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1.
Chem Commun (Camb) ; 55(72): 10768-10771, 2019 Sep 05.
Artigo em Inglês | MEDLINE | ID: mdl-31432821

RESUMO

By covalent combination of a chiral amino acid, lipid, and achiral phenothiazine derivative, a reaction-based chiroptical probe, PTZ-D, was obtained. PTZ-D could self-assemble into a chiral organogel realizing the chirality transformation from a chiral amino acid to a self-assembled system and displaying unprecedented chiroptical monitoring of ClO- with switchable CPL signals.


Assuntos
Aminoácidos/química , Ácido Hipocloroso/análise , Luminescência , Imagem Óptica , Géis/síntese química , Géis/química , Estrutura Molecular , Tamanho da Partícula
2.
J Agric Food Chem ; 67(37): 10432-10447, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31466447

RESUMO

A composite nanogel was developed for cyanidin-3-O-glucoside (C3G) delivery by combining Maillard reaction and heat gelation. The starting materials utilized were ovalbumin, dextran, and pectin. C3G-loaded nanogel was spherical with a diameter of ∼185 nm, which was maintained over a wide range of pH and NaCl concentrations. The composite nanogel enhanced the chemical stability of C3G under accelerated degradation models and a simulated gastrointestinal tract. Clathrin-mediated, caveolae-mediated, and macropinocytosis-related endocytosis contributed to the higher cellular uptake of nano-C3G than that of free-C3G. The apparent permeability coefficients of C3G increased 2.16 times after nanoencapsulation. The transcytosis of the C3G-bearing nanogel occurred primarily through the clathrin-related pathway and macropinocytosis and followed the "common recycling endosomes-endoplasmic reticulum-Golgi complex-basolateral plasma membrane" route. Moreover, nano-C3G was more efficient in restoring the viability of cells and activities of endogenous antioxidant enzymes than free-C3G in oxidative models, which may be attributed to the former's high cellular absorption.


Assuntos
Antocianinas/química , Antocianinas/metabolismo , Antioxidantes/química , Antioxidantes/metabolismo , Portadores de Fármacos/química , Glucosídeos/química , Glucosídeos/metabolismo , Células CACO-2 , Composição de Medicamentos , Estabilidade de Medicamentos , Trato Gastrointestinal/metabolismo , Géis/química , Géis/metabolismo , Humanos , Concentração de Íons de Hidrogênio , Absorção Intestinal , Modelos Biológicos , Nanopartículas/química , Nanopartículas/metabolismo , Tamanho da Partícula
3.
J Agric Food Chem ; 67(28): 7935-7941, 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31264423

RESUMO

Involvement of DNA in gelation and microstructural properties of scallop (Patinopecten yessoensis) male gonad hydrolysates (SMGHs) and corresponding hybrid gel with κ-carrageenan (SMGHs/κ-C) was studied using DNase pretreatment. Although DNase pretreatment significantly transformed SMGHs from weak gels to liquid, it made SMGHs have a superior synergistic effect on gel formation with κ-C by evidence of 2.7-fold G' and 1.1-fold melting temperature. However, the relaxation time (T21 and T23), functional groups, and flocculation behavior were comparable between SMGHs/κ-C and SMGHs/DNase/κ-C. Moreover, SMGHs/DNase/κ-C exhibited a denser network with more numerous patches and larger void spaces. These results suggest that DNA contributes to the gel formation of SMGHs whereas restricts more cationic peptides in SMGHs to bind sulfate groups in κ-C during gel formation.


Assuntos
Carragenina/química , DNA/química , Gônadas/química , Pectinidae/química , Hidrolisados de Proteína/química , Animais , Desoxirribonucleases/química , Géis/química , Masculino , Pectinidae/genética
4.
Phys Chem Chem Phys ; 21(32): 17475-17493, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31328203

RESUMO

A set of disordered interacting building blocks may form ordered structures by means of a self-assembling process. An external intervention in the system by adding a chemical species or by applying forces leads to different self-assembly scenarios with the appearance of new structures. For instance, the formation of microtubules, gels, virus capsides, cells and living beings among others takes place by self-assembly under nonequilibrium conditions. A general evolution criterion able to account for why nature selects some structures outside equilibrium and not others is lacking. Nevertheless, progress in the understanding of nonequilibrium self-assembly (NESA) mechanisms has been made thanks to the formulation of models that take particular situations into consideration. We review recent efforts devoted to describing self-assembly out of equilibrium and we provide a reference linking several current concepts in order to help in the development of new models and experimental studies. We hope that the knowledge of the intimate mechanisms leading to the formation of structures will make the implementation of re-configurable and bio-inspired materials possible and give a simpler perspective on the understanding of the emergence of life.


Assuntos
Modelos Teóricos , Fenômenos Físicos , Fenômenos Biofísicos , Células/química , Géis/química , Cinética , Método de Monte Carlo , Nanopartículas/química , Polímeros/química , Termodinâmica , Vírus/química
6.
J Agric Food Chem ; 67(34): 9601-9610, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31334648

RESUMO

The influence of sucrose palmitate, Tween 20, and lecithin on the properties of heat-induced aggregates and cold-set gels of ß-lactoglobulin was studied based on an experimental mixture design with a fixed total emulsifier concentration. Emulsifiers were added to the protein solution before heating. Aggregate size and absolute values of ζ potential increased with the addition of emulsifiers, among which lecithin had the most pronounced effect. The water retention of the aggregates correlated positively with the aggregate size. Gels had reduced fracture stress and strains with increasing sucrose palmitate and decreasing Tween 20 contents. The fracture properties correlated with the ζ potentials of the aggregates, and larger aggregates led to gels with higher water-holding capacities. The emulsifiers hence influenced the gel properties indirectly via the aggregate properties. The impact of emulsifiers on food structures should therefore be considered when a food product is designed.


Assuntos
Emulsificantes/química , Lactoglobulinas/química , Lecitinas/química , Polissorbatos/química , Sacarose/análogos & derivados , Emulsões/química , Géis/química , Temperatura Alta , Agregados Proteicos , Sacarose/química , Viscosidade
7.
Nat Commun ; 10(1): 3029, 2019 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-31292444

RESUMO

With improving biofabrication technology, 3D bioprinted constructs increasingly resemble real tissues. However, the fundamental principles describing how cell-generated forces within these constructs drive deformations, mechanical instabilities, and structural failures have not been established, even for basic biofabricated building blocks. Here we investigate mechanical behaviours of 3D printed microbeams made from living cells and extracellular matrix, bioprinting these simple structural elements into a 3D culture medium made from packed microgels, creating a mechanically controlled environment that allows the beams to evolve under cell-generated forces. By varying the properties of the beams and the surrounding microgel medium, we explore the mechanical behaviours exhibited by these structures. We observe buckling, axial contraction, failure, and total static stability, and we develop mechanical models of cell-ECM microbeam mechanics. We envision these models and their generalizations to other fundamental 3D shapes to facilitate the predictable design of biofabricated structures using simple building blocks in the future.


Assuntos
Bioimpressão/métodos , Técnicas de Cultura de Células/métodos , Impressão Tridimensional , Engenharia Tecidual/métodos , Resinas Acrílicas/química , Animais , Materiais Biocompatíveis , Linhagem Celular Tumoral , Matriz Extracelular , Géis/química , Teste de Materiais , Metacrilatos/química , Camundongos , Células NIH 3T3
8.
Anal Bioanal Chem ; 411(23): 6155-6163, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31300857

RESUMO

Electrophoresis has demonstrated utility as tool for screening of small molecule modulators of protein-protein interactions and enzyme targets. Screening of large chemical libraries requires high-throughput separations. Such fast separation can be accessed by microchip electrophoresis. Here, microchip gel electrophoresis separations of proteins are achieved in 2.6 s with 1200 V/cm and 3-mm separation lengths. However, such fast separations can still suffer from limited overall throughput from sample introduction constraints. Automated introduction of microfluidic droplets has been demonstrated to overcome this limitation. Most devices for coupling microfluidic droplets to microchip electrophoresis are only compatible with free-solution separations. Here, we present a device that is compatible with coupling droplets to gel and free-solution electrophoresis. In this device, automated sample introduction is based on a novel mechanism of carrier phase separation using the difference in density of the carrier phase and the running buffer. This device is demonstrated for microchip gel electrophoresis and free-solution electrophoresis separations of protein-protein interaction and enzyme samples, respectively. Throughputs of about 10 s per sample are achieved and over 1000 separations are demonstrated without reconditioning of the device. Graphical abstract.


