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1.
PLoS One ; 17(7): e0269848, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35776724

RESUMO

BACKGROUND: Recent studies have confirmed that the COVID-19 lockdown has caused massive job losses. However, the impact of this loss on food security is not well-understood. Moreover, a paucity of evidence exists regarding social protection grants' countervailing effects against such shocks. This study examined the effects of job loss (labour income loss) on child and household hungers (our two measures food insecurity) during COVID-19 pandemic in South Africa. It also ascertained whether these effect were offset by alternative social grant programs to document the protective role of the latter. DATA AND METHODS: We used South Africa's National Income Dynamics Study (NIDS) and the Coronavirus Rapid Mobile Survey (CRAM) data. These data cover a nationally representative sample of 7073 individuals. We employed a probit model to estimate the effect of job loss and receipts of various social grants on child and households' hungers. We also estimated the double-selection logit model to account for the model's uncertainty surrounding the variable selection and treatment-effects estimation using lasso (Telasso) for causal inference of our analysis. RESULTS: Our analyses showed that households exposed to a labour market shock during the pandemic experienced a significant increase in our measures of food insecurity (child and household hungers). Specifically, we found that compared with households containing employed respondents, households with respondents who lost their jobs due to COVID-19 lockdown were 5.4% more likely to report child hunger and 2.6% more likely to report household hunger in the past seven days A receipt of child support grant reduces the likelihood of reporting child hunger and household hunger by 21.7%and 16.9% respectively among these households. A receipt of old age pension grant reduces the likelihood of reporting household hunger by 24% with no significant effect on child hunger. CONCLUSION: The COVID-19 lockdown resulted in unprecedent job losses with significant implications for food insecurity. Job loss due to COVID-19 lockdown significantly increased food insecurity in South Africa. Receipts of social grants effectively offset this adverse effect. The protective effect of the social grant is heterogenous across its alternative programs (child support grant and old age pension grant) and food insecurity, suggesting the differences in the size of transfers and motivations for sending these transfers.


Assuntos
COVID-19 , Fome , COVID-19/epidemiologia , COVID-19/prevenção & controle , Criança , Controle de Doenças Transmissíveis , Abastecimento de Alimentos , Humanos , Pandemias/prevenção & controle , Política Pública , África do Sul/epidemiologia
2.
Isr Med Assoc J ; 24(7): 429-432, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35819207

RESUMO

BACKGROUND: Dr. Joseph Weill was a French Jewish doctor who made significant contributions to the knowledge of hunger disease in the refugee camps in southern France during World War II. He was involved with the clandestine network of escape routes for Jewish children from Nazi-occupied France to Switzerland. Take home messages • During the Holocaust, in the ghettoes and death camps, a few research projects, mainly on hunger and infectious diseases, were performed by Jewish physicians and scientists • Jewish and non-Jewish prisoners were incarcerated within the notorious system of internment camps in southern France • Dr. Joseph Weill (1902-1988), a French Jewish physician and a distinguished member of the Résistance managed to enter the internment camps and medically assist the inmates in addition to performing systematic research and follow-up of those who presented with hunger disease.


Assuntos
Campos de Concentração , Holocausto , Criança , Campos de Concentração/história , História do Século XX , Holocausto/história , Humanos , Fome , Judeus/história , Masculino , II Guerra Mundial
3.
BMJ Open ; 12(7): e060716, 2022 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-35803620

RESUMO

OBJECTIVE: A gap between clinical practice and evidence is common. The present multicentre study was designed to explore the actual postoperative fasting practice, including the instructed fasting time from the ward staff and the actual postoperative fasting time. DESIGN: Multicentre survey. SETTING: Four tertiary hospitals in Shenzhen City, China. PARTICIPANTS: A total of 988 patients completed a survey on instructed and actual postoperative fasting. OUTCOMES: All patients received postoperative instructed fasting time from the ward staff. The median instructed fasting time for fluids from ward staff was 6 hours (IQR, 4-6 hours), and the median instructed fasting time for solid food was also 6 hours (IQR 5-6 hours) after surgery. The actual postoperative fasting time, including fluid and solid food intake, was significantly longer than the time recommended by the ward staff (both p<0.001). RESULTS: The median time to postoperative first flatus (FFL) was 16.5 hours (IQR 8-25.5 hours), and the median time to postoperative first faeces (FFE) was 41 hours (IQR 25-57 hours). The fasting time was significantly shorter than the time to FFL and the time to FFE, regardless of surgery type or anaesthesia type (all p<0.001). Postoperative nausea and vomiting (PONV) occurred in 23.6% of patients. After surgery, 58.70% of patients reported thirst, and 47.47% reported hunger. No ileus occurred. CONCLUSION: Approximately half of the patients reported thirst and hunger postoperatively. Patients initiated oral intake earlier than the time to FFL or FFE without increasing serious complications. This study may support the rationale for interventions targeting postoperative oral intake time in future studies.


Assuntos
Jejum , Sede , Humanos , Fome , Período Pós-Operatório , Fatores de Tempo
4.
Nutrients ; 14(15)2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35893925

RESUMO

(1) Background: Excess weight in the form of adiposity plays a key role in the pathogenesis of cardiometabolic diseases. Lifestyle modifications that incorporate continuous energy restriction (CER) are effective at inducing weight loss and reductions in adiposity; however, prescribing daily CER results in poor long-term adherence. Over the past decade, intermittent fasting (IF) has emerged as a promising alternative to CER that may promote increased compliance and/or improvements in cardiometabolic health parameters independent of weight loss. (2) Methods: This paper presents a secondary analysis of data from a 12-week intervention investigating the effects of a twice-weekly fast (5:2 IF; IFT group) and CER (CERT group) when combined with resistance exercise in 34 healthy participants (17 males and 17 females, mean BMI: 27.0 kg/m2, mean age: 23.9 years). Specifically, changes in cardiometabolic blood markers and ratings of hunger, mood, energy and compliance within and between groups were analysed. Dietary prescriptions were hypoenergetic and matched for energy and protein intake. (3) Results: Both dietary groups experienced reductions in total cholesterol (TC; mean reduction, 7.8%; p < 0.001), low-density lipoprotein cholesterol (LDL-C; mean reduction, 11.1%; p < 0.001) and high-density lipoprotein cholesterol (mean reduction 2.6%, p = 0.049) over the 12 weeks. Reductions in TC and LDL-C were greater in the IFT group after adjustment for baseline levels and change in weight. No significant changes in markers of glucose regulation were observed. Both groups maintained high levels of dietary compliance (~80%) and reported low levels of hunger over the course of the intervention period. (4) Conclusions: Secondary data analysis revealed that when combined with resistance training, both dietary patterns improved blood lipids, with greater reductions observed in the IFT group. High levels of compliance and low reported levels of hunger throughout the intervention period suggest both diets are well tolerated in the short-to-medium term.


Assuntos
Doenças Cardiovasculares , Jejum , Adulto , Biomarcadores , Restrição Calórica/métodos , LDL-Colesterol , Dieta , Feminino , Humanos , Fome , Masculino , Obesidade , Redução de Peso/fisiologia , Adulto Jovem
5.
PLoS One ; 17(7): e0269629, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35793289

RESUMO

The colloquial term "hangry" refers to the notion that people become angry when hungry, but very little research has directly determined the extent to which the relationship between hunger and negative emotions is robust. Here, we examined associations between everyday experiences of hunger and negative emotions using an experience sampling method. Sixty-four participants from Central Europe completed a 21-day experience sampling phase in which they reported their hunger, anger, irritability, pleasure, and arousal at five time-points each day (total = 9,142 responses). Results indicated that greater levels of self-reported hunger were associated with greater feelings of anger and irritability, and with lower pleasure. These findings remained significant after accounting for participant sex, age, body mass index, dietary behaviours, and trait anger. In contrast, associations with arousal were not significant. These results provide evidence that everyday levels of hunger are associated with negative emotionality and supports the notion of being "hangry".


Assuntos
Avaliação Momentânea Ecológica , Fome , Ira/fisiologia , Nível de Alerta , Humanos , Humor Irritável
6.
Health Psychol ; 41(8): 559-565, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35849381

RESUMO

BACKGROUND: Compared to the effects of stress on hunger, the temporal effect of hunger on stress levels is less understood, especially in the context of everyday lives of vulnerable populations with unstable access to food. OBJECTIVE: Our objective was to examine the effects of food insecurity and momentary hunger on momentary stress and stress variability in a sample of currently and formerly homeless young adults. METHOD: We used a 7-day ecological momentary assessment study querying affect, hunger, and risky behaviors. A mixed-effects location scale model was used to examine the effects of hunger on mean levels and within- and between-subjects variability of stress with 100 currently homeless and 69 formerly homeless young adults ages 18-29 in Los Angeles County, California. RESULTS: When individuals experienced greater-than-average hunger, they then experienced greater stress variability at the next prompt, showing the impact of hunger on stress at the momentary level. Those with higher average levels of stress, regardless of hunger, became substantially more stressed when becoming hungry compared to their generally less stressed counterparts. CONCLUSIONS: The study shows the extent to which food insecurity results in erratic stress among vulnerable populations and how high levels of hunger may lead to a more inconsistent stress response. Findings reinforce the need for more mental health services and food programs for young adults who have experienced homelessness. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Assuntos
Insegurança Alimentar , Pessoas em Situação de Rua , Fome , Estresse Psicológico , Adolescente , Adulto , California/epidemiologia , Pessoas em Situação de Rua/psicologia , Pessoas em Situação de Rua/estatística & dados numéricos , Humanos , Estresse Psicológico/epidemiologia , Adulto Jovem
7.
Lit Med ; 40(1): 29-37, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35848293
8.
Elife ; 112022 07 06.
Artigo em Inglês | MEDLINE | ID: mdl-35791902

RESUMO

Taste detection and hunger state dynamically regulate the decision to initiate feeding. To study how context-appropriate feeding decisions are generated, we combined synaptic resolution circuit reconstruction with targeted genetic access to specific neurons to elucidate a gustatory sensorimotor circuit for feeding initiation in adult Drosophila melanogaster. This circuit connects gustatory sensory neurons to proboscis motor neurons through three intermediate layers. Most neurons in this pathway are necessary and sufficient for proboscis extension, a feeding initiation behavior, and respond selectively to sugar taste detection. Pathway activity is amplified by hunger signals that act at select second-order neurons to promote feeding initiation in food-deprived animals. In contrast, the feeding initiation circuit is inhibited by a bitter taste pathway that impinges on premotor neurons, illuminating a local motif that weighs sugar and bitter taste detection to adjust the behavioral outcomes. Together, these studies reveal central mechanisms for the integration of external taste detection and internal nutritive state to flexibly execute a critical feeding decision.


Assuntos
Proteínas de Drosophila , Paladar , Animais , Proteínas de Drosophila/metabolismo , Drosophila melanogaster/fisiologia , Comportamento Alimentar/fisiologia , Fome , Células Receptoras Sensoriais/fisiologia , Açúcares , Paladar/fisiologia
10.
Lit Med ; 40(1): 147-166, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35848299

RESUMO

Bram Stoker's Dracula, Sheridan Le Fanu's "Carmilla," and Anne Rice's Vampire Chronicles all paint a picture of primeval hunger. But the satiation of this hunger sustains an undead, monstrous existence. Essentially an animated corpse, the vampire embodies what Julia Kristeva has described de facto as waste. The image of the vampire perverts everything that is sacred: signficantly, it reverses the ritual of the Eucharist. Yet in doing so, it fosters an uncanny exploration of theological hunger at the heart of bodily waste. Three different models of vampirism show us how Stoker, Le Fanu, and Rice play with the concept of vital hunger at the heart of waste. At times a monstered mother, at times an uncanny lover, the vampire always feeds, and in feeding spreads waste. This essay asks: how does literary vampirism make use of waste to explore theological anxieties?


Assuntos
Medicina na Literatura , Humanos , Fome
11.
Biol Sex Differ ; 13(1): 25, 2022 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-35659737

RESUMO

BACKGROUND: Sex-based differences in appetite ratings have been observed previously. Ghrelin is the only known orexigenic peptide hormone. Sex differences in postprandial ghrelin responses may underlie different perceptions of hunger and satiety, but results are conflicting. We conducted a parallel study to evaluate sex differences in postprandial appetite ratings and ghrelin concentration after administration of a physiological meal among students of University of Milan. METHODS: Twenty-four healthy, normal weight volunteers (12 men and 12 women) aged 18-35 years were recruited. A balanced mixed meal meeting 40% of the estimated daily energy expenditure and providing 60% of calories from carbohydrates, 25% from lipids and 15% from protein was administrated. Sex differences in appetite ratings (satiety, hunger, fullness and desire to eat) and magnitude of ghrelin suppression during postprandial period (up to 180 min) were determined. RESULTS: In the fasting state, men and women did not differ in appetite ratings and ghrelin concentrations. After feeding, women tended to reach peak of satiety earlier than men, who in turn reached the nadir of hunger later than women (median: 30 min, interquartile range (IQR): 1; 120 vs. 1 min, IQR 1; 1, p = 0.007). Ghrelin suppression was greater in women (median decremental AUC - 95, IQR - 122; - 66) than in men (median decremental AUC - 47, IQR - 87; - 31, p = 0.041). CONCLUSIONS: These findings suggest sex differences in the postprandial appetite regulation that might be important for nutritional strategy to prevent and treat obesity and eating disorders.


Assuntos
Apetite , Grelina , Feminino , Peptídeo 1 Semelhante ao Glucagon , Humanos , Fome , Masculino , Período Pós-Prandial , Adulto Jovem
12.
Front Public Health ; 10: 756964, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35692350

RESUMO

In 2014, a group of undocumented migrants started a hunger strike in Brussels. The medical monitoring was mainly done by young, committed health professionals with no prior experience of medical monitoring of people on hunger strike. Following the hunger strike, two focus groups were organized to assess the experiences of the health professionals during the medical monitoring of the hunger strike. Their main motivation for assisting was wanting to help the people on hunger strike but they were also curious about the living conditions among undocumented migrants and the reasons behind starting the strike. They were puzzled by the paradox of hunger strikers putting their life at risk in order to get a better life and obtain a residence permit. They felt conflicted about their own role as a caregiver: they did not know how to deal with patients who did not comply with medical advice, they struggled to build a relationship of mutual trust and feared that they would end up being instrumentalized by the hunger strikers or their environment. Afterwards, some of the health professionals were deeply touched by the experience and there were reports of symptoms of secondary traumatic stress such as re-experiencing and avoidance. During the focus group's discussions, the respondents made suggestions on how to improve the medical monitoring in the event of any future hunger strikes.


Assuntos
Jejum , Migrantes , Pessoal de Saúde , Humanos , Fome , Confiança
13.
Cien Saude Colet ; 27(7): 2895-2909, 2022 Jul.
Artigo em Português, Inglês | MEDLINE | ID: mdl-35730855

RESUMO

The aim of this study was to identify social determinants of health associated with the experience of hunger among school-age adolescents in Brazil. We conducted a cross-sectional study with a sample of 16,526 adolescents using data from the 2015 National School-based Student Health Survey. Experience of hunger was determined based on the answer to the question "In the last 30 days, how often have you been hungry because there wasn't enough food at home?" The social determinants of health were analyzed using Poisson regression with robust variance. The prevalence of the experience of hunger was 22.8% (95%CI: 21.9-23.7). The experience of hunger was directly associated with being male (PR = 1.12; 95%CI: 1.07-1.16); not being overweight (PR = 1.08; 95%CI: 1.04-1.13 ); irregular consumption of beans (PR = 1.20; 95%CI: 1.13-1.26), vegetables (PR=1.16; 95%CI: 1.09-1.22) and fruit (PR = 1.19; 95%CI: 1.13-1.24); body dissatisfaction (PR = 1.26; 95%CI: 1.18-1.35); and not regularly eating lunch or dinner with parents or guardians (PR = 1.41; 95%CI: 1.32-1.52). An inverse association was found between the experience of hunger and maternal education level and living in the Mid-West, Southeast and South. The findings show that the experience of hunger among Brazilian adolescents coexists with risky eating behaviors, body dissatisfaction, and social inequality.


Objetivou-se identificar determinantes sociais em saúde associados à vivência da fome entre adolescentes escolares brasileiros. Foi realizado um estudo transversal com microdados de 16.526 adolescentes da Pesquisa Nacional de Saúde do Escolar 2015. A vivência da fome foi estimada considerando a frequência com que o adolescente havia ficado com fome por não ter comida suficiente em casa no mês anterior à pesquisa. Para a análise dos determinantes sociais em saúde foi realizada Regressão de Poisson com variância robusta. Verificou-se, no Brasil, que a vivência da fome foi de 22,8% (IC95%: 21,9-23,7) entre adolescentes. Essa associou-se diretamente ao sexo masculino (RP=1,12; IC95%: 1,07-1,16), a não ter excesso de peso (RP=1,08; IC95%: 1,04-1,13), ao consumo irregular de feijão (RP=1,20; IC95%: 1,13-1,26), de legumes e verduras (RP=1,16; IC95%: 1,09-1,22) e de frutas (RP=1,19; IC95%: 1,13-1,24), à insatisfação corporal (RP=1,26; IC95%: 1,18-1,35) e ao consumo irregular de almoço ou jantar com os responsáveis (RP=1,41; IC95%: 1,32-1,52); e inversamente ao gradiente de escolaridade materna, e às macrorregiões do complexo Centro-Sul. Os resultados indicam a coexistência da fome, comportamentos alimentares de risco nutricional, insatisfação corporal e condições de iniquidade social entre adolescentes brasileiros.


Assuntos
Fome , Determinantes Sociais da Saúde , Adolescente , Brasil/epidemiologia , Estudos Transversais , Comportamento Alimentar , Feminino , Humanos , Masculino
14.
Lancet Planet Health ; 6(6): e455, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35709801

Assuntos
Fome
15.
Addict Behav ; 133: 107381, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35659692

RESUMO

A disproportionate amount of research on impulsivity has focused on trait-related aspects rather than state fluctuations. As a result, the relationship between state impulsivity and moment-to-moment behaviour is unclear. Impulsivity is assumed to negatively affect self-control, but an alternative explanation, yet to be tested, could be that changes in state impulsivity and its homeostatic drivers influence the intensity of urges. We tested whether state impulsivity and hunger affected behaviour through a dual-process model, affecting both the experience of various urges, and self-control, using a smartphone-based experience sampling approach. We found that state impulsivity is associated with stronger urges, but we found no evidence of an association with diminished self-control. Being hungry amplifies urges across different types of urges, and both hunger and late hours are negatively related to the likelihood of controlling urges. These findings imply that the influence of hunger is not limited to the food domain, and provide new insight into the role of state impulsivity in daily life.


Assuntos
Comportamento Impulsivo , Autocontrole , Avaliação Momentânea Ecológica , Humanos , Fome
16.
PLoS One ; 17(6): e0269891, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35704632

RESUMO

While global food trade has allowed countries to buffer against domestic food production shortfalls and gain access to larger markets, engaging in trade has also opened economies up to shocks and increased extraction of food resources. With this research, we analyze how the global grain network influences country-level nourishment, while controlling for per capita land and food production. First, we model the trade network structure of the global wheat supply chain to measure the centrality or positionality of countries. We use spatial regression analysis to assess the impact of trade networks, volume, purchasing power, production capacity and geography on undernourishment. We find that the six countries most central to the global grain trade by betweenness and eigenvector centralities account for more than half of all wheat exports globally by volume. The centrality of these countries as opposed to volume of wheat produced or traded, determines their influence in the wheat supply chain network. The parametric component of our analysis confirms that trade, and centrality have significant implications for national levels of nourishment. Our findings suggest that for countries with low purchasing power, increasing centrality allows improvements in nourishment levels but for countries with very high purchasing power, increasing centrality can increase hunger outcomes. To counteract perturbations and shortfalls such as those being experienced currently in the globalized food system, local and regional governments may consider refocusing on regional and local based food systems.


Assuntos
Fome , Triticum , Grão Comestível , Abastecimento de Alimentos
17.
Aust N Z J Public Health ; 46(4): 444-449, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35679018

RESUMO

OBJECTIVE: Food insecurity is a threat to children's development and in Australia 13.5% of households experience food insecurity. Universal school food programs, however, are not provided nationally. Teachers and not-for-profit organisations have instead mobilised to tackle hunger. The strategies used and their effects on students have limited empirical evidence. The aim of this study is to gain perspectives on the causes and consequences of children's food insecurity in schools and describe food security strategies adopted. METHOD: One hundred schools in Victoria, which participate in a not-for-profit lunch program provided by Eat Up were invited to take part in the study. Fifteen staff (including school principals and welfare officers) from 15 schools were recruited for semi-structured interviews.  Results: There was evidence that children experience adverse quantity, quality, social and psychological impacts of food insecurity whilst in school settings. Participants described employing multiple strategies including free meals (e.g. lunch, breakfast) and food (e.g. parcels) for food insecure students and their families. Conclusions and implications for public health: In our sample, multiple strategies were being employed by schools to reduce food insecurity, but there remains unmet need for additional wide-scale initiatives to address this critical issue and its causes and consequences.


Assuntos
Fome , Instituições Acadêmicas , Criança , Insegurança Alimentar , Abastecimento de Alimentos , Humanos , Almoço , Vitória
18.
Appetite ; 176: 106132, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-35700840

RESUMO

Intuitive eating (IE) emphasizes relying on hunger and satiety cues to guide eating, and is associated with positive mental health and health-promoting behaviors. Although parents' own eating patterns often shape those of their children, no known research has explored familial associations of IE. The purpose of this cross-sectional, population-based study was to examine IE concordance between emerging adults and their parents, and whether concordance differed across sociodemographic characteristics and weight perceptions. The analytic sample included 891 emerging adults (M age = 22.0) and their primary parent (M age = 50.4) who participated in the population-based, longitudinal EAT and F-EAT 2010-2018 studies. Parents and emerging adults were grouped into dyads based on IE concordance: (1) neither are intuitive eaters; (2) only the emerging adult is an intuitive eater; (3) only the parent is an intuitive eater; (4) both are intuitive eaters. Dyads differed across socioeconomic status (SES), race/ethnicity, and weight perceptions. Concordant dyads who ate intuitively were more likely to be at higher SES and perceive their weight as "about right" than concordant dyads who did not eat intuitively. Asian emerging adults were most likely to belong to concordant non-intuitive eater dyads. Emerging adults who shared their parent's perception their weight was "overweight" were less likely to be intuitive eaters (even if their parents were). In this sample, sociodemographic characteristics and weight perceptions were related to IE concordance among emerging adults and their parents. Lower SES might be an intergenerational barrier to IE disproportionately impacting communities of color, though longitudinal data are needed. Results also suggest rather than motivating healthful eating, perceiving one's weight as "overweight" could hinder IE. Differences across sociodemographic variables likely intersect in meaningful ways, which is an important future research direction.


Assuntos
Comportamento Alimentar , Pais , Adulto , Peso Corporal , Criança , Estudos Transversais , Ingestão de Alimentos , Comportamento Alimentar/psicologia , Humanos , Fome , Pessoa de Meia-Idade , Sobrepeso , Pais/psicologia , Adulto Jovem
19.
PLoS Genet ; 18(6): e1010219, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35675262

RESUMO

Animals detect changes in both their environment and their internal state and modify their behavior accordingly. Yet, it remains largely to be clarified how information of environment and internal state is integrated and how such integrated information modifies behavior. Well-fed C. elegans migrates to past cultivation temperature on a thermal gradient, which is disrupted when animals are starved. We recently reported that the neuronal activities synchronize between a thermosensory neuron AFD and an interneuron AIY, which is directly downstream of AFD, in well-fed animals, while this synchrony is disrupted in starved animals. However, it remained to be determined whether the disruption of the synchrony is derived from modulation of the transmitter release from AFD or from the modification of reception or signal transduction in AIY. By performing forward genetics on a transition of thermotaxis behavior along starvation, we revealed that OLA-1, an Obg-like ATPase, functions in AFD to promote disruption of AFD-AIY synchrony and behavioral transition. Our results suggest that the information of hunger is delivered to the AFD thermosensory neuron and gates transmitter release from AFD to disrupt thermotaxis, thereby shedding light onto a mechanism for the integration of environmental and internal state to modulate behavior.


Assuntos
Proteínas de Caenorhabditis elegans , Caenorhabditis elegans , Adenosina Trifosfatases/genética , Animais , Caenorhabditis elegans/genética , Proteínas de Caenorhabditis elegans/genética , Fome , Células Receptoras Sensoriais , Temperatura
20.
Lancet ; 399(10340): 1991, 2022 05 28.
Artigo em Inglês | MEDLINE | ID: mdl-35644142

Assuntos
Fome , Humanos
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