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1.
Int J Med Sci ; 18(3): 646-651, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33437199

RESUMO

Objectives: A significant proportion of discharged COVID-19 patients still have some symptoms. Traditional Chinese medicine (TCM) has played an important role in the treatment of COVID-19, but whether it is helpful for discharged patients is still unknown. The aim of this study was to retrospectively analyze the impacts of TCM treatment on the convalescents of COVID-19. Methods: A total of 372 COVID-19 convalescents from February 21 to May 3 in Shenzhen, China were retrospectively analyzed, 291 of them accepted clinically examined at least once and 191 convalescents accepted TCM. Results: After retrospective analysis of the clinical data of convalescents accepted TCM treatment or not, we found that the white blood cell count, as well as serum interleukin-6 and procalcitonin decreased in TCM group. Serum γ-glutamyl transpeptidase was significantly decreased, while prealbumin and albumin increased in TCM group. Red blood cell, hemoglobin, and platelet count increased in TCM group. The mechanisms of TCM treatment might be the overall regulations, including balanced immune response, improved hematopoiesis and coagulation systems, enhanced functions of liver and heart, increased nutrient intake and lipid metabolism. Conclusions: This study suggested that TCM treatment would be beneficial for discharged COVID-19 patients. However, long-term medical observation and further study with randomized trial should be done to confirm this result. Besides, the potential molecular mechanisms of TCM treatment should be further revealed.


Assuntos
/reabilitação , Convalescença , Medicamentos de Ervas Chinesas/administração & dosagem , /sangue , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Estudos Retrospectivos , Resultado do Tratamento
3.
Curationis ; 43(1): e1-e8, 2020 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-32242423

RESUMO

BACKGROUND: To prevent the spread of infection of tuberculosis (TB), sufficient knowledge and safe practices regarding occupational exposure are crucial for all employees working in TB hospitals. OBJECTIVES: To explore and describe the knowledge and practices of employees working in three specialised TB hospitals in Nelson Mandela Bay, Eastern Cape, regarding occupational exposure to TB. METHODS: A quantitative, descriptive and contextual study was conducted using convenience sampling to have 181 employees at the three hospitals elected to complete the self-administered questionnaire, which was distributed in December 2016. Three scores on a scale of 0-10 were calculated per participant: knowledge, personal practice and institutional practice. Descriptive and inferential statistics were utilised. RESULTS: Approximately, one-third (34%) of the participants were between the ages of 36 and 45 years. Most of the participants (63%) attended high school and less than one-third (28%) had a tertiary qualification. The majority of participants (62%) had not received any clinical training. Participants displayed high scores ( 6) for knowledge (75%; mean = 6.65), personal practice (68%; mean = 6.12) and institutional practice (51%; mean = 6.15). The correlation between knowledge and personal practice was found to be non-significant (r = 0.033). An analysis of variance revealed that Knowledge is significantly related to age and education level. CONCLUSION: Employees' knowledge regarding occupational TB exposure was generally high, but they were not necessarily practicing what they knew. Further research is required regarding appropriate managerial interventions to ensure that employees' practices improve, which should reduce the risk of occupational TB exposure.


Assuntos
Exposição Ocupacional/efeitos adversos , Tuberculose/enfermagem , Adulto , Análise de Variância , Atitude do Pessoal de Saúde , Feminino , Hospitais de Isolamento/organização & administração , Hospitais de Isolamento/normas , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Exposição Ocupacional/prevenção & controle , África do Sul , Inquéritos e Questionários
6.
Ann Ital Chir ; 91: 563-567, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33554942

RESUMO

2019-nCoV currently named SARS-CoV-2 is a highly pathogenic Coronavirus identified in Wuhan China in December 2019. Turkey declared the first case relatively late compared to Asian and European countries on March 11, as the first SARS-CoV-2 infection in Turkey. In this study, we aimed to determine patients' outcomes in 50 surgeries done in the incubation period of SARS-CoV-2 in our hospital. METHODS: We retrospectively analyzed the clinical data of 50 patients who underwent surgeries during the incubation period of CoVid-19 at Istinye University Gaziosmanpasa Medical Park Hospital in Istanbul, from March 2 to April 11, 2020. RESULTS: The age of 50 patients range was 21 to 73, and the median age was 43.32 (64%) patients were women. The median length of hospital stay is 2.6 days (1-21). Operations at various difficulty levels were also performed on patients with co-morbidities. No complication or mortality was observed except for 1 patient, and the ICU requirement of that patient was also due to high energy trauma. CONCLUSION: Although contrary claims have been made in various studies; it is the primary duty of us surgeons to operate CoVid-19 positive/suspicious patients safely and without any contamination, and on the other hand, to continue their operations without victimizing negative patients. In this pilot study, we would like to emphasize with necessary and adequate measures these can be achieved. KEY WORDS: CoVid-19, SARS-CoV-2, Surgery.


Assuntos
/diagnóstico , Emergências/epidemiologia , Hospitais de Isolamento/estatística & dados numéricos , Hospitais Universitários/estatística & dados numéricos , Período de Incubação de Doenças Infecciosas , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Pandemias , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Adulto , Idoso , /epidemiologia , Comorbidade , Procedimentos Cirúrgicos Eletivos/mortalidade , Procedimentos Cirúrgicos Eletivos/estatística & dados numéricos , Contaminação de Equipamentos/prevenção & controle , Feminino , Mortalidade Hospitalar , Humanos , Controle de Infecções/métodos , Masculino , Pessoa de Meia-Idade , Isolamento de Pacientes , Projetos Piloto , Estudos Retrospectivos , Procedimentos Cirúrgicos Operatórios/mortalidade , Tomografia Computadorizada por Raios X , Turquia/epidemiologia , Adulto Jovem
7.
Clin Microbiol Infect ; 21S: e1-e5, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24750421

RESUMO

Highly infectious diseases (HIDs) are defined as being transmissible from person to person, causing life-threatening illnesses and presenting a serious public health hazard. In most European Union member states specialized isolation facilities are responsible for the management of such cases. Ground ambulances are often affiliated with those facilities because rapid relocation of patients is most desirable. To date, no pooled data on the accessibility, technical specifications and operational procedures for such transport capacities are available. During 2009, the 'European Network for HIDs' conducted a cross-sectional analysis of hospitals responsible for HID patients in Europe including an assessment of (a) legal aspects; (b) technical and infrastructure aspects; and (c) operational procedures for ground ambulances used for HID transport. Overall, 48 isolation facilities in 16 European countries were evaluated and feedback rates ranged from 78% to 100% (n = 37 to n = 48 centres). Only 46.8% (22/47) of all centres have both national and local guidelines regulating HID patient transport. If recommended, specific equipment is found in 90% of centres (9/10), but standard ambulances in only 6/13 centres (46%). Exclusive entrances (32/45; 71%) and pathways (30/44; 68.2%) for patient admission, as well as protocols for disinfection of ambulances (34/47; 72.3%) and equipment (30/43; 69.8%) exist in most centres. In conclusion, the availability and technical specifications of ambulances broadly differ, reflecting different preparedness levels within the European Union. Hence, regulations for technical specifications and operational procedures should be harmonized to promote patient and healthcare worker safety.


Assuntos
Doenças Transmissíveis/terapia , Hospitais de Isolamento/estatística & dados numéricos , Controle de Infecções/normas , Isolamento de Pacientes/normas , Transporte de Pacientes/estatística & dados numéricos , Ambulâncias/normas , Ambulâncias/provisão & distribução , Estudos Transversais , Desinfecção , Europa (Continente) , Pesquisas sobre Serviços de Saúde , Hospitais de Isolamento/legislação & jurisprudência , Hospitais de Isolamento/normas , Humanos , Controle de Infecções/legislação & jurisprudência , Controle de Infecções/organização & administração , Isolamento de Pacientes/instrumentação , Isolamento de Pacientes/legislação & jurisprudência , Transporte de Pacientes/legislação & jurisprudência , Transporte de Pacientes/normas
8.
Infect Control Hosp Epidemiol ; 37(3): 313-8, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26641267

RESUMO

OBJECTIVE: To describe current Ebola treatment center (ETC) locations, their capacity to care for Ebola virus disease patients, and infection control infrastructure features. DESIGN: A 19-question survey was distributed electronically in April 2015. Responses were collected via email by June 2015 and analyzed in an electronic spreadsheet. SETTING: The survey was sent to and completed by site representatives of each ETC. PARTICIPANTS: The survey was sent to all 55 ETCs; 47 (85%) responded. RESULTS: Of the 47 responding ETCs, there are 84 isolation beds available for adults and 91 for children; of these pediatric beds, 35 (38%) are in children's hospitals. In total, the simultaneous capacity of the 47 reporting ETCs is 121 beds. On the basis of the current US census, there are 0.38 beds per million population. Most ETCs have negative pressure isolation rooms, anterooms, and a process for category A waste sterilization, although only 11 facilities (23%) have the capability to sterilize infectious waste on site. CONCLUSIONS: Facilities developed ETCs on the basis of Centers for Disease Control and Prevention guidance, but specific capabilities are not mandated at this present time. Owing to the complex and costly nature of Ebola virus disease treatment and variability in capabilities from facility to facility, in conjunction with the lack of regulations, nationwide capacity in specialized facilities is limited. Further assessments should determine whether ETCs can adapt to safely manage other highly infectious disease threats.


Assuntos
Doença pelo Vírus Ebola/terapia , Número de Leitos em Hospital/estatística & dados numéricos , Hospitais de Isolamento/estatística & dados numéricos , Hospitais Pediátricos/estatística & dados numéricos , Controle de Infecções/normas , Centers for Disease Control and Prevention, U.S. , Humanos , Inquéritos e Questionários , Estados Unidos
10.
Ethiop Med J ; Suppl 1: 37-41, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24696987

RESUMO

BACKGROUND: Cutaneous leishmaniasis is endemic to many parts of the world and has re-emerged in a number of endemic countries in recent years. Environmental changes, immune status of the host and treatment failure are the three most important risk factors associated with the re-emerging and spread of Leishmaniasis. Cutaneous leishmaniasis (CL) ranges from localized, self-healing type to the disfiguring mucocutaneous and diffuse cutaneous type. OBJECTIVE: To access the trend of CL patient flow in ALERT Hospital, Addis Ababa, Ethiopia. METHODS: Patients' clinical and laboratory records were collected retrospectively for 1651 leishmaniasis suspected individuals from ALERT Hospital, from January 1, 2007 to December 30, 2010. RESULTS: From the suspected individuals, 234 cases were positive for Leishmania species with Giemsa stain and/or histopathology and confirmed for CL, of whom 30 (12.8%) were diagnosed in 2007, 29 (12.4%) in 2008, 75 (32.1%) in 2009, and 100 (42.7%) were in 2010. CONCLUSIONS AND RECOMMENDATIONS: The overall proportion of cases with leishmaniasis among the suspected cases was 234/1651 (14.2%). The distribution of CL reports was higher for patients coming from Addis Ababa surrounding areas and Oromia region, 96/234 (41.03%) and 71/234 (30.34%), respectively. In general, the trend of leishmaniasis in and around Addis Ababa seems to be increasing, which calls for further detailed epidemiological studies, including vector and reservoir host studies, to help in the prevention and control of the disease.


Assuntos
Leishmania , Leishmaniose Cutânea/diagnóstico , Leishmaniose Cutânea/epidemiologia , Adulto , Idoso , Criança , Pré-Escolar , Etiópia/epidemiologia , Feminino , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Lactente , Leishmania/classificação , Leishmania/isolamento & purificação , Leishmaniose Cutânea/parasitologia , Leishmaniose Cutânea/prevenção & controle , Leishmaniose Cutânea/transmissão , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco
11.
Rev Med Chir Soc Med Nat Iasi ; 117(2): 476-82, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24340533

RESUMO

UNLABELLED: Given its epidemic potential and development of severe forms of disease, viral meningitis (VM) is a serious public health problem. AIM: to characterize the main clinical, epidemiologic features, the etiology and treatment of VM cases admitted to the Iasi Infectious Diseases Hospital, in 2012. MATERIAL AND METHODS: We retrospectively analyzed the medical records of the patients admitted for viral meningitis at the Iasi "St. Parascheva" Infectious Diseases Hospital in the interval January 1- December 31, 2012 (98 cases). The etiologic diagnosis was made by determining the IgM/IgG antibodies against Coxsackie virus and/or West Nile virus in blood/CSF. RESULTS: There was a fourfold increase in the number of cases as compared to the average for the years 2009-2011. Most cases (73.5%) were children aged 1 to 14 years. 61.8% of patients were males, 51.7% from urban areas. The most common symptom was headache (85.7%), followed by fever (77.6%), and vomiting (66.3%). Neck stiffness was absent in 28.6% cases. In43.5% of the 39 patients serologically investigated a Coxsackie virus infection was confirmed and 1/20 was positive for West Nile virus; three varicella-zoster virus infections and one mumps infection were diagnosed clinically. 68.3% of the patients received first-line antibiotic treatment. CONCLUSIONS: The illness mainly affected children, fever and neck stiffness being sometimes absent. The etiology was known in 22.4% of cases; enter viruses being the most frequent causative agent. Most patients received antibiotic therapy. The course was favorable in all cases.


Assuntos
Meningite Viral/diagnóstico , Meningite Viral/epidemiologia , Admissão do Paciente/estatística & dados numéricos , Adolescente , Adulto , Criança , Pré-Escolar , Diagnóstico Diferencial , Enterovirus/isolamento & purificação , Feminino , Febre/virologia , Cefaleia/virologia , Hospitais de Isolamento/estatística & dados numéricos , Hospitais Universitários , Humanos , Lactente , Masculino , Meningite Viral/complicações , Meningite Viral/terapia , Meningite Viral/virologia , Prevalência , Estudos Retrospectivos , Fatores de Risco , Romênia/epidemiologia , Vômito/virologia , Vírus do Nilo Ocidental/isolamento & purificação
12.
Arch Intern Med ; 170(14): 1228-38, 2010 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-20660842

RESUMO

BACKGROUND: The role of exposure to specific antiretroviral drugs on risk of myocardial infarction in human immunodeficiency virus (HIV)-infected patients is debated in the literature. METHODS: To assess whether we confirmed the association between exposure to abacavir and risk of myocardial infarction (MI) and to estimate the impact of exposure to other nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs), and non-NRTIs on risk of MI, we conducted a case-control study nested within the French Hospital Database on HIV. Cases (n = 289) were patients who, between January 2000 and December 2006, had a prospectively recorded first definite or probable MI. Up to 5 controls (n = 884), matched for age, sex, and clinical center, were selected at random with replacement among patients with no history of MI already enrolled in the database when MI was diagnosed in the corresponding case. Conditional logistic regression models were used to adjust for potential confounders. RESULTS: Short-term/recent exposure to abacavir was associated with an increased risk of MI in the overall sample (odds ratios [ORs], 2.01; 95% confidence interval [CI], 1.11-3.64) but not in the subset of matched cases and controls (81%) who did not use cocaine or intravenous drugs (1.27; 0.64-2.49). Cumulative exposure to all PIs except saquinavir was associated with an increased risk of MI significant for amprenavir/fosamprenavir with or without ritonavir (OR, 1.53; 95% CI, 1.21-1.94 per year) and lopinavir with ritonavir (1.33; 1.09-1.61 per year). Exposure to all non-NRTIs was not associated with risk of MI. CONCLUSION: The risk of MI was increased by cumulative exposure to all the studied PIs except saquinavir and particularly to amprenavir/fosamprenavir with or without ritonavir and lopinavir with ritonavir, whereas the association with abacavir cannot be considered causal.


Assuntos
Fármacos Anti-HIV/efeitos adversos , Carbamatos/efeitos adversos , Didesoxinucleosídeos/efeitos adversos , Infecções por HIV/tratamento farmacológico , Infarto do Miocárdio/induzido quimicamente , Organofosfatos/efeitos adversos , Ritonavir/efeitos adversos , Sulfonamidas/efeitos adversos , Adulto , Fármacos Anti-HIV/administração & dosagem , Carbamatos/administração & dosagem , Estudos de Casos e Controles , Estudos de Coortes , Intervalos de Confiança , Didesoxinucleosídeos/administração & dosagem , Feminino , França/epidemiologia , Furanos , Infecções por HIV/diagnóstico , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/epidemiologia , Razão de Chances , Organofosfatos/administração & dosagem , Análise de Regressão , Risco , Ritonavir/administração & dosagem , Sulfonamidas/administração & dosagem
13.
Foodborne Pathog Dis ; 7(6): 613-8, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20156088

RESUMO

Infections with cestodes from genus Echinococcus are usually acquired by oral ingestion of eggs, direct contact with carriers, and contaminated food (especially vegetables) or water. Echinococcosis, previously characterized as a malady of medical importance only, depends upon veterinary solutions and faces political obstacles; it is considered the most important zoonotic disease in Romania. As a result of the increased number of human and animal cases, Romania was framed in the forefront of the European countries and among the first countries worldwide in 1995. The present paper is the first international systematized review concerning echinococcosis in Romania. It covers a period of 146 years, beginning in 1862, when the first case of human hydatid disease was mentioned in medical annals, until 2007 and aims at overviewing and analyzing data provided by major studies from different fields of human and veterinary medicine. Authors also present unpublished data of a 37-year surveillance performed in a reference infectious disease hospital. During the period 1979-1988, 8557 patients were hospitalized for hydatid disease requiring 210,057 days of health care, and 516 fatalities (6.03%) were registered. The prevalence of the disease in livestock during the period 1983-1994 varied between 24.3% and 92.9% in sheep, 31.2% and 43.6% in cattle, and 20.4% and 73.8% in swine. The economic losses in animals are very high due not only to increased mortality rates but also to weight loss and decreased productivity. Epidemiological data available showed that at least one person from 45.5% of Romanian localities underwent surgery for cystic echinococcosis. The information presented outlines the severity of the situation from human- and livestock-associated cystic echinococcosis in Romania. Control programs based on combinations of animal vaccination, dehelmintization of dogs, and education programs should be implemented to achieve effective prevention of disease transmission.


Assuntos
Equinococose/epidemiologia , Equinococose/veterinária , Echinococcus , Zoonoses/epidemiologia , Animais , Animais Domésticos/parasitologia , Anticestoides/uso terapêutico , Equinococose/história , Equinococose/prevenção & controle , História do Século XVIII , História do Século XIX , História do Século XX , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Vacinação em Massa/veterinária , Morbidade , Vigilância da População , Romênia/epidemiologia , Zoonoses/história , Zoonoses/parasitologia
14.
Artigo em Romano | MEDLINE | ID: mdl-21553473

RESUMO

OBJECTIVE: Antibiotic resistance evaluation of Gram-positive cocci isolated in 2008. MATERIAL AND METHODS: Antibiotic susceptibility testing was performed for 1044 strains: 610 Staphylococcus aureus (352 from patients, 258 from carriers), 203 Streptococcus pneumoniae (53 from patients, 150 from carriers), 144 Enterococcus faecalis. 57 Enterococcus faecium and 30 Streptococcus spp. using automatic systems Vitek 2 Compact. MicroScan, disc diffusion method and Etest according to 2008 CLSI. A number of 497 Streptococcus pyogenes strains were tested for eritromycin resistance. RESULTS: There were 33.2% MRSA for strains isolated from patients and 30.0% from carriers. From MRSA strains. 35.5% were resistant to gentamicin. 33.6% to ciprofloxacin, 74.3% to erythromycin and 30.5% to rifampin. There were no S. aureus strain resistant to vancomycin and linezolid. S. aureus strains isolated from wounds were more resistant to erythromycin (43.9%) than the strains isolated from systemic infections (12.1%). From 11 S. pneumoniae strains isolated from meningitis, 4 were resistant to penicillin. Neither S. pneumoniae strain isolated from other infections, nor those from carriers had MIC to penicillin more than 4 microg/ml. S. pneumoniae strains isolated from carriers were more resistant to erythromycin. clindamycin and tetracycline than the strains isolated from patients (66.7%, 54.1%, 54.2% vs. 27.4%, 22.6%, 33.9%). E. faecium was 95.9% resistant to penicillin, 90.2% to ampicillin, 64.7% to gentamicin, 72.0% to streptomycin and 78.4% to ciprofloxacin. F. faecalis was less resistant than E. faecium at most of the antibiotics: 32.4% to gentamicin, 59.6% to streptomycin, 28.5% to ciprofloxacin. Viridans group Streptococci, all isolated from blood culture were 92% susceptible to penicillin and ampicillin. To erythromycin, 12% of viridians group Streptococci were resistant. S. pyogenes resistance to eritromycin was 5.8%. CONCLUSIONS: S. aureus strains showed a relatively high level of resistance to oxacillin (33.2%) and resistance in the same time to several antibiotics. S. pneumoniae can not be considered resistant to penicillin administrated parenteral, with exception of the strains isolated from meningitis. E. faecium had a higher resistance rate than E. faecalis.


Assuntos
Antibacterianos/farmacologia , Resistência Microbiana a Medicamentos , Cocos Gram-Positivos/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Antibacterianos/uso terapêutico , Ciprofloxacino/farmacologia , Enterococcus faecalis/efeitos dos fármacos , Enterococcus faecium/efeitos dos fármacos , Eritromicina/farmacologia , Gentamicinas/farmacologia , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Infecções por Bactérias Gram-Positivas/epidemiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Infecções por Bactérias Gram-Positivas/prevenção & controle , Cocos Gram-Positivos/isolamento & purificação , Hospitais de Isolamento/estatística & dados numéricos , Hospitais Universitários , Humanos , Penicilinas/farmacologia , Rifampina/farmacologia , Romênia/epidemiologia , Staphylococcus aureus/efeitos dos fármacos , Streptococcus pneumoniae/efeitos dos fármacos , Streptococcus pyogenes/efeitos dos fármacos
15.
J Hosp Infect ; 73(1): 15-23, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19647337

RESUMO

Isolation of patients with highly infectious diseases (HIDs) in hospital rooms with adequate technical facilities is essential to reduce the risk of spreading disease. The European Network for Infectious Diseases (EUNID), a project co-funded by European Commission and involving 16 European Union member states, performed an inventory of high level isolation rooms (HIRs, hospital rooms with negative pressure and anteroom). In participating countries, HIRs are available in at least 211 hospitals, with at least 1789 hospital beds. The adequacy of this number is not known and will depend on prevailing circumstances. Sporadic HID cases can be managed in the available HIRs. HIRs could also have a role in the initial phases of an influenza pandemic. However, large outbreaks due to natural or to bioterrorist events will need management strategies involving healthcare facilities other than HIRs.


Assuntos
Doenças Transmissíveis/transmissão , Instalações de Saúde/estatística & dados numéricos , Hospitais de Isolamento/estatística & dados numéricos , Isolamento de Pacientes/métodos , Bioterrorismo , Surtos de Doenças/prevenção & controle , União Europeia , Humanos
16.
Rev Med Chir Soc Med Nat Iasi ; 113(1): 192-6, 2009.
Artigo em Romano | MEDLINE | ID: mdl-21495317

RESUMO

UNLABELLED: We assessed clinical and microbiological characteristics of Staphylococcus aureus (SA) infections in hospitalized patients during a period of three years (October 2005 - October 2008) in the Clinic Hospital of Infectious Diseases Iasi. MATERIAL AND METHODS: The study included 169 patients with SA infections (sepsis, meningitis, skin infections and urinary tract infections). MiniAPI system ID 32 STAPH was used for identification and antibiotic susceptibility was assessed by ATB STAPH method and by E-test for oxacillin and vancomycin. RESULTS: The rate of methicillin resistance (MR) was 48%, all strains being susceptible to linezolid, vancomycin, teicoplanin. In our study MRSA was susceptible in approximately 94% of cases to clindamycin and cotrimoxazole. Infections were defined as nosocomial in 51% of patients with a rate of MR of 52% and community-acquired in 49% with a rate of MR of 23% (p = 0.001). Clinical profile was: localized infection in 41% of patients with MRSA and systemic infection (sepsis with at least one organ involvement or bacteremia) in 59% of patients with MRSA infections (p = 0.53). Initial treatment was inadequate in 46% of MRSA infections. One third of strains had MIC of vancomycin 2 mg/mL. CONCLUSIONS: The high level of methicillin resistance of S. aureus straints isolated from infections (48 %) justifies a particular approach of initial antistaphylococcal therapy.


Assuntos
Infecção Hospitalar , Hospitais de Isolamento/estatística & dados numéricos , Pacientes Internados/estatística & dados numéricos , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/microbiologia , Staphylococcus aureus/isolamento & purificação , Acetamidas/uso terapêutico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Anti-Infecciosos/uso terapêutico , Infecções Comunitárias Adquiridas/epidemiologia , Infecções Comunitárias Adquiridas/microbiologia , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/microbiologia , Quimioterapia Combinada , Hospitais Universitários , Humanos , Linezolida , Resistência a Meticilina , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Oxazolidinonas/uso terapêutico , Estudos Retrospectivos , Romênia/epidemiologia , Infecções Estafilocócicas/tratamento farmacológico , Teicoplanina/uso terapêutico , Vancomicina/uso terapêutico
17.
Rev Med Chir Soc Med Nat Iasi ; 112(3): 612-5, 2008.
Artigo em Romano | MEDLINE | ID: mdl-20201240

RESUMO

UNLABELLED: Leptospirosis is a zooantroponosis manifested as an infection with a severe evolution, with liver and renal failure and haemoragic manifestation. The aim of the study was to present the epidemiologic, clinic and therapeutical aspects of 100 cases of leptospirosis admitted in the clinic of Infectious Diseases of Iasi, during 5 years (2002-2006). MATERIAL AND METHOD: The diagnostic was based on the clinical-biologic study and risk factors with febrile syndrome, mialgic syndrome, headache, meningial, liver and renal failure and hematological syndromes, with the serologic evidence of serotypes of leptospirosis. RESULTS: All the patients were serologic confirmed with leptospirosis. Leptospirosis is an emergent disease with the possibility of severe evolution in some forms, with lever and renal failure.


Assuntos
Hospitais de Isolamento/estatística & dados numéricos , Pacientes Internados/estatística & dados numéricos , Leptospira , Leptospirose/diagnóstico , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Febre/microbiologia , Cefaleia/microbiologia , Hemorragia/microbiologia , Hospitais Universitários , Humanos , Leptospira/isolamento & purificação , Leptospirose/sangue , Leptospirose/epidemiologia , Leptospirose/microbiologia , Falência Hepática/microbiologia , Masculino , Meningismo/microbiologia , Pessoa de Meia-Idade , Doenças Musculares/microbiologia , Prevalência , Insuficiência Renal/microbiologia , Fatores de Risco , Romênia/epidemiologia , Testes Sorológicos
18.
Rev Med Chir Soc Med Nat Iasi ; 112(2): 483-8, 2008.
Artigo em Romano | MEDLINE | ID: mdl-19295024

RESUMO

MATERIAL AND METHOD: Analytical assessment was performed for a sample of 499 patients admitted in the Infectious Diseases Clinic of Iasi, in order to highlight some clinical epidemiological and laboratory characteristics. RESULTS: During the third trimester, 45.3% of patients were hospitalized, comparatively with 7.8% during the first trimester, leading to a summer - autumn seasonality. Age groups of 31-60 years registered 57.3%; 90.2% were males, and only 13.2% agricultural workers. Clinical forms and evolution were assessed by testing a number of 10 biological and biochemical indicators. Leptospira icterohaemorrhagiae was the causal agent in 46.1% of cases, followed by L. wolffi (44.3%), L. pomona (4.2%), and l. grippotyphosa (3.4%). Average length of stay of 11-20 days (42.3%) and over 20 (21.4%) represented an indicator of unfavourable medical and socioeconomic involvements due to leptospirosis.


Assuntos
Pacientes Internados/estatística & dados numéricos , Leptospira/isolamento & purificação , Leptospirose/epidemiologia , Adolescente , Adulto , Idoso , Doenças dos Trabalhadores Agrícolas/epidemiologia , Animais , Antibacterianos/uso terapêutico , Criança , Feminino , Hospitais de Isolamento/estatística & dados numéricos , Humanos , Incidência , Leptospirose/diagnóstico , Leptospirose/tratamento farmacológico , Leptospirose/transmissão , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Estudos Retrospectivos , Romênia/epidemiologia , Estações do Ano , Resultado do Tratamento
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