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1.
BMC Ophthalmol ; 21(1): 255, 2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34107904

RESUMO

BACKGROUND: Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients. PURPOSE: To investigate the changes in cerebral hemispheric functional connections in patients with SA and their relationship with clinical manifestations using the VMHC method. MATERIAL AND METHODS: In the present study, a total of 17 patients with SA (eight males and nine females) and 17 age- and weight-matched healthy control (HC) groups were enrolled. Based on the VMHC method, all subjects were examined by functional magnetic resonance imaging. The functional interaction between cerebral hemispheres was directly evaluated. The Pearson's correlation test was used to analyze the clinical features of patients with SA. In addition, their mean VMHC signal values and the receiver operating characteristic curve were used to distinguish patients with SA and HC groups. RESULTS: Compared with HC group, patients with SA had higher VMHC values in bilateral cingulum ant, caudate, hippocampus, and cerebellum crus 1. Moreover, the VMHC values of some regions were positively correlated with some clinical manifestations. In addition, receiver operating characteristic curves presented higher diagnostic value in these areas. CONCLUSION: SA subjects showed abnormal brain interhemispheric functional connectivity in visual pathways, which might give some instructive information for understanding the neurological mechanisms of SA patients.


Assuntos
Ambliopia , Imageamento por Ressonância Magnética , Encéfalo , Feminino , Humanos , Masculino , Fibras Nervosas
2.
Zhejiang Da Xue Xue Bao Yi Xue Ban ; 50(1): 97-105, 2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-34117849

RESUMO

:To explore the value of quantitative perfusion histogram parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in pathological classification of uterine leiomyoma and its correlation with Ki-67 protein expression. Thirty five patients with uterine leiomyoma confirmed by operation and pathology at Shaoxing People's Hospital from October 2015 to September 2017 were analyzed retrospectively,including 15 cases of ordinary type,8 cases of cellular type and 12 cases of degenerative type. All patients were examined by pelvic DCE-MRI before operation,and the histogram parameters (median,mean,skewness,kurtosis,energy,entropy) of various quantitative perfusion parameters,including volume transport constant (K),rate constant (K),extravascular extracellular space distribute volume per unit tissue volume (V),blood plasma volume per unit volume of tissue (V) were calculated,and the efficacy of different parameters in pathological classification of uterine leiomyoma was evaluated by ROC curve. The expression of Ki-67 protein in uterine leiomyoma was detected by immunohistochemical method,and the correlation between histogram parameters and Ki-67 protein expression was analyzed by Pearson and Spearman correlation analysis. The median and mean values of K,K,V and V in the cellular group were higher than those in the degenerative group and the ordinary group(<0.05 or <0.01),while the skewness of V,the skewness and kurtosis of K in the cellular group were lower than those in the ordinary group (all <0.05). The entropy of K in the cellular group was higher than that in the degenerative group and the ordinary group (all < 0.05). The entropy of V in the cellular group was higher than that in the ordinary group (<0.01). The median,mean,skewness of K,median and mean of K,median and mean of V,median,mean,energy and entropy of V were correlated with Ki-67 expression(all <0.05). The results of ROC curve analysis showed that the median threshold of K was 0.994/min,the sensitivity and specificity for the diagnosis of cellular uterine leiomyoma were 100.0% and 77.8% respectively,and the area under the ROC curve was 0.949. When the mean threshold of K was 1.170/min,the sensitivity and specificity for diagnosing cellular uterine leiomyoma were 100.0% and 77.8% respectively,and the area under the ROC curve was 0.958. The area under the ROC curve of K (entropy),K (median,mean),V (median,mean,entropy) in the diagnosis of cellular uterine leiomyoma were 0.755-0.907. :DCE-MRI quantitative perfusion histogram parameters have high diagnostic value in differentiating pathological types of uterine leiomyoma,especially for cellular uterine leiomyoma.


Assuntos
Meios de Contraste , Leiomioma , Humanos , Leiomioma/diagnóstico por imagem , Imageamento por Ressonância Magnética , Perfusão , Estudos Retrospectivos
3.
BMC Musculoskelet Disord ; 22(1): 536, 2021 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-34118908

RESUMO

BACKGROUND: Degenerative lumbar spinal stenosis (DLSS) is a common degenerative condition in older adults. Muscle atrophy (MA) is a leading cause of muscle weakness and disability commonly reported in individuals with spinal stenosis. The purpose of this study was to investigate if the MA correlates with the grade of spinal stenosis in patients with DLSS. METHODS: A retrospective analysis on 48 male and 184 female DLSS patients aged around 54.04 years (54.04 ± 8.93) were involved and divided into 6 groups according to claudication-distance-based grading of spinal stenosis, which confirmed by two independent orthopedic surgeons using T2- weighted images. Using 1.5T MRI scanner, the severity of MA is assessed based on its negative correlation with the ratio of total fat-free multifidus muscle cross-sectional area (TFCSA) to total multifidus muscle cross-sectional area (TCSA). Adobe Photoshop CS6 was used for qualitative image analysis and calculate the TFCSA/TCSA ratio to assess the severity of MA, compare the grade of MA with the spinal stenosis segment, stenosis grade and symptom side. RESULTS: In DLSS group, The TFCSA/TCSA ratio are 74.33 ± 2.18 in L3/4 stenosis, 75.51 ± 2.79 in L4/5 stenosis, and 75.49 ± 2.69 in L5/S1 stenosis. there were significant decreases in the TFCSA/TCSA ratio of stenotic segments compared with non-stenotic segments of the spinal canal (P < 0.05) while no significant difference between the non-stenotic segments (P > 0.05). TFCSA/TCSA ratios is significant differences in the TFCSA/TCSA ratios of the 6 DLSS groups (F = 67.832; P < 0.05). From Group 1 to Group 6, the TFCSA/TCSA ratio of stenotic segments positively correlated with the absolute claudication distance (ACD). (P < 0.001, r = 0.852). Besides, the TFCSA/TCSA ratios are smaller in the symptomatic sides of the spine than the contralateral sides (t = 4.128, P = 0.001). CONCLUSIONS: The stenotic segments of the spinal canal are more atrophied than the non-stenotic segment in DLSS patients. It is shows that a strong positive correlation between the severity of multifidus atrophy and the severity of spinal stenosis.


Assuntos
Estenose Espinal , Idoso , Feminino , Humanos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/patologia , Imageamento por Ressonância Magnética , Masculino , Atrofia Muscular/diagnóstico por imagem , Atrofia Muscular/etiologia , Atrofia Muscular/patologia , Músculos Paraespinais/diagnóstico por imagem , Músculos Paraespinais/patologia , Estudos Retrospectivos , Estenose Espinal/complicações , Estenose Espinal/diagnóstico por imagem , Estenose Espinal/patologia
4.
Wien Klin Wochenschr ; 133(11-12): 560-567, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34081188

RESUMO

OBJECTIVE: The purpose was to introduce the Vienna morphological Achilles tendon score (VIMATS), to evaluate its reproducibility and to assess its clinical application. METHODS: In 38 patients a total number of 40 painful ATs and 20 volunteers were examined on a 3T magnetic resonance imaging (MRI) scanner using a standard MRI protocol. In 20 patients clinical scoring according to the Achilles tendon rupture score was available. Two observers independently assessed the thickness, continuity, signal intensity, and associated pathologies of the Achilles tendon (AT) according to the newly created VIMATS. Intraobserver and interobserver agreements were calculated and the clinical application of the VIMATS regarding its potential to differentiate between patients and volunteers was tested. RESULTS: An analysis of the Intraclass correlation coefficient (ICC) yielded an excellent intraobserver (ICC 0.925) and interobserver agreement (ICC 0.946) for the total VIMAT score. A significant difference in total VIMATS was found between patients (47.6 ± StD 21.1 points) and volunteers (91.5 ± SD 10.9 points; p < 0.01) as well as a moderate correlation between morphological and clinical scoring (Pearson correlation 0.644). CONCLUSION: The VIMAT score is the first MRI score for the semiquantitative morphological evaluation of AT injuries and was shown to be an easy, fast and reproducible tool for assessing injuries of the AT.


Assuntos
Tendão do Calcâneo , Traumatismos dos Tendões , Tendão do Calcâneo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Reprodutibilidade dos Testes
5.
Medicine (Baltimore) ; 100(22): e25468, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34087819

RESUMO

RATIONALE: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a condition characterized by biphasic convulsions and disturbance of consciousness. In Japan, the most common pediatric cases of acute encephalopathy are associated with infection. AESD usually occurs in early childhood, with the characteristic magnetic resonance imaging (MRI) appearance called "bright tree appearance." The disease often has neurological sequelae and interferes with the schooling of children and their activities of daily living; however, there are few clinical case reports of hemiplegia caused by AESD. PATIENT CONCERNS: A case with right-sided hemiplegia due to AESD in an 11-month-old girl who was followed up to 30 mo of age. DIAGNOSES: The patient was diagnosed with overlap AESD and hemiconvulsion-hemiplegia-epilepsy syndrome (HHE syndrome), based on the clinical course and imaging findings. DNA tests of her blood and cerebrospinal fluid revealed the presence of human herpesvirus 6. INTERVENTIONS: Pharmacotherapy and rehabilitation therapy. OUTCOME: Gross motor function has recovered considerably, but she had a mild developmental delay at 30 mo old. LESSONS: Hemiplegia due to AESD was extremely rare, and appropriate rehabilitation treatment resulted in recovery of physical function. However, as mild developmental delay was observed, the patient was referred to a specialized facility before entering school.


Assuntos
Encefalopatia Aguda Febril/complicações , Hemiplegia/etiologia , Anticonvulsivantes/uso terapêutico , Feminino , Hemiplegia/tratamento farmacológico , Hemiplegia/reabilitação , Humanos , Lactente , Imageamento por Ressonância Magnética
6.
Pan Afr Med J ; 38: 241, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34104289

RESUMO

Ganglioneuromas are benign slow-growing lesions that arise from sympathetic ganglion cells. They are usually found incidentally. Ultrasound and magnetic resonance imaging (MRI), provides only an unspecified diagnosis and it has to be confirmed by pathologic studies. Complete surgical excision is believed to be the curative treatment for symptomatic lesions. In the literature, the pelvic location reported is exceptional. We report a case of laparoscopic assisted excision of a retrorectal presacral ganglioneuroma for 22-year-old female patient.


Assuntos
Ganglioneuroma/cirurgia , Laparoscopia , Neoplasias Retais/cirurgia , Feminino , Ganglioneuroma/diagnóstico por imagem , Ganglioneuroma/patologia , Humanos , Imageamento por Ressonância Magnética , Neoplasias Retais/diagnóstico por imagem , Neoplasias Retais/patologia , Ultrassonografia , Adulto Jovem
7.
BMC Neurol ; 21(1): 219, 2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34107918

RESUMO

BACKGROUND: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is an adult-onset rare monogenic microvasculopathy. Its typical neuroimaging features are punctate white matter lesions or pseudotumor alterations. RVCL-S is often under-recognized and misdiagnosed because of its rarity and similar imaging manifestations to multiple sclerosis or brain malignant mass. CASE PRESENTATION: Here we report a case of a 36-year-old Chinese man who developed multiple tumefactive brain lesions spanning over two years leading to motor aphasia, cognitive decline, and limb weakness. He also presented with slight vision loss, and fundus fluorescein angiography indicated retinal vasculopathy. He underwent brain biopsies twice and showed no evidence of malignancy. Given the family history that his father died of a brain mass of unclear etiology, RVCL-S was suspected, and genetic analysis confirmed the diagnosis with a heterozygous insertion mutation in the three-prime repair exonuclease 1 gene. He was given courses of corticosteroids and cyclophosphamide but received little response. CONCLUSIONS: The present case is one of the few published reports of RVCL-S with two-year detailed imaging data. Serial magnetic resonance images showed the progression pattern of the lesions. Our experience emphasizes that a better understanding of RVCL-S and considering it as a differential diagnosis in patients with tumefactive brain lesions may help avoid unnecessary invasive examinations and make an earlier diagnosis.


Assuntos
Leucoencefalopatias/diagnóstico por imagem , Imageamento por Ressonância Magnética/métodos , Doenças Vasculares/diagnóstico , Adulto , Encéfalo/patologia , Disfunção Cognitiva/diagnóstico , Diagnóstico Diferencial , Heterozigoto , Humanos , Leucoencefalopatias/genética , Masculino , Neuroimagem
8.
J Pak Med Assoc ; 71(6): 1701-1702, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34111104

RESUMO

Abdominal wall sarcoma belongs to a heterogeneous group of uncommon malignant neoplastic conditions with differentiated morphological patterns and originating from mesenchymal tissues. Soft tissue sarcomas predominantly involve the lower and upper limbs and retroperitoneum. We present a case of a 30-year-old patient, complaining of swelling in the left flank whose magnetic resonance imaging (MRI) revealed a solid tumour on the abdominal wall of the flank and biopsy turned out to be synovial sarcoma.


Assuntos
Parede Abdominal , Sarcoma Sinovial , Parede Abdominal/diagnóstico por imagem , Adulto , Biópsia , Humanos , Imageamento por Ressonância Magnética , Sarcoma Sinovial/diagnóstico por imagem
9.
BMJ Case Rep ; 14(5)2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059529

RESUMO

Arterial dissection is an uncommon cause of paediatric stroke. Medical therapy remains first-line for treatment. There are few reports of neurovascular stents for paediatric intracranial arterial dissection. Two adolescents presented with neurological deficits and CT angiography concerning for supraclinoid internal carotid artery stenosis. The diagnosis of dissection was secured through a combination of vessel wall MRI and digital subtraction angiography. The patients experienced progressive ischaemic symptoms, despite medical management including anticoagulation, and required stenting. The stents used were a Neuroform EZ and an Atlas. Both patients recovered to Modified Rankin Scale (mRS) 0 and had restored vessel calibre on 6-month follow-up digital subtraction angiography. Neurovascular stents can be used to treat progressively symptomatic intracranial arterial dissections in the paediatric population if medical therapy fails.


Assuntos
Aneurisma Dissecante , Acidente Vascular Cerebral , Adolescente , Aneurisma Dissecante/diagnóstico por imagem , Aneurisma Dissecante/cirurgia , Criança , Dissecação , Humanos , Imageamento por Ressonância Magnética , Stents
10.
Kyobu Geka ; 74(6): 453-456, 2021 Jun.
Artigo em Japonês | MEDLINE | ID: mdl-34059591

RESUMO

A 48-year-old man was referred to our hospital with an intrapericardial mass, which was incidentally found by computed tomography( CT) in a health check-up. He had undergone surgical closure of atrial septal defect 23 years ago. Although echocardiography and CT revealed compression of the right ventricle by a mass, he had no symptoms and echocardiography revealed no significant right ventricular overload. Magnetic resonance imaging revealed a mosaic pattern of various signal intensities. We performed a CT-guided biopsy, and the histological result was a hematoma. This was the first reported case of chronic expanding hematoma following previous cardiac surgery diagnosed by CT-guided biopsy.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Tomografia Computadorizada por Raios X , Hematoma/diagnóstico por imagem , Hematoma/etiologia , Humanos , Biópsia Guiada por Imagem , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade
11.
Radiologe ; 61(6): 532-540, 2021 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-34061214

RESUMO

CLINICAL PROBLEM: Imaging plays a major role to differentiate interstitial edematous from necrotic pancreatitis and to describe relevant local complications for proper patient management and decision-making in acute pancreatitis. STANDARD RADIOLOGICAL PROCEDURES: The revised Atlanta classification 2012 of acute pancreatitis divides patients into mild, moderately severe and severe groups. Computed tomography (CT) and magnetic resonance imaging (MRI) are well established for diagnosis and follow-up of acute pancreatitis and its complications METHODOLOGICAL INNOVATIONS AND ASSESSMENT: Based on the revised Atlanta classification, CT and MRI allow for adequate categorization of interstitial edematous and necrotic pancreatitis. Imaging and standardized reporting nomenclature enable confident differentiation of early and late complications in acute pancreatitis. RECOMMENDATIONS: The aim of this review article is to present an image-rich overview of different morphologic characteristics of acute pancreatitis and associated local complications by CT or MRI using case examples.


Assuntos
Pancreatite , Doença Aguda , Humanos , Imageamento por Ressonância Magnética , Necrose , Pancreatite/diagnóstico por imagem , Tomografia Computadorizada por Raios X
12.
Int J Mol Sci ; 22(10)2021 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-34067989

RESUMO

Magnetic resonance imaging (MRI) is often used to diagnose diseases due to its high spatial, temporal and soft tissue resolution. Frequently, probes or contrast agents are used to enhance the contrast in MRI to improve diagnostic accuracy. With the development of molecular imaging techniques, molecular MRI can be used to obtain 3D anatomical structure, physiology, pathology, and other relevant information regarding the lesion, which can provide an important reference for the accurate diagnosis and treatment of the disease in the early stages. Among existing contrast agents, smart or activatable nanoprobes can respond to selective stimuli, such as proving the presence of acidic pH, active enzymes, or reducing environments. The recently developed environment-responsive or smart MRI nanoprobes can specifically target cells based on differences in the cellular environment and improve the contrast between diseased tissues and normal tissues. Here, we review the design and application of these environment-responsive MRI nanoprobes.


Assuntos
Meios de Contraste/química , Imageamento por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/normas , Nanopartículas de Magnetita/química , Sondas Moleculares/química , Humanos
13.
Int J Mol Sci ; 22(10)2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34068875

RESUMO

Atherosclerosis is at the onset of the cardiovascular diseases that are among the leading causes of death worldwide. Currently, high-risk plaques, also called vulnerable atheromatous plaques, remain often undiagnosed until the occurrence of severe complications, such as stroke or myocardial infarction. Molecular imaging agents that target high-risk atheromatous lesions could greatly improve the diagnosis of atherosclerosis by identifying sites of high disease activity. Moreover, a "theranostic approach" that combines molecular imaging agents (for diagnosis) and therapeutic molecules would be of great value for the local management of atheromatous plaques. The aim of this study was to develop and characterize an innovative theranostic tool for atherosclerosis. We engineered oil-in-water nano-emulsions (NEs) loaded with superparamagnetic iron oxide (SPIO) nanoparticles for magnetic resonance imaging (MRI) purposes. Dynamic MRI showed that NE-SPIO nanoparticles decorated with a polyethylene glycol (PEG) layer reduced their liver uptake and extended their half-life. Next, the NE-SPIO-PEG formulation was functionalized with a fully human scFv-Fc antibody (P3) recognizing galectin 3, an atherosclerosis biomarker. The P3-functionalized formulation targeted atheromatous plaques, as demonstrated in an immunohistochemistry analyses of mouse aorta and human artery sections and in an Apoe-/- mouse model of atherosclerosis. Moreover, the formulation was loaded with SPIO nanoparticles and/or alpha-tocopherol to be used as a theranostic tool for atherosclerosis imaging (SPIO) and for delivery of drugs that reduce oxidation (here, alpha-tocopherol) in atheromatous plaques. This study paves the way to non-invasive targeted imaging of atherosclerosis and synergistic therapeutic applications.


Assuntos
Aterosclerose/patologia , Emulsões , Nanopartículas de Magnetita/administração & dosagem , Imagem Molecular/métodos , Anticorpos de Cadeia Única/imunologia , Nanomedicina Teranóstica/métodos , Animais , Aterosclerose/imunologia , Meios de Contraste , Feminino , Humanos , Imageamento por Ressonância Magnética , Nanopartículas de Magnetita/química , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout para ApoE , Polietilenoglicóis
14.
Georgian Med News ; (313): 20-25, 2021 Apr.
Artigo em Russo | MEDLINE | ID: mdl-34103424

RESUMO

Damage of the medial meniscus root is critical, because it leads to rapid progression of knee osteoarthritis and requires surgical treatment. Purpose - to evaluate results of surgical treatment in patients with degenerative medial meniscus root tear with 1st and 2nd K-L knee osteoarthritis. The results of treatment of 55 patients with degenerative medial meniscus root tears were evaluated. MRI and arthroscopy were used for diagnosis. Patients were divided into the main group (nо=18) and comparison group (nс=37) patients. In the comparison group, a partial meniscectomy was performed (nс=37), which consisted of the removal of the damaged posterior horn and part of the body of the medial meniscus under arthroscopic control. In the main group (nо=18) the suture of the medial meniscus root was performed under arthroscopic control. Before surgery, the score on the Lyscholm scale in patients of the main group (n=18) was 62.5±4.6 points, in the comparison group (n=37) - 63.8±4.2 points (p>0.05).One year after surgery, the score on the Lyscholm scale in patients of the main group (n=18) 88.5±6.1 points, in the comparison group (n=37) - 82,8±5,2 points (p<0.05). Two year after surgery, the score on the Lyscholm scale in patients of the main group (n=18) 87,3±4,1 points, in the comparison group (n=37) - 81,5±6,2 points (p<0.05). The suture of the medial meniscus root is the method of choice that allows to get better clinical results compared to partial meniscectomy, as well as slowdown the development of knee osteoarthritis.


Assuntos
Osteoartrite do Joelho , Lesões do Menisco Tibial , Artroscopia , Humanos , Imageamento por Ressonância Magnética , Meniscos Tibiais/diagnóstico por imagem , Meniscos Tibiais/cirurgia , Osteoartrite do Joelho/diagnóstico por imagem , Osteoartrite do Joelho/cirurgia , Lesões do Menisco Tibial/diagnóstico por imagem , Lesões do Menisco Tibial/cirurgia
15.
Medicina (Kaunas) ; 57(5)2021 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-34063687

RESUMO

Background and Objective: Breast implant surgery for cosmetic purposes is the most popular plastic surgery and it has been performed for over 100 years. Rupture of silicone gel-filled breast implants usually is asymptomatic and is one of the more dangerous complications due to free silicone migration. The aim of our study was to evaluate the diagnostic value of ultrasound (US) in the evaluation of the integrity of silicone breast implants and identify the main sign of intact and ruptured breast implants. Patients and Methods: In this retrospective study, the medical documentation of women who underwent breast implant surgery and US checkups at Tautrimas Astrauskas Clinic in Kaunas, Lithuania, during 2015-2020 was analyzed. The patients were divided into two groups: patients with intact and ruptured breast implants. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) as well as the signs of implant integrity of US examination were evaluated. Results: In this study, 76 women with bilateral breast implants (n = 152) were reviewed. On a US examination, ruptured implants were found in 41.1% (n = 61) of the cases; of them, 78.7% (n = 48) of the cases had ≥2 US signs of a ruptured implant, and in all these cases, implant rupture was confirmed at surgery. Overall, one US sign of a ruptured implant was found in 21.3% (n = 13) of the cases. Of them, inhomogeneous content in all cases (n = 3) was found in the intact implant group, and an abnormal implant shell was documented more often in the ruptured implant group, not intact one (n = 9, 90% vs. n = 1, 10%). US had a diagnostic accuracy of 94.7%, sensitivity of 98.3%, specificity of 89.2%, PPV of 93.4%, and NPV of 97.1% in the evaluation of implant integrity. Conclusions: Our results show that US is a very reliable alternative in evaluating breast implant integrity and could be the investigation of choice for implant rupture, while MRI could be advocated only in inconclusive cases. Uneven implant shell was found to be the most important US sign of breast implant rupture. Based on the findings, we recommend performing US examination after breast augmentation surgery with silicone gel-filled implants annually.


Assuntos
Implantes de Mama , Implantes de Mama/efeitos adversos , Feminino , Humanos , Lituânia , Imageamento por Ressonância Magnética , Falha de Prótese , Estudos Retrospectivos , Géis de Silicone/efeitos adversos
16.
Artigo em Inglês | MEDLINE | ID: mdl-34063854

RESUMO

Breast cancer (BC) is the cancer with the highest incidence in women in the world. In this last period, the COVID-19 pandemic has caused in many cases a drastic reduction of routine breast imaging activity due to the combination of various factors. The survival of BC is directly proportional to the earliness of diagnosis, and especially during this period, it is at least fundamental to remember that a diagnostic delay of even just three months could affect BC outcomes. In this article we will review the state of the art of breast imaging, starting from morphological imaging, i.e., mammography, tomosynthesis, ultrasound and magnetic resonance imaging and contrast-enhanced mammography, and their most recent evolutions; and ending with functional images, i.e., magnetic resonance imaging and contrast enhanced mammography.


Assuntos
Neoplasias da Mama , COVID-19 , Neoplasias da Mama/diagnóstico por imagem , Diagnóstico Tardio , Feminino , Humanos , Imageamento por Ressonância Magnética , Mamografia , Pandemias , SARS-CoV-2
17.
Sensors (Basel) ; 21(11)2021 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-34073315

RESUMO

Cardiac MRI left ventricular (LV) detection is frequently employed to assist cardiac registration or segmentation in computer-aided diagnosis of heart diseases. Focusing on the challenging problems in LV detection, such as the large span and varying size of LV areas in MRI, as well as the heterogeneous myocardial and blood pool parts in LV areas, a convolutional neural network (CNN) detection method combining discriminative dictionary learning and sequence tracking is proposed in this paper. To efficiently represent the different sub-objects in LV area, the method deploys discriminant dictionary to classify the superpixel oversegmented regions, then the target LV region is constructed by label merging and multi-scale adaptive anchors are generated in the target region for handling the varying sizes. Combining with non-differential anchors in regional proposal network, the left ventricle object is localized by the CNN based regression and classification strategy. In order to solve the problem of slow classification speed of discriminative dictionary, a fast generation module of left ventricular scale adaptive anchors based on sequence tracking is also proposed on the same individual. The method and its variants were tested on the heart atlas data set. Experimental results verified the effectiveness of the proposed method and according to some evaluation indicators, it obtained 92.95% in AP50 metric and it was the most competitive result compared to typical related methods. The combination of discriminative dictionary learning and scale adaptive anchor improves adaptability of the proposed algorithm to the varying left ventricular areas. This study would be beneficial in some cardiac image processing such as region-of-interest cropping and left ventricle volume measurement.


Assuntos
Ventrículos do Coração , Redes Neurais de Computação , Algoritmos , Ventrículos do Coração/diagnóstico por imagem , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética
18.
Nat Commun ; 12(1): 3289, 2021 06 02.
Artigo em Inglês | MEDLINE | ID: mdl-34078897

RESUMO

Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.


Assuntos
Tronco Encefálico/patologia , AVC Isquêmico/patologia , Córtex Sensório-Motor/patologia , Tálamo/patologia , Idoso , Idoso de 80 Anos ou mais , Teorema de Bayes , Mapeamento Encefálico , Tronco Encefálico/irrigação sanguínea , Tronco Encefálico/diagnóstico por imagem , Revascularização Cerebral/métodos , Estudos de Coortes , Feminino , Humanos , Processamento de Imagem Assistida por Computador , AVC Isquêmico/diagnóstico por imagem , AVC Isquêmico/terapia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Córtex Sensório-Motor/irrigação sanguínea , Córtex Sensório-Motor/diagnóstico por imagem , Índice de Gravidade de Doença , Fatores Sexuais , Tálamo/irrigação sanguínea , Tálamo/diagnóstico por imagem , Resultado do Tratamento
19.
Medicine (Baltimore) ; 100(22): e26242, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34087911

RESUMO

RATIONALE: A special case of transient oculomotor nerve palsy after cerebral angiography. PATIENT CONCERNS: A 55-year-old man developed oculomotor nerve dysfunction after right radial artery puncture angiography. DIAGNOSES: Cerebral angiography-induced oculomotor nerve palsy. INTERVENTIONS: According to the patient's disease state, intravenous drip of dexamethasone 10 mg/d. OUTCOMES: Magnetic resonance imaging (MRI) showed no abnormalities, and the patient recovered completely after 48 hours of hormone therapy. LESSONS: Transient eye palsy caused by contrast agent encephalopathy is a clinically rare neurological dysfunction caused by adverse effects of contrast agents. Early prevention and correct treatment are critical.


Assuntos
Angiografia Cerebral/efeitos adversos , Doenças do Nervo Oculomotor/etiologia , Oftalmoplegia/etiologia , Administração Intravenosa , Assistência ao Convalescente , Meios de Contraste/efeitos adversos , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Encefalite/induzido quimicamente , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Doenças do Nervo Oculomotor/fisiopatologia , Oftalmoplegia/diagnóstico , Oftalmoplegia/tratamento farmacológico , Artéria Radial/cirurgia , Resultado do Tratamento
20.
Rev Med Chil ; 149(1): 76-87, 2021 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-34106138

RESUMO

Amyloid angiopathy (AA) is a selective deposition of amyloid in the walls of the brain vessels. It is a form of sporadic and localized amyloidosis, constituted by the Aß4 protein, the same of Alzheimer's disease senile plaques. The most consistent clinical effect of AA is spontaneous brain hemorrhage (BH). It is the second most common cause of BH after arterial hypertension (HT). Other clinical manifestations are cognitive impairment and transient focal neurological episodes. AA BH is characteristically localized in the cerebral cortex and subcortical white matter (lobar hemorrhage), consistent with the preferential deposit of amyloid in the walls of leptomeningeal and intracortical small cerebral vessels. Other types of AA hemorrhagic complications are microbleeds (MB), cerebral convexity subarachnoid hemorrhage (cSAH) and superficial hemosiderosis (cSS). The diagnosis of AA BH is based on the Boston criteria. Using these criteria, several non-hemorrhagic biomarkers of AA have been identified that can be useful in its diagnosis. The principal AA BH risk factor is age, followed by cSS, MB, Apolipoprotein E gen ε2 and ε4 alleles, HT and the use of antithrombotics. This condition has a high recurrence rate that shares the same risk factors. There is no specific treatment for AA BH. It has a better prognosis than HT BH during the acute period, but worse on the long term, due to its high recurrence rate and cognitive impairment.


Assuntos
Angiopatia Amiloide Cerebral , Hemorragia Subaracnóidea , Encéfalo/diagnóstico por imagem , Angiopatia Amiloide Cerebral/complicações , Hemorragia Cerebral , Humanos , Hemorragias Intracranianas , Imageamento por Ressonância Magnética
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