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1.
Aesthetic Plast Surg ; 43(1): 253-266, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30324295

RESUMO

Plastic surgeons are frequently asked to manage male- and female-pattern hair loss in their practice. This article discusses the epidemiology, pathophysiology, and current management of androgenetic alopecia and emphasizes more recent knowledge of stem cell niches in hair follicles that drive hair cycling, alopecia, and its treatment. The many treatment programs available for hair loss include newer strategies that involve the usage of growth factors, platelet-rich plasma, and fat to stimulate follicle growth. Future research may clarify novel biomolecular mechanisms that target specific cells that promote hair regeneration.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .


Assuntos
Alopecia/etiologia , Alopecia/cirurgia , Folículo Piloso/patologia , Cabelo/transplante , Transplante de Células-Tronco/métodos , Alopecia/patologia , Feminino , Previsões , Folículo Piloso/fisiopatologia , Humanos , Masculino , Medição de Risco , Cirurgia Plástica/métodos , Resultado do Tratamento
2.
Eur J Dermatol ; 28(4): 467-475, 2018 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-30396867

RESUMO

In mammals, desynchronized circadian rhythm leads to various biological symptoms. In skin and hair, human epidermal stem cell function in vitro is regulated by circadian oscillations, and thus contributes to tissue aging when deregulated. In mice, circadian arrhythmia of hair follicle stem cells contributes to age-related hair follicle cycling defects. Despite the well-described impact of circadian oscillations through a feedback loop involving the clock pathway on hair and skin stem cell function in vitro, little is known about the change in characteristics or regenerative properties of hHF (human hair follicle keratinocytes), hEpi (human interfollicular epidermal keratinocytes), and hHFDP (hair follicle dermal papilla stem cells) after long-term alteration of circadian rhythm in vivo. The present study was designed to asses hHF, hEpi, and hHFDP precursors and stem cell properties in response to clock pathway alteration due to long-term deregulated circadian rhythm in vivo. A clinical study protocol was designed to include two groups of women: diurnal workers (control) and shift workers (deregulated). After informed consent, two 3-mm fresh punch biopsies were taken from the occipital region of each donor (10 donors/group). Cell culture characterization, measurement of colony area, culture medium analysis, and RT-qPCR analysis were carried out. Long-term circadian rhythm deregulation affected clock pathway protein expression and correlated with alterations in hHF, hEpi, and hHFDP properties. This study provides, for the first time in humans, evidence that in vivo deregulation of the clock pathway affects regenerative properties of human skin and hair precursor cells.


Assuntos
Ritmo Circadiano/fisiologia , Folículo Piloso/fisiopatologia , Queratinócitos/fisiologia , Regeneração , Jornada de Trabalho em Turnos , Células-Tronco/fisiologia , Fatores de Transcrição ARNTL/metabolismo , Adulto , Núcleo Celular/metabolismo , Ritmo Circadiano/efeitos dos fármacos , Citoplasma/metabolismo , Feminino , Folículo Piloso/citologia , Humanos , Hidrocortisona/metabolismo , Integrina alfa6/metabolismo , Queratinócitos/metabolismo , Pessoa de Meia-Idade , Neurotensina/metabolismo , Orexinas/metabolismo , Ocitocina/metabolismo , Proteínas Circadianas Period/metabolismo , Inibidores de Proteínas Quinases/farmacologia , Pirimidinas/farmacologia , Transdução de Sinais/efeitos dos fármacos , Células-Tronco/metabolismo , beta-Endorfina/metabolismo
4.
Regen Med ; 13(6): 729-739, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30255731

RESUMO

Wound-induced hair follicle neogenesis (WIHN) is a regenerative phenomenon that occurs widely in the skin of adult mammalians. A fully functional follicle can regenerate in the center of a full-thickness wound with a large enough size. The cellular origin of this process is similar to embryonic process. Many growth and development-related pathways are involved in WIHN. Studying WIHN can deeply explore the mechanism of biological growth, development and regeneration, and can identify new treatments for hair-related disorders. Our review aims to enlighten future study by summarizing the clinical manifestation of WIHN, as well as the cellular and molecular mechanism of WIHN in recent studies.


Assuntos
Folículo Piloso/fisiopatologia , Medicina Regenerativa , Animais , Fibroblastos/metabolismo , Fibroblastos/fisiologia , Folículo Piloso/crescimento & desenvolvimento , Proteínas Hedgehog/metabolismo , Proteínas Hedgehog/fisiologia , Interleucina-6/genética , Interleucina-6/metabolismo , Interleucina-6/fisiologia , Camundongos , Camundongos Knockout , Fator de Transcrição STAT3/metabolismo , Fator de Transcrição STAT3/fisiologia , Transdução de Sinais
5.
Exp Dermatol ; 27(11): 1237-1244, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30099770

RESUMO

DECORIN is a prototypical member of the small leucine-rich proteoglycan (SLRP) family that plays important roles in numerous biological processes and cellular biological pathways. We previously showed that Decorin expression was highly enhanced in mouse dorsal hair follicles (HFs) during the anagen phase and was reduced during the catagen and telogen phases, suggesting that Decorin might modulate follicular cycling and morphogenesis. In this study, to further clarify the effects of DECORIN on hair cells and the cycling transition, an in vitro overexpression strategy and Decorin-null (Dcn-/- ) mice were used to investigate the effects of DECORIN on outer root sheath (ORS) keratinocytes. DECORIN overexpression significantly enhanced proliferation and migration in ORS keratinocytes in vitro. Moreover, DECORIN overexpression upregulated the mRNA and protein expression levels of WNT10b, ß-CATENIN and LEF1. The DECORIN overexpression-induced increase in the proliferation and migration of ORS keratinocytes was partially inhibited by a Wnt/ß-catenin inhibitor. Furthermore, Dcn-/- mice had a shortened anagen phase and lower levels of ß-catenin expression than were observed in wild-type mice in imaging and histological analyses. Taken together, these findings suggest that DECORIN promotes the proliferation and migration of ORS keratinocytes in vitro and maintains hair anagen in mice.


Assuntos
Movimento Celular/genética , Proliferação de Células/genética , Decorina/genética , Folículo Piloso/fisiopatologia , Queratinócitos/fisiologia , Adulto , Animais , Células Cultivadas , Decorina/metabolismo , Regulação para Baixo , Feminino , Expressão Gênica/genética , Folículo Piloso/citologia , Humanos , Fator 1 de Ligação ao Facilitador Linfoide/genética , Fator 1 de Ligação ao Facilitador Linfoide/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Pessoa de Meia-Idade , Biossíntese de Proteínas/genética , RNA Mensageiro/metabolismo , Transfecção , Proteínas Wnt/genética , Proteínas Wnt/metabolismo , Via de Sinalização Wnt/genética , Cicatrização , Adulto Jovem , beta Catenina/genética , beta Catenina/metabolismo
6.
J Therm Biol ; 76: 8-20, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30143301

RESUMO

This study presents a novel, thermoelectric cryotherapy cap that aims to provide effective and controlled scalp cooling to prevent hair loss for chemotherapy patients. The cap's design consists of multiple thermoelectric coolers (TECs) evenly spaced and bonded to a soft thermal interface material, tightly fitted to a patient's head. A numerical model is developed to assess the performance of alternative cap designs in relation to their ability to achieve hair follicle hypothermia. Under ideal conditions, 26.5 W of heat removal from the scalp is required to achieve the clinically-significant follicle temperature target of 22 °C. Temperature maps of the subcutaneous tissue are generated to visualise the development of hypothermic follicles, and thereby assess the effectiveness of the cap design. Transient studies show that cooling to the therapeutic temperature can be achieved within 40 min. To avoid the possibility of cold-induced tissue damage, individual thermoelectric cooling modules should not be operated at a cooling flux beyond approximately 3175 W/m2. This may be achieved with 38 modules evenly spaced in a checkerboard arrangement, each providing 0.7 W of cooling to the scalp.


Assuntos
Alopecia/prevenção & controle , Antineoplásicos/efeitos adversos , Hipotermia Induzida/instrumentação , Hipotermia Induzida/métodos , Modelos Biológicos , Couro Cabeludo/fisiopatologia , Termografia/métodos , Alopecia/induzido quimicamente , Temperatura Corporal , Feminino , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/fisiopatologia , Humanos , Masculino , Couro Cabeludo/efeitos dos fármacos , Dispositivos Eletrônicos Vestíveis
9.
Int J Dermatol ; 57(12): 1417-1424, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29377091

RESUMO

Chemotherapy-induced alopecia (CIA) is one of the most troubling long-lasting side effects of cancer treatment. An estimated 65% of patients undergoing classic chemotherapy will experience hair loss, which is an extremely upsetting adverse event for many. CIA has been traditionally considered to be a diffuse, nonscarring alopecia; however, there are increasing reports of permanent hair loss post chemotherapy. Despite its large impact on patients, there are few proven treatments for CIA. Recent advancements in understanding the pathogenesis of hair loss are promising novel preventative and therapeutic strategies. Currently, scalp cooling during chemotherapy is the most effective preventive intervention with response rates ranging from 50 to 80%. To avoid patient morbidity, clinicians should be aware of the pathogenesis of CIA, characteristic patterns of hair loss associated with specific drug regimens, preventive measures that may be taken, and therapeutic options post chemotherapy. The following represents an updated systematic review of CIA, including characteristic clinical patterns, pathophysiology of the disease, therapeutic approaches, as well as a cost-effective analysis to assess the significance of this toxicity.


Assuntos
Alopecia/induzido quimicamente , Alopecia/prevenção & controle , Antineoplásicos/efeitos adversos , Folículo Piloso/fisiopatologia , Alopecia/diagnóstico , Alopecia/tratamento farmacológico , Animais , Anti-Hipertensivos/uso terapêutico , Bimatoprost/uso terapêutico , Crioterapia , Humanos , Minoxidil/uso terapêutico , Couro Cabeludo
10.
Dermatol Ther ; 31(1)2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29193553

RESUMO

Approximately 40% of women experience excessive hair shedding during styling (e.g., hair brushing). Previously, we demonstrated that topically applied phenylephrine, a potent α1 adrenergic receptor agonist, can be used to contract the arrector pili muscle of the follicular unit; thus, increasing the force required to pluck hair and reducing shedding during brushing. While demonstrating efficacy, phenylephrine has several drawbacks when applied to the scalp, including the possibility cardiovascular events. We hypothesized that a high concentration of a weak α1 agonist would allow for: (a) rapid penetration through the stratum corneum eliciting a quick response; (b) a low probability of cardiac adverse events owing to the low receptor binding affinity; and (c) an efficacy of the weak α1 agonist similar to that of phenylephrine at the local site of application. Accordingly, we developed a novel topical solution, AB-102, containing a high concentration of a weak α1 agonist. Several studies were conducted to test the safety and efficacy of AB-102. In a dose escalating safety study, utilizing a wearable holter monitor, we observed no cardiac or hemodynamic adverse events. In addition, in a controlled efficacy study, AB-102 reduced the number of hairs shed during brushing by up to 77% (average of 38%).


Assuntos
Agonistas de Receptores Adrenérgicos alfa 1/administração & dosagem , Alopecia/prevenção & controle , Folículo Piloso/efeitos dos fármacos , Piloereção/efeitos dos fármacos , Sinefrina/administração & dosagem , Administração Tópica , Adolescente , Agonistas de Receptores Adrenérgicos alfa 1/efeitos adversos , Adulto , Alopecia/diagnóstico , Alopecia/fisiopatologia , Pressão Sanguínea/efeitos dos fármacos , Eletrocardiografia Ambulatorial , Feminino , Folículo Piloso/fisiopatologia , Remoção de Cabelo , Frequência Cardíaca/efeitos dos fármacos , Humanos , Couro Cabeludo , Sinefrina/efeitos adversos , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
11.
J Drugs Dermatol ; 16(11): s135-s140, 2017 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-29141068

RESUMO

Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways. However, research points to similar dysregulation of intrinsic signaling pathways within follicle physiology that span the hair loss disorder spectrum - with a common inflammatory component identified in most hair loss pathogenesis, including that of androgenetic alopecia (AGA).

J Drugs Dermatol. 2017;16(11 Suppl):s135-140.

.


Assuntos
Alopecia/tratamento farmacológico , Folículo Piloso/fisiopatologia , Alopecia/fisiopatologia , Desenho de Fármacos , Drogas em Investigação , Humanos , Inflamação/fisiopatologia
12.
Exp Dermatol ; 26(11): 1083-1090, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-28480983

RESUMO

Growing bodies of data show that psychological stress can be associated with hair loss and vitiligo. Researchers have revealed that stress could indeed inhibit hair growth in vivo, but the relationship between chronic stress and melanogenesis remains unknown. In this study, we established two types of stress models, chronic restraint stress (CRS) and chronic unpredicted mild stress (CUMS) mice models, and explored the possible role of stress in mice hair follicle melanogenesis. We found that stress changed hippocampal morphology, decreased 5-HT level in brain and skin and down-regulated 5-HT1A receptor expression in hippocampal CA1 region and skin. The alterations of 5-HT and 5-HT1A receptor might be a threshold of central stress to associate with the behaviour changes. Both two stresses caused cellular damage of melanocytes and inhibition of keratinocytes proliferation in HF, which made the synthetic pigment loss. CRS which was considered primarily as a "psychological" stressor had the lower melanin production in HF, as well as the level of 5-HT in skin was down-regulated more than those in CUMS group.


Assuntos
Cor de Cabelo , Folículo Piloso/fisiopatologia , Hipocampo/metabolismo , Melaninas/biossíntese , Serotonina/metabolismo , Estresse Psicológico/fisiopatologia , 8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia , Animais , Comportamento Animal , Linhagem Celular Tumoral , Proliferação de Células , Doença Crônica , Cicloexanos/farmacologia , Modelos Animais de Doenças , Folículo Piloso/metabolismo , Folículo Piloso/patologia , Hipocampo/patologia , Oxirredutases Intramoleculares/metabolismo , Queratinócitos/fisiologia , Masculino , Melaninas/sangue , Melanócitos/patologia , Glicoproteínas de Membrana/agonistas , Glicoproteínas de Membrana/antagonistas & inibidores , Glicoproteínas de Membrana/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Monofenol Mono-Oxigenase/metabolismo , Oxirredutases/antagonistas & inibidores , Oxirredutases/metabolismo , Piperazinas/farmacologia , Biossíntese de Proteínas/efeitos dos fármacos , Células Piramidais/patologia , Receptor 5-HT1A de Serotonina/metabolismo , Antagonistas da Serotonina/farmacologia , Agonistas do Receptor de Serotonina/farmacologia , Pele/metabolismo
13.
Exp Dermatol ; 26(6): 524-526, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28423238

RESUMO

In addition to genetics and androgens, novel factors could play a role in androgenetic alopecia (AGA). This study aims to investigate the association between plasma leptin level with the risk and severity of AGA in men. Forty-eight subjects were enrolled including 29 AGA and 19 non-AGA subjects. The plasma leptin level was significantly higher in AGA subjects, compared to non-AGA subjects (4.45 vs 2.76 ng/mL, P<.05). A higher plasma leptin levels were positively correlated with the risk of developing AGA in multivariate logistic analysis (odds ratio=2.77, P<.05). Leptin from the circulation might impact the development of AGA.


Assuntos
Alopecia/sangue , Alopecia/diagnóstico , Folículo Piloso/fisiopatologia , Leptina/sangue , Adipócitos/citologia , Adulto , Alopecia/genética , Androgênios/metabolismo , Índice de Massa Corporal , Estudos de Casos e Controles , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Obesidade/metabolismo , Razão de Chances , Risco , Pele/metabolismo , Adulto Jovem
14.
Exp Dermatol ; 26(6): 472-477, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28266743

RESUMO

The hair follicle is a mini-organ endowed with a unique structure and cyclic behaviour. Despite the intense research efforts which have been devoted at deciphering the hair follicle biology over the past 70 years, one must admit that hair follicle remains an enigma. In this brief review, various aspects of hair follicle biology will be addressed, and more importantly, unsolved questions and new possible research tracks will be highlighted, including hair follicle glycobiology and exosome-mediated cell-cell interactions. Even though bricks of knowledge are solidly being acquired, an integrative picture remains to emerge. One can predict that computer science, algorithms and bioinformatics will assist in fostering our understanding hair biology.


Assuntos
Doenças do Cabelo/genética , Doenças do Cabelo/fisiopatologia , Folículo Piloso/fisiopatologia , Cabelo/fisiologia , Algoritmos , Alopecia/fisiopatologia , Animais , Comunicação Celular , Biologia Computacional , Exossomos/metabolismo , Estudo de Associação Genômica Ampla , Glicômica , Humanos , Lipídeos/química , Camundongos , Modelos Biológicos , Pesquisa Médica Translacional
15.
Nat Rev Dis Primers ; 3: 17011, 2017 Mar 16.
Artigo em Inglês | MEDLINE | ID: mdl-28300084

RESUMO

Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair-bearing sites. Patchy alopecia areata affecting the scalp is the most common type. Alopecia areata affects nearly 2% of the general population at some point during their lifetime. Skin biopsies of affected skin show a lymphocytic infiltrate in and around the bulb or the lower part of the hair follicle in the anagen (hair growth) phase. A breakdown of immune privilege of the hair follicle is thought to be an important driver of alopecia areata. Genetic studies in patients and mouse models have shown that alopecia areata is a complex, polygenic disease. Several genetic susceptibility loci were identified to be associated with signalling pathways that are important to hair follicle cycling and development. Alopecia areata is usually diagnosed based on clinical manifestations, but dermoscopy and histopathology can be helpful. Alopecia areata is difficult to manage medically, but recent advances in understanding the molecular mechanisms have revealed new treatments and the possibility of remission in the near future.


Assuntos
Alopecia em Áreas/diagnóstico , Folículo Piloso/anatomia & histologia , Alopecia em Áreas/fisiopatologia , Exposição Ambiental/efeitos adversos , Cabelo/patologia , Folículo Piloso/patologia , Folículo Piloso/fisiopatologia , Humanos , Microbiota , Couro Cabeludo/patologia , Estresse Psicológico/complicações
16.
Arch Dermatol Res ; 309(3): 191-202, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28229231

RESUMO

Intense pulsed light (IPL) has been used for years in hair reduction; however, no previous studies discussed quantitative histological and immunohistochemical changes of hair follicles after IPL. Accordingly, this study aims to objectively quantify histological and immunohistochemical changes of hair follicles after IPL hair reduction. Right axillae of 21 volunteers were subjected to 6 IPL sessions using Quanta system IPL and evaluated at 1 week and 1 month after last session (i.e., 3 and 4 months from the start of treatment, respectively) in comparison to baseline and left control axillae. Using hair count, histological and immunohistochemical assessment of vertical and serial transverse sections coupled with computerized morphometric analysis, determination of hair reduction percentage, measurement of hair shaft (HS) diameter, calculation of percentage of hair follicle types and quantitative evaluation of PCNA, Ki67 and P53 markers were performed. After IPL, there was significant decrease of hair count, HS diameter, percentage of terminal anagen follicles, terminal/vellus (T/V) ratio, anagen/telogen (A/T) ratio and expression of PCNA and Ki67; however, significant increase of percentage of terminal telogen and total vellus follicles with vellus-like type and P53 expression was identified. So, reduction of hair number and thickness occurred after IPL by induction of telogenesis and miniaturization through decreased hair follicle proliferation and increase in DNA damage that could favor apoptosis.


Assuntos
Folículo Piloso/fisiopatologia , Remoção de Cabelo/métodos , Antígeno Ki-67/metabolismo , Fototerapia/métodos , Antígeno Nuclear de Célula em Proliferação/metabolismo , Proteína Supressora de Tumor p53/metabolismo , Adolescente , Adulto , Feminino , Humanos , Luz , Adulto Jovem
17.
J Dermatol ; 44(4): 386-393, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27711995

RESUMO

Alopecia areata (AA) affects anagen hair follicles, resulting in non-scarring hair loss. Since introduced by Huang et al., superficial cryotherapy has been accepted as a considerable primary therapeutic modality for AA. The aim of this study was to objectively clarify the therapeutic efficacy and safety of superficial hypothermic cryotherapy for treatment of AA. Medical records of 353 patients from 1993 to 2014 were retrospectively analyzed. According to the response to the superficial cryotherapy, patients were categorized into four groups: "marked", "partial", "poor" and "no recovery". The marked and partial recovery groups were considered as responders. The proportions of the responders among patient subgroups which were defined by various patients, disease, and treatment factors were compared. Of the patients, 60.9% were classified as responders after 3 months of superficial hypothermic cryotherapy. The proportion of the responders were higher when the treatment interval was 2 weeks or less and in the incipient disease stage, with statistical significance. No severe side-effects other than mild pain and pruritus were reported. In conclusion, superficial cryotherapy is an effective and safe therapeutic modality for AA. Especially when the treatment interval is 2 weeks or less and in the first occurrence of the disease, the therapeutic outcome is superior.


Assuntos
Alopecia em Áreas/terapia , Crioterapia/efeitos adversos , Crioterapia/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Folículo Piloso/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Dor/etiologia , Prurido/etiologia , Estudos Retrospectivos , Couro Cabeludo , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
19.
Med Hypotheses ; 95: 39-44, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27692164

RESUMO

Type 2 Diabetes mellitus (DM2) includes a continuum of metabolic disorders characterized by hyperglycemia that causes several chronic long-term complications such as coronary artery disease, peripheral arterial disease, nephropathy, and neuropathy. The hair follicle could reveal signs of early vascular impairment, yet its relationship to early metabolic injuries has been largely ignored. We propose that in earlier stages of the continuum of DM2-related metabolic disorders, a group of susceptible patients who do not yet meet the diagnostic criteria to be considered as persons with DM2 may present chronic vascular impairment and end organ damage, including hair follicle damage, which can be evaluated to identify an early risk marker. This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. In order to test this hypothesis, studies are required to evaluate if hair follicle characteristics are related to and can predict hyperglycemic complications, and if they do so, which feature of the hair follicle, such as hair growth, best characterizes such DM2-related conditions. If this hypothesis were proven to be true, significant advances towards a personalized approach for early prevention strategies and management of DM2 would be made. By focusing on the hair follicles, early stages of metabolic-related organ damage could be identified using non-invasive low-cost techniques. In so doing, this approach could provide early identification of DM2-susceptible individuals and lead to the early initiation of adequate primary prevention strategies to reduce or avoid the onset of large internal organ damage.


Assuntos
Diabetes Mellitus Tipo 2/diagnóstico , Folículo Piloso/fisiopatologia , Envelhecimento , Alopecia/complicações , Aminoácidos/sangue , Aminoácidos/metabolismo , Doenças Autoimunes/complicações , Diabetes Mellitus Tipo 2/sangue , Progressão da Doença , Grupos Étnicos , Feminino , Cabelo/fisiologia , Humanos , Hiperglicemia/sangue , Resistência à Insulina , Masculino , Modelos Teóricos , Projetos de Pesquisa , Risco , Estações do Ano
20.
Med Hypotheses ; 93: 53-4, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27372856

RESUMO

Amputees may suffer from dermatoses such as folliculitis and pilonidal sinus caused by pressure on the stump in hairy parts of the skin. These conditions commonly cause pain and need treatment that result in abandonment of prosthesis use and disrupt the patient's daily living activities. We believe these conditions may be easily, effectively and cheaply prevented with the use of intense pulsed light technology, which is produced for home epilation. The use of this kind of epilator in the early period post-amputation may prevent the development of folliculitis and pilonidal sinus. This application may also be cost-effective in long term.


Assuntos
Amputados , Foliculite/terapia , Folículo Piloso/fisiopatologia , Remoção de Cabelo/métodos , Seio Pilonidal/terapia , Dermatopatias/terapia , Amputação , Feminino , Foliculite/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Teóricos , Dor/prevenção & controle , Seio Pilonidal/complicações , Pressão , Dermatopatias/complicações
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