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1.
J Law Med ; 27(1): 50-54, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31682341

RESUMO

In R (on the application of British Homeopathic Association) v National Health Service Commissioning Board [2018] EWHC 1359 (Admin) Supperstone J of the High Court of England and Wales delivered an internationally significant judgment on the processes required to be engaged in when guidance is given to medical practitioners about their involvement in homeopathic prescribing. This column explores the bases upon which the challenge by the British Homeopathic Association was lost and the repercussions of the judgment for the practice of non-evidence-based modalities, such as homeopathy.


Assuntos
Homeopatia , Legislação Médica , Inglaterra , Programas Nacionais de Saúde , País de Gales
2.
Prensa méd. argent ; 105(10): 686-692, oct 2019.
Artigo em Inglês | LILACS, BINACIS | ID: biblio-1025966

RESUMO

This paper explains the elementary law of homeopathy, the Law of Similars, on the bases of thermodynamic aspects by means of the chemical thermodynamic. Le Chatelier principle was used, to explain the re-establishment of starting biochemical equilibrium compartmentalized in individual human cells of an ill person consuming the remedy, to clarify the Law of Similars. In addition, the application of the Law of mass action during the re-establishment of the initial equilibrium in an ill person when digesting the remedy exposed the law of Similars as the strongest outcome of homeopathy


Assuntos
Humanos , Fenômenos Bioquímicos , Ação Farmacodinâmica do Medicamento Homeopático , Fundamentos da Homeopatia/história , Lei dos Semelhantes , Homeopatia/história
3.
Cochrane Database Syst Rev ; 9: CD009710, 2019 09 04.
Artigo em Inglês | MEDLINE | ID: mdl-31483486

RESUMO

BACKGROUND: Irritable bowel syndrome (IBS) is a common, chronic disorder that leads to decreased health-related quality of life and work productivity. A previous version of this review was not able to draw firm conclusions about the effectiveness of homeopathic treatment for IBS and recommended that further high quality RCTs were conducted to explore the clinical and cost effectiveness of homeopathic treatment for IBS. Two types of homeopathic treatment were evaluated in this systematic review: 1. Clinical homeopathy where a specific remedy is prescribed for a specific condition; 2. Individualised homeopathic treatment, where a homeopathic remedy based on a person's individual symptoms is prescribed after a detailed consultation. OBJECTIVES: To assess the effectiveness and safety of homeopathic treatment for IBS. SEARCH METHODS: For this update we searched MEDLINE, CENTRAL, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Allied and Complementary Medicine Database (AMED), the Cochrane IBD Group Specialised Register and trials registers from inception to 31 August 2018. SELECTION CRITERIA: Randomised controlled trials (RCTs), cohort and case-control studies that compared homeopathic treatment with placebo, other control treatments, or usual care, in adults with IBS were considered for inclusion. DATA COLLECTION AND ANALYSIS: Two authors independently assessed the risk of bias and extracted data. The primary outcome was global improvement in IBS as measured by an IBS symptom severity score. Secondary outcomes included quality of life, abdominal pain, stool frequency, stool consistency, and adverse events. The overall certainty of the evidence supporting the primary and secondary outcomes was assessed using the GRADE criteria. We used the Cochrane risk of bias tool to assess risk of bias. We calculated the mean difference (MD) and 95% confidence interval (CI) for continuous outcomes and the risk ratio (RR) and 95% CI for dichotomous outcomes. MAIN RESULTS: Four RCTs (307 participants) were included. Two studies compared clinical homeopathy (homeopathic remedy, asafoetida or asafoetida plus nux vomica) to placebo for IBS with constipation (IBS-C). One study compared individualised homeopathic treatment (consultation plus remedy) to usual care for the treatment of IBS in female patients. One study was a three armed RCT comparing individualised homeopathic treatment to supportive listening or usual care. The risk of bias in three studies (the two studies assessing clinical homeopathy and the study comparing individualised homeopathic treatment to usual care) was unclear on most criteria and high for selective reporting in one of the clinical homeopathy studies. The three armed study comparing individualised homeopathic treatment to usual care and supportive listening was at low risk of bias in four of the domains and high risk of bias in two (performance bias and detection bias).A meta-analysis of the studies assessing clinical homeopathy, (171 participants with IBS-C) was conducted. At short-term follow-up of two weeks, global improvement in symptoms was experienced by 73% (46/63) of asafoetida participants compared to 45% (30/66) of placebo participants (RR 1.61, 95% CI 1.18 to 2.18; 2 studies, very low certainty evidence). In the other clinical homeopathy study at two weeks, 68% (13/19) of those in the asafoetida plus nux vomica arm and 52% (12/23) of those in the placebo arm experienced a global improvement in symptoms (RR 1.31, 95% CI 0.80 to 2.15; very low certainty evidence). In the study comparing individualised homeopathic treatment to usual care (N = 20), the mean global improvement score (feeling unwell) at 12 weeks was 1.44 + 4.55 (n = 9) in the individualised homeopathic treatment arm compared to 1.41 + 1.97 (n=11) in the usual care arm (MD 0.03; 95% CI -3.16 to 3.22; very low certainty evidence).In the study comparing individualised homeopathic treatment to usual care, the mean IBS symptom severity score at 6 months was 210.44 + 112.4 (n = 16) in the individualised homeopathic treatment arm compared to 237.3 + 110.22 (n = 60) in the usual care arm (MD -26.86, 95% CI -88.59 to 34.87; low certainty evidence). The mean quality of life score (EQ-5D) at 6 months in homeopathy participants was 69.07 (SD 17.35) compared to 63.41 (SD 23.31) in usual care participants (MD 5.66, 95% CI -4.69 to 16.01; low certainty evidence).For In the study comparing individualised homeopathic treatment to supportive listening, the mean IBS symptom severity score at 6 months was 210.44 + 112.4 (n = 16) in the individualised homeopathic treatment arm compared to 262 + 120.72 (n = 18) in the supportive listening arm (MD -51.56, 95% CI -129.94 to 26.82; very low certainty evidence). The mean quality of life score at 6 months in homeopathy participants was 69.07 (SD 17.35) compared to 63.09 (SD 24.38) in supportive listening participants (MD 5.98, 95% CI -8.13 to 20.09; very low certainty evidence).None of the included studies reported on abdominal pain, stool frequency, stool consistency, or adverse events. AUTHORS' CONCLUSIONS: The results for the outcomes assessed in this review are uncertain. Thus no firm conclusions regarding the effectiveness and safety of homeopathy for the treatment of IBS can be drawn. Further high quality, adequately powered RCTs are required to assess the efficacy and safety of clinical and individualised homeopathy for IBS compared to placebo or usual care.


Assuntos
Homeopatia/métodos , Síndrome do Intestino Irritável/terapia , Fitoterapia/métodos , Constipação Intestinal/etiologia , Constipação Intestinal/terapia , Fibras na Dieta/uso terapêutico , Feminino , Humanos , Masculino , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto
4.
Recurso na Internet em Espanhol | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-46739

RESUMO

Hablando de Homeopatía nace como UNA RESPUESTA A LA DEMANDA CRECIENTE DE INFORMACIÓN FIABLE, VERAZ Y RIGUROSA SOBRE LA HOMEOPATÍA por parte de profesionales y pacientes.


Assuntos
Homeopatia , Terapêutica Homeopática , Clínica Homeopática
5.
Recurso na Internet em Espanhol | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-46651

RESUMO

La Asamblea Nacional de Homeopatía (ANH) es la entidad que agrupa y representa a las sociedades médicas, veterinarias y farmacéuticas de nuestro país ante otras asociaciones nacionales e internacionales, instituciones y poderes públicos. informacion@homeopatiasuma.com


Assuntos
Homeopatia
7.
Acta Vet Scand ; 61(1): 30, 2019 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-31300066