Assuntos
Eletroforese em Microchip/instrumentação , Mapeamento de Interação de Proteínas/instrumentação , Biocatálise , Desenho de Equipamento , Géis/química , Mapas de Interação de Proteínas , Proteínas/metabolismo
9.
Food Chem ; 295: 320-326, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31174764

RESUMO

This research focused on the effects of l-arginine (l-Arg) and l-histidine (l-His) on the heat-induced aggregation of fish myosin. l-Arg/l-His increased the pH of the myosin solution from 6.82 to 8.74 and 7.24, respectively, and decreased the turbidity, aggregate size, shear modulus, and breaking force. The incorporation of l-Arg/l-His decreased the surface hydrophobicity during setting, but increased it during the two-step heating. The heat-induced aggregation of myosin was suppressed by both amino acids, with the inhibitory effect being greater for l-Arg than l-His. On one hand, the change in the pH played a critical role in suppressing the heat-induced aggregation of myosin. On the other hand, the characteristics of l-Arg/l-His themselves, such as net charges and particular R-groups, were another main contributor to aggregation suppression. Particularly, l-Arg/l-His could interact with exposed aromatic residues of myosin, and the interactions may dominate and overwhelm the burial of aromatic residues during two-step heating.


Assuntos
Arginina/química , Proteínas de Peixes da Dieta/química , Histidina/química , Miosinas/química , Animais , Cyprinidae , Proteínas de Peixes da Dieta/metabolismo , Géis/química , Temperatura Alta , Interações Hidrofóbicas e Hidrofílicas , Miosinas/metabolismo
10.
J Photochem Photobiol B ; 197: 111528, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31226526

RESUMO

Root conditioners are used to promote root surface biomodification to increase the success rate of root coverage. Citric acid and tetracycline are commonly used. There is recent indication for using antimicrobial photodynamic therapy (aPDT) with this purpose. The aim of this study is to evaluate the effects of citric acid/tetracycline gel and aPDT in root coverage of gingival recessions using subepithelial connective tissue graft. This parallel, double-blinded clinical trial enrolled 17 patients (60 recession defects; 20/group). Experimental groups were: Control group (SRP) - scaling and root planing only; Citric acid/tetracycline gel (CAT) group - SRP plus citric acid/tetracycline gel; aPDT - SRP, toluidine blue O (100 µl/ml) and red laser. At baseline and after 3, 6 and 12 months, the clinical parameters were evaluated: recession depth (RD), percentage of root coverage (%RC), keratinized tissue width (KTW), soft tissue thickness (STT), probing depth (PD), clinical attachment level (CAL), dentin hypersensitivity (HYPER) and esthetic perception by patient (EST). CAT group presented reduction in PD, CAL, RD, increase in KTW and STT, higher %RC (81.6%) and better esthetic in relation to SRP group (p < .05). aPDT treatment promoted CAL reduction, gain of KTW and STT and higher %RC (82.1%) in relation to SRP (57.7%) (p < .05). There was a reduction in dentin sensitivity in all groups. Complete root coverage was higher for CAT group (65%) and aPDT group (70%) in relation to SRP (30%) (p < .05). Root conditioning, with citric acid/tetracycline gel and aPDT, promotes better long-term clinical outcomes and root coverage after SCTG procedures.


Assuntos
Ácido Cítrico/química , Gengiva/transplante , Retração Gengival/terapia , Lasers , Tetraciclina/química , Adulto , Anti-Infecciosos/química , Anti-Infecciosos/uso terapêutico , Sensibilidade da Dentina/patologia , Método Duplo-Cego , Feminino , Géis/química , Gengiva/patologia , Retração Gengival/patologia , Regeneração Tecidual Guiada Periodontal , Humanos , Masculino , Pessoa de Meia-Idade , Fotoquimioterapia , Aplainamento Radicular , Tetraciclina/uso terapêutico , Raiz Dentária/cirurgia , Resultado do Tratamento , Adulto Jovem
11.
Food Chem ; 296: 100-108, 2019 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-31202293

RESUMO

The effects of the addition of edible gums (xanthan gum (XG), flaxseed gum (FG), konjac glucomannan (KGM) or tamarind seed gum (TSG)) on texture, gelatinisation and retrogradation of selected starches were investigated. XG and KGM significantly (p < 0.05) reduced syneresis of rich starch gels, from 62.5% to 13.1% and 62.5% to 21.2%, respectively. Moreover, the addition of gums resulted in softer binary gels, the hardness of lotus root starch was reduced from 39.07 to 14.08 g with the increase in XG content. Additionally, FG and TSG significantly increased the peak viscosity of mung bean starch (MBS) gels from 4372 to 10,285 cp. This facilitated the use of MBS gels as thickeners in foods. Binary gels improved the heat stability of starch gels, thus, widening its application in the preparation of baked foods. Binary gels could be used as additives in food production to improve the overall quality of foods.


Assuntos
Géis/química , Polissacarídeos Bacterianos/química , Amido/química , Gelatina/química , Gelatina/metabolismo , Lotus/metabolismo , Mananas , Sementes/metabolismo , Paladar , Temperatura Ambiente , Viscosidade
12.
Food Chem ; 297: 124941, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31253326

RESUMO

The effect of a hydroxyl radical generating system (HRGS), which contained FeCl3, sodium ascorbate, and different concentrations of H2O2, on the physiochemical properties of myofibrillar protein (MP) from squid mantles, has been investigated. The effect of different exposure times to HRGS was also considered. Compared to non-oxidized MP, a significant (p < 0.05) increase in carbonyl content (more than 50% of its original content) and protein solubility, as well as in surface hydrophobicity, was observed in the oxidative MP. With different treatment times, a sharp decrease (p < 0.05) in sulfhydryl content was detected. In addition, hydroxyl radical treatment significantly reduced the MP gel's texture properties, whiteness and water holding capacity, especially at higher concentrations of H2O2. This observation could be attributed to extensive disorderly and less compact structure of MP gels. The results demonstrate the negative effect of HRGS on the structural and functional properties of MP from squid mantles.


Assuntos
Decapodiformes/metabolismo , Proteínas de Frutos do Mar/química , Animais , Ácido Ascórbico/química , Géis/química , Interações Hidrofóbicas e Hidrofílicas , Radical Hidroxila/química , Oxirredução , Reologia , Proteínas de Frutos do Mar/metabolismo , Solubilidade , Compostos de Sulfidrila/análise , Água/química
13.
Food Chem ; 297: 124939, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31253337

RESUMO

Effects of the brine solution with different NaOH concentrations on the physicochemical properties, intermolecular forces, and gel properties of duck egg whites were studied. The free alkalinity, salt content and surface hydrophobicity of egg whites increased as the pickling time and NaOH concentration increased. The primary intermolecular forces (disulfide bonds and hydrophobic interactions) in the alkali egg white gels were increased firstly and then decreased, resulting from the fact that the proteins were degraded under strong alkali conditions during the late stage of the pickling process. Changes of hardness and springiness of egg white gels were closely related with the interactions of the protein molecules. Thereinto, the change tendency of springiness was in accordance with the changes of hydrogen bond of egg white gels. The colour of the egg white gels obtained from alkali treatment changed from white to amber during pickling.


Assuntos
Clara de Ovo/química , Géis/química , Cloreto de Sódio/química , Hidróxido de Sódio/química , Animais , Patos , Eletroforese em Gel de Poliacrilamida , Ligações de Hidrogênio , Interações Hidrofóbicas e Hidrofílicas , Temperatura Ambiente
14.
Anal Chim Acta ; 1072: 54-60, 2019 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-31146865

RESUMO

In this work, we reported a novel electrochemical sensor for enantiorecognition of electrochemically inactive aspartic acid (Asp) enantiomers. By combining sol-gel processing with molecular imprinting technology, an enantioselective interface of molecularly imprinted sol-gel (MIS) films with imprinted cavities was prepared on the surface of a glassy carbon electrode (GCE). In order to obtain the electrochemical responses of electrochemically inactive Asp, the ternary derivative of L-aspartic, (l-aspartic acid)Cu2+(N-carbobenzoxy-l-aspartic acid), was used as the template for fabrication of MIS. The stripping currents of target molecules could be detected by square-wave stripping voltammetry due to the reduction of cupric ion on the modified electrode. The resulted sensor showed good adsorbability to L-Asp derivative, and the recognition efficiency was obtained as 2.1. Meanwhile, the L-Asp was quantitatively determined by the MIS sensor. As a result, the proposed electrochemical sensor could be regarded as a potential platform for enantiorecognition of electrochemically inactive chiral compounds.


Assuntos
Ácido Aspártico/análise , Complexos de Coordenação/química , Cobre/química , Técnicas Eletroquímicas , Impressão Molecular , Géis/química , Conformação Molecular , Tamanho da Partícula , Estereoisomerismo , Propriedades de Superfície
15.
Food Chem ; 293: 529-536, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31151644

RESUMO

The effect of glucose oxidase (GOx) catalytic oxidation on the efficacy of gallic acid (GA) to modify the chemical structure and gelling behavior of myofibrillar protein (MP) was investigated. In contrast to non-oxidized MP samples where GA induced very little changes, GA (0, 6, 30, and 60 µmol/g MP) under GOx treatment promoted sulfhydryl and amine loss (up to 58% and 49%, respectively). The attenuation of intrinsic tryptophan fluorescence in the GA/GOx-treated MP corroborated the finding. The gelling capacity of MP, corresponding to disulfide and non-disulfide bond formation in protein aggregates, was markedly enhanced by 60 µmol GA under GOx, up to 86% in gel storage modulus G' and 53% in gel strength. The GOx-aided GA modification of MP could be a potential ingredient strategy in meat processing to promote textural attributes of cooked products.


Assuntos
Ácido Gálico/química , Géis/química , Glucose Oxidase/metabolismo , Proteínas Musculares/química , Aminas/química , Aminas/metabolismo , Animais , Ácido Gálico/metabolismo , Carne/análise , Microscopia Eletrônica de Varredura , Proteínas Musculares/metabolismo , Oxirredução , Reologia , Compostos de Sulfidrila/química , Compostos de Sulfidrila/metabolismo
16.
Food Chem ; 293: 226-232, 2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31151605

RESUMO

Iprodione is a fungicide widely used in viticulture in most agricultural countries. It was banned recently in the European community because of its carcinogenic and endocrine disrupting characters. In this work, a cheap analytical method able to monitor iprodione in a white wine was developed. Molecularly imprinted sol-gel polymers (MIS) specific to iprodione and using green solvents were synthesized. An experimental design having the following factors (solvent volume and crosslinker quantity) was used to prepare an optimal MIS. In terms of selectivity, the optimal MIS showed the best partition coefficient towards iprodione in a white wine containing four other competing fungicides (procymidone, pyrimethanil, azoxystrobin and iprovalicarb). A solid phase extraction method using the optimal MIS was optimized and applied to analyse iprodione in a white wine. Low detection and quantification limits were reached 11.7 and 39.1 µg/L respectively.


Assuntos
Aminoimidazol Carboxamida/análogos & derivados , Fungicidas Industriais/análise , Hidantoínas/análise , Impressão Molecular , Polímeros/química , Solventes/química , Vinho/análise , Aminoimidazol Carboxamida/análise , Aminoimidazol Carboxamida/isolamento & purificação , Cromatografia Líquida de Alta Pressão , Fungicidas Industriais/isolamento & purificação , Géis/química , Química Verde , Hidantoínas/isolamento & purificação , Extração em Fase Sólida/métodos
17.
Food Chem ; 297: 125027, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31253341

RESUMO

The structure and the cation-exchange functional groups of hybrid silica materials were evaluated for the effective detoxification of hydroalcoholic solutions containing eight toxic biogenic amines (BA) usually found in fermented beverages. Results show the effectiveness of the removal is related to the number of amino functions in the extracted molecule, retention by the solid being more effective in the case of multiple amino groups, since retention is stabilized through interaction with the material surface at several points. BA with one amino function (isoamylamine, tyramine, ß-phenylethylamine), in general, showed a weak retention by the solids. For BA with more than two amine groups (spermine, spermidine), the removal rate was close to 100% for all studied materials. For histamine, cadaverine and putrescine, the removal percentages were higher with a lamellar structured sulfonic acid functionalized material and with bifunctional materials (SBA-15 type and macroporous) containing sulfonic/phosphonic acid groups obtained by co-condensation sol-gel route.


Assuntos
Aminas Biogênicas/química , Dióxido de Silício/química , Adsorção , Aminas/química , Aminas Biogênicas/análise , Cadaverina/química , Cromatografia Líquida de Alta Pressão , Géis/química , Histamina/química , Espectrometria de Massas , Porosidade , Putrescina/química , Espermidina/química , Espermina/química , Ácidos Sulfônicos/química , Propriedades de Superfície , Tiramina/química
18.
AAPS PharmSciTech ; 20(6): 228, 2019 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-31227940

RESUMO

In order to obtain sustained release of biodegradable microspheres, the purpose of this study was to design and characterize an injectable octreotide microsphere-gel composite system. The octreotide microspheres were prepared by phase separation method, which used PLGA as a carrier material, dimethyl silicone oil as a phase separation reagent, and n-heptane-Span 80 as a hardener. In addition, we used poloxamer 407 (PL 407) and poloxamer 188 (PL 188) as the thermosensitive gel matrix material. The composite system was obtained by scattering octreotide microspheres in a poloxamer gel. In vitro data showed that the release time of the composite system could last for about 50 days. Because of the blocking and control actions of the poloxamer gel, the initial burst release was significantly reduced and the plateau phase was eliminated. Pharmacokinetic data showed that the burst release of the composite system was significantly less than that of the microspheres, i.e., Cmax1 was reduced by about half. From day 2 to day 50, higher plasma concentration levels and more stable drug release behavior were exhibited. In addition, the good biocompatibility of the composite system in vivo was also demonstrated by hematoxylin-eosin (HE) staining. Therefore, the octreotide microsphere-gel composite system will be a new direction for hydrophilic polypeptide/protein-loaded sustained release dosage forms with high pharmacological activity.


Assuntos
Géis/química , Microesferas , Octreotida/administração & dosagem , Copolímero de Ácido Poliláctico e Ácido Poliglicólico/administração & dosagem , Animais , Liberação Controlada de Fármacos , Masculino , Octreotida/química , Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química , Ratos , Ratos Sprague-Dawley
19.
Chem Commun (Camb) ; 55(53): 7683-7686, 2019 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-31204739

RESUMO

An easy access to topical gels (both hydro- and organogels) derived from an anti-cancer prodrug namely 5-fluorouracil acetic acid (5-FuA) achieved by exploiting a simple salt formation strategy is reported for the first time. Nearly 85% of the salts synthesized were gelators. Single crystal structures of some of the gelator salts revealed an intriguing hydrogen bonding network including double stranded 1D chains stabilized through uracil-uracil complementary interactions and the crystal structures of the gelator salts corroborated well with the hypothesis based on which the gelators were designed. Studies indicated that both the hydrogel and the methyl salicylate gel of the gelator salt FuA-15 were suitable for self-drug-delivery application.


Assuntos
Ácido Acético/farmacologia , Antineoplásicos/farmacologia , Sistemas de Liberação de Medicamentos , Fluoruracila/farmacologia , Pró-Fármacos/farmacologia , Ácido Acético/síntese química , Ácido Acético/química , Antineoplásicos/síntese química , Antineoplásicos/química , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Fluoruracila/síntese química , Fluoruracila/química , Géis/síntese química , Géis/química , Géis/farmacologia , Humanos , Ligações de Hidrogênio , Estrutura Molecular , Tamanho da Partícula , Pró-Fármacos/síntese química , Pró-Fármacos/química , Relação Estrutura-Atividade , Propriedades de Superfície
20.
Molecules ; 24(9)2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-31083427

RESUMO

Aerogels are a special class of nanostructured materials with very high porosity and tunable physicochemical properties. Although a few types of aerogels have already reached the market in construction materials, textiles and aerospace engineering, the full potential of aerogels is still to be assessed for other technology sectors. Based on current efforts to address the material supply chain by a circular economy approach and longevity as well as quality of life with biotechnological methods, environmental and life science applications are two emerging market opportunities where the use of aerogels needs to be further explored and evaluated in a multidisciplinary approach. In this opinion paper, the relevance of the topic is put into context and the corresponding current research efforts on aerogel technology are outlined. Furthermore, key challenges to be solved in order to create materials by design, reproducible process technology and society-centered solutions specifically for the two abovementioned technology sectors are analyzed. Overall, advances in aerogel technology can yield innovative and integrated solutions for environmental and life sciences which in turn can help improve both the welfare of population and to move towards cleaner and smarter supply chain solutions.


Assuntos
Géis/química , Nanoestruturas/química , Porosidade
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