Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 5.169
Filtrar
1.
Yonsei Med J ; 61(9): 797-804, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32882764

RESUMO

PURPOSE: Climate and lifestyle changes increase an individual's susceptibility to various allergens and also the incidence of allergic diseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiary hospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E (IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and tree pollen mixtures, as well as cat and dog dander through ImmunoCAP test. RESULTS: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for tree pollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p for trend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens (≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization to D. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). CONCLUSION: Children's sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased during the 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.


Assuntos
Alérgenos/imunologia , Asma/imunologia , Hipersensibilidade/diagnóstico , Imunoglobulina E/sangue , Rinite Alérgica/imunologia , Alérgenos/efeitos adversos , Animais , Asma/diagnóstico , Asma/epidemiologia , Gatos , Criança , Dermatophagoides farinae , Cães , Feminino , Humanos , Hipersensibilidade/imunologia , Masculino , Pólen/imunologia , República da Coreia/epidemiologia , Estudos Retrospectivos , Rinite Alérgica/diagnóstico
2.
Actas Dermosifiliogr ; 111(8): 650-654, 2020 Oct.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-32622869

RESUMO

As the COVID-19 pandemic gradually comes under control, the members of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) have drawn up a proposed list of the requirements, limitations, and conditioning factors affecting the resumption of work in contact dermatitis units. The assumption is that the severe acute respiratory syndrome coronavirus2 is still circulating and that occasional or seasonal outbreaks will occur. They recommend that the first step should be to assess how many patch tests each clinic can handle and review the waiting list to prioritize cases according to disease severity and urgency. Digital technologies can, where possible, be used to send and receive the documentation necessary for the patch test (information, instructions, informed consent, etc.). If the necessary infrastructure is available, patients can be offered the option of a remote initial consultation. Likewise, in selected cases, the patch test results can be read in a virtual visit using photographs taken by the patient or a video visit can be scheduled to allow the physician to evaluate the site of application remotely. These measures will reduce the number of face-to-face visits required, but will not affect the time spent on each case, which must be scheduled in the normal manner. All of these recommendations are suggestions and should be adapted to the needs and possibilities of each health centre.


Assuntos
Betacoronavirus , Infecções por Coronavirus/epidemiologia , Dermatologia/organização & administração , Testes do Emplastro/normas , Pneumonia Viral/epidemiologia , Telemedicina/organização & administração , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/prevenção & controle , Dermatite Alérgica de Contato/diagnóstico , Inquéritos Epidemiológicos/normas , Humanos , Hipersensibilidade/diagnóstico , Visita a Consultório Médico , Pandemias/prevenção & controle , Acesso dos Pacientes aos Registros , Pneumonia Viral/diagnóstico , Pneumonia Viral/prevenção & controle , Gestão de Riscos/organização & administração , Espanha/epidemiologia , Avaliação de Sintomas/métodos , Telepatologia , Triagem/organização & administração , Listas de Espera
3.
Allergol. immunopatol ; 48(3): 244-250, mayo-jun. 2020. graf, tab
Artigo em Inglês | IBECS | ID: ibc-192026

RESUMO

INTRODUCTION AND OBJECTIVES: Eosinophilic esophagitis (EoE) is frequently miss-diagnosed or overlooked for several years because of the invasiveness of investigations and the non-specificity of symptoms in childhood. Due to the lack of specific recommendations in children, its management remains very heterogeneous, especially concerning allergy testing. The aim of this study is to analyze our population and practices, in comparison with the literature, with a focus on allergic management, to harmonize and optimize our practice. MATERIAL AND METHODS: We included all children with a diagnosis of EoE at the Hospital Femme Mere Enfant, Bron, France. Data were collected via retrospective chart review. RESULTS: 108 patients were included with an average age of 9.5 years. Average delay before diagnosis was 6.65 years. Symptoms varied with age, with a predominance of vomiting (60% of patients), feeding difficulties (72%) and growth difficulties (24%) in children < 5 years, whereas older children often presented with feeding blockage (64%) and dysphagia (61%). Cough was frequent in our cohort (18.5%), especially in children < 10 years (38.5% between three and five years). The allergic background was frequent (70.3%) and 80% of our patients benefited from allergy testing. Allergy testing was particularly useful to guide therapy as elimination diet represented an effective treatment in 60% of our patients CONCLUSIONS: Allergy testing has to be harmonized to include major allergens (egg, milk, peanut, fish, wheat, and soy), including prick and patch tests. Allergy-testing based diet seemed to be the best compromise between efficiency and constraints, especially in mono-sensitized patients


