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1.
Chemosphere ; 240: 124918, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31563717

RESUMO

Bisphenol A (BPA) is one of the largest amounts of chemicals in daily life and source of polycarbonate plastics, epoxy resins, medical equipment, plastic consumer products. Recent studies reported that the effects of BPA on human health in the thyroid hormone. Therefore, this study aimed to indicate the association between urinary BPA concentration and thyroid function in total triiodothyronine (T3), thyroxine (T4), thyroidal stimulating hormone (TSH) and stratified the population by body mass index (BMI). This study was performed on 6478 adults aged 19 years and older based on the Second Korean National Environmental Health Survey (KoNEHS, 2012-2014). We measured BPA in urine and total T3, T4 and TSH in serum from the 2nd KoNEHS study. The multiple regression analysis was performed to assess the association of urinary BPA concentrations with thyroid hormone after BMI stratification. Urinary BPA associated with thyroid hormone. Especially, BPA is related to T3 (-0.627) in all group, and T4 (-0.060, -0.098) in all group and the group of BMI 25.0kg/m2 or more negatively. When stratified by BPA, T3 and T4 were significantly decreased with the high BPA exposure compared with the low BPA exposure for BMI more than 25.0kg/m2 (adjusted ß = -3.402, 95% CI: 4.942, -1.862, adjusted ß = -0.209, 95% CI: 0.328, -0.090). However, no obvious associations were found between BPA concentration and TSH. The results of urinary BPA decrease with T3 and T4 levels increase in the higher BMI group is a new finding which does not exist in recent studies of Korea.


Assuntos
Compostos Benzidrílicos/urina , Poluentes Ambientais/urina , Fenóis/urina , Glândula Tireoide/fisiologia , Hormônios Tireóideos/sangue , Adulto , Idoso , Compostos Benzidrílicos/toxicidade , Índice de Massa Corporal , Estudos Transversais , Saúde Ambiental , Poluentes Ambientais/toxicidade , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Pessoa de Meia-Idade , Fenóis/toxicidade , República da Coreia , Testes de Função Tireóidea , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue , Adulto Jovem
2.
Niger J Clin Pract ; 22(10): 1417-1422, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31607733

RESUMO

Background: There is a mutual dynamic interaction between thyroid volume (TV), insulin-like growth factor-1 (IGF-1), and body mass index (BMI). These covariates undergo a change with the transition into puberty. The heterogeneity of the variates and study populations complicate the evaluation of the role of pure pubertal effect. Objective: The purpose of this study was to investigate the effect of puberty on IGF-1 and TV in a predetermined homogenous population such as obese children. Subjects and Methods: Three hundred and eighty children (202 girls and 178 boys) aged between 6 and 18 were enrolled in this prospective study. The children were assigned to two groups according to their pubertal status, i.e., prepubertal (n = 169) and postpubertal (n = 211). According to age and sex, the obese group (n = 222) was made up of children at and above the 95th percentile, and the control group (n = 158) of children under the 85th percentile. The following parameters were evaluated in all children: BMI, pubertal status, TV, and serum IGF-1, IGFBP-3, and IGF-1:IGFBP-3 molar ratio. Results: In comparison to the prepubertal obese group, the obese group at Tanner stage 2 had a larger mean TV (P = 0.008) and higher IGF-1 level (P = 0.033). There was a positive correlation between IGF-1 and TV both in the prepubertal and pubertal group (r169= 0.369, P = 0.001; r211= 0.316, P = 0.004, respectively), whereas there was no correlation between IGF-1 and BMI (r169= 0.99, P = 0.092; r211= 0.094, P = 0.088, respectively). Conclusion: This study showed that the TV and serum IGF-1 levels were increased in obese children in the early stage of puberty and that there was a positive correlation between these two variables in all children, which shows the specific effect of the early stage of puberty on the increase in TV and IGF-1 levels and suggests that increased TV is associated with the increase in IGF-1 levels in a homogenous group such as obese children.


Assuntos
Fator de Crescimento Insulin-Like I/metabolismo , Obesidade/sangue , Obesidade/fisiopatologia , Puberdade/fisiologia , Maturidade Sexual , Glândula Tireoide/fisiologia , Adolescente , Índice de Massa Corporal , Criança , Pré-Escolar , Feminino , Humanos , Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina , Masculino , Estudos Prospectivos , Proteínas Recombinantes
3.
Clin Biochem ; 74: 19-23, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31499031

RESUMO

BACKGROUND: This 4-year retrospective cohort study aimed to establish reference intervals for free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) in premature infants using the Beckman Coulter Unicel DxI 800 automated immunoassay system. METHODS: Study subjects included 605 preterm infants with a gestational age of 26-36 weeks (corrected: 29-38 weeks). Pearson correlation was used to evaluate the association between hormone levels and gestational and corrected gestational ages. A nonparametric method was used to establish reference intervals based on corrected gestational age. RESULTS: FT3 and FT4 levels were positively correlated with gestational and corrected gestational ages, respectively. TSH levels were slightly negatively correlated with gestational and corrected gestational ages. FT3 significantly differed according to corrected gestational age (29-33 weeks vs 34-38 weeks); however, the difference was smaller than the reference change value (RCV) for the FT3 test. Thus, we combined the FT3 reference intervals into a single reference interval: 2.65-4.93 pmol/L (29-38 weeks). The reference intervals of FT4 and TSH were 11.20-24.97 pmol/L (29-38 weeks) and 1.01-10.14 mIU/L (29-38 weeks), respectively. CONCLUSIONS: Unlike those of full-term infants or adults, the reference intervals established in this study are applicable in premature infants. These results highlight the importance and complexity of establishing instrument-specific thyroid hormone reference intervals for preterm infants.


Assuntos
Idade Gestacional , Imunoensaio/métodos , Recém-Nascido Prematuro/fisiologia , Testes de Função Tireóidea/métodos , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangue , Feminino , Humanos , Recém-Nascido , Modelos Lineares , Masculino , Valores de Referência , Estudos Retrospectivos , Glândula Tireoide/fisiologia
4.
Sci Total Environ ; 697: 134140, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31476497

RESUMO

Organotin compounds are the ubiquitous environmental pollutants due to their wide industrial and agricultural applications and unexpected releasing into the environment, which show characteristic of endocrine disruptors to interfere with the synthesis, receptor binding or action of endogenous-hormones. Organotin pesticides (OTPs) are used in agriculture and may impact endocrine functions on organisms. Thyroid hormones (THs) play fundamental roles in regulating the basal metabolism and energy balance, while thyroid function can be impaired by environmental contaminants. Therefore, it is crucial to clarify the effects and mechanisms of OTPs on hypothalamus-pituitary-thyroid (HPT) axis. In this study, Xenopus laevis tadpoles at stage 51 were exposed to fentin hydroxide and fenbutatin oxide (0.04, 0.20 and 1.00 µg·L-1) for 21 days. It was found that both compounds caused inhibitory effects on metamorphic development of tadpoles (e.g., significant decrease in hindlimb length and retarding development). Triiodothyronine (T3) significantly decreased in tadpoles exposed to 0.20 µg/L and 1.00 µg/L of the two OTPs for 14 days or 21 days. The expressions of TH responsive genes trß, bteb and dio2 were down-regulated, while tshß and slc5a5 were up-regulated. Surface plasmon resonance (SPR) binding assays showed that fentin hydroxide had a moderate affinity to recombinant human thyroid hormone receptor ß but fenbutatin oxide did not have. Result of the SPR assay was highly consistent with the luciferase reporter gene assays that fentin hydroxide suppressed the relative luciferase activity in the presence of T3 while fenbutatin oxide did not, demonstrating fentin hydroxide but not fenbutatin oxide displayed an antagonistic activity against T3-TR complex mediated transcriptional activation. Overall, the findings elucidated the mechanisms induced by OTPs along HPT axis. These results highlighted the adverse influences of organotin pesticides on thyroid hormone- dependent development in vertebrates and the need for more comprehensive investigations of their potential ecological risks.


