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1.
Middle East Afr J Ophthalmol ; 27(2): 128-130, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32874047

RESUMO

We report two cases with foveal congenital simple hamartoma of the retinal pigment epithelium (CSHRPE), as both patients presented to our retina services complaining of a unilateral decreased vision. Full ophthalmic examination and multimodal imaging were performed including fundus photography, fundus autofluorescence, optical coherence tomography, fluorescein angiography, and electrophysiological testing. Both patients presented with 20/80 vision in the affected eyes. Foveal CSHRPE was found in both eyes, along with parapapillary hyperpigmented rim, multiple pinpoint macular lesions, and few posterior pole hyperpigmented lesions. Multifocal electroretinogram showed diminished central amplitude in both eyes, with three-dimensional topography map showing blunted foveal peaks in one eye and the absence of a central peak in the other patient. Both patients had a stable vision and clinical examination of the CSHRPE during 5 and 6 years follow up, respectively. Foveal CSHRPE is usually symptomatic and results in a decline in visual acuity. Follow-up of these patients showed stable vision and clinical examination.


Assuntos
Hamartoma/congênito , Doenças Retinianas/congênito , Epitélio Pigmentado da Retina/anormalidades , Adulto , Técnicas de Diagnóstico Oftalmológico , Eletrorretinografia , Angiofluoresceinografia , Fóvea Central/patologia , Fundo de Olho , Hamartoma/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Imagem Multimodal , Doenças Retinianas/diagnóstico , Epitélio Pigmentado da Retina/patologia , Tomografia de Coerência Óptica/métodos , Acuidade Visual/fisiologia
2.
Vestn Oftalmol ; 136(4. Vyp. 2): 367-372, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32880163

RESUMO

The article provides a detailed review of the ophthalmoscopic picture, optical coherence tomography (OCT) of the retina and fundus autofluorescence in patients with such rare pathological processes in the fundus as torpedo maculopathy, retinal myelin fibers, retinal astrocytic hamartoma and cavernous hematoma.


Assuntos
Hamartoma , Doenças Retinianas , Angiofluoresceinografia , Humanos , Retina , Tomografia de Coerência Óptica
3.
Zhonghua Bing Li Xue Za Zhi ; 49(8): 847-849, 2020 Aug 08.
Artigo em Chinês | MEDLINE | ID: mdl-32746557

Assuntos
Hamartoma , Pâncreas , Humanos
4.
Oral Maxillofac Surg ; 24(3): 363-368, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32533408

RESUMO

Eruption sequestrum (ES) is a single or even multiple, small whitish calcified masses found within the soft tissue of the opercula overlying the crown of erupting permanent molars of children. We herein report a well-documented case of ES, offering a review of published cases in the English literature. An otherwise healthy 6-year-old girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a faint round radiopacity above and separated from the occlusal surface of the related tooth. The patient was submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopic examination revealed odontogenic epithelium in association with chronic inflammatory infiltrate and small blood vessels in the connective tissue. Small concentric basophilic calcifications, round osteodentin, and pulp-like structures were also observed. The microscopic evaluation of additional cases of ES may improve the understanding of this uncommon inflamed odontogenic hamartoma.


Assuntos
Hamartoma , Dente Molar , Criança , Tecido Conjuntivo , Feminino , Gengiva , Humanos , Coroa do Dente
5.
Medicine (Baltimore) ; 99(20): e20167, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32443333

RESUMO

The purpose of this study is to analyze the risk factors of sporadic renal hamartoma and establish a risk scoring system, and to intervene in patients with high-risk sporadic renal hamartoma who are prone to rupture and bleeding as soon as possible.Retrospective univariate and multivariate logistic analyzes were conducted for clinical data of 332 sporadic renal hamartoma patients to screen out independent risk factors of tumor rupture. Score of each independent risk factor was calculated. (Calculation formula: the risk coefficient of each factor = the beta regression coefficient of each factor/the minimum value of the beta regression coefficient of all factors, the value of the smallest beta regression coefficient corresponding to all the factors was assigned 1 point. The score of each factor was equal to the risk coefficient of each variable was taken as an integer value by rounding.) The total score was equal to the sum of all factors. Then the area under the receiver operating characteristics (AUC) curve was compared between high risk factors and scoring system. Finally, the scoring system was evaluated by the area under the curve (AUC) and the Hosmer-Lemeshow method in an independent cohort of 130 patients.Factors such as symptoms at presentation, tumor size, tumor blood supply, and tumor growth pattern were significant predictors of sporadic renal angiomyolipoma rupture in both the univariate and multivariate analyses; these predictors were included in the scoring system to predict sporadic renal angiomyolipoma rupture. There were no significant differences in AUCs between high risk factors and scoring system (z = 0.6434, P = .583, AUC = 0.913, and 0.903 for high risk factors and scoring system, respectively). The sporadic renal angiomyolipoma patients who scored >6 points were prone to rupture. AUROC of the scoring system in the validation set was 0.854(95%CI:0.779, 0.928). Using the Hosmer-Lemeshow method, the value of X was 2.916, P = .893, suggesting the scoring system fitted well.A scoring system based on clinical features is simple and effective in predicting sporadic angiolipoma rupture and hemorrhage. When the score is higher than 6 points, the probability of hamartoma rupture and hemorrhage is significantly increased and early intervention is needed.


