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1.
Medicine (Baltimore) ; 99(35): e21985, 2020 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-32871948

RESUMO

Non-invasive biomarkers, such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios, may predict inflammation in various disorders, including gastritis, according to recent data. Nevertheless, various studies reported an association between Helicobacter pylori (H pylori) and immune thrombocytopenia in both adults and pediatric patients. The objective of our study was to evaluate the impact of pediatric gastritis, caused or not by H pylori infection on erythrocytes, their parameters, thrombocytes, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).We performed a prospective, case-control study on 151 patients aged between 1 and 17 years who presented with chronic dyspeptic symptoms. An upper digestive endoscopy with gastric biopsies and a complete blood count was performed in each case.Control group consisted of 67 patients with normal histological findings, while the two study groups were divided into group 1-H pylori-induced gastritis (31 patients) and group 2-non-H pylori-induced gastritis (53 patients). Children from the rural area were more likely to develop both types of gastritis (P < .01). No significant difference was found between either of the study groups and control group in terms of platelets, mean platelet volume, NLR and PLR (P > .05). However, significantly higher values of lymphocytes were associated with non-H pylori-induced gastritis (P < .01). Comparison of the two study groups did not reflect any significant differences in terms of hematological parameters. When assessing these constants in relation to gastritis severity, severe gastritis led to a compelling decrease in hemoglobin (Hb) and hematocrit (Htc) levels. The comparison of parameters between severe, moderate, and mild gastritis did not reveal any significant results.Childhood and adolescent gastritis does not produce a significant effect upon platelet counts, their mean volume, PLR or NLR, according to our study. An important increase in lymphocyte count might predict non-H pylori pediatric gastritis. Moreover, severe gastritis might result in an important decrease in Hb and Htc levels.


Assuntos
Gastrite/sangue , Infecções por Helicobacter/sangue , Adolescente , Estudos de Casos e Controles , Criança , Feminino , Gastrite/microbiologia , Helicobacter pylori/isolamento & purificação , Humanos , Contagem de Linfócitos , Masculino , Estudos Prospectivos
2.
Rev Prat ; 70(3): 301-304, 2020 Mar.
Artigo em Francês | MEDLINE | ID: mdl-32877065

RESUMO

Helicobacter pylori infection in children. Clinical manifestations are not specific in the course of H. pylori infection in children and in most cases the infection is asymptomatic. The initial diagnosis is based on upper gastrointestinal endoscopy with biopsy-based methods (culture, PCR, histology and rapid urease test). Treatment should be based on the results of the antibiotic (particularly clarithromycin) susceptibility testing of the isolated strains (antibiogram and/or PCR) with a good therapeutic adherence more than 90%. Finally, according to the last pediatric recommendations the treatment duration is 14 days for the triple therapy (proton pump inhibitor + two antibiotics).


Assuntos
Infecções por Helicobacter , Helicobacter pylori , Antibacterianos/uso terapêutico , Criança , Claritromicina/uso terapêutico , Quimioterapia Combinada , Infecções por Helicobacter/tratamento farmacológico , Humanos , Inibidores da Bomba de Prótons/uso terapêutico
3.
Wiad Lek ; 73(7): 1489-1491, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32759443

RESUMO

OBJECTIVE: The aim: Determine the frequency of surgery-appendectomy of patients with chronic non-atrophic gastritis and the impact of this transaction on the pathogenesis of chronic gastritis. PATIENTS AND METHODS: Materials and methods: Data of disease history and life were analyses, as well as the results of a comprehensive survey of 245 patients with chronic non-atrophic gastritis. Comprehensive examination included: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous. RESULTS: Results: Helicobacter infection was detected in 100% of cases. It was found that 56 (22.9%) of patients were subjected to appendectomy. Age of patients, who had an appendectomy ranged from 4 to 40 years and averaged 18.34 ± 1.05 years, and the first pathological manifestations of the gastro-intestinal tract appeared in an average of 28.27± 1.75 year, i.e. in 10 years. As for the age qualification pupil were the earliest pathological manifestations appeared in a group of patients from 11 to 15 years (13 people (23.2%) and amounted to about 6 years after the operation, and 6 (46.2%) patients, manifestations appeared in 2-6 months after surgery; the most recent is in group from 16 to 20 years (19 people (33.9%) and amounted to about 14 years (p < 0.05). CONCLUSION: Conclusions: Surgery on the body of immune system - appendix provokes activation of latent form of chronic non-atrophic gastritis, especially during puberty.


Assuntos
Gastrite Atrófica , Helicobacter pylori , Adolescente , Adulto , Apendicectomia , Criança , Pré-Escolar , Infecções por Helicobacter , Humanos , Adulto Jovem
4.
Zhonghua Yi Xue Za Zhi ; 100(32): 2511-2517, 2020 Aug 25.
Artigo em Chinês | MEDLINE | ID: mdl-32829598

RESUMO

Objective: To explore the clinical features and prognosis of gastric mucosa-associated lymphoid tissue lymphoma. Methods: The data of patients with gastric mucosa-associated lymphoid tissue lymphoma diagnosed and treated at Peking University Cancer Hospital from 2000 to 2019 were collected, and their clinical characteristics, treatment options and effects, and prognosis were retrospectively analyzed. Results: The median age of 68 patients was 56 years old, and the ratio of men to women was 0.6∶1.0. Early patients accounted for about 76% (52/68). The most commonly used treatment is Helicobacter pylori eradication, followed by radiotherapy and chemotherapy. The total effective rate is 94%, of which the complete remission rate is 72%. With a median follow-up of 44 months, the 5-year progression-free survival (PFS) rate was 73%, and the overall survival (OS) rate was 83%. Prognostic factor analysis showed that albumin level (P=0.011) and international prognostic index (IPI)(P=0.017) are independent prognostic indicators of PFS, The 5-year PFS rate of patients with normal and reduced albumin was 77% and 50%, respectively, and the 5-year PFS rate of patients with IPI score<2 points and IPI ≥ 2 points was 80% and 48%, respectively. Lactate dehydrogenase (LDH) (P=0.016) and albumin level (P=0.025) are independent prognostic indicators of OS, and the 5-year OS rates of patients with normal and elevated LDH were 87% and 67%, respectively. The 5-year OS rates of patients with normal albumin and reduced were 92% and 73%, respectively. Conclusions: Gastric mucosa-associated lymphoid tissue lymphoma is sensitive to treatment and has a good prognosis. The patient's albumin and lactate dehydrogenase levels are independent prognostic indicators.


Assuntos
Helicobacter pylori , Linfoma de Zona Marginal Tipo Células B , Neoplasias Gástricas , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
5.
West Afr J Med ; 37(4): 362-367, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32835397

RESUMO

BACKGROUND AND OBJECTIVE: Gastrointestinal diseases account for significant morbidity and mortality across the world. The study aims at establishing the epidemiological profile of gastrointestinal diseases in a Nigerian tertiary care center. METHODS: This is a descriptive retrospective study of all gastrointestinal specimens, submitted to the histopathology department of Delta State University Teaching Hospital (DELSUTH) for diagnosis. The age, sex, and histological diagnosis were extracted from the archives of the department. These were re-reclassified into diagnostic groups, analyzed using Excel spread sheet 2007 and summarized in tables. RESULTS: The study involves 570 patients (290 males and 280 females) with gastrointestinal tract (GIT) diseases within the age range of 10 days to 99 years, and of a mean age of 48.4 years. Congenital, inflammatory, benign neoplasms, malignant neoplasms and vascular diseases accounted for 1.6%, 77.5%, 2.6%, 18.1% and 0.18% of the cases respectively. These lesions were domiciled in the esophagus (1.4%), stomach (53.3%), small intestine (7.9%), appendix (10%), colorectum (25.4%) and anus (2%). The peak incidence corresponded to the 5th decade with 72.5% of cases affecting patients of 30-69 years. Malignant lesions were found in the esophagus (5.8%), stomach (14.6%), small intestine (4.9%), colorectum (72.8%) and anus (1.9%) and were mostly adenocarcinomas. CONCLUSION: The study showed that GIT lesions were slightly more common among males. Majority of cases were inflammatory diseases (gastritis, appendicitis) with GIT cancers (colorectal and gastric cancer) being the next most common. The preponderance of GIT lesions among the productive age calls for action to ameliorate the trend. Preventive public enlightenment campaign on GIT cancer risk factors and population-based screening programmes especially for Helicobacter pylori infection and colorectal cancer is highly recommended.


Assuntos
Trato Gastrointestinal , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Infecções por Helicobacter , Helicobacter pylori , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Estudos Retrospectivos , Centros de Atenção Terciária , Adulto Jovem
6.
West Afr J Med ; 37(4): 377-384, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32835399

RESUMO

BACKGROUND: Gastric cancer develops from chronic gastritis through distinct precancerous lesions which include atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia in a sequential manner, all of which are related to Helicobacter pylori (H. pylori) infection. We determined the prevalence of H. pylori infection and the gastric premalignant conditions in a Southwestern Nigerian population with chronic gastritis. MATERIALS AND METHODS: A prospective cross-sectional study conducted on 252 adult patients with dyspepsia at a faith-based tertiary health facility in Nigeria. Gastroscopy was performed on all the participants and five gastric biopsies were taken from each of them. Standard histological examination for H. pylori, gastritis and the precancerous lesions was performed on the specimens. The biopsy sampling and histological examination were performed in line with the Updated Sydney System recommendations. We summarized data by Means ± Standard Deviation, frequencies and percentages. Associations between categorical variables were tested by means of Chi-square test or Fisher exact test as appropriate. The cutoff for statistical significance was P-value < 0.05. RESULTS: A total of 78 (31.0%) subjects tested positive by histology for H. pylori infection. Of all the gastric precancerous lesions, AG had the highest prevalence [54 (21.4%)], followed by dysplasia [6 (2.4%)] and IM [3 (1.2%)]. Regarding the severity of the precancerous lesions, 47 (87.0%) subjects had mild AG while 7 (13.0%) had moderate AG. All the subjects with IM and dysplasia had mild or low-grade lesions. CONCLUSION: The prevalence rates of gastric precancerous lesions in our study population were low.


Assuntos
Infecções por Helicobacter , Helicobacter pylori , Lesões Pré-Cancerosas , Estudos Transversais , Humanos , Nigéria , Estudos Prospectivos
11.
Arq Bras Cir Dig ; 33(2): e1506, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32844883

RESUMO

BACKGROUND: Acid inhibition from chronic proton pump inhibitor use and a possible increase in gastrin can lead to changes in the regulation of hydrochloric acid production. However, it has not known whether such chronic use changes the presence of gastrin, delta, and enterochromaffin-like cells in the stomach or the relationship between gastrin and delta cells. AIM: To analyze the number of gastrin-producing gastrin cells, somatostatin-producing cells, and histamine-producing cells in patients who were chronic users of proton pump inhibitor, with or without related Helicobacter pylori infection. METHODS: Biopsies from 105 patients, including 81 chronic proton pump inhibitor users (experimental group) and 24 controls, were processed immunohistochemically and subjected to counting of gastrin, delta, and enterochromaffin-like cells in high-magnification microscopic fields and in 10 glands. RESULTS: Gastrin cell, delta cell, and enterochromaffin-like cells counts were similar across the groups and appeared to be unaffected by Helicobacter pylori infection. The ratio between gastrin cells and delta cells was higher in the chronic users of proton pump inhibitor group than in controls. CONCLUSION: Chronic users of proton pump inhibitor does not affect gastrin cell, delta cell, and enterochromaffin-like cell counts significantly, but may alter the ratio between gastrin cells and delta cells.


Assuntos
Celulas Tipo Enterocromafim/metabolismo , Gastrinas/sangue , Infecções por Helicobacter/terapia , Helicobacter pylori/isolamento & purificação , Inibidores da Bomba de Prótons/uso terapêutico , Bombas de Próton/metabolismo , Gastropatias/induzido quimicamente , Estudos de Casos e Controles , Celulas Tipo Enterocromafim/efeitos dos fármacos , Gastrinas/fisiologia , Infecções por Helicobacter/diagnóstico , Humanos , Inibidores da Bomba de Prótons/efeitos adversos , Estômago , Gastropatias/sangue
12.
Medicine (Baltimore) ; 99(32): e20761, 2020 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-32769862

RESUMO

The regimens containing levofloxacin (LVX) have been recommended as an alternate to standard triple therapy to treat Helicobacter pylori infections and H pylori mixed infection always lead to H pylori chronic infection. Although the molecular mechanism of LVX resistance with gyrA gene mutation has been clearly understood in H pylori, other genes involved in antibiotic resistance remain unclear. Efflux pump plays an important role in clinically relevant multidrug resistance. Furthermore, the relationship between the strains with different LVX level-resistances from individuals is also unknown.Helicobacter pylori monoclonal strains were isolated from patients with eradication failure. E test was used to detect the minimal inhibitory concentration of LVX. One lower-level LVX-resistant clone and 2 higher-level LVX-resistant clones from the same patient were selected to sequence the complete genomes. Single-nucleotide variants (SNVs) and mutations were extracted and analyzed from gryA and resistance-nodulation-division family efflux genes.Two clones with higher-level resistance had the mutation pattern of Asn87Lys and one lower-level LVX-resistant clone had an Asp91Asn mutation. Compared to clones with higher-level resistance, the higher genetic variations were found in genes belonging to the resistance-nodulation-division family in H pylori strains with lower-level resistance to LVX. There were significantly more SNVs of Hp0970 (hefE) and Hp1329 (hefI) in the lower-level LVX-resistant clone than those in the higher-level LVX-resistant clones (P = .044).The mutation pattern of the Asn87Lys of the gyrA gene confers a higher resistance to LVX than that of the Asp91Asn in H pylori. Increase in the number of SNVs of the Hp0970 (hefE) and Hp1329 (hefI) genes change the resistance to LVX. Twelve mutations verified by Sanger sequencing in Hp0970 (hefE) and Hp1329 (hefI) may decrease resistant levels to LVX.


Assuntos
Antibacterianos/farmacologia , Farmacorresistência Bacteriana/genética , Infecções por Helicobacter/microbiologia , Helicobacter pylori/genética , Levofloxacino/farmacologia , Mutação/genética , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori/efeitos dos fármacos , Helicobacter pylori/isolamento & purificação , Sequenciamento de Nucleotídeos em Larga Escala , Humanos
13.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 42(3): 313-318, 2020 Jun 30.
Artigo em Chinês | MEDLINE | ID: mdl-32616125

RESUMO

Objective To investigate the effects of Helicobacter pylori(H.pylori)infection on autonomic nervous function and calcitonin gene-related peptide in patients with functional dyspepsia(FD). Methods Thirty-one patients with FD matching Rome Ⅳ criteria were included and divided into H.pylori-positive group and H.pylori-negative group.All patients were evaluated by Symptom Index of Dyspepsia(SID),Nepean Dyspepsia Index(NDI),and Hospital Anxiety and Depression Scale(HADS).Their heart rate variability(HRV)and calcitonin gene-related peptide(CGRP)level were also measured. Results There were no significant differences in SID(Z=-0.858, P=0.858),NDI(Z=-1.464, P=0.143),and Hospital Depression Scale score(Z=0.699, P=0.485).However,the Hospital Anxiety Scale score was significantly higher in H.pylori-positive group than the H.pylori-negative group(Z=-2.470, P=0.014).The level of CGRP in H.pylori-positive group[(0.999±0.274)ng/ml]was significantly higher than that in the H.pylori-negative group[(0.812±0.172)ng/ml;t=2.238, P=0.033].HRV data showed no significant difference between these two groups at very low frequency(t=-1.210, P=0.236),low frequency(LF)(t=0.419, P=0.678),high frequency(HF)(t=0.612, P=0.546),LF/HF(t=-0.882, P=0.399),and total power(t=-0.963, P=0.344). Conclusion In FD patients,patients with H.pylori-positive FD patients have higher depression and CGRP levels than those without H.pylori infection,although their dyspepsia symptoms and HRV show no notable changes.


Assuntos
Dispepsia , Infecções por Helicobacter , Helicobacter pylori , Ansiedade , Calcitonina , Peptídeo Relacionado com Gene de Calcitonina , Humanos
14.
Zhonghua Bing Li Xue Za Zhi ; 49(7): 721-726, 2020 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-32610385

RESUMO

Objective: To study the clinicopathological characteristics and pathologic diagnosis of autoimmune gastritis. Methods: Fourteen biopsies of autoimmune gastritis were collected from January 2018 to March 2019 at Guangdong Provincial People's Hospital. Their clinical data, histological features and immunohistochemical (IHC) results were analyzed, with review of relevant literature. Results: All 14 patients' ages ranged from 41 to 79 years (mean 55 years). There were 12 females and 2 males. All patients had non-specific symptoms, but they all had positive serum anti-parietal cell antibody and/or anti-intrinsic factor antibody. Seven patients had variable degree of anemia. Two patients had concomitant H. pylori infection. Two patients presented with multiple protruding polyps in corpus/fundus, 0.2 to 0.9 cm in diameter, or multiple large lobulated and broad based polyps (0.8 to 3.5 cm in diameters). The former cases were diagnosed as type 1 neuroendocrine tumors, the latter were multiple hyperplastic polyps. Microscopically, autoimmune gastritis showed typical morphology, characterized by diffuse corpus-restricted atrophic gastritis with variable proportions of intestinal metaplasia, or pseudopyloric metaplasia, pancreatic, acinar metaplasia, foveolar hyperplasia and hyperplasia of the endocrine-like cells (ECL cells). Hyperplasia of ECL cells often needed IHC staining to confirm. CgA/Syn IHC stain highlighted linear and micronodular ECL cell hyperplasia. In the absence of concurrent or past H. pylori infection, the antrum was usually normal. Gastrin IHC stain showed hyperplasia of gastrin-producing cells (G cells) in the antrum. Two cases were in the early phase, six were in florid phase, and six were end phase. Conclusions: Most patients of autoimmune gastritis have non-specific symptoms or are asymptomatic and show various endoscopic findings. There are three histologic phases of autoimmune gastritis. Recognition of this entity would be beneficial for pathologists to avoid misdiagnosis. Pathologists can make preferred diagnosis of autoimmune gastritis depending on the histologic clues and prompt appropriate and timely management for the patients.


Assuntos
Doenças Autoimunes , Gastrite , Adulto , Idoso , Celulas Tipo Enterocromafim , Feminino , Mucosa Gástrica , Infecções por Helicobacter , Helicobacter pylori , Humanos , Masculino , Pessoa de Meia-Idade
15.
Life Sci ; 256: 117977, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32603822

RESUMO

AIMS: Silibinin is the major component of flavonolignans complex mixture (Silymarin), which is obtained from Silybum marianum (L.) Gaertn. Despite several reports about silibinin, little is known about its effects on gastric diseases. Then, the present study aims to evaluate the silibinin effect against Helicobacter pylori infection, gastric tumor cells and immunomodulation. MAIN METHODS: The anti-H. pylori effect was performed on 43504 and 43629 strains by minimum inhibitory concentration (MIC) determination, observing morphological alterations by scanning electron microscopy and in silico evaluation by molecular docking. Immunomodulatory activity (Interleukins-6 and 10, TNF-α and NO inhibition) was determined in H. pylori-stimulated macrophages and the cytotoxic activity on gastric adenocarcinoma cells prior and after metabolization by S9 fraction. KEY FINDINGS: Silibinin showed anti-H. pylori activity with MIC of 256 µg/mL, promoted important morphological changes in the bacterial cell wall, as blebs and clusters, suggesting interaction with Penicillin Binding Protein (PBP) subunits. Immunomodulatory potential was observed at 50 µg/mL with the inhibition of produced cytokines and NO by H. pylori-stimulated macrophages of 100% for TNF-ɑ, 56.83% for IL-6, and 70.29% for IL-10 and 73.33% for NO. Moreover, silibinin demonstrated significant cytotoxic activity on adenocarcinoma cells (CI50: 60.17 ± 0.95 µg/mL) with a higher selectivity index (SI: 1.52) compared to cisplatin. After metabolization silibinin showed an increase of cytotoxicity with a CI50 six-fold decrease (10.46 ± 0.25). SIGNIFICANCE: The use of silibinin may become an important alternative tool in the prevention and treatment of H. pylori infection and, consequently, in gastric cancer.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Infecções por Helicobacter/prevenção & controle , Helicobacter pylori/efeitos dos fármacos , Simulação de Acoplamento Molecular/métodos , Silibina/farmacologia , Neoplasias Gástricas/prevenção & controle , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Linhagem Celular Tumoral , Relação Dose-Resposta a Droga , Mucosa Gástrica/efeitos dos fármacos , Mucosa Gástrica/microbiologia , Mucosa Gástrica/patologia , Infecções por Helicobacter/patologia , Helicobacter pylori/fisiologia , Camundongos , Testes de Sensibilidade Microbiana/métodos , Células RAW 264.7 , Silibina/química , Silibina/uso terapêutico , Neoplasias Gástricas/patologia
16.
Arq Gastroenterol ; 57(2): 154-160, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32609157

RESUMO

BACKGROUND: It has been proposed that the combination of gastrin-17 (G-17), pepsinogens I and II (PGI and PGII), and anti-Helicobacter pylori (H. pylori) antibodies (GastroPanel®, BIOHIT HealthCare, Helsinki, Finland) could serve as biomarkers of atrophic gastritis. OBJECTIVE: This study aimed to ensure the diagnostic accuracy of GastroPanel® and evaluate the effect of proton pump inhibitors (PPIs) on these biomarkers. METHODS: Dyspeptic patients who underwent gastrointestinal endoscopy were enrolled in the present study. Histological findings, which were the gold standard to stratify groups, were as follows: no atrophy (controls); antrum atrophy; corpus atrophy; multifocal atrophy; and neoplasia. G-17, PGI, PGII, and anti-H. pylori immunoglobulin (Ig)G antibodies were assayed using commercially available kits. The ratio of PGI/PGII was calculated. RESULTS: Among 308 patients, 159 (51.6%) were PPI users. The overall prevalence of atrophy was 43.8% (n=135). Ninety-two (29.9%) patients were H. pylori positive according to anti-H. pylori IgG levels. G-17 levels were not low in those with antrum atrophy but were high in those with corpus and multifocal atrophies. PGI levels were significantly lower in those with corpus and multifocal atrophies. The sensitivity of PGI <30 µg/L to detect corpus atrophy was 50% (95% CI 27.8-72.1%), with a specificity of 93.2% (95% CI 84.3-97.5%), a positive likelihood ratio of 7.4 (95% CI 2.9-19.2), and a negative likelihood ratio of 0.5 (95% CI 0.3-0.8). A small number of subjects (n=6) exhibited moderate to intense atrophy (4%), among whom 66.7% exhibited decreased PGI levels. PPI significantly increased the levels of G-17 and PGI, except in those with corpus and multifocal atrophies, in whom PGI levels were not increased by PPIs. CONCLUSION: GastroPanel® (Gastrin-17, PGI, and PGI/PGII ratio) did not demonstrate high sensitivity for detecting gastric atrophy.


Assuntos
Gastrite Atrófica/diagnóstico , Inibidores da Bomba de Prótons , Anticorpos Antibacterianos , Brasil , Infecções por Helicobacter , Helicobacter pylori , Humanos
17.
Wiad Lek ; 73(6): 1223-1228, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32723957

RESUMO

OBJECTIVE: The aim: To define clinical peculiarities of chronic active gastritis in patients with type 2 diabetes mellitus (T2DM) considering Helicobacter pylori (HP) status and small intestinal bacterial overgrowth (SIBO). PATIENTS AND METHODS: Materials and methods: 172 patients with chronic active gastritis were enrolled in the study, 92 out of them had concomitant T2DM. Symptoms were collected with the questionnaire, HP infection was diagnosed with stool antigen test, SIBO was assessed with glucose hydrogen breath test. RESULTS: Results: 87.5% (n=70) patients with chronic gastritis without DM had epigastric pain, however those with T2DM reported pain only in 41.3% (n=38) cases. Other symptoms included: nausea, bloating, early satiety, postprandial fullness, heartburn, belching and vomiting. HP infection in patients with chronic gastritis and concomitant T2DM is significantly associated with symptoms of epigastric pain (OR=2.78, 95%CI 0.92-8.41), bloating (OR=3.92, 95%CI 1.40-10.99), nausea (OR=2.32, 95%CI 0.85-0.6.30), postprandial fullness (OR=1.45, 95%CI 0.54-3.87) and belching (OR=1.01, 95%CI 0.32-3.16), whereas SIBO - with bloating (OR=8.82, 95%CI 2.88-27.01), nausea (OR=5.15, 95%CI 1.88-14.10) and belching (OR=2.53, 95%CI 0.67-9.52). CONCLUSION: Conclusions: Patients with T2DM and chronic active gastritis report epigastric pain significantly less than non-diabetics. HP infection probably plays a prominent role in development of epigastric pain in patients with T2DM. Additionally, HP is linked to SIBO, which may lead to bloating, belching and nausea onset.


Assuntos
Diabetes Mellitus Tipo 2 , Dispepsia , Gastrite , Infecções por Helicobacter , Helicobacter pylori , Humanos
19.
Arch. argent. pediatr ; 118(3): e241-e245, jun. 2020. tab
Artigo em Inglês, Espanhol | LILACS, BINACIS | ID: biblio-1104227

RESUMO

Introducción: El Helicobacter pylori (HP) causa inflamación local en el estómago y una respuesta inmunitaria humoral sistémica. En los estudios que investigaron la asociación entre la infección por HP y el índice de neutrófilos/linfocitos (INL) y el volumen plaquetario medio (VPM) en adultos, no se observó ninguna relación. Hasta donde sabemos, no se hicieron estudios en niños. Nuestro objetivo fue evaluar la asociación entre los valores de INL y VPM y la infección por HP, la clasificación de la gravedad y el estado antes y después del tratamiento.Población y métodos: En el estudio se incluyeron pacientes de 2 a 18 años de edad con dispepsia y sin enfermedades crónicas sometidos a una endoscopía alta. Se hizo una biopsia endoscópica de la mucosa y se determinaron la presencia de HP y la gravedad de la infección según la clasificación de Sídney.Resultados: Se incluyeron en el estudio 153 pacientes con HP y 211 sin HP; la media de edad fue de 13,3 ± 3,4 años y 13,1 ± 3,5 años, respectivamente. No se observaron diferencias estadísticamente significativas entre los pacientes con y sin HP ni tampoco entre los subgrupos de pacientes con HP según la gravedad en relación con el INL y el VPM (p > 0,05).Conclusiones: No se observó una asociación entre los valores de INL y VPM y la infección por HP, la clasificación de la gravedad ni el estado antes y después del tratamiento.


Introduction: HP causes local inflammation in the stomach and a systemic humoral immune response. No relationship was found in adult studies investigating the association between HP infection and neutrophil/lymphocyte ratio (NLR) and mean platelet volume (MPV). To our knowledge, there is no study in children. We aimed to evaluate the association between NLR and MPV values with HP infection, severity classification, and pre- and post-treatment status.Population and Methods: Patients with dyspepsia aged between 2-18 years and without any chronic diseases undergoing gastroduodenoscopy were included in the study. Endoscopic mucosal biopsy was performed, HP presence and infection severity were determined according to Sydney Classification.Results: 153 patients with HP positivity and 211 patients with HP negativity were included in the study, the mean age of them was 13.3 ± 3.4 years and 13.1 ± 3.5 years, respectively. No statistically significant difference was found between patients with HP positive and negative patients and also between severity subgroups of HP positive patients in terms of NLR and MPV (p > 0.05).Conclusions:There was no association between NLR and MPV values with HP infection, severity classification, or pre- and post-treatment status.


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Helicobacter pylori , Infecções por Helicobacter , Biópsia , Linfócitos , Estudos Transversais , Endoscopia , Volume Plaquetário Médio , Neutrófilos
20.
J Environ Pathol Toxicol Oncol ; 39(1): 77-88, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32479014

RESUMO

Helicobacter pylori causes a Gram-negative bacterial infection that can increase the risk of gastric cancer. Consequently, meticulous prevention of an H. pylori infection is significant for averting gastric cancer in humans. Nobiletin, an important dietary polymethoxylated flavonoid in citrus fruits, possesses multidimensional pharmaceutical properties, including its ability to act as an anticancer, anti-inflammatory, antioxidative, cardiovascularly defensive, neuroprotective, and antimetabolic agent. Our study evaluates the role of nobiletin in inflammation-mediated gastric carcinogenic signaling of H. pylori-arbitrated coculture in the human gastric epithelial (GES)-1 cell line. Our results show that the culture system of H. pylori-tainted GES-1 cells demonstrates maximum fabrication of reactive oxygen species (ROS), mediating DNA injury and augmenting nuclear fragmentations. Treatment with nobiletin reduces ROS levels and apoptotic morphological changes by dual staining and decreases levels of lipid peroxides and glutathione content in H. pylori-infected GES-1 cells. Phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT)/phosphatase and tensin homolog signaling have been implicated to affect cell endurance, inflammation, proliferation, and carcinogenic activity in gastric GES-1 cells. We find that nobiletin strongly impedes tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, PI3K, AKT, and mitogen-activated protein kinase molecules, including p38, extracellular receptor kinase 1, and c-Jun amino-terminal expression in H. pylori-infected GES-1 cells. We conclude that nobiletin potentially impedes H. pylori infection and its related activation, likely preventing H. pylori infection-mediated gastric cancer.


Assuntos
Antioxidantes/farmacologia , Carcinogênese/efeitos dos fármacos , Flavonas/farmacologia , Infecções por Helicobacter/tratamento farmacológico , Transdução de Sinais/efeitos dos fármacos , Neoplasias Gástricas/tratamento farmacológico , Apoptose/efeitos dos fármacos , Linhagem Celular , Células Epiteliais , Infecções por Helicobacter/microbiologia , Helicobacter pylori/fisiologia , Inflamação/tratamento farmacológico , Proteínas Quinases Ativadas por Mitógeno/metabolismo , Neoplasias Gástricas/microbiologia
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