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1.
Toxicon ; 161: 28-32, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30826471

RESUMO

In this retrospective series of 97 cases of manchineel fruit ingestion reported to French Poison Control Centers between 2009 and 2017, we investigated cases of poisoning due to manchineel fruit (from the Hippomane mancinella tree). This fruit is known to be responsible for oropharyngeal and gastrointestinal tract lesions and possibly hypotension and bradycardia (previously attributed to the presence of physostigmine). The most commonly observed clinical signs were oropharyngeal pain, abdominal pain, diarrhea and oropharyngeal irritation. No major gastrointestinal tract lesions were observed in the five cases in which upper gastrointestinal (GI) endoscopy was performed. One case of laryngeal edema and one case of bradycardia were observed, but analysis of the harvested fruits did not confirm the presence of physostigmine. Ingestion of manchineel fruit can cause mild abdominal pain and digestive irritation, requiring medical attention. Rarely, when several fruits have been ingested, severe oropharyngeal injury or hemodynamic disorders may require otorhinolaryngological consultation or cardiac monitoring for several hours, respectively.


Assuntos
Frutas/envenenamento , Hippomane/envenenamento , Intoxicação por Plantas/etiologia , Adolescente , Adulto , Idoso , Feminino , Hippomane/química , Humanos , Masculino , Pessoa de Meia-Idade , Fisostigmina/análise , Intoxicação por Plantas/diagnóstico , Centros de Controle de Intoxicações , Estudos Retrospectivos , Adulto Jovem
2.
Toxicon ; 157: 80-83, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30468757

RESUMO

The aim of this paper was to present the first report of Prosopis nigra poisoning of cattle in Argentina. Outbreaks occurred in five farms located in Salta and Santiago del Estero provinces. All animals were examined, euthanized and necropsied. Clinical signs included tongue protrusion, twitches and tremors of muscles of mastication, weight loss and lethargy. Severe atrophy of the masseter, buccinator and lingual muscles was observed, along with neuronal vacuolation in the nuclei of the trigeminal, facial, and hypoglossus nerves. These findings and the clinical signs are consistent with results obtained in animals, spontaneously and experimentally intoxicated with Prosopis juliflora in previous studies. Several species of this genus are native to Argentina. Farmers should be warned about the suspected toxicity by Prosopis nigra, since this species has wide geographical distribution in the country.


Assuntos
Doenças dos Bovinos/etiologia , Intoxicação por Plantas/veterinária , Prosopis/envenenamento , Animais , Argentina , Bovinos , Doenças dos Bovinos/diagnóstico , Surtos de Doenças/veterinária , Frutas/envenenamento , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/etiologia
3.
Cochrane Database Syst Rev ; 12: CD013230, 2018 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-30565220

RESUMO

BACKGROUND: Oral poisoning is a major cause of mortality and disability worldwide, with estimates of over 100,000 deaths due to unintentional poisoning each year and an overrepresentation of children below five years of age. Any effective intervention that laypeople can apply to limit or delay uptake or to evacuate, dilute or neutralize the poison before professional help arrives may limit toxicity and save lives. OBJECTIVES: To assess the effects of pre-hospital interventions (alone or in combination) for treating acute oral poisoning, available to and feasible for laypeople before the arrival of professional help. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL, ISI Web of Science, International Pharmaceutical Abstracts, and three clinical trials registries to 11 May 2017, and we also carried out reference checking and citation searching. SELECTION CRITERIA: We included randomized controlled trials comparing interventions (alone or in combination) that are feasible in a pre-hospital setting for treating acute oral poisoning patients, including but potentially not limited to activated charcoal (AC), emetics, cathartics, diluents, neutralizing agents and body positioning. DATA COLLECTION AND ANALYSIS: Two reviewers independently performed study selection, data collection and assessment. Primary outcomes of this review were incidence of mortality and adverse events, plus incidence and severity of symptoms of poisoning. Secondary outcomes were duration of symptoms of poisoning, drug absorption, and incidence of hospitalization and ICU admission. MAIN RESULTS: We included 24 trials involving 7099 participants. Using the Cochrane 'Risk of bias' tool, we assessed no study as being at low risk of bias for all domains. Many studies were poorly reported, so the risk of selection and detection biases were often unclear. Most studies reported important outcomes incompletely, and we judged them to be at high risk of reporting bias.All but one study enrolled oral poisoning patients in an emergency department; the remaining study was conducted in a pre-hospital setting. Fourteen studies included multiple toxic syndromes or did not specify, while the other studies specifically investigated paracetamol (2 studies), carbamazepine (2 studies), tricyclic antidepressant (2 studies), yellow oleander (2 studies), benzodiazepine (1 study), or toxic berry intoxication (1 study). Eighteen trials investigated the effects of activated charcoal (AC), administered as a single dose (SDAC) or in multiple doses (MDAC), alone or in combination with other first aid interventions (a cathartic) and/or hospital treatments. Six studies investigated syrup of ipecac plus other first aid interventions (SDAC + cathartic) versus ipecac alone. The collected evidence was mostly of low to very low certainty, often downgraded for indirectness, risk of bias or imprecision due to low numbers of events.First aid interventions that limit or delay the absorption of the poison in the bodyWe are uncertain about the effect of SDAC compared to no intervention on the incidence of adverse events in general (zero events in both treatment groups; 1 study, 451 participants) or vomiting specifically (Peto odds ratio (OR) 4.17, 95% confidence interval (CI) 0.30 to 57.26, 1 study, 25 participants), ICU admission (Peto OR 7.77, 95% CI 0.15 to 391.93, 1 study, 451 participants) and clinical deterioration (zero events in both treatment groups; 1 study, 451 participants) in participants with mixed types or paracetamol poisoning, as all evidence for these outcomes was of very low certainty. No studies assessed SDAC for mortality, duration of symptoms, drug absorption or hospitalization.Only one study compared SDAC to syrup of ipecac in participants with mixed types of poisoning, providing very low-certainty evidence. Therefore we are uncertain about the effects on Glasgow Coma Scale scores (mean difference (MD) -0.15, 95% CI -0.43 to 0.13, 1 study, 34 participants) or incidence of adverse events (risk ratio (RR) 1.24, 95% CI 0.26 to 5.83, 1 study, 34 participants). No information was available concerning mortality, duration of symptoms, drug absorption, hospitalization or ICU admission.This review also considered the added value of SDAC or MDAC to hospital interventions, which mostly included gastric lavage. No included studies investigated the use of body positioning in oral poisoning patients.First aid interventions that evacuate the poison from the gastrointestinal tractWe found one study comparing ipecac versus no intervention in toxic berry ingestion in a pre-hospital setting. Low-certainty evidence suggests there may be an increase in the incidence of adverse events, but the study did not report incidence of mortality, incidence or duration of symptoms of poisoning, drug absorption, hospitalization or ICU admission (103 participants).In addition, we also considered the added value of syrup of ipecac to SDAC plus a cathartic and the added value of a cathartic to SDAC.No studies used cathartics as an individual intervention.First aid interventions that neutralize or dilute the poison No included studies investigated the neutralization or dilution of the poison in oral poisoning patients.The review also considered combinations of different first aid interventions. AUTHORS' CONCLUSIONS: The studies included in this review provided mostly low- or very low-certainty evidence about the use of first aid interventions for acute oral poisoning. A key limitation was the fact that only one included study actually took place in a pre-hospital setting, which undermines our confidence in the applicability of these results to this setting. Thus, the amount of evidence collected was insufficient to draw any conclusions.


Assuntos
Primeiros Socorros/métodos , Envenenamento/terapia , Acetaminofen/envenenamento , Analgésicos não Entorpecentes/envenenamento , Antidepressivos/envenenamento , Antídotos/uso terapêutico , Benzodiazepinas/envenenamento , Carbamazepina/envenenamento , Catárticos/uso terapêutico , Carvão Vegetal/uso terapêutico , Frutas/envenenamento , Humanos , Ipeca/uso terapêutico , Envenenamento/etiologia , Viés de Publicação , Ensaios Clínicos Controlados Aleatórios como Assunto , Thevetia/envenenamento
4.
Aust Vet J ; 96(10): 408-410, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30255582

RESUMO

CASE REPORT: Ingestion of pomegranates was associated with the deaths of 9 of 35 young cattle; 8 were found dead without any prior clinical signs being noted and 1 animal was observed to be weak with pale-pink mucous membranes. Gross pathological changes included widespread subcutaneous and serosal haemorrhages and the liver showed an enhanced acinar or 'nutmeg-like' pattern. The significant histopathological lesion was severe, acute periacinar to midzonal hepatocellular necrosis. These findings were considered characteristic of a hepatotoxicosis; however, other than the possible involvement of pomegranates, no known hepatotoxins were detected in the pasture or water sources. CONCLUSION: Consumption of large quantities of whole pomegranates is capable of causing severe hepatic necrosis resulting in the death of cattle. At this stage it is unknown whether the toxic principle is within the pomegranates or produced by a microbe associated with the deteriorating fruit.


Assuntos
Doenças dos Bovinos/etiologia , Hepatopatias/veterinária , Lythraceae/envenenamento , Intoxicação por Plantas/veterinária , Animais , Bovinos , Doenças dos Bovinos/patologia , Surtos de Doenças/veterinária , Frutas/envenenamento , Hemorragia/veterinária , Hepatopatias/etiologia , Hepatopatias/patologia , Masculino
5.
Mymensingh Med J ; 27(3): 650-653, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30141459

RESUMO

Averrhoa bilimbi found in bilimbi tree is a well known fruits of warm climates, found throughout Bangladesh, India, Myanmar and South East Asian countries. This fruit contents high level of oxalate. Acute renal failure due to tubular necrosis caused by oxalate crystal has been reported. We present a patient who developed acute kidney injury following ingestion of bilimbi fruit juice and had complete recovery with conservative management and concluded that star fruit and bilimbi fruit juice should be avoided in CKD and on dialysis patients.


Assuntos
Averrhoa , Frutas , Doenças do Sistema Nervoso , Oxalatos , Averrhoa/química , Bangladesh , Frutas/envenenamento , Humanos , Índia , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/etiologia , Oxalatos/envenenamento
6.
Clin Toxicol (Phila) ; 56(8): 790-794, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29323540

RESUMO

CONTEXT: Among the numerous varieties of squash that exist, some are edible while other bitter-tasting ones are not fit for human consumption. Cases of confusion seem to be multiplying and are characterized by digestive problems (diarrhea, vomiting, and abdominal pain). METHODS: This is a descriptive retrospective study of cases of exposure reported to French Poison Control Centers between 1 January 2012 and 12 December 2016. RESULTS: 353 patients were included, with 71.7% belonging to collective cases of poisoning. The male to female sex ratio was 0.75 for an average age of 38.2 ± 23.6 years. The circumstances of exposure were dietary for 337 patients (95.5%). The majority of the squash consumed was purchased at a store (55.8%) but some also came from the garden (25.5%). 204 patients (57.8%) mostly presented with diarrhea, vomiting, abdominal pain, sometimes with the consequent dehydration, hypotension, tachycardia, headaches, or vertigo. There were no deaths or severe (Poisoning Severity Score (PSS) 3) cases, but there were 14 patients (4.0%) of moderate severity, 190 patients (53.8%) of minor severity (PSS 1), and 149 patients (42.2%) without severity (PSS 0) but among which we include the bitter taste of the squash. The average age of PSS 2 patients was significantly (p = .003) older than that of the PSS <2 patients. CONCLUSION: As the first consequential series in Europe, our study shows that exposure to non-edible squash is frequent. Usually benign, poisoning could be the consequence of the irritating effect of certain cucurbits, the molecules responsible for the taste and toxicity of the fruits. In terms of prevention therefore, we recommend disposing of any squash with a bitter taste.


Assuntos
Cucurbita/envenenamento , Frutas/envenenamento , Centros de Controle de Intoxicações/estatística & dados numéricos , Envenenamento/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , França/epidemiologia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
7.
Med J Malaysia ; 73(6): 453-454, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30647232

RESUMO

Datura plants contain anticholinergic properties. Consumers may present with a spectrum of anticholinergic symptoms, including hallucination, agitation, tachycardia, delirium, hyperthermia, and dilated pupils. Prompt identification of the symptoms with appropriate treatment can be life-saving. Some patients might not be able to provide history and therefore recognition of toxidromes is imperative. Awareness should be built among the public who may be exposed to such fruits or plants.


Assuntos
Datura/envenenamento , Frutas/envenenamento , Intoxicação por Plantas/diagnóstico , Adulto , Inibidores da Colinesterase/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fisostigmina/uso terapêutico , Intoxicação por Plantas/tratamento farmacológico , Intoxicação por Plantas/etiologia
9.
Hum Exp Toxicol ; 37(4): 338-342, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28421827

RESUMO

Nandina domestica is grown as an ornamental plant in the United States but has also been reported as an invasive plant in a number of states. Parts of the plant, particularly the berries, contain cyanogenic glycosides that convert to hydrogen cyanide when ingested. This investigation characterized N. domestica ingestions involving patients of age 5 years and less reported to Texas poison centers during 2000-2015. There were 875 total N. domestica ingestions. A seasonal pattern was observed with the highest proportion of ingestions occurring in March (18.5%) and April (14.7%). The patients were male in 55.0% of the cases; 40.8% of the patients were of age 1 and 37.0% of age 2. Berries were specifically mentioned in 709 ingestions, of which 57.3% involved one berry and 28.5% an unknown number of berries. The ingestion occurred at the patient's own residence in 92.9% of the cases, and the patient was managed on site in 97.0%. The most frequently reported clinical effects were vomiting (3.7%), abdominal pain (1.0%), diarrhea (0.9%), and nausea (0.7%). In conclusion, N. domestica ingestions among young children generally do not result in serious outcomes and can be managed successfully outside of a healthcare facility.


Assuntos
Acidentes Domésticos , Berberidaceae/envenenamento , Centros de Controle de Intoxicações , Envenenamento/epidemiologia , Distribuição por Idade , Animais , Pré-Escolar , Bases de Dados Factuais , Feminino , Frutas/envenenamento , Humanos , Lactente , Masculino , Envenenamento/diagnóstico , Envenenamento/terapia , Estudos Retrospectivos , Medição de Risco , Estações do Ano , Texas/epidemiologia , Fatores de Tempo
12.
Clin Toxicol (Phila) ; 55(7): 624-628, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28443386

RESUMO

BACKGROUND: Star fruit (SF) is a commonly available fruit produced and eaten in tropical and subtropical countries. Since 1993, various reports have described neurotoxicity after eating SF, but this clinical condition remains unfamiliar. We aimed to describe this clinical entity, the role of renal dysfunction in this disorder, treatment strategies, and prognosis of patients with SF intoxication. METHODS: We conducted a search of PubMed and Google Scholar databases from 1993 to 2016. We included reports describing patients with a clear history of SF ingestion with acute symptoms. We described the demographic characteristics, reported SF intake, treatments used, and outcomes. RESULTS: We reviewed totally 126 patients (male:female = 1.5:1) from 33 articles with mean age 54.4 ± 11 (range: 30-84). The most common symptom was hiccups (65%), whereas confusion and seizure were the most common symptoms associated with mortality (42% and 61%, respectively). Pre-intoxication renal function also affected mortality. While there was no mortality in patients with normal renal function (NRF), the mortality of patients among reported cases with chronic renal insufficiency and end-stage renal disease undergoing dialysis were 36% and 27%, respectively. With the inclusion of patients reported to have NRF, the overall mortality was 24%. Consistently, the number of SF consumed was substantially higher in the patients with NRF than those with renal functional impairment. The most common treatment strategy was hemodialysis (59%). CONCLUSIONS: Patients with impaired renal function were at higher risks of SF intoxication. Severe neurologic symptoms mandate immediate medical intervention because of the association between their occurrence and high mortalities. Toxin removal through dialysis, rather than symptomatic relief, seems to be beneficial to patient survival. Early and continuous dialysis appears to alleviate severe symptoms and prevent symptom rebounds.


Assuntos
Averrhoa/envenenamento , Doenças Transmitidas por Alimentos/etiologia , Frutas/envenenamento , Falência Renal Crônica/complicações , Rim/fisiopatologia , Síndromes Neurotóxicas/etiologia , Insuficiência Renal Crônica/complicações , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Doenças Transmitidas por Alimentos/mortalidade , Doenças Transmitidas por Alimentos/fisiopatologia , Doenças Transmitidas por Alimentos/terapia , Humanos , Falência Renal Crônica/mortalidade , Falência Renal Crônica/fisiopatologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Síndromes Neurotóxicas/mortalidade , Síndromes Neurotóxicas/fisiopatologia , Síndromes Neurotóxicas/terapia , Diálise Renal , Insuficiência Renal Crônica/mortalidade , Insuficiência Renal Crônica/fisiopatologia , Insuficiência Renal Crônica/terapia , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Resultado do Tratamento
15.
Euro Surveill ; 20(29): 21192, 2015 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-26227370

RESUMO

In May 2013, Italy declared a national outbreak of hepatitis A, which also affected several foreign tourists who had recently visited the country. Molecular investigations identified some cases as infected with an identical strain of hepatitis A virus subgenotype IA. After additional European Union/European Economic Area (EU/EEA) countries reported locally acquired and travel-related cases associated with the same outbreak, an international outbreak investigation team was convened, a European outbreak case definition was issued and harmonisation of the national epidemiological and microbiological investigations was encouraged. From January 2013 to August 2014, 1,589 hepatitis A cases were reported associated with the multistate outbreak; 1,102 (70%) of the cases were hospitalised for a median time of six days; two related deaths were reported. Epidemiological and microbiological investigations implicated mixed frozen berries as the vehicle of infection of the outbreak. In order to control the spread of the outbreak, suspected or contaminated food batches were recalled, the public was recommended to heat-treat berries, and post-exposure prophylaxis of contacts was performed. The outbreak highlighted how large food-borne hepatitis A outbreaks may affect the increasingly susceptible EU/EEA general population and how, with the growing international food trade, frozen berries are a potential high-risk food.


Assuntos
Surtos de Doenças , Contaminação de Alimentos , Doenças Transmitidas por Alimentos/epidemiologia , Frutas/envenenamento , Vírus da Hepatite A/genética , Hepatite A/epidemiologia , Adolescente , Adulto , Pré-Escolar , Busca de Comunicante , Estudos Epidemiológicos , Europa (Continente)/epidemiologia , União Europeia , Feminino , Doenças Transmitidas por Alimentos/diagnóstico , Doenças Transmitidas por Alimentos/virologia , Alimentos Congelados/envenenamento , Alimentos Congelados/virologia , Frutas/virologia , Hepatite A/virologia , Vírus da Hepatite A/isolamento & purificação , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
16.
Euro Surveill ; 20(29): 21193, 2015 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-26227371

RESUMO

Epidemiological investigations of outbreaks of hepatitis A virus (HAV) and norovirus (NoV) infections in the European Union/European Economic Area (EU/EEA) in the last five years have highlighted frozen berries as a vehicle of infection. Given the increasing berry consumption in the EU over the last decades, we undertook a review of the existing evidence to assess the potential scale of threat associated with this product. We searched the literature and four restricted-access online platforms for outbreak/contamination events associated with consumption of frozen berries. We performed an evaluation of the sources to identify areas for improvement. The review revealed 32 independent events (i.e. outbreak, food contamination) in the period 1983­2013, of which 26 were reported after 2004. The identified pathogens were NoV, HAV and Shigella sonnei. NoV was the most common and implicated in 27 events with over 15,000 cases reported. A capture­recapture analysis was performed including three overlapping sources for the period 2005­2013. The study estimated that the event-ascertainment was 62%. Consumption of frozen berries is associated with increasing reports of NoV and HAV outbreaks and contamination events, particularly after 2003. A review of the risks associated with this product is required to inform future prevention strategies. Better integration of the available communication platforms and databases should be sought at EU/EEA level to improve monitoring, prevention and control of food-borne-related events.


Assuntos
Infecções por Caliciviridae/epidemiologia , Surtos de Doenças , Disenteria Bacilar/epidemiologia , Contaminação de Alimentos/análise , Doenças Transmitidas por Alimentos/epidemiologia , Alimentos Congelados/microbiologia , Frutas/microbiologia , Vírus da Hepatite A/isolamento & purificação , Hepatite A/epidemiologia , Adolescente , Adulto , Infecções por Caliciviridae/diagnóstico , Pré-Escolar , Disenteria Bacilar/diagnóstico , Estudos Epidemiológicos , Europa (Continente)/epidemiologia , União Europeia , Feminino , Doenças Transmitidas por Alimentos/diagnóstico , Doenças Transmitidas por Alimentos/microbiologia , Alimentos Congelados/envenenamento , Frutas/envenenamento , Hepatite A/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Norovirus/isolamento & purificação , Vigilância da População , Shigella sonnei/isolamento & purificação , Inquéritos e Questionários
17.
Bull Soc Pathol Exot ; 108(2): 139-43, 2015 Mar.
Artigo em Francês | MEDLINE | ID: mdl-25925815

RESUMO

Jatropha curcas L. is an inedible plant belonging to the Euphorbiaceae family that is growing in subtropical zones of all continents. We report a series of 24 cases of poisoning with J. curcas seeds or fruits reported to poison centers in Paris and Marseille between December 2000 and June 2014. Fifteen adults and 9 children ingested J. curcas seeds or fruits. All patients experienced gastrointestinal disorders, within the first hours following ingestion: nausea, vomiting, diarrhea and abdominal pain. Laboratory investigations performed in 10 patients revealed minor abnormalities: CK elevation (8 cases), dehydration (5 cases) with moderate elevation of serum creatinine levels (3 cases), and mildly increased serum bilirubin (8 cases). Complete remission of all clinical signs was observed within 48 hours in the 20 cases for which the outcome was known. Previously published cases of J. curcas poisoning were very similar to ours: As in our series, gastrointestinal disorders were always present. They were sometimes associated with neurological or cardiovascular signs, and hepatic or renal disorders; these were generally interpreted as complications of severe gastroenteritis, although direct toxic effects could not be formally excluded. In most cases, simple supportive measures were sufficient to ensure complete recovery within 24-48 hours. J Curcas poisoning incidence is certainly increasing because the plant is cultivated to produce biodiesel and is now largely present in most subtropical countries. As a consequence, local health professionals should be informed of the toxic properties of this plant.


Assuntos
Doenças Transmitidas por Alimentos/epidemiologia , Jatropha/envenenamento , Centros de Controle de Intoxicações , Adolescente , Adulto , Criança , Pré-Escolar , Comores/epidemiologia , Feminino , França/epidemiologia , Frutas/envenenamento , Humanos , Masculino , Pessoa de Meia-Idade , Nova Caledônia/epidemiologia , Paris/epidemiologia , Centros de Controle de Intoxicações/estatística & dados numéricos , Reunião/epidemiologia , Gestão de Riscos/estatística & dados numéricos , Adulto Jovem
18.
Angew Chem Int Ed Engl ; 52(49): 13067-70, 2013 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-24281890

RESUMO

Caramboxin: Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine-like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.


Assuntos
Lesão Renal Aguda/etiologia , Doenças Transmitidas por Alimentos/etiologia , Frutas/química , Frutas/envenenamento , Síndromes Neurotóxicas/etiologia , Neurotoxinas/envenenamento , Neurotoxinas/toxicidade , Plantas Tóxicas/química , Plantas Tóxicas/envenenamento , Lesão Renal Aguda/terapia , Animais , Produtos Biológicos , Frutas/toxicidade , Hipocampo/efeitos dos fármacos , Humanos , Ratos , Ratos Wistar , Diálise Renal
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