Assuntos
Angiomiolipoma/complicações , Hamartoma/complicações , Hemorragia/diagnóstico , Neoplasias Renais/patologia , Ruptura/diagnóstico , Adulto , China/epidemiologia , Regras de Decisão Clínica , Feminino , Hemorragia/etiologia , Humanos , Neoplasias Renais/irrigação sanguínea , Masculino , Pessoa de Meia-Idade , Projetos de Pesquisa/estatística & dados numéricos , Estudos Retrospectivos , Medição de Risco/métodos , Fatores de Risco , Ruptura/etiologia , Carga Tumoral/fisiologia
6.
Zhonghua Bing Li Xue Za Zhi ; 49(5): 490-492, 2020 May 08.
Artigo em Chinês | MEDLINE | ID: mdl-32392938
7.
Kyobu Geka ; 73(5): 396-399, 2020 May.
Artigo em Japonês | MEDLINE | ID: mdl-32398401

RESUMO

The case was 56 years old male. An abnormal shadow was pointed out by chest computed tomography (CT) at a medical examination. The CT scan revealed a 13 mm mass shadow that contacts with the B5a of the right middle lobe. Bronchoscopy revealed a yellow colored lesion that occluded B5ai. A non-cartilage type endobronchial hamartoma was suspected and the biopsy was performed, but a definitive diagnosis was not achieved. The lesion was surgically resected by the right middle lobectomy, and the histopathological diagnosis was an endobronchial hamartoma consisting mainly of mature adipose tissue.


Assuntos
Hamartoma , Neoplasias Pulmonares , Brônquios , Broncoscopia , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
9.
Medicine (Baltimore) ; 99(11): e19489, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32176087

RESUMO

RATIONALE: Fibrous hamartoma of infancy (FHI) is a rare benign soft-tissue tumor in children with a triphasic organoid histologic appearance. PATIENT CONCERNS: We here report a case with the largest FHI published so far. A 13-month-old boy with a rapidly growing tumor 45 cm in length and 69.3 cm in circumference of the left lower extremity was identified immediately at birth. DIAGNOSES: The diagnosis was uncertain before the operation, although biopsy was conducted. The postoperation histological examination showed arranged spindle cells, adipose tissue, and nests of immature small cells embedded in a myxoid background, which is the characteristic triphasic histology of FHI. INTERVENTIONS: Under general anesthesia, hip and lower extremity amputation was performed. OUTCOMES: The patient was followed-up for 6 years and no signs of recurrence were found, suggesting a favorable prognosis, although a part of the residual tumor was present after the surgery. LESSONS: FHI exhibits pathological and clinical characteristics. However, differential diagnosis of FHI from other soft-tissue tumors before operation remains a challenge. Thus, sometimes, aggressive therapy for the treatment of FHI might be a good choice to get a satisfactory.


Assuntos
Hamartoma/diagnóstico por imagem , Perna (Membro) , Neoplasias de Tecidos Moles/diagnóstico por imagem , Tecido Adiposo/patologia , Amputação , Angiografia por Tomografia Computadorizada , Diagnóstico Diferencial , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia
11.
Zhonghua Yan Ke Za Zhi ; 56(3): 211-216, 2020 Mar 11.
Artigo em Chinês | MEDLINE | ID: mdl-32187950

RESUMO

Objective: To investigate the autofluorescence findings of retinal astrocytic hamartoma (RAH) in patients with tuberous sclerosis complex (TSC). Methods: It was a retrospective case series study. Twenty-three patients (35 eyes) who were referred to Department of Internal Medicine and Department of Ophthalmology, Peking Union Medical College Hospital between November 2012 and June 2018 with established TSC-associated RAH diagnosis were included. The findings of fundus autofluorescence, fundus photos and spectral-domain optical coherence tomography (SD-OCT) were retrospectively reviewed. RAH lesions were classified into three types based on the morphology shown in fundus photos. The fundus autofluorescence features of TSC-associated RAH were described. The Welch's test and Fisher's exact test were used for statistical analysis. Results: The patients were 8 males and 15 females aged (28±9) years old (range, 15-55 years). Seventy-two RAH lesions were examined, including 59 type 1 RAHs, 7 type 2 RAHs and 6 type 3 RAHs. According to fundus autofluorescence, type 1 RAHs could be further divided into reduced, speckled and background autofluorescence patterns, among which the hypoautofluorescence pattern accounted for the majority (69.5%, 41/59), while the speckled pattern was usually accompanied by outer retinal disorganization and discontinuation of photoreceptor outer segment as revealed by SD-OCT. No significant difference was revealed in tumor thickness for reduced, speckled and background autofluorescence patterns of type 1 RAHs [(490.2±97.9) vs. (589.2±221.6) vs. (463.0±76.2) µm respectively, F=1.426, P=0.283]. Among type 1 RAHs, the number of reduced autofluorescence pattern lesions found in perifoveal, peripapillary, inferonasal, inferotemporal, superonasal, superotemporal quadrants were 9, 4, 4, 7, 4, 13 respectively, while that of speckled autofluorescence pattern lesions were 3, 0, 3, 2, 3, 2 and background autoflurorescence pattern lesions 3, 0, 1, 1, 0, 0. No significant difference was revealed in location distribution (P=0.452) either. Type 2 RAHs featured numerous hyperautofluorescent spots or plaques, and calcification in type 2 RAHs varied in autofluorescence intensity. Type 3 RAHs, combining the features of type 1 and 2 RAHs, were characterized by central hyperautofluorescent spots and hypoautoflurescent rim, but the area of hyperautofluorescence was smaller than that of calcification as shown in fundus photos. Conclusions: In TSC, the fundus autofluorescence of RAHs varies from hypoautofluorescence to hyperautofluorescence patterns according to RAH types. The retinal involvement and calcification degree of TSC-associated RAHs could be reflected on the autofluorescence, which was beneficial to the full assessment. (Chin J Ophthalmol, 2020, 56: 211-216).


Assuntos
Fundo de Olho , Hamartoma/diagnóstico por imagem , Retina/patologia , Doenças Retinianas/diagnóstico por imagem , Esclerose Tuberosa/complicações , Adolescente , Adulto , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Retina/diagnóstico por imagem , Estudos Retrospectivos , Tomografia de Coerência Óptica , Adulto Jovem
13.
Clin Imaging ; 62: 49-56, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32066033

RESUMO

PURPOSE: The purpose of this study was to determine whether the computed tomography (CT) features might be used in distinguishing pulmonary carcinoids from hamartomas. MATERIALS AND METHODS: Ninety solid pulmonary nodules (43 carcinoids and 47 hamartomas) in 90 patients were evaluated. The following CT scan features were evaluated: size, location (peripheral/central), contour (lobulated/nodular), number of lobulation, attenuation, calcification, endobronchial status, bronchial extension and involvement, parenchymal abnormalities distal to the lesion e.g. hyperlucency, atelectasis, and nodularity. The final pathologic diagnosis of the lesions and bronchial extension were confirmed by review of histopathological specimens. RESULTS: Out of 43 carcinoids, 37 (86%) were typical. Twenty-three carcinoids and four hamartomas were central (p < 0.001). Ten carcinoids and one hamartoma were endobronchial. The majority of tumors had lobulated contours (65% of carcinoids, 44% of hamartomas) and carcinoids tended to have more lobulations (p = 0.052). Distal nodularity (p = 0.001), distal hyperlucency (p < 0.001), and atelectasis (p = 0.005) were significantly more common in carcinoids. Carcinoids had significantly more bronchial extension and involvement (p < 0.001; respectively). In addition, a new sign that we call "bronchial triangle sign" differentiated carcinoids with a sensitivity and specificity of 84.9% (95% CI: 69,1%-93.4%) and 91% (95% CI: 79.7%-96.6%). CONCLUSION: To the best of our knowledge this is the first study on discrimination of carcinoids and hamartomas. A new CT sign called "bronchial triangle sign" might be used to differentiate carcinoids from hamartomas. Distal parenchymal abnormalities are more common in carcinoids than in hamartomas.


Assuntos
Neoplasias Brônquicas/diagnóstico por imagem , Tumor Carcinoide/diagnóstico por imagem , Hamartoma/diagnóstico por imagem , Adulto , Idoso , Brônquios/diagnóstico por imagem , Brônquios/patologia , Neoplasias Brônquicas/diagnóstico , Carcinoma Neuroendócrino , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atelectasia Pulmonar , Tomografia Computadorizada por Raios X/métodos
14.
Retina ; 40(4): e15-e16, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32032257
16.
J Craniofac Surg ; 31(2): e184-e185, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32028359

RESUMO

Congenital bifid tongue is a rare malformation, which is usually present in association with other oral findings such as cleft palate and tongue mass. The authors present a rare case of congenital bifid tongue together with cleft palate, labial-buccal frenulum deformity, absence of lingual frenulum, and 3 hamartomas in the oral cavity. The authors excised oral hamartomas and repaired the palate and tongue with satisfactory results.


Assuntos
Fissura Palatina/cirurgia , Hamartoma/cirurgia , Doenças da Boca/cirurgia , Língua/cirurgia , Fissura Palatina/complicações , Feminino , Hamartoma/complicações , Humanos , Lactente , Freio Lingual , Doenças da Boca/complicações
19.
Trop Doct ; 50(1): 68-70, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31451057

RESUMO

Brunner's gland hamartoma (or Brunneroma) is an uncommon tumour with an incidence of <0.01%, accounting for approximately 5-10% of benign duodenal tumours. Usually asymptomatic, it may manifest occasionally with duodenal obstruction or upper gastrointestinal haemorrhage and rarely with biliary fistulation, cholestatic jaundice and intussusception. It may be associated with uraemia and chronic pancreatitis. The diagnosis is usually confirmed by imaging studies and upper gastrointestinal endoscopy. Surgical excision or endoscopic resection is preferred for symptomatic large hamartomas. Here we report a case of 45-year-old man presenting with features of pancreatitis and gastric outlet obstruction due to a large Brunner's gland hamartoma, on his endoscopic, radiologic, surgical and pathologic findings.


Assuntos
Glândulas Duodenais/patologia , Neoplasias Duodenais/complicações , Obstrução da Saída Gástrica/etiologia , Hamartoma/complicações , Pancreatite/etiologia , Glândulas Duodenais/diagnóstico por imagem , Glândulas Duodenais/cirurgia , Neoplasias Duodenais/diagnóstico por imagem , Neoplasias Duodenais/patologia , Neoplasias Duodenais/cirurgia , Obstrução da Saída Gástrica/diagnóstico por imagem , Obstrução da Saída Gástrica/patologia , Obstrução da Saída Gástrica/cirurgia , Hamartoma/diagnóstico por imagem , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Pancreaticoduodenectomia , Pancreatite/diagnóstico por imagem , Pancreatite/patologia , Pancreatite/cirurgia , Resultado do Tratamento
20.
J Craniofac Surg ; 31(1): e65-e67, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31609950

RESUMO

Seromucinous hamartoma (SH) is a rarely seen benign polypoid mass of the sinonasal tract. Although the most common presentation symptom is nasal obstruction, most of the patients are asymptomatic. In this paper, the authors present an additional case of SH and discuss its differential diagnosis. A 34-year-old male patient presented with progressive nasal obstruction and serous nasal discharge for several months. A well-defined polypoid mass was detected in the left nasal cavity during the endoscopic assessment. Preoperative biopsy was reported as benign polypoid lesion. The mass was resected via transnasal endoscopic approach and final pathological examination was notified as SH.The SH is an uncommon tumor, originates from nasal septum in the most cases and presents as a well-circumscribed polypoid mass. Radiological imaging modalities and biopsy should be performed to distinguish from the sinonasal malignancies. Complete surgical excision is recommended treatment and recurrence is almost never.


Assuntos
Hamartoma/cirurgia , Cavidade Nasal/cirurgia , Adulto , Biópsia , Hamartoma/complicações , Hamartoma/diagnóstico por imagem , Humanos , Masculino , Cavidade Nasal/diagnóstico por imagem , Obstrução Nasal/etiologia , Septo Nasal/diagnóstico por imagem , Septo Nasal/cirurgia
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