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2.
Crim Behav Ment Health ; 30(2-3): 117-131, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32535969

RESUMO

BACKGROUND: Early puberty is associated with higher than average risk of antisocial behaviour, both in girls and boys. Most studies of such association, however, have focused on psychosocial mediating and moderating factors. Few refer to coterminous hormonal measures. AIM: The aim of this review is to consider the role of hormonal markers as potential mediating or moderating factors between puberty timing and antisocial behaviour. METHOD: A systematic literature search was conducted searching Medline, Embase, Web of Science, Scopus, Psycinfo, Cochrane and Google Scholar. RESULTS: Just eight studies were found to fit criteria, all cross-sectional. Measurements were too heterogeneous to allow meta-analysis. The most consistent associations found were between adrenal hormones-both androgens and cortisol-which were associated with early adrenarche and antisocial behaviours in girls and later adrenarche and antisocial behaviour in boys. CONCLUSIONS: The findings from our review suggest that longitudinal studies to test bidirectional hormone-behaviour associations with early or late puberty would be worthwhile. In view of the interactive processes between hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes, integrated consideration of the hormonal end products is recommended.


Assuntos
Comportamento do Adolescente/psicologia , Adrenarca/psicologia , Transtorno da Personalidade Antissocial/etiologia , Hormônios/sangue , Menarca/fisiologia , Puberdade/fisiologia , Maturidade Sexual/fisiologia , Adolescente , Comportamento do Adolescente/fisiologia , Adrenarca/fisiologia , Androgênios , Transtorno da Personalidade Antissocial/diagnóstico , Transtorno da Personalidade Antissocial/metabolismo , Criança , Feminino , Hormônios Esteroides Gonadais/sangue , Gonadotropinas Hipofisárias/sangue , Humanos , Hidrocortisona/metabolismo , Masculino , Fatores de Tempo
3.
PLoS One ; 15(4): e0223548, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32255792

RESUMO

This investigation examined anthropometric, hormonal, and physiological differences between advanced (ADV; n = 8, 27.8 ± 4.2 years, 170 ± 11 cm, 79.8 ± 13.3 kg) and recreational (REC; n = 8, 33.5 ± 8.1 years, 172 ± 14 cm, 76.3 ± 19.5 kg) CrossFit (CF) trained participants in comparison to physically-active controls (CON; n = 7, 27.5 ± 6.7 years, 171 ± 14 cm, 74.5 ± 14.3 kg). ADV and REC were distinguished by their past competitive success. REC and CON were resistance-trained (>2 years) and exercised on 3-5 days·wk-1 for the past year, but CON utilized traditional resistance and cardiovascular exercise. All participants provided a fasted, resting blood sample and completed assessments of resting metabolic rate, body composition, muscle morphology, isometric mid-thigh pull strength, peak aerobic capacity, and a 3-minute maximal cycle ergometer sprint across two separate occasions (separated by 3-7 days). Blood samples were analyzed for testosterone, cortisol, and insulin-like growth factor-1. Compared to both REC and CON, one-way analysis of variance revealed ADV to possess lower body fat percentage (6.7-8.3%, p = 0.007), greater bone and non-bone lean mass (12.5-26.8%, p ≤ 0.028), muscle morphology characteristics (14.2-59.9%, p < 0.05), isometric strength characteristics (15.4-41.8%, p < 0.05), peak aerobic capacity (18.8-19.1%, p = 0.002), and 3-minute cycling performance (15.4-51.1%, p ≤ 0.023). No differences were seen between REC and CON, or between all groups for resting metabolic rate or hormone concentrations. These data suggest ADV possess several physiological advantages over REC and CON, whereas similar physiological characteristics were present in individuals who have been regularly participating in either CF or resistance and cardiovascular training for the past year.


Assuntos
Atletas , Metabolismo Basal , Composição Corporal , Aptidão Cardiorrespiratória , Treinamento de Resistência/métodos , Adulto , Feminino , Estilo de Vida Saudável/fisiologia , Hormônios/sangue , Humanos , Contração Isométrica , Masculino , Treinamento de Resistência/efeitos adversos
4.
J Int Soc Sports Nutr ; 17(1): 13, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32131846

