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1.
J Pharm Pharmacol ; 74(10): 1406-1426, 2022 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-36215694

RESUMO

OBJECTIVES: Three-dimensional printing (3DP) has gained importance worldwide recently as a novel drug manufacturing technology. 3DP technologies are suitable in the pharmaceutical field because of having the potential in personalized medicine. The aim of this review is to present an overview of the use of 3DP technologies in pharmaceutical area, their working principles and critical process parameters. In addition, this review presents an innovative approach that evaluates the use of 3DP technologies on disease to disease. KEY FINDINGS: This review covers the potential use of 3DP technologies in different diseases by evaluating them on a research basis. These diseases can be summarized as cardiovascular, neurological, respiratory, oncological, inflammatory, vaginal, dermatological and other diseases. It has been focussed on manuscripts that published after 2015. Studies on the use of 3DP in each disease group have been systematically reviewed by considering the methods, types of printers used and the prepared dosage forms. Oral formulations (tablets and films), implants, topical systems and vaccines are some of the examples of the mentioned dosage forms. SUMMARY: This review presented a systematic and novel overview of the use of 3DP in the treatment of different clinical disorders.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Formas de Dosagem , Medicina de Precisão/métodos , Comprimidos , Tecnologia Farmacêutica/métodos
2.
J Control Release ; 351: 444-455, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36184971

RESUMO

3D printing in the pharmaceutical and healthcare settings is expanding rapidly, such as the rapid prototyping of orthotics, dental retainers, drug-loaded implants, and pharmaceutical solid oral dosage forms. Through 3D printing, we have the capability to precisely control dose, release kinetics, and several aesthetic features of dosage forms such as colour, shape, and texture. Additionally, polypills can be created with combinations of medications in one solid dosage form at completely customisable strengths that would be extremely difficult to obtain commercially. As the technology and formulations developed through 3D printing are expanding, the development of new hybrid materials to obtain superior formulations are also gaining momentum. In this review we collate data on the importance of developing hybrid formulations of polymers, drugs and excipients necessary to produce reliable and high-quality 3D printed dosage forms with a special emphasis on fused deposition modelling (FDM). FDM technology is one of the most widely used forms of 3D printing and has demonstrated compatibility with unique polymer-based hybrids to allow for enhanced drug delivery, protection of thermolabile drugs, modifiable release kinetics, and more. The data collated covers different categories of hybrids as well as the methods used to fabricate them, and their respective effects on the properties of 3D printed solid oral dosage forms. Therefore, this review will provide an overview of upcoming and emerging trends in pharmaceutical 3D printing formulation compositions.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Liberação Controlada de Fármacos , Excipientes/farmacologia , Composição de Medicamentos , Polímeros/farmacologia , Formas de Dosagem , Comprimidos
3.
Int J Pharm ; 628: 122293, 2022 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-36252640

RESUMO

The high degree of precision and control of 3D printing has given formulators the autonomy to engineer sophisticated and personalised medicines, starting a revolution in pharmaceutics. In addition, dosage forms with tailored drug release profile can be produced by changing some parameters of the 3D printing processes. Therefore, 3D printed medicines must be characterised in an orthogonal approach, to establish their physicochemical and biopharmaceutical features, and consequently to understand how these characteristics can be customised by changing the formulation and process parameters to ensure medicines' safety and efficacy. Given the recent regulation and commercialisation of 3D printed medicines, several methods and techniques have been transposed from official compendia; however, formulators must still make a critical assessment of their practical implications. A comprehensive review of the findings obtained by the characterisation of 3D printed oral dosage forms using traditional and advanced techniques is therefore presented here, to drive formulators towards a rational pharmaceutical development pathway. The characterisation methods have been classified in terms of their physicochemical or biopharmaceutical character. Interestingly, beyond the rise of modern characterisation techniques, the reassessment of data obtained by traditional methods has provided knowledge and a solid foundation to support the evolution of 3D printing techniques in pharmaceutics.


Assuntos
Produtos Biológicos , Tecnologia Farmacêutica , Tecnologia Farmacêutica/métodos , Liberação Controlada de Fármacos , Impressão Tridimensional , Formas de Dosagem
4.
J Control Release ; 351: 407-431, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36122897

RESUMO

Oral solid dosage form is currently the most common used form of drug. 3D Printing, also known as additive manufacturing (AM), can quickly print customized and individualized oral solid dosage form on demand. Compared with the traditional tablet manufacturing process, 3D Printing has many advantages. By rationally selecting the formulation composition and cleverly designing the printing structure, 3D printing can improve the solubility of the drug and achieve precise modify of the drug release. 3D printed oral solid dosage form, however, still has problems such as limitations in formulation selection. And the selection process of the formulation lacks scientificity and standardization. Structural design of some 3D printing approaches is relatively scarce. This article reviews the formulation selection and structure design of 3D printed oral solid dosage form, providing more ideas for achieving modified drug release and solubility improvement of 3D printed oral solid dosage form through more scientific and extensive formulation selection and more sophisticated structural design.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Solubilidade , Liberação Controlada de Fármacos , Comprimidos/química , Formas de Dosagem
5.
Int J Pharm ; 625: 122066, 2022 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-35926751

RESUMO

Three-dimensional (3D) printing has been gaining attention as a new technological approach to obtain immediate release (IR) dosage forms. The versatility conferred by 3D printing techniques arises from the suitability of using different polymeric materials in the production of solids with different porosities, geometries, sizes, and infill patterns. The appropriate choice of polymer can facilitate in reaching IR specifications and afford other specific properties to 3D printed solid dosage forms. This review aims to provide an overview of the polymers that have been employed in the development of IR 3D printed dosage forms, mainly considering their in vitro drug release behaviour. The physicochemical and mechanical properties of the IR 3D printed dosage forms will also be discussed, together with the manufacturing process strategies. Up to now, methacrylic polymers, cellulosic polymers, vinyl derivatives, glycols and different polymeric blends have been explored to produce IR 3D printed dosage forms. Their effects on drug release profiles are critically discussed here, giving a complete overview to drive formulators towards a rational choice of polymeric material and thus contributing to future studies in 3D printing of pharmaceuticals.


Assuntos
Polímeros , Tecnologia Farmacêutica , Formas de Dosagem , Liberação Controlada de Fármacos , Polímeros/química , Impressão Tridimensional , Comprimidos/química , Tecnologia Farmacêutica/métodos
6.
Int J Pharm ; 624: 122046, 2022 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-35908634

RESUMO

The introduction of three-dimensional (3D) printing in the pharmaceutical field has made great strides towards innovations in the way drugs are designed and manufactured. In this study, digital light processing (DLP) technique was used to fabricate oral dosage forms of different shapes with zolpidem tartrate (ZT), incorporated within its therapeutic range. Formulation factors, such as poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 (PEG 400) ratio, as well as water content, were varied in combination with the surface area/volume (SA/V) ratio to achieve immediate drug release. Hypromellose (HPMC) was used as a stabilizing agent of photoreactive suspensions in an attempt to prevent drug sedimentation and subsequent variations in drug content uniformity. Oral dosage forms with doses in the range from 0.15 mg to 6.37 mg, showing very rapid and rapid drug dissolution, were successfully fabricated, confirming the potential of this technique in drug manufacturing with the ability to provide flexible dose adjustments and desirable release profiles by varying formulation factors and geometry of 3D models. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and scanning electron microscopy (SEM) showed that ZT remained in a crystalline form within printed dosage forms and no interactions were found between ZT and polymers.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Formas de Dosagem , Liberação Controlada de Fármacos , Polietilenoglicóis/química , Comprimidos/química , Tecnologia Farmacêutica/métodos , Zolpidem
7.
Int J Pharm ; 624: 121991, 2022 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-35809833

RESUMO

Pharmaceutical compounding is a core activity in the preparation of patient-specific dosage forms. In the current study we aimed to investigate whether 3D printing could be employed for the preparation of pediatric-friendly personalized dosage forms that fulfil the acceptance criteria specified in the pharmacopoeias for conventional dosage forms. We then compared the 3D printed dosage forms with the same formulations prepared with mold-casting, a method frequently applied during pharmaceutical compounding. The molded dosage forms failed to pass most of the quality control tests, including the mass uniformity and content uniformity tests, as well as dose accuracy, contrary to the 3D printed, which not only passed all tests but also enabled precision overdose adjustment. Hence, 3D printing of chocolate-based dosage forms may effectively serve as an acceptable alternative method to mold casting in compounding patient-specific medication at the point-of-care.


Assuntos
Chocolate , Composição de Medicamentos/métodos , Impressão Tridimensional , Tecnologia Farmacêutica/métodos , Criança , Formas de Dosagem , Composição de Medicamentos/normas , Humanos , Preparações Farmacêuticas , Controle de Qualidade , Tecnologia Farmacêutica/tendências
8.
Int J Pharm ; 624: 122013, 2022 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-35839981

RESUMO

In order to expand the limited portfolio of available polymer-based excipients for fabricating three-dimensional (3D) printed pharmaceutical products, Lipid-based excipients (LBEs) have yet to be thoroughly investigated. The technical obstacle of LBEs application is, however their crystalline nature that renders them very brittle and challenging for processing via 3D-printing. In this work, we evaluated the functionality of LBEs for filament-based 3D-printing of oral dosage forms. Polyglycerol partial ester of palmitic acid and polyethylene glycols monostearate were selected as LBEs, based on their chemical structure, possessing polar groups for providing hydrogen-bonding sites. A fundamental understanding of structure-function relationship was built to screen the critical material attributes relevant for both extrusion and 3D-printing processes. The thermal behavior of lipids, including the degree of their supercooling, was the critical attribute for their processing. The extrudability of materials was improved through different feeding approaches, including the common powder feeding and a devised liquid feeding setup. Liquid feeding was found to be more efficient, allowing the production of filaments with high flexibility and improved printability. Filaments with superior performance were produced using polyglycerol ester of palmitic acid. In-house designed modifications of the utilized 3D-printer were essential for a flawless processing of the filaments.


Assuntos
Excipientes , Ácido Palmítico , Formas de Dosagem , Liberação Controlada de Fármacos , Ésteres , Excipientes/química , Pós , Impressão Tridimensional , Comprimidos/química , Tecnologia Farmacêutica/métodos
9.
Drug Dev Ind Pharm ; 48(3): 79-97, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35786119

RESUMO

Development and optimization of orally administered drug products often require bio-predictive tools to help with informing formulation and manufacturing decisions. Reliable bio-predictive dissolution toolkits not only allow rational development of target formulations without having to conduct excessive in vivo studies but also help in detecting critical material attributes (CMAs), critical formulation variables (CFVs), or critical process parameters (CPPs) that could impact a drug's in vivo performance. To provide early insights for scientists on the development of a bio-predictive method for drug product development, this review summarizes current phase-appropriate bio-predictive dissolution approaches applicable to address typical concerns on solubility-limited absorption, food effect, achlorhydria, development of extended-release formulation, clinically relevant specification, and biowaiver. The selection of an in vitro method which can capture the key rate-limiting step(s) of the in vivo dissolution and/or absorption is considered to have a better chance to produce a meaningful in vitro-in vivo correlation (IVIVC) or in vitro-in vivo relationship (IVIVR).


Assuntos
Desenvolvimento de Medicamentos , Administração Oral , Preparações de Ação Retardada , Formas de Dosagem , Solubilidade
10.
Mol Pharm ; 19(9): 3007-3025, 2022 09 05.
Artigo em Inglês | MEDLINE | ID: mdl-35848076

RESUMO

Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs' dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.


Assuntos
Percepção , Paladar , Administração Oral , Idoso , Criança , Formas de Dosagem , Composição de Medicamentos/métodos , Liberação Controlada de Fármacos , Humanos , Solubilidade
11.
Eur J Pharm Sci ; 175: 106221, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35662635

RESUMO

On demand production of totally customizable combinative preparations is a central goal of a patient-centric pharmaceutical supply chain. Additive manufacturing techniques like fused deposition modeling (FDM) could be key technologies towards such individualized dosage forms. As so far only a limited number of studies on 3D printed combinative preparations applying FDM have been reported, a core-shell dosage form was the focus of the present study. Dosage forms with an initial and a sustained release part with theophylline as model API were successfully produced applying a dual nozzle FDM 3D printer. Investigations identified microstructural defects at the interface between the two formulations by means of µCT analysis. Dissolution testing proved the achievement of the intended release profile. In combination with additionally characterized release profile of single material prints of different shapes, the combinative release profiles could be predicted by developing model equations and taking into account the geometric composition. As these model approaches can accordingly facilitate the prediction of API release from 3D printed combinative preparations with only data from single material release. This is a first step towards a truly individualized and reliable patient-centric pharmaceutical supply via 3D printing.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Formas de Dosagem , Composição de Medicamentos/métodos , Liberação Controlada de Fármacos , Humanos , Cinética , Preparações Farmacêuticas , Comprimidos/química , Tecnologia Farmacêutica/métodos
12.
Int J Pharm ; 623: 121928, 2022 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-35718250

RESUMO

Given the benefits of high printing precision and capability, the selective laser sintering technique has been used to manufacture medicines and implants with unique engineering and functional properties. Using homogenized beams with a reduced thermal gradient and a larger diameter as an alternative energy source, the thermal stability and production efficiency of powder bed fusion would be improved. Herein, a novel homogenized spot melting (HSM) technology for pharmaceutical preparation was developed in this study. The melting behavior of typical pharmaceutical polymers under a homogenized spot was determined. A crystalline polymer with a low melting point was used as a solid binder, and the HSM printability and formation of drug-loaded formulations were explored. Oral solid dosage forms with different morphological and dissolution designs were prepared and evaluated under optimal formulation and process conditions. It was observed that HSM reduced the surface temperature distribution of the powder bed and improved the printability of drugs and excipients. Crystalline PEG 8000 with suitable flowability and heat conduction efficiency in the molten state was preferable for HSM printing. Incorporating 40% PEG 8000 as a solid binder was an effective strategy for HSM processing of unfused or unstable powders. Solid preparations with different structures and dissolution behaviors were successfully printed, suggesting that HSM is a promisingtechnique for personalized medicine.


Assuntos
Excipientes , Impressão Tridimensional , Formas de Dosagem , Liberação Controlada de Fármacos , Excipientes/química , Polímeros/química , Pós/farmacologia , Comprimidos/química , Tecnologia Farmacêutica/métodos
13.
J Pharm Sci ; 111(9): 2562-2570, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35469835

RESUMO

In an effort to combine a child-friendly dosage form for medication administration in hospitalized pediatric patients and a user-friendly automated process for its preparation by health-care providers, the current study proposes a method for drug administration with breakfast using semi-solid extrusion 3D printing. Cereal was used as the platform carrier of the hydrophobic ibuprofen and the hydrophilic paracetamol to develop the drug loaded cereal ink. Rheological analysis was performed to identify the cereal ink with optimum viscosity for extrusion printing. Drug distribution and crystallinity within the printed cereal were assessed with confocal Raman microscopy and thermal and X-ray diffraction analysis, respectively, indicating molecular dispersion of both drugs within the cereal. High cereal porosity was associated with a higher milk absorption capacity and a decrease in their flexural force upon immersion in milk. Dissolution studies were performed in biorelevant media under fasted and fed state conditions and in the presence of full-fat and low-fat milk showing dissolution enhancement of the poorly soluble ibuprofen in the presence of the higher fat content milk. Concealing drug administration under the auspice of this essential daily eating habit is expected to facilitate overcoming adherence barriers to medication intake by pediatric patients within a hospital setting.


Assuntos
Grão Comestível , Ibuprofeno , Desjejum , Criança , Formas de Dosagem , Liberação Controlada de Fármacos , Hospitais , Humanos , Preparações Farmacêuticas , Impressão Tridimensional
14.
Hosp. domic ; 6(2)abr./jun. 2022. ilus
Artigo em Espanhol | IBECS | ID: ibc-209264

RESUMO

El paciente domiciliario de 76 años acude a la farmacia sita en Alfaz del Pi (Alicante) a retirar su medicación. Durante el acto de dispensación y tras observar la amplia farmacoterapia, se le ofrece formar parte del Servicio de Sistema Personalizado de Dosificación (SPD).Durante los 11 meses que el paciente domiciliario forma parte del Servicio, el médico le modifica 38 veces el tratamiento. Con la ayuda del SPD, el paciente ha aumentado la adherencia a su amplia polifarmacia y consecuentemente ha mejorado su calidad de vida y disminuir el número de comprimidos diarios.Con la participación del farmacéutico en el Sistema de Salud a través de los SPD, se consigue por un lado evitar los posibles problemas relacionados con la medicación, evitar los resultados negativos asociados a la misma, mejorar la salud del paciente al aumentar la adherencia a los tratamientos y consecuentemente suponer un ahorro económico a la Sanidad Nacional. (AU)


The 76-year-old home-care patient goes to the pharmacy located in Alfaz del Pi (Alicante) to pick up his medication. During the act of dispensing and after observing the extensive pharmacotherapy, pharmacist offered him to be part of the Personalized Dosing System Service (SPD).During the 11 months that the home-care patient is part of the Service, the doctor modifies the treatment 38 times. With the help of the SPD, the home-care patient has increased adherence to his extensive polypharmacy and consequently has improved his quality of life and decreased the number of daily tablets.With the participation of the pharmacist in the Health System through the SPD, it is possible, on the one hand, to avoid possible problems related to the medication, avoid the negative results associated with it, improve the patient's health by increasing adherence to treatments and consequently suppose an economic saving to the National Health. (AU)


Assuntos
Humanos , Masculino , Idoso , Qualidade de Vida , Serviços de Assistência Domiciliar , Serviços Comunitários de Farmácia , Polimedicação , Cooperação e Adesão ao Tratamento , Formas de Dosagem
15.
Spectrochim Acta A Mol Biomol Spectrosc ; 272: 120996, 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35149485

RESUMO

Raman spectroscopy is an outstanding analytical tool increasingly utilized in the pharmaceutical field for the solid-state pharmaceutical drug analysis. In current study, the potential of Raman spectroscopy has been investigated for qualitative and quantitative analysis of solid dosage form of Losartan potassium. For this purpose, different solid dosage forms/concentrations of losartan potassium were prepared to compensate the commercially available pharmaceutical drug formulations and their Raman spectral data showed a gradual change in the specific Raman spectral features associated with the active pharmaceutical ingredient (API) of Losartan potassium as a function of change in the concentration. The Raman spectral data was analyzed by using Principal Component Analysis (PCA) for the classification of different spectral data sets of different concentrations of drug. Moreover, partial least square regression (PLSR) analysis was performed for monitoring the quantitative relation among different concentrations of Losartan potassium API and spectral data by constructing a predictive model. From the model, the value of root mean square error of calibration (RMSEC) and root mean square error of prediction (RMSEP) were observed to be 0.38 and 2.98 respectively and the value of goodness of fit was found to be 0.99. Furthermore, the quantity of unknown/blind sample of Losartan potassium formulation was also estimated by using PLSR model. From these results, it is demonstrated that Raman spectroscopy can be considered to be used for quick and reliable quantitative analysis of pharmaceutical solids.


Assuntos
Losartan , Análise Espectral Raman , Calibragem , Formas de Dosagem , Análise dos Mínimos Quadrados , Análise de Componente Principal , Análise Espectral Raman/métodos
16.
J Pharm Pharmacol ; 74(10): 1367-1390, 2022 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-35191505

RESUMO

OBJECTIVE: Additive manufacturing (AM), commonly known as 3D printing (3DP), has opened new frontiers in pharmaceutical applications. This review is aimed to summarise the recent development of 3D-printed dosage forms, from a pharmacists' perspective. METHODS: Keywords including additive manufacturing, 3D printing and drug delivery were used for literature search in PubMed, Excerpta Medica Database (EMBASE) and Web of Science, to identify articles published in the year 2020. RESULTS: For each 3DP study, the active pharmaceutical ingredients, 3D printers and materials used for the printing were tabulated and discussed. 3DP has found its applications in various dosage forms for oral delivery, transdermal delivery, rectal delivery, vaginal delivery, implant and bone scaffolding. Several topics were discussed in detail, namely patient-specific dosing, customisable drug administration, multidrug approach, varying drug release, compounding pharmacy, regulatory progress and future perspectives. AM is expected to become a common tool in compounding pharmacies to make polypills and personalised medications. CONCLUSION: 3DP is an enabling tool to fabricate dosage forms with intricate structure designs, tailored dosing, drug combinations and controlled release, all of which lend it to be highly conducive to personalisation, thereby revolutionising the future of pharmacy practice.


Assuntos
Sistemas de Liberação de Medicamentos , Farmacêuticos , Preparações de Ação Retardada , Formas de Dosagem , Liberação Controlada de Fármacos , Humanos , Impressão Tridimensional , Tecnologia Farmacêutica
17.
Int J Pharm ; 616: 121553, 2022 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-35131354