Assuntos
Disruptores Endócrinos/toxicidade , Metamorfose Biológica/efeitos dos fármacos , Compostos Orgânicos de Estanho/toxicidade , Praguicidas/toxicidade , Glândula Tireoide/efeitos dos fármacos , Animais , Larva , Glândula Tireoide/fisiologia , Hormônios Tireóideos , Poluentes Químicos da Água/toxicidade , Xenopus laevis
5.
Orv Hetil ; 160(35): 1376-1379, 2019 Sep.
Artigo em Húngaro | MEDLINE | ID: mdl-31448641

RESUMO

Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35-4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639-2.338] vs. 0.920 [0.508-1.826] ng/ml, p<0.016). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient's thyroid status. Orv Hetil. 2019; 160(35): 1376-1379.


Assuntos
Antígeno Prostático Específico/sangue , Doenças da Glândula Tireoide/sangue , Glândula Tireoide/fisiologia , Tireotropina/sangue , Adulto , Fatores Etários , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Estudos Retrospectivos , Doenças da Glândula Tireoide/diagnóstico
7.
Biol Aujourdhui ; 213(1-2): 17-26, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31274099

RESUMO

An increase in the prevalence of many diseases affecting the nervous system in both children and adults has been reported. Some of these diseases are related to endocrine dysfunction, notably of the thyroid axis. Examples in children are attention deficit/hyperactivity disorders and Autism Spectrum Disorders, diagnosed but most often affecting the whole life, and multiple sclerosis or Alzheimer's disease in adults. It is becoming increasingly clear that embryonic exposure to thyroid hormone disruptors can lead to short- and long-term consequences, that often escape conventional neonatal diagnosis. Endocrine disruptors comprise a wide range of molecules, plasticizers, some pesticides, surfactants, flame-retardants, etc., many of which can interfere with thyroid hormone synthesis or their actions. We here report briefly the history of endocrine disruptors, their properties and the consequences on neuronal development of embryonic exposure to some of them.


Assuntos
Comportamento/efeitos dos fármacos , Encéfalo/efeitos dos fármacos , Encéfalo/embriologia , Disruptores Endócrinos/farmacologia , Glândula Tireoide/efeitos dos fármacos , Adulto , Animais , Antitireóideos/farmacologia , Comportamento/fisiologia , Encéfalo/crescimento & desenvolvimento , Criança , Humanos , Glândula Tireoide/fisiologia , Hormônios Tireóideos/farmacologia
10.
J Diabetes Res ; 2019: 5904264, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31360730

RESUMO

Objective: This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone. Methods: The subjects of the study were healthy subjects who underwent physical examination at the Sir Run Run Shaw Hospital affiliated to the Medical College of Zhejiang University from January 2016 to December 2018. Demographic information and medical history of all subjects were recorded through an electronic health system. Serum uric acid (SUA) was grouped by quartiles. Statistical analyses were performed with R version 3.5.1. Results: A total of 48,526 subjects were included in the analysis. Gender ratio, age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, FBG, HbA1c, TG, HDL-C, ALT, AST, FT3, FT4, and TSH were significantly different among the uric acid groups. The regression coefficients of SUA in the TSH, FT3, and FT4 regression models were B = 1.000 (95% CI 1.000-1.000, p = 0.009), B = 0.999 (95% CI 0.999-0.999, p < 0.001), and B = 1.001 (95% CI 1.001-1.001, p < 0.001), respectively. There was a significant dose-dependent relationship between FT4, FT3, and SUA gradient. Conclusions: Under normal thyroid function, there were significant differences in TSH, FT3, and FT4 between groups with different uric acid levels. Uric acid levels were linearly correlated with FT3 and FT4, but not with TSH.


Assuntos
Saúde , Glândula Tireoide/fisiologia , Hormônios Tireóideos/sangue , Ácido Úrico/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Saúde/estatística & dados numéricos , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Estudos Retrospectivos , Testes de Função Tireóidea/normas , Adulto Jovem
11.
Endocrinology ; 160(8): 1771-1785, 2019 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-31135896

RESUMO

The CLARITY-BPA experiment, a large collaboration between the National Institute of Environmental Health Sciences, the National Toxicology Program, and the US Food and Drug Administration, is designed to test the effects of bisphenol A (BPA) on a variety of endocrine systems and end points. The specific aim of this subproject was to test the effect of BPA exposure on thyroid functions and thyroid hormone action in the developing brain. Timed-pregnant National Center for Toxicological Research Sprague-Dawley rats (strain code 23) were dosed by gavage with vehicle control (0.3% carboxymethylcellulose) or one of five doses of BPA [2.5, 25, 250, 2500, or 25,000 µg/kg body weight (bw) per day] or ethinyl estradiol (EE) at 0.05 or 0.50 µg/kg bw/d (n = 8 for each group) beginning on gestational day 6. Beginning on postnatal day (PND) 1 (day of birth is PND 0), the pups were directly gavaged with the same dose of vehicle, BPA, or EE. We also obtained a group of animals treated with 3 ppm propylthiouracil in the drinking water and an equal number of concordant controls. Neither BPA nor EE affected serum thyroid hormones or thyroid hormone‒sensitive end points in the developing brain at PND 15. In contrast, propylthiouracil (PTU) reduced serum T4 to the expected degree (80% reduction) and elevated serum TSH. Few effects of PTU were observed in the male brain and none in the female brain. As a result, it is difficult to interpret the negative effects of BPA on the thyroid in this rat strain because the thyroid system appears to respond differently from that of other rat strains.


Assuntos
Compostos Benzidrílicos/toxicidade , Encéfalo/efeitos dos fármacos , Feto/efeitos dos fármacos , Fenóis/toxicidade , Propiltiouracila/toxicidade , Glândula Tireoide/efeitos dos fármacos , Animais , Etinilestradiol/farmacologia , Feminino , Masculino , Ratos , Ratos Sprague-Dawley , Glândula Tireoide/fisiologia , Tireotropina/sangue
12.
Int J Vitam Nutr Res ; 89(1-2): 80-88, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30982439

RESUMO

Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.


Assuntos
Glândula Tireoide/fisiologia , Hormônios Tireóideos/metabolismo , Hormônio Liberador de Tireotropina/fisiologia , Tireotropina , Zinco , Hormônios Tireóideos/química , Hormônio Liberador de Tireotropina/química
13.
Artigo em Inglês | MEDLINE | ID: mdl-30986998

RESUMO

Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such as organochlorines and pesticides, are able to disrupt thyroid function. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid, transport proteins, replace thyroxin, and disrupt thyroid function as phthalates and bisphenolates do, highly mimicking thyroid hormones. A better knowledge of environmental risks represents a very important tool for cancer prevention through true risks prevention and management. This approach is very important because of the epigenetic origin's theory of cancer. Therefore, the aim of this review was study the association between environmental agents and thyroid cancer promotion.


Assuntos
Carcinógenos/toxicidade , Poluentes Ambientais/toxicidade , Humanos , Fatores de Risco , Glândula Tireoide/efeitos dos fármacos , Glândula Tireoide/fisiologia
14.
Acta Med Okayama ; 73(2): 127-133, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31015747

RESUMO

We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects' height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects' intake of energy and nutrients based on meals provided at the subjects' dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol were measured. Most of the subjects (81.3%) were underweight (body mass index <18.5). The thyroid hormone free T3 value was decreased, but TSH was not increased and was similar to that observed in individuals with anorexia nervosa. In our subjects, thyroid hormone was associated with BMD and nutritional intake. To improve the menstruation abnormality of female athletes and to increase their bone density, the athletes' weight should be managed by proper nutrient intake and the maintenance of their thyroid function.


Assuntos
Densidade Óssea/fisiologia , Ingestão de Energia/fisiologia , Corrida/fisiologia , Glândula Tireoide/fisiologia , Adolescente , Amenorreia/etiologia , Índice de Massa Corporal , Feminino , Humanos , Tireotropina/sangue
15.
Appl Microbiol Biotechnol ; 103(8): 3537-3547, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30850874

RESUMO

Iodine is an important trace element involved in thyroid hormone biosynthesis, while diet-induced obesity is reported to disturb the trace element metabolic balance. Herein, we studied the host-specific responses involved in modulating thyroid function and gut microbiota in obese mice after the iodine treatment and analyzed the possible causes for these responses. Obesity in the mice was induced by a high-fat diet, and the obese and normal mice were treated with the same iodine dosage (18 µg/kg/day) continuously for 8 weeks. Iodine treatment in the obese mice showed a weight-reducing effect, increased the thyroid hormone concentrations, altered the transcriptions of genes involved in thyroid hormone biosynthesis, and modulated the gut microbiota with an increased abundance of pathogenic bacteria and decreased the proportion of beneficial bacteria. However, completely different or even opposite response profiles were observed in the normal hosts. Our work indicated that obesity may exacerbate the risk of thyroid disease with a relatively safe dose of iodine, and individual differences should be considered with trace element supplementation.


Assuntos
Suplementos Nutricionais , Microbioma Gastrointestinal/fisiologia , Iodo/administração & dosagem , Obesidade/microbiologia , Obesidade/fisiopatologia , Glândula Tireoide/fisiologia , Animais , Dieta Hiperlipídica/efeitos adversos , Fezes/química , Fezes/microbiologia , Feminino , Microbioma Gastrointestinal/efeitos dos fármacos , Iodo/farmacologia , Iodo/urina , Redes e Vias Metabólicas/efeitos dos fármacos , Redes e Vias Metabólicas/genética , Camundongos Endogâmicos ICR , Obesidade/etiologia , Obesidade/patologia , Glândula Tireoide/efeitos dos fármacos , Hormônios Tireóideos/sangue , Hormônios Tireóideos/metabolismo
16.
Ann Intern Med ; 170(7): 453-464, 2019 04 02.
Artigo em Inglês | MEDLINE | ID: mdl-30856652

RESUMO

Background: Hashimoto disease is a chronic autoimmune thyroiditis. Despite adequate hormone substitution, some patients have persistent symptoms that may be the result of immunologic pathophysiology. Objective: To determine whether thyroidectomy improves symptoms in patients with Hashimoto thyroiditis who still have symptoms despite having normal thyroid gland function while receiving medical therapy. Design: Randomized trial. (ClinicalTrials.gov: NCT02319538). Setting: Secondary care hospital in Norway. Patients: 150 patients aged 18 to 79 years with persistent Hashimoto-related symptoms despite euthyroid status while receiving hormone replacement therapy and with serum antithyroid peroxidase (anti-TPO) antibody titers greater than 1000 IU/mL. Intervention: Total thyroidectomy or medical management with hormone substitution to secure euthyroid status in both groups. Measurements: The primary outcome was general health score on the Short Form-36 Health Survey (SF-36) at 18 months. Secondary outcomes were adverse effects of surgery, the other 7 SF-36 subscores, fatigue questionnaire scores, and serum anti-TPO antibody titers at 6, 12, and 18 months. Results: During follow-up, only the surgical group demonstrated improvement: Mean general health score increased from 38 to 64 points, for a between-group difference of 29 points (95% CI, 22 to 35 points) at 18 months. Fatigue score decreased from 23 to 14 points, for a between-group difference of 9.3 points (CI, 7.4 to 11.2 points). Chronic fatigue frequency decreased from 82% to 35%, for a between-group difference of 39 percentage points (CI, 23 to 53 percentage points). Median serum anti-TPO antibody titers decreased from 2232 to 152 IU/mL, for a between-group difference of 1148 IU/mL (CI, 1080 to 1304 IU/mL). In multivariable regression analyses, the adjusted treatment effects remained similar to the unadjusted effects. Limitation: Results are applicable only to a subgroup of patients with Hashimoto disease, and follow-up was limited to 18 months. Conclusion: Total thyroidectomy improved health-related quality of life and fatigue, whereas medical therapy did not. This improvement, along with concomitant elimination of serum anti-TPO antibodies, may elucidate disease mechanisms. Primary Funding Source: Telemark Hospital.


Assuntos
Doença de Hashimoto/fisiopatologia , Doença de Hashimoto/terapia , Terapia de Reposição Hormonal , Glândula Tireoide/fisiologia , Tireoidectomia , Tiroxina/uso terapêutico , Adolescente , Adulto , Idoso , Anticorpos/sangue , Quimioterapia Combinada , Fadiga/prevenção & controle , Feminino , Seguimentos , Doença de Hashimoto/imunologia , Doença de Hashimoto/cirurgia , Humanos , Iodeto Peroxidase/imunologia , Masculino , Pessoa de Meia-Idade , Medidas de Resultados Relatados pelo Paciente , Complicações Pós-Operatórias , Qualidade de Vida , Tireoidectomia/efeitos adversos , Tri-Iodotironina/uso terapêutico , Adulto Jovem
17.
Zhonghua Liu Xing Bing Xue Za Zhi ; 40(2): 180-185, 2019 Feb 10.
Artigo em Chinês | MEDLINE | ID: mdl-30744269

RESUMO

Objective: To study the dose-response relationship between maternal thyroid hormone levels in the first twenty weeks of pregnancy and the infant physical and neuropsychological development. Methods: In this prospective cohort study, a total of 945 women and their children were included. Maternal serum samples during first half of the pregnancy were collected and analyzed for levels of thyroid hormones by using the electro-chemiluminescence immunoassay. Maternal social demographic information was collected by using the a self-administered questionnaire. Physical measurements of newborns and neuropsychological evaluation of infants were performed by doctors of maternal and child health care. Results: The differences in newborns' birth length and head circumference were significant among the newborns of mothers with different percentiles of maternal serum (thyroid-stimulating hormone, TSH) levels (P<0.05). Newborns with maternal TSH level ≥P(95) or

Assuntos
Peso ao Nascer/fisiologia , Desenvolvimento Infantil/fisiologia , Hormônios Tireóideos/sangue , Tireotropina/sangue , Criança , China , Feminino , Sangue Fetal/metabolismo , Humanos , Lactente , Recém-Nascido/sangue , Gravidez , Efeitos Tardios da Exposição Pré-Natal/sangue , Estudos Prospectivos , Glândula Tireoide/fisiologia , Hormônios Tireóideos/metabolismo
18.
PLoS One ; 14(2): e0212361, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30768635

RESUMO

This paper formulates a support vector machine with quantile hyper-spheres (QHSVM) for pattern classification. The idea of QHSVM is to build two quantile hyper-spheres with the same center for positive or negative training samples. Every quantile hyper-sphere is constructed by using pinball loss instead of hinge loss, which makes the new classification model be insensitive to noise, especially the feature noise around the decision boundary. Moreover, the robustness and generalization of QHSVM are strengthened through maximizing the margin between two quantile hyper-spheres, maximizing the inner-class clustering of samples and optimizing the independent quadratic programming for a target class. Besides that, this paper proposes a novel local center-based density estimation method. Based on it, ρ-QHSVM with surrounding and clustering samples is given. Under the premise of high accuracy, the execution speed of ρ-QHSVM can be adjusted. The experimental results in artificial, benchmark and strip steel surface defects datasets show that the QHSVM model has distinct advantages in accuracy and the ρ-QHSVM model is fit for large-scale datasets.


Assuntos
Máquina de Vetores de Suporte , Mama/fisiologia , Análise por Conglomerados , Feminino , Coração/fisiologia , Humanos , Reconhecimento Automatizado de Padrão , Glândula Tireoide/fisiologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-30760194

RESUMO

OBJECTIVE: The aim of the study was to examine the impact of neonatal acetaminophen (APAP; paracetamol) administrations on the thyroid-liver axis in male Wistar rats. METHODS: APAP (100 or 350mg/kg) was orally administered to neonates from Postnatal Day (PND) 20 to 40. RESULTS: Both APAP doses elicited a substantial increase in serum TSH, albumin, AST, ALT, and ALP values, and a profound decrease in serum FT4 and FT3 values at PND 40 relative to those in the control group. Additionally, the hypothyroid state in both APAP-treated groups may increase the histopathological variations in the neonatal liver, such as destructive degeneration, fibrosis, fatty degeneration, fibroblast proliferation, haemorrhage, oedema, and vacuolar degeneration, at PND 40. Moreover, in the APAP groups, a marked depression was recorded in the t-SH and GSH levels and GPx and CAT activities at PND 40 in the neonatal liver compared to those in the control group. However, the levels of hepatic LPO, H2O2, and NO were increased in both APAP-treated groups at PND 40. All previous alterations were dose- dependent. CONCLUSION: Neonatal APAP caused a hypothyroidism and disturbed hepatic cellular components by increasing prooxidant markers and decreasing antioxidant markers, causing hepatotoxicity. Thus, neonatal administrations of APAP may act as a neonatal thyroid-liver disruptor.


Assuntos
Acetaminofen/efeitos adversos , Overdose de Drogas , Fígado/efeitos dos fármacos , Glândula Tireoide/efeitos dos fármacos , Acetaminofen/administração & dosagem , Acetaminofen/envenenamento , Animais , Animais Recém-Nascidos , Biomarcadores/análise , Biomarcadores/metabolismo , Overdose de Drogas/complicações , Overdose de Drogas/metabolismo , Crescimento e Desenvolvimento/efeitos dos fármacos , Fígado/crescimento & desenvolvimento , Fígado/fisiologia , Masculino , Redes e Vias Metabólicas/efeitos dos fármacos , Ratos , Ratos Wistar , Glândula Tireoide/crescimento & desenvolvimento , Glândula Tireoide/fisiologia
20.
Cell Biol Int ; 43(5): 486-494, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30761678

RESUMO

Hypothyroidism has been linked to infertility, but the mechanisms underlying infertility-related hypothyroidism have yet to be fully elucidated. Therefore, in this study, effects of hypothyroidism on expression of the proteins related to thyroid hormone function in the uterus, which were thought to play a role implantation, including thyroid hormone receptor (TR), thyroid stimulating hormone receptor (TSHR), retinoic acid receptor (RAR) and extracellular kinase (ERK) were identified. Pregnant female rats were rendered hypothyroid by giving methimazole (MMI), orally. Following hypothyroid induction, rats were grouped into control (non-treated) and received subcutaneous thyroxine at 20, 40, and 80 µg/kg/day for five consecutive days. At Day 6, which is the day of implantation (GD 6), rats were sacrificed and the number of embryo implantation site in the uterus was calculated. Then, uterine horns were harvested and expression of the above proteins and their mRNAs were identified by Western blotting and real-time PCR, respectively. In non-treated hypothyroid pregnant rats, the number of embryo implantation sites decreased as compared to euthyroid and hypothyroid rats receiving thyroxine treatment. Similarly, expression of TRα-1, TRß-1, TSHR, ERK1/2 and RAR proteins and mRNA in the uterus of non-treated hypothyroid rats also decreased (P < 0.05 when compared to euthyroid and thyroxine-treated hypothyroid rats). In conclusion, downregulated expression of the thyroid hormone related proteins in the uterus at the day of implantation might result in infertility as reported in hypothyroid condition.


Assuntos
Hipotireoidismo/fisiopatologia , Glândula Tireoide/metabolismo , Hormônios Tireóideos/metabolismo , Animais , Regulação para Baixo/efeitos dos fármacos , Implantação do Embrião , Feminino , Regulação da Expressão Gênica no Desenvolvimento/genética , Hipotireoidismo/complicações , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Metimazol/farmacologia , Gravidez , Ratos , Ratos Sprague-Dawley , Receptores do Ácido Retinoico/análise , Receptores do Ácido Retinoico/metabolismo , Receptores dos Hormônios Tireóideos/análise , Receptores dos Hormônios Tireóideos/metabolismo , Receptores da Tireotropina/análise , Receptores da Tireotropina/metabolismo , Glândula Tireoide/fisiologia , Hormônios Tireóideos/genética , Hormônios Tireóideos/fisiologia , Tiroxina/farmacologia , Útero/metabolismo , Útero/fisiologia
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