismo , Fibroma/patologia , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Pessoa de Meia-Idade , Proteínas de Fusão Oncogênica/metabolismo , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia , /metabolismo
20.
Head Neck Pathol ; 16(2): 587-595, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34341903

RESUMO

Glandular tumors of jaw bones present, most often, histopathologic features of salivary gland and, rarely, of cutaneous glandular neoplasms. They are thought to originate from odontogenic epithelium. An unusual maxillary tumor presenting as a radiolucency in the periapical area of the right permanent lateral incisor of a 74-year-old male is presented causing root resorption. Preparations revealed occasionally branching tubular cords and ductal structures characterized, mostly, by a bilayer composed of luminal cuboidal to low columnar cytokeratin (CK) 7, Ber-EP4 and occasionally CK8/18 positive cells, and abluminal, CK5/6 positive, basal/basaloid cells revealing nuclear reactivity for p63/p40. Smooth muscle actin and calponin were negative, save for a single focus of calponin positive cells, confirming absence of myoepithelial support or epithelial mesenchymal transition. CK19 exhibited staining of both layers, the luminal being more intense. Eosinophilic secretory material and, occasionally, a luminal pellicle were decorated with CK8/18 and polyclonal carcinoembryonic antigen (CEA). CD1a identified only rare Langerhans' cells and Ki67 decorated 1-2% of abluminal cell nuclei. Small solid nests of epithelial cells were also present. Infrequently, an apparent transition of a nest into a tubular structure was appreciated. The partially inflamed stroma featured multiple hyalinized acellular deposits consistent with amyloid, as confirmed by bright orange Congo red reactivity with apple-green birefringence, which reacted with odontogenic ameloblast-associated (ODAM) protein antibody but not with antibodies for amelotin and secretory calcium-binding phosphoprotein proline-glutamine rich 1. Based on the above, the diagnosis of tubuloductal/syringoid variant of central odontogenic fibroma with ODAM amyloid is favored.


Assuntos
Amiloidose , Fibroma , Neoplasias Maxilares , Tumores Odontogênicos , Idoso , Ameloblastos/metabolismo , Ameloblastos/patologia , Amiloide/metabolismo , Amiloidose/patologia , Fibroma/patologia , Humanos , Masculino , Neoplasias Maxilares/patologia , Tumores Odontogênicos/patologia
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