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1.
BMJ Case Rep ; 12(7)2019 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-31352387

RESUMO

Takotsubo cardiomyopathy (TTC) is most commonly characterised by transient apical ballooning in response to physical or emotional stress without significant coronary artery disease (CAD). Various physical and emotional factors can trigger TTC. We report a case of hypothermia-induced biventricular TTC in an 84-year-old man admitted with a core body temperature of 29.8°C, followed by quick recovery of systolic function and resolution of wall motion abnormality after discharge. TTC should be suspected in hypothermic patients presenting with evidence of new onset heart failure and be added to the expanding list of factors triggering TTC. Similar to TTC induced by various other factors, hypothermia-induced TTC also carries a favourable prognosis with relatively quick recovery of wall motion abnormalities.


Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Temperatura Baixa/efeitos adversos , Hipotermia/complicações , Cardiomiopatia de Takotsubo/etiologia , Idoso de 80 Anos ou mais , Hidratação , Humanos , Hipotermia/fisiopatologia , Hipotermia/terapia , Masculino , Fatores Desencadeantes , Reaquecimento , Cardiomiopatia de Takotsubo/fisiopatologia , Cardiomiopatia de Takotsubo/terapia , Resultado do Tratamento
2.
Intern Med ; 58(18): 2743-2748, 2019 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-31178478

RESUMO

Accidental hypothermia is defined as a core body temperature <35°C. Even with the use of multiple active rewarming methods, it has a high mortality rate. No standard treatment strategy for moderate or severe hypothermia in the absence of cardiac arrest has yet been established. We herein report three patients with severe or moderate accidental hypothermia who were treated by hemodialysis in the acute phase. This case report with a literature review describes the usefulness of hemodialysis for the treatment of moderate and severe accidental hypothermia without cardiac arrest.


Assuntos
Hipotermia/terapia , Diálise Renal/métodos , Reaquecimento/métodos , Idoso , Arritmias Cardíacas/etiologia , Eletrocardiografia , Humanos , Hipotermia/complicações , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença
3.
Turk Kardiyol Dern Ars ; 47(4): 315-318, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31219440

RESUMO

An Osborn wave may be observed on an electrocardiogram (ECG) as a late delta wave at the end of the QRS complex in cases of hypothermia. An 18-year-old male known to be a synthetic cannabinoid user was found unconscious and hypothermic. The patient's body temperature was 33ºC, and an Osborn wave and atrial fibrillation were detected in ECG readings. Following the application of heating and supportive therapy, consciousness returned and the ECG findings improved. Rewarming and supportive treatment can be life-saving in a hypothermic patient when initiated as soon as possible.


Assuntos
Fibrilação Atrial/etiologia , Hipotermia/complicações , Hipotermia/etiologia , Abuso de Maconha/complicações , Adolescente , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/fisiopatologia , Gasometria , Temperatura Corporal , Eletrocardiografia , Emergências , Hidratação , Escala de Coma de Glasgow , Humanos , Masculino
4.
Artigo em Alemão | MEDLINE | ID: mdl-31212332

RESUMO

Persistent, uncontrolled bleeding after trauma is one of the leading causes of fatalities in patients with severe injuries. 40% of trauma deaths are associated with massive haemorrhage. Hypoperfusion due to major loss of blood volume leads to tissue damage. In combination with acidosis and hypothermia, a generalized immune response with activation of coagulation is triggered. This leads to trauma-induced coagulopathy. A suitable, early treatment might lead to a significant reduction in morbidity and mortality.


Assuntos
Acidose , Transtornos da Coagulação Sanguínea , Hemorragia , Hipotermia , Ferimentos e Lesões , Acidose/complicações , Coagulação Sanguínea , Transtornos da Coagulação Sanguínea/etiologia , Hemorragia/etiologia , Humanos , Hipotermia/complicações , Ferimentos e Lesões/complicações
6.
Am J Emerg Med ; 37(6): 1139-1143, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31006603

RESUMO

BACKGROUND: We sought to investigate risk factors for serious bacterial infection (SBI: bacterial meningitis, bacteremia, and urinary tract infection [UTI]) among infants ≤60 days of age presenting to the emergency department (ED) with hypothermia (temperature < 36 °C). METHODS: We performed a single center study over a 12-year period including all patients ≤60 days old with hypothermia, excluding patients who did not receive a blood culture and patients who received antibiotics prior to culture acquisition. The primary outcome was SBI. Secondary outcomes were mortality and herpes simplex infection. We performed multivariable logistic regression to identify risk factors for primary outcomes reporting adjusted odds ratios with 95% confidence intervals (aOR, 95% CI). RESULTS: 360 infants were identified. 10/360 (2.8%) had an SBI. All episodes of SBI occurred in infants ≤28 days of age. Two patients had meningitis, two had meningitis with bacteremia, one had isolated bacteremia, and five had UTI. Associated diagnoses included prematurity (46.9%), hyperbilirubinemia (28.3%) and dehydration (14.7%). In multivariable analysis, presentation at 15-28 days (7.60, 1.81-31.86; p = 0.005) compared to 0-14 days, higher absolute neutrophil count (1.25, 1.04-1.50; p = 0.015) and lower platelet count (0.99, 0.99-1.00; p = 0.046) were associated with SBI. Three patients without SBI died during or soon after their hospitalization. One patient had positive testing for herpes simplex. CONCLUSION: In this cohort of hypothermic infants, 2.8% had a SBI. Age of presentation, ANC, and lower platelet count were associated with serious infections. Hypothermic infants presenting to the ED carry significant morbidity and require prospective study to better risk-stratify this population.


Assuntos
Bactérias/isolamento & purificação , Infecções Bacterianas/diagnóstico , Infecções Bacterianas/epidemiologia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Hipotermia/complicações , Fatores Etários , Bacteriemia/diagnóstico , Bacteriemia/microbiologia , Sangue/microbiologia , Estudos de Coortes , Desidratação/epidemiologia , Feminino , Humanos , Hiperbilirrubinemia/epidemiologia , Lactente , Recém-Nascido , Recém-Nascido Prematuro , Contagem de Leucócitos , Modelos Logísticos , Masculino , Meningite/diagnóstico , Meningite/microbiologia , Análise Multivariada , Pennsylvania/epidemiologia , Contagem de Plaquetas , Fatores de Risco , Infecções Urinárias/diagnóstico , Infecções Urinárias/microbiologia
7.
Medicine (Baltimore) ; 98(6): e14392, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30732182

RESUMO

BACKGROUND: A majority of reports in the past decade have demonstrated that perioperative hypothermia increases susceptibility to surgical site infection (SSI). However, in recent years, an increasing number of studies did not find an association between hypothermia and the risk of SSI. These contradictory results have given rise to a conflicting issue on whether perioperative hypothermia is associated with SSI risk in surgical patients. METHODS: We examined the association between perioperative hypothermia and SSI incidence and then integrated available evidence by searching the databases, such as PubMed, Web of Science, Embase, and Cochrane library for potential papers from inception to April 2018. We included studies that reported original data or odds ratio (OR) with 95% confidence intervals (CIs) of the associations. Using fixed-effects models combined the OR with 95% CIs, randomized controlled trials and observational studies were analyzed, respectively, and cohort studies were further analyzed. Sensitivity analyses were performed by omitting each study iteratively, and publication bias was detected using Begg's tests. RESULTS: We screened 384 studies, and identified 8 eligible studies, including 2 randomized controlled trials and 6 observational studies (1 case-control study and 5 cohort studies). The pooled OR results in the randomized controlled studies showed that perioperative hypothermia could increase the risk of SSI without heterogeneity (OR, 1.60; 95% CI, 1.14-2.23; I = 0.0%, P = .845). The fixed-effect meta-analysis indicated no association between perioperative hypothermia and SSI risk in observational studies (OR, 0.98; 95% CI, 0.96-1.01; I = 53.2%, P = .058). Furthermore, cohort studies were performed to pool OR by using the fixed-effect model, and the incorporated results also suggested a similar relationship (OR, 1.13; 95% CI, 0.97-1.33; I = 46.4%, P = .113). CONCLUSION: The meta-analysis suggests that perioperative hypothermia is not associated with SSI in surgical patients. However, the 8 eligible studies were mostly cohort studies. Thus, further randomized controlled trials are required to confirm this finding.


Assuntos
Hipotermia/complicações , Infecção da Ferida Cirúrgica/epidemiologia , Infecção da Ferida Cirúrgica/etiologia , Adulto , Idoso , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Razão de Chances , Período Perioperatório , Fatores de Risco
8.
High Alt Med Biol ; 20(1): 71-77, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30801202

RESUMO

BACKGROUND: Because of the limited evidence available, recommendations for defibrillation of hypothermic patients vary among published guidelines. AIM: To report successful defibrillation of four severely hypothermic patients with witnessed cardiac arrest. RESULTS: During a four-year period from 2014 to 2017, four of five hypothermic patients admitted to our institution with a history of sudden, unexpected ventricular fibrillation (core temperature: 24°C-27°C) were successfully defibrillated. Restoration of spontaneous circulation (ROSC) was possible after a single defibrillator shock (two patients) or during prolonged advanced life support cardiopulmonary resuscitation (two patients). Our patients and additional cases identified in the literature indicate that successful defibrillation is predominantly found in hypothermic patients with a core temperature above 24°C. CONCLUSIONS: Our data demonstrate that successful defibrillation and ROSC are possible in selected patients with severe accidental hypothermia and are perhaps more common than widely believed. These findings are of particular importance for mountain and wilderness rescue missions when transfer of an arrested patient to the nearest hospital providing extracorporeal rewarming is not possible. An automatic external defibrillator should be part of the medical equipment on any search or mountain rescue mission, in which the victim may have sustained accidental hypothermia.


Assuntos
Reanimação Cardiopulmonar/métodos , Desfibriladores , Parada Cardíaca/terapia , Hipotermia/terapia , Adulto , Feminino , Parada Cardíaca/etiologia , Humanos , Hipotermia/complicações , Masculino , Pessoa de Meia-Idade , Reaquecimento/métodos , Resultado do Tratamento
9.
BMC Anesthesiol ; 19(1): 5, 2019 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-30621602

RESUMO

BACKGROUND: Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. However, sevoflurane has an antiarrhythmic effect associated with the connexin 43 (Cx43) protein that has not yet been fully established. METHODS: Hearts were divided into two groups according to a random number table: all hearts were arrested by an infusion of histidine-tryptophan-ketoglutarate (HTK) solution (4 °C) followed by (1) storage in HTK solution (4 °C) alone for 6 h (n = 8, Control group) or (2) storage in HTK solution supplemented with sevoflurane (2.5%) (4 °C) for 6 h (n = 8, Sevo-HTK group). First, the total Cx43 level and the phosphorylation of Cx43 at Ser368 (Cx43-pS368) were assessed by Western blotting, and the distribution of Cx43 was assessed by immunohistochemistry. Second, programmed electrical stimulation (PES) and monophasic action potential (MAP) recording were used to analyse the MAP duration (MAPD), conduction velocity (CV) and transmural repolarization dispersion (TDR). In addition, haematoxylin and eosin (HE) and terminal deoxynucleotidyl transferase-dUTP nick end labelling (TUNEL) staining were individually used to investigate the degree of myocardial pathological damage and cell apoptosis. Finally, bipolar electrograms were used to record the graft re-beating time and monitor RA during reperfusion for 15 to 30 min. RESULTS: Sevo-HTK solution relatively increased the total Cx43 (P < 0.01) and Cx43-pS368 (P < 0.01) levels and prevented Cx43 redistribution (P < 0.05) and CV slowing (P < 0.001) but did not change TDR (P > 0.05). Additionally, the Cx43-pS368/total Cx43 ratio (P>0.05) was similar in the two groups. However, with Sevo-HTK solution, the graft re-beating times were shortened, myocardial pathological damage was ameliorated, and the number of apoptotic cells was markedly decreased. CONCLUSION: The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368.


Assuntos
Antiarrítmicos/farmacologia , Arritmias Cardíacas/tratamento farmacológico , Isquemia Miocárdica/tratamento farmacológico , Sevoflurano/farmacologia , Animais , Arritmias Cardíacas/fisiopatologia , Conexina 43/metabolismo , Modelos Animais de Doenças , Junções Comunicantes/efeitos dos fármacos , Junções Comunicantes/metabolismo , Glucose/administração & dosagem , Hipotermia/complicações , Manitol/administração & dosagem , Camundongos , Traumatismo por Reperfusão Miocárdica/prevenção & controle , Fosforilação/efeitos dos fármacos , Cloreto de Potássio/administração & dosagem , Procaína/administração & dosagem , Remodelação Ventricular/efeitos dos fármacos
10.
Surg Infect (Larchmt) ; 20(3): 215-218, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30653405

RESUMO

BACKGROUND: Despite the indisputable need to prevent peri-operative hypothermia, some evidence in the literature questions the possible role of forced air warming systems as a risk factor for the occurrence of surgical site infection. The objective of the study is to evaluate the micro-biologic safety of a forced air warming systems (FAW) in relation to the risk of emission of micro-organisms in the surgical environment. METHODS: A quantitative, descriptive-exploratory laboratory study performed in a large hospital. An evaluation of possible internal contamination was performed by collecting air from the hose onto plates containing Trypticase Soy Agar. The experiment was performed in triplicate two months after replacing the filter and again after six months using a random sample of 50% of the FAW in use, which corresponded to 13 FAW and a total of 75 samples. RESULTS: Among the 39 samples analyzed in the first stage, only nine (23.1%) plates presented microbial growth of one or two colonies, while only six (16.7%) plates of the 36 evaluated samples in the second phase had growth of one or two colonies. CONCLUSIONS: This study showed small microbial growth of culture after 48 hours after filter replacement. New investigations that correlate the findings of micro-biology analysis and the occurrence of surgical site infection should be conducted.


Assuntos
Microbiologia do Ar , Calefação/efeitos adversos , Calefação/métodos , Hipotermia/complicações , Hipotermia/prevenção & controle , Período Intraoperatório , Infecção da Ferida Cirúrgica/epidemiologia , Ar , Estudos de Avaliação como Assunto , Humanos , Infecção da Ferida Cirúrgica/prevenção & controle
11.
Am J Emerg Med ; 37(2): 189-193, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-29764735

RESUMO

BACKGROUND: Pancreatic damage is commonly observed as a consequence of accidental hypothermia (core body temperature below 35 °C). We aimed to investigate the risk factors for pancreatic damage and the causal relationship in patients with accidental hypothermia. METHODS: This retrospective, single-center, observational case-control study was conducted in the emergency department of a tertiary care medical center. We investigated patients who were admitted for accidental hypothermia over a course of ten years (January 2008 to December 2017). RESULTS: Of the 138 enrolled patients, 70 had elevated serum amylase levels (51%). We observed a correlation between initial core body temperature and serum amylase level (Spearman's rank correlation coefficient -0.302, p < 0.001). Patients who developed acute pancreatitis had a significantly lower initial core body temperature than those who did not develop it (odds ratio = 0.76; 95% confidence interval [CI] = 0.61-0.94; p = 0.011). Receiver operating characteristic analysis showed that a body temperature lower than 28.5 °C at the time of visit was predictive of acute pancreatitis (area under the curve = 0.71, 95% CI = 0.54-0.88, sensitivity = 0.67, specificity = 0.69, p = 0.017). CONCLUSIONS: We concluded that an initial core body temperature lower than 28.5 °C was a risk factor for acute pancreatitis in accidental hypothermia cases. In such situations, careful follow-up is necessary.