RESUMO

BACKGROUND: Low energy availability (LEA) is a medical condition observed in athletes, with a higher prevalence in aesthetic sports. For the first time, this study evaluated the relative prevalence of LEA in female elite athletes (ELA) and recreational athletes (REA) in aesthetic sports in China. METHODS: Female athletes from 6 sports (trampolining, rhythmic gymnastics, aerobics, dance sport, cheerleading and dance) were recruited, including ELA (n = 52; age = 20 ± 3) on Chinese national teams and REA (n = 114; Age = 20 ± 2) from Beijing Sport University. Participants completed 2 online questionnaires to assess LEA and eating disorder risk. These included the Low Energy Availability in Females Questionnaire (LEAF-Q), which provided information on injury history, gastrointestinal function and menstrual history, and the Eating Disorder Inventory-3 Referral Form (EDI-3 RF). For a sub-group of elite athletes (n = 14), body composition, bone mineral density, and blood serum were also quantified. RESULTS: A total of 41.6% of participants (n = 69) were at increased risk of LEA, and 57.2% of participants (n = 95) were classified as high in eating disorder risk. For ELA vs. REA, there was a significantly higher prevalence of LEA risk (55.8% vs. 35.1%; p = 0.012) and amenorrhea (53.8% vs. 13.3%; p < 0.001). Elite athletes at increased risk of LEA had significantly lower estradiol (p = 0.021) and whole-body BMD (p = 0.028). Pearson correlations indicated that the whole-body BMD (r = - 0.667, p = 0.009) correlated negatively with LEAF-Q score. CONCLUSIONS: Results of this study indicate that there is a risk of LEA in female Chinese athletes within aesthetic sports, and significantly higher prevalence of increased LEA risk observed in ELA than in REA. Chinese coaches and sports medicine staff working elite female athletes in aesthetic sports should develop strategies to reduce the prevalence of LEA.


Assuntos
Deficiência Energética Relativa no Esporte/epidemiologia , Fenômenos Fisiológicos da Nutrição Esportiva , Adolescente , Amenorreia , Grupo com Ancestrais do Continente Asiático , Atletas , Composição Corporal , Densidade Óssea , China , Estudos Transversais , Dança , Transtornos da Alimentação e da Ingestão de Alimentos , Feminino , Ginástica , Hormônios/sangue , Humanos , Prevalência , Fatores de Risco , Esportes , Inquéritos e Questionários , Adulto Jovem
5.
Poult Sci ; 99(2): 926-935, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32029169

RESUMO

The present study evaluated the effects of butyric acid supplementation and Saccharomyces boulardii (alone or in combination) on growth performance, nutrient digestibility, bone mineralization, and blood hormones of male broiler chickens fed a diet including reduced levels of nonphytate phosphorus (NPP). The chickens were allocated to 6 dietary treatments: 1) positive control diet with adequate amounts of NPP (PC; 0.48, 0.43, and 0.39% in the starter, grower, and finisher period, respectively); 2) negative control diet with low amounts of NPP (NC; 0.38, 0.33, and 0.29% in the starter, grower, and finisher period, respectively); 3) NC plus 500 FTU/kg microbial phytase (PHY); 4) NC plus 0.2% butyric acid (BA); 5) NC plus 1 × 108 cfu/kg S. boulardii (SB); 6) NC plus butyric acid and S. boulardii (BA+SB). Each treatment had 5 pen replicates of 25 birds. After 6 wk, the body weight and ADG in birds fed with any of the diets were higher (P < 0.001) than those in birds fed with the NC diet, where the birds fed with the PHY and BA+SB diets had the highest values. However, only the PHY diet improved (P = 0.041) overall F:G. All diets, except the SB diet, resulted in the increased apparent ileal digestibility coefficient (AIDC) of CP, AMEn, and tibia ash content and decreased serum alkaline phosphatase level compared with the NC diet (P < 0.05). Broiler chickens fed with the PHY, SB, and BA+SB diets also had increased AIDC of phosphorus (P = 0.017) than those fed with the NC and PC diets. Feeding PC, PHY, and BA+SB diets increased (P = 0.007) the tibia phosphorus content but decreased (P = 0.033) serum parathyroid hormone concentration. Overall, the present data indicate that the simultaneous inclusion of butyric acid plus S. boulardii in the low-NPP diets was beneficial for improving growth rate and bone mineralization, but not for feed efficiency.


Assuntos
Ácido Butírico/metabolismo , Calcificação Fisiológica/efeitos dos fármacos , Galinhas/fisiologia , Digestão/efeitos dos fármacos , Hormônios/sangue , Saccharomyces boulardii/química , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição Animal , Animais , Ácido Butírico/administração & dosagem , Cálcio/metabolismo , Galinhas/crescimento & desenvolvimento , Dieta/veterinária , Suplementos Nutricionais/análise , Relação Dose-Resposta a Droga , Nutrientes/metabolismo , Fósforo/deficiência , Fósforo/metabolismo , Probióticos/farmacologia , Distribuição Aleatória
6.
PLoS Biol ; 18(2): e3000629, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32097406

RESUMO

Human biology has evolved to keep body fat within a range that supports survival. During the last 25 years, obesity biologists have uncovered key aspects of physiology that prevent fat mass from becoming too low. In contrast, the mechanisms that counteract excessive adipose expansion are largely unknown. Evidence dating back to the 1950s suggests the existence of a blood-borne molecule that defends against weight gain. In this article, we discuss the research supporting an "unidentified factor of overfeeding" and models that explain its role in body weight control. If it exists, revealing the identity of this factor could end a long-lasting enigma of energy balance regulation and facilitate a much-needed breakthrough in the pharmacological treatment of obesity.


Assuntos
Depressores do Apetite/metabolismo , Peso Corporal/fisiologia , Hormônios/metabolismo , Tecido Adiposo/metabolismo , Animais , Depressores do Apetite/sangue , Hormônios/sangue , Humanos , Hiperfagia/genética , Hiperfagia/metabolismo , Obesidade/genética , Obesidade/metabolismo , Parabiose , Ganho de Peso/fisiologia
7.
Chemosphere ; 242: 125206, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31678849

RESUMO

Phthalates, a class of high production-volume chemicals widely used as plasticizers, have been shown to impair ovarian functions in female animals, but epidemiological evidence is very limited. In this case-control study, the associations between phthalate exposure and premature ovarian failure (POF) in women were assessed. A total of 173 POF cases and 246 control women were recruited in Zhejiang, China. The urinary concentrations of 8 phthalate metabolites and the serum levels of ovary-related hormones were determined. Mono-isobutyl phthalate (MiBP) was the metabolite with the highest median concentration of 27.23 µg/g of creatinine in the whole group. Compared with the lowest quartile, higher urinary concentrations of MiBP were significantly associated with increased odds of POF (OR = 1.38, 95% CI: 0.73-2.61 for the fourth quartile; p for trend = 0.01). The estradiol/FSH ratio, a marker of ovarian function, in control women was significantly negatively associated with the urinary concentrations of most tested phthalate metabolites. Our results suggest that exposure to some phthalates may impair ovarian function and increase the odds of POF in women.


Assuntos
Exposição Ambiental/efeitos adversos , Hormônios/sangue , Ácidos Ftálicos/metabolismo , Insuficiência Ovariana Primária/urina , Adulto , Biomarcadores/sangue , Estudos de Casos e Controles , China , Poluentes Ambientais/urina , Feminino , Hormônios/fisiologia , Humanos , Ácidos Ftálicos/urina , Plastificantes/efeitos adversos
8.
Arthritis Care Res (Hoboken) ; 72(2): 216-224, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31529686

RESUMO

OBJECTIVE: To estimate the incidence and analyze any cancer-associated factors in patients with systemic lupus erythematosus (SLE), differentiating between hormone-sensitive (HS) and non-HS cancers. METHODS: This was a retrospective multicenter study of a patient cohort from the Systemic Lupus Erythematosus Registry of the Spanish Society of Rheumatology. Included were the first cancer post-SLE diagnosis, clinical and sociodemographic information, cumulative damage, severity, comorbidities, treatments, and refractoriness. Cancers were classified as HS (prostate, breast, endometrium, and ovarian) and non-HS (the remainder). The standardized incidence ratio (SIR) was calculated and logistic regression models were built. RESULTS: A total of 3,539 patients (90.4% women) were included, 154 of whom had cancer (91% female), and 44 had HS cancer (100% female). The cancer SIR was 1.37 (95% confidence interval [95% CI] 1.15-1.59), with higher values in women age <65 years (SIR 2.38 [95% CI 1.84-2.91]). The SIR in women with HS versus non-HS cancer was 1.02 (95% CI 0.13-1.91) and 1.93 (95% CI 0.98-2.89). In HS versus non-HS cancers, SLE diagnostic age (odds ratio [OR] 1.04 [P = 0.002] versus 1.04 [P = 0.019]), and period of disease evolution (OR 1.01 [P < 0.001] versus 1.00 [P = 0.029]) were associated with cancer. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (OR 1.27 [P = 0.022]) and angiotensin-converting enzyme (ACE) inhibitor prescriptions (OR 2.87 [P = 0.048]) were associated with non-HS cancers. CONCLUSION: Cancer incidence in patients with SLE was higher than in the Spanish population, particularly among young women. This increase might be due to non-HS cancers, which would be associated with SLE involving greater cumulative damage where more ACE inhibitors are prescribed.


Assuntos
Hormônios/sangue , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/epidemiologia , Neoplasias/sangue , Neoplasias/epidemiologia , Adulto , Idoso , Estudos de Coortes , Feminino , Humanos , Estudos Longitudinais , Lúpus Eritematoso Sistêmico/diagnóstico , Masculino , Pessoa de Meia-Idade , Neoplasias/diagnóstico , Estudos Retrospectivos , Espanha/epidemiologia , Adulto Jovem
9.
J Strength Cond Res ; 34(1): 104-113, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30707143

RESUMO

Soria, M, Ansón, M, Lou-Bonafonte, JM, Andrés-Otero, MJ, Puente, JJ, and Escanero, J. Fat oxidation rate as a function of plasma lipid and hormone response in endurance athletes. J Strength Cond Res 34(1): 104-113, 2020-Plasma lipid changes during incremental exercise are not well known. The aim of this study was to investigate the relationship among fat oxidation rate, plasma lipids, and hormone concentrations in well-trained athletes. Twenty-six trained triathletes completed a graded cycle ergometer test to exhaustion increasing by 0.5 W·kg every 10 minutes. Fat oxidation rates were determined using indirect calorimetry. For each individual, maximal fat oxidation (MFO), the intensity at which MFO occurred (Fatmax), and the intensity at which fat oxidation became negligible (Fatmin) were determined. Blood samples for lipids and hormones analysis were collected at the end of each stage of the graded exercise test. All variables studied except insulin showed an increase at the end of incremental protocol with respect to basal levels. Free fatty acid reached significant increase at 60%VO2max and maximal levels at 70%VO2max. Low-density lipoprotein (LDL) and triglycerides (TG) decreased and showed lowest levels at 60%VO2max and reaching significant increases after 80%VO2max. High-density lipoprotein reached significant increase at 60%VO2max. Adrenaline and noradrenaline increased until the end of the incremental exercise, and significant differences were from 50%VO2max. These results suggest that exercise intensities are related to plasma lipids levels. In the zone when lipids oxidation is maximal, plasma LDL and TG variation differs from other lipids. These results may have application for the more adequate exercise intensity prescription to maximize the beneficial effects of exercise.


Assuntos
Tecido Adiposo/metabolismo , Hormônios/sangue , Metabolismo dos Lipídeos , Lipídeos/sangue , Resistência Física , Adulto , Atletas , Calorimetria Indireta , Catecolaminas/sangue , Ergometria , Exercício Físico/fisiologia , Teste de Esforço , Ácidos Graxos não Esterificados/sangue , Humanos , Insulina/sangue , Masculino , Oxirredução , Consumo de Oxigênio
10.
J Ethnopharmacol ; 248: 112300, 2020 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-31606536

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Mahuang-Tang (MHT) has traditionally been used in Asia to treat a variety of diseases, such as fever without sweating, joint pain, lower back pain, asthma, and gynecological conditions. Polycystic ovary syndrome (PCOS) is a kind of gynecological disease that causes amenorrhea, infertility, and menopausal and urogenital disorders that could benefit from MHT treatment. AIM OF THE STUDY: In this study, we examined the effects of MHT on ovarian hormones and steroidogenic enzymes in female PCOS rats. METHODS AND RESULTS: The PCOS rat model was induced by Letrozole, and an in vivo evaluation of whether the dietary consumption of MHT improved the PCOS-like symptoms was conducted. The luteinizing hormone (LH) level and luteinizing hormone/follicular-stimulating hormone (LH/FSH) ratio increased in PCOS rats but decreased following MHT treatment. In the PCOS rats, the reduced estrogen level was restored to that of normal controls with MHT treatment in serum. The transcription level(s) of gonadotropin receptors (Fshr and Lhr), steroid receptors (Pgr, and Esr1) and steroidogenic enzymes (Cyp19a1, Hsd3b1, Hsd17a1, and Cyp11a1) changed under the PCOS condition, and were regulated by MHT treatment in the ovaries of PCOS rats. The reproductive tissues of Letrozole-induced PCOS rats were restored into estrogenic condition from androgen environments. CONCLUSION: These results suggest that MHT ameliorates the symptoms of PCOS by improving the dysregulation of ovarian steroids and steroidogenic enzymes in PCOS rats.


Assuntos
Medicina Tradicional Coreana , Síndrome do Ovário Policístico/tratamento farmacológico , Animais , Feminino , Hormônios/sangue , Letrozol , Medicina Tradicional , Ovário/efeitos dos fármacos , Ovário/metabolismo , Ovário/patologia , Síndrome do Ovário Policístico/induzido quimicamente , Síndrome do Ovário Policístico/genética , Síndrome do Ovário Policístico/patologia , Ratos Sprague-Dawley , Receptores da Gonadotropina/genética , Receptores de Esteroides/genética , Esteroide Hidroxilases/genética
11.
BMC Genomics ; 20(1): 1013, 2019 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-31870281

RESUMO

BACKGROUND: As a newly characterized type of noncoding RNA, circular RNA (circRNA) has been shown to have functions in diverse biological processes of animals. It has been reported that several noncoding RNAs may regulate animals' response to heat stress which can be easily induced by hyperthermia in summer. However, the expression and functions of circRNAs in the pituitary of sows and whether they participate in heat stress adaption are still unclear. RESULTS: In this study, we found that high temperature over the thermoneutral zone of sows during the summer increased the serum heat shock protein 70 (HSP70) level, decreased the superoxide dismutase (SOD) vitality and prolactin (PRL) concentration, and induced heat stress in sows. Then, we explored circRNA in the pituitary of heat-stressed and normal sows using RNA sequencing and bioinformatics analysis. In total, 12,035 circRNAs were detected, with 59 circRNAs differentially expressed, including 42 up-regulated and 17 down-regulated circRNAs in pituitaries of the heat-stressed sows. Six randomly selected circRNAs were identified through reverse transcription PCR followed by DNA sequencing and other 7 randomly selected differentially expressed circRNAs were verified by quantitative real-time PCR analysis. The predicted target genes regulated by circRNAs through sponging microRNAs (miRNAs) were enriched in metabolic pathway. Furthermore, the predicted circRNA-miRNA-mRNA interactions showed that some circRNAs might sponge miRNAs to regulate pituitary-specific genes and heat shock protein family members, indicating circRNA's roles in pituitary hormone secretion and heat stress response. CONCLUSIONS: Our results provided a meaningful reference to understand the functions of circRNA in the porcine pituitary and the mechanisms by which circRNA may participate in animals' response to heat stress.


Assuntos
Genômica , Resposta ao Choque Térmico/genética , Hipófise/metabolismo , RNA Circular/genética , Animais , Antioxidantes/metabolismo , Sequência de Bases , Redes Reguladoras de Genes , Hormônios/sangue , Hipófise/fisiologia , Suínos
12.
J Ovarian Res ; 12(1): 109, 2019 Nov 13.
Artigo em Inglês | MEDLINE | ID: mdl-31722718

RESUMO

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder and regarded as the leading cause of anovulatory infertility. PCOS is characterized by reproductive dysfunction and metabolic disorders. Baicalin (BAL) is one of the most potent bioactive flavonoids isolated from the radix of Scutellaria baicalensis. In the present study, we investigated the potential effects of BAL on PCOS in dehydroepiandrosterone-treated rats. We found that BAL notably reduced the serum levels of free testosterone, total testosterone, follicle-stimulating hormone, luteinizing hormone, progesterone, and estradiol in PCOS rats. The increase of serum insulin level and HOMA-IR was markedly inhibited by BAL. Moreover, BAL decreased body weights, increased the number of rats with the regular estrous cycle, and ameliorated ovarian histological changes and follicular development in the DHEA-treated PCOS rats. The increase of pro-inflammatory cytokines (TNFα, IL-1ß, and IL-18) and decrease of anti-inflammatory cytokine (IL-10) in PCOS rats were suppressed by BAL. BAL induced a significant decrease in the mRNA expression of steroidogenic enzymes, including 3ß-HSD, CYP11A1, CYP19A1, StAR, in ovarian tissues in PCOS rats. Furthermore, BAL inhibited the decrease of AMPK protein level and phosphorylation, the decrease of Akt phosphorylation and the increase of 5α-reductase enzyme 1 expression in ovarian tissues in PCOS rats. The effects of BAL were inhibited by an inhibitor of AMPK, dorsomorphin. The upregulation of AMPK contributed to the beneficial effects of BAL. The results highlight the potential role of BAL for the intervention of PCOS.


Assuntos
Proteínas Quinases Ativadas por AMP/metabolismo , Anti-Inflamatórios/uso terapêutico , Flavonoides/uso terapêutico , Síndrome do Ovário Policístico/tratamento farmacológico , Animais , Anti-Inflamatórios/farmacologia , Peso Corporal/efeitos dos fármacos , Citocinas/metabolismo , Feminino , Flavonoides/farmacologia , Hormônios/sangue , Resistência à Insulina , Ovário/efeitos dos fármacos , Ovário/metabolismo , Ovário/patologia , Síndrome do Ovário Policístico/sangue , Síndrome do Ovário Policístico/metabolismo , Ratos Wistar
13.
Artigo em Inglês | MEDLINE | ID: mdl-31671514

RESUMO

Aging causes a decline in physical function and hormonal balance. Exercise can improve these parameters. However, the beneficial effects of a combined exercise program (Korean dance and yoga) on physical function and hormonal status in elderly women remain unknown. This study aims to investigate the effects of a 12-week combined exercise program on balance, flexibility, muscle strength, and hormonal status in elderly Korean women. Twenty-five healthy elderly women were recruited and randomly divided into the control (CON) and exercise (EXE) groups. The EXE group underwent the combined exercise program (60 min/day and 3 times/week) for 12 weeks. The two groups did not differ in body weight, lean body mass, fat mass, body fat percentage, or body mass index at baseline or in the changes following the experimental conditions. A significant time × group interaction was detected for anterior and posterior dynamic balance, static balance, and growth hormone (GH). After the combined exercise program, anterior dynamic balance, posterior dynamic balance, static balance, flexibility, muscle strength, GH, dehydroepiandrosterone-sulfate, and estrogen significantly increased in the EXE group compared to the CON group. In conclusion, the combined exercise program contributed to improvements in overall health, including physical function and hormonal status, in elderly Korean women.


Assuntos
Envelhecimento/fisiologia , Dança/fisiologia , Exercício Físico/fisiologia , Hormônios/sangue , Força Muscular/fisiologia , Equilíbrio Postural/fisiologia , Ioga , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Composição Corporal/fisiologia , Sulfato de Desidroepiandrosterona/sangue , Estrogênios/sangue , Feminino , Seguimentos , Nível de Saúde , Hormônio do Crescimento Humano/sangue , Humanos , Avaliação de Resultados em Cuidados de Saúde , Amplitude de Movimento Articular/fisiologia , República da Coreia , Saúde da Mulher
14.
Georgian Med News ; (294): 27-31, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31687944

RESUMO

The aim of the research is to study the dynamics of functional capabilities of 17-22 year old girls with different vegetative status during the ovarian-menstrual cycle. By the use of questionnaires and anthropo-physiometry, 28 girls with low motor activity and a regular (more than 3 cycles) menstrual cycle were selected, which allowed to determine the phases by calendar method. All of the surveyed people were in the main medical group of health. The modernized method of D. N. Davidenko muscular load was used. The heart rate was recorded at rest when the heart rate was reached at 150-155 beats per minute, at the end of testing and on the 5th minute of recovery, sitting on the cycle ergometer. To estimate the variability of the heart rate, a number of indicators proposed by R. M. Bayevsky were calculated to characterize the state of the vegetative nervous system. The degree of centralization of heart rate control was determined by means of a stress index, on the basis of which the group of patients was divided into subgroups depending on the type of regulation in the state of relative rest in the first (menstrual) phase of the menstrual cycle. It has been identified that vagotonics are characterized by higher, and sympathicotonics - by low values of PWC170, as an integral indicator of the body's functional capabilities. The optimal phases of physical performance for girls with vagotonic type of regulation are menstrual and premenstrual, with normotonic - menstrual and ovulatory, with sympathicotonic - postmenstrual and postovulatory phases of OMC. Physical activity in other phases of the cycle increases the level of functional stress and can provoke pre-pathological and pathological conditions.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Exercício Físico/fisiologia , Frequência Cardíaca/fisiologia , Hormônios/sangue , Ciclo Menstrual/fisiologia , Ovário/fisiologia , Adolescente , Feminino , Humanos , Adulto Jovem
15.
Presse Med ; 48(12): 1445-1455, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31761607

RESUMO

The Hormonal assessment of Arterial Hypertension (HTA) is an important part of the balance of resistant hypertension. This assessment - going well beyond the search for primary hyperaldosteronism (PHA) - requires a rigorous methodology and a robust experience of the nursing team within a dedicated unit: the HTA Day Hospital. If all the conditions are met and the assessment carried out well, it will allow a significant profitability since in this resistant hypertensive population it will detect a particular mechanism or secondary hypertension in 70% of patients. Since the diagnosis of PHA is essentially biological, the proper execution of the various stages of the assessment is essential to its documentation.


Assuntos
Técnicas de Diagnóstico Endócrino , Hormônios/análise , Hipertensão/diagnóstico , Aldosterona/análise , Aldosterona/sangue , Anti-Hipertensivos/uso terapêutico , Análise Química do Sangue/métodos , Análise Química do Sangue/normas , Diagnóstico Diferencial , Técnicas de Diagnóstico Endócrino/normas , Resistência a Medicamentos/efeitos dos fármacos , Hormônios/sangue , Humanos , Hiperaldosteronismo/diagnóstico , Hipertensão/sangue , Hipertensão/tratamento farmacológico , Hipertensão/etiologia , Renina/análise , Renina/sangue
16.
Mol Biol Rep ; 46(5): 4675-4684, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31529342

RESUMO

The purpose of this study was to test the hypothesis that different cytokine profiles may exist in the follicular fluid of endometriosis (EM) patients undergoing in vitro fertilization (IVF), as these differences may provide insights into the pathogenesis of the disease. This was a cross-sectional study conducted at the reproductive center of a medical university hospital. The study included 49 patients receiving IVF. 20 infertile women with proven EM and 29 women without diagnosed EM (control group) were evaluated. Follicular fluid (FF) and serum were collected at the time of follicle aspiration and the concentrations of 38 cytokines were determined by multiplexed immunoassay. The results indicated that the levels of IL-4, IL-13, IL-3 and IL-1α were significantly increased in the FF of women with EM, while levels of IFN-γ, IL-17A, MDC and MIP-1α were decreased compared with in the control subjects. In conclusions, the immune microenvironment of the FF in patients with EM is altered. This may contribute to the pathologic mechanism responsible for the poor outcome of IVF in patients with EM.


Assuntos
Microambiente Celular/imunologia , Endometriose/diagnóstico , Endometriose/etiologia , Folículo Ovariano/imunologia , Biomarcadores , Citocinas/biossíntese , Citocinas/sangue , Endometriose/metabolismo , Feminino , Fertilização In Vitro/efeitos adversos , Líquido Folicular/imunologia , Líquido Folicular/metabolismo , Hormônios/sangue , Hormônios/metabolismo , Humanos , Folículo Ovariano/metabolismo , Folículo Ovariano/patologia
17.
Eur J Endocrinol ; 181(5): 481-488, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31505456

RESUMO

Background: HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. Methods: In a cross-sectional study of CAH patients matched on sex and age with healthy control, the association between circulating levels of soluble HLA-G and hormones was assessed by use of non-parametric analyses tests. Multivariable linear regressions were performed on normalized data. Results: Overall, 83 CAH patients and 69 healthy controls were included. Among CAH patients, all were under glucocorticoid and 52 (62.6%) were under mineralocorticoid supplementation. Compared to controls, CAH patients had increased HLA-G levels (15 vs 8 ng/mL, P = 0.02). In controls, HLA-G level was independently associated with progesterone and estradiol (ß = 0.44 (0.35-1.27) and -0.44 (-0.94, -0.26) respectively, both P values = 0.001). In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (ß = 0.25 (0.04-0.41), P = 0.001) and estradiol (ß = -0.22 (-0.57, -0.02), P < 0.001). Conclusion: CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.


Assuntos
Hiperplasia Suprarrenal Congênita/metabolismo , Antígenos HLA-G/sangue , Hormônios/sangue , Corticosteroides/uso terapêutico , Hiperplasia Suprarrenal Congênita/tratamento farmacológico , Adulto , Biomarcadores/sangue , Estudos Transversais , Estradiol/uso terapêutico , Feminino , Humanos , Masculino , Mineralocorticoides/sangue , Progesterona/uso terapêutico , Renina/sangue , Adulto Jovem
18.
Artigo em Inglês | MEDLINE | ID: mdl-31505823

RESUMO

The impact of psychosocial factors on health has received increased attention. This study employed a multi-stage hierarchical cluster sampling method and a cross-sectional survey was conducted from March to August 2017. By studying 2116 oilfield workers based in Karamay, Xinjiang, the relationship between occupational stress, blood hormone levels, and sleep was analyzed. Occupational stress was measured using the internationally accepted Occupational Stress Inventory Revised Edition (OSI-R) questionnaire and sleep disorders were measured using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The study found that the sleep quality of respondents was not high and the incidence of sleep disorders was 36.67%. The higher the level of occupational stress, the higher the incidence of sleep disorders. Irregular shifts can affect sleep quality and individuals with high-level professional titles experience a higher incidence of sleep disorders than those with low-level titles. The total score of the PSQI was different among the low, medium, and high stress groups. The higher the level of stress, the higher the scores of subjective sleep quality, sleep disorder, and daytime dysfunction. The scores of the PSQI, subjective sleep quality, sleep time, sleep disturbance, and daytime dysfunction in the high-stress group were higher than those in the low stress group. A case-control study found that the concentration of glucocorticoids in the sleep disorder positive group was lower than that in the sleep disorder negative group. The results of the regression analysis showed that glucocorticoid is a protective factor for sleep disorders (OR = 0.989, 95% CI: 0.983-0.995), suggesting that the higher the level of glycosaminoglycan, the less likely the subject is to have sleep disorders. For example, in the case of high occupational stress, the interaction between low and moderate occupational stress levels and glucocorticoids is a protective factor for sleep disorders.


Assuntos
Hormônios/sangue , Estresse Ocupacional/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Sono , Adulto , Estudos de Casos e Controles , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estresse Ocupacional/complicações , Campos de Petróleo e Gás , Transtornos do Sono-Vigília/etiologia , Adulto Jovem
19.
Cir Cir ; 87(S1): 62-67, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31501633

RESUMO

Background: Primary hyperparathyroidism (PHPT) is characterized by an increase in parathyroid hormone (PTH) and hypercalcemia, which, when present during pregnancy, increases both maternal and fetal morbidity and mortality. Objective: Emphasize the importance of surgical intervention in primary hyperparathyroidism during pregnancy. Clinical case: A 27-year-old female with a pregnancy of 27.2 weeks of gestation, with a diagnosis of symptomatic primary hyperparathyroidism secondary to parathyroid adenoma, a history of nephrolithiasis and severe acute pancreatitis, surgery was decided upon finding intrathyroid right parathyroid adenoma, post-surgical course with adequate evolution and remission of hyperparathyroidism. Conclusions: Parathyroidectomy in primary hyperparathyroidism during pregnancy is safe.


Assuntos
Adenoma/complicações , Hiperparatireoidismo Primário/etiologia , Neoplasias das Paratireoides/complicações , Paratireoidectomia , Complicações Neoplásicas na Gravidez/cirurgia , Doença Aguda , Adenoma/diagnóstico , Adenoma/cirurgia , Adulto , Transfusão de Componentes Sanguíneos , Cálcio/metabolismo , Carcinoma Papilar/diagnóstico , Carcinoma Papilar/cirurgia , Feminino , Hormônios/sangue , Humanos , Hipercalcemia/etiologia , Hiperparatireoidismo Primário/sangue , Achados Incidentais , Nefrolitíase/etiologia , Pancreatite/etiologia , Neoplasias das Paratireoides/diagnóstico , Neoplasias das Paratireoides/cirurgia , Gravidez , Complicações Neoplásicas na Gravidez/sangue , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia
20.
Int J Biol Macromol ; 140: 1098-1105, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31449864

RESUMO

In order to investigate prevention of squid ink polysaccharide (SIP) against cyclophosphamide (CP) induced ovarian failure and immunosuppression in mice, female Kunming mice were subjected to intraperitoneal injection of CP (120 mg/kg) and oral administration of SIP (50, 65, 80 and 110 mg/kg, continuous 14 days). At the end of the experiment, animals were sacrificed to collect sera, spleens, thymuses and ovaries for determining relative masses of organs, serum hormonal levels, contents of interleukin 2 (IL-2) and tumor necrosis factor α (TNF-α) in ovary and serum, superoxide dismutase (SOD) activity and malonaldehyde (MDA) content in ovary, contents of nuclear factor E2 related factor 2 (Nrf2) signaling pathway-related proteins in ovary, and peripheral blood populations of CD4+, CD8+ and natural killer (NK) cells. Results showed that CP induced immunosuppression in mice which was demonstrated by decreased relative masses of spleen and thymus, contents of IL-2 and TNF-α, ratio of CD4+ / CD8+, and increased population of NK cells. But the suppressive action was disinhibited by SIP. Meanwhile, CP treatment caused dysfunction of ovaries in mice that could be concluded by decreased relative mass of ovary, disruption of redox equilibrium, and modified contents of Nrf2 signaling pathway-related proteins. However, SIP exposure rescued the negative effect CP mediated in ovaries of mice. These data can be concluded that SIP protects mice from CP inducing immunosuppression and ovarian failure via Nrf2/ARE (antioxidant response element) signaling pathway.


Assuntos
Ciclofosfamida/efeitos adversos , Imunossupressão , Tinta , Ovário/patologia , Polissacarídeos/farmacologia , Sepia/química , Animais , Peso Corporal/efeitos dos fármacos , Feminino , Hormônios/sangue , Interleucina-2/sangue , Linfócitos/efeitos dos fármacos , Linfócitos/metabolismo , Camundongos , Tamanho do Órgão/efeitos dos fármacos , Ovário/efeitos dos fármacos , Oxirredução , Transdução de Sinais/efeitos dos fármacos , Baço/efeitos dos fármacos , Baço/patologia , Timo/efeitos dos fármacos , Timo/patologia , Fator de Necrose Tumoral alfa/sangue
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