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2.
Int J Mol Sci ; 21(7)2020 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-32276523

RESUMO

It is widely known that glomerulonephritis (GN) often develops after the curing of an infection, a typical example of which is GN in children following streptococcal infections (poststreptococcal acute glomerulonephritis; PSAGN). On the other hand, the term "infection-related glomerulonephritis (IRGN)" has recently been proposed, because infections are usually ongoing at the time of GN onset in adult patients, particularly in older patients with comorbidities. However, there has been no specific diagnostic biomarker for IRGN, and diagnosis is based on the collection of several clinical and pathological findings and the exclusion of differential diagnoses. Nephritis-associated plasmin receptor (NAPlr) was originally isolated from the cytoplasmic fraction of group A streptococcus as a candidate nephritogenic protein for PSAGN and was found to be the same molecule as streptococcal glyceraldehyde-3-phosphate dehydrogenase and plasmin receptor. NAPlr deposition and related plasmin activity were observed with a similar distribution pattern in the glomeruli of patients with PSAGN. However, glomerular NAPlr deposition and plasmin activity could be observed not only in patients with PSAGN but also in patients with other glomerular diseases, in whom a preceding streptococcal infection was suggested. Furthermore, such glomerular staining patterns have been demonstrated in patients with IRGN induced by bacteria other than streptococci. This review discusses the recent advances in our understanding of the pathogenesis of bacterial IRGN, which is characterized by NAPlr and plasmin as key biomarkers.


Assuntos
Fibrinolisina/análise , Glomerulonefrite/diagnóstico , Receptores de Peptídeos/análise , Infecções Estreptocócicas/complicações , Infecções Bacterianas/complicações , Biomarcadores/análise , Glomerulonefrite/etiologia , Humanos , Glomérulos Renais/metabolismo
3.
PLoS One ; 15(2): e0228488, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32017787

RESUMO

BACKGROUND: Streptococcus suis (S.suis) is an emerging zoonosis disease with a high prevalence in Southeast Asia. There are over 1,500 cases reported globally in which majority of cases are from Thailand followed by Vietnam. The disease leads to meningitis in human with sensorineural hearing loss (SNHL) as the most common complication suffered by the patients. Early diagnosis and treatment is important to prevent severe neurological complication. In this study, we aim to develop an easy-to-use risk score to promote early diagnosis and detection of S.suis in patients who potentially develop hearing loss. METHODS: Data from a retrospective review of 13-year S.suis patient records in a tertiary hospital in Chiang Mai, Northern, Thailand was obtained. Univariate and multivariate logistic regressions were employed to develop a predictive model. The clinical risk score was constructed from the coefficients of significant predictors. Area under the receiver operator characteristic curve (AuROC) was identified to verify the model discriminative performance. Bootstrap technique with 1000-fold bootstrapping was used for internal validation. KEY RESULTS: Among 133 patients, the incidence of hearing loss was 31.6% (n = 42). Significant predictors for S. suis hearing loss were meningitis, raw pork consumption, and vertigo. The predictive score ranged from 0-4 and correctly classified 81.95% patients as being at risk of S.suis hearing loss. The model showed good power of prediction (AuROC: 0.859; 95%CI 0.785-0.933) and calibration (AuROC: 0.860; 95%CI 0.716-0.953). CONCLUSIONS: To our best knowledge, this is the first risk scoring system development for S.suis hearing loss. We identified meningitis, raw pork consumption and vertigo as the main risk factors of S.suis hearing loss. Future studies are needed to optimize the developed scoring system and investigate its external validity before recommendation for use in clinical practice.


Assuntos
Perda Auditiva Neurossensorial/epidemiologia , Meningites Bacterianas/complicações , Infecções Estreptocócicas/complicações , Streptococcus suis/patogenicidade , Vertigem/epidemiologia , Adulto , Idoso , Área Sob a Curva , Feminino , Perda Auditiva Neurossensorial/microbiologia , Humanos , Incidência , Modelos Logísticos , Masculino , Meningites Bacterianas/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Medição de Risco , Infecções Estreptocócicas/epidemiologia , Centros de Atenção Terciária , Tailândia/epidemiologia , Vertigem/complicações
4.
Nat Rev Nephrol ; 16(1): 32-50, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31399725

RESUMO

For over a century, acute 'post-streptococcal glomerulonephritis' (APSGN) was the prototypical form of bacterial infection-associated glomerulonephritis, typically occurring after resolution of infection and a distinct infection-free latent period. Other less common forms of infection-associated glomerulonephritides resulted from persistent bacteraemia in association with subacute bacterial endocarditis and shunt nephritis. However, a major paradigm shift in the epidemiology and bacteriology of infection-associated glomerulonephritides has occurred over the past few decades. The incidence of APSGN has sharply declined in the Western world, whereas the number of Staphylococcus infection-associated glomerulonephritis (SAGN) cases increased owing to a surge in drug-resistant Staphylococcus aureus infections, both in the hospital and community settings. These Staphylococcus infections range from superficial skin infections to deep-seated invasive infections such as endocarditis, which is on the rise among young adults owing to the ongoing intravenous drug use epidemic. SAGN is markedly different from APSGN in terms of its demographic profile, temporal association with active infection and disease outcomes. The diagnosis and management of SAGN is challenging because of the lack of unique histological features, the frequently occult nature of the underlying infection and the older age and co-morbidities in the affected patients. The emergence of multi-drug-resistant bacterial strains further complicates patient treatment.


Assuntos
Endocardite Bacteriana/epidemiologia , Glomerulonefrite/epidemiologia , Infecções Estafilocócicas/epidemiologia , Infecções Estreptocócicas/epidemiologia , Distribuição por Idade , Antibacterianos/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Endocardite Bacteriana/complicações , Endocardite Bacteriana/terapia , Hidratação , Glomerulonefrite/etiologia , Glomerulonefrite/microbiologia , Glomerulonefrite/terapia , Humanos , Imunossupressores/uso terapêutico , Rim/patologia , Staphylococcus aureus Resistente à Meticilina , Infecções Estafilocócicas/complicações , Infecções Estafilocócicas/microbiologia , Infecções Estafilocócicas/terapia , Staphylococcus aureus , Staphylococcus epidermidis , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/terapia , Streptococcus pyogenes , Abuso de Substâncias por Via Intravenosa/epidemiologia , Fatores de Tempo
5.
Int J Mol Sci ; 21(1)2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31861863

RESUMO

Human ß defensin-3-C15, an epithelium-derived cationic peptide that has antibacterial/antifungal and immuno-regulatory properties, is getting attention as potential therapeutic agent in endodontics. This study aimed to investigate if synthetic human ß defensin-3-C15 (HBD3-C15) peptides could inhibit inflammatory responses in human dental pulp cells (hDPCs), which had been induced by gram-positive endodontic pathogen. hDPC explant cultures were stimulated with Streptococcus gordonii lipoprotein extracts for 24 h to induce expression of pro-inflammatory mediators. The cells were then treated with either HBD3-C15 (50 µg/mL) or calcium hydroxide (CH, 100 µg/mL) as control for seven days, to assess their anti-inflammatory effects. Quantitative RT-PCR analyses and multiplex assays showed that S. gordonii lipoprotein induced the inflammatory reaction in hDPCs. There was a significant reduction of IL-8 and MCP-1 within 24 h of treatment with either CH or HBD3-C15 (p < 0.05), which was sustained over 1 week of treatment. Alleviation of inflammation in both medications was related to COX-2 expression and PGE2 secretion (p < 0.05), rather than TLR2 changes (p > 0.05). These findings demonstrate comparable effects of CH and HDB3-C15 as therapeutic agents for inflamed hDPCs.


Assuntos
Anti-Inflamatórios/farmacologia , Lipoproteínas/imunologia , Infecções Estreptocócicas/imunologia , Streptococcus gordonii/imunologia , beta-Defensinas/farmacologia , Anti-Inflamatórios/síntese química , Células Cultivadas , Polpa Dentária/citologia , Polpa Dentária/efeitos dos fármacos , Polpa Dentária/imunologia , Humanos , Inflamação/tratamento farmacológico , Inflamação/etiologia , Inflamação/imunologia , Modelos Moleculares , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/tratamento farmacológico , beta-Defensinas/síntese química
6.
BMJ Case Rep ; 12(12)2019 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-31857289

RESUMO

A 26-year-old man who was previously well presented to the emergency in septic shock. He had a preceding history of fever, right upper abdominal pain and jaundice. On examination, there was tenderness over the right hypochondrium and epigastrium, without features of generalised peritonitis. His blood tests were suggestive of sepsis with deranged liver function tests. CT scan of the abdomen showed multiples abscesses in various segments of the liver and a thrombus in the inferior venacava, without any other intraabdominal focus of infection. The abscess was aspirated under sonographic guidance, and the cultures grew Streptococcus constellatus species of S. milleri group (SMG). He received crystalline penicillin, based on culture sensitivity and underwent drainage of the abscess. There was a clinical improvement and he was subsequently discharged in a stable condition. On 3 months follow-up, there was a complete resolution of the liver abscess and normalisation of the liver function tests.


Assuntos
Abscesso Hepático Piogênico/diagnóstico , Infecções Estreptocócicas/diagnóstico , Streptococcus constellatus/isolamento & purificação , Dor Abdominal/etiologia , Adulto , Antibacterianos/uso terapêutico , Terapia Combinada , Diagnóstico Diferencial , Drenagem , Febre/etiologia , Humanos , Icterícia/etiologia , Abscesso Hepático Piogênico/complicações , Abscesso Hepático Piogênico/diagnóstico por imagem , Abscesso Hepático Piogênico/terapia , Masculino , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/diagnóstico por imagem , Infecções Estreptocócicas/terapia , Tomografia Computadorizada por Raios X
7.
Medicine (Baltimore) ; 98(48): e18156, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31770258

RESUMO

RATIONALE: Streptococcus anginosus mostly colonizes the digestive and genitourinary system, including the oropharyngeal region. It commonly causes invasive pyogenic infection, but less likely causes infective endocarditis (IE). PATIENT CONCERNS: An 18-year-old woman who had an underlying mitral valve prolapse without mitral regurgitation presented to our hospital with low-grade fever, left leg weakness, and left abdominal pain. She was diagnosed with brain infarction and microabscess as well as IE. The patient totally recovered after the 6-week course of intravenous antibiotics. DIAGNOSIS: Brain magnetic resonance imaging revealed brain infarction and microabscess. Abdominal computed tomography revealed splenic and left renal infarction. Three sets of blood culture were positive for S anginosus. Transthoracic echocardiogram identified mitral valve prolapse with moderate eccentric mitral valve regurgitation, and a 0.3 × 0.6-cm vegetation was found on the left mitral valve. All of these results meet the modified Duke criteria. INTERVENTIONS: The abdominal pain and left leg weakness were improving after 2 weeks of intravenous antibiotics treatment. No neurological sequelae were noted after completing the 6-week course of medical treatment. OUTCOMES: The patient was successfully treated and discharged after completing the 6-week intravenous antibiotics treatment. LESSONS: IE should be considered in young patients with native valve disease who have prolonged fever. Though S anginosus commonly causes invasive pyogenic infection, patients with native valve disease should be checked for IE.


Assuntos
Antibacterianos/administração & dosagem , Abscesso Encefálico , Infarto Encefálico , Endocardite , Prolapso da Valva Mitral , Infecções Estreptocócicas , Streptococcus anginosus/isolamento & purificação , Administração Intravenosa , Adolescente , Abscesso Encefálico/diagnóstico por imagem , Abscesso Encefálico/tratamento farmacológico , Abscesso Encefálico/etiologia , Infarto Encefálico/diagnóstico por imagem , Infarto Encefálico/etiologia , Ecocardiografia/métodos , Endocardite/complicações , Endocardite/diagnóstico , Endocardite/tratamento farmacológico , Endocardite/microbiologia , Feminino , Humanos , Insuficiência da Valva Mitral/diagnóstico , Insuficiência da Valva Mitral/etiologia , Prolapso da Valva Mitral/complicações , Prolapso da Valva Mitral/diagnóstico por imagem , Recuperação de Função Fisiológica , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/diagnóstico , Infecções Estreptocócicas/tratamento farmacológico , Resultado do Tratamento
8.
Orv Hetil ; 160(48): 1887-1893, 2019 Dec.
Artigo em Húngaro | MEDLINE | ID: mdl-31760775

RESUMO

Streptococcal toxic shock syndrome (STSS) is a hyperacute, life-threatening illness, a complication of invasive streptococcal (mostly group A, rarely groups B, G or C) infection. There is no portal of entry (skin, vagina, pharynx) in nearly half of the STSS cases. The initial signs and symptoms (fever, flu-like complaints, hypotension) are scarce and aspecific, but because of its rapid progression and poor prognosis, early high level of suspicion is necessary. Management has 3 crucial points: initiation of anti-streptococcal regimen (and intravenous immunoglobulin in some cases), aggressive intensive care support of multi-organ failure, and surgical control of the infective source. In this article, we present a case of a patient succumbing to streptococcal toxic shock syndrome which was preceded by primary S. pyogenes bacteremia, and review the key points of this potentially fatal disease for practising clinicians. Orv Hetil. 2019; 160(48): 1887-1893.


Assuntos
Choque Séptico/microbiologia , Infecções Estreptocócicas/diagnóstico , Streptococcus pyogenes/isolamento & purificação , Evolução Fatal , Feminino , Humanos , Pessoa de Meia-Idade , Choque Séptico/complicações , Infecções Estreptocócicas/complicações
9.
J Am Podiatr Med Assoc ; 109(4): 305-307, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31762305

RESUMO

Streptococcus anginosus (SAG) is a known human pathogen and member of the Streptococcus milleri group. SAG is a known bacterial cause of soft-tissue abscesses and bacteremia and is an increasingly prevalent pathogen in infections in patients with cystic fibrosis. We describe a rare case of SAG as an infectious agent in a case of nonclostridial myonecrosis with soft-tissue emphysema. This is the only case found in the literature of SAG cultured as a pure isolate in this type of infection and was associated with a prolonged course of treatment in an otherwise healthy patient.


Assuntos
Pé Diabético/complicações , Gangrena Gasosa/microbiologia , Infecções Estreptocócicas/complicações , Streptococcus anginosus/isolamento & purificação , Amputação , Pé Diabético/microbiologia , Gangrena Gasosa/etiologia , Gangrena Gasosa/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Streptococcus anginosus/patogenicidade
11.
Medicine (Baltimore) ; 98(40): e17444, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577768

RESUMO

RATIONALE: Canaliculitis is a frequently overlooked and misdiagnosed disease. Concurrent corneal ulceration with canaliculitis is uncommon. We report such a case. PATIENT CONCERNS: An 87-year-old woman complained of swelling and pain of the right eye after acute angle closure glaucoma attack. Slit-lamp examination was compatible with the features of infectious keratitis, and the cultures from corneal scrapings grew Streptococcus anginosus later. Hourly topical vancomycin (25 mg/ml) was instilled, then the corneal ulceration improved initially but became stationary after 1-week treatment. DIAGNOSIS: Discharge from the upper punctum was noted subsequently and canalicular concretions were found through curettage. The cultures from canalicular discharge and concretions also revealed the presence of S. anginosus. Thus, infectious keratitis secondary to canaliculitis was diagnosed. INTERVENTIONS: Canaliculotomy was performed to remove the large concretion and vancomycin was injected locally. OUTCOMES: The corneal ulceration resolved after canaliculitis was appropriately treated. LESSONS: Canaliculitis could be a reservoir for organisms that may make compromised corneas liable to infections. Only the appropriate diagnosis and aggressive treatment of canaliculitis leads to the eradication of associated corneal infections.


Assuntos
Canaliculite/complicações , Úlcera da Córnea/microbiologia , Infecções Oculares Bacterianas/complicações , Infecções Estreptocócicas/complicações , Streptococcus anginosus , Idoso de 80 Anos ou mais , Canaliculite/diagnóstico , Canaliculite/terapia , Úlcera da Córnea/diagnóstico , Úlcera da Córnea/terapia , Infecções Oculares Bacterianas/diagnóstico , Infecções Oculares Bacterianas/terapia , Feminino , Humanos , Infecções Estreptocócicas/diagnóstico , Infecções Estreptocócicas/terapia
12.
Vestn Otorinolaringol ; 84(4): 61-66, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31579061

RESUMO

Here, we performed the comprehensive review of the peer-reviewed literature of the effect of chronic foci of streptococcal infection on the course of skin psoriasis, as well as an assessment of the effectiveness of tonsillectomy on the course of this pathology. A PubMed, Web of Science and Google Scholar search were performed with the keywords 'psoriasis' AND 'tonsillectomy' OR 'tonsillitis' OR 'streptococcal infection'. The reviewers identified and evaluated 197 reports published prior to August 2018, of which 153 were excluded from further analysis after review of titles and/or abstracts including four duplicate studies from the same authors in the same patient groups. In total, 44 reports were used and included in the review (including original studies, a description of clinical cases, literature reviews). Analysis of the original studies showed that the effectiveness of tonsillectomy in patients with psoriasis is from 11.4 to 78.6%. Among clinical cases, the rate was 20-100%. We did not conduct a meta-analysis and use the statistical methods because of the heterogeneity of the data. Data were analysed using a descriptive approach. Most studies came from Russia, USA, Japan. However, multiple limitations in the studies do not allow final conclusions about the effectiveness of tonsillectomy in patients with psoriasis.


Assuntos
Psoríase , Infecções Estreptocócicas , Tonsilectomia , Tonsilite , Humanos , Psoríase/complicações , Psoríase/cirurgia , Federação Russa , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/cirurgia , Tonsilite/complicações , Tonsilite/cirurgia
13.
Rev Assoc Med Bras (1992) ; 65(9): 1151-1155, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31618329

RESUMO

This report describes the post-bariatric-surgery evolution of an obese patient who had low adherence to the diet and micronutrient supplementation. Four years after two bariatric surgeries, the patient was admitted due to transient loss of consciousness, slow thinking, anasarca, severe hypoalbuminemia, in addition to vitamin and mineral deficiencies. She had subcutaneous foot abscess but did not present fever. Received antibiotics, vitamins A, D, B12, thiamine, calcium, and parenteral nutrition. After hospitalization (twenty-eight days), there was a significant body weight reduction probably due to the disappearance of clinical anasarca. Parenteral nutrition was suspended after twenty-five days, and the oral diet was kept fractional. After hospitalization (weekly outpatient care), there was a gradual laboratory data improvement, which was now close to the reference values. Such outcome shows the need for specialized care in preventing and treating nutritional complications after bariatric surgeries as well as clinical manifestations of infection in previously undernourished patients.


Assuntos
Cirurgia Bariátrica , Desnutrição Proteico-Calórica/complicações , Infecções Estreptocócicas/complicações , Adulto , Deficiência de Vitaminas/complicações , Deficiência de Vitaminas/terapia , Cirurgia Bariátrica/efeitos adversos , Feminino , Humanos , Nutrição Parenteral , Complicações Pós-Operatórias , Desnutrição Aguda Grave/complicações , Desnutrição Aguda Grave/etiologia , Desnutrição Aguda Grave/terapia , Cooperação e Adesão ao Tratamento
15.
Am J Case Rep ; 20: 1387-1393, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31541072

RESUMO

BACKGROUND Erythroderma is an exfoliative dermatitis that manifests as generalized erythema and scaling that involves 90% of the body surface. If untreated, erythroderma can be fatal because of its metabolic burden and risk of secondary infections. CASE REPORT The patient was a 56-year-old male with prior rash attributed to group A Streptococcal cellulitis and discharged on Augmentin, Clindamycin with hydrocortisone cream, and Bactrim, but he had been noncompliant. He was admitted again for rash involving the face, torso, and extremities characterized by diffuse, desquamative, dry scales in morbilliform pattern. The patient was septic with Staphylococcus aureus bacteremia and compromised skin barrier. He was started on vancomycin and switched to Cefazolin IV due to concern for drug reaction. Autoimmune workup included antibodies for anti-Jo-1, anti-dsDNA, anti-centromere, and ANCA. However, only antinuclear antibody and scleroderma antibody were positive. Given the unclear workup results and lack of response to antibiotics, the patient was started on prednisone 60 mg PO and topical Triamcinolone 0.1% cream. A skin biopsy revealed psoriasiform hyperplasia with atypical T cell infiltrate and eosinophils, but negative for T cell gene rearrangement. The rash resolved after day 12 of application of topical Triamcinolone. CONCLUSIONS This case is unique in terms of the rarity of erythroderma and the diagnostic challenge given confounding factors such as noncompliance and drug reaction. Serious causes, such as SLE and cutaneous T cell lymphoma, were ruled out. Fortunately, the rash responded well to steroids; however, given the adverse effects of long-term use of topical steroids, the patient will need follow up with Dermatology.


Assuntos
Dermatite Esfoliativa/diagnóstico , Eosinofilia/etiologia , Sepse/microbiologia , Administração Tópica , Celulite (Flegmão)/microbiologia , Dermatite Esfoliativa/tratamento farmacológico , Glucocorticoides/uso terapêutico , Humanos , Masculino , Adesão à Medicação , Pessoa de Meia-Idade , Infecções Estafilocócicas/complicações , Infecções Estreptocócicas/complicações , Streptococcus pyogenes , Triancinolona/uso terapêutico
16.
J Pak Med Assoc ; 69(9): 1383-1384, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31511731

RESUMO

Aggregatibacter aphrophilus and Beta haemolytic Streptococci Lancefield group F are part of the normal oral flora and are known to cause endocarditis, sinusitis, empyema, meningitis and septic arthritis. They are now emerging as a cause of brain abscess particularly in patients with congenital heart diseases. We report a case of a 10-year-old boy with Tetralogy of Fallot (TOF), who presented with fever, headache and drowsiness. Culture yielded the growth of Aggregatibacter aphrophilus and Beta hemolytic streptococci Lancefield group F. He became clinically stable after treatment with ceftriaxone.


Assuntos
Abscesso Encefálico/complicações , Coinfecção/complicações , Infecções por Pasteurellaceae/complicações , Infecções Estreptocócicas/complicações , Tetralogia de Fallot/complicações , Aggregatibacter aphrophilus , Antibacterianos/uso terapêutico , Abscesso Encefálico/microbiologia , Abscesso Encefálico/terapia , Ceftriaxona/uso terapêutico , Criança , Coinfecção/microbiologia , Coinfecção/terapia , Craniotomia , Técnicas de Cultura , Humanos , Masculino , Infecções por Pasteurellaceae/microbiologia , Infecções por Pasteurellaceae/terapia , Infecções Estreptocócicas/microbiologia , Infecções Estreptocócicas/terapia , Streptococcus milleri (Grupo) , Tomografia Computadorizada por Raios X
17.
BMJ Case Rep ; 12(8)2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31439551

RESUMO

A 58-year-old man presented with necrotising fasciitis and septic shock requiring urgent surgical debridement. Idarucizumab was used preoperatively to reverse the effects of dabigatran, which he was taking for chronic atrial fibrillation. He developed multiorgan failure including an oliguric acute kidney injury and was given continuous venovenous haemodiafiltration. Adjunctive intravenous immunoglobulin therapy was used in addition to his antibiotic therapy for necrotising fasciitis. Significant clinical and laboratory coagulopathy continued for over 12 days with evidence of a persistent dabigatran effect. Here, we discuss the potential impact of the immunoglobulin therapy, the patient's weight on the degree of redistribution of dabigatran seen and the oliguria in the context of an acute kidney injury on the apparent lack of the effectiveness of idarucizumab.


Assuntos
Antitrombinas/efeitos adversos , Dabigatrana/efeitos adversos , Fasciite Necrosante/diagnóstico , Hemorragia Gastrointestinal/diagnóstico , Choque Séptico/diagnóstico , Infecções Estreptocócicas/diagnóstico , Anticorpos Monoclonais Humanizados/administração & dosagem , Anticorpos Monoclonais Humanizados/uso terapêutico , Fibrilação Atrial/tratamento farmacológico , Diagnóstico Diferencial , Fasciite Necrosante/complicações , Fasciite Necrosante/tratamento farmacológico , Hemorragia Gastrointestinal/induzido quimicamente , Humanos , Perna (Membro) , Masculino , Pessoa de Meia-Idade , Diálise Renal , Choque Séptico/complicações , Choque Séptico/terapia , Infecções Estreptocócicas/complicações , Infecções Estreptocócicas/tratamento farmacológico
19.
Dermatol Online J ; 25(7)2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31450285

RESUMO

Numerous studies have suggested a correlation between oral health, the oral microbiome, and various dermatologic conditions, particularly psoriasis. In this study, we utilize a specially designed questionnaire administered to 265 patients at The Ohio State University's dermatology clinics to explore the relationship between psoriasis and a combination of factors that included dietary habits, oral health, and oral hygiene practices. Age, family history of psoriasis, previous diagnosis of strep throat or rheumatoid arthritis, and oral pain or discomfort experienced within the last 12 months were all found to be significant predictors of psoriasis. Additionally, higher body mass index scores, poor gum health, and speech difficulties related to dental problems were all correlated with more severe psoriasis symptoms. Conversely, patients who reported consuming fresh fruit at least once a day experienced milder symptoms. Our goal is to develop a better understanding of how and why psoriasis incidence is correlated with some of the oral health factors under review.


Assuntos
Dieta/efeitos adversos , Higiene , Saúde Bucal , Psoríase/etiologia , Adulto , Fatores Etários , Artrite Reumatoide/complicações , Estudos de Casos e Controles , Progressão da Doença , Humanos , Modelos Lineares , Modelos Logísticos , Pessoa de Meia-Idade , Gravidade do Paciente , Faringite/complicações , Faringite/microbiologia , Psoríase/genética , Estudos Retrospectivos , Fatores de Risco , Infecções Estreptocócicas/complicações , Inquéritos e Questionários
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