No disponible


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Esofagite Eosinofílica/imunologia , Esofagite Eosinofílica/diagnóstico , Técnicas Imunológicas , Estudos Retrospectivos , Hipersensibilidade/diagnóstico , Esofagite Eosinofílica/complicações , Hipersensibilidade Alimentar/diagnóstico , Rinite Alérgica/diagnóstico , Dermatite Atópica/diagnóstico , Endoscopia , Imunoglobulina E/análise , Testes Cutâneos
4.
Allergol. immunopatol ; 48(3): 259-264, mayo-jun. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-192028

RESUMO

The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens prevalent in the studied population, may serve as screening tests and facilitate the diagnosis of allergic disease or its exclusion. We assessed the positivity of two versions of these tests, Phadiatop Europe® (PhEU) and Phadiatop Infant® (PhInf), as well as total IgE (TigE) values in patients with a medical diagnosis of allergic disease and non-allergic individuals. METHODS: A cross-sectional study performed in eleven Brazilian pediatric allergy centers with patients divided into groups according to the primary condition and a group of assessed control subjects. They were submitted to TIgE measurement and screening tests (PhEu and PhInf). RESULTS: TIgE mean serum levels were significantly higher among allergic patients, especially those with asthma/rhinitis or atopic dermatitis. The positivity of the screening tests, considering the total population, was 63.8% for PhEU and 72.6% for PhInf. These increased when we evaluated only the allergic subjects. The concordance index of the two tests was Kappa = 0.7 and higher among those of greater age. CONCLUSIONS: In the assessed population, there were significantly higher levels among those with positive screening tests and PhInf showed better performance in the identification of sensitized individuals, regardless of age. This is the first study to evaluate Phadiatop and Phadiatop Infant in the same population


No disponible


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Testes Hematológicos/métodos , Hipersensibilidade/diagnóstico , Imunoglobulina E/sangue , Técnicas Imunológicas/métodos , Hipersensibilidade/imunologia , Brasil , Estudos Transversais , Alérgenos/imunologia , Dermatite Atópica/imunologia , Asma/imunologia , Rinite Alérgica/imunologia , Sensibilidade e Especificidade
6.
Rev Med Suisse ; 16(689): 688-693, 2020 Apr 08.
Artigo em Francês | MEDLINE | ID: mdl-32270936

RESUMO

Allergy to furry animals is a frequent health issue, and should be suspected when investigating any yearlong rhinoconjonctivitis or asthma. A detailed medical history and skin prick tests are usually sufficient for diagnosis, and if necessary, specific IgE testing may be performed. In case of proven hypersensitivity, avoidance of animal allergens is the main therapeutic measure, primarily by removing the animal from the patient's environment, in association with symptomatic treatment. If animal removing is impossible, other measures exist to decrease allergen load, but not with the same -efficacy as removing the animal, particularly for asthma. Immunotherapy is available for cat and dog allergy, but indication is to be carefully discussed.


Assuntos
Asma , Cabelo/imunologia , Hipersensibilidade , Alérgenos/imunologia , Animais , Asma/diagnóstico , Asma/imunologia , Asma/terapia , Gatos , Cães , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/imunologia , Hipersensibilidade/terapia , Imunoterapia , Testes Cutâneos
7.
Allergol. immunopatol ; 48(2): 130-136, mar.-abr. 2020. tab
Artigo em Inglês | IBECS | ID: ibc-191815

RESUMO

BACKGROUND: Several studies suggest that early-life exposure to animal allergens constitutes a relevant risk factor for the development of allergic sensitization. OBJECTIVES: The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma. METHODS: The study included 51 children aged 5-18 years, both sexes, allergic to cats. Sensitization to cat allergen was confirmed by skin prick tests or specific IgE. Children were evaluated for the presence of bronchial asthma, atopic dermatitis, allergic rhinitis. A questionnaire evaluating the occurrence of allergic symptoms in children after contact with the cat and dog was performed. Mothers completed a questionnaire regarding cat exposure: during pregnancy and having a cat at home. A blood sample was taken from all children to measure the level of IL-33 in the serum. RESULTS: Keeping a cat in the home, once in the past, or having a cat in the home during the mother's pregnancy, revealed a statistically significant relationship with IL-33 levels in the studied patients. Also, daily contact with a cat during pregnancy affected the level of IL-33. Higher levels of IL-33 were shown in people with hypersensitivity to cat and pollen allergens and cat and other animals. In patients with bronchial asthma higher levels of IL-33 were found than in patients without bronchial asthma. CONCLUSIONS: Increased serum levels of IL-33 is related with keeping cats during pregnancy and in early childhood and can be associated with the development of asthma in children


No disponible


Assuntos
Humanos , Animais , Masculino , Feminino , Criança , Adolescente , Gatos , Interleucina-33/imunologia , Alérgenos/imunologia , Hipersensibilidade/diagnóstico , Gatos/imunologia , Hipersensibilidade/imunologia , Animais de Estimação/imunologia , Rinite/imunologia , Rinite/diagnóstico , Asma/diagnóstico , Asma/imunologia , Inquéritos e Questionários , Modelos Lineares
9.
Allergy Asthma Proc ; 41(2): 76-81, 2020 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-32122443

RESUMO

Telemedicine (TM) involves the use of technology to overcome the patient care barriers of distance and time. Asynchronous TM can be used to monitor patients remotely and for providers and patients to communicate with each other without needing to be online at the same time. Synchronous TM can include direct-to-consumer visits in which patients use their own equipment to communicate with a provider or facilitated visits in which a patient travels to a clinic to use the clinic's equipment with a facilitator. The advantage of the latter is that a physical examination can be performed. Although some patients and providers may prefer in-person visits, patients who are seen by TM report satisfaction that it is as good as or better than that of an in-person visit. TM can be used in the outpatient setting, in the hospital to perform consults, or in the school. The convenience of TM makes it likely that more patients will adopt TM as their preferred mode of obtaining health care. It is important for allergists to become familiar with this new technology because patients will demand it.


Assuntos
Hipersensibilidade/diagnóstico , Consulta Remota/métodos , Telemedicina/métodos , Alergistas , Alergia e Imunologia , Humanos , Monitorização Fisiológica , Satisfação do Paciente
10.
Ann Otol Rhinol Laryngol ; 129(7): 699-706, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32059621

RESUMO

BACKGROUND: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the sinonasal mucosa and with strong associations to other immune-mediated comorbidities. Patients often require referral to both an otolaryngologist and an allergist/immunologist. This study is the first in the literature to describe a multidisciplinary clinic that offers patient care by subspecialists in rhinology and in allergy/immunology. METHODS: One hundred twenty-nine patients were seen in the Comprehensive Sinus and Allergy Clinic (CSAC) between January 2016 and June 2017 and 43 selected patients were seen in both the standalone allergy and rhinology clinics over the same time period. Patient satisfaction was retrospectively assessed using a modified Press-Ganey satisfaction survey. Time to evaluation and time to follow up appointment were compared between the CSAC and both the standalone rhinology and allergy/immunology clinics. RESULTS: Patients seen in the CSAC reported high satisfaction with the amount of time spent with the physicians (98.3%), quality of medical care (9.3 ± 1.0), and most importantly, the convenience of seeing two physicians in one day (9.5 ± 1.2). Time from referral placement to clinic evaluation (P ≤ .02) and time to follow up appointment (P ≤ .002) was significantly shorter for the CSAC than for the standalone Rhinology or Allergy clinics. CONCLUSION: Patients reported high satisfaction with the medical care provided and were also seen much faster in our multidisciplinary clinic as compared to standalone rhinology or allergy/immunology clinics. Overall, a multidisciplinary approach may be beneficial to patients presenting to tertiary referral centers with CRS and atopic conditions.


Assuntos
Alergia e Imunologia/organização & administração , Assistência Ambulatorial/organização & administração , Hipersensibilidade/diagnóstico , Otolaringologia/organização & administração , Otorrinolaringopatias/diagnóstico , Satisfação do Paciente , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Instituições de Assistência Ambulatorial , Asma Induzida por Aspirina/diagnóstico , Asma Induzida por Aspirina/terapia , Doença Crônica , Dessensibilização Imunológica , Eficiência Organizacional , Feminino , Humanos , Hipersensibilidade/terapia , Imunoterapia , Masculino , Pessoa de Meia-Idade , Pólipos Nasais/diagnóstico , Pólipos Nasais/terapia , Procedimentos Cirúrgicos Nasais , Otorrinolaringopatias/terapia , Seios Paranasais/cirurgia , Equipe de Assistência ao Paciente , Qualidade da Assistência à Saúde , Encaminhamento e Consulta , Rinite/diagnóstico , Rinite/terapia , Rinite Alérgica/diagnóstico , Rinite Alérgica/terapia , Sinusite/diagnóstico , Sinusite/terapia , Adulto Jovem
11.
Allergol. immunopatol ; 48(1): 84-89, ene.-feb. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-186597

RESUMO

Background and objectives: Vitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood. Methods: Data were collected from 2642 children who visited the Guangdong Women and Children's Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age. Results: The mean level of serum 25(OH)D was 86.47 ± 27.55 nmol/L, with a high prevalence of vitamin D insufficiency (< 75 nmol/L) in children aged 0-2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200IU/mL (81.54 ± 25.53 nmol/L) compared with less than 100 IU/mL (87.92 ± 28.05 nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs. Conclusions: Serum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens


No disponible


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Vitamina D/análogos & derivados , Imunização/métodos , Imunoglobulina E/sangue , Hipersensibilidade/diagnóstico , Técnicas Imunoenzimáticas , Imunoglobulina E/imunologia , China
13.
Rev Mal Respir ; 37(3): 243-256, 2020 Mar.
Artigo em Francês | MEDLINE | ID: mdl-32057505

RESUMO

Allergy is a hypersensitivity reaction induced by immunological mechanisms. In asthma, allergy has a complex role and is usually IgE mediated. Allergy must be evaluated during the work up but evidence of IgE sensitivity does not mean that allergens play a role in the pathophysiology of the disease. The clinical relevance of the sensitivity has to be considered. This paper describes current available tools to screen for IgE sensitivity, allergen exposure and their role in asthma.


Assuntos
Asma/complicações , Asma/diagnóstico , Hipersensibilidade/complicações , Alérgenos/imunologia , Asma/imunologia , Testes de Provocação Brônquica , Humanos , Hipersensibilidade/diagnóstico , Imunoglobulina E/sangue , Testes Cutâneos
14.
J Thorac Cardiovasc Surg ; 160(2): 502-509.e1, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31959452

