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1.
Dis Colon Rectum ; 65(1): 108-116, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34538832

RESUMO

BACKGROUND: Fecal management systems have become ubiquitous in hospitalized patients with fecal incontinence or severe diarrhea, especially in the setting of perianal wounds. Although fecal management system use has been shown to be safe and effective in initial series, case reports of rectal ulceration and severe bleeding have been reported, with a relative paucity of clinical safety data in the literature. OBJECTIVE: The purpose of this study was to determine the rate of rectal complications attributable to fecal management systems, as well as to characterize possible risk factors and appropriate management strategies for such complications. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a large academic medical center. PATIENTS: All medical and surgical patients who underwent fecal management system placement from December 2014 to March 2017 were included. MAIN OUTCOME MEASURES: We measured any rectal complication associated with fecal management system use, defined as any rectal injury identified after fecal management system use confirmed by lower endoscopy. RESULTS: A total of 629 patients were captured, with a median duration of fecal management system use of 4 days. Overall, 8 patients (1.3%) experienced a rectal injury associated with fecal management system use. All of the patients who experienced a rectal complication had severe underlying comorbidities, including 2 patients on dialysis, 1 patient with cirrhosis, and 3 patients with a recent history of emergent cardiac surgery. In 3 patients the bleeding resolved spontaneously, whereas the remaining 5 patients required intervention: transanal suture ligation (n = 2), endoscopic clip placement (n = 1), rectal packing (n = 1), and proctectomy in 1 patient with a history of pelvic radiotherapy. LIMITATIONS: The study was limited by its retrospective design and single institution. CONCLUSIONS: This is the largest study to date evaluating rectal complications from fecal management system use. Although rectal injury rates are low, they can lead to serious morbidity. Advanced age, severe comorbidities, pelvic radiotherapy, and anticoagulation status or coagulopathy are important factors to consider before fecal management system placement. See Video Abstract at http://links.lww.com/DCR/B698. INCIDENCIA Y CARACTERIZACIN DE LAS COMPLICACIONES RECTALES DE LOS SISTEMAS DE MANEJO FECAL: ANTECEDENTES:Los sistemas de manejo fecal se han vuelto omnipresentes en pacientes hospitalizados con incontinencia fecal o diarrea severa, especialmente en el contexto de heridas perianales. Aunque se ha demostrado que el uso del sistema de tratamiento fecal es seguro y eficaz en la serie inicial, se han notificado casos de ulceración rectal y hemorragia grave, con una relativa escasez de datos de seguridad clínica en la literatura.OBJETIVO:Determinar la tasa de complicaciones rectales atribuibles a los sistemas de manejo fecal. Caracterizar los posibles factores de riesgo y las estrategias de manejo adecuadas para tales complicaciones.DISEÑO:Estudio de cohorte retrospectivo.ENTORNO CLINICO:Centro médico académico de mayor volumen.PACIENTES:Todos los pacientes médicos y quirúrgicos que se sometieron a la colocación del sistema de manejo fecal desde diciembre de 2014 hasta marzo de 2017.PRINCIPALES MEDIDAS DE VALORACION:Cualquier complicación rectal asociada con el uso del sistema de manejo fecal, definida como cualquier lesión rectal identificada después del uso del sistema de manejo fecal confirmada por endoscopia baja.RESULTADOS:Se identificaron un total de 629 pacientes, con una duración media del uso del sistema de manejo fecal de 4,0 días. En general, 8 (1,3%) pacientes desarrollaron una lesión rectal asociada con el uso del sistema de manejo fecal. Todos los pacientes que mostraron una complicación rectal tenían comorbilidades subyacentes graves, incluidos dos pacientes en diálisis, un paciente con cirrosis y tres pacientes con antecedentes recientes de cirugía cardíaca emergente. En tres pacientes el sangrado se resolvió espontáneamente, mientras que los cinco pacientes restantes requirieron intervención: ligadura de sutura transanal (2), colocación de clip endoscópico (1), taponamiento rectal (1) y proctectomía en un paciente con antecedentes de radioterapia pélvica.LIMITACIONES:Diseño retrospectivo, institución única.CONCLUSIONES:Este es el estudio más grande hasta la fecha que evalúa las complicaciones rectales del uso del sistema de manejo fecal. Si bien las tasas de lesión rectal son bajas, pueden provocar una morbilidad grave. La edad avanzada, las comorbilidades graves, la radioterapia pélvica y el estado de anticoagulación o coagulopatía son factores importantes a considerar antes de la colocación del sistema de manejo fecal. Consulte Video Resumen en http://links.lww.com/DCR/B698.


