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1.
BMC Res Notes ; 12(1): 408, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31307543

RESUMO

OBJECTIVE: Aconitum plants (Ranunculaceae) exhibit toxicity, and accidental ingestion of the plants has been reported in Japan. Identifying the cause of poisoning is important for emergency medical treatment, and a rapid and simple detection technique is required for the identification of poisoning cause. In the present study, we developed a rapid and simple method for detecting Aconitum plant DNA using a loop-mediated isothermal amplification (LAMP) assay. RESULTS: Specific LAMP primers for Aconitum plants were designed based on the trnL-trnF intergenic spacer region. Using the LAMP primers, the LAMP assay included an initiation reaction of 10 min followed by amplification for 20 min at the isothermal reaction temperature of 65 °C. The LAMP reaction was demonstrated to be specific and highly sensitive to Aconitum plants, given that the assay can be used for 1 pg of purified DNA. Using raw extracted DNA as template, the entire detection procedure from DNA extraction to final detection required only 30 min. Moreover, the protocol identified samples containing approximately 5 mg of Aconitum plants cooked and digested with artificial gastric juice. The currently proposed protocol exhibits good potential as a screening method of Aconitum plant poisoning for emergency medical care.


Assuntos
Aconitum/genética , Aconitum/envenenamento , DNA de Plantas/genética , Técnicas de Amplificação de Ácido Nucleico/métodos , Intoxicação por Plantas/diagnóstico , Animais , Humanos , Extratos Vegetais/genética , Extratos Vegetais/envenenamento , Coelhos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
2.
Toxicon ; 166: 46-55, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31102596

RESUMO

'Go Slow myopathy' (GSM) is a suspected toxic myopathy in dogs that primarily occurs in the North Island of New Zealand, and affected dogs usually have a history of consuming meat, offal or bones from wild pigs (including previously frozen and/or cooked meat). Previous epidemiological and pathological studies on GSM have demonstrated that changes in mitochondrial structure and function are most likely caused by an environmental toxin that dogs are exposed to through the ingestion of wild pig. The disease has clinical, histological and biochemical similarities to poisoning in people and animals from the plant Ageratina altissima (white snakeroot). Aqueous and lipid extracts were prepared from liver samples of 24 clinically normal dogs and 15 dogs with GSM for untargeted liquid chromatography-mass spectrometry. Group-wise comparisons of mass spectral data revealed 38 features that were significantly different (FDR<0.05) between normal dogs and those with GSM in aqueous extracts, and 316 significantly different features in lipid extracts. No definitive cause of the myopathy was identified, but alkaloids derived from several plant species were among the possible identities of features that were more abundant in liver samples from affected dogs compared to normal dogs. Mass spectral data also revealed that dogs with GSM have reduced hepatic phospholipid and sphingolipid concentrations relative to normal dogs. In addition, affected dogs had changes in the abundance of kynurenic acid, various dicarboxylic acids and N-acetylated branch chain amino acids, suggestive of mitochondrial dysfunction.


Assuntos
Doenças do Cão/induzido quimicamente , Metaboloma , Miopatias Mitocondriais/veterinária , Intoxicação por Plantas/veterinária , Alcaloides/isolamento & purificação , Animais , Cromatografia Líquida/veterinária , Doenças do Cão/metabolismo , Cães , Fígado/metabolismo , Espectrometria de Massas/veterinária , Miopatias Mitocondriais/patologia , Nova Zelândia , Intoxicação por Plantas/diagnóstico
3.
Toxicon ; 161: 28-32, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30826471

RESUMO

In this retrospective series of 97 cases of manchineel fruit ingestion reported to French Poison Control Centers between 2009 and 2017, we investigated cases of poisoning due to manchineel fruit (from the Hippomane mancinella tree). This fruit is known to be responsible for oropharyngeal and gastrointestinal tract lesions and possibly hypotension and bradycardia (previously attributed to the presence of physostigmine). The most commonly observed clinical signs were oropharyngeal pain, abdominal pain, diarrhea and oropharyngeal irritation. No major gastrointestinal tract lesions were observed in the five cases in which upper gastrointestinal (GI) endoscopy was performed. One case of laryngeal edema and one case of bradycardia were observed, but analysis of the harvested fruits did not confirm the presence of physostigmine. Ingestion of manchineel fruit can cause mild abdominal pain and digestive irritation, requiring medical attention. Rarely, when several fruits have been ingested, severe oropharyngeal injury or hemodynamic disorders may require otorhinolaryngological consultation or cardiac monitoring for several hours, respectively.


Assuntos
Frutas/envenenamento , Hippomane/envenenamento , Intoxicação por Plantas/etiologia , Adolescente , Adulto , Idoso , Feminino , Hippomane/química , Humanos , Masculino , Pessoa de Meia-Idade , Fisostigmina/análise , Intoxicação por Plantas/diagnóstico , Centros de Controle de Intoxicações , Estudos Retrospectivos , Adulto Jovem
4.
Toxicon ; 161: 33-39, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30826472

RESUMO

Larkspurs (Delphinium spp.) are native perennial plants that have a serious toxic potential to cattle on foothill and mountain rangelands in the western United States. Livestock death due to larkspur toxicity is attributed to norditerpenoid alkaloids. Diagnosing plant poisonings in livestock is often challenging. The objective of this study was to evaluate the use of three matrices; earwax, oral fluid, and nasal mucus, as noninvasive specimens to determine livestock exposure to larkspurs. Reversed phase high performance liquid chromatography - high resolution mass spectrometry was used to analyze for norditerpene alkaloids, in all three matrices, in cattle administered a single dose of larkspur. Earwax, oral fluid, and nasal mucus were collected over 6 days post-dosing. Methyllycaconitine (MLA) and deltaline concentrations in earwax ranged from 0.4 ±â€¯0.1 to 0.2 ±â€¯0.06 and 0.6 ±â€¯0.5 to 0.11 ±â€¯0.08 ng/mg, respectively. MLA and deltaline concentrations in oral fluid ranged from 0.08 ±â€¯0.03 to 0.01 ±â€¯0.002 ng/mg and 0.07 ±â€¯0.03 ng/mg to not detected (ND), respectively. MLA and deltaline concentrations in nasal mucus ranged from 0.2 ±â€¯0.13 to 0.03 ±â€¯0.01 ng/mg and 0.2 ±â€¯0.12 ng/mg to ND, respectively. The ability to detect differing norditerpene alkaloid chemotypes from two different Delphinium spp. was also possible in the three matrices. This study demonstrates the potential of earwax, oral fluid, and nasal mucus as noninvasive specimens for chemical analyses to aid in the diagnosis of livestock that may have been exposed to and poisoned by larkspur plants.


Assuntos
Aconitina/análogos & derivados , Doenças dos Bovinos/diagnóstico , Doenças dos Bovinos/etiologia , Delphinium/envenenamento , Diterpenos/toxicidade , Intoxicação por Plantas/veterinária , Aconitina/análise , Aconitina/química , Aconitina/toxicidade , Alcaloides/análise , Alcaloides/química , Alcaloides/toxicidade , Animais , Bovinos , Cromatografia Líquida de Alta Pressão , Diterpenos/análise , Diterpenos/química , Gado , Masculino , Intoxicação por Plantas/diagnóstico , Plantas Tóxicas , Manejo de Espécimes/veterinária , Estados Unidos
5.
Toxicon ; 157: 80-83, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30468757

RESUMO

The aim of this paper was to present the first report of Prosopis nigra poisoning of cattle in Argentina. Outbreaks occurred in five farms located in Salta and Santiago del Estero provinces. All animals were examined, euthanized and necropsied. Clinical signs included tongue protrusion, twitches and tremors of muscles of mastication, weight loss and lethargy. Severe atrophy of the masseter, buccinator and lingual muscles was observed, along with neuronal vacuolation in the nuclei of the trigeminal, facial, and hypoglossus nerves. These findings and the clinical signs are consistent with results obtained in animals, spontaneously and experimentally intoxicated with Prosopis juliflora in previous studies. Several species of this genus are native to Argentina. Farmers should be warned about the suspected toxicity by Prosopis nigra, since this species has wide geographical distribution in the country.


Assuntos
Doenças dos Bovinos/etiologia , Intoxicação por Plantas/veterinária , Prosopis/envenenamento , Animais , Argentina , Bovinos , Doenças dos Bovinos/diagnóstico , Surtos de Doenças/veterinária , Frutas/envenenamento , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/etiologia
6.
Pediatr Emerg Care ; 35(12): e223-e225, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28590987

RESUMO

OBJECTIVE: The study aims to describe the management of a case of life-threatening yew (Taxus baccata) intoxication. BACKGROUND: The needles of the yew tree contain highly cardiotoxic taxines. Intoxication with taxines, typically as part of suicide attempts, may lead to potentially lethal arrhythmias which often require prolonged cardiopulmonary resuscitation and other supportive measures. No specific therapy has been described. In some cases, extracorporeal life support has been used. CASE: After an attempted suicide with yew needles and out-of-hospital cardiac arrest, a female adolescent was resuscitated for 6 hours according to Advanced Cardiovascular Life Support guidelines. Complex ventricular tachycardias were treated by repeated direct current shocks and broad complex bradycardia managed with transvenous cardiac pacing. Antiarrhythmic drugs (amiodarone, lidocaine), magnesium sulfate, and supportive measures (intravenous lipids, sodium bicarbonate) were provided. The arrhythmias finally resolved, and the patient did not show any significant neurological or cardiac short-term sequelae after 24 hours. RESULTS: The authors describe the successful management of a case of severe taxine intoxication by prolonged conventional advanced cardiac life support lasting for more than 6 hours. CONCLUSIONS: In life-threatening yew intoxication, prolonged cardiopulmonary resuscitation is absolutely essential owing to the long duration of the cardiotoxic action of taxines and can lead to an outcome without cardiac or neurological sequelae.


Assuntos
Arritmias Cardíacas/tratamento farmacológico , Parada Cardíaca Extra-Hospitalar/induzido quimicamente , Folhas de Planta/envenenamento , Intoxicação por Plantas/diagnóstico , Taxus/envenenamento , Adolescente , Antiarrítmicos/uso terapêutico , Bradicardia/fisiopatologia , Bradicardia/terapia , Reanimação Cardiopulmonar/efeitos adversos , Reanimação Cardiopulmonar/normas , Ingestão de Alimentos , Cardioversão Elétrica/métodos , Feminino , Humanos , Parada Cardíaca Extra-Hospitalar/diagnóstico , Parada Cardíaca Extra-Hospitalar/terapia , Intoxicação por Plantas/fisiopatologia , Tentativa de Suicídio/psicologia , Taquicardia Ventricular/fisiopatologia , Taquicardia Ventricular/terapia , Resultado do Tratamento
7.
J Vet Emerg Crit Care (San Antonio) ; 29(2): 190-200, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30507024

RESUMO

OBJECTIVE: To describe the management and resolution of acute liver failure (ALF) in two dogs following ingestion of cheese tree (Glochidion ferdinandi) roots. CASE SUMMARIES: A 2-year-old male entire Bullmastiff and a 5-year-old female neutered German Shepherd dog were presented for acute-onset lethargy and vomiting after chewing on tree roots of a cheese tree. Both dogs developed clinical abnormalities consistent with ALF, including hepatic encephalopathy, marked increase in alanine aminotransferase activity and bilirubin concentration, and prolonged coagulation times. Treatment included administration of intravenous fluids, hepatoprotectants, vitamin K1 , antibiotics, lactulose, antacids, antiemetics, and multiple fresh frozen plasma transfusions. Follow-up examinations performed 30 days after initial presentation revealed the dogs to be clinically healthy with serum biochemical and coagulation profiles within reference intervals. NEW OR UNIQUE INFORMATION: This is the first report describing ALF in two dogs following ingestion of cheese tree (G. ferdinandi) roots. In this clinical setting, despite a poor prognosis, survival and recovery of adequate liver function were possible with medical management.


Assuntos
Doenças do Cão/diagnóstico , Falência Hepática Aguda/veterinária , Intoxicação por Plantas/veterinária , Raízes de Plantas/envenenamento , Árvores , Animais , Diagnóstico Diferencial , Doenças do Cão/sangue , Cães , Feminino , Falência Hepática Aguda/diagnóstico , Falência Hepática Aguda/etiologia , Masculino , Intoxicação por Plantas/diagnóstico
8.
J Vet Diagn Invest ; 31(1): 90-93, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30565513

RESUMO

Consumption of certain grasses belonging to the genus Panicum has been found to cause hepatogenous photosensitization and crystal-associated cholangiohepatopathy in small ruminants, and liver disease in horses, in many areas of the world. We describe herein the clinical findings, microscopic lesions, and steroidal saponin analysis of Panicum dichotomiflorum associated with fatal toxicosis in 3 juvenile goats in Nebraska. The disease presentation in our case was fulminant, with anorexia, marked icterus, and death for all affected animals in less than a week. Photosensitization was not observed. The microscopic lesions consisted of severe crystal-associated cholangiohepatopathy and nephropathy, with aggregates of clear or refractile and birefringent, acicular crystals present within bile ducts, macrophages, hepatocytes, and renal tubules. High-performance liquid chromatography-mass spectrometry of the grass samples demonstrated that dichotomin was the major steroidal saponin present (0.89 µg/mg); protodioscin was also present (0.059 µg/mg). The findings were consistent with ingestion of steroidal saponins, and P. dichotomiflorum was identified as the predominant forage available.


Assuntos
Doenças das Cabras/diagnóstico , Panicum/envenenamento , Intoxicação por Plantas/veterinária , Animais , Cromatografia Líquida de Alta Pressão , Doenças das Cabras/etiologia , Doenças das Cabras/patologia , Cabras , Nebraska , Panicum/classificação , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/etiologia , Intoxicação por Plantas/patologia , Saponinas/metabolismo
9.
Forensic Sci Rev ; 31(1): 23-36, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30594904

RESUMO

The aim of this paper is to highlight the symptomatology in three Conium maculatum intoxication incidents, one of which was fatal. A number of studies were reviewed in order to update and summarize the relevant literature on the incidence, sociodemographic variables, method of poisoning, pathophysiology, diagnosis, variables associated with survival and fatality, management, and treatment of C. maculatum intoxication as well as the biosynthesis and biological effects of poison hemlock alkaloids. Results show that hemlock poisoning is relatively rare, although incidence varies in different regions, despite its worldwide distribution. Hemlock poisoning is more common in European and especially Mediterranean countries. The majority of the patients are adult males over 38 years of age. The clinical course of hemlock poisoning includes neurotoxicosis, tremor, vomiting, muscle paralysis, respiratory paralysis/failure, rhabdomyolysis, and acute renal failure. The therapeutic management focuses on absorption reduction, close observation for complications, and supportive therapy (especially for respiration). Acute occurrence is severe and life-threatening, but the survival rate is high if treatment is provided promptly. Recovery is rapid, generally taking only a few days.


Assuntos
Conium/envenenamento , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/epidemiologia , Acidentes/mortalidade , Idoso , Alcaloides/análise , Alcaloides/biossíntese , Alcaloides/química , Animais , Antídotos/uso terapêutico , Antieméticos/uso terapêutico , Carvão Vegetal/uso terapêutico , Cromatografia Líquida , Conium/anatomia & histologia , Conium/fisiologia , Cromatografia Gasosa-Espectrometria de Massas , Lavagem Gástrica , Humanos , Gado , Masculino , Estrutura Molecular , Fitoterapia , Piperidinas/análise , Paralisia Respiratória/induzido quimicamente , Paralisia Respiratória/terapia , Rabdomiólise/induzido quimicamente , Rabdomiólise/terapia , Suicídio
10.
Vet Ital ; 55(4): 369-373, 2019 12 31.
Artigo em Inglês | MEDLINE | ID: mdl-31955560

RESUMO

An outbreak of neurological disorders in a flock of 20 sheep coming from a rural farm in Civitella Roveto, Italy, occurred in winter 2015. All the animals showed tonic-clonic convulsions followed by muscle paralysis associated with dilated pupils, tremor, tachycardia, tachypnea and diarrhea. The presence of bundles of dry broom of Spartium junceum L. in the feed, eaten by the animals supported the hypothesis of plant intoxication. Two animals died after worsening of clinical signs. The anatomopathological findings and the laboratory results ruled out viral or bacterial infections or accidental exposure to other toxics. Phytochemical study showed the presence of large amount of cytisine, a nicotinic acetylcholine receptor agonist, in all parts of the plant eaten by the animals. Clinical and pathological findings, the complete remission of clinical signs after the exclusion of dry broom from the diet, together with the results of phytochemical analyses results corroborated the hypothesis of S. junceum L. intoxication.


Assuntos
Alcaloides/envenenamento , Ração Animal/envenenamento , Intoxicação por Plantas/veterinária , Doenças dos Ovinos/diagnóstico , Spartium/envenenamento , Animais , Azocinas/envenenamento , Diagnóstico Diferencial , Dieta/veterinária , Feminino , Itália , Masculino , Intoxicação por Plantas/diagnóstico , Quinolizinas/envenenamento , Ovinos , Doenças dos Ovinos/induzido quimicamente
11.
J Emerg Med ; 55(3): e61-e63, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30077363

RESUMO

BACKGROUND: Cases of human poisoning associated with Nicotiana glauca Graham are quite rare. Patients may consume the plant by mistaking it for spinach or use it as a folk remedy. The toxin stimulates the acetylcholine receptors in the central and autonomic nervous systems. A prompt and appropriate supportive treatment is crucial for survival. CASE REPORT: A 72-year-old female with a known breast cancer was brought to our emergency department (ED) with complaints of nausea and vomiting. The patient stated that her complaints started 2 h after she had cooked and eaten a plant in the hopes that it would help cure her cancer. On the second hour after arrival, the patient became confused. It was observed that the chest wall movements had decreased and that the patient had difficulty breathing. Due to respiratory failure, orotracheal intubation was performed to secure the airway. A sample of the plant that was eaten was requested from the patient's relatives. According to an Internet search, the plant sample was identified as N. glauca Graham. The patient was diagnosed with N. glauca Graham poisoning. The patient was extubated after 30 h. On 3-month follow-up, the patient was neurologically intact and had no complaints related to poisoning. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Patients with incurable diseases such as cancer tend to try folk remedies and can end up in ED. In patients who present with muscle paralysis and respiratory failure, emergency physicians should consider N. glauca Graham as a cause of plant poisoning.


Assuntos
Folhas de Planta/envenenamento , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/terapia , Insuficiência Respiratória/induzido quimicamente , Insuficiência Respiratória/terapia , Tabaco/envenenamento , Idoso , Neoplasias da Mama/dietoterapia , Culinária , Feminino , Humanos
13.
Ann Cardiol Angeiol (Paris) ; 67(3): 215-218, 2018 Jun.
Artigo em Francês | MEDLINE | ID: mdl-29759800

RESUMO

OBJECTIVE: To identify a hypertensive clinical form of atropine or anticholinergic toxidrome secondary to accidental consumption of Datura seeds. PATIENTS AND METHODS: We report two cases of Datura intoxication in two children who presented marked anticholinergic syndrome whose diagnosis was made by the anamnesis and the clinic. RESULT: Patient 1: A 5-year-old boy, returns home agitated with balance disorders. He was admitted to pediatric resuscitation unit. His Glasgow score was 11/15. The child made inconsistent remarks. The neurological examination revealed mydriasis. Hemodynamically, the blood pressure was 145/91mmHg, the heart rate was 145 bpm. The rest of the examination noted a temperature of 37.5°, a bladder globe. Standard biological tests were normal. ECG found sinus tachycardia. Urine analysis revealed a positive alkaloid reaction with the presence of atropine. The evolution was favorable after 48hours. Patient 2: 45-month-old boy admitted to a state of severe agitation of toxic origin. The clinical examination showed a central and peripheral anticholinergic symptomatology with severe hallucinations, severe hypertension, and a heart rate at 190 bpm. The rest of the examination found erythema in the thorax and upper limbs, bilateral mydriasis. The toxicological report confirmed the presence of alkaloids. The evolution was favorable. CONCLUSION: Hypertension crisis and other anticholinergic clinical signs of Datura stramonium intoxication achieve favorable outcomes in children.


Assuntos
Síndrome Anticolinérgica/etiologia , Datura stramonium/envenenamento , Hipertensão/induzido quimicamente , Intoxicação por Plantas , Síndrome Anticolinérgica/diagnóstico , Pré-Escolar , Humanos , Hipertensão/diagnóstico , Masculino , Intoxicação por Plantas/diagnóstico
14.
J Vet Med Sci ; 80(3): 485-487, 2018 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-29311434

RESUMO

Lilies are considered nephrotoxic only to domestic cats, which belong to the family Felidae of the suborder Feliformia. However, a 7-month-old female meerkat, belonging to the family Herpestidae of the suborder Feliformia, presented with oliguria, seizure, tachypnea, self-biting, and nystagmus after it ingested lilies. The meerkat died approximately 40 hr after lily ingestion. Gross and histopathologic lesions consistent with acute renal failure were conspicuous in the animal. The renal lesions were acute tubular necrosis, corresponding to the typical pathological changes of lily toxicosis in cats. In addition, massive hepatocyte necrosis and pulmonary congestion/edema were observed. These findings suggest that lily toxicosis in meerkats is characterized by pulmonary and hepatic failure, in addition to the renal failure observed in domestic cats.


Assuntos
Herpestidae/metabolismo , Lilium/envenenamento , Intoxicação por Plantas/veterinária , Animais , Feminino , Nistagmo Patológico/etiologia , Nistagmo Patológico/veterinária , Oligúria/etiologia , Oligúria/veterinária , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/etiologia , Convulsões/etiologia , Convulsões/veterinária , Taquipneia/etiologia , Taquipneia/veterinária
16.
Med J Malaysia ; 73(6): 453-454, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30647232

RESUMO

Datura plants contain anticholinergic properties. Consumers may present with a spectrum of anticholinergic symptoms, including hallucination, agitation, tachycardia, delirium, hyperthermia, and dilated pupils. Prompt identification of the symptoms with appropriate treatment can be life-saving. Some patients might not be able to provide history and therefore recognition of toxidromes is imperative. Awareness should be built among the public who may be exposed to such fruits or plants.


Assuntos
Datura/envenenamento , Frutas/envenenamento , Intoxicação por Plantas/diagnóstico , Adulto , Inibidores da Colinesterase/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fisostigmina/uso terapêutico , Intoxicação por Plantas/tratamento farmacológico , Intoxicação por Plantas/etiologia
17.
J Vet Diagn Invest ; 30(2): 286-289, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29202673

RESUMO

Solanum glaucophyllum, a toxic plant known for its calcinogenic effects, causes enzootic calcinosis in ruminant and monogastric animals. We describe an outbreak of enzootic calcinosis that occurred in a herd of 110 horses grazing pastureland heavily contaminated with S. glaucophyllum in Buenos Aires province, Argentina. Ten horses developed clinical signs, and 6 horses died. Clinical signs included abnormal gait (stiff-legged action, short strides), stiffness, thoracolumbar kyphosis, reluctance to move, wide stance, chronic weight loss, weakness, recumbency, and difficulty standing. Autopsy of 2 horses revealed severe mineralization of the aorta, pulmonary arteries, heart, and lungs, consistent with enzootic calcinosis. Although horses usually have very selective grazing behavior, under food restriction conditions, they can ingest the toxic plants and can develop the disease. Enzootic calcinosis should be considered as a differential diagnosis in horses grazing S. glaucophyllum-invaded pasturelands with compatible clinical signs and lesions.


Assuntos
Doenças dos Cavalos/diagnóstico , Plantas Tóxicas/envenenamento , Solanum glaucophyllum/envenenamento , Animais , Argentina , Calcinose/patologia , Calcinose/veterinária , Diagnóstico Diferencial , Feminino , Doenças dos Cavalos/patologia , Cavalos , Masculino , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/veterinária
19.
Toxicon ; 137: 54-57, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28716647

RESUMO

An innovative method was developed to detect fluoroacetate poisoning in cattle by headspace/gas chromatographic analysis of earwax samples of intoxicated cattle. Samples were collected from 2 groups of cattle subjected to induced fluoroacetate intoxication, each group receiving a different dose of acetamide (antidote). Monofluoroacetic acid was detected in samples of intoxicated cattle in concentrations inversely proportional to the dose of acetamide. Thus, earwax analysis represents a successful approach for detection and monitoring of fluoroacetate poisoning.


Assuntos
Doenças dos Bovinos/diagnóstico , Cerume/química , Fluoracetatos/envenenamento , Intoxicação por Plantas/veterinária , Rubiaceae/envenenamento , Acetamidas/administração & dosagem , Animais , Antídotos/administração & dosagem , Bovinos , Doenças dos Bovinos/tratamento farmacológico , Cromatografia Gasosa , Masculino , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/tratamento farmacológico , Rubiaceae/química
20.
Clin Toxicol (Phila) ; 55(7): 670-673, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28463019

RESUMO

CONTEXT: Accidental ingestion of foxglove (Digitalis purpurea) can cause significant cardiac toxicity. We report a patient who ingested foxglove mistaking it for comfrey and developed refractory ventricular arrhythmias. The patient died despite treatment with digoxin-specific antibody fragments (DSFab) and veno-arterial extracorporeal membrane oxygenation (VA-ECMO). CASE DETAILS: A 55-year-old woman presented to the emergency department with nausea, vomiting and generalized weakness eight hours after drinking "comfrey" tea. She had bradycardia (54 beats/min) and hyperkalemia (7.6 mEq/L). Electrocardiogram revealed a first-degree atrioventricular conduction block with premature atrial contractions, followed by polymorphic ventricular tachycardia three hours after arrival. A serum digoxin level was 151.2 ng/mL. The patient developed ventricular fibrillation while waiting for Digibind infusion. Resuscitation was performed and an emergent VA-ECMO was set up. A total of eight vials of Digibind were given over the next 16 hours. She temporarily regained consciousness, but remained hemodynamically unstable and subsequently developed lower limb ischemia and multiple organ failure, and she expired on hospital day seven. A botanist confirmed that the plant was foxglove. CONCLUSIONS: The diagnosis of cardiac glycoside plant poisoning can be difficult in the absence of an accurate exposure history. In facilities where DSFab is unavailable or insufficient, early VA-ECMO might be considered in severely cardiotoxic patients unresponsive to conventional therapy.


Assuntos
Acidentes , Glicosídeos Cardíacos/envenenamento , Confrei , Digitalis/envenenamento , Cardiopatias/induzido quimicamente , Intoxicação por Plantas/etiologia , Cardiotoxicidade , Eletrocardiografia , Oxigenação por Membrana Extracorpórea , Evolução Fatal , Feminino , Cardiopatias/diagnóstico , Cardiopatias/terapia , Humanos , Fragmentos Fab das Imunoglobulinas/uso terapêutico , Pessoa de Meia-Idade , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/terapia , Valor Preditivo dos Testes , Ressuscitação , Fatores de Tempo , Resultado do Tratamento
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