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1.
BMJ Case Rep ; 13(12)2020 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-33318249

RESUMO

Here, we report a novel case of corneal ulcer in a 72-year-old patient with diabetes caused by Corynebacterium amycolatum This organism should not be ignored as a harmless commensal whenever it is isolated in pure form in repeat cultures of the specimen along with a leucocyte reaction in direct microscopic examination. Moreover, this organism is multidrug-resistant, so species identification of diphtheroids is important to start appropriate antibiotic therapy. There are very few published reports of ocular infection and none of corneal ulcer by this organism.


Assuntos
Úlcera da Córnea/microbiologia , Infecções por Corynebacterium/microbiologia , Corynebacterium/isolamento & purificação , Idoso , Antibacterianos/administração & dosagem , Úlcera da Córnea/diagnóstico , Úlcera da Córnea/tratamento farmacológico , Infecções por Corynebacterium/diagnóstico , Infecções por Corynebacterium/tratamento farmacológico , Humanos , Masculino , Soluções Oftálmicas
2.
J Small Anim Pract ; 61(9): 554-560, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32734615

RESUMO

OBJECTIVES: To describe infection in companion animals with the zoonotic pathogen Corynebacterium ulcerans and to determine its prevalence in clinically-affected and healthy animals. MATERIALS AND METHODS: The clinical presentation and treatment of three cases of C. ulcerans infection is described. Two studies to determine C. ulcerans prevalence rates were undertaken: (a) a prospective study of nasal samples from healthy animals, 479 dogs and 72 cats; (b) a retrospective analysis of records of nasal samples collected over a 10-year period from 189 dogs and 64 cats affected by respiratory signs. RESULTS: Toxigenic C. ulcerans was isolated from four cats with nasal discharge while concurrent C. ulcerans and mecC methicillin-resistant S. aureus infection was detected in a dog suffering from chronic nasal discharge. Clinical features were not distinctive and all cases recovered following antimicrobial treatment. Multilocus sequence typing supported a common source for isolates from the shelter cats. Carriage rates of C. ulcerans in healthy animals were 0.42% (2/479) in dogs and 0.00% (0/72) in cats whereas in animals with signs of upper respiratory tract infection prevalence rates were 0.53% (1/189) in dogs and 6.25% (4/64) in cats. CLINICAL SIGNIFICANCE: Clinicians should be aware that dogs and cats can be infected with (or carriers of) toxigenic C. ulcerans Considering the potential zoonotic risk, assistance from medical and public health colleagues should be sought in confirmed cases.


Assuntos
Doenças do Gato , Infecções por Corynebacterium , Doenças do Cão , Staphylococcus aureus Resistente à Meticilina , Infecções Respiratórias , Animais , Doenças do Gato/tratamento farmacológico , Doenças do Gato/epidemiologia , Gatos , Corynebacterium , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/epidemiologia , Infecções por Corynebacterium/veterinária , Doenças do Cão/tratamento farmacológico , Doenças do Cão/epidemiologia , Cães , Estudos Prospectivos , Infecções Respiratórias/tratamento farmacológico , Infecções Respiratórias/epidemiologia , Infecções Respiratórias/veterinária , Estudos Retrospectivos
3.
BMC Infect Dis ; 20(1): 389, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32487026

RESUMO

BACKGROUND: Intracranial infections with Corynebacterium striatum (C. striatum) have been described sporadically in the literature over the last two decades. However, C. striatum meningitis combined with multiple abscesses has not been published before. CASE PRESENTATION: In this report, we describe the clinical and imaging findings in a 54-year-old woman with meningitis caused by C. striatum and combined with suspected brain and lung abscesses. This patient who underwent multiple fractures and a recent cut presented with headache and paraphasia. C. striatum was isolated in cerebrospinal fluid and supposedly transmitted from the skin purulent wound through blood. The patient was treated with intravenous vancomycin and had a transient improvement, but died finally. Multiple abscesses, especially in the brain, could be a reason to explain her conditions were deteriorating rapidly. CONCLUSIONS: Note that C. striatum can cause life-threatening infections. Early identification and diagnosis, early administration of antibiotics to which the bacterium is susceptible, and treatment of complications will be beneficial in patients with C. striatum-related infection.