RESUMO

BACKGROUND: Veterinary remedies are intended to support animals in their recovery from diseases. Treatment outcome depends not only on the general effectiveness of the remedies themselves, but also on other prerequisites. This is true for antibiotics, but even more so for treatments with homeopathic products which are characterised by their individualised approach. While the effectiveness of homeopathy has been addressed in various clinical control trials, the practical conditions under which homeopathic products are used on dairy farms have not yet been investigated. This study provides an initial insight into the existing prerequisites on dairy farms for the use of homeopathy (i.e. the consideration of homeopathic principles) and on homeopathic treatment procedures (including anamnesis, clinical examination, diagnosis, selection of a remedy, follow-up checks, and documentation) on 64 dairy farms in France, Germany and Spain. The use of homeopathy was assessed via a standardised questionnaire during face-to-face interviews. RESULTS: The study revealed that homeopathic treatment procedures were applied very heterogeneously and differed considerably between farms and countries. Farmers also use human products without veterinary prescription as well as other prohibited substances. CONCLUSIONS: The subjective treatment approach using the farmers' own criteria, together with their neglecting to check the outcome of the treatment and the lack of appropriate documentation is presumed to substantially reduce the potential for a successful recovery of the animals from diseases. There is, thus, a need to verify the effectiveness of homeopathic treatments in farm practices based on a lege artis treatment procedure and homeopathic principles which can be achieved by the regular monitoring of treatment outcomes and the prevailing rate of the disease at herd level. Furthermore, there is a potential risk to food safety due to the use of non-veterinary drugs without veterinary prescription and the use of other prohibited substances.


Assuntos
Doenças dos Bovinos/terapia , Indústria de Laticínios/estatística & dados numéricos , Homeopatia/veterinária , Animais , Bovinos , Feminino , França , Alemanha , Homeopatia/estatística & dados numéricos , Espanha , Inquéritos e Questionários
8.
J Med Life ; 12(1): 49-55, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31123525

RESUMO

Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative Rapidly Progressive Glomerulonephritis (RPGN) is a severe form of autoimmune renal injury with a bleak prognosis. A 60-year-old Indian woman was treated with classical homeopathy for ANCA-negative RPGN, and after one year of treatment, serum creatinine and other parameters indicating renal injury dropped steadily despite the withdrawal of immunosuppressive drugs; renal dialysis, which was conducted twice a week initially, was made rarer and stopped after one year. Classical homeopathy may be considered a potential therapeutic modality in severe pathologies. Controlled studies are required to establish further the extent to which classical homeopathy may relieve patients from procedures such as dialysis that cause considerable physical and economic discomfort.


Assuntos
Anticorpos Anticitoplasma de Neutrófilos/metabolismo , Progressão da Doença , Glomerulonefrite/imunologia , Glomerulonefrite/patologia , Homeopatia , Medicina de Precisão , Insuficiência Renal/complicações , Feminino , Glomerulonefrite/complicações , Glomerulonefrite/diagnóstico , Humanos , Pessoa de Meia-Idade , Diálise Renal
9.
Oncology ; 97(1): 18-25, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31132779

RESUMO

PURPOSE: It is usual for cancer patients to use complementary and alternative medicines (CAMs) and yet the literature evaluating their efficacy in cancer patients is very limited. The objective of the present study was to report on the nature, frequency of use, and patient-reported outcome of CAMs in a single-center study. METHODS: All the consecutive patients treated between November 2017 and June 2018 at the Lucien Neuwirth Cancer Institute (France) were screened. Their reasons for using CAMs and their usage habits were collected. Patients evaluated their benefit. RESULTS: Of the 209 patients screened, 200 patients were included. CAMs ranged from osteopathy, homeopathy, acupuncture, healing touch, magnetism, naturopathy, suction cups, Chinese medicine, reflexology, to hypnosis. CAMs were widely used (n = 166, 83%), the first being osteopathy (n = 99, 49.5%), the second homeopathy (n = 78, 39.0%), and finally acupuncture (n = 76, 38.0%). Whatever the CAM, high satisfaction rates were reported (median satisfaction: 61-81%). CAMs were mainly used to prevent/treat side effects of anticancer treatments (81.2% for healing touch), increase well-being (55.4% for naturopathy), improve the immune system (16.9% for homeopathy), and treat cancer (n = 3, 5.1% for homeopathy). Patients could easily consider using CAMs, as up to 50.8% would have accepted a consultation. CONCLUSIONS: The reasons for using CAMs differed among patients. They praised CAMs and kept asking for more information although there is limited evidence about their efficacy in the literature. Thus, prospective randomized controlled trials exploring the safety and efficacy of CAMs in cancer patients are needed.


Assuntos
Terapia por Acupuntura/métodos , Terapias Complementares/métodos , Medicina Tradicional Chinesa/métodos , Neoplasias/terapia , Terapias Complementares/psicologia , Feminino , França/epidemiologia , Homeopatia/métodos , Humanos , Hipnose/métodos , Masculino , Massagem/métodos , Naturopatia/métodos , Neoplasias/epidemiologia , Neoplasias/patologia , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Satisfação do Paciente , Resultado do Tratamento
10.
Bull Cancer ; 106(5): 479-491, 2019 May.
Artigo em Francês | MEDLINE | ID: mdl-31023481

RESUMO

Complementary and alternative medicines (CAMs) play more and more a significant role both in France and all over the world. Yet, their definition and their role in cancer treatments legitimately raise concerns. This article aims at establishing a picture of the CAMs admitted by the French Medical Board as well as those which are new or in common medical practices in France. We start with a brief reminder of their origin, their status and how they are used. Then, we review the literature about some of the best clinical trials using CAMs in cancer patients. To finish, we try to understand what makes CAMs so thrilling, but also why they create controversy and which common points they may have with conventional medicine.


Assuntos
Terapias Complementares , Neoplasias/terapia , Terapia por Acupuntura , Homeopatia , Humanos
11.
Braz Dent J ; 30(2): 139-145, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30970056

RESUMO

Chronic periodontitis (CP) and Diabetes mellitus type 2 (DMII) are chronic diseases usually treated by conventional practices. On the other hand, homeopathy can help to treat many different diseases. The aim of this study was to evaluate the effects of homeopathy (H) as an adjunct for non-surgical periodontal therapy (NSPT) in individuals with DMII and CP. Eighty individuals with CP and DM II, of both sexes and aged between 32 and 70 years, participated in this randomized, double-blind, placebo-controlled study. They were divided into two groups: control group (CG) and the test group (TG), and both groups received the NSPT. TG also received homeopathic therapy, including Berberis, Mercurius solubilis/Belladonna/Hepar sulphur and Pyrogenium, while CG received placebo. Clinical and laboratorial examinations were evaluated at baseline and after 1, 6 and 12 months of treatment. Both groups showed significant improvement throughout the study, for most of the parameters studied, but TG presented significative gain of CAL at 1 and 12 months compared to CG. Mean glucose and glycated hemoglobin significantly decreased in both groups after 6 and 12 months. However, there was a significantly further reduction of these parameters in TG, as compared to CG. In conclusion, homeopathy as supplement of NSPT may further improve health condition, including glycemic control, in DMII patients with CP.


Assuntos
Periodontite Crônica , Diabetes Mellitus Tipo 2 , Homeopatia , Adulto , Idoso , Raspagem Dentária , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice Periodontal
12.
Complement Ther Med ; 43: 53-59, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30935555

RESUMO

BACKGROUND: Insomnia is the most common sleep-related complaint associated with impaired day-time functioning, reduced quality of life, increased morbidity and substantial societal cost. We evaluated whether individualized homeopathy (IH) could produce significant effect beyond placebo in treatment of insomnia. METHODS: In this double-blind, randomized, placebo-controlled, two parallel arms trial, 60 patients were randomized to receive either IH/verum or control/placebo (1:1). Patient-administered sleep diary (6 items; 1: latency to fall asleep, 2: minutes awake in middle of night, 3: minutes awake too early, 4: hours spent in bed, 5: total sleep time in hours, and 6: sleep efficiency) and Insomnia Severity Index (ISI) were taken as the primary and secondary outcomes respectively, measured at baseline, and after 3 months. RESULTS: Five patients dropped out (verum: 2, control: 3). Intention to treat sample (n = 60) was analyzed. Trial arms were comparable at baseline. In the verum group, except sleep diary item 3 (P = 0.371), rest of the outcomes improved significantly (all P < 0.01). In the control group, there were significant improvements in diary item 6 and ISI score (P < 0.01) and just significant improvement in item 5 (P = 0.018). Group differences were significant for items 4, 5 and 6 (P < 0.01) and just significant (P = 0.014) for ISI score with moderate to large effect sizes; but non-significant (P > 0.01) for rest of the outcomes. CONCLUSION: IH seemed to produce significantly better effect than placebo. Rigorous trials and independent replications are warranted.


Assuntos
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico , Adulto , Método Duplo-Cego , Feminino , Homeopatia/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Qualidade de Vida , Sono/efeitos dos fármacos , Resultado do Tratamento , Adulto Jovem
13.
Homeopatia Méx ; 88(716): 5-27, jan. - marc. 2019. tab
Artigo em Espanhol | LILACS, HomeoIndex - Homeopatia | ID: biblio-995981

RESUMO

A tres décadas de la publicación del artículo científico que divulgó internacionalmente las investigaciones dirigidas por el doctor Jacques Benveniste en torno a la degranulación de basófilos disparada por anticuerpos altamente diluidos (fenómeno conocido de manera coloquial como "la memoria del agua"), el doctor Bernard Poitevin, quien fue colaborador en dichos estudios científicos, expone en este artículo su versión de la historia y sus puntos de vista sobre este episodio de especial trascendencia para la Homeopatía. En ese sentido, el presente documento nos contextualiza en el panorama que se vivía en torno a la medicina hahnemanniana en Francia desde finales de la década de 1970 y nos muestra ciertos detalles poco recordados sobre el trabajo de Benveniste: cómo se definió la metodología de la investigación, la forma en que se constituyó el equipo de trabajo y el papel que desempeñaron la industria farmacéutica homeopática, el sistema de salud francés y un lobby o grupo de presión contrario a la Homeopatía. Más aún, el artículo nos presenta al doctor Benveniste sin idealizaciones y nos sugiere que ciertos rasgos de su personalidad pudieron influir en el desarrollo de sus investigaciones y en la presentación de los resultados ante la comunidad científica, lo que a su vez pudo repercutir en las discusiones mediáticas que sucedieron en los siguientes años y cuyas consecuencias persisten hasta nuestros días. (AU)


Three decades after the publication of the scientific article on the research conducted by Dr. Jacques Benveniste on the degranulation of basophils triggered by highly diluted antibodies (a phenomenon known colloquially as "the memory of water"), Dr. Bernard Poitevin, who collaborated in the realization of such scientific studies, exposes in this article his version of history and his views on this episode of special significance for the Homeopathy. In this sense, the present document contextualizes us in the panorama that was lived around the Hahnemannian medicine in France since the end of the 1970s and shows us certain little-remembered details about the work directed by Benveniste: how the research methodology was defined, the way the research group was constituted and the role played by the homeopathic pharmaceutical industry, the health system of France and a lobby against Homeopathy. Moreover, the article presents a Dr. Benveniste without idealizations and suggests that certain features of his personality could influence the development of his research and the presentation of results to the scientific community, which in turn could affect the media discussions that happened in the following years and whose consequences persist to this day. (AU)


Assuntos
Altas Potências/história , Mecanismo de Ação do Medicamento Homeopático , História , Homeopatia , Medicina Baseada em Evidências
14.
Homeopatia Méx ; 88(716): 28-35, jan. - marc. 2019. graf, tab
Artigo em Espanhol | LILACS, HomeoIndex - Homeopatia | ID: biblio-995982

RESUMO

La terapia hormonal es el tratamiento convencional para contrarrestar síntomas propios del climaterio; sin embargo, algunas mujeres tienen contraindicada esta terapia debido a los efectos adversos que provoca. El objetivo de este estudio fue evaluar la utilidad del tratamiento homeopático durante el climaterio con el uso de la Menopause Rating Scale (MRS) o Escala de Calificación Menopáusica. El estudio incluyó a 31 mujeres, sin problemas cardiacos, sin terapia de reemplazo hormonal y sin antecedentes de cáncer, a quienes se les aplicó el cuestionario de la MRS para obtener un puntuaje antes del tratamiento. Para determinar el tratamiento se utilizó el repertorio electrónico Radar 10.0 para Windows, con el objetivo de repertorizar los síntomas característicos de cada paciente y determinar el medicamento similar. El medicamento fue prescrito en dinamizaciones 30CH, indicando 5 gotas sublinguales cada 8 horas. La evaluación de los pacientes se llevó a cabo cada mes durante tres meses. Se realizó una evaluación final a los tres meses por comparación de puntajes de la escala inicial y final, a través de un análisis estadístico y utilizando la prueba de Wilcoxon. Lachesis trigonocephalus y Pulsatilla nigricans fueron los medicamentos indicados con mayor frecuencia, de acuerdo con los síntomas de cada paciente. La comparación del puntaje, antes y después del tratamiento, evidenció una reducción de síntomas con diferencia estadística, lo cual reflejó una mejoría global del 35%. Esta evidencia sugiere que el tratamiento homeopático beneficia a las mujeres en el climaterio. (AU)


Hormonal therapy is the conventional treatment for counteracting climacteric symptoms; however, this treatment is contraindicated in some women due to the adverse effects that this therapy may cause. The purpose of this study was to evaluate the usefulness of homeopathic therapy during the climacteric using the Menopause Rating Scale (MRS). The study included 31 women, without cardiac problems, history of no cancer or hormone replacement therapy; a MRS scale questionnaire was applied to these women to evaluate each symptom before to treatment. The Radar 10.0 for Windows electronic repertoire was used to repertorize the characteristic symptoms of each patient and determine the similarly. Homeopathic medication was prescribed in 30CH dynamization as 5 sublingual drops every 8 hrs. Patient evaluation took place monthly for 3 months. The evaluation of the results was performed by the comparison of scale scores through a statistical analysis using the Wilcoxon test. Lachesis trigonocephalus and Pulsatilla nigricans were the most frequent treatment indications, according to the symptoms of each patient. At the end of the homeopathic treatment, symptoms reduction was observed with statistical significance in the score, which reflects an overall improvement of 35%. This evidence suggested that homeopathic treatment benefits women in climacteric. (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Climatério , Menopausa , Saúde da Mulher , Perimenopausa , Homeopatia , Pulsatilla nigricans/uso terapêutico , Lachesis muta/uso terapêutico
15.
Homeopatia Méx ; 88(716): 36-43, jan. - marc. 2019.
Artigo em Espanhol | LILACS, HomeoIndex - Homeopatia | ID: biblio-995983

RESUMO

En este ensayo-reportaje se hace un recorrido a través de algunos de los momentos más significativos en la historia de la Homeopatía en México, desde sus orígenes hasta las primeras décadas del siglo XXI. Además de recordar la fundación de las instituciones más significativas para el gremio médico homeopático y su relación con el trabajo de algunos médicos connotados, se mencionan algunas investigaciones científicas de relevancia, las aportaciones reales y potenciales de la medicina hahnemanniana a la salud pública y la influencia que la Homeopatía mexicana ha tenido, principalmente en países hispanohablantes. (AU)


This essay-report presents a review of the most significant moments of homeopathy in Mexico, from its origins to the first decades of the 21st century. He recalls the founding of the most significant institutions for the homeopathic profession and its relationship with the work of some connoted doctors; also mentioned are relevant scientific researchs, the contributions of the hahnemannian medicine to public health and the influence of the Mexican homeopathy, mainly in Ibero-America. (AU)


Assuntos
Instituições Acadêmicas , Saúde Pública , Homeopatia/história , México
16.
Complement Med Res ; 26(2): 111-117, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30893676

RESUMO

Homeopathy is a controversial form of complementary therapy, but is widely practised to treat asthma. The aim of this systematic review is to evaluate the controlled trials of homeopathy in bronchial asthma. Relevant trials published between Jan 1, 1981, and Dec 31, 2016, were considered. Substantive research articles, conference proceedings, and master and doctoral theses were eligible. Methodology was assessed by Jadad's scoring, internal validity by the Coch-rane tool, model validity by Mathie's criteria, and quality of individualization by Saha's criteria. Sixteen trials were eligible. The majority were positive, especially those testing complex formulations. Methodological quality was diverse; 8 trials had "high" risk of bias. Model validity and individualization quality were compromised. Due to both qualitative and quantitative inadequacies, proofs supporting individualized homeopathy remained inconclusive. The trials were positive (evidence level A), but inconsistent, and suffered from methodological heterogeneity, "high" to "uncertain" risk of bias, incomplete study reporting, inadequacy of independent replications, and small sample sizes.


Assuntos
Asma , Homeopatia/estatística & dados numéricos , Ensaios Clínicos Controlados como Assunto , Humanos , Modelos Estatísticos
17.
Phytomedicine ; 58: 152869, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30831467

RESUMO

PURPOSE: The present randomized controlled clinical trial evaluated the efficacy of homeopathic medicines of Melissa officinalis (MO), Phytolacca decandra (PD), and the combination of both in the treatment of possible sleep bruxism (SB) in children. STUDY DESIGN: Patients (n = 52) (6.62 ± 1.79 years old) were selected based on the parents report of SB. The study comprised a crossover design that included 4 phases of 30-day treatment (Placebo; MO 12c; PD 12c; and MO 12c + PD 12c), with a wash-out period of 15 days between treatments. METHODS: At baseline and after each phase, the Visual Analogic Scale (VAS) was used as the primary outcome measure to evaluate the influence of treatments on the reduction of SB. The following additional outcome measures were used: a children's sleep diary with parent's/guardian's perceptions of their children's sleep quality, the trait of anxiety scale (TAS) to identify changes in children's anxiety profile, and side effects reports. Data were analyzed by ANOVA with repeated measures followed by Post Hoc LSD test. RESULTS: Significant reduction of SB was observed in VAS after the use of Placebo (-1.72 ± 0.29), MO (-2.36 ± 0.36), PD (-1.44 ± 0.28) and MO + PD (-2.21 ± 0.30) compared to baseline (4.91 ± 1.87). MO showed better results compared to PD (p = 0.018) and Placebo (p = 0.050), and similar result compared to MO+PD (p = 0.724). The sleep diary results and TAS results were not influenced by any of the treatments. No side effects were observed after treatments. CONCLUSION: MO showed promising results in the treatment of possible sleep bruxism in children, while the association of PD did not improve MO results.


Assuntos
Homeopatia , Melissa/química , Phytolacca/química , Extratos Vegetais/farmacologia , Bruxismo do Sono/tratamento farmacológico , Ansiedade/tratamento farmacológico , Criança , Pré-Escolar , Estudos Cross-Over , Feminino , Humanos , Masculino , Pais , Extratos Vegetais/química , Folhas de Planta/química , Caules de Planta/química , Autorrelato , Sono
18.
Regul Toxicol Pharmacol ; 103: 253-273, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30771368

RESUMO

The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use. Furthermore, this paper provides a multitude of data for selected raw materials processed in HMP with up to now rather scarce knowledge and, thus, aims at filling data gaps on acceptable amounts per day (AAD). The inclusion of raw materials into the compilation was determined considering the frequencies of their occurrence in HMP in Germany along with the availability of appropriate safety assessments. This safety evaluation compilation represents a practical, fairly comprehensive and systematic set of more than 170 raw materials. It is designed to both effectively support regulatory decision making and to be recognized and exploited by applicants, stakeholders and the scientific community.


