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1.
Rev Med Liege ; 74(11): 563-565, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31729843

RESUMO

The thyroid gland is usually resistant to infections due to its anatomy. However, suppurative thyroiditis could be found in immunocompromised patients or those with previous thyroid diseases. We report a case of thyroid abscess secondary to Salmonella enteritidis infection in an immunocompetent patient. We were not able to establish the source of infection. Clinical improvement was achieved under antibiotic treatment without complications. Early diagnosis is important as thyroid abcess may be a life threatening condition.


Assuntos
Infecções por Salmonella , Tireoidite Supurativa , Abscesso , Humanos , Infecções por Salmonella/diagnóstico , Salmonella enteritidis , Tireoidite Supurativa/diagnóstico
3.
BMC Infect Dis ; 19(1): 847, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31615435

RESUMO

BACKGROUND: Salmonella outbreaks in childcare facilities are relatively rare, most often occurring secondary to contaminated food products or poor infection control practices. We report an outbreak of Salmonella Saintpaul at a pre-school facility in Ayrshire, Scotland with atypical clinical and epidemiological features. METHODS: Following notification of the initial two cases, the multi-disciplinary Incident Management Team initiated enhanced active case finding and two environmental inspections of the site, including food preparation areas. Parent and staff interviews were conducted by the Public Health department covering attendance, symptomatology and risk factors for all probable and confirmed cases. Microbiological testing of stool samples and the facility water tank was conducted. Whole Genome Sequencing (WGS) was performed for positive stool samples at the national reference laboratory. Infection control measures were introduced iteratively due to the atypical progression of the outbreak. RESULTS: There were 15 confirmed cases and 3 children admitted to hospital during the outbreak. However, 35.7% of cases reported extremely mild symptoms. The attack rate was 15.2%, and age of affected children ranged from 18 to 58 months (mean 35 months). All cases were the same Multilocus Sequence Type (MLST50). Epidemiological investigation strongly suggested person-to-person spread within the facility. Existing infection control practices were found to be of a high standard, but introduction of additional evidence-based control measures was inadequate in halting transmission. Facility staff reported concerns about lack of parental disclosure of gastrointestinal symptoms, particularly where these were mild, with 50.0% of cases having attended while symptomatic against public health advice. Voluntary two-week closure of the facility was implemented to halt transmission, following which there were no new cases. WGS results were unavailable until after the decision was taken to close the facility. CONCLUSIONS: This is the first reported instance of a Salmonella Saintpaul outbreak at a childcare facility, or where person-to-person transmission is indicated. Clinicians should consider the influence of parental under-reporting on gastrointestinal outbreaks in childcare settings, particularly where perceived severity is low and financial or social pressures to attend work may reduce compliance. WGS cannot yet replace conventional microbiological techniques during short, localised outbreaks due to delays receiving results.


Assuntos
Infecções por Salmonella/diagnóstico , Salmonella/isolamento & purificação , Creches , Pré-Escolar , DNA Bacteriano/química , DNA Bacteriano/metabolismo , Surtos de Doenças , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Tipagem de Sequências Multilocus , Saúde Pública , Salmonella/genética , Infecções por Salmonella/epidemiologia , Escócia/epidemiologia , Sequenciamento Completo do Genoma
5.
Int J Mol Sci ; 20(18)2019 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-31546808

RESUMO

Salmonella, a common foodborne pathogen, causes many cases of foodborne illness and poses a threat to public health worldwide. Immunological detection systems can be combined with nanoparticles to develop sensitive and portable detection technologies for timely screening of Salmonella infections. Here, we developed an antibody-probe-based immuno-N-hydroxysuccinimide (NHS) bead (AIB) system to detect Salmonella. After adding the antibody probe, Salmonella accumulated in the samples on the surfaces of the immuno-NHS beads (INBs), forming a sandwich structure (INB-Salmonella-probes). We demonstrated the utility of our AIB diagnostic system for detecting Salmonella in water, milk, and eggs, with a sensitivity of 9 CFU mL-1 in less than 50 min. The AIB diagnostic system exhibits highly specific detection and no cross-reaction with other similar microbial strains. With no specialized equipment or technical requirements, the AIB diagnostic method can be used for visual, rapid, and point-of-care detection of Salmonella.


Assuntos
Anticorpos Antibacterianos/química , Anticorpos Monoclonais Murinos/química , Microbiologia de Alimentos , Nanopartículas de Magnetita/química , Salmonella/imunologia , Animais , Imunoensaio , Camundongos , Camundongos Endogâmicos BALB C , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/imunologia
6.
Food Microbiol ; 84: 103237, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31421774

RESUMO

Between 1991 and 2014 the per capita notification rate of salmonellosis in Australia increased from 31.9 to 69.7 cases per 100,000 people. Salmonella Typhimurium accounted for nearly half the human cases until the end of 2014. In this study, we used cluster analysis tools to compare S. Typhimurium isolates from a chicken-meat study with those reported to the National Enteric Pathogen Surveillance System (NEPSS) from the coincident human and non-human populations. There was limited phage type diversity within all populations and a lack of specificity of MLVA profiling within phage types. The chicken-meat study isolates were not significantly clustered with the human cases and at least 7 non-human sources, based on typing profiles (PT/MLVA combination), could be implicated as a source of human cases during the same period. In the absence of a strong surveillance system representative of all putative sources, MLVA and phage typing alone or in combination are insufficient to identify the source of human cases.


Assuntos
Tipagem de Bacteriófagos , Surtos de Doenças , Fagos de Salmonella/classificação , Salmonella typhimurium/classificação , Animais , Técnicas de Tipagem Bacteriana , Bovinos , Galinhas , Análise por Conglomerados , Humanos , Repetições Minissatélites , Aves Domésticas/microbiologia , Intoxicação Alimentar por Salmonella/diagnóstico , Intoxicação Alimentar por Salmonella/microbiologia , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/microbiologia , Salmonella typhimurium/virologia
8.
BMJ Case Rep ; 12(7)2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31345833

RESUMO

We describe an unusual case of a 58-year-old man with type 2 diabetes mellitus (T2DM) developing sepsis secondary to a prevertebral neck abscess. Following cross-sectional imaging, the patient underwent surgical drainage. Salmonella sandiego was isolated from urine, blood and pus cultures. Salmonella species neck infections represent a rare cause of focal salmonellosis, though have been reported in the literature. This is the first reported case of S. sandiego causing neck abscess. The case highlights an atypical presentation of salmonellosis, with the surprising finding of a neck abscess on cross-sectional imaging without evidence of co-existing significant discitis or osteomyelitis.


Assuntos
Abscesso/microbiologia , Diabetes Mellitus Tipo 2/fisiopatologia , Pescoço/microbiologia , Infecções por Salmonella/diagnóstico , Salmonella enterica/isolamento & purificação , Sepse/diagnóstico , Abscesso/terapia , Ceftriaxona/uso terapêutico , Ciprofloxacino/uso terapêutico , Drenagem , Humanos , Masculino , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Infecções por Salmonella/tratamento farmacológico , Sepse/complicações , Sepse/terapia , Resultado do Tratamento
9.
PLoS One ; 14(6): e0218325, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31216306

RESUMO

Based on the high sensitivity and stable fluorescence of CdTe quantum dots (QDs) in conjunction with a specific DNA aptamer, the authors describe an aptamer-based fluorescence assay for the determination of Salmonella Typhimurium. The fluorescence detection and quantification of S. Typhimurium is based on a magnetic separation system, a combination of aptamer-coated Fe3O4 magnetic particles (Apt-MNPs) and QD-labeled ssDNA2 (complementary strand of the aptamer). Apt-MNPs are employed for the specific capture of S. Typhimurium. CdTe QD-labeled ssDNA2 was used as a signaling probe. Simply, the as-prepared CdTe QD-labeled ssDNA2 was first incubated with the Apt-MNPs to form the aptamer-ssDNA2 duplex. After the addition of S. Typhimurium, they could specifically bind the DNA aptamer, leading to cleavage of the aptamer-ssDNA2 duplex, accompanied by the release of CdTe QD-labeled DNA. Thus, an increased fluorescence signal can be achieved after magnetic removal of the Apt-MNPs. The fluorescence of CdTe QDs (λexc/em = 327/612 nm) increases linearly in the concentration range of 10 to 1010 cfu•mL-1, and the limit of detection is determined to be 1 cfu•mL-1. The detection process can be performed within 2 h and is successfully applied to the analysis of spiked food samples with good recoveries from 90% to 105%.


Assuntos
Aptâmeros de Nucleotídeos/química , Técnicas Biossensoriais , Infecções por Salmonella/diagnóstico , Salmonella typhimurium/isolamento & purificação , Compostos de Cádmio/química , Óxido Ferroso-Férrico/química , Fluorescência , Humanos , Pontos Quânticos/química , Infecções por Salmonella/microbiologia , Salmonella typhimurium/patogenicidade , Telúrio/química
10.
Acta Biomed ; 90(2): 333-338, 2019 05 23.
Artigo em Inglês | MEDLINE | ID: mdl-31125015

RESUMO

BACKGROUND: Non-typhoid Salmonella (NTS) is an important cause of bacterial meningitis in newborn and infants in developing countries, but rarely in industrialized ones. We describe an unusual presentation of bacterial meningitis in an infant, focusing on his diagnostic and therapeutic management. CASE REPORT: An Italian two-month old male presented high fever and diarrhea with blood, associated with irritability. Inflammatory markers were high, cerebrospinal fluid analysis was compatible with bacterial meningitides but microbiological investigations were negative. Salmonella enteritidis was isolated from blood. Cerebral ultrasound and MRI showed periencephalic collection of purulent material. Specific antibiotic therapy with cefotaxime was initiated with improvement of clinical conditions and blood tests. Brain MRI follow up improved progressively. CONCLUSIONS: Most of pediatric patients with NTS infection develop self-limited gastroenteritis, but in 3-8% of the cases complications such as bacteremia and meningitis may occur, especially in weak patients. Cerebral imaging can be useful to identify neurological findings. Although there is no standardized treatment for this condition, specific antibiotic therapy for at least four weeks is recommended. Neuroimaging follow up is required due to high risk of relapse.


Assuntos
Cefotaxima/uso terapêutico , Meningites Bacterianas/tratamento farmacológico , Meningites Bacterianas/microbiologia , Salmonella enteritidis/isolamento & purificação , Seguimentos , Humanos , Lactente , Itália , Imagem por Ressonância Magnética/métodos , Masculino , Meningites Bacterianas/diagnóstico , Doenças Raras , Medição de Risco , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/tratamento farmacológico , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
11.
BMJ Case Rep ; 12(5)2019 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-31110064

RESUMO

Non-typhoidal Salmonella osteomyelitis in healthy children is a very rare condition. A previously healthy 7-year-old boy presented with foot pain following a small injury. Local inflammatory signs of the foot were observed, with a normal radiograph. Two weeks before, he had had gastroenteritis. Assuming cellulitis, flucloxacillin was began. Early during admission, surgical subcutaneous abscess drainage was performed and Salmonella enteritidis was identified. According to bacterial susceptibility, antibiotherapy was changed to ceftriaxone. A foot radiograph and an MRI scan, performed on the 9th and the 12th days, revealed findings suggestive of osteomyelitis of the metaphysis of the fifth metatarsal. Clinical worsening persisted and surgical extensive debridement was needed. A 6-week antibiotic treatment was completed, with a good outcome. Osteomyelitis with a poor evolution in children with risk factors (prior gastrointestinal illness, warm weather and previous exposure to antibiotics) can raise the possibility of a non-typhoidal Salmonella infection.


Assuntos
Ossos do Metatarso/microbiologia , Infecções por Salmonella/diagnóstico , Administração Intravenosa , Antibacterianos/administração & dosagem , Ceftriaxona/administração & dosagem , Criança , Desbridamento , Humanos , Imagem por Ressonância Magnética , Masculino , Ossos do Metatarso/diagnóstico por imagem , Ossos do Metatarso/cirurgia , Infecções por Salmonella/tratamento farmacológico , Salmonella enteritidis/isolamento & purificação
12.
BMJ Case Rep ; 12(5)2019 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-31076489

RESUMO

A 47-year-old Malay man who presented with fever, poor oral intake and loss of weight for 1 month duration. Further work-up revealed evidence of disseminated Salmonella infection that was further complicated with pericardial and pleural empyema. Cultures from pericardial and pleural fluids grew Salmonella species with negative serial blood cultures. Contrast enhanced CT thorax showed pleural effusion with large pericardial effusion. The patient was treated with antibiotics and drainage of pericardial and pleural empyema was done and he was discharged well.


Assuntos
Antibacterianos/uso terapêutico , Febre/microbiologia , Derrame Pericárdico/microbiologia , Derrame Pleural/microbiologia , Infecções por Salmonella/diagnóstico , Salmonella/patogenicidade , Drenagem , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/diagnóstico por imagem , Derrame Pericárdico/fisiopatologia , Derrame Pericárdico/terapia , Derrame Pleural/fisiopatologia , Derrame Pleural/terapia , Infecções por Salmonella/tratamento farmacológico , Infecções por Salmonella/fisiopatologia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Perda de Peso
13.
PLoS One ; 14(4): e0215581, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31022229

RESUMO

BACKGROUND: Clinical courses and treatment outcomes are largely unknown in patients with adult-onset immunodeficiency associated with anti-interferon-gamma autoantibodies due to the fact that it was recently recognized and anti-IFN-γ auto-Abs detection is not widely available. METHODS AND FINDINGS: Non-HIV-infected adult patients with detectable anti-IFN-γ auto-Abs diagnosed and followed at Siriraj Hospital, Bangkok, Thailand during January 2013 to November 2016 were prospectively studied. At each follow-up visit, patients were classified as stable or active disease according to symptoms and signs, and all proven OIs were recorded. Laboratory parameters, including erythrocyte sedimentation rate, C-reactive protein, and anti-IFN-γ auto-Abs level, were compared between active and stable disease episodes. We identified 80 patients with this clinical syndrome and followed them up during study period. Seventy-nine patients developed overall 194 proven opportunistic infections. Mycobacterium abscessus (34.5%) and Salmonella spp. (23.2%) were the two most common pathogens identified among these patients. Sixty-three patients were followed for a median of 2.7 years (range 0.6-4.8 years). Eleven (17.5%) patients achieved the drug-free remission period for at least 9 months. Four patients died. Anti-IFN-γ auto-Abs concentration was significantly lower at baseline and decreased over time in the drug-free remission group compared to another group (p = 0.001). C-reactive protein, erythrocyte sedimentation rate and white cell count were found to be useful biomarkers for determining disease activity during follow-up. CONCLUSIONS: Reinfection or relapse of OIs is common despite long-term antimicrobial treatment in patients with anti-IFN-γ auto-Abs. Treatment to modify anti-IFN-γ auto-Abs production may improve long-term outcomes in this patient population.


Assuntos
Autoanticorpos/imunologia , Síndromes de Imunodeficiência/imunologia , Infecções por Micobactéria não Tuberculosa/imunologia , Infecções Oportunistas/imunologia , Infecções por Salmonella/imunologia , Adulto , Idoso , Autoanticorpos/sangue , Biomarcadores/sangue , Sedimentação Sanguínea , Proteína C-Reativa/análise , Feminino , Seguimentos , Humanos , Síndromes de Imunodeficiência/complicações , Síndromes de Imunodeficiência/diagnóstico , Interferon gama/imunologia , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Infecções por Micobactéria não Tuberculosa/complicações , Infecções por Micobactéria não Tuberculosa/diagnóstico , Infecções Oportunistas/complicações , Infecções Oportunistas/diagnóstico , Estudos Prospectivos , Recidiva , Infecções por Salmonella/complicações , Infecções por Salmonella/diagnóstico , Tailândia , Adulto Jovem
14.
BMC Infect Dis ; 19(1): 330, 2019 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-30999894

RESUMO

BACKGROUND: Invasive Salmonella infections result in significant morbidity and mortality in developing countries. In Asia, typhoid and paratyphoid fever are reported to be the major invasive Salmonella infections, while invasive non-typhoidal Salmonella (iNTS) infections are believed to be uncommon. Data from Sarawak, in Malaysian Borneo, are limited. METHODS: A retrospective study identifying all children aged < 15 years with invasive Salmonella infections from 2011 to 2016 was conducted in Bintulu Hospital in Sarawak. Population incidences, clinical and bacterial characteristics were examined. RESULTS: Forty-four patients were identified during the 6-year study period: 43 had iNTS infection and 1 had typhoid fever. The average annual iNTS incidence was 32.4 per 100,000 children aged < 5 years. None of the children had malaria or HIV infection, and only 7% were severely malnourished. Salmonella Enteritidis and Salmonella Java were the commonest NTS serovars identified. Pneumonia was the most common manifestation of iNTS disease, present in 20 (47%) children. Other manifestations included gastroenteritis, fever without a source, septic arthritis and meningitis. Salmonella Enteritidis was identified in 76% of those with pneumonia, significantly more frequently than in children with other manifestations. Over 25% of children with iNTS developed severe disease and nearly 10% suffered long term morbidity or mortality. While 78% of Salmonella Java isolates were multi-drug resistant, nearly all other isolates were susceptible to most antimicrobials, including ampicillin. CONCLUSIONS: Bintulu Division in Sarawak observed a very high incidence of childhood iNTS infections. Enteric fever was uncommon. The epidemiology of invasive Salmonella infections in Malaysian Borneo differs considerably from that of neighbouring countries in Asia.


Assuntos
Infecções por Salmonella/diagnóstico , Adolescente , Anti-Infecciosos/farmacologia , Bornéu/epidemiologia , Criança , Pré-Escolar , Farmacorresistência Bacteriana Múltipla , Feminino , Humanos , Lactente , Malásia/epidemiologia , Masculino , Testes de Sensibilidade Microbiana , Pneumonia/diagnóstico , Pneumonia/epidemiologia , Estudos Retrospectivos , Salmonella/efeitos dos fármacos , Salmonella/isolamento & purificação , Infecções por Salmonella/epidemiologia , Salmonella enteritidis/efeitos dos fármacos , Salmonella enteritidis/isolamento & purificação , Sorogrupo , Febre Tifoide/diagnóstico , Febre Tifoide/epidemiologia
15.
Biosens Bioelectron ; 135: 120-128, 2019 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-31004922

RESUMO

This study presents a slidable paper-embedded plastic microdevice fully integrated with DNA extraction, loop-mediated isothermal amplification (LAMP), and colorimetric detection functionalities. The developed microdevice consists of three layers that allow a sliding movement to mix the sample and reagents for DNA purification, amplification, and detection in a sequential manner. An FTA card was employed in the main chamber for DNA extraction and purification from intact bacterial cells. Subsequently, LAMP reagents and fuchsin-stored chambers were pulled toward the main chambers for DNA amplifications at 65 °C. After 30 min, the detection reagents-stored chambers were then moved to main chambers for result analysis. For the detection of LAMP amplicons, a novel colorimetric fuchsin-based method was employed. The wide applicability of the integrated microdevice was demonstrated by successfully screening three major foodborne pathogens, namely Salmonella spp., Staphylococcus aureus, and Escherichia coli O157:H7 in food, enabling highly sensitive detection of 3.0 × 101 CFU/sample of Gram-negative bacteria (Salmonella spp. and Escherichia coli O157:H7) and 3.0 × 102 CFU/sample of Gram-positive bacteria (Staphylococcus aureus) within 75 min. The portable and integrated microdevice presented in this study holds significant promise for point-of-care applications to accurately and rapidly diagnose and control diseases.


Assuntos
Escherichia coli O157/isolamento & purificação , Doenças Transmitidas por Alimentos/microbiologia , Testes Imediatos , Salmonella/isolamento & purificação , Staphylococcus aureus/isolamento & purificação , Técnicas Biossensoriais/instrumentação , DNA Bacteriano/análise , DNA Bacteriano/genética , Desenho de Equipamento , Infecções por Escherichia coli/diagnóstico , Infecções por Escherichia coli/microbiologia , Escherichia coli O157/genética , Doenças Transmitidas por Alimentos/diagnóstico , Humanos , Dispositivos Lab-On-A-Chip , Limite de Detecção , Técnicas de Amplificação de Ácido Nucleico/instrumentação , Papel , Plásticos , Salmonella/genética , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/microbiologia , Infecções Estafilocócicas/diagnóstico , Infecções Estafilocócicas/microbiologia , Staphylococcus aureus/genética
16.
PLoS Negl Trop Dis ; 13(3): e0007187, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30883544

RESUMO

Nontyphoidal Salmonella is a major contributor to the global burden of foodborne disease, with invasive infections contributing substantially to illnesses and deaths. We analyzed notifiable disease surveillance data for invasive nontyphoidal Salmonella disease (iNTS) in Queensland, Australia. We used Poisson regression to estimate incidence rate ratios by gender, age group, and geographical area over 2007-2016. There were 995 iNTS cases, with 945 (92%) confirmed by blood culture. Salmonella Virchow accounted for 254 (25%) of 1,001 unique iNTS isolates. Invasive NTS disease notification rates peaked among infants, during the summer months, and in outback Queensland where the notification rate (95% CI) was 17.3 (14.5-20.1) cases per 100,000 population. Overall, there was a 6,5% annual increase (p<0.001) in iNTS disease incidence. In conclusion, high iNTS rates among males, infants, and the elderly require investigation of household level risk factors for NTS infection. Controlling Salmonella Virchow infections is a public health priority.


Assuntos
Surtos de Doenças/prevenção & controle , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/epidemiologia , Salmonella enterica/isolamento & purificação , Fatores Etários , Idoso , Surtos de Doenças/estatística & dados numéricos , Monitoramento Epidemiológico , Feminino , Humanos , Incidência , Lactente , Masculino , Razão de Chances , Queensland/epidemiologia , Fatores de Risco , Infecções por Salmonella/sangue , Infecções por Salmonella/microbiologia , Fatores Sexuais
17.
PLoS One ; 14(3): e0213726, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30865712

RESUMO

Salmonella Typhimurium, a zoonotic pathogen, is regarded as a major health and economic concern worldwide. Recently, monophasic variants of this serovar have been significantly associated with human gastroenteritis outbreaks globally, making its accurate identification essential for epidemiological and control purposes. We have identified and analyzed 150 S. Typhimurium from 884 Salmonella genus isolated from humans, domestic animals, poultry, food items and abattoirs origins. The Salmonella isolates were obtained from Iranian National Veterinary Reference Laboratories of 9 provinces during 2007-2016, and from five hospitals in Tehran in 2015. The isolates were evaluated biochemically, serologically, and by PCR amplification of invA, mdh, STM4492, fliC, fljA, fljB, hin genes, IS200 and DT104. invA and mdh genes were used to confirm the S. Typhimurium serotype, fliC and fljB genes for determination of monophasic variants and amplification of IS200 to discriminate the monophasic variants from the closely related serotypes. We identified 78.6% (118/150) as classical S. Typhimurium (fliC, fljB and IS200 positive), 12.6% (19/150) were IS200 negative from all isolates. DT104 is another marker for S.Typhimurium serovar typing. Contrary to EFSA guidelines 20.6% (19/29) of human isolates that lacked IS200 insertion sequence, were confirmed as S.Typhimurium. Compared to the North American/European isolates the low prevalence of fljB negative 6% (9/150) and the high abundance of fliC negative 23.3% (35/150) isolates also were indicative of a different regional atypical population. Studies have shown that the prevalence of monophasic (fljB-) S. Typhimurium worldwide is promoted by the Swine industry. Thus, one reason for this high number of different atypical strains could be inhibition of swine breeding system (house hold and industry) in Iran. These results demonstrate a need for a modified identifying protocol to overcome the regional differences.


Assuntos
Reação em Cadeia da Polimerase/normas , Infecções por Salmonella/diagnóstico , Salmonella typhimurium/genética , Animais , Técnicas de Laboratório Clínico , Elementos de DNA Transponíveis , Flagelina/genética , Variação Genética , Humanos , Irã (Geográfico)/epidemiologia , Reação em Cadeia da Polimerase/veterinária , Aves Domésticas/genética , Prevalência , Infecções por Salmonella/epidemiologia , Infecções por Salmonella/genética , Salmonella typhimurium/isolamento & purificação , Sorogrupo , Especificidade da Espécie , Suínos
19.
Infection ; 47(5): 857-860, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30771193

RESUMO

S. typhi infection rarely involves the genitourinary system. We report the first described case of acute epididymo-orchitis due to S. typhi in a 14-year-old boy from Bangladesh. A high index of suspicion should be maintained when evaluating patients coming from endemic countries also in case of unusual sites of infection.


Assuntos
Orquite/microbiologia , Infecções por Salmonella/diagnóstico , Salmonella typhi/isolamento & purificação , Adolescente , Bangladesh , Humanos , Masculino , Orquite/tratamento farmacológico , Infecções por Salmonella/tratamento farmacológico
20.
Rev Soc Bras Med Trop ; 52: e20180253, 2019 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-30652794

RESUMO

An eleven-year-old boy presented with fever and hip pain, with limited mobility of the right side of the hip. Computed tomography scan revealed an increased volume of the right coxo-femoral joint, requiring surgical drainage of purulent secretion, from which Salmonella enterica was isolated. After four weeks of treatment with third-generation cephalosporin, he was discharged with a favorable evolution. Invasive disease caused by Salmonella spp represents a small proportion of salmonellosis cases, although it is responsible for greater rates of hospitalization, morbidity and mortality. Children under 5 years, elders over 60 years and immunodeficient patients have greater risk for invasive salmonellosis.


Assuntos
Artrite Infecciosa/microbiologia , Infecções por Salmonella/microbiologia , Salmonella enterica/isolamento & purificação , Artrite Infecciosa/diagnóstico , Artrite Infecciosa/tratamento farmacológico , Criança , Humanos , Masculino , Infecções por Salmonella/diagnóstico , Infecções por Salmonella/tratamento farmacológico
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