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1.
Recurso na Internet em Inglês, Espanhol, Português | LIS - Localizador de Informação em Saúde | ID: lis-48770

RESUMO

Em 15 de abril de 2022, a Organização Mundial da Saúde (OMS) publicou um alerta sobre casos de hepatite aguda grave de causa desconhecida em crianças no Reino Unido. Desde então, mais casos foram notificados.


Assuntos
Hepatite/etiologia , Criança
2.
Front Public Health ; 10: 862497, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35493354

RESUMO

Background and Objective: Viral hepatitis is a major public health concern on a global scale. It predominantly affects the world's least developed countries. The most endemic regions are resource constrained, with a low human development index. Chronic hepatitis can lead to cirrhosis, liver failure, cancer and eventually death. Early diagnosis and treatment of hepatitis infection can help to reduce disease burden and transmission to those at risk of infection or reinfection. Screening is critical for meeting the WHO's 2030 targets. Consequently, automated systems for the reliable prediction of hepatitis illness. When applied to the prediction of hepatitis using imbalanced datasets from testing, machine learning (ML) classifiers and known methodologies for encoding categorical data have demonstrated a wide range of unexpected results. Early research also made use of an artificial neural network to identify features without first gaining a thorough understanding of the sequence data. Methods: To help in accurate binary classification of diagnosis (survivability or mortality) in patients with severe hepatitis, this paper suggests a deep learning-based decision support system (DSS) that makes use of bidirectional long/short-term memory (BiLSTM). Balanced data was utilized to predict hepatitis using the BiLSTM model. Results: In contrast to previous investigations, the trial results of this suggested model were encouraging: 95.08% accuracy, 94% precision, 93% recall, and a 93% F1-score. Conclusions: In the field of hepatitis detection, the use of a BiLSTM model for classification is better than current methods by a significant margin in terms of improved accuracy.


Assuntos
Algoritmos , Hepatite , Humanos , Aprendizado de Máquina , Redes Neurais de Computação , Saúde Pública
3.
Dermatol Online J ; 28(1)2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35499416

RESUMO

Targeted therapy (BRAF/MEK inhibitors) is frequently employed in the treatment of metastatic melanoma following immune checkpoint inhibitor therapy inefficacy or intolerance. Although BRAF inhibitors are commonly associated with cutaneous eruptions, they rarely cause severe cutaneous adverse drug reactions such as drug-induced hypersensitivity syndrome (DIHS). Drug-induced hypersensitivity syndrome is a severe drug reaction characterized by extensive eruption often seen in conjunction with fever, facial edema, lymphadenopathy, eosinophilia, atypical lymphocytosis, and variable visceral organ injury characteristically beginning 2-8 weeks after initiating the causative drug. We report a case of atypical DIHS with reduced latency, mucosal involvement, lymphopenia, normal eosinophils, and no lymphadenopathy that occurred secondary to vemurafenib and cobimetinib therapy following melanoma progression while on pembrolizumab. Previous immune checkpoint inhibitor therapy has been associated with atypical DIHS in patients on BRAF/MEK inhibitors. Early recognition of the atypical clinical features of this hypersensitivity reaction is important so that drug discontinuation and corticosteroids can be initiated early.


Assuntos
Síndrome de Hipersensibilidade a Medicamentos , Hepatite , Linfopenia , Melanoma , Neoplasias Cutâneas , Síndrome de Hipersensibilidade a Medicamentos/tratamento farmacológico , Síndrome de Hipersensibilidade a Medicamentos/etiologia , Eosinófilos/patologia , Hepatite/tratamento farmacológico , Humanos , Inibidores de Checkpoint Imunológico , Linfopenia/induzido quimicamente , Linfopenia/tratamento farmacológico , Melanoma/patologia , Quinases de Proteína Quinase Ativadas por Mitógeno/uso terapêutico , Inibidores de Proteínas Quinases/efeitos adversos , Proteínas Proto-Oncogênicas B-raf , Neoplasias Cutâneas/patologia
4.
MMWR Morb Mortal Wkly Rep ; 71(18): 638-640, 2022 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-35511732

RESUMO

During October-November 2021, clinicians at a children's hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. In November 2021, hospital clinicians, the Alabama Department of Public Health, the Jefferson County Department of Health, and CDC began an investigation. This activity was reviewed by CDC and conducted consistent with applicable federal law and CDC policy.


