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1.
Medicine (Baltimore) ; 99(11): e19489, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32176087

RESUMO

RATIONALE: Fibrous hamartoma of infancy (FHI) is a rare benign soft-tissue tumor in children with a triphasic organoid histologic appearance. PATIENT CONCERNS: We here report a case with the largest FHI published so far. A 13-month-old boy with a rapidly growing tumor 45 cm in length and 69.3 cm in circumference of the left lower extremity was identified immediately at birth. DIAGNOSES: The diagnosis was uncertain before the operation, although biopsy was conducted. The postoperation histological examination showed arranged spindle cells, adipose tissue, and nests of immature small cells embedded in a myxoid background, which is the characteristic triphasic histology of FHI. INTERVENTIONS: Under general anesthesia, hip and lower extremity amputation was performed. OUTCOMES: The patient was followed-up for 6 years and no signs of recurrence were found, suggesting a favorable prognosis, although a part of the residual tumor was present after the surgery. LESSONS: FHI exhibits pathological and clinical characteristics. However, differential diagnosis of FHI from other soft-tissue tumors before operation remains a challenge. Thus, sometimes, aggressive therapy for the treatment of FHI might be a good choice to get a satisfactory.


Assuntos
Hamartoma/diagnóstico por imagem , Perna (Membro) , Neoplasias de Tecidos Moles/diagnóstico por imagem , Tecido Adiposo/patologia , Amputação , Angiografia por Tomografia Computadorizada , Diagnóstico Diferencial , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia
2.
Autops. Case Rep ; 9(4): e2019107, Oct.-Dec. 2019.
Artigo em Inglês | LILACS | ID: biblio-1023992
3.
Medicine (Baltimore) ; 98(50): e18372, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31852146

RESUMO

RATIONALE: Mammary hamartoma is a rare benign breast tumor, composed of ducts, lobules, fibers, and adipose tissue. We describe a mammary hamartoma in a man; this is the fourth case being reported in the literature. PATIENT CONCERNS: A 30-year-old man presented with a 1-month history of a painless mass in his right breast. DIAGNOSIS: Ultrasound imaging and mammography revealed a lesion, approximately 2.0 cm × 2.0 cm in size, in the right breast, which was considered to be either a lipomyoma or an adenoma fibrosum. INTERVENTIONS: The mass was surgically resected. Pathological examination confirmed the diagnosis of mammary hamartoma. OUTCOMES: The patient was discharged from the hospital after surgery. There was no sign of reoccurrence during a 1-year follow-up period. LESSONS: At present, mammary hamartoma is considered to be a benign lesion, usually treated by surgical resection. Some reports have suggested a possible association between a hamartoma and the development of breast malignancy. The pathology and biology of an association between a mammary hamartoma and malignancy have not been defined to date.


Assuntos
Neoplasias da Mama Masculina/patologia , Hamartoma/patologia , Adulto , Neoplasias da Mama Masculina/diagnóstico , Neoplasias da Mama Masculina/cirurgia , Hamartoma/diagnóstico , Hamartoma/cirurgia , Humanos , Masculino , Mamografia , Ultrassonografia
5.
Ophthalmic Plast Reconstr Surg ; 35(6): e145-e147, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31574042

RESUMO

Trichodiscomas are benign tumors of the skin which develop around a hair follicle. They usually present on the face, neck, or trunk region. The authors report a rare case of a 63-year-old man who presented with a tumor on the left lower eyelid that was histologically proven to be a trichodiscoma of conjunctival origin.Trichodiscomas are benign tumors of the skin appendage which develop around a hair follicle. Although conjunctival hair follicles are rudimentary and do not give rise to hair, rarely a benign proliferation of these cells can result in trichodiscoma of the conjunctiva.


Assuntos
Túnica Conjuntiva/patologia , Neoplasias Palpebrais/patologia , Hamartoma/patologia , Neoplasias Cutâneas/patologia , Humanos , Masculino , Pessoa de Meia-Idade
6.
Ned Tijdschr Geneeskd ; 1632019 10 02.
Artigo em Holandês | MEDLINE | ID: mdl-31580030

RESUMO

A 52-year-old woman was referred to a dermatologist with a changed yellowish lesion on her scalp. Histological features were those of a sebaceous naevus with secondary malignant differentiation into superficial and solid basal cell carcinoma. A sebaceous naevus is a benign, congenital, hamartomatous lesion. In adulthood, secondary neoplasms may develop within them.


Assuntos
Carcinoma Basocelular/patologia , Neoplasias de Cabeça e Pescoço/patologia , Nevo/patologia , Neoplasias das Glândulas Sebáceas/patologia , Neoplasias Cutâneas/patologia , Feminino , Hamartoma/patologia , Humanos , Pessoa de Meia-Idade , Couro Cabeludo/patologia
7.
Arch. Soc. Esp. Oftalmol ; 94(9): 449-452, sept. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-186225

RESUMO

Introducción: El hamartoma astrocítico retiniano es un tumor benigno generalmente asintomático, asociado o no al complejo de esclerosis tuberosa. La hemorragia vítrea es una rara presentación. Caso clínico: Paciente de 12 años acude por visión de "una mancha negra" en el hemicampo temporal superior del ojo derecho. Refiere un episodio similar hace 2 años. En lámpara de hendidura el polo anterior es normal. En la funduscopia se evidencia una masa de aspecto translúcido blanco-amarillenta peripapilar y hemorragia vítrea peripapilar. Las características de la autofluorescencia, angiografía fluoresceínica y la tomografía de coherencia óptica son compatibles con un hamartoma astrocítico retiniano. Los estudios complementarios (serología y radiografías) y examen clínico completo descartan afectación sistémica asociada. Se procedió a un seguimiento estrecho del paciente hasta reabsorción de la hemorragía vítrea. Conclusión: La hemorragia vítrea es una rara complicación de hamartoma astrocítico retiniano y dificulta la exploración fundoscópica. Debería descartarse afectación sistémica


Introduction: Retinal astrocytic hamartoma is generally an asymptomatic benign tumour that may or may not be associated with the tuberous sclerosis complex. Haemorrhage is a rare presentation. Case report: The case concerns a 12-year-old patient with "a black spot" vision in the upper temporal hemifield of the right eye, who referred a similar episode 2 years ago. The anterior pole was normal in the slit lamp. A mass of translucent white-yellow peri-papillary appearance and vitreous peri-papillary haemorrhage was observed in funduscopy. The autofluorescence, fluorescence angiography, and optical coherence tomography characteristics were all compatible with retinal astrocytic hamartoma. Complementary studies (serology and X-rays) and the complete clinical examination rule out associated systemic involvement. The patient was followed-up closely until the vitreous haemorrhage was reabsorbed. Conclusion: Vitreous haemorrhage is a rare complication of Retinal astrocytic hamartoma and funduscopic exploration is difficult. Systemic involvement should be ruled out


Assuntos
Humanos , Criança , Hamartoma/diagnóstico , Doenças Retinianas/diagnóstico , Hemorragia Vítrea/etiologia , Astrócitos/patologia , Angiofluoresceinografia , Hamartoma/patologia , Doenças Retinianas/patologia , Microscopia com Lâmpada de Fenda , Tomografia de Coerência Óptica
8.
BMJ Case Rep ; 12(8)2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31391168

RESUMO

Benign tumours of the tonsils are rare. Majority of these lesions are diagnosed as squamous papilloma. Hamartoma is a benign tumor-like malformation. Hamartoma in tonsils is unique and only a few anecdotal cases are reported until now. Tonsillar hamartoma usually presents as unilateral or bilateral polyp with clinical features of dysphagia or foreign body sensation. Histopathologically, normal tissues are noted in a haphazard or disorganised way. We hereby present a case of 31-year-old male patient with tonsillar hamartomatous polyp presenting with the symptom of a foreign body sensation in the throat. The diagnosis of this entity and its distinction from other clinico-pathological mimickers require histopathological examination and awareness. A complete surgical excision is curative without any evidence of disease recurrence.


Assuntos
Hamartoma/patologia , Pólipos/patologia , Neoplasias Tonsilares/patologia , Adulto , Hamartoma/cirurgia , Humanos , Masculino , Pólipos/cirurgia , Neoplasias Tonsilares/cirurgia
9.
BMJ Case Rep ; 12(8)2019 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-31383684

RESUMO

Respiratory epithelial adenomatoid hamartoma (REAH) is a rare lesion in nasal cavity first reported by Wenig and Heffner in 1995. Most commonly seen in men in third to ninth decade of life. Majority of cases presents as a polypoidal mass in one or both nasal cavities. We experienced such a case of REAH originating from the nasal septum, in posterior aspect, treated by endoscopic approach. It is important to differentiate REAH from other sinonasal pathologies like inverted papilloma and low grade sinonasal adenocarcinoma. Complete surgical resection is the treatment of choice.


Assuntos
Adenoma/diagnóstico , Hamartoma/diagnóstico , Pólipos Nasais/diagnóstico , Neoplasias Epiteliais e Glandulares/diagnóstico , Neoplasias Nasais/diagnóstico , Adenoma/patologia , Diagnóstico Diferencial , Hamartoma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Cavidade Nasal/patologia , Pólipos Nasais/complicações , Neoplasias Epiteliais e Glandulares/etiologia , Neoplasias Nasais/etiologia
10.
BMC Musculoskelet Disord ; 20(1): 356, 2019 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-31376836

RESUMO

BACKGROUND: Fibrous hamartoma of infancy(FHI) is a rare benign lesion most frequently occurring within the first year of life. So far, just over 200 cases have been reported in the English literature, in which the radiologic findings of FHI have not been fully described. Herein, 2 adult cases of FHI receiving treatment in our hospital and the published cases searched on PubMed are reviewed, with the emphasis on the discussion of the spectrum of MR findings and their histologic correlation. CASE PRESENTATION: We present two adult cases who aged 47 years and 19 years with slow growing masses beginning from their childhood in the posterior craniocervical area. On CT and MR imaging, the tumours showed as the superficially located lesions with ill-defined margins that involved the subcutaneous layer and its underlying muscles. The size of the lesions were 21.3 × 16.7 × 16 cm in case 1 and 20.2 × 19.3 × 13.6 cm in case 2. The tumours demonstrated heterogeneous intensities/signals with the adipose tissue presenting as the disperse strands or small focus of fatty intensity/signal. Parallel or whirling appearance, and dilated vessels were delineated in the cases. Contrast enhancement was administered in case 1 and marked enhancement was found. CONCLUSIONS: The usually observed manifestation of FHI on CT and/or MR imaging is the strands of adipose/fibrous intensities traversing the lesions, with the characteristic parallel or whirling appearance in some cases. The tumours with ill-defined margins have the tendency to involve the underlying muscles. Some fibroblastic and adipocytic tumours should be ruled out in differential diagnosis.


Assuntos
Hamartoma/diagnóstico por imagem , Tela Subcutânea/patologia , Diagnóstico Diferencial , Feminino , Fibrose , Hamartoma/patologia , Hamartoma/cirurgia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Pescoço , Tela Subcutânea/diagnóstico por imagem , Tela Subcutânea/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
11.
Medicine (Baltimore) ; 98(31): e16640, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31374034

RESUMO

RATIONALE: Tumors in the heart are rare. Myxomas, rhabdomyomas, and fibromas are the most common benign cardiac tumors. Hamartoma of mature cardiomyocytes (HMCM) is another benign cardiac tumor, are very rare and have only been reported in a few literatures. PATIENT CONCERNS: We report a case of 41-year-old male who suffered short of breath for 3 years, and lower limbs edema for 2 years. DIAGNOSES: Transthoracic echocardiogram (TTE) and cardiac magnetic resonance (CMR) showed a large amount of pericardial effusion and confirmed a mass of 18 × 14 mm on the superior vena cava near the outer edge of right atrium. The patient was first diagnosed as pleural mesothelioma. Surgery was performed to relieve the symptoms and confirm diagnoses. However, during surgery, we found the right atrium is apparently thicken with rough and uneven surface. Histology of right atrium mass indicated it as hamartoma of mature cardiomyocytes. INTERVENTION: We resected the thicken atrial wall completely, reconstructed right atrium with bovine pericardial patch, and resected the pericardium. OUTCOMES: Patient was discharged 9 days after surgery, and remained asymptomatic during 9 months follow up. LESSONS: Hamartoma of mature cardomyocytes is a rare benign cardiac tumor. There were 26 cases reported until now. The conclusive diagnosis depends on pathological sections. For patients with symptoms, surgery is an effective treatment for HMCM.


Assuntos
Hamartoma/patologia , Átrios do Coração/patologia , Cardiopatias/patologia , Miócitos Cardíacos/patologia , Adulto , Dispneia/etiologia , Ecocardiografia , Edema/etiologia , Hamartoma/complicações , Hamartoma/cirurgia , Cardiopatias/complicações , Cardiopatias/cirurgia , Humanos , Masculino
12.
BMC Gastroenterol ; 19(1): 151, 2019 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-31443637

RESUMO

BACKGROUND: With the development and application of endoscopic technology, most pedunculated polyps can be absolutely resected with a complete specimen by hot snare polypectomy (HSP). Brunner's gland hamartoma (BGH) is a rare benign small bowel tumor. The majority of BGH measuring about 2 cm in diameter, rarely larger than 5 cm. Most patients are asymptomatic, some may present with gastrointestinal hemorrhage or intestinal obstruction. Symptomatic larger lesions leading to bleeding or obstruction should be excised either endoscopically or surgically. Whether it is safe and effective that removing a BGH measuring about 7 cm by HSP is not known. CASE PRESENTATION: Here, we reported a rare case of a proximal duodenum pedunculated mass measuring about 7 cm which was responsible for the patient's severe anemia. we treated it as a pedunculated polyp. After being pretreated the stalk with an endoloop which was placed around the base of the mass to prevent post-polypectomy bleeding (PPB), the pedunculated BGH was removed by HSP completely. The stalk of the mass was negative. We achieved a curative resection. CONCLUSION: It is a safe and effective for our patient to treat the pedunculated BGH measuring about 7 cm as a pedunculated polyp and remove it by HSP. And future prospective studies in larger cohorts are needed to confirm it.


Assuntos
Glândulas Duodenais/patologia , Duodenopatias , Endoscopia/métodos , Hamartoma , Pólipos Intestinais , Dissecação/métodos , Duodenopatias/patologia , Duodenopatias/fisiopatologia , Duodenopatias/cirurgia , Feminino , Hamartoma/patologia , Hamartoma/fisiopatologia , Hamartoma/cirurgia , Humanos , Pólipos Intestinais/patologia , Pólipos Intestinais/fisiopatologia , Pólipos Intestinais/cirurgia , Pessoa de Meia-Idade , Resultado do Tratamento , Carga Tumoral
17.
Clin Nucl Med ; 44(11): 892-894, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31274563

RESUMO

Hamartoma of mature cardiac myocytes is an extremely rare type of benign cardiac tumor with a slow growth rate and generally occurs in adults. We report a case with hamartoma of mature cardiac myocytes of the right auricle demonstrating intense F-FDG uptake and a large amount of pericardial effusion on PET/CT mimicking malignancy in a 41-year-old man. Hamartoma of mature cardiac myocytes should be considered among the differential diagnoses when an F-FDG-avid primary focal cardiac mass is found in patients with malignant features on PET/CT imaging.


Assuntos
Fluordesoxiglucose F18 , Hamartoma/diagnóstico por imagem , Hamartoma/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Miócitos Cardíacos/patologia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Adulto , Diagnóstico Diferencial , Humanos , Masculino
18.
Acta Gastroenterol Belg ; 82(2): 257-260, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31314185

RESUMO

It has recently been shown that duodenal foveolar gastric metaplasia (FGM) sometimes presents as a polyp. The mechanism by which FGM develops into a polypoid lesion is unknown and it is unclear whether this form of FGM is indistinguishable from other polypoid lesions or whether endoscopists do not recognize it because they are unfamiliar with it. We identified and retrieved archival cases of FGM endoscopically suspicious for adenomatous polyp and examined their pathological, clinical and endoscopic features. Endoscopic features of the 13 identified FGMs presenting as polyps were heterogeneous and overlapping with those of adenomatous polyps. FGM was frequently associated with mucosal and submucosal Brunner's glands, but defining and recognizing hyperplasia of these glands remains difficult. Other pathological features could not explain the development of a polypoid lesion. The endoscopic features of FGM polyps are non-specific, overlapping with those of adenomatous polyps. FGM polyps probably acquire their polypoid aspect due to association with Brunner's gland hyperplasia (BGH), which also arises due to chronic inflammation and damage. Because BGH is ill-defined and difficult to recognize, while FGM is diagnosed easily, this type of polypoid lesions has until now only been recognized based on the presence of FGM, although FGM is most likely a secondary phenomenon and not the primary cause of the polyp.


Assuntos
Glândulas Duodenais/diagnóstico por imagem , Úlcera Duodenal/patologia , Endoscopia do Sistema Digestório , Hamartoma/patologia , Pólipos Intestinais , Metaplasia , Glândulas Duodenais/patologia , Duodenopatias/diagnóstico por imagem , Duodenopatias/patologia , Hamartoma/diagnóstico por imagem , Humanos , Pólipos Intestinais/diagnóstico por imagem , Pólipos Intestinais/patologia , Metaplasia/diagnóstico por imagem , Metaplasia/patologia
20.
Pediatr Dermatol ; 36(5): 728-729, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31250468

RESUMO

Fibrolipomatous hamartomas are asymptomatic, subcutaneous lumps usually located on the infant's heels. There is wide heterogeneity in the naming of and management of this condition. Ultrasound examination permits a clear distinction from other disorders. We report herein a case of palmoplantar fibrolipomatous hamartomas.


Assuntos
Hamartoma/patologia , Mãos , Calcanhar , Lipoma/patologia , Dermatopatias/patologia , Humanos , Lactente , Masculino
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