Assuntos
Abscesso Encefálico/microbiologia , Infecções por Corynebacterium/complicações , Abscesso Pulmonar/microbiologia , Meningites Bacterianas/microbiologia , Antibacterianos/uso terapêutico , Abscesso Encefálico/diagnóstico por imagem , Abscesso Encefálico/tratamento farmacológico , Líquido Cefalorraquidiano/microbiologia , Corynebacterium/isolamento & purificação , Corynebacterium/patogenicidade , Infecções por Corynebacterium/tratamento farmacológico , Feminino , Humanos , Traumatismos da Perna/microbiologia , Abscesso Pulmonar/diagnóstico por imagem , Abscesso Pulmonar/tratamento farmacológico , Meningites Bacterianas/complicações , Meningites Bacterianas/tratamento farmacológico , Pessoa de Meia-Idade , Vancomicina/uso terapêutico
4.
J Vet Sci ; 21(3): e40, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32476314

RESUMO

The purpose of this study was to investigate the high-level mupirocin resistance (HLMR) in Gram-positive bacteria isolated from companion animals. A total of 931 clinical specimens were collected from diseased pets. The detection of mupirocin-resistant bacteria and plasmid-mediated mupirocin resistance genes were evaluated by antimicrobial susceptibility tests, polymerase chain reactions, and sequencing analysis. Four-hundred and six (43.6%) bacteria were isolated and 17 (4.2%), including 14 staphylococci and 3 Corynebacterium were high-level mupirocin-resistant (MICs, ≥ 1,024 ug/mL) harboring mupA. Six staphylococci of HLMR strains had plasmid-mediated mupA-IS257 flanking regions. The results show that HLMR bacteria could spread in veterinary medicine in the near future.


Assuntos
Antibacterianos/farmacologia , Corynebacterium/efeitos dos fármacos , Farmacorresistência Bacteriana , Mupirocina/farmacologia , Staphylococcus/efeitos dos fármacos , Animais , Doenças do Gato/tratamento farmacológico , Gatos , Infecções por Corynebacterium/tratamento farmacológico , Doenças do Cão/tratamento farmacológico , Cães , Testes de Sensibilidade Microbiana/veterinária , Reação em Cadeia da Polimerase/veterinária , Análise de Sequência de DNA/veterinária , Infecções Estafilocócicas/tratamento farmacológico
6.
BMJ Case Rep ; 12(11)2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31678926

RESUMO

A 65-year-old male patient presented with fever, fast atrial fibrillation and frank haematuria on return to Ireland from travel in East Africa. He had a systolic murmur leading to a clinical suspicion of endocarditis. He had no specific clinical features of diphtheria. Blood cultures were taken and empiric therapy commenced with benzylpenicillin, vancomycin and gentamicin. Corynebacterium diphtheriae was detected on blood culture. The isolate was submitted to a reference laboratory for evaluation of toxigenicity. While initially there was concern regarding the possibility of myocarditis, a clinical decision was made not to administer diphtheria antitoxin in the absence of clinical features of respiratory diphtheria, in the presence of invasive infection and with presumptive previous immunisation. There is no specific guidance on the role of antitoxin in this setting. The issue is not generally addressed in previous reports of C. diphtheriae blood stream infection.


Assuntos
Infecções por Corynebacterium/sangue , Corynebacterium diphtheriae/isolamento & purificação , Administração Intravenosa , Idoso , Antibacterianos/administração & dosagem , Ceftriaxona/administração & dosagem , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/microbiologia , Antitoxina Diftérica/uso terapêutico , Úlcera do Pé/complicações , Humanos , Masculino , Insuficiência da Valva Mitral/complicações , Insuficiência da Valva Mitral/microbiologia , Insuficiência da Valva Mitral/cirurgia
9.
Trop Anim Health Prod ; 51(8): 2547-2557, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31222712

RESUMO

The aim of this study was to compare the efficacy of two dry-off protocols: (a) dry cow therapy using ciprofloxacin hydrochloride 400 mg followed by the administration of an internal teat sealant composed of 4 g of bismuth subnitrate, and (b) a positive control using dry cow therapy with 250 mg cephalonium followed by the administration of 2.6 g bismuth subnitrate internal teat sealant. A total of 578 Holstein cows selected from 7 commercial herds were randomly allocated into two groups at drying off: (a) ciprofloxacin hydrochloride 400 mg (CH) associated with ITS, n = 1112 mammary quarters/296 cows, or (b) positive control (PC) = cephalonium (250 mg) associated with ITS, n = 1058 mammary quarters/282 cows). A total of 1787 out of 2170 mammary quarters (82%) had negative culture at drying off. The microorganisms most frequently isolated at drying off were CNS (5.62%), Strep. uberis (1.9%), Corynebacterium spp. (1.8%), and Staphylococcus aureus (1.01%). A total of 465 mammary quarters experienced new intramammary infections (NIMIs), and the main microorganisms causing NIMI were CNS (21.94%), Strep. uberis (17.2%), and Pseudomonas spp. (9.7%). The CH protocol was not inferior to PC, as the cure risk of mammary quarters CH-treated was at the noninferiority limit. However, the mammary quarters treated by CH protocol had 24% and 31% lower risk of overall NIMI and NIMI caused by major pathogens, respectively, than mammary quarters dried with the PC protocol. In addition, the mammary quarters treated with CH protocol had a lower risk of CM through the first 60 DIM than those treated with PC protocol. Both DCT protocols showed similar odds of microbiological cure, but the CH protocol had greater prevention against NIMI during dry-off period.


Assuntos
Antibacterianos/uso terapêutico , Cefalosporinas/uso terapêutico , Ciprofloxacino/uso terapêutico , Glândulas Mamárias Animais/microbiologia , Mastite Bovina/tratamento farmacológico , Animais , Bismuto/uso terapêutico , Brasil/epidemiologia , Bovinos , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/epidemiologia , Infecções por Corynebacterium/microbiologia , Infecções por Corynebacterium/veterinária , Feminino , Incidência , Lactação , Glândulas Mamárias Animais/efeitos dos fármacos , Mastite Bovina/microbiologia , Prevalência , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/microbiologia , Infecções Estafilocócicas/veterinária , Staphylococcus/isolamento & purificação , Infecções Estreptocócicas/tratamento farmacológico , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/microbiologia , Infecções Estreptocócicas/veterinária , Streptococcus/isolamento & purificação
10.
J Infect Chemother ; 25(11): 906-908, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31101531

RESUMO

Corynebacterium striatum, generally considered an opportunistic organism in humans, has recently been known to develop high-level daptomycin resistance (HLDR) shortly after drug exposure. To date, however, only several such clinical isolates have been described in the literature and clinical background of the resistant pathogen remains to be elucidated. Here, we report a case involving a C. striatum strain with HLDR harboring novel nucleotide mutations, together with a review of the relevant literature. To the best of our knowledge, this is the first well-investigated clinical report from Japan including a genetic investigation. Considering the rapid emergence of HLDR C. striatum in vitro experiment, there could be a number of underreporting cases. Scrupulous attention is required when administering daptomycin for the treatment of C. striatum infections, even if the organism has initially exhibited susceptibility.


Assuntos
Bacteriemia/diagnóstico , Bacteriemia/microbiologia , Infecções por Corynebacterium/microbiologia , Corynebacterium/genética , Farmacorresistência Bacteriana/genética , Idoso , Antibacterianos/uso terapêutico , Bacteriemia/tratamento farmacológico , Corynebacterium/efeitos dos fármacos , Infecções por Corynebacterium/tratamento farmacológico , Daptomicina/uso terapêutico , Humanos , Japão , Masculino
12.
World J Surg ; 43(7): 1737-1745, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31049604

RESUMO

BACKGROUND: Granulomatous mastitis (GM) is an inflammatory breast disease of unknown aetiology. It poses diagnostic and therapeutic challenges with myriad forms of clinical presentation, varying results to treatments and propensity to recur. This study aims to look at clinical and treatment factors that predispose to recurrence of GM. METHODS: We performed a retrospective review of 113 patients in our unit with histologically proven GM from 2006 to 2016. Demographic, clinical, treatment and outcomes data were collected and analysed. RESULTS: Eighty-nine patients were treated with antibiotics (78.8%), 79 (69.9%) with steroids and 23 (20.4%) patients underwent surgery. Twenty (17.7%) patients had recurrence. Patients who presented with inflammatory signs and symptoms had increased odds of having subsequent recurrence: skin changes (1.50), pain (2.00), fistula (4.39) and antibiotic treatment (6.65). Four patients (20%) with recurrence had positive bacterial cultures. All 4 grew Corynebacterium. Patients with Corynebacterium infection had a 2.64 times higher risk of recurrence. Surgery did not preclude recurrence. There was a 70% (7/10) penicillin resistance rate in our patients with positive cultures for Corynebacterium. CONCLUSION: Initial presentation with inflammatory signs and symptoms may confer increased risk of recurrence, warranting closer monitoring. Corynebacterium infection may play a part as a causative factor and risk factor for recurrence. Non-penicillin antibiotics should be considered as first-line antibiotics for patients presenting with inflammatory changes. Further prospective studies with larger patient populations might reveal information on the aetiology of GM and result in the development of a more standardized and effective treatment regimen.


Assuntos
Antibacterianos/uso terapêutico , Infecções por Corynebacterium/tratamento farmacológico , Mastite Granulomatosa/tratamento farmacológico , Mastite Granulomatosa/cirurgia , Esteroides/uso terapêutico , Adulto , Infecções por Corynebacterium/complicações , Feminino , Mastite Granulomatosa/microbiologia , Humanos , Pessoa de Meia-Idade , Resistência às Penicilinas , Recidiva , Estudos Retrospectivos , Singapura , Resultado do Tratamento
13.
Eur J Clin Microbiol Infect Dis ; 38(7): 1339-1342, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31030337

RESUMO

Corynebacterium coyleae is part of the commensal microflora of the skin, urethra, mucous membranes, and genital tract. Isolates from patients with urinary tract infection (UTI) were reported, but the pathogenic potential of this species has not been defined yet. The aim of the study is to determine whether C. coyleae could be the etiological agent of UTI and to analyze its antibiotic susceptibility. Urine samples were cultured quantitatively according to accepted laboratory procedures. The identification of bacterial isolates was carried out using the Vitek MS (bioMérieux) and antibiotic susceptibility was tested using disc diffusion according to EUCAST guidelines. Between 1 January 2017 and 30 October 2018, a total of 39 C. coyleae strains were isolated. This represented 0.32% of all urine samples cultured in the laboratory during the collection period. The strains were isolated from samples obtained from 35 women and 3 men (age median for all-64 years). One female patient presented with C. coyleae in her urine twice at an interval of 21 months. In six cases of UTI, C. coyleae was isolated in monoculture. The isolates had the same resistance pattern. A total of 11 strains were obtained from cases with a clinical diagnosis of UTI. In 13 cases, the strain was cultured in a monoculture and in 28 cases with accompanying species. All strains were susceptible to vancomycin. However, resistance to ciprofloxacin was observed for 58.4% of the strains. Urine isolates of C. coyleae must be considered as contamination or normal flora in most cases (28/39, 72%). In the remaining cases, it can be considered as potential etiologic agents, mostly in women and especially in the 6 UTI cases where C. coyleae was found as the single culture-positive species. Several of these isolates demonstrate resistance to antibiotics commonly used in empiric treatment of urinary tract infections.


Assuntos
Infecções por Corynebacterium/urina , Corynebacterium/patogenicidade , Infecções Urinárias/microbiologia , Sistema Urinário/microbiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Ciprofloxacino/uso terapêutico , Corynebacterium/efeitos dos fármacos , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/tratamento farmacológico , Farmacorresistência Bacteriana Múltipla , Feminino , Humanos , Masculino , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Estudos Retrospectivos , Infecções Urinárias/tratamento farmacológico , Adulto Jovem
14.
Eur J Clin Microbiol Infect Dis ; 38(7): 1269-1278, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30903537

RESUMO

Corynebacterium striatum is a ubiquitous colonizer of human skin and mucous membranes. It is increasingly involved in infections, especially with prosthetic devices or in immunocompromised individuals. Microbiological diagnosis is challenging and bacterial resistance is a major concern. We performed a retrospective study of monomicrobial bone and joint infections (BJI) due to C. striatum in two referral centers from April 2012 to July 2017. We collected the patients' clinical and microbiological characteristics and outcomes. We also performed a literature review of BJI due to C. striatum. We identified 12 cases (nine prosthetic joint infections, one osteosynthetic device infection, one non-union, and one arthritis) in 11 patients, five of which were immunocompromised. Microbiological diagnosis was performed with prolonged culture media. Ten out of 12 strains were susceptible to aminopenicillin, a drug class not recommended for testing by the EUCAST/CASFM guidelines, and 8/12 patients were treated with amoxicillin-rifampicin. The cure rate was 8/12, after a median follow-up period of 487.5 days (IQR 140.3-1348.5). Twelve cases of BJI due to C. striatum were previously reported. Among them, 5/12 patients were immunocompromised, 3/12 cases were acute BJI, and 2/12 were device-related infections. The diagnosis was performed by PCR in one case, and 10/12 patients were treated with glycolipopeptides, with a cure rate of 11/12. We report the largest cohort of monomicrobial BJI with C. striatum. Determination of aminopenicillin susceptibility is essential since it is frequently active in our experience, even in BJI. The cure rate of this infection seems high.


Assuntos
Amoxicilina/uso terapêutico , Antibacterianos/uso terapêutico , Artrite Infecciosa/tratamento farmacológico , Doenças Ósseas Infecciosas/tratamento farmacológico , Infecções por Corynebacterium/tratamento farmacológico , Infecções Relacionadas à Prótese/tratamento farmacológico , Rifampina/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Artrite Infecciosa/microbiologia , Doenças Ósseas Infecciosas/microbiologia , Corynebacterium/efeitos dos fármacos , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/diagnóstico , Farmacorresistência Bacteriana Múltipla , Feminino , Humanos , Hospedeiro Imunocomprometido , Articulações/microbiologia , Masculino , Pessoa de Meia-Idade , Infecções Relacionadas à Prótese/microbiologia , Estudos Retrospectivos
15.
Emerg Microbes Infect ; 8(1): 211-217, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30866774

RESUMO

Toxigenic Corynebacterium ulcerans may cause both respiratory and cutaneous diphtheria in humans. As a zoonotic emerging pathogen it has been isolated from a wide variety of animals living in captivity, such as livestock, pet, zoo and research animals and additionally in a large number of different wild animals. Here we report the isolation of tox-positive C. ulcerans in four hedgehogs with cutaneous diphtheria and pneumonia, respectively.


Assuntos
Infecções por Corynebacterium/diagnóstico , Corynebacterium/classificação , Ouriços-Cacheiros/microbiologia , Animais , Animais Selvagens/microbiologia , Corynebacterium/genética , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/tratamento farmacológico , Difteria/microbiologia , Difteria/veterinária , Toxina Diftérica/genética , Alemanha , Masculino , Filogenia , Pneumonia/microbiologia , Pneumonia/veterinária
17.
Infection ; 47(1): 121-124, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30168068

RESUMO

Corynebacterium glucuronolyticum is a rare and neglected, but increasingly recognized bacterial agent of infectious urethritis and other genitourinary syndromes in men. This is the first description of its proclivity to resurface as a cause of sustained urethritis in male patients previously treated for Chlamydia trachomatis, which represents a phenomenon that has to be differentiated from a simple post-treatment overgrowth of a colonizing agent.


Assuntos
Antibacterianos/uso terapêutico , Infecções por Chlamydia/tratamento farmacológico , Infecções por Corynebacterium/diagnóstico , Corynebacterium/isolamento & purificação , Uretrite/diagnóstico , Adulto , Chlamydia trachomatis/fisiologia , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/microbiologia , Croácia , Humanos , Masculino , Resultado do Tratamento , Uretrite/tratamento farmacológico , Uretrite/microbiologia , Adulto Jovem
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