Assuntos
Incontinência Fecal/terapia , Fissura Anal/diagnóstico , Hemorragia/diagnóstico , Doenças Retais/patologia , Reto/lesões , Idoso , Comorbidade/tendências , Gerenciamento Clínico , Endoscopia do Sistema Digestório/métodos , Incontinência Fecal/epidemiologia , Feminino , Fissura Anal/epidemiologia , Fissura Anal/cirurgia , Hemorragia/epidemiologia , Hemorragia/cirurgia , Humanos , Incidência , Ligadura/métodos , Masculino , Pessoa de Meia-Idade , Pelve/patologia , Pelve/efeitos da radiação , Protectomia/métodos , Doenças Retais/cirurgia , Reto/diagnóstico por imagem , Reto/patologia , Estudos Retrospectivos , Fatores de Risco , Segurança , Suturas , Cirurgia Endoscópica Transanal/métodos
2.
Niger J Clin Pract ; 23(4): 539-544, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32246662

RESUMO

BACKGROUND: Anal fissure which is defined as a longitudinal tear in anoderm below the dentate line is one of the most common benign diseases of anorectal area. Severe pain during the defecation and emotional stress that it causes may reduce people's quality of life. AIMS: In this randomized clinical trial, we aimed to compare the efficiency of the topical ointment with medical treatment and surgical lateral internal sphincterotomy. METHOD: This is a randomized clinical trial of 550 patients who were treated for chronic anal fissure. Patients were randomly divided into 4 groups according to the treatment type they received. RESULTS: In a vast majority of the patients, the primary complaint was pain (92.3%) and bleeding during defecation (62%). Both pain relief and healing of the fissure, which are the components of response to treatment, had not been observed in 56 (37.3%) patients of topical nitroglycerin ointment group until the second month. Among the recalcitrant patients in both topical nitroglycerin (56) and topical diltiazem ointment (47) groups, 27 (48.2%), and 36 (76.5%) patients underwent surgery, respectively. The best response to treatment was also obtained in lateral internal sphincterotomy group. CONCLUSION: LIS is still the gold standard for the treatment of chronic anal fissure when the physicians would like to avoid recurrence and obtain the best pain relief.


Assuntos
Fissura Anal , Esfincterotomia , Doença Crônica , Diltiazem/uso terapêutico , Fissura Anal/tratamento farmacológico , Fissura Anal/epidemiologia , Fissura Anal/fisiopatologia , Fissura Anal/cirurgia , Humanos , Nitroglicerina/uso terapêutico , Manejo da Dor , Qualidade de Vida , Resultado do Tratamento , Vasodilatadores/uso terapêutico
3.
Dis Colon Rectum ; 62(11): 1390-1400, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31596764

RESUMO

BACKGROUND: Few data are published on perianal tuberculosis. OBJECTIVE: This study aimed to determine the best method to diagnose tuberculosis in patients with fistula-in-ano and to conduct a systematic review to determine the incidence and characteristics of tuberculosis fistula-in-ano. DATA SOURCES: The prospective study data and existing literature were derived from PubMed, Google scholar, and Scopus STUDY SELECTION:: Prospective analysis of patients with tuberculous fistula-in-ano treated between 2014 and 2018 was conducted, and a systematic review of studies describing ≥3 patients with tuberculosis fistula-in-ano was completed. INTERVENTION: Testing of tuberculosis was performed by histopathology or polymerase chain reaction of tissue or pus from the fistula tract. MAIN OUTCOME MEASURES: The primary outcomes measured were the detection rate of various tests to detect tuberculosis in fistula-in-ano and the prevalence rate of tuberculosis in simple versus complex fistulas. RESULTS: In 637 samples (410 patients) tested, tuberculosis was detected in 49 samples (43 patients). Additional samples (n = 106) sent in patients with a high index of suspicion tested positive in 14 more patients. Thus, overall, 63 samples tested positive in 57 patients (total: 743 samples in 410 patients were tested). Tuberculosis was detected in 2 of 181 patients (1.1%) in tissue (histopathology), in 28 of 341 patients (8.2%) in tissue (polymerase chain reaction), and in 19 of 115 patients (16.5%) in pus (polymerase chain reaction) samples. To detect tuberculosis, tissue (polymerase chain reaction) was significantly better than tissue (histopathology) (28/341 vs 2/181, p < 0.00001) and pus (polymerase chain reaction) was significantly better than tissue (polymerase chain reaction) (19/115 vs 28/341, p < 0.0009). Tuberculosis was significantly more common in complex fistulas than in simple fistulas (20.3% vs 7.2%, p = 0.0002). The systematic review (n = 199) highlighted that tubercular fistulas are more common in recurrent and complex fistulas and in tuberculosis endemic regions. LIMITATIONS: The true sensitivity and specificity of each testing modality could not be determined because not all patients with tuberculosis fistula-in-ano were tested by every diagnostic modality studied. CONCLUSIONS: The tuberculosis detection rate of polymerase chain reaction was significantly higher than histopathology. Among polymerase chain reaction, pus had higher detection rate than tissue. Tuberculosis was associated with more complex and recurrent fistulas.


Assuntos
Fissura Anal , Mycobacterium tuberculosis , Fístula Retal , Estreptomicina/administração & dosagem , Tuberculose Gastrointestinal , Assistência ao Convalescente/métodos , Antituberculosos/administração & dosagem , Técnicas Bacteriológicas/métodos , Técnicas Bacteriológicas/estatística & dados numéricos , Feminino , Fissura Anal/diagnóstico , Fissura Anal/epidemiologia , Fissura Anal/microbiologia , Fissura Anal/terapia , Humanos , Incidência , Índia/epidemiologia , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/genética , Mycobacterium tuberculosis/isolamento & purificação , Avaliação de Resultados em Cuidados de Saúde , Reação em Cadeia da Polimerase/métodos , Reação em Cadeia da Polimerase/estatística & dados numéricos , Fístula Retal/diagnóstico , Fístula Retal/epidemiologia , Fístula Retal/microbiologia , Fístula Retal/terapia , Recidiva , Reprodutibilidade dos Testes , Procedimentos Cirúrgicos Operatórios/métodos , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Tuberculose Gastrointestinal/diagnóstico , Tuberculose Gastrointestinal/epidemiologia , Tuberculose Gastrointestinal/fisiopatologia , Tuberculose Gastrointestinal/terapia
4.
Surg Technol Int ; 33: 105-109, 2018 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-30117130

RESUMO

BACKGROUND: Anal fissure is a common proctological condition that is usually defined as an anodermal ulcerative process starting from the posterior commissure to the dentate line. The objective of this study was to evaluate the resolution rate of anal fissure through the use of conservative management in patients grouped according to our newly proposed classification. A secondary purpose was to quantify the recurrence rates at 2-years follow-up in each group. METHODS: A retrospective analysis was carried out on patients in our general database. Diagnosis was based on symptoms, clinical observation, anal manometry and transanal ultrasounds. After application of inclusion and exclusion criteria, patients were assigned to different groups. Follow-up was carried out at 3, 6, 12 and 24 months. RESULTS: A total of 136 patients (54 female and 82 male) were included in the statistical analysis. At the end of the treatment period, all patients in groups 1 and 2 had a complete resolution of illness and a normal basal sphincterial tone, while those in groups 3 and 4 had a higher rate of recurrence at the 2-year follow-up. CONCLUSION: Based on our series, we propose a definitive non-surgical management for all group 1 and 2 anal fissures according to our protocol. For groups 3 and 4, we recommend a primary non-surgical approach with follow-up. This was a retrospective study and further randomized controlled studies will be necessary to confirm our results.


Assuntos
Tratamento Conservador , Fissura Anal/epidemiologia , Fissura Anal/terapia , Doença Crônica , Feminino , Seguimentos , Humanos , Masculino , Recidiva , Estudos Retrospectivos , Resultado do Tratamento
5.
Colorectal Dis ; 20(12): 1109-1116, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29972721

RESUMO

AIM: The aim was to determine the prevalence and risk factors of anal symptoms prepartum and postpartum. METHOD: A prospective observational cohort study was carried out in Ghent University Hospital, Belgium. Ninety-four pregnant women between their 19th and 25th week of pregnancy were included. An anal symptom questionnaire was filled in at four different times: in the second and third trimester, immediately postpartum and 3 months postpartum. Descriptive data were obtained from patient files. A proctological diagnosis was presumed on the basis of combined symptoms (i.e. rectal bleeding, anal pain and swelling). Constipation was defined by the Rome III criteria. Risk factors were identified using multivariate analysis. RESULTS: Sixty-eight per cent of the patients developed anal symptoms. The most prevalent symptom was anal pain. Constipation was reported by 60.7% during the study period. Seven women (7.9%) suffered from faecal incontinence. The most prevalent diagnoses were haemorrhoidal thrombosis (immediately postpartum), haemorrhoidal prolapse (in the third trimester and immediately postpartum) and anal fissure (not episode related). The two independent risk factors for anal complaints were constipation, with a 6.3 odds ratio (95% CI 2.08-19.37), and a history of anal problems, with a 3.9 odds ratio (95% CI 1.2-13). The Bristol Stool Chart was shown to be a reliable indicator in pregnancy and postpartum as significant correlations were observed in all study periods. CONCLUSION: Two-thirds of pregnant women have anal symptoms during pregnancy and postpartum, especially haemorrhoidal complications and anal fissure. The most important risk factor is constipation. The prevention of constipation in pregnant women is therefore highly recommended.


Assuntos
Complicações na Gravidez/epidemiologia , Doenças Retais/epidemiologia , Adulto , Bélgica/epidemiologia , Constipação Intestinal/epidemiologia , Incontinência Fecal/epidemiologia , Feminino , Fissura Anal/epidemiologia , Hemorroidas/epidemiologia , Humanos , Período Pós-Parto , Gravidez , Prevalência , Estudos Prospectivos , Fatores de Risco , Adulto Jovem
6.
ANZ J Surg ; 88(7-8): 775-778, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29205737

RESUMO

BACKGROUND: Anal fistula in association with chronic anal fissure (fissure-fistula) is infrequently described. Recognizing this association and managing both components may help prevent some treatment failures seen with chronic anal fissure. This study aims to report on the outcomes of 20 consecutive patients with fissure-fistula managed with fistulotomy and injection of botulinum A toxin. METHODS: The study is a retrospective, observational study, assessing the success of symptom resolution following fistulotomy with botulinum A toxin, in patients identified as having a chronic anal fissure with associated anal fistula. The study included all patients with this condition treated with combination treatment by a single surgeon at a tertiary care hospital between January 2013 and January 2016. RESULTS: Twenty patients with fissure-fistula treated with fistulotomy and botulinum toxin A were identified. The median cohort age was 44 years (range 25-78), with a predominance of males (80%) and posterior fissure position (80%). The most common presenting symptoms were anal pain (70%), rectal bleeding (55%), anal discharge (35%) and anal pruritus (35%). Mean follow-up was 10.5 weeks and all patients who attended follow-up appointments reported resolution of symptoms. There were no cases of incontinence and none of the cohort required further surgical intervention for the condition. CONCLUSION: Chronic anal fissure with associated anal fistula can be successfully managed with fistulotomy and injection of botulinum toxin A. Further studies would be helpful in determining if recognition and management of the fistula component in isolation with fistulotomy is as effective as fistulotomy plus botulinum A toxin.


