Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 280
Filtrar
1.
Cien Saude Colet ; 24(5): 1733-1742, 2019 May 30.
Artigo em Português | MEDLINE | ID: mdl-31166508

RESUMO

There has been significant growth in the number of municipal phytotherapy programs in the Unified Health System since the launch of the National Policy of Medicinal Plants in 2006. The aim of the research was to analyze how these programs are distributed throughout Brazil, how they express regional diversity and how land use can influence these programs and promote broad technical synergy (local knowledge and universal knowledge) and policy (strategy and actors) in the production, circulation, distribution and dispe sation of medicinal plants in the public health system. The analysis involved a theoretical framework of critical geography and public health, conceptual and thematic literature review, document analysis, survey of primary and secondary data along with extensive fieldwork. The results show that the growth of programs was accompanied by the choice of industrialized herbal medicines, spatially concentrated in the South and Southeast. Two phases were identified in this process: 1980-2008 characterized by horizontal actions linked to regional diversities; 2008 to the present characterized by verticalized actions on a national scale. The National Policy made it possible to increase the number of programs but did little to promote greater regional diversity.


Assuntos
Medicina Tradicional/métodos , Fitoterapia/métodos , Preparações de Plantas/administração & dosagem , Plantas Medicinais/química , Brasil , Política de Saúde , Humanos , Programas Nacionais de Saúde/organização & administração , Fitoterapia/tendências
3.
Aliment Pharmacol Ther ; 49(9): 1134-1172, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30924176

RESUMO

BACKGROUND: Functional dyspepsia, consisting of epigastric pain syndrome and postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are available and conflicting results in terms of efficacy have been reported. Consequently, nonpharmacological treatment options are increasingly being explored for functional dyspepsia. AIM: To provide an overview of current pharmacological and nonpharmacological treatment options for functional dyspepsia. METHODS: A literature search was conducted on Pubmed and other sources to identify relevant studies. RESULTS: Acid suppressive therapy reduced symptoms in 30%-70% of the patients, with higher benefit in epigastric pain syndrome and superior effectiveness for proton pump inhibitors compared to H2 -antagonists. Prokinetic agents, primarily used to treat postprandial distress syndrome, showed variable efficiency: 59%-81% responder rate for dopamine receptor antagonists, 32%-91% for serotonin-4-receptor agonists and 31%-80% for muscarinic receptor antagonists. H Pylori eradication, recommended in infected patients, was effective in 24%-82%. Refractory symptoms are addressed with neuromodulators. However, their efficacy in functional dyspepsia remains incompletely elucidated, available data showing symptom reduction in 27%-71% of the patients. Regarding herbal agents, peppermint oil reduced symptoms in 66%-91%, rikkunshito in 29%-34% and iberogast in 20%-95%. Lastly, acupuncture, cognitive behavioural therapy and hypnotherapy may help to provide symptom control, but research on their efficacy remains sparse. CONCLUSIONS: None of the available therapies is effective in the majority of patients without being associated with major side effects. Developing new treatment options is challenging due to the heterogeneity of functional dyspepsia, the lack of readily identified target mechanisms and the poor association between pathophysiological disturbances and symptoms.


Assuntos
Dispepsia/terapia , Dor Abdominal/terapia , Anti-Infecciosos/uso terapêutico , Terapias Complementares/métodos , Terapias Complementares/tendências , Dispepsia/diagnóstico , Dispepsia/fisiopatologia , Gastrite/microbiologia , Gastrite/fisiopatologia , Gastrite/terapia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos H2/uso terapêutico , Humanos , Manejo da Dor/métodos , Fitoterapia/métodos , Fitoterapia/tendências , Período Pós-Prandial/efeitos dos fármacos , Inibidores da Bomba de Prótons/uso terapêutico
5.
Int J Mol Sci ; 20(4)2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30769917

RESUMO

The aim of this Special Issue on "Plant Natural Products for Human Health" is to compile a series of scientific reports to demonstrate the medicinal potential of plant natural products, such as in vitro and in vivo activities, clinical effects, mechanisms of action, structure-activity relationships, and pharmacokinetic properties. With the global trend growing in popularity for botanical dietary supplements and phytopharmaceuticals, it is hoped that this Special Issue would serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.


