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1.
Praxis (Bern 1994) ; 109(1): 42-46, 2020 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-31910759

RESUMO

CME Rheumatology 20: Parvovirus B19-Induced Tenosynovitis? Abstract. In this case presentation we discuss diagnostic algorithms and differential diagnoses in undifferentiated tenosynovitis. We present a case of a patient with chronic tenosynovitis in the 4th extensor tendon compartment. With unremarkable anamnesis and due to normal laboratory results a «seronegative (RF), ACPA (CCP)-negative tenosynovitis without arthritis¼ had been reported. Diagnostic and therapeutic tenosynovectomy was performed. Histologic processing revealed a positive PCR for parvovirus B19. We discuss articular and extraarticular manifestations. A parvovirus B19-associated manifestation in the musculoskeletal system is usually self-limiting. The therapy should be carried out symptomatically. In our patient there was a marked local finding, so that the complete tenosynovectomy followed by a single steroid injection led to a persistent restitutio ad integrum.


Assuntos
Artrite , Infecções por Parvoviridae , Parvovirus B19 Humano , Tenossinovite , Diagnóstico Diferencial , Humanos , Infecções por Parvoviridae/complicações , Reação em Cadeia da Polimerase , Tenossinovite/virologia
2.
Medicine (Baltimore) ; 98(35): e16993, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464949

RESUMO

RATIONALE: Parvovirus B19 (PV) infection is usually symptomless and can cause benign, short-lived conditions. Anemia associated with PRCA is the most representative hematologic manifestation, but neutropenia and thrombocytopenia have been rarely reported. PATIENT CONCERNS: Three patients were admitted to the hospital with neutropenia and thrombocytopenia. The accompanying symptoms were fever, myalgia, rash, or arthralgia, and all patients were previously healthy. DIAGNOSIS: Patients were positive for PV PCR and diagnosed with PV infection. Before the diagnosis of PV infection, 2 patients underwent BM study and almost absence of erythroid progenitor cells in BM aspiration were a clue for the PV infection. Other BM findings were hypocellular marrow and a few hemophagocytic histiocytes. INTERVENTIONS: Patients received supportive care with follow-up of CBC. OUTCOMES: All 3 patients spontaneously recovered from neutropenia and thrombocytopenia within 3 weeks without severe complications. LESSONS: The evaluation of PV infection should be considered in situations where there is neutropenia and thrombocytopenia in healthy individuals even without anemia as a differential diagnosis.


Assuntos
Neutropenia/complicações , Infecções por Parvoviridae/complicações , Infecções por Parvoviridae/diagnóstico , Trombocitopenia/complicações , Adulto , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/virologia , Parvovirus B19 Humano , Reação em Cadeia da Polimerase
3.
Transplant Proc ; 51(8): 2693-2696, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31351772

RESUMO

Parvovirus B19 (PVB19) has tropism to red blood cell progenitors and can be reactivated after organ transplantation. The aim of study was to describe clinical manifestations, laboratory findings, treatments used, and effectiveness in kidney recipients at Viet Duc hospital. A retrospective descriptive study was performed on 663 kidney recipients who were on regular follow-up from 2000 to 2018. PVB19 was detected by polymerase chain reaction PVB19-DNA. Effectiveness of therapy was assessed by Hemoglobin level. Nine out of 663 kidney recipients (1.4%) were diagnosed with PVB19-associated anemia. Eight of these 9 (89%) were diagnosed within the first 3 months following transplantation. All patients had normoscopic anemia; the average reticulocyte proportion and count were 0.15 ± 0.04% and 0.0039 ± 0.0011T/L, respectively. Graft dysfunction was observed in 4/9 (45%) patients. Treatment included reduction of immunosuppression, intravenous immunoglobulin (IVIG), and blood transfusion. All patients responded well to treatment except 1 (11%), who experienced relapse after using low dose of IVIG. PVB19-associated anemia usually occurred early after transplantation and was associated with very low reticulocyte proportion and count. Actual treatment was effective, but the risk of relapse was present.


Assuntos
Anemia/virologia , Transplante de Rim , Infecções por Parvoviridae , Adulto , Feminino , Humanos , Hospedeiro Imunocomprometido/imunologia , Transplante de Rim/efeitos adversos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/complicações , Infecções por Parvoviridae/epidemiologia , Infecções por Parvoviridae/imunologia , Parvovirus B19 Humano , Estudos Retrospectivos
4.
Emerg Infect Dis ; 25(8): 1600-16002, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31310208

RESUMO

Cutavirus was previously found in cutaneous melanoma. We detected cutavirus DNA in only 2/185 melanoma biopsies and in 0/52 melanoma metastases from patients in Germany. Viral DNA was localized in the upper epidermal layers. Swab specimens from healthy skin were cutavirus positive for 3.8% (9/237) of immunocompetent and 17.1% (35/205) of HIV-positive men.


Assuntos
Melanoma/epidemiologia , Melanoma/etiologia , Infecções por Parvoviridae/complicações , Parvovirus , Biópsia , DNA Viral , Alemanha/epidemiologia , Humanos , Melanoma/diagnóstico , Estadiamento de Neoplasias , Infecções por Parvoviridae/virologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Carga Viral
5.
PLoS One ; 14(5): e0216799, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31086415

RESUMO

Evidence has indicated that viral infection increases the risk of developing asthma. Although the association of human parvovirus B19 (B19V) or human bocavirus (HBoV) with respiratory diseases has been reported, little is known about the influence of the B19V-VP1u and HBoV-VP1u proteins on the symptoms of asthma. Herein, we investigated the systemic influence of subcutaneously injected B19V-VP1u and HBoV-VP1u recombinant proteins in an OVA-sensitized asthmatic mouse model. A significantly higher Penh ratio and IgE level were detected in the serum, bronchoalveolar lavage fluid (BALF) and the supernatant of a lymphocyte culture from mice treated with HBoV-VP1u or B19V-VP1u than in a lymphocyte culture from OVA-sensitized mice. Significantly higher levels of serum and BALF IgE, total IgG, IgG1, OVA-specific IgE and OVA-specific IgG1 were detected in mice treated with HBoV-VP1u or B19V-VP1u than in OVA-sensitized mice. Conversely, a significantly lower IgG2a level was detected in mice from the HBoV-VP1u or B19V-VP1u groups than in mice from the OVA group. The mice treated with HBoV-VP1u or B19V-VP1u exhibited more significant lung inflammatory indices, including elevated serum and BALF IL-4, IL-5, IL-10 and IL-13 levels; BALF lymphocyte, neutrophil and eosinophil counts, MMP-9 and MMP-2 activity; and the amount of lymphocyte infiltration, relative to those in the control mice or in those sensitized with OVA. These findings demonstrate that the subcutaneous injection of HBoV-VP1u or B19V-VP1u proteins in OVA-sensitized mice result in elevated asthmatic indices and suggest that human parvoviruses may increase the risk of developing airway inflammation in a mouse model of asthma.


Assuntos
Asma/virologia , Proteínas do Capsídeo/imunologia , Bocavirus Humano/imunologia , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano/imunologia , Animais , Asma/etiologia , Asma/imunologia , Proteínas do Capsídeo/química , Modelos Animais de Doenças , Feminino , Humanos , Camundongos , Camundongos Endogâmicos BALB C , Infecções por Parvoviridae/imunologia
6.
J Med Case Rep ; 13(1): 104, 2019 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-31014402

RESUMO

BACKGROUND: There are reports of the familial occurrence of Kawasaki disease but only a few reports described Kawasaki disease in siblings. However, the familial cases were not simultaneous. In these patients the idea of infective agents as trigger must be considered. CASE PRESENTATION: We describe two siblings with atypical presentations of Kawasaki disease; the sister was first diagnosed as having parvovirus infection with anemia and the brother was diagnosed as having myocarditis. The first patient was a 9-month-old Caucasian girl with fever, conjunctivitis, rash, and pharyngitis, and later she had cervical adenopathy, diarrhea and vomiting, leukocytosis, and anemia, which were explained by positive immunoglobulin M against parvovirus. However, coronary artery lesions with aneurysms were documented at day 26 after fever onset. An infusion of intravenous immunoglobulin and high doses of steroids were not efficacious to resolve the coronary lesions. She was treated with anakinra, despite a laboratory test not showing inflammation, with prompt and progressive improvement of coronary lesions. Her 7-year-old Caucasian brother presented vomiting and fever at the same time as she was unwell, which spontaneously resolved after 4 days. Four days later, he again presented with fever with abdominal pain, associated with tachypnea, stasis at the pulmonary bases, tachycardia, gallop rhythm, hypotension, secondary anuria, and hepatomegaly. An echocardiogram revealed a severe hypokinesia, with a severe reduction of the ejection fraction (20%). He had an increase of immunoglobulin M anti-parvovirus, tested for the index case of his sister, confirming the suspicion of viral myocarditis. He received dopamine, dobutamine, furosemide plus steroids, with a progressive increase of the ejection fraction to 50%. However, evaluating his sister's history, the brother showed a myocardial dysfunction secondary to Kawasaki shock syndrome. CONCLUSIONS: We report on familial Kawasaki disease in two siblings which had the same infectious trigger (a documented parvovirus infection). The brother was diagnosed as having post-viral myocarditis. However, in view of the two different and simultaneous evolutions, the girl showed Kawasaki disease with late coronary artery lesions and aneurysms, whereas the brother showed Kawasaki shock syndrome with myocardial dysfunction. We stress the effectiveness of anakinra in non-responder Kawasaki disease and the efficacy on coronary aneurysms.


Assuntos
Aneurisma Coronário/virologia , Fatores Imunológicos/uso terapêutico , Infecções por Parvoviridae/complicações , Parvovirus/isolamento & purificação , Choque/virologia , Irmãos , Cardiotônicos/uso terapêutico , Criança , Aneurisma Coronário/tratamento farmacológico , Aneurisma Coronário/fisiopatologia , Dobutamina/uso terapêutico , Dopamina/uso terapêutico , Ecocardiografia , Feminino , Humanos , Imunossupressores/uso terapêutico , Lactente , Proteína Antagonista do Receptor de Interleucina 1/uso terapêutico , Masculino , Infecções por Parvoviridae/tratamento farmacológico , Infecções por Parvoviridae/fisiopatologia , Choque/fisiopatologia , Volume Sistólico , Resultado do Tratamento
8.
J Vet Intern Med ; 33(1): 251-257, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30520162

RESUMO

BACKGROUND: Three flaviviruses (equine pegivirus [EPgV]; Theiler's disease-associated virus [TDAV]; non-primate hepacivirus [NPHV]) and equine parvovirus (EqPV-H) are present in equine blood products; the TDAV, NPHV, and EqPV-H have been suggested as potential causes of serum hepatitis. OBJECTIVE: To determine the prevalence of these viruses in horses with equine serum hepatitis. ANIMALS: Eighteen horses diagnosed with serum hepatitis, enrolled from US referral hospitals. METHODS: In the prospective case study, liver, serum, or both samples were tested for EPgV, TDAV, NPHV, and EqPV-H by PCR. RESULTS: Both liver tissue and serum were tested for 6 cases, serum only for 8 cases, and liver only for 4 cases. Twelve horses received tetanus antitoxin (TAT) 4-12.7 weeks (median = 8 weeks), 3 horses received commercial equine plasma 6-8.6 weeks, and 3 horses received allogenic stem cells 6.4-7.6 weeks before the onset of hepatic failure. All samples were TDAV negative. Two of 14 serum samples were NPHV-positive. Six of 14 serum samples were EPgV-positive. All liver samples were NPHV-negative and EPgV-negative. EqPV-H was detected in the serum (N = 8), liver (N = 4), or both samples (N = 6) of all 18 cases. The TAT of the same lot number was available for virologic testing in 10 of 12 TAT-associated cases, and all 10 samples were EqPV-H positive. CONCLUSIONS AND CLINICAL IMPORTANCE: We demonstrated EqPV-H in 18 consecutive cases of serum hepatitis. EPgV, TDAV, and NPHV were not consistently present. This information should encourage blood product manufacturers to test for EqPV-H and eliminate EqPV-H-infected horses from their donor herds.


Assuntos
Infecções por Flavivirus/veterinária , Hepatite C/veterinária , Hepatite Viral Animal/virologia , Doenças dos Cavalos/virologia , Infecções por Parvoviridae/veterinária , Animais , Feminino , Flavivirus , Infecções por Flavivirus/complicações , Infecções por Flavivirus/virologia , Hepacivirus , Hepatite C/complicações , Hepatite C/virologia , Hepatite Viral Animal/sangue , Hepatite Viral Animal/patologia , Doenças dos Cavalos/sangue , Doenças dos Cavalos/patologia , Cavalos , Fígado/patologia , Fígado/virologia , Masculino , Infecções por Parvoviridae/complicações , Infecções por Parvoviridae/virologia , Parvovirus , Estudos Prospectivos , Reação em Cadeia da Polimerase em Tempo Real/veterinária , Theilovirus
9.
Vet J ; 242: 8-14, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30503549

RESUMO

Dogs with naturally occurring canine parvovirus (CPV) infection are at risk of developing acute kidney injury (AKI) due to several factors, including severe dehydration, hypotension and sepsis. Serum creatinine (sCr) and serum urea are insensitive markers for the assessment of early kidney injury. Therefore, the aim of this study was to investigate potential kidney injury in dogs with CPV infection using both routine renal functional parameters and several kidney injury biomarkers. Twenty-two dogs with CPV infection were prospectively enrolled and compared with eight clinically healthy control dogs. Urinary immunoglobulin G (uIgG) and C-reactive protein (uCRP) were measured to document glomerular injury, whereas urinary retinol-binding protein (uRBP) and neutrophil gelatinase-associated lipocalin (uNGAL) served as markers for tubular injury. These biomarkers were compared to routine renal functional parameters, including sCr, serum urea, urinary protein:creatinine ratio (UPC) and urine specific gravity (USG). Dogs with CPV infection had significantly higher concentrations of uIgG, uCRP, uRBP and uNGAL compared to healthy dogs. In contrast, sCr was significantly lower in dogs with CPV infection compared to controls, while serum urea was not significantly different. UPC and USG were both significantly higher in CPV-infected dogs. This study demonstrated that dogs with CPV infection had evidence of AKI, which remained undetected by the routine functional markers sCr and serum urea, but was revealed by UPC, uIgG, uCRP, uRBP and uNGAL. These results emphasize the added value of novel urinary kidney injury biomarkers to detect canine patients at risk of developing AKI.


Assuntos
Lesão Renal Aguda/veterinária , Biomarcadores/urina , Doenças do Cão/diagnóstico , Infecções por Parvoviridae/veterinária , Parvovirus Canino , Lesão Renal Aguda/diagnóstico , Lesão Renal Aguda/urina , Lesão Renal Aguda/virologia , Animais , Proteína C-Reativa/urina , Estudos de Casos e Controles , Doenças do Cão/urina , Doenças do Cão/virologia , Cães , Feminino , Imunoglobulina G/urina , Lipocalina-2/urina , Masculino , Infecções por Parvoviridae/complicações , Estudos Prospectivos , Proteínas de Ligação ao Retinol/urina
10.
Zhonghua Er Ke Za Zhi ; 56(12): 945-949, 2018 Dec 02.
Artigo em Chinês | MEDLINE | ID: mdl-30518010

RESUMO

Objective: To investigate the relationship between human bocavirus 2 (HBoV2) infection and acute diarrhea in children younger than 5 years of age in a case-control study. Methods: This was a prospective case-control study. During May 2016 to December 2016, fecal specimens were collected from children ≤5 years of age with acute diarrhea who visited the Affiliated Children's Hospital of Capital Institute of Pediatrics (case group), or from children ≤5 years of age without diarrhea from Longtan Community Medical Service Center, Beijing (control group). The case group (n=240) and the control group (n=240) were divided into 8 age subgroups: ≤1 month old, >1-3 months old, >3-6 months old, >6-12 months old,>1-2 years old,>2-3 years old,>3-4 years old and >4-5 years old, and there were 30 cases in each age subgroup. The specimens were tested for 7 types of diarrhea-associated viruses, especially for HBoV2 by real-time PCR method. The HBoV2 viral load was predicted according to the cycle threshold (Ct). Finally, t-test was used to compare the differences between groups. Results: In the case group (n=240), the positive rate of norovirus was 16.7% (40 cases); rotavirus, 10.8% (26 cases); HBoV2, 7.5% (18 cases); adenovirus, 7.1% (17 cases); astrovirus, 6.3% (15 cases); parachovirus, 3.8% (9 cases); and Aich virus, 0.4% (1 case). The positive rates of HBoV2 in case group (7.5%, 18 cases) and control group (5.0%, 12 cases) showed no significant difference (χ(2)=1.280, P=0.258), as well as in different age groups (all P>0.05) . However, the mean viral load of the HBoV2 in the case group (1×10(9)copies/L with cycle threshold (Ct) 25.8) was higher than that of control group (1×10(5)copies/L with Ct 33.8), showing a significant difference (t=0.597, P=0.000). Conclusions: Norovirus and rotavirus are still the important viral pathogens in children with acute diarrhea. A higher load of HBoV2 may indicate a higher risk of acute diarrhea in children ≤5 years of age in Beijing.


Assuntos
Diarreia , Bocavirus Humano , Infecções por Parvoviridae , Pequim , Estudos de Casos e Controles , Pré-Escolar , Diarreia/virologia , Fezes , Bocavirus Humano/patogenicidade , Humanos , Lactente , Infecções por Parvoviridae/complicações , Estudos Prospectivos
11.
J S Afr Vet Assoc ; 89(0): e1-e6, 2018 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-30551702

RESUMO

Salmonellosis is a disease of major zoonotic importance and canine parvovirus is a potentially fatal cause of canine enteritis with a world-wide distribution. Persistent isolation of Salmonella during routine environmental sampling surveys of a hospital ward, reserved for the treatment of dogs with canine parvovirus infection, prompted investigation into a possible source. We hypothesised that dogs affected by canine parvovirus would have a higher prevalence of faecal salmonellae compared to an apparently healthy cohort. Seventy-four client-owned dogs naturally infected with canine parvovirus and 42 apparently healthy client-owned dogs were included in the study. This prospective, longitudinal, observational study was conducted over an 18-month period. Fresh faecal samples were collected from dogs aged 6 weeks to 9 months diagnosed with canine parvovirus infection and admitted for treatment, and from apparently healthy dogs presented for vaccination or routine hospital procedures. Faeces were submitted for the isolation, antimicrobial susceptibility testing and serotyping of salmonellae. The prevalence of faecal Salmonella shedding was 22% and 31% for the affected and apparently healthy dogs, respectively, which was not statistically different. No significant associations between Salmonella status and possible risk factors or continuous variables such as age, body weight and duration of hospitalisation were identified. All the Salmonella isolates (n = 32) were resistant to penicillin G, lincomycin and tylosin. Salmonellae from nine different serotypes were identified. The prevalence of Salmonella shedding in both groups was higher than that commonly reported, yet similar to those in previous reports on young dogs, shelter dogs or dogs fed a raw meat diet.


Assuntos
Doenças do Cão/virologia , Enterite/veterinária , Infecções por Parvoviridae/veterinária , Salmonelose Animal/microbiologia , Salmonella/isolamento & purificação , Envelhecimento , Animais , Estudos de Casos e Controles , Estudos de Coortes , Coinfecção , Doenças do Cão/microbiologia , Cães , Enterite/complicações , Fezes/microbiologia , Estudos Longitudinais , Infecções por Parvoviridae/complicações , Prevalência , Estudos Prospectivos , Salmonelose Animal/complicações
12.
Asian Pac J Cancer Prev ; 19(11): 3295-3299, 2018 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-30486640

RESUMO

Background: Colorectal cancer (CRC) as a worldwide human health concern is identified being a multifactorial subject that infection with specific viral particles such as oncogenic viruses is research interest. Human bocavirus (HBoV) as a recent isolated virus has been investigated in many respiratory and enteric diseases but rare studies evaluates it in tissue specimens especially in cancerous sections. The aim of this study was to detect the presence of HBoV genome and its genotyping in CRC patient's tissue and compare the result with matched healthy control group tissue. Method: in this retrospective case-control study, CRC cases were sporadic and non-familial cancerous while control subjects had healthy or non-malignant lesions in colon tissue. A conventional-PCR performed by specific primers for HBoV VP1 gene. After sequencing of positive PCR products, raw data used for trimming and alignment by bioinformatics software CLC Main Workbench 5 and MEGA5. SPSS v.22 used for statistical calculations. Result: a total of 157 subjects were participated that 66 were diagnosed as CRC cases and 91 were non-CRC colon tissue as control group that matched by the cases. The mean age (y) ± standard deviation of each case and control groups were 59.35±14.48 and 57.21±14.66, respectively. PCR results showed there were 1.3% (2/157) HBoV positive (of each groups one was positive). Sequencing analysis showed all were HBoV-1 genotype. Conclusion: our study showed there are low rate of HBoV genome in Iranian CRC and non-CRC colon tissue. Furthermore, the predominant genotype in our studied subsets were HBoV-1 according to phylogenetic analysis.


Assuntos
Colo/patologia , Neoplasias Colorretais/diagnóstico , Genoma Viral , Bocavirus Humano/genética , Infecções por Parvoviridae/complicações , Reto/patologia , Colo/virologia , Neoplasias Colorretais/virologia , DNA Viral , Feminino , Seguimentos , Genótipo , Bocavirus Humano/classificação , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/virologia , Filogenia , Prognóstico , Reto/virologia , Estudos Retrospectivos
13.
Sci Rep ; 8(1): 17452, 2018 11 28.
Artigo em Inglês | MEDLINE | ID: mdl-30487523

RESUMO

Preceding viral infections have mostly been described in autoimmune hepatitis (AIH) in single cases. We aimed to identify viral infections that potentially trigger AIH, as suggested for hepatitis E virus (HEV) infections. Therefore, antibodies against hepatitis A (HAV), B, C and E viruses; hepatotropic herpesviruses; and parvovirus B19 (PVB19) were analyzed retrospectively in 219 AIH patients at diagnosis, 356 patients with other liver diseases and 89 children from our center. Untreated adult AIH (aAIH) patients showed higher anti-HEV seroprevalences at diagnosis than patients with other liver diseases. Untreated aAIH patients had no increased incidence of previous hepatitis A, B or C. Antibodies against hepatotropic herpesviruses in untreated AIH were in the range published for the normal population. Untreated pediatric AIH (pAIH) patients had evidence of more previous HAV and PVB19 infections than local age-matched controls. The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities. Pediatric and adult AIH seem to be distinct in terms of genetic risk factors and preceding viral infections. While associations cannot prove causal relations, the results suggest that hepatotropic virus infections could be involved in AIH pathogenesis.


Assuntos
Vírus da Hepatite A Humana/imunologia , Hepatite A/complicações , Vírus da Hepatite E/imunologia , Hepatite E/complicações , Hepatite Autoimune/epidemiologia , Hepatite Autoimune/etiologia , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano/imunologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Anticorpos Antivirais/imunologia , Autoanticorpos/imunologia , Biomarcadores , Criança , Pré-Escolar , Suscetibilidade a Doenças , Feminino , Predisposição Genética para Doença , Hepatite A/epidemiologia , Hepatite E/diagnóstico , Hepatite E/epidemiologia , Hepatite Autoimune/diagnóstico , Humanos , Imunoglobulina G/imunologia , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Infecções por Parvoviridae/epidemiologia , Prevalência , Fatores de Risco , Estudos Soroepidemiológicos , Adulto Jovem
14.
Tidsskr Nor Laegeforen ; 138(17)2018 10 30.
Artigo em Norueguês | MEDLINE | ID: mdl-30378400

RESUMO

Background: Para- and post-infectious glomerulonephritis may be caused by various microbiological agents. We present a case of parvovirus B19 infection causing a post-infectious glomerulonephritis. Case presentation: A 30-year-old woman was admitted to hospital after four weeks of fever, flank pain and general oedema. Laboratory measurements showed elevated creatinine and alanine aminotransferase, whereas haemoglobin, albumin and thrombocyte levels were low. The urine analyses were positive for both haematuria and proteinuria. Ultrasound and CT scan of the thorax and abdomen showed multiple increased lymphoid nodes, bilateral pleural effusion, periportal oedema and ascites. C3 was low, and C4 normal. Additional immunological laboratory tests were negative. Viral serology was positive for parvovirus B19 immunoglobulin M and immunoglobulin G, confirming glomerulonephritis triggered by infection. The patient's symptoms resolved without any specific treatment, and a few months later creatinine had normalised. Interpretation: This case report illustrates the importance of microbiological laboratory work-up to further investigate acute kidney failure of unknown cause.


Assuntos
Glomerulonefrite , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano/isolamento & purificação , Doença Aguda , Adulto , Feminino , Glomerulonefrite/diagnóstico , Glomerulonefrite/virologia , Humanos
16.
J Assoc Physicians India ; 66(3): 90-1, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-30341881

RESUMO

Hemophagocytic Lymphohistiocytosis (HLH), is an uncommon, aggressive and life threatening syndrome of excessive immune activation. We report an unusual case of HLH, in a 34 year old male, who was admitted with Subarachnoid hemorrhage and cerebellar contusion in a Neurosurgical Intensive care unit, whose trigger is not clear.


Assuntos
Linfo-Histiocitose Hemofagocítica/diagnóstico , Adulto , Anticonvulsivantes/efeitos adversos , Contusão Encefálica/complicações , Humanos , Linfo-Histiocitose Hemofagocítica/complicações , Masculino , Infecções por Parvoviridae/complicações , Fenitoína/efeitos adversos , Hemorragia Subaracnóidea/complicações
17.
Curr Pediatr Rev ; 14(4): 239-252, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30124157

RESUMO

DEFINITION: Hydrops Fetalis (HF) or fetal hydrops is identified as an abnormal interstitial collection of fluid in at least 2 or more compartments of the fetal torso (peritoneal cavity, pleura, and pericardium). An alternative definition discusses about liquor accumulation in two fetal anatomical areas or an effusion in one site and anasarca. BACKGROUND: Parvovirus B-19 is a common childhood illness; the virus can cause fetal anemia, non-immune fetal hydrops, and spontaneous abortion and might lead to fetal demise. HF is the pathological distribution of body fluids between the interstitial and the intravascular areas of the fetus. Normally, in the fetal organism there is a continuous circular movement of the lymph from the interstitial space into the vascular system and vice versa. The detection of a solely effusion represents the initial stage of a systemic disorder that will lead to a fully developed hydrops or remain just a local disorder. OBJECTIVE: The connection between parvovirus B-19 and fetal hydrops. CONCLUSION: The view is unbeatable, severely swollen babies; immune hydrops is surfaced because of the maternal antibodies targeted against red blood cells with Rh positive antibody of the fetus, while the non-immune is due to a variety of pathological conditions in pregnancy.


Assuntos
Hidropisia Fetal/etiologia , Infecções por Parvoviridae/complicações , Parvovirus B19 Humano , Feminino , Feto , Humanos , Hidropisia Fetal/diagnóstico , Hidropisia Fetal/terapia , Recém-Nascido , Gravidez
18.
Rinsho Ketsueki ; 59(6): 682-687, 2018.
Artigo em Japonês | MEDLINE | ID: mdl-29973443

RESUMO

Human parvovirus B19 (HPV-B19) causes hemophagocytic lymphohistiocytosis (HLH). Here we describe a 35-year-old female with hereditary spherocytosis (HS) who developed HLH due to HPV-B19 infection. Upon admission, she had high fever and diarrhea. Laboratory findings included severe pancytopenia and elevated serum triglyceride and ferritin levels. Moreover, high HPV-B19 levels in the peripheral blood and increased reactive lymphocytosis in the bone marrow led to a diagnosis of HLH due to HPV-B19 infection. With supportive therapy and a blood transfusion, HLH symptoms, including fever and myelosuppression, improved in 1 week. However, symptoms of heart failure (HF) suddenly developed, and an echocardiography revealed diffuse systolic dysfunction, suggesting viral myocarditis due to HPV-B19 infection. Conservative management with diuretics gradually improved HF symptoms over a period of 2 weeks. HPV-B19 infection in adult patients with HS rarely results in severe HLH, but conservative therapy may improve the symptoms. Nonetheless, a careful follow-up is required after HLH improves because viral myocarditis can develop, as was seen in our patient.


Assuntos
Linfo-Histiocitose Hemofagocítica/virologia , Miocardite/virologia , Infecções por Parvoviridae/diagnóstico , Parvovirus B19 Humano , Esferocitose Hereditária , Adulto , Feminino , Humanos , Infecções por Parvoviridae/complicações
19.
Indian J Med Res ; 147(4): 391-399, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29998875

RESUMO

Background & objectives: Human parvovirus B19V (B19V) is known to be associated with erythema infectiosum commonly in children, aplastic crisis, especially in persons with underlying haemolytic disorders, hydrops fetalis in pregnancies and arthritis. This cross-sectional study was aimed to determine the presence of B19V infection in childhood febrile illnesses, association of B19V with arthropathies and in adult patients with end-stage renal disease (ESRD) on dialysis. The genetic diversity among the sequences was also analysed. Methods: A nested polymerase chain reaction (nPCR) assay was used for B19V DNA targeting VP1/VP2 region and used for testing 618 patients and 100 healthy controls. Phylogenetic analysis on nucleotide and amino acid sequences was carried out to compare our sequences with other Indian strains and global strains. Results: Among 618 samples tested, seven (1.13%) were found positive. The phylogenetic analysis revealed that all the seven sequences belonged to genotype 1 and showed low genetic diversity. The clustering pattern of seven sequences was similar both by nucleotide and by predicted amino acid sequences. The fixed effects likelihood analysis showed no positive or negatively selected sites. Interpretation & conclusions: Seven samples (4 from non-traumatic arthropathies, 2 from patients with ESRD and 1 from febrile illness patient) were found positive by nPCR. When our seven sequences were compared with global strains, the closest neighbour was other Indian strains followed by the Tunisian strains.


Assuntos
Infecções por Parvoviridae/diagnóstico , Parvovirus B19 Humano/isolamento & purificação , Adulto , Anticorpos Antivirais , Estudos de Casos e Controles , Criança , Estudos Transversais , DNA Viral , Febre/etiologia , Humanos , Índia , Infecções por Parvoviridae/complicações , Parvovirus , Filogenia
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