Assuntos
Toxinas Botulínicas Tipo A/uso terapêutico , Fissura Anal/cirurgia , Fístula Retal/cirurgia , Adulto , Idoso , Canal Anal/patologia , Toxinas Botulínicas Tipo A/administração & dosagem , Doença Crônica , Terapia Combinada/métodos , Feminino , Fissura Anal/complicações , Fissura Anal/tratamento farmacológico , Fissura Anal/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares/administração & dosagem , Fármacos Neuromusculares/uso terapêutico , Fístula Retal/complicações , Fístula Retal/tratamento farmacológico , Fístula Retal/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento
7.
Dig Dis Sci ; 61(3): 861-4, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26514675

RESUMO

BACKGROUND: Chronic anal fissure (CAF) is a common problem that causes significant morbidity. Little is known about the risk factors of CAF among patients with inflammatory bowel disease (IBD). AIM: To study the clinical characteristics and prevalence of CAF among a cohort of IBD patients. METHODS: We performed a population-based study on IBD patients from the National Veterans Affairs administrative datasets from 1998 to 2011. IBD and AF were identified by ICD-9 diagnosis codes. RESULTS: We identified 60,376 patients with IBD between the ages of 18-90 years, 94% males, 59% diagnosed with ulcerative colitis (UC), and 88% were Caucasians. The overall prevalence of CAF was 4% for both males and females. African Americans (AA) were two times more likely to have CAF compared to Caucasians (8 vs. 4%; OR 2.0, 95% CI 1.6-20.2, p = 0.0001) or Hispanics (8 vs. 4.8%; OR 2.1, 95% CI 1.4-25.2, p = 0.0001). The prevalence of CAF significantly dropped with age from 7% at age group 20-50 to 1.5% at 60-90 (p = 0.0001). CD patients were two times more likely to have CAF than UC patients (6 vs. 3%; OR 1.9, 95% CI 1.5-18.2, p = 0.0001). The initial diagnosis of CAF occurred within 14 years after the initial diagnosis of IBD in 74.5% patients. CONCLUSIONS: CAF is more prevalent among IBD than what is reported in the general population and diagnosed after the diagnosis of IBD. CAF is more prevalent among patients with CD, younger patients, and AA. The current results lay the groundwork for further outcome studies relate to anal fissure such as utilization, hospitalization, and cost.


Assuntos
Colite Ulcerativa/epidemiologia , Doença de Crohn/epidemiologia , Fissura Anal/epidemiologia , Adolescente , Adulto , Afro-Americanos/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Estudos de Coortes , Feminino , Fissura Anal/etnologia , Humanos , Doenças Inflamatórias Intestinais/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Fatores de Risco , Fatores Sexuais , Fatores de Tempo , Estados Unidos/epidemiologia , Adulto Jovem
8.
Rev. esp. enferm. dig ; 107(4): 216-220, abr. 2015. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-134748

RESUMO

INTRODUCCIÓN: los antagonistas del calcio son fármacos con una excelente efectividad en el tratamiento conservador de la fisura anal crónica (FAC). OBJETIVOS: evaluar los resultados a largo plazo del tratamiento con pomada de diltiazem al 2% mediante un cuestionario telefónico. MÉTODOS: estudio descriptivo y retrospectivo desde marzo de 2004 a marzo de 2011 de pacientes con FAC y tratados con diltiazem 2%, 3 aplicaciones diarias, durante 4-6 semanas. A partir de los 12 meses se efectuó un cuestionario telefónico por personal médico ajeno al Servicio de Cirugía recogiendo datos sociodemográficos de los pacientes, sintomatología predominante, respuesta al diltiazem mediante una escala de alivio sintomático del 1 al 5 (1 = muy malo, 5 = muy bueno). Los pacientes con fracaso terapéutico se derivaron a cirugía. RESULTADOS: el estudio se completó en 166 pacientes con una edad media de 54,1 años. La localización de la FAC fue posterior en el 82,3%. La tolerancia al diltiazem fue excelente, con sólo 4 casos de efectos adversos (3 por irritación dérmica y 1 por hipotensión). Obtuvimos un alivio sintomático del 62,1% y curación de la FAC en un 51,2%, remitiendo un 33,7% a cirugía. El cuestionario evidenció que el 74,1% de los pacientes utilizó sólo dos aplicaciones al día y que a mayor número de aplicaciones mejoraban los resultados, sin alcanzar significación estadística. CONCLUSIONES: el cuestionario telefónico evidencia un alivio sintomático del 62% y una curación del 51,2% de la FAC con diltiazem 2% debiendo ser considerada como primera opción en el manejo conservador de la misma


