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1.
An Bras Dermatol ; 94(6): 751-753, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31789263

RESUMO

Lobular capillary hemangioma or pyogenic granuloma is a benign vascular tumor of the skin or mucous membranes. Most patients present a single lesion. It manifests clinically as an erythematous, friable, and fast-growing tumor. This report details a case with exuberant presentation in a patient with ankylosing spondylitis, using adalimumab. Factors triggering pyogenic granuloma are not well known. They may spontaneously regress, but most require treatment.


Assuntos
Adalimumab/uso terapêutico , Antirreumáticos/uso terapêutico , Granuloma Piogênico/patologia , Dermatopatias/patologia , Espondilite Anquilosante/tratamento farmacológico , Granuloma Piogênico/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Dermatopatias/etiologia , Espondilite Anquilosante/complicações , Fator de Necrose Tumoral alfa/antagonistas & inibidores
2.
An. bras. dermatol ; 94(6): 751-753, Nov.-Dec. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1054883

RESUMO

Abstract Lobular capillary hemangioma or pyogenic granuloma is a benign vascular tumor of the skin or mucous membranes. Most patients present a single lesion. It manifests clinically as an erythematous, friable, and fast-growing tumor. This report details a case with exuberant presentation in a patient with ankylosing spondylitis, using adalimumab. Factors triggering pyogenic granuloma are not well known. They may spontaneously regress, but most require treatment.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Dermatopatias/patologia , Espondilite Anquilosante/tratamento farmacológico , Granuloma Piogênico/patologia , Antirreumáticos/uso terapêutico , Adalimumab/uso terapêutico , Dermatopatias/etiologia , Espondilite Anquilosante/complicações , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Granuloma Piogênico/etiologia
3.
Turk J Med Sci ; 49(5): 1471-1478, 2019 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-31651116

RESUMO

Background/aim: Pyogenic granuloma (PG)-like nodular Kaposi's sarcoma (KS) has been previously demonstrated in several studies. However, to the best of our knowledge, no original study investigating the dermoscopic differential diagnosis of PG and KS exists in the relevant literature. In this study we aimed to identify dermoscopic findings providing useful clues to differential diagnosis between the two entities. Materials and methods: Patients with histopathologically confirmed PG or nodular KS were included in the study. Demographic, clinical, dermoscopic, and histopathological findings of the cases were retrospectively reviewed. Results: The most common finding observed in PG was red structureless areas (80.00%), followed by intersecting thick white lines (56.66%), ulceration (36.66%), and collarette scale (33.33%). The most common findings detected in nodular KS were polychromatic structures (56.66%) and red (46.66%) and white (13.33%) structureless areas, respectively. Conclusion: Intersecting thick white lines seem to be the strongest dermoscopic clue to PG. Striate surface scaling (n = 6) was a novel finding identified for PG. Here we also described a new vascular pattern (widespread vessels composing a network) for nodular KS.


Assuntos
Dermoscopia , Granuloma Piogênico/patologia , Sarcoma de Kaposi/patologia , Neoplasias Cutâneas/patologia , Adolescente , Adulto , Idoso , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
4.
Middle East Afr J Ophthalmol ; 26(3): 138-140, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31619900

RESUMO

PURPOSE: To describe a case series of periocular lobular capillary hemangiomas in adults, outlining characteristic clinical and histopathological patterns. MATERIALS AND METHODS: This was a retrospective case series of 16 patients with review of clinical and histopathological features. RESULTS: Eleven male and five female patients were diagnosed with periocular lobular capillary hemangioma at a median age of 38 years (mean, 41 years; range, 21-71 years). The median tumor basal diameter was 6 mm (mean, 7 mm; range, 3-14 mm) and all were well circumscribed. They arose over the course of weeks to months and developed most commonly in the eyelid region (n = 10), followed by the conjunctiva (n = 6). Excisional biopsy of the lesion was done in all cases. On histopathology, the tumors were composed of repeating units of capillary-sized lobules lined by plump endothelial cells. Lesion recurrence was noted in one case. CONCLUSION: Lobular capillary hemangiomas are common benign vascular tumors of periocular region in adults. Clinicohistopathological features and clinical presentation of these lesions are distinctive. Excisional biopsy was curative with recurrence noted rarely.


Assuntos
Doenças da Túnica Conjuntiva/patologia , Doenças Palpebrais/patologia , Granuloma Piogênico/patologia , Adulto , Idoso , Biópsia , Doenças da Túnica Conjuntiva/cirurgia , Doenças Palpebrais/cirurgia , Feminino , Granuloma Piogênico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Oftalmológicos , Estudos Retrospectivos , Adulto Jovem
5.
J Drugs Dermatol ; 18(10): 1006-1010, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31584779

RESUMO

Pyogenic granuloma (PG) is an acquired vascular growth on the skin and mucous membranes. Even though PG is a benign tumor, treatment is required due to associated risk of ulceration and bleeding, cosmetic concerns, and the low likelihood of spontaneous regression. Treatment entails excisional surgery, cryotherapy, or electrocautery; recurrence however is a major problem. Beta-blockers became an attractive option for the treatment of vascular growths after it got approved for infantile hemangioma. PG was found to express beta adrenergic receptors, similarly to infantile hemangioma. Several publications have reported the use of oral and topical beta blockers such as timolol, propranolol, and betaxolol for the treatment of PG. In this study, we summarized the literature with regards to the effectiveness of topical beta blockers for the treatment of PG, and discussed all published case reports, case series, and open-label single arm trials. J Drugs Dermatol. 2019;18(10):1006-1010.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Granuloma Piogênico/tratamento farmacológico , Dermatopatias/tratamento farmacológico , Administração Cutânea , Administração Oral , Betaxolol/uso terapêutico , Ensaios Clínicos como Assunto , Granuloma Piogênico/patologia , Humanos , Propranolol/uso terapêutico , Receptores Adrenérgicos beta/metabolismo , Recidiva , Pele/patologia , Dermatopatias/patologia , Timolol/uso terapêutico , Resultado do Tratamento
7.
Afr Health Sci ; 19(1): 1687-1694, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31148999

RESUMO

Background: Reactive localized hyperplastic lesions of the oral cavity (RHLs) are relatively common peripheral lesions which present as a range of clinically similar lesions at dental centers. Diagnosis can be challenging if dentists are unfamiliar with their clinicopathological across various populations. Objective: This study reviews the pattern of distribution of RHLs of the oral mucosa in a hospital- the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife. Materials and methods: We reviewed 10 years data from the archives of the Department of Oral Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University, Nigeria. Information on RHLs were extracted and recorded on standardized data forms and analyzed using STATA. Results: The most common lesions were pyogenic granuloma (43.7%) and focal fibrous hyperplasia (39.7%), respectively. RHLs were found to be more frequent in women (66.7%) than men (33.3%). The most common locations of involvement was the gingivae (84.6%), and lesions were more common in the 9-29 year age group and the mean age was 37.7 (±21.1) years. The relationship between age group and reactive lesions was however not statistically significant. Conclusion: The major benefit of this study is an improved knowledge of the frequency and distribution of oral reactive lesions in sub-Saharan Africa which may be highly beneficial when establishing a diagnosis and treatment plan in clinical practice.


Assuntos
Hiperplasia/epidemiologia , Mucosa Bucal/patologia , Boca/patologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Criança , Estudos Transversais , Feminino , Fibroma/epidemiologia , Fibroma/patologia , Fibroma Ossificante/epidemiologia , Fibroma Ossificante/patologia , Granuloma de Células Gigantes/epidemiologia , Granuloma de Células Gigantes/patologia , Granuloma Piogênico/epidemiologia , Granuloma Piogênico/patologia , Humanos , Hiperplasia/classificação , Hiperplasia/patologia , Masculino , Pessoa de Meia-Idade , Nigéria/epidemiologia , Estudos Retrospectivos , Distribuição por Sexo , Adulto Jovem
8.
J Cutan Pathol ; 46(9): 691-697, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31095756

RESUMO

Congenital cutaneous pyogenic granuloma is a rare benign vascular tumor with clinical and histopathological features similar to infantile hemangioma. It usually presents as a red, pedunculated and highly friable papule. On histopathological analysis, one can see a capillary vessel proliferation with lobular pattern and endothelial proliferation. The differential diagnosis is based on negativity of glucose transporter 1 (GLUT1) immunochemistry studies. We report two infants with congenital pyogenic granuloma, one with a unique cutaneous lesion and the other with multiple lesions affecting both skin and mucosal surfaces. These two cases highlight the importance of the differential diagnosis based on the GLUT1 immunochemistry analysis considering the distinct treatments required to these infant vascular tumors.


Assuntos
Transportador de Glucose Tipo 1/metabolismo , Granuloma Piogênico , Proteínas de Neoplasias/metabolismo , Neoplasias Vasculares , Diagnóstico Diferencial , Feminino , Granuloma Piogênico/congênito , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/metabolismo , Granuloma Piogênico/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Neoplasias Vasculares/congênito , Neoplasias Vasculares/diagnóstico , Neoplasias Vasculares/metabolismo , Neoplasias Vasculares/patologia
9.
J Cutan Pathol ; 46(5): 368-371, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30666667

RESUMO

A 52-year-old man presented with a rapidly growing red tumor on the central neckline. It had appeared over a congenital flat and pinkish vascular lesion that involved the shoulder and the upper anterior area of his chest. Intermingled with the pinkish stain, there were also some blue nodules several millimeters in diameter. Histopathologic examination revealed that the full lesion was a mixed venous-capillary malformation. The red tumor was excised and diagnosed as a pyogenic granuloma developing over the venous component of the vascular malformation. To our knowledge, a pyogenic granuloma growing over a venous malformation has not been previously described.


Assuntos
Granuloma Piogênico/patologia , Neoplasias Cutâneas/patologia , Malformações Vasculares/patologia , Granuloma Piogênico/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/metabolismo , Malformações Vasculares/metabolismo
12.
Am J Otolaryngol ; 40(2): 331-333, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30514577

RESUMO

Pyogenic granuloma (PG) may involve gingival mucosa (granuloma gravidarum) in pregnancy but rarely involves the airway. This case report is perhaps the only reported presentation of PG in the larynx causing hemoptysis at a late stage of pregnancy. On laryngoscopic exam, a vascular, right false vocal fold neoplasm was identified with pathological characteristics consistent with PG. Conclusions: Pyogenic granuloma is a relatively common tumor of pregnancy but rarely involves the larynx. In the case of airway involvement during pregnancy, it is best managed in coordination with the high-risk obstetrical team and can be removed safely via standard microsurgical techniques.


Assuntos
Granuloma Piogênico/complicações , Hemoptise/etiologia , Doenças da Laringe/complicações , Complicações na Gravidez , Feminino , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/patologia , Granuloma Piogênico/cirurgia , Humanos , Doenças da Laringe/diagnóstico , Doenças da Laringe/patologia , Doenças da Laringe/cirurgia , Laringoscopia , Lasers de Estado Sólido/uso terapêutico , Microcirurgia/métodos , Equipe de Assistência ao Paciente , Gravidez , Risco , Adulto Jovem
13.
Clin J Gastroenterol ; 12(1): 34-37, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30094594

RESUMO

We describe the case of a previously healthy 8-year-old girl presenting with a 1-year history of iron deficiency anemia. There was no report of hematemesis, abdominal pain or melena. Laboratory work-up excluded iron malabsorption as the underlying cause. Therefore, endoscopic evaluation was performed to exclude gastrointestinal blood loss, which revealed the presence of a 7 mm reddish lesion located within the ampulla of Vater. Capsule endoscopy excluded alternative diagnoses and concomitant lesions. Histopathological examination confirmed the diagnosis of pyogenic granuloma. The young age of the child and the benign nature of this lesion along with the absence of complications favored conservative management. Pyogenic granuloma is a benign vascular lesion that presents as a polypoid red mass. In the gastrointestinal tract, it is a rare condition and occurs more commonly in the elderly. The most common sites are the small intestine, esophagus, and colon, but they can occur throughout the entire gastrointestinal tract with a propensity to bleed that may cause iron deficiency anemia. In pediatric age patients, there are few reports of gastrointestinal pyogenic granulomas, most of which occur in the colon and rectum. Its identification and location in the ampulla of Vater is an exceptional finding.


Assuntos
Ampola Hepatopancreática/patologia , Doenças do Ducto Colédoco/complicações , Doenças do Ducto Colédoco/patologia , Hemorragia Gastrointestinal/etiologia , Granuloma Piogênico/complicações , Granuloma Piogênico/patologia , Idade de Início , Anemia Ferropriva/etiologia , Endoscopia por Cápsula , Criança , Feminino , Humanos
15.
In Vivo ; 33(1): 251-254, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30587632

RESUMO

Pyogenic granuloma (PG) represents a lobular capillary proliferation commonly seen in the skin or oral mucosa. They are rarely reported in the gastrointestinal tract. The mechanism underlying PG pathogenesis is not well understood. Only one case of cutaneous PG associated with cytomegalovirus (CMV) infection has been reported in the English literature. Here, we report such a unique case of PG arising from the small bowel. A 67-year-old male, status post ileocolic resection, presented for follow-up colonoscopy because of Crohn's disease of the terminal ileum and the colon. Colonoscopy revealed inflammation at the ileocolic anastomosis as well as an 8-mm pedunculated lesion with an irregular surface in the neo-terminal ileum. Histological studies of the small bowel mucosa revealed chronic active ileitis with pyloric gland metaplasia, consistent with his clinical history of Crohn's disease. The lesion demonstrated a lobular architecture consisting of clusters of small capillaries of various sizes lined by a single layer of cytologically bland endothelial cells, and accompanied by acute and chronic inflammatory infiltrates and surface erosion/ulceration. The histological features supported the diagnosis of PG. Scattered viral inclusions with positive CMV immunoreactivity were present in the endothelial cells and glandular cells of pyloric gland metaplasia within the PG. To the best of our knowledge, this is the first documented case of PG with local CMV infection in patients with inflammatory bowel disease.


Assuntos
Doença de Crohn/patologia , Infecções por Citomegalovirus/patologia , Granuloma Piogênico/patologia , Doenças Inflamatórias Intestinais/patologia , Idoso , Doença de Crohn/complicações , Doença de Crohn/diagnóstico , Doença de Crohn/virologia , Infecções por Citomegalovirus/complicações , Infecções por Citomegalovirus/diagnóstico , Infecções por Citomegalovirus/virologia , Trato Gastrointestinal/patologia , Trato Gastrointestinal/virologia , Granuloma Piogênico/complicações , Granuloma Piogênico/diagnóstico , Granuloma Piogênico/virologia , Humanos , Íleo/patologia , Íleo/virologia , Doenças Inflamatórias Intestinais/complicações , Doenças Inflamatórias Intestinais/diagnóstico , Doenças Inflamatórias Intestinais/virologia , Mucosa Intestinal/patologia , Mucosa Intestinal/virologia , Intestino Delgado/patologia , Intestino Delgado/virologia , Masculino
19.
Gen Thorac Cardiovasc Surg ; 67(5): 479-482, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-29721848

RESUMO

We herein report an unreported case of pyogenic granuloma that originated in the pulmonary artery. A 38-year-old man was urgently hospitalized with dyspnea and back pain. He had been on hemodialysis for 2 years due to chronic renal failure. We performed contrast-enhanced computed tomography and detected a mass occluding the left main pulmonary artery. The maximum standardized uptake value (SUVmax) of 18F-fluorodeoxy glucose (FDG) in the mass was 4.1. We made a tentative diagnosis of pulmonary artery tumor, and planned an operation. We performed median sternotomy and left anterolateral thoracotomy. As the tumor had not reached the bottom of the left pulmonary artery, we first performed left upper lobectomy. We then performed resection of the pulmonary artery tumor under cardiopulmonary bypass and reconstructed the pulmonary artery with self-pericardium. The pathological diagnosis was pyogenic granuloma. To our knowledge, pyogenic granuloma originating in the pulmonary artery has never been reported before.


Assuntos
Granuloma Piogênico/diagnóstico por imagem , Artéria Pulmonar/diagnóstico por imagem , Doenças Vasculares/diagnóstico por imagem , Adulto , Ponte Cardiopulmonar , Fluordesoxiglucose F18 , Granuloma Piogênico/patologia , Granuloma Piogênico/cirurgia , Humanos , Masculino , Pericárdio/cirurgia , Tomografia por Emissão de Pósitrons , Artéria Pulmonar/patologia , Artéria Pulmonar/cirurgia , Diálise Renal , Esternotomia , Toracotomia , Tomografia Computadorizada por Raios X , Doenças Vasculares/patologia , Doenças Vasculares/cirurgia
20.
Gen Thorac Cardiovasc Surg ; 67(3): 332-335, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29804176

RESUMO

A 27-year-old female patient had presented progressing exertional dyspnea due to pulmonary hypertension. Chest CT revealed diffusely spread patchy ground-glass opacities sparing subpleural parenchymal areas suggesting the diagnosis of pulmonary veno-occlusive disease (PVOD). Despite the diagnosis of PVOD, she was somehow managed by a repetitive escalation of the epoprostenol dose and oxygen supply during the 12-month waiting period until successful bilateral lung transplantation was performed. Pathology demonstrated capillary proliferation in alveolar septae with scarce lesions of narrowed and/or occluded postcapillary small veins, leading to the final diagnosis of pulmonary capillary hemangiomatosis (PCH), not PVOD. We herein present a case of PCH diagnosed after lung transplantation with a focus on its etiology and a key to clinical diagnosis.


Assuntos
Granuloma Piogênico/diagnóstico , Pneumopatias/diagnóstico , Adulto , Diagnóstico Diferencial , Dispneia/etiologia , Feminino , Granuloma Piogênico/complicações , Granuloma Piogênico/patologia , Granuloma Piogênico/cirurgia , Humanos , Hipertensão Pulmonar/etiologia , Pneumopatias/complicações , Pneumopatias/patologia , Pneumopatias/cirurgia , Transplante de Pulmão , Tomografia Computadorizada por Raios X
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