Assuntos
Produtos Biológicos , Plantas Medicinais , Suplementos Nutricionais , Humanos , Fitoterapia/tendências
6.
J Ethnopharmacol ; 236: 366-392, 2019 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-30772483

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: There are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset the immune system to normal functioning. AIM OF THE STUDY: To examine the recently published medicinal plant research that matches unpublished data on ethnoveterinary medicines (EVM) used for pets in Canada (British Columbia) to see if the EVM data can provide a lead to the development of necessary drugs. MATERIALS AND METHODS: In 2003 semi-structured interviews were conducted with 60 participants who were organic farmers or holisitic medicinal/veterinary practitioners obtained using a purposive sample. A draft manual prepared from the data was then evaluated by participants at a participatory workshop that discussed the plant-based treatments. A copy of the final version of the manual was given to all research participants. In 2018, the recently published research matching the EVM data was reviewed to see if the EVM practices could serve as a lead for further research. RESULTS AND CONCLUSION: Medicinal plants are used to treat a range of conditions. The injuries treated in pets in British Columbia included abscesses (resulting from an initial injury), sprains and abrasions. Dogs were also treated with medicinal plants for rheumatoid arthritis, joint pain and articular cartilage injuries. More than 40 plants were used. Anal gland problems were treated with Allium sativum L., Aloe vera L., Calendula officinalis L., Plantago major L., Ulmus fulva Michx., Urtica dioica L. and Usnea longissima Ach. Arctium lappa, Hydrangea arborescens and Lactuca muralis were used for rheumatoid arthritis and joint pain in pets. Asthma was treated with: Linum usitatissimum L., Borago officinalis L., Verbascum thapsus L., Cucurbita pepo L., Lobelia inflata L., and Zingiber officinale Roscoe. Pets with heart problems were treated with Crataegus oxyacantha L., Cedronella canariensis (L.) Willd. ex Webb & Berth, Equisetum palustre L., Cypripedium calceolus L., Pinus ponderosa Douglas ex Lawson, Humulus lupulus L., Valeriana officinalis L., Lobelia inflata L., Stachys officinalis (L.) Trev., and Viscum album L. The following plants were used for epilepsy, motion sickness and anxiety- Avena sativa L., Valeriana officinalis, Lactuca muralis (L.) Fresen., Scutellaria lateriflora L., Satureja hortensis L., and Passiflora incarnata L. Plants used for cancer treatment included Phytolacca decandra, Ganoderma lucidum, Lentinula edodes, Rumex acetosella, Arctium lappa, Ulmus fulva, Rheum palmatum, Frangula purshiana, Zingiber officinale, Glycyrrhiza glabra, Ulmus fulva, Althea officinalis, Rheum palmatum, Rumex crispus and Plantago psyllium. Trifolium pratense was used for tumours in the prostate gland. Also used were Artemisia annua, Taraxacum officinale and Rumex crispus. This review of plants used in EVM was possible because phytotherapy research of the plants described in this paper has continued because few new pharmaceutical drugs have been developed for chronic pain and because treatments like glucocorticoid therapy do not heal. Phytotherapuetic products are also being investigated to address the overuse of antibiotics. There have also been recent studies conducted on plant-based functional foods and health supplements for pets, however there are still gaps in the knowledge base for the plants Stillingia sylvatica, Verbascum thapsus, Yucca schidigera and Iris versicolor and these need further investigation.