RESUMO

OBJECTIVES: Systemic allergic reactions to nickel alloys in percutaneous atrial septal defect occlusion devices have a poorly defined natural history. We describe our experience of surgical removal of the offending device in a series of patients with nickel allergy and refractory symptoms. METHODS: Patients with atrial septal defect device explants for nickel allergy were reviewed. Administered questionnaires focused on symptoms, quality of life, and satisfaction along with the 36-Item Short Form Health Survey to measure physical and mental health postsurgery. RESULTS: Atrial septal defect devices were removed for nickel allergy in 58 patients during the past 10 years. The median age was 42 years (range, 24-71 years) and 95% were women. Explantation occurred at a median of 8 years (range, 6 months-18 years) after insertion. Symptoms included fatigue (82%), chest pain (78%), headache (73%), and palpitation (58%). Surveys were available for 45 patients: 58% rated their quality of life as poor and 69% were not at all satisfied with their device. Postexplant, all patients reported improvement in their symptoms, with 18 patients (42%) noting complete resolution. In 12 patients prospectively studied, the preoperative scores in physical and mental health domains were lower than the validation group, indicating significant disability. Similarly, there was marked improvement in each domain postremoval. CONCLUSIONS: Patients with nickel allergy and severe refractory symptoms after atrial septal defect device implantation experience profound resolution of symptoms and improved quality of life after removal. Nickel allergy should be considered before device insertion, and a low threshold should exist for surgical removal for refractory symptoms.


Assuntos
Cateterismo Cardíaco/efeitos adversos , Cateterismo Cardíaco/instrumentação , Remoção de Dispositivo , Comunicação Interatrial/terapia , Hipersensibilidade/cirurgia , Níquel/efeitos adversos , Dispositivo para Oclusão Septal/efeitos adversos , Adulto , Idoso , Bases de Dados Factuais , Remoção de Dispositivo/efeitos adversos , Feminino , Nível de Saúde , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/etiologia , Masculino , Saúde Mental , Pessoa de Meia-Idade , Satisfação do Paciente , Desenho de Prótese , Qualidade de Vida , Estudos Retrospectivos , Índice de Gravidade de Doença , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
15.
Ann Allergy Asthma Immunol ; 124(3): 283-287, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31765814

RESUMO

BACKGROUND: Previous studies have suggested that exposures to indoor air-polluting factors during pregnancy and early life can influence childhood allergy development. These exposures have been investigated in singularity; however, the effect of simultaneous exposure to multiple factors remains unclear. OBJECTIVE: To evaluate the effect of prenatal and early-life exposure to 7 air-polluting factors on allergic sensitization at 2 years of age. METHODS: Mother-child pairs (n = 108) enrolled in the Kingston Allergy Birth Cohort were followed up from birth to 2 years of age. Exposure to air fresheners, candles, mold, cats, dogs, carpet, and environmental tobacco smoke (ETS) during the prenatal, 6-month, 1-year, and 2-year time points were obtained. A skin prick test (SPT) was performed on both the mother and the 2-year-old child. RESULTS: Exposure to candles during the prenatal window, cats during the 6-month window, and ETS at 2 years significantly increased the odds ratio (OR) of a positive SPT result (candles: OR, 5.096; 95% CI, 1.69-13.86; P = .006; cat: OR, 4.267; 95% CI, 1.096-15.68; P = .048; and ETS: OR, 3.78; 95% CI, 1.189-11.18; P = .04). Children with a positive SPT result had significantly more exposures than SPT-negative children (prenatal P = .005, 1-year P = .03, and 2-year P = .008). As the total number of exposures increased, the percentage of SPT-positive children increased (prenatal P = .005, 1-year P = .03, and 2-year P = .01). CONCLUSION: We have provided evidence supporting the role of the indoor environment on atopic disease development. The combined effect of multiple exposures may be more influential to allergy development than a single exposure.


Assuntos
Poluentes Atmosféricos/imunologia , Poluição do Ar em Ambientes Fechados/efeitos adversos , Alérgenos/imunologia , Hipersensibilidade/epidemiologia , Hipersensibilidade/imunologia , Exposição Materna/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal , Animais , Pré-Escolar , Estudos de Coortes , Exposição Ambiental/efeitos adversos , Feminino , Humanos , Hipersensibilidade/diagnóstico , Imunização , Lactente , Recém-Nascido , Masculino , Razão de Chances , Gravidez
19.
Blood Cells Mol Dis ; 80: 102370, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31669933

RESUMO

INTRODUCTION: Hemophilia is a rare bleeding disorder caused by a deficiency of the plasma coagulation factors VIII and IX (hemophilia A [HA] and hemophilia B [HB], respectively). Replacement therapy with clotting factor concentrates is the mainstay of treatment. Unlike in patients with HB, anaphylaxis in patients with HA is extremely rare. METHODS: A retrospective study of prospectively collected data on patients with hemophilia who experienced anaphylaxis was conducted in our center. Demographic and clinical data were collected, and laboratory workups that included thrombin generation were conducted. RESULTS: Our first patient underwent successful immune tolerance induction (ITI) following the administration of rituximab. The second patient was transitioned to emicizumab. The third patient receives recombinant activated VIIa (rFVIIa) on demand. Thrombin generation was performed following current medical management protocols for supporting hemostasis. DISCUSSION: Our case series illustrates the difficulty in managing patients with anaphylaxis to replacement therapy. In the era of novel therapies, such as emicizumab, the management of HA patients who experience anaphylaxis to replacement therapy is becoming easier and may obviate the need for ITI. Current treatment strategies for HB patients with such anaphylaxis, however, are limited to rFVIIa, and it continues to pose a challenge.


Assuntos
Hemofilia A/complicações , Hemofilia A/imunologia , Hemofilia B/complicações , Hemofilia B/imunologia , Hipersensibilidade/etiologia , Isoanticorpos/imunologia , Adolescente , Fatores de Coagulação Sanguínea/efeitos adversos , Fatores de Coagulação Sanguínea/uso terapêutico , Pré-Escolar , Fator IX/efeitos adversos , Fator IX/uso terapêutico , Fator VIII/efeitos adversos , Fator VIII/uso terapêutico , Hemofilia A/tratamento farmacológico , Hemofilia B/tratamento farmacológico , Humanos , Hipersensibilidade/diagnóstico , Tolerância Imunológica , Imunoglobulina E/imunologia , Masculino , Proteínas Recombinantes/efeitos adversos , Proteínas Recombinantes/uso terapêutico , Estudos Retrospectivos , Trombina/metabolismo
20.
s.l; s.n; 2020. 6 p.
Não convencional em Inglês | Sec. Est. Saúde SP, SESSP-ILSLPROD, Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1102327

RESUMO

Background: Kathon CG, a combination of methylchloroisothiazolinone and methylisothiazolinone, is widely used as preservative in cosmetics, as well in household cleaning products, industrial products such as paints and glues. It has emerged as an important sensitizing agent in allergic contact dermatitis. Objectives: This study evaluated the reactivity to this substance in patients subjected to patch tests at the Dermatology Institute in Bauru, São Paulo from 2015 to 2017 and its correlation with other preservatives, the professional activity and location of the lesions. Methods: The patients were submitted to standard series of epicutaneous tests, standardized by the Brazilian Group Studies on Contact Dermatitis. Results: Out the 267 patients tested, 192 presented positivity to at least one substance and 29 of the patients (15.10%) presented reaction to Kathon CG, with predominance of the female gender (n = 27); main professional activity associated with Kathon CG sensibilization was cleaning (17.24%), followed by aesthetic areas (13.79%) and health care (10.34%). The most prevalent sensitizations among the substances tested were nickel sulphate (56.3%), followed by cobalt chloride (23.4%), neomycin (18.2%), potassium dichromate (17.7%), thimerosal (14.5%), formaldehyde (13.2%), paraphenylenediamine (9.3%), and fragrance mix (8.3%). Study limitations: We do not have data from patients that were submitted to patch test a decade ago in order to confront to current data and establish whether or no sensitization to Kathon CG has increased. Conclusion: High positivity to Kathon CG corroborates the recent findings in the literature, suggesting more attention to concentration of this substance, used in cosmetics and products for domestic use.


Assuntos
Humanos , Masculino , Feminino , Dermatite de Contato/etiologia , Aditivos em Cosméticos , Hipersensibilidade/diagnóstico , Testes Cutâneos , Estudos Retrospectivos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA