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1.
Rev Assoc Med Bras (1992) ; 66(9): 1235-1240, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33027451

RESUMO

INTRODUCTION: Sarcopenia is characterized by the involuntary loss of lean body mass associated with a progressive reduction of muscle strength. OBJECTIVE: To determine the prevalence of sarcopenia in kidney transplant recipients and its association with the determining factors that control muscle homeostasis. METHODS: We evaluated renal transplant recipients undergoing follow-up at the University Hospital of the Federal University of Maranhão from June 2017 to July 2018 and who met the inclusion criteria. Sarcopenia was defined according to the European criteria. The skeletal muscle mass index was measured by dual-energy radiological absorptiometry; the values <7,26 kg/m2 for men and <5,5 kg/m2 for women were adopted for muscle depletion. For handgrip strength, values of <30 kg for men and <20 kg for women were considered as reduced muscle strength. In both sexes, the cutoff point for walking speed was <0,8 m/s. RESULTS: We evaluated 83 renal transplant recipients with a mean age of 48.8 ± 12,1 years and predominantly males (57,8%). The prevalence of sarcopenia was 19,3%. Among individuals without sarcopenia, 17,9% had a decrease in handgrip strength and 40,3% has altered gait speed. DISCUSSION: Individuals submitted to renal transplant may develop sarcopenia while still young and already present altered muscle function and strength even before the depletion of lean body mass. CONCLUSION: Early diagnosis may allow the prevention of sarcopenia and provide a better quality of life for patients.


Assuntos
Transplante de Rim , Sarcopenia , Adulto , Feminino , Força da Mão , Homeostase , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Qualidade de Vida
2.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2151-2154, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018432

RESUMO

Cervical spinal cord injury (cSCI) can cause paralysis and impair hand function. Existing assessments in clinical settings do not reflect an individual's performance in their daily environment. Videos from wearable cameras (egocentric video) provide a novel avenue to analyze hand function in non-clinical settings. Due to the large amounts of video data generated by this approach, automated analysis methods are necessary. We propose to employ an unsupervised learning process to produce a summary of the grasping strategies used in an egocentric video. To this end, an approach was developed consisting of hand detection, pose estimation, and clustering algorithms. The performance of the method was examined with external evaluation indicators and internal evaluation indicators for an uninjured and injured participant, respectively. The results demonstrated that a Gaussian mixture model obtained the highest accuracy in terms of the maximum match, 0.63, and the Rand index, 0.26, for the uninjured participant, and a silhouette score of 0.13 for the injured participant.


Assuntos
Mãos , Traumatismos da Medula Espinal , Análise por Conglomerados , Força da Mão , Humanos , Paralisia
3.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3015-3018, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018640

RESUMO

Electroencephalogram (EEG) based braincomputer interface (BCI) systems are useful tools for clinical purposes like neural prostheses. In this study, we collected EEG signals related to grasp motions. Five healthy subjects participated in this experiment. They executed and imagined five sustained-grasp actions. We proposed a novel data augmentation method that increases the amount of training data using labels obtained from electromyogram (EMG) signals analysis. For implementation, we recorded EEG and EMG simultaneously. The data augmentation over the original EEG data concluded higher classification accuracy than other competitors. As a result, we obtained the average classification accuracy of 52.49(±8.74)% for motor execution (ME) and 40.36(±3.39)% for motor imagery (MI). These are 9.30% and 6.19% higher, respectively than the result of the comparable methods. Moreover, the proposed method could minimize the need for the calibration session, which reduces the practicality of most BCIs. This result is encouraging, and the proposed method could potentially be used in future applications such as a BCI-driven robot control for handling various daily use objects.


