Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.832
Filtrar
1.
Medicine (Baltimore) ; 99(50): e23587, 2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33327321

RESUMO

RATIONALE: Angiosarcoma is a rare malignant tumors. The objective of this study is to report a patient who suffered from a progressive low back pain and left lower extremities radiation pain for about 8 months, After diagnoses, this was identified as an extremely rare case of primary multiple angiosarcoma of vertebra. PATIENT CONCERNS: A 54-year-old man with a history of 2-year hypertension and 8-year diabetes, both of which were well controlled by drug management. Lately, he suffered from a progressive low back pain and left lower extremities radiation pain for about 8 months. DIAGNOSES: Magnetic resonance imaging of lumbar showed a clear pathological fracture and primary multiple angiosarcoma of all vertebra. Postoperative pathology and High-throughput sequencing confirmed the diagnosis of primary multiple angiosarcoma of vertebra. INTERVENTIONS: The patient underwent minimally invasive pedicle screw fixation combined with bone cement augmentation for the purpose of stabilizing the damaged vertebrae. Following operation, he received both radiotherapy and chemotherapy for a period of time. OUTCOMES: The operation has achieved positive results in relieving pain and stabilizing the spine. No wound problem or operative complications occurred after operation. The patient reported an obvious remission of low back pain and was only capable to perform restricted physiological activities. A long-term palliative radiotherapy and chemotherapy were performed after operation. Unfortunately, the patient died 18 months later. CONCLUSION: This article emphasizes primary multiple angiosarcoma of vertebra. Despite being rare, it should be part of the differential when the patient manifested back pain and radiculopathy. We recommended the minimally invasive pedicle screw fixation for angiosarcoma of vertebra. Osteoplasty by bone cement augmentation was also an ideal choice for surgical treatment. It also advocates the use of specific targeted radiotherapy drugs based on gene analysis of tumors.


Assuntos
Fraturas Espontâneas/diagnóstico , Hemangiossarcoma/diagnóstico , Vértebras Lombares , Neoplasias Primárias Múltiplas/diagnóstico , Neoplasias da Coluna Vertebral/diagnóstico , Terapia Combinada , Fraturas Espontâneas/complicações , Fraturas Espontâneas/diagnóstico por imagem , Fraturas Espontâneas/cirurgia , Hemangiossarcoma/complicações , Hemangiossarcoma/diagnóstico por imagem , Hemangiossarcoma/cirurgia , Humanos , Dor Lombar/etiologia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/complicações , Neoplasias Primárias Múltiplas/diagnóstico por imagem , Neoplasias Primárias Múltiplas/cirurgia , Parafusos Pediculares , Neoplasias da Coluna Vertebral/complicações , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Neoplasias da Coluna Vertebral/cirurgia
3.
Leg Med (Tokyo) ; 47: 101785, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32977197

RESUMO

Splenic angiosarcoma (SA) is a rare disease that can cause spontaneous splenic rupture leading to unexpected death. The rare incidence and non-specific clinical presentations made the early correct diagnosis of SA impossible in clinical practice. Even with medical intervention, 80% of patients died within 6 months after diagnosis. Here, we report a man who had complained of abdominal distension for 2 weeks and succumbed to the disease nine hours after admission. Diagnosis of hepatic and splenic angiosarcomas was based on post-mortem histopathological examination and immunohistochemistry, and the cause of death was hemorrhagic shock caused by spontaneous splenic rupture secondary to SA. This present case was the first forensic autopsy of spontaneous splenic rupture secondary to SA, which can highlight the diagnosis of rare diseases in forensic practice, and forensic pathologists should bear in mind these rare diseases even in routine practice.


Assuntos
Autopsia , Morte Súbita/etiologia , Morte Súbita/patologia , Patologia Legal , Hemangiossarcoma/complicações , Hemangiossarcoma/diagnóstico , Neoplasias Esplênicas/complicações , Neoplasias Esplênicas/diagnóstico , Ruptura Esplênica/etiologia , Adulto , Evolução Fatal , Hemangiossarcoma/patologia , Humanos , Masculino , Doenças Raras , Ruptura Espontânea , Choque Hemorrágico/etiologia , Neoplasias Esplênicas/patologia
5.
World Neurosurg ; 139: 232-237, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32330618

RESUMO

BACKGROUND: Cerebral angiosarcoma is an extremely rare malignant tumor that originates from vascular endothelial cells of the brain or meninges. Especially, primary brainstem angiosarcoma has not been reported. CASE DESCRIPTION: A 64-year-old man presented with left subjective weakness, hypesthesia, and dizziness. Brain imaging showed a multistage hemorrhagic mass in the right dorsal pons, which was initially misdiagnosed as a cavernous malformation. The patient's neurologic status suddenly deteriorated over a few months, and the mass grew rapidly. Surgical resection was performed, and the final pathology showed brainstem angiosarcoma. CONCLUSIONS: To our knowledge, this is the first case of brainstem angiosarcoma confirmed by pathology after surgical resection. This report highlights that clinicians need to consider angiosarcoma as part of the differential diagnosis for rare hemorrhagic lesions in the brainstem when both imaging findings and neurologic deterioration indicate rapid progression.


Assuntos
Neoplasias do Tronco Encefálico/diagnóstico , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico , Hemangiossarcoma/diagnóstico , Neoplasias do Tronco Encefálico/patologia , Erros de Diagnóstico , Hemangiossarcoma/patologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neuroimagem/métodos , Tomografia Computadorizada por Raios X
8.
Indian J Pathol Microbiol ; 63(Supplement): S94-S97, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32108638

RESUMO

Primary uterine angiosarcoma is a very rare malignant tumor in the female genital tract and only 23 cases have been previously reported in the literature. It is often clinically misrecognized as another disease due to its low incidence. In this report, we present a new case of a 78-year-old woman diagnosed on histopathologic observation and immunohistochemical staining. Additionally, available studies are collected and reviewed to summarize the clinical and pathological characteristics of primary uterine angiosarcoma to remind gynecologists and pathologists of this rare disease when they encounter such cases.


Assuntos
Hemangiossarcoma/diagnóstico , Neoplasias Uterinas/diagnóstico , Útero/patologia , Idoso , China , Feminino , Humanos , Imuno-Histoquímica , Útero/citologia
10.
Head Neck Pathol ; 14(1): 109-120, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31950467

RESUMO

This manuscript provides an overview of pleomorphic spindle cell tumors presenting on sun-damaged skin of the elderly and includes discussions of atypical fibroxanthoma, pleomorphic dermal sarcoma, spindle cell and metaplastic squamous cell carcinoma, spindle cell and dedifferentiated melanoma and poorly differentiated cutaneous angiosarcoma. These tumors share many of the clinical presenting and histological features, making confident diagnosis challenging. A reliable and robust diagnosis is necessary to predict behavior as the biologic potential of these tumors ranges from benign (e.g. atypical fibroxanthoma) to outright malignant with poor survival rates (e.g. cutaneous angiosarcoma). The salient clinical, histologic and immunohistochemical characteristics are discussed in detail with emphasis on distinguishing features and differential diagnosis to provide the reader with a better understanding of these entities and helpful clues for a more robust diagnosis.


Assuntos
Carcinoma de Células Escamosas/patologia , Fibroma/patologia , Hemangiossarcoma/patologia , Melanoma/patologia , Sarcoma/patologia , Neoplasias Cutâneas/patologia , Carcinoma de Células Escamosas/diagnóstico , Fibroma/diagnóstico , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/patologia , Hemangiossarcoma/diagnóstico , Humanos , Melanoma/diagnóstico , Sarcoma/diagnóstico , Neoplasias Cutâneas/diagnóstico
11.
BMC Cancer ; 20(1): 13, 2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-31906980

RESUMO

BACKGROUND: Primary angiosarcomas of the right atrium are extremely rare, often resulted in missed diagnosis or misdiagnosis with routine examination tools. These malignant cardiac tumors are highly aggressive with generally poor prognosis. Surgical excision is the mainstay of treatment as it is essentially not responsive to current regimens of chemoradiotherapy. CASE PRESENTATION: Herein, we describe a patient who initially presented with paroxysmal atrial fibrillation and was subsequently treated with radiofrequency catheter ablation (RFCA). Prior to RFCA, an initial transesophageal echocardiography revealed a local thickening of the intratrial septum. Three months later, she was hospitalized with progressive dyspnea and massive pericardial effusion. A large immobile, non-pedunculated mass, occupying almost half of the right atrium was detected by transthoracic and transesophageal echocardiogram. Multimodality cardiac imaging was useful in further characterizing this mass, which was ultimately diagnosed as an angiosarcoma based upon biopsy results. The growth rate was extremely rapid following RFCA, and patient underwent surgical excision. After discharge, the angiosarcoma recurred and patient survived for 7 months from the first episode of tamponade. CONCLUSIONS: Primary cardiac angiosarcoma of the right atrium can easily be mistaken for structural anomalies in its early stages, losing the opportunity for initiating earlier treatments to improve potential patient outcomes. The correct diagnosis of this rare case relied on the comprehensive utilization of multimodal imaging techniques including biopsy.


Assuntos
Ablação por Cateter , Átrios do Coração , Neoplasias Cardíacas/diagnóstico , Hemangiossarcoma/diagnóstico , Diagnóstico Ausente , Fibrilação Atrial/diagnóstico , Dispneia/diagnóstico , Dispneia/etiologia , Evolução Fatal , Feminino , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Hemangiossarcoma/diagnóstico por imagem , Hemangiossarcoma/patologia , Hemangiossarcoma/cirurgia , Humanos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Derrame Pericárdico/diagnóstico , Tomografia por Emissão de Pósitrons
12.
Arch Pathol Lab Med ; 144(2): 240-244, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-30958692

RESUMO

Anastomosing hemangioma is a rare neoplastic vascular lesion, histologically mimicking angiosarcoma. It is predominantly composed of irregularly anastomosing sinusoidal-like spaces lined by endothelial cells with minimal atypia, a frequently hobnail morphology, and minimally invasive margins. Since its original description in the genitourinary system, an increasing number of anastomosing hemangiomas have been reported, localized deep in the body in various organs, always with similar histologic features. It is more frequently asymptomatic, often discovered incidentally by imaging studies, owing to coexisting benign or malignant tumors. In renal cases, the most frequent clinical context is end-stage renal disease. There is overwhelming evidence of the benign nature of the lesion and an accurate diagnosis could prevent overtreatment. The differential diagnosis includes other benign vascular tumors, well-differentiated angiosarcoma, Kaposi sarcoma, and other vascular-rich neoplasms. We review the clinical and histopathologic characteristics of this peculiar lesion with an emphasis on the differential diagnosis.


Assuntos
Hemangioma/patologia , Hemangiossarcoma/patologia , Neoplasias Renais/patologia , Diagnóstico Diferencial , Hemangioma/diagnóstico , Hemangiossarcoma/diagnóstico , Humanos , Neoplasias Renais/diagnóstico
13.
Am J Surg Pathol ; 44(2): 271-279, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31688141

RESUMO

We report 21 cases of a distinctive and unique vascular tumor which we propose to be a pure lymphatic-type angiosarcoma characterized by architectural and growth characteristics of angiosarcoma, cytologic, and immunohistochemical features of lymphatic differentiation, a prominent lymphocytic infiltrate, and variable nuclear grade. Patients included 12 males and 9 females with a median age of 65 years (range: 32 to 95 y). Tumors involved the head and neck (n=11), lower extremities (n=5), trunk (n=4), and upper extremity (n=1) and were located superficially in the dermis and/or subcutis. Tumors were designated "low grade" (n=10) when the nuclear grade was low, and vascular channel formation was evident throughout but with multilayering of endothelium within the vessels. Cases were designated "high grade" (n=11) when nuclei appeared higher grade with more rounded contours and prominent nucleoli and when solid areas predominated over vascular channel formation. A striking feature of both groups was the presence of a dense, lymphocytic infiltrate with occasional germinal center formation. All cases strongly and diffusely expressed at least 1 lymphatic marker (21/21) with podoplanin (17/19) and Prox-1 (11/11) more commonly expressed than LYVE-1 (5/10). No consistent molecular alteration was identified. Follow-up on 17 patients (median: 41 mo, mean: 54 mo) showed 10 patients were alive without disease, 5 were alive with disease, 1 died of other cause, and 1 died of disease. Local recurrence developed in 9 cases and metastasis in 2 cases, although neither correlated with grade as defined. On the basis of clinical follow-up to date, the natural history of lymphatic-type angiosarcoma appears to be more favorable than other forms of cutaneous angiosarcoma.


Assuntos
Hemangioendotelioma/patologia , Hemangiossarcoma/patologia , Linfangiossarcoma/patologia , Neoplasias Cutâneas/patologia , Neoplasias de Tecidos Moles/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Feminino , Seguimentos , Hemangioendotelioma/diagnóstico , Hemangioendotelioma/mortalidade , Hemangiossarcoma/diagnóstico , Hemangiossarcoma/mortalidade , Humanos , Linfangiossarcoma/diagnóstico , Linfangiossarcoma/mortalidade , Vasos Linfáticos/patologia , Linfócitos/metabolismo , Masculino , Pessoa de Meia-Idade , Prognóstico , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/mortalidade , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/mortalidade , Análise de Sobrevida
14.
Int J Gynecol Pathol ; 39(1): 97-102, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31815894

RESUMO

Angiosarcomas of the female genital tract are rare and primary angiosarcoma of the cervix is extremely rare with only one prior case report. We report a case of a primary cervical angiosarcoma in a 43-yr-old woman who presented with heavy vaginal bleeding. Cervical biopsy and subsequent radical hysterectomy showed a malignant vascular tumor which was composed of spindled and epithelioid cells and formed abortive vascular channels. Immunohistochemically, the tumor cells were diffusely positive for CD31, CD34, ERG, and cyclin D1 and focally positive for D2-40. A reverse transcription polymerase chain reaction test for YWHAE-NUTM2 genetic fusion was negative excluding a YWHAE-translocated high-grade endometrial stromal sarcoma. The tumor formed a 5 cm mass within the cervix with microscopic involvement of the endometrium, superficial myometrium, and vagina. Metastatic microscopic tumor deposits were present in both ovaries, left fallopian tube, one paracervical lymph node, and one pelvic lymph node. In reporting this unusual case we discuss the differential diagnosis.


Assuntos
Hemangiossarcoma/diagnóstico , Hemangiossarcoma/patologia , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/patologia , Adulto , Diagnóstico Diferencial , Neoplasias do Endométrio/diagnóstico , Neoplasias do Endométrio/patologia , Feminino , Humanos , Imuno-Histoquímica , Metástase Neoplásica , Sarcoma do Estroma Endometrial/diagnóstico , Sarcoma do Estroma Endometrial/patologia
18.
G Ital Cardiol (Rome) ; 20(11): 664-667, 2019 Nov.
Artigo em Italiano | MEDLINE | ID: mdl-31697274

RESUMO

Cardiac sarcoma is the commonest histology among primary cardiac tumors but it is a rare clinical entity and it is characterized by late stage presentation, poor prognosis from the time of detection and a variety of clinical presentations depending on the size and extent of the mass. We report the case of a high-grade right atrial angiosarcoma presenting with pulmonary embolism and cardiac tamponade. The patient underwent surgical resection and reconstruction of the atrial wall with bovine pericardial patch. This case report underscores the great heterogeneity of the clinical presentation, often non-specific, and the fatal prognosis of angiosarcoma, mostly related to the lack of evidence supporting a standardized therapeutic approach.


Assuntos
Tamponamento Cardíaco/etiologia , Neoplasias Cardíacas/diagnóstico , Hemangiossarcoma/diagnóstico , Embolia Pulmonar/etiologia , Idoso , Feminino , Átrios do Coração/patologia , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Hemangiossarcoma/patologia , Hemangiossarcoma/cirurgia , Humanos
19.
J Coll Physicians Surg Pak ; 29(12): S132-S134, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31779767

RESUMO

Angiosarcomas constitute less than 1% of primary bone malignancies. Their association with prosthetic material has been described, while their etiology remains unclear. We present a case of a 64-year woman with severe bleeding and hip joint osteolysis after an accidental fall. She had undergone prosthetic total hip arthroplasty many years back. The rapid recurrence of pelvic hematoma and the refractory infection of pelvic cavity made necessary to disarticulate the prosthetic hip joint, after several attempts to apply conservative treatment. Despite supportive treatment, she died. Autopsy revealed evidently dissemanted angiosarcoma of pelvic bones. Angiosarcoma of the bone should be considered in the differential diagnosis of patients with uncontrollable bleeding and osteolysis, due to the increase of life expectancy when prompt and combined treatment is initiated.


Assuntos
Artroplastia de Quadril/efeitos adversos , Neoplasias Ósseas/etiologia , Hemangiossarcoma/etiologia , Prótese de Quadril/efeitos adversos , Ossos Pélvicos , Biópsia , Neoplasias Ósseas/diagnóstico , Evolução Fatal , Feminino , Hemangiossarcoma/diagnóstico , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Falha de Prótese , Tomografia Computadorizada por Raios X
20.
Pan Afr Med J ; 33: 327, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692820

RESUMO

Primary angiosarcoma of the pleura is an extremely rare tumour arising from arterial or venous pulmonary vessels of various size. It is characterized by an aggressive course and a poor prognosis. The early diagnosis is challenging due to diverse clinical and radiological manifestations. We report a case of a 70 year old male with primary right pleural epitheloid angiosarcoma. The patient had a history of a two week's progressive dyspnea. CT-scan showed a prominent thikening of the right pleura associated with pleural effusion and atelectasis. CT-scan guided by biopsy was performed and histological examination showed a tumor proliferation consisting of sheets of polygonal and epitheloid cells showing rudimentary vascular differentiation. Immunohistochemically, tumor cells were strongly positive for CD31 and Factor VIII-related antigen, negative for CD34, weakly and focally positive for EMA and Cytokeratine. The overall pathological and immunohistochemical features of the pleural specimens supported the diagnosis of epitheloid angiosarcma. The patient died after a week of discharge by pulsless ventricular tachycardia arrest. In addition, we also present a brief litterature review on pleural angiosarcoma. Our experience with this case suggests that comprehensive and sufficient sample collection and meticulous histological examination aided with immunohistochemical stains, particulary the endothelial markers, are required for accurate diagnosis of this rare malignancy.


Assuntos
Hemangiossarcoma/diagnóstico , Neoplasias Pleurais/diagnóstico , Tomografia Computadorizada por Raios X/métodos , Idoso , Biópsia , Hemangiossarcoma/patologia , Humanos , Masculino , Neoplasias Pleurais/patologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA