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1.
Molecules ; 26(6)2021 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-33807029

RESUMO

Natural products are gaining more interest recently, much of which focuses on those derived from medicinal plants. The common chicory (Cichorium intybus L.), of the Astraceae family, is a prime example of this trend. It has been proven to be a feasible source of biologically relevant elements (K, Fe, Ca), vitamins (A, B1, B2, C) as well as bioactive compounds (inulin, sesquiterpene lactones, coumarin derivatives, cichoric acid, phenolic acids), which exert potent pro-health effects on the human organism. It displays choleretic and digestion-promoting, as well as appetite-increasing, anti-inflammatory and antibacterial action, all owing to its varied phytochemical composition. Hence, chicory is used most often to treat gastrointestinal disorders. Chicory was among the plants with potential against SARS-CoV-2, too. To this and other ends, roots, herb, flowers and leaves are used. Apart from its phytochemical applications, chicory is also used in gastronomy as a coffee substitute, food or drink additive. The aim of this paper is to present, in the light of the recent literature, the chemical composition and properties of chicory.


Assuntos
Chicória/química , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Antibacterianos/química , Antibacterianos/farmacologia , Antifúngicos/química , Antifúngicos/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Antiparasitários/química , Antiparasitários/farmacologia , Antivirais/química , Antivirais/farmacologia , Chicória/fisiologia , Culinária , Hipersensibilidade Alimentar/etiologia , Humanos , Hipoglicemiantes/química , Hipoglicemiantes/farmacologia , Plantas Medicinais/química
2.
Rev Med Liege ; 76(2): 77-82, 2021 Feb.
Artigo em Francês | MEDLINE | ID: mdl-33543851

RESUMO

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. Its pathophysiology is still poorly understood. FPIES mainly affects infant and young children, although cases have been reported in adults. Its symptomatology is restricted to gastrointestinal manifestations and the onset of allergic reaction subsequent to exposure is delayed. The most common culprit for children is cow's milk. Initial clinical presentation of FPIES is oftentimes acute, though it can also be chronic. Diagnosis relies on clinical criteria, which have been recently redefined and subject to international consensus. Through two clinical cases, this report aims to describe the characteristics of this emerging disease as well as delineate the treatment thereof.


Assuntos
Enterocolite , Hipersensibilidade Alimentar , Adulto , Alérgenos , Animais , Bovinos , Criança , Pré-Escolar , Proteínas na Dieta , Enterocolite/diagnóstico , Enterocolite/etiologia , Feminino , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Alimentar/etiologia , Humanos , Lactente , Síndrome
3.
Methods Mol Biol ; 2223: 1-17, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33226583

RESUMO

Mouse models of allergic disease offer numerous advantages when compared to the models of other animals. However, selection of appropriate mouse models is critical to advance the field of food allergy by revealing mechanisms of allergy and for testing novel therapeutic approaches. All current mouse models for food allergy have weaknesses that may limit their applicability to human disease. Aspects such as the genetic predisposition to allergy or tolerance from the strain of mouse used, allergen dose, route of exposure (oral, intranasal, intraperitoneal, or epicutaneous), damage of the epithelial barrier, use of adjuvants, food matrix effects, or composition of the microbiota should be considered prior to the selection of a specific murine model and contemplated according to the intended purpose of the study. This chapter reviews our current knowledge on the application of mouse models to food allergy research and the variables that may influence the successful development of each type of model.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Alérgenos/administração & dosagem , Modelos Animais de Doenças , Hipersensibilidade Alimentar/imunologia , Regulação da Expressão Gênica/imunologia , Alérgenos/química , Animais , Toxinas Bacterianas/administração & dosagem , Misturas Complexas/administração & dosagem , Misturas Complexas/química , Vias de Administração de Medicamentos , Hipersensibilidade Alimentar/etiologia , Hipersensibilidade Alimentar/genética , Hipersensibilidade Alimentar/patologia , Fatores de Troca do Nucleotídeo Guanina/genética , Fatores de Troca do Nucleotídeo Guanina/imunologia , Humanos , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C3H , Camundongos Knockout , Receptores de Superfície Celular/genética , Receptores de Superfície Celular/imunologia , Especificidade da Espécie , Receptor 4 Toll-Like/genética , Receptor 4 Toll-Like/imunologia
4.
Ann Agric Environ Med ; 27(3): 413-417, 2020 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-32955224

RESUMO

INTRODUCTION: Allergy affects approximately one-third of the world's population, and the rates are growing. In Europe, it has been noticed that the risk of asthma and allergy is lower in the rural as opposed to urban population. There is a tendency for several allergic diseases to be present in the same person at the same time. OBJECTIVE: The aim of the study was to verify the co-occurrence of allergic multimorbidity and food allergy and intolerance in a group of children. MATERIAL AND METHODS: The multicentre cross-sectional study enrolled 1,008 children and adolescence aged 6-18 years (51.2% boys, 48.8% girls). The study comprised a questionnaire (respondents' declarations) and an outpatient examination (diagnostic examination followed by a medical diagnosis). The study was conducted as part of the 2016-2020 National Health Programme. RESULTS: In the study group, allergic rhinitis (AR) was present in 46.4%, bronchial asthma (BA) in 11.2% and atopic dermatitis (AD) in 6%. Allergic multimorbidity (simultaneous presence of 2 or more of the allergic diseases AR, BA and AD) was diagnosed in 9.7%. A single allergic disease (of the 3) was diagnosed in 43.4%. A diagnosis of food allergy and food intolerance was reported respectively at 29.6% and 14.3% participants with doctor-diagnosed allergic multimorbidity. Among those without any of the 3 allergic diseases, the percentage were 14.4% and 9.1%, respectively. CONCLUSIONS: Food allergy or food intolerance was more common in subjects with allergic multimorbidity than in subjects diagnosed with one allergic disease or those free of allergic diseases.


Assuntos
Hipersensibilidade Alimentar/epidemiologia , Intolerância Alimentar/epidemiologia , Multimorbidade , Adolescente , Criança , Estudos Transversais , Feminino , Hipersensibilidade Alimentar/etiologia , Intolerância Alimentar/etiologia , Humanos , Hipersensibilidade/epidemiologia , Hipersensibilidade/etiologia , Masculino , Polônia/epidemiologia , Prevalência
5.
Environ Health Prev Med ; 25(1): 27, 2020 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-32635895

RESUMO

BACKGROUND: Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity. We examined the relationship between immunisation with different vaccine types and later allergic disease development. METHODS: We obtained information regarding vaccinations and allergic diseases through questionnaires that were used in The Japan Environment and Children's Study (JECS), which is a nationwide, multicentre, prospective birth cohort study that included 103,099 pregnant women and their children. We examined potential associations between the initial vaccination before 6 months of age and symptoms related to allergies at 12 months of age. RESULTS: Our statistical analyses included 56,277 children. Physician-diagnosed asthma was associated with receiving three (aOR 1.395, 95% CI 1.028-1.893) or four to five different inactivated vaccines (aOR 1.544, 95% CI 1.149-2.075), compared with children who received only one inactivated vaccine. Similar results were found for two questionnaire-based symptoms, i.e. wheeze (aOR 1.238, 95% CI 1.094-1.401; three vaccines vs. a single vaccine) and eczema (aOR 1.144, 95% CI 1.007-1.299; four or five vaccines vs. a single vaccine). CONCLUSIONS: Our results, which should be cautiously interpreted, suggest that the prevalence of asthma, wheeze and eczema among children at 12 months of age might be related to the amount of inactivated vaccine exposure before 6 months of age. Future work should assess if this association is due to cumulative adjuvant exposure. Despite this possible association, we strongly support the global vaccination strategy and recommend that immunisations continue. TRIAL REGISTRATION: UMIN000030786 .


Assuntos
Hipersensibilidade/epidemiologia , Vacinas Virais/efeitos adversos , Asma/epidemiologia , Asma/etiologia , Estudos de Coortes , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Feminino , Hipersensibilidade Alimentar/epidemiologia , Hipersensibilidade Alimentar/etiologia , Humanos , Hipersensibilidade/etiologia , Lactente , Recém-Nascido , Japão , Masculino , Vacinas de Produtos Inativados/efeitos adversos
6.
South Med J ; 113(6): 267-274, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32483635

RESUMO

Red meat allergies have followed tick bites on every continent except Antarctica. The sensitizing antigen is galactose-α-1,3-galactose (α-gal), an oligosaccharide constituent of nonprimate blood and meat, acquired by ticks during animal bloodfeeding. Because red meat allergy after tick bites is a worldwide phenomenon, the objectives of this review were to describe the global epidemiology of red meat allergy after tick bites and its immunological mechanisms; to identify the human risk factors for red meat allergy after tick bites; to identify the most common tick vectors of red meat allergy worldwide; to describe the clinical manifestations, diagnostic confirmation, and management of patients with red meat allergy after tick bites; and to recommend strategies for the prevention of tick bites. To meet these objectives, Internet search engines were queried with keywords to select scientific articles for review. The keywords included ticks, tick bites, allergy, anaphylaxis, and meat allergy. The study period was defined as 1980-2019. The major risk factors for red meat allergy after tick bites included male sex, non-B blood type, systemic mastocytosis, a bioprosthetic (bovine or porcine) heart valve, and preexisting allergies to gelatin or animal dander. Following confirmation by challenge testing, patients with red meat allergies should avoid red meats, foods containing gelatin, and intravenous immunotherapy with monoclonal antibodies such as cetuximab and infliximab produced in SP2/0 mouse cell lines. Red meat allergy after tick bites represents an emerging threat from tick bites in addition to infectious diseases.


Assuntos
Hipersensibilidade Alimentar/epidemiologia , Picadas de Carrapatos/complicações , Sistema ABO de Grupos Sanguíneos , Animais , Bioprótese , Dissacarídeos/imunologia , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Alimentar/etiologia , Hipersensibilidade Alimentar/imunologia , Próteses Valvulares Cardíacas , Humanos , Ixodidae , Carne Vermelha , Fatores de Risco , Picadas de Carrapatos/prevenção & controle
7.
J Dairy Sci ; 103(8): 6771-6781, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32505409

RESUMO

Hypoallergenic formulas are recommended for infants who are not breastfed and cannot tolerate cow milk formulas due to allergy. These formulas are hydrolyzed to break down larger protein chains into shorter, easy-to-digest, and potentially less allergenic proteins. Hydrolysis, however, possibly occurs at the expense of the transforming growth factor beta (TGF-ß) and anti-inflammatory activity that is inherent in regular formula. Our objective was to determine the TGF-ß and the anti-inflammatory activity of commercially available hypoallergenic and regular formulas. Human gingival fibroblasts were incubated with reconstituted formulas followed by detection of TGF-ß target genes and activation of Smad2/3 signaling. Gingival fibroblasts and the oral squamous cell carcinoma cell line HSC-2 were also exposed to formulas before adding interleukin (IL)1ß and tumor necrosis factor (TNF)α to provoke expression of pro-inflammatory cytokines. For murine bone marrow-derived macrophages, pro-inflammatory cytokine expression was stimulated with saliva. Changes in p65 nuclear translocation and phosphorylation of smad3 and p38 were analyzed by immunostaining. Our study demonstrated that regular formula, but not hypoallergenic formula, enhanced the expression of TGF-ß target genes IL11, PRG4, and NOX4 in gingival fibroblasts. Hypoallergenic formulas also failed to initiate nuclear translocation of Smad2/3 and phosphorylation of Smad3. Moreover, regular formulas were more potent than hypoallergenic formulas in reducing the expression of pro-inflammatory cytokines in gingival fibroblasts, HSC-2 epithelial cells, and murine bone marrow macrophages. Hypoallergenic and regular formulas had a similar capacity to reduce p65 nuclear translocation and phosphorylation of p38 in fibroblasts. These findings suggest that hypoallergenic formulas lack in vitro TGF-ß activity and have a lower anti-inflammatory activity compared with regular formulas.


Assuntos
Hipersensibilidade Alimentar/etiologia , Fórmulas Infantis , Fator de Crescimento Transformador beta/metabolismo , Animais , Anti-Inflamatórios/química , Anti-Inflamatórios/metabolismo , Bovinos , Linhagem Celular Tumoral , Citocinas/metabolismo , Fibroblastos/metabolismo , Humanos , Lactente , Fórmulas Infantis/efeitos adversos , Fórmulas Infantis/química , Camundongos , Leite/imunologia , Leite/metabolismo , Transdução de Sinais , Proteína Smad2/metabolismo , Proteína Smad3/metabolismo
8.
Arerugi ; 69(3): 209-212, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32435022

RESUMO

A 28-year-old man was transferred to our emergency room for dyspnea and wheals on the entire body. He had eaten landlocked ayu fish (Plecoglossus altivelis) the so-called "koayu fish", from Lake Biwa, and had immediately experienced a stomachache. Wheals and dyspnea developed one hour later and were successfully treated with intravenous corticosteroids. The patient was examined for koayu fish and related allergens by skin prick and allergen-specific immunoglobulin E (IgE) (ImmunoCAP®) tests. Positive skin prick results were obtained for Lake Biwa koayu fish (raw and heated) as well as for standard skin test allergens (prepared by Torii pharmaceuticals) including shrimp, crab, and squid. Negative prick test results were observed for regular ayu fish and other fish such as horse mackerel, sardine, salmon, mackerel, codfish, and tuna. Allergen-specific IgE tests (ImmunoCAP ®) showed positivity for shrimp, crab, ticks, moths, and mosquitoes, while ImmunoCAP® tests were negative for the allergen components rGad c 1 (pollackparvalbumin) and rPen a 1 (shrimp tropomyosin). Moreover, enzyme-linked immunosorbent assay (ELISA) tests were negative for mackerel parvalbumin and collagen. We considered this case to be of anaphylaxis caused by koayu fish from Lake Biwa and speculated that a novel koayu-specific antigen might have been the cause of the condition.


Assuntos
Anafilaxia/etiologia , Hipersensibilidade Alimentar/etiologia , Osmeriformes , Adulto , Animais , Humanos , Japão , Lagos , Masculino , Testes Cutâneos
10.
Int Arch Allergy Immunol ; 181(5): 365-374, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32097952

RESUMO

OBJECTIVE: Precise diagnosis of allergy requires knowledge of the population's food allergy (FA) spectrum and predictors. METHODS: Medical charts of Turkish children aged 0-2 years with FA and/or atopic dermatitis (AD) were reviewed. RESULTS: A total of 1,389 patients, 912 with FA and 1,140 with AD, were included. In the FA group, the most frequently diagnosed FAs were egg white (75.9%), cow's milk (55.7%), tree nuts (31.5%) and sesame (20.6%). The detection of FA in 99% of children with any kind of FA necessitate testing with egg white, cow's milk, hazelnut, sesame, walnut, cashew, and pistachio. In the FA group, 72.7 and 56.8% had AD and multiple FA respectively. Multiple FA (56.8 vs. 49.8%) and hen's egg allergy (85.5 vs. 50.2%, p < 0.005) were more common and cow's milk allergy (51.4 vs. 67.1%, p < 0.005) less common in the AD subgroup of the FA group than in the non-AD subgroup. Multiple FA likelihood increases parallel to the severity of AD (p < 0.05). In the AD group, 58.2% had an immunoglobulin E-mediated FA. The risk of concomitant FA increased as the age at symptom onset of AD decreased (OR 0.800 [95% CI 0.731-0.875]; p < 0.001) and the severity of AD increased (OR 2.350 [95% CI 1.898-2.911]; p < 0.001). CONCLUSION: Although severe and early-onset AD is a predictor of the presence and magnitude of FA in infancy, the spectrum of FA is a reflection of cultural characteristics. The clinical presentations of both AD and FA may in fact be an expression of the extent of the immune dysregulation underlying atopy and allergy.


Assuntos
Hipersensibilidade Alimentar/epidemiologia , Hipersensibilidade Alimentar/etiologia , Pré-Escolar , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Dermatite Atópica/imunologia , Feminino , Hipersensibilidade Alimentar/imunologia , Humanos , Imunoglobulina E , Lactente , Recém-Nascido , Masculino , Prevalência , Estudos Retrospectivos , Turquia/epidemiologia
11.
Korean J Gastroenterol ; 75(1): 11-16, 2020 01 25.
Artigo em Coreano | MEDLINE | ID: mdl-31986568

RESUMO

Non-celiac gluten sensitivity (NCGS) is a term that is used to describe individuals who are not affected by celiac disease or wheat allergy, yet they have intestinal and/or extra-intestinal symptoms related to gluten ingestion with improvement of their symptoms upon withdrawing gluten from their diet. Gluten-related disorder groups are manifested by symptoms of gastrointestinal tract disorders, as well as hematological dermatological endocrinological, gynecological, rheumatological and nervous system symptoms. It is believed that NCGS represents heterogeneous groups with different subgroups characterized by different etiologies, clinical histories and clinical courses. There also appears to be an overlap between NCGS and irritable bowel syndrome (IBS). There is a need for establishing strict criteria for diagnosing NCGS. The absence of validated biomarkers remains a significant limitation for research studies on NCGS. New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS. Further studies about NCGS are needed.


Assuntos
Gastroenteropatias/diagnóstico , Glutens/efeitos adversos , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/etiologia , Dieta Livre de Glúten , Hipersensibilidade Alimentar/diagnóstico , Hipersensibilidade Alimentar/etiologia , Gastroenteropatias/etiologia , Glutens/administração & dosagem , Síndrome do Intestino Irritável/diagnóstico , Síndrome do Intestino Irritável/etiologia
13.
Allergol Int ; 69(1): 11-18, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31784246

RESUMO

Gibberellin-regulated proteins (GRPs)/GASA proteins are members of cysteine-rich antimicrobial peptide families and are conserved in a broad range of plants. Some GRPs in fruits and pollens have been identified as allergens including peach Pru p 7, Japanese apricot Pru m 7, orange Cit s 7, pomegranate Pun g 7, and cypress pollen GRP. The clinical features of fruit-derived GRP allergies frequently include systemic reactions, multiple fruit allergies regardless of plant kingdom classifications and, less frequently, cofactor-dependence. Multiple fruit allergies might be related to cross-reactivity between GRPs. Clinical cross-reactivity, at least between the four fruit-derived GRPs, has been proven. In addition, GRP allergy induces peculiar clinical symptoms, such as laryngeal tightness and facial swelling, especially eyelid edema, which was proposed to be a predictive factor for Pru p 7 allergy. Fruit-derived GRPs have an unusually high content of cysteine, resulting in high stability to heat and resistance to digestive enzymes. Therefore, GRPs are considered "true" food allergens that induce severe allergic reactions. As an alternative mechanism of fruit-derived GRP allergies, cross-reactivity between fruit GRP and cypress pollen GRP, which might play a role as a sensitizer, is suspected. Taken together, these characteristics indicate GRPs are clinically relevant plant allergens. This review article summarizes our current knowledge of the clinical features and important aspects of GRP sensitization and allergy.


Assuntos
Alérgenos/imunologia , Antígenos de Plantas/imunologia , Hipersensibilidade Alimentar/etiologia , Giberelinas/imunologia , Alérgenos/efeitos adversos , Antígenos de Plantas/efeitos adversos , Reações Cruzadas , Hipersensibilidade Alimentar/imunologia , Giberelinas/efeitos adversos , Humanos , Proteínas de Plantas/efeitos adversos , Proteínas de Plantas/imunologia
14.
Am J Emerg Med ; 38(2): 412.e1-412.e2, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31864870

RESUMO

Shiitake dermatitis is a rare adverse cutaneous reaction to the ingestion of raw or undercooked shiitake mushrooms (Lentinula edodes). We report the case of a patient who developed a striking linear flagellate dermatitis without urticaria three days after returning from a trip from Tokyo where he had eaten shiitake mushrooms. The rash resolved after two weeks with topical corticosteroids and antihistamines given for symptomatic relief. Shiitake dermatitis is thought to be either a toxic or hypersensitivity reaction to lentinan, a heat-inactivated polysaccharide found in the cell walls of shiitake mushrooms. Although this mushroom is widely consumed in Eastern Asia, with the increasing globalisation of cuisine and travel, cases are likely to become more common in the Western world.


Assuntos
Dermatite/etiologia , Hipersensibilidade Alimentar/etiologia , Lentinano/efeitos adversos , Cogumelos Shiitake/química , Administração Tópica , Corticosteroides/administração & dosagem , Dermatite/tratamento farmacológico , Antagonistas dos Receptores Histamínicos/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Pele/patologia , Viagem
15.
Asian Pac J Allergy Immunol ; 38(1): 40-46, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30447652

RESUMO

BACKGROUND: Entomophagy is a common practice in many parts of the world. Allergic symptoms after insect consumption have been reported in healthcare literature and in the news. OBJECTIVE: We evaluated prevalence and association of allergic history and self-reported allergic reactions after entomophagy. METHODS: We conducted a cross sectional internet-based survey. Participants were people who have consumed insects. Collected information included demographic data, the practice of entomophagy, allergic history and self-reported allergic symptoms. RESULTS: During May to October 2017, 140 people completed the survey. Median and range of age are 27 and 18-64 years. Ninety-two (65.7%) were female. Thirty-seven (26.4%) and 13 (9.3%) participants had history of allergy and seafood allergy, respectively. Eighteen (12.9%; 95% confidence intervals (CI) 7.3-18.4) participants reported allergic reactions after insect consumption. Nine symptomatic participants reported other people who partook insects to have allergic symptoms. Reported factors with significant association with allergic reactions were history of allergy and seafood allergy with prevalence ratios of 4.83 (CI 1.83-10.44) and 3.76 (CI 1.59-8.87), respectively. CONCLUSIONS: The prevalence of self-reported allergic reactions after entomophagy is 12.9%. Clusters of people with post-entomophagy allergic symptoms are found. History of allergy and seafood allergy are associated with post-entomophagy allergic reactions.


Assuntos
Insetos Comestíveis/imunologia , Hipersensibilidade Alimentar/epidemiologia , Adolescente , Adulto , Animais , Estudos Transversais , Feminino , Hipersensibilidade Alimentar/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Alimentos Marinhos/efeitos adversos , Autorrelato , Inquéritos e Questionários , Tailândia , Adulto Jovem
16.
Arch Environ Occup Health ; 75(1): 18-26, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30595111

RESUMO

The association between early daycare attendance and risk of allergic diseases remains inconclusive. Therefore, we examined the association among Japanese children on a long-term basis using a nationwide longitudinal survey data. We estimated the association between daycare attendance at age 6 or 18 months and allergy development using information on outpatient visits for atopic dermatitis (AD), food allergy (FA), and asthma and admission for asthma up to 12 years of age as a proxy for developing these diseases, with multilevel logistic regression. Early daycare attendance was associated with increased odds of AD at ages 2.5-3.5 years: the adjusted odds ratio (OR) was 1.34 [95% CI: 1.21, 1.47]. The association with FA was equivocal. The odds of asthma was increased before age 3.5 years and afterwards decreased: the adjusted ORs were 1.60 [1.44, 1.77] for ages 1.5-2.5 years and 0.77 [0.69, 0.87] for ages 5.5-7 years. The effect of early daycare attendance depends on the type of allergies.


Assuntos
Asma/epidemiologia , Creches/estatística & dados numéricos , Dermatite Atópica/epidemiologia , Hipersensibilidade Alimentar/epidemiologia , Hospitalização/estatística & dados numéricos , Saúde do Lactente/estatística & dados numéricos , Asma/etiologia , Dermatite Atópica/etiologia , Hipersensibilidade Alimentar/etiologia , Humanos , Hipersensibilidade , Incidência , Lactente , Japão/epidemiologia , Estudos Longitudinais
17.
Food Chem ; 302: 125333, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31416005

RESUMO

This study was performed to determine Parvalbumin (PV), a well-known fish allergenic protein, digestion kinetics and immunoreactivity of digestion products with Immunoglobulin G/Immunoglobulin E recognition to understand its allergic potential with or without lipid emulsion process. PV was subjected to simulated gastrointestinal digestion in emulsified condition. Digestion kinetics of the protein was analysed by electrophoresis, IgG/IgE binding ability by immunoblotting and indirect ELISA. Lipid emulsion significantly (p < 0.01) reduced the degree of PV hydrolysis by 52.10% for gastric digestion. Immune fragments of gastric digestion were detectable for 90-120 min longer in emulsified condition showing resistance. Consequently, lipid emulsion decreased the digestive ability of PV in stomach, increasing resistance to gastrointestinal digestion by pepsin proteases. It also altered IgG/IgE binding ability of digestion products, thereby indicating that PV with lipid emulsion was resistant to digestion and possessed increased IgE binding ability resulting in higher risk of allergy among sensitized individuals.


Assuntos
Alérgenos/farmacocinética , Emulsões/farmacocinética , Proteínas de Peixes da Dieta/farmacocinética , Hipersensibilidade Alimentar/imunologia , Parvalbuminas/farmacocinética , Alérgenos/imunologia , Alérgenos/metabolismo , Animais , Digestão , Emulsões/química , Ensaio de Imunoadsorção Enzimática , Feminino , Proteínas de Peixes da Dieta/imunologia , Linguados , Hipersensibilidade Alimentar/etiologia , Immunoblotting , Imunoglobulina E/imunologia , Imunoglobulina E/metabolismo , Imunoglobulina G/imunologia , Imunoglobulina G/metabolismo , Lipídeos/química , Lipídeos/farmacocinética , Camundongos Endogâmicos BALB C , Parvalbuminas/imunologia , Parvalbuminas/metabolismo , Pepsina A/metabolismo
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