Assuntos
Interfaces Cérebro-Computador , Eletroencefalografia , Força da Mão , Movimento (Física) , Movimento
4.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3023-3026, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018642

RESUMO

Neural oscillating patterns, or time-frequency features, predicting voluntary motor intention, can be extracted from the local field potentials (LFPs) recorded from the sub-thalamic nucleus (STN) or thalamus of human patients implanted with deep brain stimulation (DBS) electrodes for the treatment of movement disorders. This paper investigates the optimization of signal conditioning processes using deep learning to augment time-frequency feature extraction from LFP signals, with the aim of improving the performance of real-time decoding of voluntary motor states. A brain-computer interface (BCI) pipeline capable of continuously classifying discrete pinch grip states from LFPs was designed in Pytorch, a deep learning framework. The pipeline was implemented offline on LFPs recorded from 5 different patients bilaterally implanted with DBS electrodes. Optimizing channel combination in different frequency bands and frequency domain feature extraction demonstrated improved classification accuracy of pinch grip detection and laterality of the pinch (either pinch of the left hand or pinch of the right hand). Overall, the optimized BCI pipeline achieved a maximal average classification accuracy of 79.67±10.02% when detecting all pinches and 67.06±10.14% when considering the laterality of the pinch.


Assuntos
Transtornos dos Movimentos , Força da Mão , Humanos
5.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3269-3272, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018702

RESUMO

Muscle synergy is a fundamental mechanism of motor control. Despite a number of studies focusing on muscle synergy during power grip and pinch at high-level force, relatively less is known about the functional interactions between muscles within low-level force production during precision pinch. Traditional analytical tools such as nonnegative matrix factorization or principal component analysis have limitations in processing nonlinear dynamic electromyographic signals and have confined sensitivity particularly for the low-level force production. In this study, we developed a novel method - multiplex muscle networks, to investigate the dynamical coordination of muscle activities at low-level force production during precision pinch. The multiplex muscle network was constructed based on multiplex limited penetrable horizontal visibility graph (MLPHVG). Seven forearm and hand muscles, including brachioradialis (BR), flexor carpi ulnaris (FCU), flexor carpi radialis (FCR), flexor digitorum superficialis (FDS), extensor digitorum communis (EDC), abductor pollicis brevis (APB) and first dorsal interosseous (FDI), were examined using surface electromyography (sEMG). Eight healthy subjects were instructed to perform a visuomotor force tracking task by producing higher (10% MVC) and lower (1% MVC) precision pinch. Interlayer mutual information I, average edge overlap ω weighted clustering coefficient CW, weighted characteristic path length LW were selected as network metrics. We assessed the undirected weighted network generated from multiplex muscle network after taking the I between paired muscle network layers as edge. There are significant differences between higher and lower force level with higher I, ω, CW and lower LW at higher force level. Advanced efficiency of information processing in the regional and global perspective indicated dynamical alterations when human faces the higher force tracking task. It suggested that ω may be an important characteristic to classify different force control states with the average classification accuracy of 82.21%. These findings reveal related alterations of functional interactions between muscles involved in precision pinch. The novel method for constructing multiplex muscle network may provide insights into muscle synergies during precision pinch force control.


Assuntos
Força da Mão , Músculo Esquelético , Eletromiografia , Antebraço , Mãos , Humanos
6.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3355-3358, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018723

RESUMO

After a spinal cord injury, a person may grasp objects using a brain-computer interface (BCI) to control a robot arm. However, most BCIs do not restore somatosensory percepts that would enable someone to sense grasp force. Intracortical microstimulation (ICMS) in the somatosensory cortex can evoke tactile sensations and may therefore offer a viable solution to provide grasp force feedback. We investigated whether a bidirectional BCI could improve grasp force control over a BCI using only visual feedback. When evaluating the error of the applied force during a force matching task, we found that ICMS feedback improved overall applied grasp force accuracy.


Assuntos
Interfaces Cérebro-Computador , Retroalimentação , Força da Mão , Humanos , Córtex Somatossensorial , Tato
7.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3788-3791, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018826

RESUMO

Muscle synergistic contraction to produce force has been recognized as an important neurophysiological mechanism in neuromuscular system. Despite a range of approaches, such as nonnegative matrix factorization or principal component analysis that have been widely used, limitations still exist in analysis of dynamic coordination of multiple muscles. In addition, it is still less studied about the potential difference of muscle dynamic coordination at different force levels during grip and pinch within the same framework. With this aim, this study analyzed the dynamic coordination of multiple upper-limb muscles at low, medium and high force levels during pinch and grip with multiplex recurrence network (MRN). Twenty-four healthy subjects participated in the experiment. Subjects were instructed to grip an apparatus to match the target force as stably as they could for 10 s. Surface electromyographic (sEMG) signals were recorded from 8 upper-limb muscles and analyzed by the MRN. The interlayer mutual information (I) and the average edge overlap (ω) of MRNs were calculated to quantify muscle correlation and muscle synchronization, respectively. Results showed that I and ω values of extrinsic muscles' MRNs during grip were significantly higher than that during grip at medium and high force. Furthermore, the I and ω values of extrinsic muscle networks during grip increased with augmented force levels. No significant changes were found for the intrinsic muscles with force output levels. These findings indicate that the muscles coordination patterns between grip and pinch were different and higher co-contraction of extrinsic muscles is favorable to synergistic force production. With the force output increased, muscles' coordination was augmented in extrinsic muscles, but no change in intrinsic muscles because of independent and complicated control of fingers. This study provides an analytical tool for dynamic muscles coordination and provides insights into the mechanisms of synergistic control of muscle contractions for force production.Clinical Relevance-This study provides a novel analytical tool for muscle coordination during force production, which may facilitate the evaluation of neuromuscular function or serve as indicators for neuromuscular disorders.


Assuntos
Força da Mão , Músculo Esquelético , Eletromiografia , Dedos , Contração Muscular
8.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 4020-4023, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018881

RESUMO

Reach-to-grasp actions have been recently studied to highlight how intentions influence action planning and shapes the movement kinematics. Reach-to-grasp (RG) kinematics can reveal important information on motor planning and control in several pathologies, including neurodegenerative diseases. Current methods are mainly based on optoelectronic analysis systems, which provide accurate movement tracking but are expensive, time-consuming, and limited to constrained research-oriented space. In this study, we proposed an innovative, non-invasive, and easy-to-use ringshaped wearable system, named SensRing, able to record inertial data during the movement. To ensure accurate and precise measures, which are mandatory for clinical practice, a preliminary technical validation of the SensRing with respect to the Vicon (i.e., gold standard for motion analysis) was performed on two finger tapping exercises. Preliminary results pointed out very low discrepancies in terms of absolute errors (AbsErr) between the values of repetitions (AbsErr≤0.8), frequency (AbsErr=0.04Hz) and amplitude (AbsErr≤2.7deg) measured by the two systems, as well as high correlation between the measures obtained with the inertial and optical system. Therefore, inertial data from the SensRing were used in a "reach-to-grasp and move" protocol to calculate the performance of a group of healthy young subjects during three RG and move sequences. Particularly, subjects were instructed to reach and grasp a bottle to drink (DRINK), to place it on the table (IND) or to pass it to another partner (SOC). Results showed that SensRing could identify that, in the RG phase, different intentions determine different kinematic parameters of grasping the same object. As concerns the phase of moving, if the movement is different (drink vs IND/SOC) it's easier to find differences between the tasks, but also when the action is the same but with different social intent (IND vs SOC) SensRing found a significant difference.


Assuntos
Desempenho Psicomotor , Dispositivos Eletrônicos Vestíveis , Objetivos , Força da Mão , Humanos , Movimento
9.
Med Probl Perform Art ; 35(3): 130-137, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32870964

RESUMO

AIMS: The musician's hand represents a complex system, which requires important motor skills. Although several studies have already investigated rehabilitation outcomes and techniques in musicians after hand lesions, none have been addressed specifically to objectively quantifiable functional parameters. The purpose of our study was to study hand functionality in violinists in order to provide foundations on which to establish and develop more appropriate rehabilitation protocols. STUDY DESIGN: An observational cross-sectional cohort study consisting of 34 subjects, including 23 students and 11 professional violinists who were either studying or working at a conservatory. Results were compared to a data set of a non-musician control group. METHODS: Nine-hole peg test and hand test system (HTS) were used to perform the study. A hand-held dynamometer was used to measure hand grip and tripod pinch maximal isometric voluntary contraction of both hands. RESULTS: Hand strength did not significantly differ on either side between professional and student violinists. A significant difference was seen when comparing violinists as a whole versus the non-musician control group. HTS highlighted significant differences in dexterity. CONCLUSION: Violinists develop better overall motor performances of the left hand, and their performance is better than normal "non-musician" controls. Dexterity and precision of execution positively correlate to years of practice. We conclude that rehabilitation of a violinist's hand should be aimed at enhancing motor performance of the left hand and should be focused to maximize dexterity of both hands.


Assuntos
Força da Mão , Destreza Motora , Música , Estudos Transversais , Mãos , Humanos , Modalidades de Fisioterapia , Estudantes
10.
Medicine (Baltimore) ; 99(37): e21845, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32925721

RESUMO

RATIONALE: Myotonic dystrophy type 1 (DM1) is an autosomal-dominant disorder associated with a short life expectancy and various symptoms, including grip myotonia. Even though grip myotonia decreases quality of life, activities of daily living (ADLs), and work performance, very few interventions provide symptomatic relief. PATIENT CONCERNS: In this case report, we present a patient with DM1 and gradually worsening grip myotonia. A 35-year-old woman developed grip myotonia at age 27. She had no underlying diseases or family history of relevant conditions, including DM1. She was unresponsive to medication for several years. DIAGNOSIS: Her symptoms gradually worsened, and she was finally diagnosed with DM1 via genetic, neurologic, and laboratory testing in a tertiary hospital at age 32. She tried several medication therapies; however, she stopped medication at age 34 due a perceived poor response and several adverse events. INTERVENTION: At the age of 35, she underwent 29 sessions (10 minutes per session) of electroacupuncture therapy on TE9 acupuncture point with 120 Hz electrical stimulation over 3 months. OUTCOMES: After 3 months, relaxation time after maximal voluntary isometric contraction decreased from 59 to 2 seconds with treatment. Her Michigan Hand Outcomes Questionnaire score improved (total score, 66.6-75.9; ADL sub-score, 59.7-73.6; function sub-score, 70-90; satisfaction sub-score, 75-91.7). Her Measure Yourself Medical Outcome Profile 2 score also improved from 4.33 to 2. There were no serious adverse events. LESSONS: Electroacupuncture is a potential treatment modality and produced an immediate antimyotonic effect, and cumulative long-term treatment effect, in a patient with DM1 and grip myotonia. Other notable treatment outcomes included improving relaxation time, hand function, ADLs, and overall satisfaction. Electroacupuncture is a potential treatment modality for patients with DM1 and grip myotonia. Further prospective clinical studies are warranted to confirm this hypothesis.


Assuntos
Eletroacupuntura/métodos , Distrofia Miotônica/terapia , Adulto , Feminino , Força da Mão/fisiologia , Humanos , Distrofia Miotônica/fisiopatologia , Resultado do Tratamento
11.
Medicine (Baltimore) ; 99(37): e22008, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32925732

RESUMO

BACKGROUND: Acupuncture has been widely used for relieving pain associated with musculoskeletal disorders, such as lateral epicondylitis. Although the effect of acupuncture on pain has been demonstrated in previous reviews, it is still under debate. This study is aimed at evaluating the efficacy of acupuncture to treat lateral epicondylitis and establishing the evidence systematically. METHODS: Nine databases will be searched from their inception to May 2020 without language or publication status restrictions, including 3 English databases (MEDLINE, Embase, the Cochrane Central Register of Controlled Trials), 5 Korean databases (Korean Medical Database, KoreaMed, Korean Studies Information Service System, Research Information Service System, Oriental Medicine Advanced Searching Integrated System), and 1 Chinese database (China Knowledge Network Database). Only randomized controlled trials will be included. Pain intensity will be considered as the primary outcome. Secondary outcomes will include the grip strength, total effective rate, and adverse events. Two independent researchers will perform the study selection, data extraction, and quality assessment. The methodological quality of the identified studies will be assessed using the Cochrane Collaboration's risk-of-bias tool. In the meta-analysis, continuous data will be expressed as mean and 95% confidence interval, and dichotomous data will be expressed as risk ratio and 95% confidence interval. RESULTS: The results of this study will be submitted to a peer-reviewed journal for publication. CONCLUSION: The results of this study would provide the evidence of whether acupuncture is effective for lateral epicondylitis. REGISTRATION NUMBER: PROSPERO CRD42020186824.