INTRODUCTION: Calcium channel blockers have an excellent effectiveness in the conservative management of chronic anal fissure (CAF). OBJECTIVES: To assess the long-term results of management with diltiazem 2% ointment using a telephone questionnaire. METHODS: A descriptive, retrospective study from March 2004 to March 2011 in patients with CAF on diltiazem 2%, 3 applications daily for 4-6 weeks. Starting at 12 months a questionnaire was administered over the phone by medical staff outside the surgery department to record socio-demographic data, predominant manifestations, and response to diltiazem on a 5-point scale measuring symptom relief (1 = poorest, 5 = best). Patients with therapy failure were referred to surgery. RESULTS: The study was completed for 166 patients with a mean age of 54.1 years. CAF was posterior in 82.3% of subjects. Diltiazem tolerability was excellent with only 4 adverse event cases (3 skin irritation, 1 hypotension). We obtained symptom relief in 62.1% of patients and CAF healing in 51.2%, and referred 33.7% to surgery. The questionnaire showed that 74.1% of patients had used only 2 applications daily, and that results were better with an increased number of applications, albeit without statistical significance. CONCLUSIONS: The telephone questionnaire showed symptom relief for 62% and healing for 51.2% of patients with CAF on diltiazem 2%, which should be considered first-choice for the conservative management of this condition


Assuntos
Humanos , Fissura Anal/tratamento farmacológico , Diltiazem/uso terapêutico , Doença Crônica/epidemiologia , Seguimentos , Tempo/estatística & dados numéricos , Assistência de Longa Duração/estatística & dados numéricos , Telefone , Fissura Anal/epidemiologia
9.
BMC Gastroenterol ; 14: 129, 2014 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-25027411

RESUMO

BACKGROUND: Anal fissure (AF) is regarded as a common problem, but there are no published epidemiologic data, nor information on current treatment. The purpose of this study was to examine the incidence, associated comorbidities, and treatment of AF in a population-based cohort. METHODS: We conducted a retrospective analysis of all persons who were enrolled in one large regional managed care system and treated for AF during calendar years 2005-2011. All persons aged 6 years or older who had a clinic, hospitalization, or surgical procedure associated with AF were identified from utilization data. To identify comorbidities associated with AF, each case was matched by age and gender to 3 controls. RESULTS: There were 1,243 AF cases, including 721 (58%) females and 522 (42%) males; 150 (12%) of the cases occurred in children aged 6-17 years. The overall annual incidence was 0.11% (1.1 cases per 1000 person-years), but ranged widely by age [0.05% in patients 6-17 years to 0.18% in patients 25-34 years]. The incidence also varied by sex, and was significantly higher among females 12-24 years, and among males 55-64 years (P < 0.001). Comorbidities associated with AF included chronic constipation (prevalence 14.2% vs 3.6%), hypothyroidism (14.7% vs 10.4%), obesity (13.0% vs 7.7%), and solid tumors without metastasis (5.2% vs 3.7%) (P < 0.001 for all comparisons). A total of 448 were dispensed a topical prescription medication, 31 had botulinum toxin injection, and only 13 had lateral internal sphincterotomy. CONCLUSIONS: AF is a common clinical problem, and the incidence varies substantially by age and sex. Constipation, obesity, and hypothyroidism are associated comorbidities. Most patients are prescribed topical treatments, although it appears that many prescriptions are never filled. Surgical interventions for AF including botulinum toxin and lateral internal sphincterotomy are uncommon.


Assuntos
Constipação Intestinal/epidemiologia , Fissura Anal/epidemiologia , Hipotireoidismo/epidemiologia , Obesidade/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Canal Anal/cirurgia , Anestésicos Locais/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Toxinas Botulínicas Tipo A/uso terapêutico , Criança , Doença Crônica , Estudos de Coortes , Comorbidade , Feminino , Fissura Anal/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares/uso terapêutico , Estudos Retrospectivos , Fatores de Risco , Distribuição por Sexo , Vasodilatadores/uso terapêutico , Adulto Jovem
10.
BJOG ; 121(13): 1666-71, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24810254

RESUMO

OBJECTIVE: To identify the incidence and risk factors of haemorrhoids and fissures during pregnancy and after childbirth. DESIGN: Prospective observational cohort study. SETTING: University hospital and outpatient clinics in Lithuania. POPULATION: A total of 280 pregnant women followed up until 1 month after delivery. METHODS: Women were examined four times through pregnancy and after delivery; those that developed peri-anal diseases were compared with those that did not. MAIN OUTCOME MEASURES: Incidence, time and risk factors of haemorrhoids and fissures. RESULTS: In all, 123 (43.9%) women developed peri-anal disease: 1.6% in the first trimester, 61% during the third trimester, 34.1% after delivery and 3.3% 1 month after delivery; 114 (40.7%) women were diagnosed with haemorrhoids, seven (2.5%) with haemorrhoids and anal fissure and two (0.71%) with anal fissure. Ninety-nine (80.5%) women had vaginal delivery and 24 (19.5%) women had undergone caesarean section. Multivariate analysis identified personal history of peri-anal diseases (odds ratio [OR] 11.93; 95% confidence interval [95% CI] 2.18-65.30), constipation (OR 18.98; 95% CI 7.13-50.54), straining during delivery for more than 20 minutes (OR 29.75; 95% CI 4.00-221.23) and birthweight of newborn>3800 g (OR 17.99; 95% CI 3.29-98.49) as significant predictors of haemorrhoids and anal fissures during pregnancy and perinatal period. CONCLUSIONS: Haemorrhoids and fissures are common during the last trimester of pregnancy and 1 month after delivery, with constipation, personal history of haemorrhoids or fissures, birthweight of newborn>3800 g, straining during delivery for more than 20 minutes being independently associated risk factors.


Assuntos
Peso ao Nascer , Fissura Anal/epidemiologia , Hemorroidas/epidemiologia , Complicações na Gravidez/epidemiologia , Transtornos Puerperais/epidemiologia , Adolescente , Adulto , Estudos de Coortes , Constipação Intestinal/epidemiologia , Parto Obstétrico/estatística & dados numéricos , Feminino , Humanos , Incidência , Recém-Nascido , Lituânia/epidemiologia , Pessoa de Meia-Idade , Gravidez , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Adulto Jovem
12.
J Med Assoc Thai ; 96(7): 786-9, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24319847

RESUMO

OBJECTIVE: To study the association between analfissures and cow's milk allergy (CMA) in infants. METHODS AND METHOD: In a prospective study, 72 confirmed cases of CMA in infants were examined for anal fissure by pediatricians with five years' experience. A positive finding was defined as when an anal fissure was detected by at least two out of three examiners. RESULTS: Of infants with CMA with and without gastrointestinal GI symptoms, 79% and 83% had anal fissures, respectively The prevalence of anal fissure in these infants is significantly higher than in normal infants. CONCLUSION: Anal fissure may be a pathognomonic sign of cow's milk allergy in infants.


Assuntos
Fissura Anal/epidemiologia , Hipersensibilidade a Leite/complicações , Hipersensibilidade a Leite/patologia , Estudos de Casos e Controles , Feminino , Fissura Anal/patologia , Humanos , Lactente , Masculino , Prevalência , Estudos Prospectivos , Fatores de Risco
13.
Sex Transm Dis ; 40(10): 768-70, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24275725

RESUMO

We compared the spectrum of pathogens responsible for infectious proctitis between HIV-positive and HIV-negative men who have sex with men. Only 32% of men with herpes simplex virus (HSV)-associated proctitis had visible external anal ulceration.The etiology of infectious proctitis among HIV-positive and HIV-negative men is as follows: chlamydia (23.4% vs. 21.7%, P = 0.7), gonorrhea (13.4% vs. 10.8%, P = 0.5), HSV-1 (14.2% vs. 6.5%, P = 0.04), HSV-2 (22% vs. 12.3%, P = 0.03), lymphogranuloma venereum (7.8% vs. 0.7%, P = 0.004), and multiple infections (17.7% vs. 8.6%, P = 0.017). Thirty-two percent with HSV proctitis had external anal ulceration.


Assuntos
Homossexualidade Masculina , Proctite/epidemiologia , Proctite/microbiologia , Adulto , Austrália/epidemiologia , Contagem de Linfócito CD4 , Infecções por Chlamydia/complicações , Infecções por Chlamydia/epidemiologia , Fissura Anal/epidemiologia , Fissura Anal/microbiologia , Gonorreia/complicações , Gonorreia/epidemiologia , Soropositividade para HIV/complicações , Soropositividade para HIV/epidemiologia , Herpes Simples/complicações , Herpes Simples/epidemiologia , Homossexualidade Masculina/estatística & dados numéricos , Humanos , Linfogranuloma Venéreo/complicações , Linfogranuloma Venéreo/epidemiologia , Masculino , Programas de Rastreamento , Proctite/virologia , Comportamento Sexual , Carga Viral
14.
Drug Ther Bull ; 51(9): 102-4, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24030967

RESUMO

An anal fissure is defined as a linear tear or ulcer of the anal mucosa. Patients typically describe a sharp pain 'like passing broken glass' on defaecation, followed by a burning pain in the anus lasting a few hours. Pain and bleeding during and after the passage of stool are the usual presenting features. Fissures are most common in young to middle-aged adults and are also commonly seen in pregnant and postpartum women. The lifetime incidence of anal fissure is around 11%. Here, we review the evidence on the efficacy and safety of non-surgical treatments for anal fissure.


Assuntos
Fissura Anal/terapia , Hemorragia Gastrointestinal/etiologia , Dor/etiologia , Adulto , Defecação , Feminino , Fissura Anal/epidemiologia , Fissura Anal/patologia , Humanos , Incidência , Pessoa de Meia-Idade , Gravidez , Complicações na Gravidez/patologia , Complicações na Gravidez/terapia
15.
BMC Gastroenterol ; 13: 47, 2013 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-23496835

RESUMO

BACKGROUND: The principle to avoid surgery for haemorrhoids and/or anal fissure in Crohn's disease (CD) patients is still currently valid despite advances in medical and surgical treatments. In this study we report our prospectively recorded data on medical and surgical treatment of haemorrhoids and anal fissures in CD patients over a period of 8 years. METHODS: Clinical data of patients affected by perianal disease were routinely and prospectively inserted in a database between October 2003 and October 2011 at the Department of Surgery, Tor Vergata University Hospital, Rome. We reviewed and divided in two groups records on CD patients treated either medically or surgically according to the diagnosis of haemorrhoids or anal fissures. Moreover, we compared in each group the outcome in patients with prior diagnosis of CD and in patients diagnosed with CD only after perianal main treatment. RESULTS: Eighty-six CD patients were included in the study; 45 were treated for haemorrhoids and 41 presented with anal fissure. Conservative approach was initially adopted for all patients; in case of medical treatment failure, the presence of stable intestinal disease made them eligible for surgery. Fifteen patients underwent haemorrhoidectomy (open 11; closed 3; stapled 1), and two rubber band ligation. Fourteen patients required surgery for anal fissure (Botox ± fissurectomy 8; LIS 6). In both groups we observed high complication rate, 41.2% for haemorrhoids and 57.1% for anal fissure. Patients who underwent haemorrhoidectomy without certain diagnosis of CD had significantly higher risk of complications. CONCLUSIONS: Conservative treatment of proctologic diseases in CD patients has been advocated given the high risk of complications and the evidence that spontaneous healing may also occur. From these preliminary results a role of surgery is conceivable in high selected patients, but definitve conclusions can't be made. Further randomized trials are needed to establish the efficacy of the surgical approach, giving therapeutic recommendations and guidelines.


Assuntos
Doença de Crohn/complicações , Fissura Anal/etiologia , Fissura Anal/terapia , Hemorroidas/etiologia , Hemorroidas/terapia , Adolescente , Adulto , Tratamento Farmacológico , Feminino , Fissura Anal/epidemiologia , Seguimentos , Hemorroidectomia , Hemorroidas/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Proctoscopia , Estudos Prospectivos , Estudos Retrospectivos , Falha de Tratamento , Resultado do Tratamento , Adulto Jovem
17.
Ann R Coll Surg Engl ; 94(3): 170-2, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22507720

RESUMO

INTRODUCTION: Nicorandil is a commonly prescribed antianginal medication that has been found to be associated with painful anal ulceration. The incidence of this complication is unknown. We have used the best data available to us to make an estimate of this figure in a health district with a remarkably stable population of approximately 200,000 people. METHODS: using an electronic search of all letters generated from colorectal and gastroenterology clinics as well as endoscopy reports from January 2004 to November 2010, patients with anal ulceration who were taking nicorandil were identified. Other causes of ulceration were excluded by biopsy in the majority of cases. The central hospital and community pharmacy database was interrogated to estimate the number of patients who were prescribed nicorandil over a six-year period (2004-2010). RESULTS: A total of 30 patients (24 men, 6 women) with a median age of 79.5 years were identified who fulfilled the criteria of: taking nicorandil; having no other identified cause for anal ulceration; and achieving eventual healing after withdrawal of nicorandil. In the six-year period an estimated mean of 1,379 patients were prescribed nicorandil each year. The mean annual incidence of anal ulcers among nicorandil users is therefore calculated to be in the region of 0.37%. CONCLUSIONS: Anal ulceration appears to occur in approximately four in every thousand patients prescribed nicorandil each year. Prescribing physicians should explain the risk of this unpleasant complication to their patients.


Assuntos
Fissura Anal/induzido quimicamente , Nicorandil/efeitos adversos , Vasodilatadores/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Angina Pectoris/tratamento farmacológico , Inglaterra/epidemiologia , Feminino , Fissura Anal/epidemiologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade
18.
Rev. esp. enferm. dig ; 104(3): 122-127, mar. 2012. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-99771

RESUMO

Objetivo: la prevalencia de los trastornos anorrectales benignos en la población general es alta. El objetivo de este estudio es analizar la influencia de los síntomas clínicos en la precisión diagnóstica de la patología benigna anorrectal entre los diferentes especialistas y evaluar la relación entre el diagnóstico de la enfermedad y los años de experiencia profesional entre los profesionales participantes. Pacientes y métodos: se seleccionaron 7 casos típicos. En una primera entrevista, se mostró a los participantes las imágenes clínicas de cada caso y se les pidió que formularan un diagnóstico. Posteriormente, se volvió a mostrar las mismas imágenes con información clínica adicional. Dos grupos (grupo 1 = especialistas en cirugía general y digestiva y grupo 2 = especialistas de especialidades médicas con asistencia en el área de urgencias) completaron las dos fases del estudio para analizar la influencia de los síntomas clínicos en el diagnóstico final. También se analizó la relación entre la precisión diagnóstica y los años de experiencia de cada profesional. Resultados: se entrevistaron a 44 especialistas. El porcentaje de participantes que realizó un diagnóstico correcto en el grupo 1 y 2, fue respectivamente: caso 1 (absceso perianal): 100 vs. 80.6%, (p = 0,157); caso 2 (fisura anal): 92,3 vs. 51.6% (p = 0,015); caso 3 (hemorroide trombosada): 92,3 vs. 74,2% (p = 0,321); caso 4 (condiloma anal): 100 vs. 87,1% (p = 0,302); caso 5 (prolapso rectal): 100 vs. 83.9% (p = 0,301); caso 6 (prolapso hemorroidal): 92,3 vs. 29% (p = 0,001), y caso 7 (fístula perianal): 100 vs. 67,7% (p = 0,021). Se observaron diferencias en el número de los diagnósticos correctos entre grupos (p < 0,001). Globalmente, la información sobre síntomas clínicos incrementó significativamente la precisión específicamente, no observándose correlación entre experiencia profesional y precisión. Conclusiones: los síntomas clínicos son importantes para la precisión diagnóstica de la patología anorrectal benigna. La formación específica de especialistas médicos en esta patología anorrectal está claramente justificada(AU)


Aim: the prevalence of anorectal disorders in general population is high. The aim of this study was to analyze the influence of clinical symptoms on diagnostic accuracy for benign anorectal pathology among different specialists and evaluate the relation ship between diagnostic accuracy and years of professional expe rience. Methods: seven typical cases were selected. In a first interview, participants were shown images and asked to make a diagnosis. Afterwards, images with additional information (clinical symptoms) were used. Two groups (group 1 = general surgeons and group 2 = medical specialists who attended emergency department) completed both phases of the study to analyze the influence of clinical symptoms on the final diagnosis. Results: forty four specialists were interviewed. The percentage of participants making a correct diagnosis in groups 1 and 2, respectively, was as follows: case 1 (perianal abscess): 100 vs. 80.6%, (p = 0.157); case 2 (fissure): 92.3 vs. 51.6% (p = 0.015); case 3 (thrombosed hemorrhoid): 92.3 vs. 74.2% (p = 0.321); case 4 (anal condyloma): 100 vs. 87.1% (p = 0.302); case 5 (rectal prolapse): 100 vs. 83.9% (p = 0.301); case 6 (prolapsed hemorrhoid): 92.3 vs. 29% (p = 0.001), and case 7 (fistula): 100 vs. 67.7% (p = 0.021). There were significant differences in the number of correctly diagnosed cases be - tween groups (p < 0.001). Information about clinical symptoms significantly increased overall and specific accuracy. There was no correlation between experience and accuracy. Conclusions: clinical symptoms are important for diagnostic accuracy in anorectal pathology. Training in anorectal pathology in medical specialists is warranted(AU)


Assuntos
Humanos , Masculino , Feminino , Doenças do Ânus/diagnóstico , Doenças do Ânus/terapia , Doenças Retais/diagnóstico , Doenças Retais/terapia , Fissura Anal/epidemiologia , Padrões de Prática Médica/classificação , Padrões de Prática Médica/normas , Estudos Prospectivos , Cirurgia Colorretal/educação , Competência Clínica
20.
Dis Markers ; 27(6): 311-6, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20075514

RESUMO

INTRODUCTION: Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. The aim of this study was to assess the sCD26 concentration in a large cohort to evaluate its association to epidemiologic parameters and CRC-related symptoms/pathologies. SUBJECTS AND METHODS: Serum samples were collected from 2,754 putatively healthy individuals with ages ranging from 30-65 years, and with personal or familial history of polyps, CRC and/or CR symptoms. sCD26 levels were measured by ELISA. RESULTS: No association was found between the sCD26 concentration and age (< 50 and 50), the personal or familial history of polyps or CRC, rectal bleeding, haemorrhoids or diverticula. However, sCD26 was related to non-inflammatory benign pathologies (excluding rectal bleeding, changes in bowel habits, haemorrhoids, diverticula) and to inflammatory benign pathologies. DISCUSSION: Our results confirm that the sCD26 can be easily offered and evaluated in a large cohort. Additionally, the validation of sCD26 as a tumour marker for screening and case-finding purposes requires a further comparison with an established non-invasive test like the faecal occult blood.


Assuntos
Dipeptidil Peptidase 4/sangue , Gastroenteropatias/sangue , Gastroenteropatias/epidemiologia , Adulto , Fatores Etários , Idoso , Biomarcadores/sangue , Estudos de Coortes , Neoplasias Colorretais/sangue , Neoplasias Colorretais/epidemiologia , Divertículo/sangue , Divertículo/epidemiologia , Feminino , Fissura Anal/sangue , Fissura Anal/epidemiologia , Gastroenteropatias/patologia , Hemorragia Gastrointestinal/sangue , Hemorragia Gastrointestinal/epidemiologia , Trato Gastrointestinal/patologia , Trato Gastrointestinal/fisiopatologia , Hemorroidas/sangue , Hemorroidas/epidemiologia , Humanos , Inflamação/sangue , Inflamação/epidemiologia , Pólipos Intestinais/sangue , Pólipos Intestinais/epidemiologia , Síndrome do Intestino Irritável/sangue , Síndrome do Intestino Irritável/epidemiologia , Masculino , Pessoa de Meia-Idade , Reto/patologia , Reto/fisiopatologia
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