Assuntos
Homeopatia/efeitos adversos , Materia Medica/efeitos adversos , Alemanha , Humanos , Medição de Risco
19.
Bull Cancer ; 106(3): 189-200, 2019 Mar.
Artigo em Francês | MEDLINE | ID: mdl-30771881

RESUMO

BACKGROUND: The use of complementary and alternative medicine (CAM) in children with cancer is commonly used. However, studies and data on this topic are still scarce in France. METHODS: Our aim was to investigate the prevalence of CAM usage in pediatric cancer patients and describe the modality of use. Our study population comprised children and young people treated from 2011 to 2012 in 2 French centers (Nantes, Paris). An anonymous self-administered questionnaire was addressed to families and data was collected from them and from the medical record. RESULTS: Out of the 202 patients selected for the study, 111 families answered the questionnaire (55%). Fifty-four (48.6%) of respondents reported CAM used. Forty-seven (87%) patients used CAM during initial therapy of cancer. Thirty-two (59.3%) of them talked about their CAM usage with health professionals, whose 25 (75.8%) with their oncologist. The three most common therapies used were homeopathy (75.8%), chiropractic (31.5%) and faith healing (42.6%). The main reason for the use of CAM was to control the side effects of conventional treatment (85.2%). Overall perceived satisfaction was rated 7.4/10. CONCLUSION: The prevalence of complementary and alternative medicines administration is high, even if scientific evidence is limited regarding the effects, mechanisms of action and security of CAM. Research is necessary to improve the communication and council quality to the family, optimize supportive cares and reinforce the pharmacovigilance.


Assuntos
Institutos de Câncer/estatística & dados numéricos , Terapias Complementares/estatística & dados numéricos , Neoplasias/terapia , Adolescente , Criança , Feminino , França , Pesquisas sobre Serviços de Saúde/estatística & dados numéricos , Homeopatia/estatística & dados numéricos , Humanos , Terapia de Campo Magnético/estatística & dados numéricos , Masculino , Manipulação Osteopática/estatística & dados numéricos , Neoplasias/mortalidade , Satisfação do Paciente
20.
Complement Ther Clin Pract ; 34: 165-173, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30712722

RESUMO

OBJECTIVE: Scientometrics is the evaluation of scientific literature in a certain field. Although popularity and use of homeopathy have increased in the recent years, scientific literature lacks a bibliometric or scientometric evaluation of homeopathy literature. METHODS: We collected all data of this study from four databases provided by Web of Science. All documents published between 1975 and 2017 were included. The keywords we searched for in detail were "homeopathy", "homeopathic", "homoeopathy" and "homoeopathic". We used Spearman's correlation test to investigate a possible correlation between publication numbers or the productivity and features of the countries. We created infographics and infomaps by using GunnMap and VOSviewer sources. Gross domestic product (GDP) ranking data of countries was procured from The World Data Bank. RESULTS: Our search retrieved a total of 4183 articles. The great majority of documents were original articles (n = 3043, 72.75%). The UK dominated homeopathy literature with 950 articles followed by the USA, Germany, India and Brazil (n = 636, 590, 277 and 246 items, respectively). Switzerland was found to be most productive country (20.41) followed by the UK, Norway and Israel (14.35, 11.31 and 8.41, respectively). University of Exeter (UK) was the leading institutions with 204 items (4.88%). Most productive journal was Homeopathy dominating and covering 24% of all literature. We detected very high correlation between publication number and citation number by year (r = 0.95, p < 0.001). A high correlation was measured between gross domestic product (GDP) per capita and productivity of the countries. A moderate correlation was measured between GDP and publication number of the countries (r = 0.66 and p < 0.001). In scientometric network analysis, the USA, the UK and Germany were noted to be three major association centers. CONCLUSIONS: We detected that developed countries dominated homeopathy literature and we suggest that physicians from least-developed and developing countries should be funded and encouraged to carry out homeopathy studies.


Assuntos
Homeopatia , Saúde Global , História do Século XX , História do Século XXI , Homeopatia/história , Homeopatia/estatística & dados numéricos , Humanos
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