Assuntos
Terapia por Acupuntura , Metanálise como Assunto , Revisões Sistemáticas como Assunto , Cotovelo de Tenista/terapia , Terapia por Acupuntura/efeitos adversos , Força da Mão , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Cotovelo de Tenista/fisiopatologia , Resultado do Tratamento
12.
Am J Phys Med Rehabil ; 99(10): 902-908, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32941253

RESUMO

OBJECTIVE: The aim of the study was to explore an individualized sonographic muscle thickness ratio and its cutoff values in the diagnosis of sarcopenia. DESIGN: A total of 326 community-dwelling adults were included in this cross-sectional study. Total skeletal muscle mass was evaluated by bioelectrical impedance analysis, and nine-site muscle thickness measurements using ultrasound. Isometric handgrip and knee extension strengths were assessed. Physical performance was evaluated by usual Gait Speed, Chair Stand Test, and Timed Up and Go Test. RESULTS: Because the anterior thigh muscle thickness was the most significantly decreasing measurement with aging and the most significantly related value with body mass and height; sonographic thigh adjustment ratio was calculated by dividing it with body mass index. Using the two standard deviation values of our healthy young adults, sonographic thigh adjustment ratio cutoff values were found as 1.4 and 1.0 for male and female subjects, respectively. Sonographic thigh adjustment ratio values were negatively correlated with Chair Stand Test and Timed Up and Go Test in both sexes (all P < 0.05) and positively correlated with gait speed in female subjects and knee extension strength in male subjects (both P < 0.05). CONCLUSIONS: Our results imply that regional (rather than total) muscle mass measurements should be taken into consideration for the diagnosis of sarcopenia.


Assuntos
Sarcopenia/diagnóstico por imagem , Coxa da Perna/diagnóstico por imagem , Ultrassonografia/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Diagnóstico Diferencial , Impedância Elétrica , Feminino , Força da Mão/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia
13.
Geriatr Gerontol Int ; 20(10): 980-987, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32886834

RESUMO

AIMS: Sarcopenia is a serious problem because of its poor prognosis. Growth differentiation factor 15 (GDF15) is associated with mitochondrial dysfunction, inflammation, insulin resistance and oxidative stress, which may play crucial roles for the development of sarcopenia. We aimed to examine whether serum GDF15 level is associated with muscle mass, strength and lower extremity function in older patients with cardiometabolic disease. METHODS: Serum GDF15 levels were measured in 257 patients with cardiometabolic diseases (including 133 patients with diabetes) who had visited the frailty clinic, using a latex turbidimetric immunoassay. Appendicular skeletal muscle index, handgrip strength, timed-up-and-go test and gait speed were evaluated. Power, speed, balance and total scores based on the sit-to-stand test were calculated to assess lower extremity function. RESULTS: The highest tertile of serum GDF15 was independently associated with low handgrip strength, low gait speed, long timed-up-and-go time and scores of lower extremity function but not an appendicular skeletal muscle index in multiple logistic regression analyses after adjustment for covariates. Patients in the highest tertile of GDF15 were at the risk of having three to nine times lower grip strength, three times lower gait speed, five to six times lower mobility and five to 11 times reduction in lower extremity function as compared with those in the lowest GDF15 tertile dependent on the models. CONCLUSIONS: Elevated serum GDF15 level was independently associated with low muscle strength and lower extremity function in older patients with cardiometabolic disease. Serum GDF15 could be one of the biomarkers for muscle weakness and low physical performance. Geriatr Gerontol Int 2020; 20: 980-987.


Assuntos
Doenças Cardiovasculares/sangue , Diabetes Mellitus/sangue , Fator 15 de Diferenciação de Crescimento/sangue , Extremidade Inferior/fisiopatologia , Força Muscular/fisiologia , Sarcopenia/sangue , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Doenças Cardiovasculares/fisiopatologia , Diabetes Mellitus/fisiopatologia , Feminino , Fragilidade , Força da Mão , Humanos , Masculino , Músculo Esquelético/fisiopatologia , Sarcopenia/fisiopatologia , Estudos de Tempo e Movimento , Velocidade de Caminhada/fisiologia
14.
Int J Rehabil Res ; 43(3): 280-284, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32769585

RESUMO

The objective of this study was to investigate the effect of serious games on hand muscle strength and functionality in a series of cases with ulnar nerve damage. Two patients were included in this 16-week intervention study using biofeedback. Electromyography electrodes and dynamometers were used in treatment. Functionality was assessed by Rosen and Lundborg score, Disabilities of the arm, shoulder and hand (DASH) questionnaire and International Classification of Functioning, Disability and Health (ICF). Grip and pinch strength were assessed by dynamometers. Results revealed an increase in sensory domain of Rosen and Lundborg score of the two patients. Patients increased values from the DASH questionnaire; however, they got better results with ICF. Grip strength of the two patients increased; pinch strength varied between patients; key pinch had the best results. Serious games can be effective to enhance hand strength and improve functionality in patients with ulnar nerve damage.


Assuntos
Nervo Ulnar , Adulto , Feminino , Força da Mão/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Extremidade Superior , Jogos de Vídeo
15.
Medicine (Baltimore) ; 99(30): e21189, 2020 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-32791694

RESUMO

BACKGROUND: The aim of the present study was to investigate the effectiveness of Extracorporeal Shock Wave (ECSW) in the treatment of lateral epicondylitis (LE) of humerus. HYPOTHESIS: ECSW therapy in people with LE effectively reduces the pain and gains functional rehabilitation. MATERIALS/METHODS: Databases of PubMed, EMBASE, Web of Science and the Cochrane Library from inception to April 2020 was searched to identify all relevant RCTs comparing ECSW therapy with any other conservative treatment, including injection and local anesthetic versus placebo or control in patients aged 18 with LE. The primary outcome is the mean overall pain score at 12 weeks after treatment. Another secondary outcome mainly included Thomsen test, 50% pain reduction, grip strength and adverse effect at 12 weeks after treatment. RESULTS: Nine studies were included in the meta-analysis. Compared with the placebo group, ECSW cannot significantly reduce the pain score (mean deviation [MD] = -4.23, 95% confidence interval [CI]: -8.78 to 0.32, P = .07), but make more people acquire 50% pain reduction (MD = 1.38, 95% CI: 1.09 to 1.75, P = .008). There was no significant difference between ECSW and control in decreasing the pain score of Thomsen test (MD = -3.22, 95% CI: -14.06 to 7.62, P = .56). ECSW was more effective in Grip strength as compared with control at 12 weeks-3 months (MD = 3.52, 95% CI: 2.43 to 4.60, P < .00001) CONCLUSIONS:: Results suggested that ECSW cannot effectively reduce the mean overall pain, but it showed more people acquire 50% pain reduction and might be a better option for the treatment of LE. Because of study limitations, additional high level of evidence, more rigorously designed large-samples and high-quality randomized controlled trials are needed to guide clinical practice.


Assuntos
Tratamento por Ondas de Choque Extracorpóreas , Cotovelo de Tenista/terapia , Tratamento por Ondas de Choque Extracorpóreas/efeitos adversos , Força da Mão , Humanos , Medição da Dor , Ensaios Clínicos Controlados Aleatórios como Assunto
16.
Ideggyogy Sz ; 73(7-08): 249-252, 2020 Jul 30.
Artigo em Húngaro | MEDLINE | ID: mdl-32750241

RESUMO

Objective - Conflicting theoretical models exist regarding the mechanism related to the ability of the Jendrassik maneuver to reinforce reflex parameters. Our objective was to investigate if vigorous handgrip would induce changes in recurrent inhibition of soleus motoneurons. Method - Soleus H reflex was evoked by stimulating the tibial nerve at rest and during bilateral vigorous handgrip, alternating single (H1) and paired stimulation (H2). At paired stimulation we used interstimulus intervals of 10, 15, 20 and 25 ms and supramaximal test stimulus. H1- and H2-wave amplitudes were expressed as percentage of maximal M-wave amplitude. Conditioned H2 wave maximal (H2max) and minimal (H2) amplitudes evoked at rest and expressed as a percentage of the unconditioned H1max amplitude were compared with the corresponding values obtained during handgrip by means of paired Student test and Bonferroni correction. Subjects - At the study participated 28 healthy volunteers. Results - The H1max/Mmax × 100 values obtained during handgrip (37.5±10.1) were significantly higher than those obtained at rest (27.1±7.4). The H2max/H1max × 100-va-lues obtained at paired stimulation were significantly higher during handgrip than at rest, while no significant diffe-rence was found between the H2/H1max × 100-values obtained during handgrip and at rest respectively. Discussion - The H2max/H1max is determined by both the excitability of the motoneurons and the recurrent inhibition elicited by the conditioning stimulus, while H2/H1max indicates only the level of recurrent inhibition. According to our results the Renshaw cells retain their inhibitory effect on the soleus alpha motoneurons during remote muscle contraction. Conclusion - Soleus H reflex enhancement during Jendrassik maneuver is not due to decrease of recurrent inhibition.


Assuntos
Antebraço/fisiologia , Reflexo H , Força da Mão , Contração Muscular/fisiologia , Músculo Esquelético/fisiologia , Eletromiografia , Reflexo H/fisiologia , Humanos , Músculos/inervação , Nervo Tibial/fisiologia
17.
PLoS One ; 15(8): e0237421, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32853272

RESUMO

Body image disorders in anorexia nervosa (AN) patients and recovered AN (RAN) patients have been suggested to stem from aberrant integration of sensory information. Previous research by Case et al. (2012) used the size-weight illusion (SWI) to study multisensory integration in AN. Their results showed a diminished SWI in AN patients, which they interpreted as evidence of decreased integration of visual and proprioceptive information. However, their method did not distinguish between visual and haptic size information, which was presented concurrently while making weight judgements. Therefore, the reported effect might be attributed to integrating visual, haptic size cues, or a combination of both processes with proprioceptive input. Here, we use the SWI to investigate the integration of visual and haptic object-related sensory information in a sample of AN patients (n = 30), RAN patients (n = 29) and healthy controls (HC) (n = 29). We aimed to distinguish the contribution of visual and haptic object size by including separate visual and haptic SWI conditions. In addition to explicit measures, we included grip force measurements to assess implicit expectations about object weight. We further analysed the correlation between the SWI and a visual body size estimation (VSE) task. In contrast to Case et al. (2012), we found no evidence of differential SWI experience between groups. All participants reported a stronger visual SWI compared to haptic SWI. Grip force rate (but not peak) showed evidence of motor adaptation for the larger object in the visual condition. Furthermore, there was no correlation between the VSE and SWI, indicating no relation between perceived object weight and body size estimation. These results do not support the hypothesised impairment of visual-haptic object related integration in AN.


Assuntos
Anorexia Nervosa/psicologia , Ilusões/fisiologia , Percepção de Tamanho , Percepção do Tato , Percepção Visual , Percepção de Peso , Adulto , Feminino , Força da Mão , Humanos , Masculino
18.
PLoS One ; 15(8): e0236111, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32790685

RESUMO

A relationship between chronic pain and frailty has been reported. The early detection and prevention of frailty are recommended, in part because community-dwelling older adults in a pre-frailty state may return to a healthy state. The relationship between chronic pain and pre-frailty is not known. Toward the goal of promoting a reversible return to health from pre-frailty, we investigated the relationship between chronic pain and pre-frailty among community-dwelling older adults. We assessed the frailty and chronic pain of 107 older adults who were participating in community health checks. The status of physical frailty was based on the five components described by Fried (2001): muscle weakness shown by handgrip strength, slowness of gait speed, weight loss, low physical activity, and exhaustion. Chronic pain was assessed based on pain intensity, the Pain Catastrophizing Scale (PCS), the Japanese version of the Geriatric Depression Scale-15 (GDS-15), and the Central Sensitization Inventory (CSI). The prevalence of chronic pain with pre-frailty was 40.2%. A hierarchical analysis revealed that PCS-measured helplessness (odds ratio [OR]: 0.88) and the CSI (OR: 0.87) were significant factors associated with the presence of chronic pain with pre-frailty. The prevalence of chronic pain with pre-frailty was high, and chronic pain and pre-frailty were strongly related. New intervention or prevention programs that take into account both chronic pain and pre-frailty must be created as soon as possible.


Assuntos
Catastrofização/epidemiologia , Dor Crônica/epidemiologia , Fragilidade/prevenção & controle , Vida Independente , Debilidade Muscular/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Catastrofização/psicologia , Dor Crônica/complicações , Dor Crônica/diagnóstico , Dor Crônica/psicologia , Estudos Transversais , Feminino , Idoso Fragilizado/psicologia , Idoso Fragilizado/estatística & dados numéricos , Fragilidade/diagnóstico , Fragilidade/etiologia , Avaliação Geriátrica , Força da Mão , Humanos , Japão/epidemiologia , Masculino , Pessoa de Meia-Idade , Debilidade Muscular/diagnóstico , Debilidade Muscular/etiologia , Medição da Dor , Prevalência
19.
Life Sci ; 258: 118243, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32791154

RESUMO

AIMS: Although autophagy impairment is a well-established cause of muscle atrophy and P300 has recently been identified as an important regulator of autophagy, the effects of P300 on autophagy and muscle atrophy in type 2 diabetes (T2D) remain unexplored. We aimed at characterizing the role of P300 in diabetic muscle and its underlying mechanism. MAIN METHODS: Protein levels of phosphorylated P300, total P300, acetylated histone H3, LC3, p62 and myosin heavy chain, and mRNA levels of Atrogin-1 and MuRF1 were analyzed in palmitic acid (PA)-treated myotubes and db/db mice. Autophagic flux was assessed using transmission electron microscopy, immunofluorescence and mRFP-GFP-LC3 lentivirus transfection in cells. Muscle weight, blood glucose and grip strength were measured in mice. Hematoxylin and eosin (H&E) staining was performed to determine changes in muscle fiber size. To investigate the effects of P300 on autophagy and myofiber remodeling, a P300 specific inhibitor, c646, was utilized. 3-Methyladenine (3-MA) was utilized to inhibit autophagosomes formation, and chloroquine (CQ) was used to block autophagic flux. KEY FINDINGS: Phosphorylation of P300 in response to PA enhanced its activity and subsequently suppressed autophagic flux, leading to atrophy-related morphological and molecular changes in myotubes. Inhibition of P300 reestablished autophagic flux and ameliorated PA-induced myotubes atrophy. However, this effect was largely abolished by co-treatment with the autophagy inhibitor CQ. In vivo results demonstrated that inhibition of P300 partially rescued muscle wasting in db/db mice, accompanied with autophagy reactivation. SIGNIFICANCE: The findings revealed that T2D-induced overactivation of P300 contributes to muscle atrophy by blocking autophagic flux.


Assuntos
Autofagia/fisiologia , Diabetes Mellitus Tipo 2/metabolismo , Proteína p300 Associada a E1A/metabolismo , Atrofia Muscular/metabolismo , Animais , Linhagem Celular , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/patologia , Proteína p300 Associada a E1A/genética , Força da Mão/fisiologia , Masculino , Camundongos , Camundongos Transgênicos , Atrofia Muscular/genética , Atrofia Muscular/patologia , Mioblastos/metabolismo , Mioblastos/patologia
20.
PLoS One ; 15(8): e0236555, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32756598

RESUMO

INTRODUCTION: The active workforce is increasingly aging. However workload, as well as working time and intensity, sometimes remains unchanged. This can be an even more critical situation in older people, since occupational exposure associated with aging, will further reduce the muscle's ability to generate energy, which in turn facilitates the development of these age-related syndromes. This study aims to identify the normative values of handgrip strength for Portuguese workers in the automotive industry. METHODS: About 1225 employees were invited to participate in the study. The final sample consisted of 656 employees in the assembly area. The handgrip strength was measured in kilograms (kg) using the Jamar digital dynamometer. Sex-specific profiles of handgrip strength were designed by the Ordinary Least Square regression (OLS) analysis, where height, age, age squared, and height squared are entered into the models as determining factors of the maximum grip strength in both female and male groups. RESULTS: The peak mean values of handgrip strength in the group of women was 34 kg in the age group of 35-39 years, and in the group of men the peak mean was 52 kg in the age group of 25-34 years. The most pronounced decline in the female group appears in the age of 30-34 years of about 4 kg and the male group the decline occurs at 2kg below the peak force, in the age group of 40-57 year-olds. This study used a cut-off at 2 SD below by the sex-specific peak mean. CONCLUSION: Normative values can help delineate the career path of workers because they portray risk values according to age, height, and gender. The normative values assist health and engineering professionals and ergonomists in adjusting task demands to the morphological and strength characteristics of the workers.


Assuntos
Envelhecimento/fisiologia , Força da Mão/fisiologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Portugal/epidemiologia , Valores de Referência , Fatores Sexuais
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