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1.
J Endod ; 46(3): 444-448, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31959483

RESUMO

Peri-implantitis is becoming a frequent complication observed around dental implants. An endodontic infection of a nearby tooth or an immediate implant placement in an inflamed bone socket from failing endodontic therapy has been associated with retrograde peri-implantitis (RPI), a condition that presents with radiographic lucency at the "apex" of an implant. However, current classification schemes do not capture endodontic lesions that may manifest as coronal or intrabony lesions associated with dental implants. As a result, such cases may be mistreated. Here we present for the first time 2 cases in which peri-implant bone loss occurred in the coronal half of the implant adjacent to a tooth with an endodontic-periodontic lesion and was resolved via endodontic therapy or tooth extraction as indicated. This proof of concept report aimed to introduce endodontic peri-implant ("endo-implant") defects and increase vigilance, which may help prevent overtreatment or mistreatment of such cases.


Assuntos
Perda do Osso Alveolar , Implantes Dentários , Peri-Implantite , Assistência Odontológica , Implantes Dentários/efeitos adversos , Humanos , Peri-Implantite/etiologia , Peri-Implantite/terapia , Periodontia , Extração Dentária
2.
Arch Oral Biol ; 109: 104588, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31669922

RESUMO

OBJECTIVE: Dental occlusion are frequently changed in clinic. Molecular responses in jaw muscles to aberrant dental occlusion are changes are attractive, yet remain are obscure. DESIGN: Unilateral anterior crossbite (UAC) prostheses were applied to Sprague-Dawley rats and then ceased after two weeks to detect the reactions of the masseter, a representative jaw elevator, and the lateral pterygoid muscle (LPM), a representative jaw depressor. RESULTS: Two weeks of UAC elicited mild injury of the two muscles. Myogenesis and protective reactions were detected as increases in αB-crystallin expression in the masseter after 3 days and in the LPM after 2 weeks, and increases in desmin expression in both muscles after 2 weeks. A switch in fibre types from IIb to IIx occurred in the LPM but not in the masseter. Inflammatory responses, shown by the infiltration of inflammatory cells and increases in TNF-α mRNA expression, and fibrosis responses, shown by increased mRNA expression of Type I and III collagens, appeared very mild in the two muscles. These responses were partially recovered by the cessation of UAC. During the whole process, no obvious changes were observed in mitochondrial function, as indicated by the levels of proliferator-activated receptor γ coactivator 1α, mitofusin-2 and voltage-dependent anion channel. CONCLUSIONS: UAC causes injury and very limited inflammatory and fibrosis adaption in the masseter and LPM. Both muscles respond with myogenesis and protective activity. The LPM responds also with muscle fibre isoform alternations. These alterations were partially recovered by the cessation of dental stimulation at an early stage.


Assuntos
Implantes Dentários/efeitos adversos , Má Oclusão , Músculo Masseter/fisiopatologia , Músculos Pterigoides/fisiopatologia , Animais , Fibrose , Inflamação , Arcada Osseodentária , Músculo Masseter/lesões , Fibras Musculares Esqueléticas , Músculos Pterigoides/lesões , Ratos , Ratos Sprague-Dawley
3.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 54(12): 855-858, 2019 Dec 09.
Artigo em Chinês | MEDLINE | ID: mdl-31874488

RESUMO

The peri-implantitis, one of the complications of dental implant surgery, has been bothered clinicians and researchers experts and scholars. Recently, laser, as an adjuvant therapy, has been applied to the treatment of peri-implantitis and achieved satisfactory results. The present review summarized the safety application of laser treatment for peri-implantitis.


Assuntos
Implantes Dentários/efeitos adversos , Terapia a Laser , Peri-Implantite/terapia , Humanos , Lasers
4.
Clin Implant Dent Relat Res ; 21(6): 1218-1224, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31709730

RESUMO

BACKGROUND: There are no studies that have evaluated the correlation between self-rated pain, peri-implant clinical and radiographic parameters (plaque index [PI], bleeding on probing [BOP], probing depth [PD], and crestal bone loss [CBL]) and whole salivary interleukin (IL)-1ß, IL-6, and tumor necrosis factor-alpha (TNF-α) levels among patients with and without peri-implantitis. PURPOSE: The objective was to evaluate the correlation between self-evaluated pain, peri-implant clinical and radiographic parameters and whole salivary IL-1ß, IL-6, and TNF-α levels among patients with and without peri-implantitis. MATERIALS AND METHODS: Included in this study were patients with and without peri-implantitis. Data regarding age, gender, duration of implants in function, and self-perceived pain were recorded using a question. Self-rated pain was assessed using the numeric pain rating scale. Peri-implant PD, PI, BOP, and CBL were recorded and samples of unstimulated whole saliva samples were obtained. Whole salivary IL-1ß, IL-6, and TNF-α were measured. Sample-size was approximated and group comparisons were completed. P-values <.05 were regarded as statistically significant. RESULTS: Forty-six male individuals (21 with and 25 without peri-implantitis) were included. The mean age of individuals with and without PiD was 53.71 ± 5.45 and 50.92 ± 6.26 years, respectively. The mean self-rated pain score in patients with and without PiD was 3 ± 2 and zero, respectively. There was no significant difference in the SFR among patients with and without peri-implantitis. Levels of IL-1ß (P < .01), IL-6 (P < .01), and TNF-α (P < .01) were significantly elevated in subjects with than without peri-implantitis. Regression analysis-based results reflected no significant association between increasing self-rated pain and whole salivary IL-1ß, IL-6, and TNF-α levels. CONCLUSION: Proinflammatory cytokines (IL-1ß, IL-6, and TNF-α) are more often expressed in the UWS of patients with than without peri-implantitis. However, the correlation between self-rated pain and whole salivary proinflammatory cytokine profile in patients with peri-implantitis remains unclear.


Assuntos
Implantes Dentários , Dor , Peri-Implantite , Implantes Dentários/efeitos adversos , Índice de Placa Dentária , Humanos , Masculino , Pessoa de Meia-Idade , Fator de Necrose Tumoral alfa
6.
Georgian Med News ; (294): 46-50, 2019 Sep.
Artigo em Russo | MEDLINE | ID: mdl-31687948

RESUMO

In the era of modern technology is becoming increasingly popular implantation. This method is one of the leading methods in prosthetics of dental patients. Implantation solves a number of problems both aesthetic and functional. However, the percentage of complications, such as peri-implantitis and mucositis, leading to a violation of the chewing function of the dentition, is steadily increasing. To date, the etiology and pathogenesis of post-implantation complications have not been definitively clarified. One of the leading predictors is psychoemotional stress. On the basis of the literature analysis method to study stress, its impact on the development of periimplantitis, is laser Doppler flowmetry, allows you to quickly assess the state of microcirculation of the oral cavity at the stage of diagnosis, prior to the commencement of pharmacotherapy and in the dynamics of treatment and to adjust treatment regimen to prevent postoperative complications. The obtained LDF-grams allow to reflect the state of the regulatory systems of the body, and therefore it is possible to use LDF for the diagnosis of psychological stress.


Assuntos
Implantes Dentários/efeitos adversos , Implantes Dentários/microbiologia , Mucosite/microbiologia , Peri-Implantite/microbiologia , Infecções Relacionadas à Prótese/microbiologia , Humanos , Fluxometria por Laser-Doppler , Microcirculação , Mucosa Bucal/microbiologia , Mucosite/complicações , Peri-Implantite/complicações , Complicações Pós-Operatórias , Infecções Relacionadas à Prótese/etiologia
7.
Braz Oral Res ; 33(suppl 1): e067, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576951

RESUMO

Peri-implantitis is currently a topic of major interest in implantology. Considered one of the main reasons of late implant failure, there is an emerged concern whether implant characteristics could trigger inflammatory lesion and loss of supporting bone. The purpose of this narrative review is to provide an evidence based overview on the influence of implant-based factors in the occurrence of peri-implantitis. A literature review was conducted addressing the following topics: implant surface topography; implant location; occlusal overload; time in function; prosthesis-associated factors (rehabilitation extension, excess of cement and implant-abutment connection); and metal particle release. Although existing data suggests that some implant-based factors may increase the risk of peri-implantitis, the evidence is still limited to consider them a true risk factor for peri-implantitis. In conclusion, further evidences are required to a better understanding of the influence of implant-based factors in the occurrence of peri-implantitis. Large population-based studies including concomitant analyses of implant- and patient-based factors are required to provide strong evidence of a possible association with peri-implantitis in a higher probability. The identification of these factors is essential for the establishment of strategies to prevent peri-implantitis.


Assuntos
Implantes Dentários/efeitos adversos , Peri-Implantite/etiologia , Medição de Risco , Prótese Ancorada no Osso/efeitos adversos , Humanos , Peri-Implantite/prevenção & controle , Fatores de Risco , Propriedades de Superfície , Fatores de Tempo , Falha de Tratamento
8.
Braz Oral Res ; 33(suppl 1): e068, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576952

RESUMO

The objective of this systematic review was to compare the conical internal connection (IC) with the external hexagonal connection (EH) on the occurrence of marginal bone loss (ΔMBL). Different databases were used to carry out the selection of the elected studies. The studies were judged according to the risk of bias as "high", "low" and "unclear" risk. For the meta-analysis we included only studies that could extract the data of ΔMBL, survival rate (SR) and probing depth (PD). No statistically significant differences were found for ΔMBL data at one, three- and five-year survival rates between implant connections (p <0.05), however statistically significant differences were found for PD between EH and IC implants (1-year follow-up) -0.53 [95%CI -0.82 to -0.24, p = 0.0004]. This present systematic review demonstrated that there are no significant differences between IC and EH implants for both ΔMBL and SR at 1, 3 e 5 years after functional loading, although better PD values were observed for implants pertaining to the IC connections. Considering the high heterogeneity, more well-delineated, randomized clinical trials should be conducted.


Assuntos
Perda do Osso Alveolar/etiologia , Dente Suporte/efeitos adversos , Projeto do Implante Dentário-Pivô/efeitos adversos , Implantes Dentários/efeitos adversos , Humanos , Valores de Referência , Medição de Risco , Fatores de Risco , Fatores de Tempo
9.
Braz Oral Res ; 33(suppl 1): e070, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576954

RESUMO

The aim of this review is to summarize the evidence on associations between diabetes mellitus (DM) and complications around dental implants. Electronic database searches of MEDLINE, EMBASE, JBI Database of Systematic Reviews and Implementation Reports, Cochrane Database of Systematic Reviews and the PROSPERO register were performed from 1990 up to and including May 2018, using MeSH terms and other keywords. Systematic reviews and meta-analyses investigating the associations of DM and implant complications (failure, survival, bone loss, peri-implant diseases, and post-surgery infection) were eligible. The quality of the included reviews was determined using the Assessment of Multiple Systematic Reviews Tool 2 (AMSTAR 2). Twelve systematic reviews were included. Implant survival rates ranged from 83.5% to 100%, while implant failure rates varied from 0% to 14.3% for subjects with DM. The three meta-analyses performed for event "implant failure" reported no statistically significant differences between diabetic and non-diabetic subjects. An apparently increased risk of peri-implantitis is reported in patients with DM. According to the AMSTAR 2 classification, 50% of the reviews were classified as being of "critically low", 25% as of "low" and 25% as of "moderate" quality. Evidence indicates high levels of survival and low levels of failure of implants inserted in patients with DM. However, DM was assessed as a whole in the majority of studies and, the actual influence of hyperglycemia on implant survival/failure is still uncertain. DM/hyperglycemia seems to be associated with a high risk of peri-implantitis. However, this conclusion is based on a limited number of systematic reviews.


Assuntos
Complicações do Diabetes/complicações , Peri-Implantite/etiologia , Implantes Dentários/efeitos adversos , Falha de Restauração Dentária , Humanos , Falha de Prótese , Fatores de Risco , Falha de Tratamento
10.
Braz Oral Res ; 33(suppl 1): e071, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576955

RESUMO

The aim of this illustrated review is to present the new strategies and developments to treatment and diagnosis of periimplant diseases. Periimplant disease is a subject of great concern for modern dentistry. The numbers of implant exhibiting biological complications grows as implant dentistry expands thought-out the world. Diagnosis and treatment of those diseases are still controversial and difficult. We present novel treatment for infection control and biological rationale of additional use of guided bone regeneration, with an illustrative explanation of the treatments presented with two cases.


Assuntos
Peri-Implantite/diagnóstico , Peri-Implantite/terapia , Fotoquimioterapia/métodos , Regeneração Óssea , Prótese Ancorada no Osso/efeitos adversos , Implantes Dentários/efeitos adversos , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Reprodutibilidade dos Testes , Resultado do Tratamento
11.
Braz Oral Res ; 33(suppl 1): e073, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576957

RESUMO

Soft tissue defects around dental implants, such as papilla or volume loss, peri-implant recession and alterations of the ridge color and/or texture, lead to esthetic and functional complaints. Treatments of these defects in implants are more demanding than in teeth because peri-implant tissue exhibits different anatomical and histological characteristics. This narrative review discusses the proposed treatments for soft tissue defects around implants in the current literature. Several clinical and pre-clinical studies addressed methods to augment the quantity of the peri-implant keratinized mucosa. Autogenous grafts performed better than soft tissue substitutes in the treatment of soft tissue defects, but there is no clinical consensus on the more appropriate donor area for connective tissue grafts. Treatment for facial volume loss, alterations on the mucosa color or texture and shallow peri-implant recessions are more predictable than deep recessions and sites that present loss of papilla. Correction of peri-implant soft tissue defects may be challenging, especially in areas that exhibit larger defects and interproximal loss. Therefore, the regeneration of soft and hard tissues during implant treatment is important to prevent the occurrence of these alterations.


Assuntos
Perda do Osso Alveolar/terapia , Prótese Ancorada no Osso/efeitos adversos , Interface Osso-Implante , Implantes Dentários/efeitos adversos , Retração Gengival/terapia , Perda do Osso Alveolar/etiologia , Perda do Osso Alveolar/patologia , Interface Osso-Implante/patologia , Face/patologia , Retração Gengival/etiologia , Retração Gengival/patologia , Humanos , Reprodutibilidade dos Testes , Resultado do Tratamento
12.
Braz Oral Res ; 33(suppl 1): e074, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31576958

RESUMO

Most of the literature evaluating dental implants focuses on implant survival, which is a limited proxy for the successful rehabilitation of patients with missing teeth. Success should include not only survival but also lack of mechanical, biological, and esthetics problems. A comprehensive review of local and systemic risk factors prior to implant placement will allow the tailoring of treatment planning and maintenance protocols to the patient's profile in order to achieve longitudinal success of the therapy. This review discusses the role of controlling different risk factors and prevention/treatment of peri-implant mucositis in order to avoid peri-implantitis. Although the literature addressing the topic is still scarce, the existing evidence shows that performing optimal plaque control and regular visits to the dentist seem to be adequate to prevent peri-implant lesions. Due to impossibility of defining a probing depth associate with peri-implant health, radiographic evaluations may be considered in the daily practice. So far, there is a strong evidence linking a past history of periodontal disease to peri-implant lesions, but this is not so evident for other factors including smoking and diabetes. The prevention of biological complications starts even before implant placement and include a broader analysis of the patient risk profile and tailoring the rehabilitation and maintenance protocols accordingly. It should be highlighted that the installation of implants does not modify the patient profile, since it does not modify genetics, microbiology or behavioral habits of any individual.


Assuntos
Interface Osso-Implante , Implantes Dentários/efeitos adversos , Peri-Implantite/prevenção & controle , Periodontite/prevenção & controle , Estomatite/prevenção & controle , Interface Osso-Implante/diagnóstico por imagem , Placa Dentária/prevenção & controle , Humanos , Higiene Bucal , Peri-Implantite/etiologia , Índice Periodontal , Periodontite/etiologia , Radiografia Dentária , Fatores de Risco , Estomatite/etiologia
14.
Middle East Afr J Ophthalmol ; 26(3): 175-177, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31619908

RESUMO

A 79-year-old man presented to the ophthalmology clinic with acute-onset left orbital and periorbital swelling, 6 days following surgery to revise a zygomatic implant to anchor his dentures. On evaluation, there was left eye proptosis with ipsilateral facial crepitus. Emphysema was confirmed on computed tomography. With visual function and motility remaining intact, he was observed without intervention. Within 2 weeks, his evaluation returned to baseline. Periorbital emphysema is a rare complication of dental procedures. Awareness of this potential complication enables timely diagnosis and avoidance of unnecessary therapy.


Assuntos
Implantes Dentários/efeitos adversos , Enfisema/diagnóstico por imagem , Celulite Orbitária/diagnóstico por imagem , Doenças Orbitárias/diagnóstico por imagem , Idoso , Diagnóstico Diferencial , Enfisema/etiologia , Exoftalmia , Humanos , Masculino , Doenças Orbitárias/etiologia , Tomografia Computadorizada por Raios X , Zigoma/cirurgia
15.
J Appl Oral Sci ; 27: e20180476, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31596364

RESUMO

OBJECTIVES: Miniscrew has been frequently used, considering that anchorage control is a critical point in orthodontic treatment, and its failure, the main adverse problem. Using two groups of stable (successful) and unstable (failed) mini-implants, this in vivo study aimed to quantify proinflammatory cytokines IL-1 α, IL-6, IL-17, and TNF-α and osteoclastogenesis marker RANK, RANKL, and OPG in gingival tissue, using the real-time polymerase chain reaction technique. METHODOLOGY: Thirteen patients of both sexes (11-49 years old) under orthodontic treatment were selected, obtaining 11 successful and 7 failed mini-implants. The mini-implants were placed and removed by the same surgeon, in both jaws. The mean time of permanence in the mouth was 29.4 months for successful and 7.6 months for failed mini-implants. At removal time, peri-mini-implant gingival tissue samples were collected and processed for quantification of the proinflammatory cytokines and osteoclastogenesis markers. Nonparametric Wilcoxon rank-sum test considering the clusters and Kruskal-Wallis test were used for statistical analysis (α=0.05). RESULTS: No significant difference (p>0.05) was observed between the groups for either quantification of cytokines or osteoclastogenesis markers, except for IL-6 (p<0.05). CONCLUSIONS: It may be concluded that the expression of IL-1α, IL-17, TNF-α, RANK, RANKL, and OPG in peri-implant gingival tissue were not determinant for mini-implant stability loss, but the higher IL-6 expression could be associated with mini-implant failure.


Assuntos
Citocinas/análise , Implantes Dentários/efeitos adversos , Gengivite/patologia , Procedimentos de Ancoragem Ortodôntica/efeitos adversos , Osteogênese/fisiologia , Peri-Implantite/patologia , Adolescente , Adulto , Perda do Osso Alveolar , Biomarcadores/análise , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteoprotegerina/análise , Reação em Cadeia da Polimerase em Tempo Real , Valores de Referência , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
16.
Genes (Basel) ; 10(9)2019 09 14.
Artigo em Inglês | MEDLINE | ID: mdl-31540037

RESUMO

BACKGROUND: Sometimes dental implants seem to be the only therapeutic alternative for the oral rehabilitation of patients with Down syndrome, given that they usually lose all their teeth early due to suffering aggressive periodontitis and they do not usually have the skills required to wear removable prostheses. However, the evolution of dental implants in these patients shows very adverse results. It is possible that basal genetic alterations, or at least some characteristics of these, may underlie these clinical results. The metabolic pathway of metallothioneins, molecules with an important influence on bone metabolism, could be one of the said alterations. AIMS: To determine whether the expression of metallothioneins (MTs) and their metabolic pathway may be identified and related to the periodontitis and lack of osseointegration of dental implants in Down syndrome patients. MATERIALS AND METHODS: Retrospective study of cases and controls by comparing patients with Down syndrome, periodontal disease, and implant failure (four patients, test group) with patients with Down syndrome, without periodontal disease, and without implant failure after two years of following (seven patients, control group), by extracting peripheral blood at the time of the dental examination to extract RNA and its subsequent processing in relation to gene expression of the metabolic pathway of metallothioneins. RESULTS: The results identified low expression in the group of patients with periodontal disease and implant failure of genes MT1E, MT1H, MT1X, MT1A, MT1B, MT1C, MT1L, MT2A, MT1M, and MT1G. CONCLUSIONS: The low MT1 and MT2 gene expression seems to be related to the onset of periodontal disease and implant rejection in Down syndrome patients, although more data are required to confirm whether this relationship is due to one of the two conditions, to both independently, or to the two jointly-this last option being indicated by our current study.


Assuntos
Implantes Dentários/efeitos adversos , Síndrome de Down/complicações , Metalotioneína/metabolismo , Peri-Implantite/metabolismo , Falha de Prótese , Adulto , Feminino , Humanos , Masculino , Metalotioneína/genética , Osseointegração , Peri-Implantite/complicações , Peri-Implantite/etiologia
17.
J Mater Sci Mater Med ; 30(9): 97, 2019 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-31440845

RESUMO

Sinus elevation is a common procedure to increase bone volume in the atrophic maxilla to allow placement of dental implants. Autogenous bone is the gold standard but is limited in quantity and causes morbidity at the donor site. ß-TCP is a synthetic biomaterial commonly used in that purpose. It appears to induce a poor inflammatory response. This study aimed to evaluate the degree of edema of the sinus mucosa after sinus lift surgery according to the type of biomaterial. Forty sinuses (20 patients) were included retrospectively and divided into 2 groups according to the biomaterial that was used: synthetic biomaterial (BTCP group), natural bone (BONE group). A control group (CTRL group) was constituted by the non-grafted maxillary sinuses. Twelve measurements per sinus were realized on pre- and post-operative computed tomography and averaged to provide the sinus membrane thickness value (SM.Th). SM.Th was thicker post-operatively in the BTCP and BONE groups in comparison with the CTRL group and in comparison with pre-operative measurements. No difference was found post operatively between the BTCP and BONE groups. We found that a synthetic biomaterial (ß-TCP) induced the same degree of edema, and thus of inflammation, as natural bone. It constitutes therefore an interesting alternative to autogenous bone for maxillary sinus lifts.


Assuntos
Substitutos Ósseos/efeitos adversos , Transplante Ósseo/efeitos adversos , Fosfatos de Cálcio/efeitos adversos , Fosfatos de Cálcio/química , Sinusite Maxilar/etiologia , Levantamento do Assoalho do Seio Maxilar/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Materiais Biocompatíveis/efeitos adversos , Substitutos Ósseos/química , Transplante Ósseo/métodos , Implantação Dentária Endo-Óssea/efeitos adversos , Implantação Dentária Endo-Óssea/métodos , Implantes Dentários/efeitos adversos , Feminino , Humanos , Inflamação/etiologia , Inflamação/patologia , Masculino , Seio Maxilar/efeitos dos fármacos , Seio Maxilar/patologia , Sinusite Maxilar/patologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Levantamento do Assoalho do Seio Maxilar/métodos
18.
Gene ; 719: 144080, 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31454541

RESUMO

Trigeminal neuropathic pain is seen as a huge clinical challenge. Although numerous drugs have been developed to treat the condition, some patients have shown intolerance to the drugs and thus continue to suffer. In the present study, a rat model of trigeminal neuropathic pain was established using incorrectly positioned dental implants, which had various manifestations that were similar to human trigeminal neuropathic pain. Using this model, we investigated the differential regulation of JAK2 and PTEN. Firstly, we examined the expression of JAK2 and PTEN in the medullary dorsal horn. After inhibiting JAK2/PTEN, we evaluated nociception-related behavioral alterations. The rat models were established by replacing the left lower second molar with a mini dental implant. Immunoblot assay and immunofluorescence experiments indicated high expression of JAK2 and PTEN in medullary dorsal horn after the nerve injury, which attained plateau levels on post-operative day (POD) 5-10 and 10-20. Administration of adenovirus-shRNA-JAK2 on POD 1 reduced mechanical allodynia and downstream STAT activation. Meanwhile, the administration of adenovirus-shRNA-PTEN on POD 1 attenuated mechanical allodynia while upregulating AKT. In addition to postoperative JAK2 and PTEN activation, dexmedetomidine treatment (10 mg/kg) also modulated the downstream sensors of these signaling molecules. These data suggest that JAK2 and PTEN are pivotal to the development of trigeminal neuropathic pain, and that JAK2 and PTEN suppression alleviates the neuropathic pain.


Assuntos
Técnicas de Silenciamento de Genes , Janus Quinase 2/genética , Neuralgia/diagnóstico , PTEN Fosfo-Hidrolase/genética , Neuralgia do Trigêmeo/genética , Animais , Implantes Dentários/efeitos adversos , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Dexmedetomidina/administração & dosagem , Dexmedetomidina/uso terapêutico , Modelos Animais de Doenças , Hiperalgesia/tratamento farmacológico , Hiperalgesia/etiologia , Janus Quinase 2/antagonistas & inibidores , Masculino , Neuralgia/genética , PTEN Fosfo-Hidrolase/antagonistas & inibidores , Medição da Dor , Ratos , Ratos Sprague-Dawley
19.
Biomed Res Int ; 2019: 6092018, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31467901

RESUMO

Recent data indicates limited awareness and compliance on infection prevention procedures by dental offices and by dental laboratories. Guidelines for infection prevention in dentistry have been published by Centres for Disease Control and Prevention since 2003; the section "IX-Special consideration" includes a subsection concerning the prevention in dental laboratories, but it has not been modernised in later versions to fit the needs of traditional and computer-aided technology. Traditional techniques required disinfecting items (impression, chewing waxes, and appliances) with well-suited products, which are also chosen for limiting impression changes or appliance deterioration. Effective procedures are available with difficulties. Some of these contain irritant or non-eco-friendly disinfectants. The transport of impression, to dental laboratories, is often delayed with limited precautions for limiting cross-infection. Gypsum casts are frequently contaminated mainly by bacteria and their antibiotic-resistant strains and even stored for long periods during dental implant supported restoration and orthodontic therapy, becoming a hidden source of infection. Nowadays, computer-aided design/computer-aided manufacturing technology seems to be an interesting way to promote both business and safety, being more comfortable for patients and more accurate than traditional technology. A further advantage is easier infection prevention since, for the most part, mainly digital impression and casts are not a source of cross-infection and the transport of contaminated items is reduced and limited to try-in stages. Nevertheless, a peculiar feature is that a digital electronic file is of course unalterable, but may be ruined by a computer virus. Additionally, the reconditioning of scanner tips is determinant for the optical characteristics and long term use of the scanner, but information for its reconditioning from producers is often limited. This study focuses on some critical points including (a) insufficient guidelines, (b) choice of proper procedure for scanner reconditioning, and (c) data protection in relation to patient privacy.


Assuntos
Projeto Auxiliado por Computador , Implantes Dentários/efeitos adversos , /terapia , Implantes Dentários/microbiologia , Materiais para Moldagem Odontológica/efeitos adversos , Técnica de Moldagem Odontológica/efeitos adversos , Odontologia/tendências , Humanos , /microbiologia
20.
Cient. dent. (Ed. impr.) ; 16(2): 93-98, mayo-ago. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-183718

RESUMO

Introducción: El Granuloma periférico de células gigantes (GPCG) es una lesión exofítica poco frecuente de la cavidad oral, cuya aparición se encuentra generalmente asociada al diente natural y cuya etiología se relaciona, entre otros factores, con el efecto crónico en el tiempo de diversos irritantes locales. Con el creciente uso de los implantes dentales, se ha observado la aparición de este tipo de lesiones en la mucosa periimplantaria, lo que obliga a estudiar y comprender su etiología y evolución en función de garantizar la longevidad de este tipo de rehabilitaciones. Caso clínico: Se presenta el caso de una paciente mujer de 41 años de edad, sin antecedentes médicos de interés, remitida al servicio de Cirugía Bucal del Hospital Virgen de la Paloma, la cual presenta una tumoración de base sésil asociada a un implante en posición de 47, de 1,2x0,6 cm, indolora, de consistencia firme y no desplazable con coloración congestiva. Se llevo a cabo un tratamiento de exéresis total de la lesión, remitiendo la pieza a estudio histopatológico, tras el cual se obtuvo el diagnóstico de GPCG. Conclusiones: Es de vital importancia mantener un control exhaustivo de los diversos factores locales que pueden identificarse como irritantes para los tejidos periimplantarios, como es el caso de una higiene oral deficiente, entre otros, con el fin de prevenir la aparición de lesiones que pudieran comprometer la supervivencia y éxito de los implantes a largo plazo


Introduction: The peripheral giant cell granuloma (GPCG) is a rare exophytic lesion of the oral cavity, whose appearance is usually associated with the natural tooth and whose etiology is related, among other factors, to the chronic effect over time of various local irritants. With the increasing use of dental implants, the appearance of this type of lesions in the peri-implant mucosa has been observed, which requires studying and understanding its etiology and evolution in order to guarantee the longevity of this type of rehabilitation. Clinical case: We present the case of a 41-year-old female patient, with no medical history of interest, referred to the Oral Surgery Department of the Hospital Virgen de la Paloma, which presents a sessile base tumor associated with an implant in position 47, of 1.2x0.6 cm, painless, firm consistency and nondisplaceable with congestive coloring. A total exeresis treatment of the lesion was carried out, sending the piece to histopathological study, after which the diagnosis of GPCG was obtained. Conclusions: It is vital to maintain an exhaustive control of the various local factors that can be identified as irritants for peri-implant tissues, such as poor oral hygiene, among others, in order to prevent the appearance of injuries that could compromise survival and success of long-term implants


Assuntos
Humanos , Feminino , Adulto , Implantes Dentários/efeitos adversos , Granuloma de Células Gigantes/diagnóstico por imagem , Granuloma de Células Gigantes/cirurgia , Prognóstico , Cirurgia Bucal , Granuloma de Células Gigantes/patologia
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