RESUMO

3D printing (3DP) by fused deposition modelling (FDM) is one of the most extensively developed methods in additive manufacturing. Optimizing printability by improving feedability, nozzle extrusion, and layer deposition is crucial for manufacturing solid oral dosage forms with desirable properties. This work aimed to use HPMCAS (AffinisolTM HPMCAS 716) to prepare filaments for FDM-3DP using hot-melt extrusion (HME). It explored and demonstrated the effect of HME-filament composition and fabrication on printability by evaluating thermal, mechanical, and thermo-rheological properties. It also showed that the HME-Polymer filament composition used in FDM-3DP manufacture of oral solid dosage forms provides a tailored drug release profile. HME (HAAKE MiniLab) and FDM-3DP (MakerBot) were used to prepare HME-filaments and printed objects, respectively. Two diverse ways of improving the mechanical properties of HME-filaments were deduced by changing the formulation to enable feeding through the roller gears of the printer nozzle. These include plasticizing the polymer and adding an insoluble structuring agent (talc) into the formulation. Experimental feedability was predicted using texture analysis results was a function of PEG concentration, and glass-transition temperature (Tg) values of HME-filaments. The effect of high HME screw speed (100 rpm) resulted in inhomogeneity of HME-filament, which resulted in inconsistency of the printer nozzle extrudate and printed layers. The variability of the glass-transition temperature (Tg) of the HME-filament supported by scanning electron microscopy (SEM) images of nozzle extrudates and the lateral wall of the printed tablet helped explain this result. The melt viscosity of HPMCAS formulations was investigated using a capillary rheometer. The high viscosity of unplasticized HPMCAS was concluded to be an additional restriction for nozzle extrusion. The plasticization of HPMCAS and the addition of talc into the formulation were shown to improve thickness consistency of printed layers (using homogeneous HME-filaments). A good correlation (R2 = 0.9546) between the solidification threshold (low-frequency oscillation test determined by parallel-plate rheometer) and Tg of HME-filaments was also established. Drug-loaded and placebo HPMCAS-based formulations were shown to be successfully printed, with the former providing tailored drug release profiles based on variation of internal geometry (infill).


Assuntos
Excipientes , Tecnologia Farmacêutica , Formas de Dosagem , Liberação Controlada de Fármacos , Metilcelulose/análogos & derivados , Impressão Tridimensional , Comprimidos , Tecnologia Farmacêutica/métodos
18.
Adv Drug Deliv Rev ; 182: 114133, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35104506

RESUMO

To use or not to use, that is the first decision to take regarding a drug product. This mandatory step for adherence dictates product efficacy. The determinants for such decision do not only rely on the priority of the therapeutic or preventive strategy, but are related to a complex network of perceptions, preferences, personal and cultural backgrounds, and results from previous experiences. Women's preferences for dosage forms and even for drug delivery routes have been mainly studied in the fields of contraception and HIV prevention (and their related multipurpose approaches). Much less attention has been devoted to other therapeutic or preventive strategies. In a time when patient-centred approaches and shared decisions are increasingly valued, considering women's preferences and their main determinants is essential for product development and selection. Such products will be more likely to be chosen and used as intended, increasing efficacy, and reducing the overall costs related with these treatments. This knowledge shall be integrated in early stages of product development. This article reviews the state of the art related with women's preferences and acceptance for different dosage forms and drug delivery routes involved in women's health. The methodologies used for collecting these data and their major drawbacks are discussed. Results obtained from acceptability studies and the main determinants for selection of preventive and treatment drug products are discussed as tools for new developments in the field.


Assuntos
Formas de Dosagem , Vias de Administração de Medicamentos , Preferência do Paciente , Saúde da Mulher , Comportamento de Escolha , Coleta de Dados , Feminino , Humanos
19.
Pharm Res ; 39(3): 599-610, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35194719

RESUMO

PURPOSE: To develop a new direct granule fed 3D printing method for manufacturing pharmaceutical solid dosage forms with porous structures using a thermal droplet deposition technology. METHODS: Eudragit® E PO was used as the model polymer, which is well-known to be not FDM printable without additives. Wet granulation was used to produce drug loaded granules as the feedstock. The flow and feedability of the granules were evaluated. The physicochemical properties and in vitro drug release performance of the granules and the printed tablets were fully characterised. RESULTS: Using the method developed by this study, Eudragit E PO was printed with a model drug into tablets with infills ranging from 30-100%, without additives. The drug was confirmed to be molecularly dispersed in the printed tablets. The printing quality and performances of the porous tablets were confirmed to be highly compliant with the pharmacopeia requirement. The level of infill density of the porous tablets had a significant effect on their in vitro drug release performance. CONCLUSION: This is the first report of thermal droplet deposition printing via direct granule feeding. The results of this study demonstrated that this new printing method can be used as a potentially valuable alternative for decentralised pharmaceutical solid dosage form manufacturing.


Assuntos
Impressão Tridimensional , Tecnologia Farmacêutica , Formas de Dosagem , Liberação Controlada de Fármacos , Porosidade , Comprimidos/química , Tecnologia Farmacêutica/métodos
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