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3.
An Bras Dermatol ; 95(2): 238-240, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32146012

RESUMO

Some epidermal alterations in measles has been described, such as keratinocytes apoptotic, parakeratosis, giant-cell formation, intranuclear and cytoplasmic inclusions, dyskeratosis, spongiosis, and intracellular edema. The authors report for the first time in human a case of measles with the presence of multinucleated giant cells in the hair follicle and dyskeratosis in acrosyringium.


Assuntos
Epiderme/patologia , Folículo Piloso/patologia , Sarampo/patologia , Biópsia , Criança , Células Gigantes/patologia , Humanos , Queratinócitos/patologia , Masculino , Paraceratose/patologia
4.
An Bras Dermatol ; 95(2): 217-220, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32173139

RESUMO

Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. We present three cases of melanonychia of different etiologies with subungual follicular inclusions, an association that has not been well described and with an indefinite pathogenesis.


Assuntos
Folículo Piloso/patologia , Melanose/patologia , Doenças da Unha/patologia , Adulto , Dermoscopia , Folículo Piloso/diagnóstico por imagem , Humanos , Masculino , Melanose/diagnóstico por imagem , Pessoa de Meia-Idade , Doenças da Unha/diagnóstico por imagem , Unhas/patologia , Ultrassonografia
5.
Arq Bras Oftalmol ; 83(2): 153-156, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32159597

RESUMO

A 45-year-old man presented with a 3-month history of a mass located in the caruncle of his right eye. An incisional biopsy had been performed one month prior by another specialist, and the histopathology report showed basal cell carcinoma. The mass was completely excised with a 2 mm safety margin, and the large conjunctival defect was reconstructed with one sheet of amniotic membrane allograft. A histological diagnosis of pilomatrix carcinoma was established. To prevent recurrence after surgery, we added bevacizumab (25 mg/mL, 1.25 mg/mL per drop) eye drops four times per day for three months. At the one-year follow-up, the patient showed no evidence of local recurrence or distant metastasis after initial excision and remains under close follow-up. Pilomatrix carcinoma should be considered in the differential diagnosis of a caruncular mass.


Assuntos
Carcinoma Basocelular/patologia , Neoplasias da Túnica Conjuntiva/patologia , Doenças do Aparelho Lacrimal/patologia , Pilomatrixoma/patologia , Biópsia , Carcinoma Basocelular/cirurgia , Neoplasias da Túnica Conjuntiva/cirurgia , Doenças do Cabelo/patologia , Folículo Piloso/patologia , Humanos , Doenças do Aparelho Lacrimal/cirurgia , Masculino , Pessoa de Meia-Idade , Pilomatrixoma/cirurgia
7.
Clin Nucl Med ; 45(2): 146-147, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31833930

RESUMO

We describe a rare case of metastatic pilomatrix carcinoma with distant metastases 10 months after diagnosis. A 37-year-old woman was diagnosed with pilomatrix carcinoma by excisional biopsy from the occipital region and referred to us for F-FDG PET/CT examinations at the time of diagnosis and 10 months after diagnosis. The first PET/CT did not show any pathological activity, whereas the second PET/CT showed multiple intensive F-FDG uptakes in the right lung parenchyma, right hemithorax pleura, liver, and bones.


Assuntos
Carcinoma/diagnóstico por imagem , Folículo Piloso/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Neoplasias Cutâneas/diagnóstico por imagem , Adulto , Carcinoma/patologia , Feminino , Fluordesoxiglucose F18 , Folículo Piloso/patologia , Humanos , Metástase Neoplásica , Compostos Radiofarmacêuticos , Neoplasias Cutâneas/patologia
8.
Clin Exp Dermatol ; 45(1): 63-72, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31017678

RESUMO

We present a series of 13 patients with clinical and histological features of both folliculitis decalvans (FD) and lichen planopilaris (LPP), either concomitantly, or sequentially as the clinical phenotype changed over time. This biphasic presentation of FD-LPP is not as uncommon as would be expected from the lack of description in the literature. We discuss current theories about the pathogenesis of both LPP and FD, and speculate how abnormal immune responses may either predispose to secondary bacterial infection or be influenced by dysbiosis of the skin/hair follicle microbiome, resulting in inflammation and permanent hair follicle damage.


Assuntos
Foliculite/complicações , Folículo Piloso/patologia , Líquen Plano/complicações , Adulto , Idoso , Feminino , Foliculite/patologia , Humanos , Líquen Plano/patologia , Masculino , Pessoa de Meia-Idade , Fenótipo
9.
Am J Dermatopathol ; 42(1): 1-10, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31880634

RESUMO

INTRODUCTION: Pityriasis lichenoides (PL) is an infrequent skin disorder. The clinical manifestations are usually specific enough for a reliable diagnosis, although the histopathological assessment of a biopsy is sometimes needed to differentiate between PL and a range of other diseases. The objectives of this study were to review cases of PL managed in our hospital, confirm the classical histopathological features of PL, and identify signs that may be of value in the diagnosis of PL. MATERIALS AND METHODS: All cases of PL assessed in our pathology department between January 2007 and December 2017 were retrieved, and all slides were reviewed. Cases were selected only if a diagnosis of PL was initially suggested by a dermatologist and then confirmed by the histopathological assessment. RESULTS: Seventy-one cases met the study criteria. The following features were almost always present: vacuolar changes or necrotic keratinocytes (100%), both superficial and deep lymphocytic infiltrates (99%), and the infiltration of lymphocytes into the adnexal epithelium (97%). The inflammatory cells were always small- to medium-sized lymphocytes. There were no eosinophilic infiltrates. Superficial perivascular and/or intraepidermal red blood cells were observed in 83% of cases. DISCUSSION: We highlighted the presence of a deep dermal lymphocytic infiltrate, with a "T-shaped" periadnexal arrangement along the full length of the follicular and sudoral epithelia. This might be a feature that enables the differentiation of PL from other diseases. Our findings also prompted a number of physiopathological hypotheses for PL. CONCLUSIONS: Our present results confirmed the classical histological aspects of PL and provided some useful new diagnostic features.


Assuntos
Pitiríase Liquenoide/patologia , Adolescente , Criança , Feminino , Folículo Piloso/patologia , Humanos , Masculino , Pitiríase Liquenoide/diagnóstico , Adulto Jovem
10.
BMJ Case Rep ; 12(12)2019 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-31818896

RESUMO

A 62-year-old woman came to our hospital with complaints of painless gradual increase in dark coloured mass along inner canthus of the right eye. The surface of the mass was rough with a well-defined margin. No other systemic abnormality was detected. Wide margin excision was done and the excised mass was sent for histopathological examination. No skin grafting was done and the raw area was left for self-healing. In the next 3 weeks, skin growth over the raw area was observed and it was cosmetically acceptable. Histopathological examination revealed well-circumscribed tissue composed of aggregation of basaloid cells suggestive of trichoblastoma. Immunohistochemistry revealed positive staining of CD34 and CD10. Trichoblastoma is a rare entity seen in our clinical practice. Hence, a patient presenting with darker masses trichoblastoma can be considered as differential diagnosis.


Assuntos
Carcinoma Basocelular/diagnóstico , Neoplasias Palpebrais/diagnóstico , Folículo Piloso/patologia , Antígenos CD34/análise , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Neoplasias Palpebrais/patologia , Neoplasias Palpebrais/cirurgia , Feminino , Folículo Piloso/cirurgia , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neprilisina/análise , Resultado do Tratamento
11.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(10): 850-854, dic. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-185607

RESUMO

El tumor pilar proliferante es una neoplasia cutánea rara, que se deriva de la vaina de la raíz externa de los folículos pilosos con un amplio espectro en su presentación dado a que puede variar desde la benignidad hasta la malignidad con alta probabilidad de recurrencia posterior a su escisión. En este artículo describimos la experiencia del Hospital de San José en Bogotá, Colombia en el manejo de 3 tumores pilares proliferantes, con una presentación clínica y un comportamiento patológico distinto


A proliferating pilar tumor is a rare skin neoplasm that arises from the outer root sheath of a hair follicle. Presentation varies widely, as the tumor can be benign or malignant and has a high probability of recurring after excision. We report our experience managing 3 proliferating pilar tumors with different clinical presentations and pathology findings at Hospital de San José, Bogota, Colombia


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias Cutâneas/diagnóstico , Diagnóstico Diferencial , Couro Cabeludo/patologia , Cisto Epidérmico/patologia , Folículo Piloso/patologia , Imuno-Histoquímica , Queratinócitos/patologia , Neoplasias Cutâneas/patologia
13.
An Bras Dermatol ; 94(5): 608-611, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777364

RESUMO

Dissecting cellulitis is an inflammatory, chronic, and recurrent disease of the hair follicles that mainly affects young Afro-descendent men. Trichoscopy is a method of great diagnostic value for disorders of the scalp. Clinical and trichoscopic findings of dissecting cellulitis are heterogeneous and may present features common to non-cicatricial and scarring alopecia. This article presents the trichoscopic findings of dissecting cellulitis that help in the diagnosis and consequent institution of the appropriate therapy and better prognosis of the disease.


Assuntos
Celulite (Flegmão)/diagnóstico por imagem , Celulite (Flegmão)/patologia , Dermoscopia/métodos , Folículo Piloso/diagnóstico por imagem , Folículo Piloso/patologia , Dermatoses do Couro Cabeludo/diagnóstico por imagem , Dermatoses do Couro Cabeludo/patologia , Dermatopatias Genéticas/diagnóstico por imagem , Dermatopatias Genéticas/patologia , Eritema/diagnóstico por imagem , Eritema/patologia , Cabelo/diagnóstico por imagem , Cabelo/patologia , Humanos
15.
Artigo em Inglês | MEDLINE | ID: mdl-31584017

RESUMO

Background: Trichoscopy is a reliable instrument for diagnosis and for tracking therapy-related changes in female pattern hair loss (FPHL). Videodermoscopic diagnosis of FPHL has been established, which requires fine measurements of hair-related parameters; the method requires an expensive equipment/digital program. Aim: To determine whether a low-cost, simple USB dermoscope can ascertain the hair-related changes in early FPHL. Methods: An age-matched, cross-sectional study was performed over 3 years on subjects with less than 6-month history of hair loss and without an obvious broadening of midline hair parting. Trichoscopic analysis of the frontal and occipital scalp of the study subjects were performed, using a USB-connected dermoscope. The subjects were analyzed for the presence of microscopic hair changes in the form of anisotrichosis, vellus-like hair, single hair follicle unit, peri-pilar sign and yellow dots. Results: A total of 230 cases and 230 controls were analyzed. The dermoscopic hair changes were found to be significantly associated with the frontal scalp zone of cases. Limitations: Histopathological evaluation of the cases was not done. Conclusion: Microscopic changes recorded with the help of a simple USB dermoscope are helpful in establishing a diagnosis of FPHL even in early disease.


Assuntos
Alopecia/diagnóstico , Alopecia/economia , Dermoscopia/economia , Recursos em Saúde/economia , Couro Cabeludo/patologia , Adolescente , Adulto , Estudos Transversais , Dermoscopia/métodos , Feminino , Folículo Piloso/patologia , Humanos , Adulto Jovem
16.
An Bras Dermatol ; 94(4): 416-421, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644613

RESUMO

BACKGROUND: Frontal fibrosing alopecia is a condition of unknown origin, histologically similar to classic lichen planopilaris and generally observed in postmenopausal women with alopecia of the frontal-temporal hairline. OBJECTIVES: To describe the clinical, dermatoscopic, and histopathological characteristics and the treatment used in patients who have frontal fibrosing alopecia at the Alopecia Outpatient Clinic in a university hospital. METHODS: Retrospective descriptive study performed by reviewing medical charts and biopsies of the scalp. RESULTS: Sixteen patients were analyzed, all of them female, 93.75% of them postmenopausal, and 56.25% brown-skinned. All had frontal alopecia (100%), followed by temporal alopecia (87.5%) and madarosis (87.5%). On dermatoscopy, perifollicular erythema and tubular scales were found as a sign of disease activity. Of the patients, 68.75% had associated autoimmune diseases, including lupus, thyroid disease and vitiligo. Of the 13 biopsies from 8 patients, 10 showed microscopic aspects compatible with frontal fibrosing alopecia. Laboratory tests did not show major abnormalities and minoxidil was the most used treatment. STUDY LIMITATION: Data collection limited by the study's retrospective design associated to flaws while filling in the medical charts and absence in standards to the collection and processing of the pathology and histopathological examination. CONCLUSIONS: A demographical, clinical, and histopathological description of 16 patients diagnosed with frontal fibrosing alopecia, which remains a challenging disease, of unknown origin, and frequently associated with autoimmune diseases. This study reinforces literary findings. However, more research is needed to establish the pathogenesis and effective treatments.


Assuntos
Alopecia/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Alopecia/tratamento farmacológico , Biópsia , Dermoscopia/métodos , Feminino , Fibrose , Folículo Piloso/patologia , Hospitais Universitários , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Couro Cabeludo/patologia
17.
An. bras. dermatol ; 94(5): 608-611, Sept.-Oct. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1054872

RESUMO

Abstract Dissecting cellulitis is an inflammatory, chronic, and recurrent disease of the hair follicles that mainly affects young Afro-descendent men. Trichoscopy is a method of great diagnostic value for disorders of the scalp. Clinical and trichoscopic findings of dissecting cellulitis are heterogeneous and may present features common to non-cicatricial and scarring alopecia. This article presents the trichoscopic findings of dissecting cellulitis that help in the diagnosis and consequent institution of the appropriate therapy and better prognosis of the disease.


Assuntos
Humanos , Dermatoses do Couro Cabeludo/diagnóstico por imagem , Celulite (Flegmão)/patologia , Celulite (Flegmão)/diagnóstico por imagem , Folículo Piloso/patologia , Folículo Piloso/diagnóstico por imagem , Dermoscopia/métodos , Dermatoses do Couro Cabeludo/patologia , Dermatopatias Genéticas/patologia , Dermatopatias Genéticas/diagnóstico por imagem , Eritema/diagnóstico , Eritema/patologia , Cabelo/patologia , Cabelo/diagnóstico por imagem
19.
Rev. clín. med. fam ; 12(3): 143-146, oct. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-186804

RESUMO

Los pilomatrixomas son neoplasias infrecuentes del tejido folicular. En el 70% de los casos suelen aparecer en las primeras dos décadas de vida, y con mayor frecuencia se distribuyen en cabeza y cuello. Normalmente se dan de forma aislada, siendo de muy rara aparición los pilomatrixomas múltiples, los cuales están relacionados con síndromes genéticos, especialmente con la distrofia miotónica de Steinert que puede presentarse tiempo después de la aparición de estos, por lo que precisan seguimiento. Es importante desde Atención Primaria la correcta identificación y derivación al especialista en Dermatología de estas lesiones, ya que su tratamiento es la extirpación y deben descartarse y hacerse seguimiento de posibles síndromes asociados. Existen casos descritos de malignización de pilomatrixomas (pilomatrixcarcinoma). Presentamos un caso de pilomatrixomas múltiples visto en consultas de Atención Primaria, en el cual se revisa la patología y se plantea el despistaje de síndromes asociados. Aunque, si bien el diagnóstico de certeza es histológico y su tratamiento quirúrgico, es el médico de familia el primer especialista que atiende al paciente y su correcta orientación diagnóstica basada en la exploración clínica, correlación, y derivación puede acelerar y prevenir las posibles complicaciones de los síndromes asociados


Pilomatrixomas are infrequent neoplasms of the follicular tissue. In 70% of cases they usually appear in the first two decades of life, and are most often distributed over the head and neck. They usually occur in isolation, so multiple pilomatrixomas are very rare. These are connected with genetic syndromes, especially Steinert myotonic dystrophy which may occur some time after the appearance of the pilomatrixomas. Therefore these require follow-up. A correct identification in primary care is essential, as well as referral to a dermatology specialist, since treatment involves their removal and the ruling out and follow-up of possible associated syndromes. There are case reports of malignant pilomatrixomas (pilomatrix carcinoma). We present a case of multiple pilomatrixomas seen in primary care, which reviews the pathology and considers associated syndromes. Although accurate diagnosis is histological and treatment is surgical, the family doctor is the first physician who cares for the patient. Thus, their correct diagnostic orientation based on clinical examination, correlation and referral can speed up the process and prevent the possible complications of associated syndromes


Assuntos
Humanos , Feminino , Criança , Pilomatrixoma/patologia , Folículo Piloso/patologia , Neoplasias Cutâneas/patologia , Predisposição Genética para Doença/genética , Pilomatrixoma/epidemiologia , Neoplasias Cutâneas/cirurgia , Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Diagnóstico Diferencial , Testes Genéticos/métodos
20.
Arch Dermatol Res ; 311(10): 815-824, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31511972

RESUMO

Androgenetic alopecia (AGA) is a progressive dermatological disorder of frontal and vertex scalp hair loss leading to baldness in men. This study aimed to identify candidate genes involved in AGA through an in silico search strategy. The gene expression profile GS36169, which contains microarray gene expression data from bald frontal and haired occipital scalps of five men with AGA, was downloaded from the Gene Expression Omnibus (GEO) database. The differential gene expression analysis for all five subjects was carried out separately by PUMA package in R and identified 32 differentially expressed genes (DEGs) common to all five subjects. Gene ontology (GO) biological process and pathway- enrichment analyses of the DEGs were conducted separately for the up-regulated and down-regulated genes. ReactomeFIViz app was utilized to construct the protein functional interaction network for the DEGs. Through GO biological process and pathway analysis on the clusters of the Reactome FI network, we found that the down-regulated DEGs participate in Wnt signaling, TGF-beta signaling, and up-regulated DEGs participate in oxidative-stress- related pathways.


Assuntos
Alopecia/genética , Folículo Piloso/patologia , Mapas de Interação de Proteínas/genética , Adulto , Idoso , Alopecia/patologia , Biópsia , Biologia Computacional , Conjuntos de Dados como Assunto , Regulação para Baixo , Perfilação da Expressão Gênica/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Estresse Oxidativo/genética , Couro Cabeludo , Fator de Crescimento Transformador beta/metabolismo , Regulação para Cima , Via de Sinalização Wnt/genética
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