Assuntos
Hipotermia/complicações , Pancreatite/etiologia , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Amilases/sangue , Temperatura Corporal , Estudos de Casos e Controles , Diagnóstico Precoce , Serviço Hospitalar de Emergência , Feminino , Humanos , Hipotermia/etiologia , Masculino , Pessoa de Meia-Idade , Pancreatite/diagnóstico por imagem , Pancreatite/enzimologia , Estudos Retrospectivos , Fatores de Risco , Tomografia Computadorizada por Raios X , Adulto Jovem
13.
Rev Bras Anestesiol ; 69(1): 78-81, 2019.
Artigo em Português | MEDLINE | ID: mdl-29559182

RESUMO

BACKGROUND: Livedo reticularis is a benign dermatological condition characterized by ischemic areas permeated by erythematous-cyanotic areas in a lacy pattern, and may be transient or permanent and is frequently associated with body exposure to cold. Cutaneous arterial vasospasm promotes ischemia, and venous dilation of the congested areas occurs by tissue hypoxia or autonomic dysfunction. Patients with Down's syndrome, due to their physiological peculiarities, constitute a representative part of those who require dental care under general anesthesia, and livedo reticularis has a reported incidence of 8% to 12% in Down's syndrome patients. OBJECTIVES: To describe the physiological livedo reticularis in a Down's syndrome patient, with the onset during the anesthetic-surgical procedure. CASE REPORT: 5-year-old female patient with Down's syndrome, admitted for dental treatment under balanced general anesthesia with sevoflurane, fentanyl, and atracurium. Transoperative hypothermia occurred with axillary temperature reaching 34.5°C after 30minutes after the beginning of anesthesia. At the end of the procedure, red-purplish skin lesions interspersed with areas of pallor were observed exclusively on the ventromedial aspect of the right forearm, with no systemic signs suggestive of allergic reactions. The established diagnosis was physiological livedo reticularis. There was a total fading of the lesions within 5 days. CONCLUSION: This report evidences the need for thermal control of patients undergoing anesthesia, as well as the manifestation of livedo reticularis as a consequence of transoperative hypothermia.


Assuntos
Anestesia Dentária , Assistência Odontológica , Síndrome de Down/complicações , Hipotermia/complicações , Livedo Reticular/etiologia , Pré-Escolar , Feminino , Humanos
14.
Ther Hypothermia Temp Manag ; 9(1): 86-89, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30096259

RESUMO

We describe a patient with severe accidental hypothermia (≤25.4°C) and prolonged refractory ventricular fibrillation, lasting at least 4 hours and 8 minutes, who underwent cardiopulmonary resuscitation with extracorporeal membrane oxygenation and survived without neurologic deficit.


Assuntos
Reanimação Cardiopulmonar/métodos , Oxigenação por Membrana Extracorpórea/métodos , Hipotermia/terapia , Fibrilação Ventricular/terapia , Acidentes , Humanos , Hipotermia/complicações , Masculino , Pessoa de Meia-Idade , Reaquecimento , Resultado do Tratamento , Fibrilação Ventricular/complicações
15.
Ann Emerg Med ; 73(1): 52-57, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30420231

RESUMO

We describe full neurologic recovery from accidental hypothermia with cardiac arrest despite the longest reported duration of mechanical cardiopulmonary resuscitation (CPR) and extracorporeal life support (8 hours, 42 minutes). Clinical data and blood samples were obtained from emergency medical services (EMS) and the intensive care department. A 31-year-old man experienced a witnessed hypothermic cardiac arrest with a core temperature of 26°C (78.8°F) during a summer thunderstorm; he received mechanical CPR for 3 hours and 42 minutes, followed by 5 hours of extracorporeal life support. The use of a standard operating procedure that integrates a technical mountain rescue performed by EMS, optimizes prolonged CPR to the hub hospital, and enables prompt placement of extracorporeal life support is described and discussed. Three months postaccident, the patient had recovered completely (Cerebral Performance Category score of 1) and resumed normal daily life. Neurologically intact survival from hypothermic cardiac arrest is common, suggesting that aggressive resuscitation measures are warranted. There is a need for the establishment of a clear standard operating procedure and multiteam education and training to further optimize the patient survival chain from on-site triage and treatment to inhospital extracorporeal life support and postresuscitation care.


Assuntos
Reanimação Cardiopulmonar/métodos , Oxigenação por Membrana Extracorpórea/métodos , Parada Cardíaca/terapia , Hipotermia/complicações , Atividades Cotidianas , Adulto , Serviços Médicos de Emergência , Parada Cardíaca/etiologia , Humanos , Hipotermia/etiologia , Masculino , Recuperação de Função Fisiológica , Fatores de Tempo , Tempo (Meteorologia)
17.
Handb Clin Neurol ; 157: 565-597, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30459026

RESUMO

Systemic inflammation-associated syndromes (e.g., sepsis and septic shock) often have high mortality and remain a challenge in emergency medicine. Systemic inflammation is usually accompanied by changes in body temperature: fever or hypothermia. In animal studies, systemic inflammation is often modeled by administering bacterial lipopolysaccharide, which triggers autonomic and behavioral thermoeffector responses and causes either fever or hypothermia, depending on the dose and ambient temperature. Fever and hypothermia are regulated changes of body temperature, which correspond to mild and severe forms of systemic inflammation, respectively. Mediators of fever and hypothermia are called endogenous pyrogens and cryogens; they are produced when the innate immune system recognizes an infectious pathogen. Upon an inflammatory challenge, hepatic and pulmonary macrophages (and later brain endothelial cells) start to release lipid mediators, of which prostaglandin (PG) E2 plays the key role, and cytokines. Blood PGE2 enters the brain and triggers fever. At later stages of fever, PGE2 synthesized within the blood-brain barrier maintains fever. In both cases, PGE2 is synthesized by cyclooxygenase-2 and microsomal PGE2synthase-1. Mediators of hypothermia are not well established. Both fever and hypothermia are beneficial host defense responses. Based on evidence from studies in laboratory animals and clinical trials in humans, fever is beneficial for fighting mild infection. Based mainly on animal studies, hypothermia is beneficial in severe systemic inflammation and infection.


Assuntos
Febre/complicações , Hipotermia/complicações , Síndrome de Resposta Inflamatória Sistêmica/complicações , Animais , Regulação da Temperatura Corporal , Dinoprostona/sangue , Humanos , Fígado/patologia , Macrófagos/patologia
18.
Handb Clin Neurol ; 157: 687-697, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30459033

RESUMO

Perioperative hypothermia is common, with an incidence ranging between 20 and 70%, and is defined by a body core temperature below 36.0°C. Perioperative warming was rare during the previous century, but was subsequently identified as a significant contributor to perioperative morbidity and mortality. Perioperative hypothermia causes impaired pharmacodynamics, surgical site infections, blood loss and coagulopathy, transfusion requirements, thermal discomfort, prolonged recovery, and prolonged duration of hospitalization. Measurement of central core temperature, maintaining normothermia, and consequent warming of patients in the perioperative period are therefore essential. Several warming devices are commercially available, including active skin warming as the most efficient, inexpensive, easy-to-use and mostly having a good cost/benefit ratio for the majority of patients and surgeries.


Assuntos
Regulação da Temperatura Corporal/fisiologia , Hipotermia/complicações , Hipotermia/etiologia , Período Perioperatório , Humanos
19.
Handb Clin Neurol ; 157: 727-735, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30459036

RESUMO

Alzheimer disease (AD), which is associated with chronic and progressive neurodegeneration, is the most prevalent cause of dementia linked to aging. Among the risk factors for AD, age stands as the greatest one, with the vast majority of people with AD being 65 years of age or older. Nevertheless, the pathophysiologic mechanisms underlying the link between aging and the development of AD, although not completely understood, might reveal important aspects for the understanding of this pathology. Thus, there is significant evidence that the impaired thermal homeostasis associated with normal aging leads to a variety of metabolic changes that could be associated with AD development. In this chapter, we assess the clinical and biochemical evidence implicating hypothermia as a risk factor for the development of AD and the impact of hypothermia on the two pathologic hallmarks of AD: accumulation of senile plaques of amyloid-beta and neurofibrillary tangles of aberrant hyperphosphorylated tau protein.


Assuntos
Doença de Alzheimer , Hipotermia/complicações , Doença de Alzheimer/etiologia , Doença de Alzheimer/metabolismo , Doença de Alzheimer/patologia , Peptídeos beta-Amiloides/metabolismo , Humanos , Emaranhados Neurofibrilares/patologia , Placa Amiloide/etiologia , Fatores de Risco , Proteínas tau/metabolismo
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