Assuntos
Infecções por Adenoviridae , Hepatite , Doença Aguda , Alabama/epidemiologia , Criança , Humanos , Saúde Pública
7.
Lancet ; 399(10337): 1765, 2022 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-35526541

Assuntos
Hepatite , Humanos
9.
Front Immunol ; 13: 824385, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35529851

RESUMO

Excessive activation and recruitment of neutrophils are generally considered to be associated with pathological aggravation of multiple diseases. However, as the role of neutrophils in tissue injury repair is receiving increasing attention, it is necessary to further explore the beneficial role of activated neutrophils in promoting the resolution of inflammation after injury. In this study, we found that activated neutrophils have a crucial function in suppressing liver inflammation. In methionine-choline-deficient and high-fat (MCDHF) diet induced liver inflammation in mice, tail vein injection of activated neutrophils (A-Neu, stimulated by sphingosine 1-phosphate) inhibited the expressions of pro-inflammatory cytokines in the liver, including C-C chemokine motif ligand 4, tumor necrosis factor and nitric oxide synthase 2, and attenuated liver injury. However, non-activated neutrophils (N-Neu) did not have these effects. In vitro, pro-inflammatory macrophages were co-cultured with N-Neu or A-Neu by transwell, respectively. A-Neu was found to suppress the pro-inflammatory phenotype of macrophages by using RT-qPCR, western blot and cytometric bead array. Microarray analysis showed that there were systematic variations in transcript expression levels between N-Neu and A-Neu. GeneVenn software was used to show the gene expression overlap between GO terms including Regulation of Cell Communication, Cytokine Secretion, Inflammatory Response and Extracellular Space clusters. We identified that Chitinase-like 1 (CHIL1) secreted by S1P activated neutrophils may be an important mediators affecting the pro-inflammatory macrophage responses. In the injured liver of mice induced by MCDHF diet, the expression of Chil1 mRNA increased and was positively correlated with the neutrophil marker Ly6g. Moreover, the secretion of CHIL1 in A-Neu increased significantly. Strikingly, the effect of A-Neu on macrophage response was reproduced by incubating pro-inflammatory macrophages with recombinant CHIL1. A-Neu conditioned medium were incubated with CHIL1 antibody-conjugated protein G beads, magnetically separated to immunodepletion CHIL1 from the A-Neu supernatant, which can partially weaken its inhibitory effect of A-Neu on the production of macrophage pro-inflammatory cytokines. Together, the conclusions indicated that A-Neu could inhibit the pro-inflammatory macrophage responses by secreting CHIL1, thereby effectively inhibiting liver inflammation.


Assuntos
Quitinases , Hepatite , Animais , Quitinases/metabolismo , Citocinas/metabolismo , Hepatite/metabolismo , Inflamação/metabolismo , Macrófagos/metabolismo , Camundongos , Neutrófilos/metabolismo
10.
BMJ ; 377: o982, 2022 04 14.
Artigo em Inglês | MEDLINE | ID: mdl-35422430
11.
BMJ ; 377: o1067, 2022 04 26.
Artigo em Inglês | MEDLINE | ID: mdl-35473749
12.
Cell Mol Life Sci ; 79(5): 265, 2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35484438

RESUMO

Alcoholic pancreatitis and hepatitis are frequent, potentially lethal diseases with limited treatment options. Our previous study reported that the expression of CFTR Cl- channel is impaired by ethanol in pancreatic ductal cells leading to more severe alcohol-induced pancreatitis. In addition to determining epithelial ion secretion, CFTR has multiple interactions with other proteins, which may influence intracellular Ca2+ signaling. Thus, we aimed to investigate the impact of ethanol-mediated CFTR damage on intracellular Ca2+ homeostasis in pancreatic ductal epithelial cells and cholangiocytes. Human and mouse pancreas and liver samples and organoids were used to study ion secretion, intracellular signaling, protein expression and interaction. The effect of PMCA4 inhibition was analyzed in a mouse model of alcohol-induced pancreatitis. The decreased CFTR expression impaired PMCA function and resulted in sustained intracellular Ca2+ elevation in ethanol-treated and mouse and human pancreatic organoids. Liver samples derived from alcoholic hepatitis patients and ethanol-treated mouse liver organoids showed decreased CFTR expression and function, and impaired PMCA4 activity. PMCA4 co-localizes and physically interacts with CFTR on the apical membrane of polarized epithelial cells, where CFTR-dependent calmodulin recruitment determines PMCA4 activity. The sustained intracellular Ca2+ elevation in the absence of CFTR inhibited mitochondrial function and was accompanied with increased apoptosis in pancreatic epithelial cells and PMCA4 inhibition increased the severity of alcohol-induced AP in mice. Our results suggest that improving Ca2+ extrusion in epithelial cells may be a potential novel therapeutic approach to protect the exocrine pancreatic function in alcoholic pancreatitis and prevent the development of cholestasis in alcoholic hepatitis.


Assuntos
Hepatite Alcoólica , Hepatite , Pancreatite Alcoólica , Animais , Regulador de Condutância Transmembrana em Fibrose Cística/genética , Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo , Células Epiteliais/metabolismo , Etanol/toxicidade , Hepatite/metabolismo , Hepatite Alcoólica/genética , Hepatite Alcoólica/metabolismo , Humanos , Camundongos , Pancreatite Alcoólica/metabolismo
13.
PLoS One ; 17(4): e0265660, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35417459

RESUMO

BACKGROUND: Precise incidence prediction of Hepatitis infectious disease is critical for early prevention and better government strategic planning. In this paper, we presented different prediction models using deep learning methods based on the monthly incidence of Hepatitis through a national public health surveillance system in China mainland. METHODS: We assessed and compared the performance of three deep learning methods, namely, Long Short-Term Memory (LSTM) prediction model, Recurrent Neural Network (RNN) prediction model, and Back Propagation Neural Network (BPNN) prediction model. The data collected from 2005 to 2018 were used for the training and prediction model, while the data are split via 5-Fold cross-validation. The performance was evaluated based on three metrics: mean square error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE). RESULTS: Among the year 2005-2018, 20,924,951 cases and 11,892 deaths were supervised in the system. Hepatitis B (HB) is the most disease-causing incidence and death, and the proportion is greater than 70 percent, while the percentage of the incidence and deaths is decreased much in 2018 compared with 2005. Based on the measured errors and the visualization of the three neural networks, there is no one model predicting the incidence cases that can be completely superior to other models. When predicting the number of incidence cases for HB, the performance ranking of the three models from high to low is LSTM, BPNN, RNN, while it is LSTM, RNN, BPNN for Hepatitis C (HC). while the MAE, MSE and MAPE of the LSTM model for HB, HC are 3.84*10-06, 3.08*10-11, 4.981, 8.84*10-06, 1.98*10-12,5.8519, respectively. CONCLUSIONS: The deep learning time series predictive models show their significance to forecast the Hepatitis incidence and have the potential to assist the decision-makers in making efficient decisions for the early detection of the disease incidents, which would significantly promote Hepatitis disease control and management.


Assuntos
Aprendizado Profundo , Hepatite , China/epidemiologia , Previsões , Humanos , Incidência , Fatores de Tempo
14.
Int J Prison Health ; 18(1): 66-82, 2022 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-35401772

RESUMO

Purpose: People in prison are at a higher risk of preventable mortality from infectious disease such as HIV/AIDS, HBV, HCV and TB than those in the community. The extent of infectious disease-related mortality within the prison setting remains unclear. Our aim was to collate available information on infectious disease-related mortality, including the number of deaths and calculate the person-time death rate. Design/Methodology/Approach: We searched databases between 1 Jan 2000 and 18 Nov 2020 for studies reporting HIV, HBV, HCV, TB and/or HIV/TB-related deaths among people in prison. Findings: We identified 78 publications drawn from seven UNAIDS regions encompassing 33 countries and reporting on 6,568 deaths in prison over a 20-year period. HIV/AIDS (n=3,305) was associated with the highest number of deaths, followed by TB (n=2,892), HCV (n=189), HIV/TB (n=173), and HBV (n=9). Due to the limitations of the available published data, it was not possible to meta-analyse or in any other way synthesise the available evidence. Originality/Value: To our best knowledge, this is the first scoping review focused on deaths due to these infections among people in prison internationally. The gaps identified form recommendations to improve the future collection and reporting of prison mortality data. Research implications: To inform targeted efforts to reduce mortality, there is a need for more, better quality data to understand infectious disease-related mortality in custodial settings. Increased investment in the prevention and management of infectious diseases in custodial settings, and in documenting infectious disease-related deaths in prison, is warranted and will yield public health benefits.


Assuntos
Síndrome de Imunodeficiência Adquirida , Doenças Transmissíveis , Infecções por HIV , Hepatite A , Hepatite C , Hepatite , Prisioneiros , Tuberculose , Hepatite C/epidemiologia , Humanos
15.
Sci Rep ; 12(1): 3669, 2022 03 07.
Artigo em Inglês | MEDLINE | ID: mdl-35256688

RESUMO

It has been reported that various kinds of immune checkpoint inhibitors (iCIs) could induce immune-related liver damage. We should focus on the programmed cell death-receptor-1 (PD-1) antibody and non-small cell lung cancer (NSCLC) to analyze the characteristics of hepatitis related to iCIs and find factors that could be useful biomarkers for the diagnosis. A single-center retrospective study of 252 NSCLC patients who received PD-1 antibody (nivolumab or pembrolizumab). Some of the biochemical markers and immunological markers were analyzed during PD-1-antibody treatment with or without ALT elevation. Histopathological features were reviewed by a single expert of hepatic pathology focusing on the following features: fibrosis, portal inflammation, lobular inflammation, lobular necrosis. The formation of macro- and micro-granulomas was also evaluated. The frequency of liver damage induced by nivolumab including grade 1 to 4 (ALT) was 41.9% (78/186 patients). The positive rate of anti-nuclear antibody in the nivolumab group with iCIs-related hepatitis was significantly higher than that in the nivolumab group without iCIs-related hepatitis (p = 0.00112). Granulomatous changes were significantly increased in patients with iCIs-related hepatitis compared with DILI and AIH patients (p < 0.05). The ratios of inflammatory cells CD4/CD8, and CD138/CD3 in ICIs-related hepatitis were significantly lower than those in AIH or DILI patients (p < 0.05). We demonstrated that the pre-existing ANA and characteristic liver histology including CD8+ cells dominancy and granulomatous hepatitis could be biomarkers for the diagnosis of iCIs-related hepatitis in the NSCLC with anti-PD-1 therapy.


Assuntos
Carcinoma Pulmonar de Células não Pequenas , Hepatite A , Hepatite , Neoplasias Pulmonares , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/patologia , Granuloma/induzido quimicamente , Hepatite/patologia , Humanos , Inflamação , Neoplasias Pulmonares/patologia , Nivolumabe/efeitos adversos , Receptor de Morte Celular Programada 1 , Estudos Retrospectivos
16.
J Ethnopharmacol ; 292: 115223, 2022 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-35354089

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Cucurbitacins are highly oxygenated tetracyclic triterpenoids, that represent the major metabolites reported from C. colocynthis (L.) Schrad.. Cucurbitacin E glucoside (CuE) is a tetracyclic triterpene glycoside separated from Cucurbitaceae plants. CuE has potent anti-inflammatory, immunomodulatory, and anti-tumor properties. AIM OF THE STUDY: The current study aimed at examining the hepatoprotective effect of CuE against concanavalin A (Con A)-produced hepatitis. MATERIALS AND METHODS: Mice were intravenously administered Con A (15 mg/kg) to induce AIH. CuE was orally administered at two different doses for five days preceding Con A injection. RESULTS: The results revealed that CuE pretreatment markedly attenuated the serum indices of hepatotoxicity and the severity of hepatic lesions. CuE depressed Con A-provoked increment in CD4+ T-cells in hepatic tissue. The antioxidant activity of CuE was evident through its ability to decrease markers of Con A-induced oxidative stress (malondialdehyde, 4-hydroxyenonanal, and protein carbonyl) and intensified the antioxidants in the hepatic tissue (SOD, GSH, and TAC). CuE increased mRNA expression of SIRT1 and Nrf2 as well as its binding capacity. Subsequently, CuE augmented mRNA expression of Nrf2 targeted genes as NQO1, GCL, and HO-1 and recovered its normal level. CuE inhibited the activation of NF-κB/downstream pro-inflammatory mediators signaling. Furthermore, CuE attenuated the mRNA expression of NLRP3 and its associated genes. CONCLUSION: Collectively, these results demonstrated the remarkable hepatoprotective potential of CuE towards Con A-induced AIH which was mediated via suppression of oxidative stress, enhancing SIRT1/Nrf2/HO-1, and prohibition of the NF-κB/NLRP3 signaling. CuE could be a candidate for hepatitis patients.


Assuntos
Hepatite , Triterpenos , Animais , Antioxidantes/metabolismo , Antioxidantes/farmacologia , Antioxidantes/uso terapêutico , Concanavalina A/metabolismo , Concanavalina A/farmacologia , Glucosídeos/farmacologia , Humanos , Camundongos , Fator 2 Relacionado a NF-E2/genética , Fator 2 Relacionado a NF-E2/metabolismo , NF-kappa B/metabolismo , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Estresse Oxidativo , RNA Mensageiro/metabolismo , Transdução de Sinais , Sirtuína 1/genética , Sirtuína 1/metabolismo , Triterpenos/química , Triterpenos/farmacologia , Triterpenos/uso terapêutico
17.
Int J Mol Sci ; 23(5)2022 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-35269799

RESUMO

Interventions affecting gastrointestinal (GI) physiology suggest that the GI tract plays an important role in modulating the uptake of ingested glucose by body tissues. We aimed at validating the use of positron emission tomography (PET) with oral 18FDG administration in mice, and to examine GI effects on glucose metabolism in adipose tissues, brain, heart, muscle, and liver, and interfering actions of oral lipid co-administration. We performed sequential whole-body PET studies in 3 groups of 10 mice, receiving i.p. glucose and 18FDG or oral glucose and 18FDG ± lipids, to measure tissue glucose uptake (GU) and GI transit, and compute the absorption lumped constant (LCa) as ratio of oral 18FDG-to-glucose incremental blood levels. GI and liver histology and circulating hormones were tested to generate explanatory hypothesis. Median LCa was 1.18, constant over time and not significantly affected by lipid co-ingestion. Compared to the i.p. route, the oral route (GI effect) resulted in lower GU rates in adipose tissues and brain, and a greater steatohepatitis score (+17%, p = 0.03). Lipid co-administration accelerated GI transit, in relation to the suppression in GIP, GLP1, glucagon, PP, and PYY (GI motility regulators), abolishing GI effects on subcutaneous fat GU. Duodenal crypt size, gastric wall 18FDG uptake, and macro-vesicular steatosis were inversely related to adipose tissue GU, and positively associated with liver GU. We conclude that 18FDG-PET is a suitable tool to examine the role of the GI tract on glucose transit, absorption, and bio-distribution. The GI effect consists in the suppression of glucose metabolism selectively in organs responsible for energy intake and storage, and is blunted by lipid ingestion. Modulation of gut and liver inflammation, as reflected by high GU, may be involved in the acute signalling of the energy status.


Assuntos
Fluordesoxiglucose F18 , Hepatite , Tecido Adiposo/diagnóstico por imagem , Tecido Adiposo/metabolismo , Animais , Encéfalo/diagnóstico por imagem , Encéfalo/metabolismo , Fluordesoxiglucose F18/metabolismo , Glucose/metabolismo , Hepatite/metabolismo , Inflamação/diagnóstico por imagem , Inflamação/metabolismo , Lipídeos , Camundongos , Tomografia por Emissão de Pósitrons
18.
BMJ Case Rep ; 15(3)2022 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-35318201

RESUMO

Hepatitis-associated aplastic anaemia (HAAA) is a rare condition characterised by onset of acute hepatitis which is followed by development of severe pancytopenia due to bone marrow failure within 6 months. This syndrome can be precipitated by acute viral infections, but the aetiology remains unknown in the majority. Drug-induced HAAA is extremely rare and has been reported with nutritional and dietary supplements in current literature. We report the first cases of ayurvedic herbal and homeopathic remedies-associated HAAA in two patients which proved fatal in both. Evaluation of patients with acute hepatitis and severe pancytopenia must include a detailed evaluation for complementary and alternative medicine use.


Assuntos
Anemia Aplástica , Doença Hepática Induzida por Substâncias e Drogas , Gymnema sylvestre , Hepatite , Materia Medica , Anemia Aplástica/induzido quimicamente , Anemia Aplástica/terapia , Doença Hepática Induzida por Substâncias e Drogas/complicações , Doença Hepática Induzida por Substâncias e Drogas/terapia , Hepatite/complicações , Humanos , Materia Medica/efeitos adversos
19.
Artigo em Espanhol | PAHO-IRIS | ID: phr-55837

RESUMO

[RESUMEN]. Objetivo. Identificar publicaciones realizadas entre los años 2000 y 2020 sobre hepatitis B en indígenas de América Latina, con el fin de conocer avances y vacíos en el tema durante los últimos 20 años. Métodos. Revisión exploratoria y síntesis rápida de la evidencia. El proceso de organización documental se realizó con los programas Excel® y Rayyan®. Resultados. Se seleccionaron 30 de 107 artículos encontrados, 17 corresponden a estudios epidemiológicos, 10 a revisiones documentales, dos estudios clínicos y una carta al editor. Brasil fue el país con más publicaciones (50%), la mayoría con enfoque epidemiológico. La temática más abordada fue la medición de prevalencia de la infección por hepatitis B con 22 publicaciones, le siguieron 11 estudios que informan resultados de estudios moleculares del virus, siete estudios sobre vacunación, cinco estudios sobre factores de riesgo y cuatro publicaciones con temas como la transmisión vertical y estudios sociales. Conclusión. En comparación con revisiones previas realizadas por otros autores, se observa una mayor diversidad en los temas y métodos de investigación utilizados; sin embargo, aún prevalecen los enfoques epidemiológicos convencionales centrados en la medición de la prevalencia de marcadores serológicos. Esto hace necesario encarar otro tipo de investigaciones centradas en los determinantes socioculturales.


[ABSTRACT]. Objective. Identify publications from 2000 to 2020 on hepatitis B in indigenous people in Latin America, to learn about advances and gaps in this field in the last 20 years. Methods. Exploratory review and systematic evidence review. Documents were organized using Excel and Rayyan® software. Results. We selected 30 of 107 articles found: 17 epidemiological studies, 10 document reviews, 2 clinical studies, and 1 letter to the editor. Brazil was the country with the most publications (50%), most of them with an epidemiological approach. The topic most often addressed was hepatitis B prevalence with 22 publications, followed by 11 studies reporting results of molecular studies of the virus, 7 studies on vaccination, 5 studies on risk factors, and 4 publications with topics such as vertical transmission and studies of social issues. Conclusion. Compared to previous reviews by other authors, we saw greater diversity in topics and research methods; however, conventional epidemiological approaches that focus on measuring prevalence of serological markers still predominate. Thus, there is a need for other types of research focused on sociocultural determinants.


[RESUMO]. Objetivo. Identificar artigos publicados entre 2000 e 2020 sobre hepatite B em indígenas da América Latina, visando a conhecer as conquistas obtidas nos últimos 20 anos e as lacunas existentes com relação a esta doença. Métodos. Foi realizada uma revisão exploratória da literatura com síntese das evidências. O material obtido foi organizado com o uso de Excel® e Rayyan®. Resultados. De 107 artigos encontrados, 30 foram selecionados – 17 estudos epidemiológicos, 10 revisões documentais, 2 estudos clínicos e 1 carta ao editor. O Brasil foi o país com o maior percentual de artigos publicados (50%), na sua maioria estudos com enfoque epidemiológico. As áreas temáticas abordadas foram a prevalência de infecção pelo vírus da hepatite B (22 artigos), estudos moleculares do vírus da hepatite (11 estudos), vacinação (7), fatores de risco (5), e temas como transmissão materno-fetal e aspectos sociais (4). Conclusões. Comparado aos estudos de revisão anteriores conduzidos por outros autores, o presente estudo demonstra uma maior variedade de áreas temáticas e metodologias empregadas. No entanto, ainda predominam enfoques epidemiológicos convencionais com foco na avaliação da prevalência de marcadores sorológicos. São necessárias outras linhas de pesquisas enfocando os determinantes socioculturais.


Assuntos
Hepatite , Grupos Populacionais , Saúde de Populações Indígenas , América Latina , Grupos Populacionais , Saúde de Populações Indígenas , América Latina , Hepatite , Grupos Populacionais , Saúde de Populações Indígenas
20.
Eur J Med Res ; 27(1): 45, 2022 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-35313994

RESUMO

BACKGROUND: Hepatitis-associated aplastic anemia (HAAA) is a specific type of aplastic anemia, and hematopoietic stem-cell transplantation (HSCT) is recommended as the first-line. Acute rhabdomyolysis (AR) during hematopoietic stem-cell transplantation (HSCT) is a rare, serious complication, with only 10 cases reported in the world so far. CASE PRESENTATION: Herein, we present a case of AR developing during HLA-haploidentical HSCT in a 55-year-old man who suffered from HAAA. On day 7 after stem cell transfusion, the patient reported a muscle pull in thigh and complained of muscle swelling, pain and change in urine color. Despite the timely diagnosis (based on the levels of myoglobin and creatine kinase, and muscle MRI findings, etc.) and rapid hydration and alkalization, the situation progressed dramatically, and the patient died of multi-organ failure during the preparation for continuous renal replacement therapy (CRRT). Five days after his death, the whole-exome sequencing result confirmed that the patient had a germline missense mutation in SCN4A I 1545 V and ACTN3 R577X. CONCLUSION: AR is a rare but threatening complication during HSCT, especially in cases with kidney dysfunction. The creatine kinase level may not truly and completely reflect the severity and prognosis for cases with localized lesion. We suggest that genetic analysis should be performed for better understanding the pathological changes of AR during HSCT, especially for patients with bone marrow failure.


Assuntos
Anemia Aplástica/complicações , Anemia Aplástica/fisiopatologia , Anemia Aplástica/terapia , Hepatite/complicações , Rabdomiólise/etiologia , Rabdomiólise/fisiopatologia , Rabdomiólise/terapia , Anemia Aplástica/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Transplante de Células-Tronco/métodos , Transplante Homólogo/métodos , Resultado do Tratamento
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