Assuntos
Doenças dos Animais/tratamento farmacológico , Dor Crônica/tratamento farmacológico , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Plantas Medicinais/química , Animais , Animais Domésticos , Animais Selvagens , Colúmbia Britânica , Medicina Tradicional/efeitos adversos , Medicina Tradicional/métodos , Medicina Tradicional/tendências , Fitoterapia/efeitos adversos , Fitoterapia/tendências
7.
J Zhejiang Univ Sci B ; 20(1): 9-22, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30614226

RESUMO

OBJECTIVE: The aim of this study is to summarize preclinical studies on herbal medicines used to treat cancer cachexia and its underlying mechanisms. METHODS: We searched four representing databases, including PubMed, EMBASE, the Allied and Complementary Medicine Database, and the Web of Science up to December 2016. Randomized animal studies were included if the effects of any herbal medicine were tested on cancer cachexia. The methodological quality was evaluated by the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADE) checklist. RESULTS: A total of fourteen herbal medicines and their compounds were identified, including Coptidis Rhizoma, berberine, Bing De Ling, curcumin, Qing-Shu-Yi-Qi-Tang, Scutellaria baicalensis, Hochuekkito, Rikkunshito, hesperidin, atractylodin, Sipjeondaebo-tang, Sosiho-tang, Anemarrhena Rhizoma, and Phellodendri Cortex. All the herbal medicines, except curcumin, have been shown to ameliorate the symptoms of cancer cachexia through anti-inflammation, regulation of the neuroendocrine pathway, and modulation of the ubiquitin proteasome system or protein synthesis. CONCLUSIONS: This study showed that herbal medicines might be a useful approach for treating cancer cachexia. However, more detailed experimental studies on the molecular mechanisms and active compounds are needed.


Assuntos
Caquexia/tratamento farmacológico , Neoplasias Experimentais/tratamento farmacológico , Fitoterapia/métodos , Animais , Caquexia/etiologia , Medicina Herbária/métodos , Medicina Herbária/tendências , Medicina Tradicional do Leste Asiático/métodos , Medicina Tradicional do Leste Asiático/tendências , Neoplasias Experimentais/complicações , Fitoterapia/tendências
9.
Sci China Life Sci ; 62(3): 288-308, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30128965

RESUMO

From Shen Nong's Herbal Classic (Shennong Bencao Jing) to the Compendium of Materia Medica (Bencao Gangmu) and the first scientific Nobel Prize for the mainland of China, each milestone in the historical process of the development of traditional Chinese medicine (TCM) involves screening, testing and integrating. After thousands of years of inheritance and development, herbgenomics (bencaogenomics) has bridged the gap between TCM and international advanced omics studies, promoting the application of frontier technologies in TCM. It is a discipline that uncovers the genetic information and regulatory networks of herbs to clarify their molecular mechanism in the prevention and treatment of human diseases. The main theoretical system includes genomics, functional genomics, proteomics, transcriptomics, metabolomics, epigenomics, metagenomics, synthetic biology, pharmacogenomics of TCM, and bioinformatics, among other fields. Herbgenomics is mainly applicable to the study of medicinal model plants, genomic-assisted breeding, herbal synthetic biology, protection and utilization of gene resources, TCM quality evaluation and control, and TCM drug development. Such studies will accelerate the application of cutting-edge technologies, revitalize herbal research, and strongly promote the development and modernization of TCM.


Assuntos
Genômica/métodos , Medicina Tradicional Chinesa/métodos , Metabolômica/métodos , Plantas Medicinais/genética , Plantas Medicinais/metabolismo , Proteômica/métodos , China , Medicamentos de Ervas Chinesas/uso terapêutico , Humanos , Materia Medica/uso terapêutico , Medicina Tradicional Chinesa/tendências , Fitoterapia/métodos , Fitoterapia/tendências , Plantas Medicinais/classificação , Biologia Sintética/métodos , Biologia Sintética/tendências
10.
Biomed Pharmacother ; 109: 1670-1679, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30551421

RESUMO

The application of medicinal plants are the most important biotechnological alternative in the treatment of numerous diseases, especially in developing countries, such as Brazil. Among them, we specified some specimens of the genus Cnidoscolus used as phytotherapies, with healing properties, analgesic, anti-inflammatory, antibiotic and diuretic, anticancer, among others. Such effects are possibly associated with the presence of terpenoids, alkaloids, coumarins, flavonoids phenolic compounds, among others. Thus, the objective of this work was to evaluate in the literature the studies on the phytochemical, ethnopharmacological and biotechnological applications of this genus, from 1998 to 2017. Among the sixty-one studies reported in this review, ten species are popularly utilized to pharmacological and/or biotechnological applications. Cnidoscolus aconitifolius and Cnidoscolus chayamansa are the most cited species, which were also supported by either animal or cellular investigations indicating some beneficial pharmacological actions like antioxidant, anti-inflammatory and potential cytotoxic activity. The plant parts of this genus under study are important as sources for the isolation and identification of bioactive molecules with biotechnological applications, among the many diseases treated with this phytotherapy. Given these verdicts, ethnopharmacological approaches are significant systematic tools in the determination of plant species that exhibit medicinal and nutritional purposes. The results presented here should further stimulate the development of validation studies to ensure the safe and effective use of these plant species.


Assuntos
Etnobotânica/métodos , Etnofarmacologia/métodos , Euphorbiaceae , Compostos Fitoquímicos/química , Plantas Medicinais , Animais , Bases de Dados Factuais/tendências , Etnobotânica/tendências , Etnofarmacologia/tendências , Euphorbiaceae/genética , Humanos , Compostos Fitoquímicos/genética , Compostos Fitoquímicos/isolamento & purificação , Fitoterapia/métodos , Fitoterapia/tendências , Extratos Vegetais/química , Extratos Vegetais/genética , Extratos Vegetais/isolamento & purificação , Plantas Medicinais/genética , Especificidade da Espécie
12.
ScientificWorldJournal ; 2018: 7463584, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30327583

RESUMO

The bark, leaves, and roots of Albizia adianthifolia are highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia was undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis. Preelectronic literature search of conference papers, scientific articles, books, book chapters, dissertations, and theses was carried out at the University library. Literature search revealed that A. adianthifolia is used as purgative and herbal medicine for diabetes, eye problems, gastrointestinal problems, haemorrhoids, headache, neurodegenerative disorders, reproductive problems in women, respiratory problems, wounds and pain, skin diseases, sexually transmitted infections, and ethnoveterinary medicine. Phytochemical compounds identified from the species include apocarotenoids, chalcone, dipeptide, elliptosides, essential oils, fatty acids, flavonoids, histamine, imidazolyl carboxylic acid, prosapogenins, steroids, triterpene saponins, and triterpenoids. Pharmacological studies revealed that A. adianthifolia extracts and compounds have acetylcholinesterase enzyme inhibitory, anthelmintic, antiamoebic, antibacterial, antimycobacterial, anti-sexually transmitted infections, antifungal, anti-inflammatory, antioxidant, anxiolytic, and antidepressant, cognitive-enhancing, haemolytic, hypoglycemic and antihyperglycemic, immunomodulatory, and cytotoxicity activities. Detailed studies on the pharmacokinetics, in vivo, and clinical research involving compounds isolated from A. adianthifolia and extracts of the species are required.


Assuntos
Albizzia , Etnobotânica/métodos , Compostos Fitoquímicos/uso terapêutico , Fitoterapia/métodos , Extratos Vegetais/uso terapêutico , Plantas Medicinais , África/etnologia , Analgésicos/química , Analgésicos/isolamento & purificação , Analgésicos/uso terapêutico , Animais , Etnobotânica/tendências , Fármacos Gastrointestinais/química , Fármacos Gastrointestinais/isolamento & purificação , Fármacos Gastrointestinais/uso terapêutico , Humanos , Hipoglicemiantes/química , Hipoglicemiantes/isolamento & purificação , Hipoglicemiantes/uso terapêutico , Compostos Fitoquímicos/química , Compostos Fitoquímicos/isolamento & purificação , Fitoterapia/tendências , Casca de Planta , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Folhas de Planta , Raízes de Plantas
13.
Clin Pharmacol Ther ; 104(3): 432-434, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30117148

RESUMO

Pharmacovigilance is defined as the science and activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other possible drug-related problems.1 While current models of pharmacovigilance, with their tools and methodologies, were developed for prescription drugs, safety surveillance is just as important for over-the-counter health products such as dietary supplements. The practice of pharmacovigilance is challenging in itself; however, there are unique challenges associated with dietary supplements.2.


Assuntos
Qualidade de Produtos para o Consumidor , Suplementos Nutricionais/efeitos adversos , Segurança do Paciente , Farmacovigilância , Fitoterapia/efeitos adversos , Preparações de Plantas/efeitos adversos , Controle de Qualidade , Testes de Toxicidade , Animais , Qualidade de Produtos para o Consumidor/normas , Suplementos Nutricionais/normas , Previsões , Humanos , Segurança do Paciente/normas , Fitoterapia/normas , Fitoterapia/tendências , Preparações de Plantas/normas , Melhoria de Qualidade , Medição de Risco , Testes de Toxicidade/normas , Testes de Toxicidade/tendências
14.
Sci Rep ; 8(1): 11216, 2018 07 25.
Artigo em Inglês | MEDLINE | ID: mdl-30046160

RESUMO

Natural medicines (i.e., herbal medicines, traditional formulas) are useful for treatment of multifactorial and chronic diseases. Here, we present KampoDB ( http://wakanmoview.inm.u-toyama.ac.jp/kampo/ ), a novel platform for the analysis of natural medicines, which provides various useful scientific resources on Japanese traditional formulas Kampo medicines, constituent herbal drugs, constituent compounds, and target proteins of these constituent compounds. Potential target proteins of these constituent compounds were predicted by docking simulations and machine learning methods based on large-scale omics data (e.g., genome, proteome, metabolome, interactome). The current version of KampoDB contains 42 Kampo medicines, 54 crude drugs, 1230 constituent compounds, 460 known target proteins, and 1369 potential target proteins, and has functional annotations for biological pathways and molecular functions. KampoDB is useful for mode-of-action analysis of natural medicines and prediction of new indications for a wide range of diseases.


Assuntos
Bases de Dados Factuais , Medicina Kampo/métodos , Medicina Tradicional/tendências , Fitoterapia/tendências , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/uso terapêutico , Genoma , Humanos , Medicina Kampo/tendências , Proteoma/genética
15.
J Drugs Dermatol ; 17(6): 611-617, 2018 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-29879248

RESUMO

Complementary and alternative medicine (CAM) therapies are increasing in popularity in the field of dermatology. Natural products and holistic approaches are in high demand among patients and research has begun to support their roles in acne and rosacea pathophysiology. In this article, commonly utilized biologically based complementary and alternative therapies for acne and rosacea are reviewed from an evidence-based perspective. Therapies discussed include vitamin C, nicotinamide, zinc, tea tree oil, green tea, resveratrol, curcumin, feverfew, licorice, chamomile, polypodium leucotomos, and nutrition-based approaches. J Drugs Dermatol. 2018;17(6):611-617.


Assuntos
Acne Vulgar/tratamento farmacológico , Fatores Biológicos/administração & dosagem , Terapias Complementares/tendências , Extratos Vegetais/administração & dosagem , Rosácea/tratamento farmacológico , Acne Vulgar/diagnóstico , Acne Vulgar/metabolismo , Animais , Antioxidantes/administração & dosagem , Antioxidantes/metabolismo , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/metabolismo , Fatores Biológicos/metabolismo , Terapias Complementares/métodos , Humanos , Fitoterapia/métodos , Fitoterapia/tendências , Extratos Vegetais/metabolismo , Rosácea/diagnóstico , Rosácea/metabolismo
16.
J Ethnopharmacol ; 224: 119-125, 2018 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-29800743

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Although quantitative surveys of traditional medicine markets are widely used to gain insights into the economic value, popularity or conservation status of traditional medicinal species, there have been very few repeat surveys. This study is an exception. The research was carried out in Sanyuejie Market in North-west Yunnan Province in China for three reasons. Firstly, Sanyuejie Market is large and historically significant, having operated since the Tang Dynasty (794 CE). Secondly, Sanyuejie Market is located along the "Tea-Horse Road" and "Southern Silk Road", and as such the trade from this market radiates widely throughout China and into neighboring countries such as Myanmar, Nepal and India. Thirdly, a comprehensive and systematic survey of the market was completed in 1987/88 and so this provided a unique opportunity to conduct a repeat quantitative survey. The findings, highlighting changes in species sold and the reasons why the changes have occurred, are highly relevant to ethnopharmacology at a time of substantial socio-economic and cultural change throughout China. AIM OF THE STUDY: To understand the changes in the medicinal plants trade at Sanyuejie Market between 1987/88 and 2012/13. MATERIALS AND METHODS: A quantitative ethnobotanical re-surveying involving literature review, key informant interviews and visual observations of vendor booths at the market and village investigations, was carried out in Sanyuejie. RESULTS: In 1987/88, 401 types of herbal preparations derived from 505 species in 111 families and 315 genera were sold in the market. In 2012/13, 623 herbal preparations derived from 709 species in 173 families and 451 genera were being sold. There were 105 types of herbal preparations originating from 115 species that were recorded in 1987/88 but are no longer sold at the market 25 years later. In addition, 326 types of herbal medicine preparations originating from 336 species have been added to the market since the original survey. Labor divisions have also appeared in the market. CONCLUSION: This study validates that the diversity of herbal medicines sold at Sanyuejie Market has increased and changed greatly. The growing demands for traditional herbal medicines combined with government initiatives to develop the local economy are drivers of the observed changes.


Assuntos
Comércio/tendências , Medicina Tradicional Chinesa/tendências , Fitoterapia/tendências , Plantas Medicinais , Adulto , China , Etnobotânica , Humanos , Pessoa de Meia-Idade , Inquéritos e Questionários
17.
Biomed Res Int ; 2018: 3052768, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29744355

RESUMO

Introduction: Menstrual bleeding cessation is one of the most frequent gynecologic disorders among women in reproductive age. The treatment is based on hormone therapy. Due to the increasing request for alternative medicine remedies in the field of women's diseases, in present study, it was tried to overview medicinal plants used to treat oligomenorrhea and amenorrhea according to the pharmaceutical textbooks of traditional Persian medicine (TPM) and review the evidence in the conventional medicine. Methods: This systematic review was designed and performed in 2017 in order to gather information regarding herbal medications of oligomenorrhea and amenorrhea in TPM and conventional medicine. This study had several steps as searching Iranian traditional medicine literature and extracting the emmenagogue plants, classifying the plants, searching the electronic databases, and finding evidences. To search traditional Persian medicine references, Noor digital library was used, which includes several ancient traditional medical references. The classification of plants was done based on the repetition and potency of the plants in the ancient literatures. The required data was gathered using databases such as PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, and web of knowledge. Results: In present study of all 198 emmenagogue medicinal plants found in TPM, 87 cases were specified to be more effective in treating oligomenorrhea and amenorrhea. In second part of present study, where a search of conventional medicine was performed, 12 studies were found, which had 8 plants investigated: Vitex agnus-castus, Trigonella foenum-graecum, Foeniculum vulgare, Cinnamomum verum, Paeonia lactiflora, Sesamum indicum, Mentha longifolia, and Urtica dioica. Conclusion. Traditional Persian medicine has proposed many different medicinal plants for treatment of oligomenorrhea and amenorrhea. Although just few plants have been proven to be effective for treatment of menstrual irregularities, the results and the classification in present study can be used as an outline for future studies and treatment.


Assuntos
Amenorreia/tratamento farmacológico , Medicina Herbária , Medicina Tradicional/tendências , Oligomenorreia/tratamento farmacológico , Amenorreia/epidemiologia , Feminino , Humanos , Irã (Geográfico)/epidemiologia , Medicina Tradicional/métodos , Oligomenorreia/epidemiologia , Fitoterapia/tendências , Plantas Medicinais/química , Sesamum/química
18.
Biomed Pharmacother ; 103: 381-390, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29674273

RESUMO

Esophageal cancer (EC) is one of common malignant neoplasms in the world. Due to dietary habits, environmental factors, stress and so on, larger numbers of person are diagnose with EC every year. Currently, the clinical treatment of EC mainly includes radiotherapy, chemotherapy, surgical resection alone or combined strategy. These treatment options are insufficient and often associated with a number of side effects. Medicinal herbs containing Traditional Chinese Medicine (TCM) have been used as an adjunct treatment for alleviating the side effects of chemotherapy or radiotherapy and for improving the quality of life of cancer patients. The monomer compounds obtained from medicinal herbs also exhibit potential anti-cancer activity against various type cancer cell lines including esophageal cancer, and have the ability to enhance cancer cells sensitizing to chemotherapy or radiotherapy. In this review, we summarize some monomers and composite of medicinal herbs with anti-cancer activity for EC, and elaborate their mechanism of action. Understanding the exact mechanism of their actions may provide valuable information for their possible application in cancer therapy and prevention. This is beneficial for the use and development of medicinal herbs for diseases therapy in the future.


Assuntos
Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/uso terapêutico , Neoplasias Esofágicas/tratamento farmacológico , Fitoterapia/métodos , Fitoterapia/tendências , Animais , Pontos de Checagem do Ciclo Celular/efeitos dos fármacos , Pontos de Checagem do Ciclo Celular/fisiologia , Dano ao DNA/efeitos dos fármacos , Dano ao DNA/fisiologia , Neoplasias Esofágicas/metabolismo , Neoplasias Esofágicas/patologia , Humanos , Medicina Tradicional Chinesa/métodos , Medicina Tradicional Chinesa/tendências , Plantas Medicinais/química
19.
Phytother Res ; 32(7): 1181-1210, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29575195

RESUMO

The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.


Assuntos
Apocynaceae/química , Etnofarmacologia , Fitoterapia , Extratos Vegetais , Animais , Anti-Infecciosos/farmacologia , Anti-Infecciosos/uso terapêutico , Antioxidantes/química , Antioxidantes/farmacologia , Antioxidantes/uso terapêutico , Apocynaceae/classificação , Etnofarmacologia/métodos , Etnofarmacologia/tendências , Humanos , Fitoterapia/métodos , Fitoterapia/tendências , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico
20.
Phytother Res ; 32(7): 1147-1162, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29575228

RESUMO

This paper provides a 10-year update of the 2007 systematic review of herbal medicines studied in a broad range of psychiatric disorders, including depression, anxiety, obsessive-compulsive, seasonal affective, bipolar, psychotic, phobic, somatoform, and attention-deficit hyperactivity disorders. Ovid Medline, PubMed, and the Cochrane Library were searched for herbal medicines with both pharmacological and clinical evidence of psychotropic activity. This updated review now covers clinical trial evidence for 24 herbal medicines in 11 psychiatric disorders. High-quality evidence was found to exist for the use of Piper methysticum (Kava), Passiflora spp. (passionflower) and Galphimia glauca (galphimia) for anxiety disorders; and Hypericum perforatum (St John's wort) and Crocus sativus (saffron) for major depressive disorder. Other encouraging herbal medicines with preliminary evidence include Curcuma longa (turmeric) in depression, Withania somnifera (ashwagandha) in affective disorders, and Ginkgo biloba (ginkgo) as an adjunctive treatment in Schizophrenia. Although depression and anxiety are commonly researched, many other mental disorders still require further prospective investigation. Although the previous review suggested increasing the adjunctive study of select herbal medicines with pharmaceuticals, this was still only found to sparingly occur in research designs. Aside from this, future focus should involve the incorporation of more biomarker analysis, in particular pharmacogenomics, to determine genetic factors moderating response to herbal medicines.


Assuntos
Medicina Herbária/tendências , Transtornos Mentais/tratamento farmacológico , Fitoterapia/tendências , Extratos Vegetais/uso terapêutico , Ansiedade/tratamento farmacológico , Ansiedade/epidemiologia , Depressão/tratamento farmacológico , Depressão/epidemiologia , Medicina Herbária/métodos , Humanos , Transtornos Mentais/epidemiologia , Fitoterapia/métodos , Plantas Medicinais/fisiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA