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1.
N Z Med J ; 133(1520): 120-124, 2020 08 21.
Artigo em Inglês | MEDLINE | ID: mdl-32994602

RESUMO

Spontaneous bleeding in the head and neck region is exceedingly rare, particularly in the absence of trauma or an underlying disorder. We describe a case of an atraumatic lingual haematoma in an 88-year-old male presenting with threatened airway obstruction. The only risk factor our patient had was Aspirin use. Our patient was able to be managed conservatively with observation in the hospital's high dependency unit (HDU) and intravenous steroid (Dexamethasone) and antibiotic (Amoxicillin + Clavulanic acid) therapy. We discuss this case to highlight the importance of recognising an impending airway emergency in the setting of deep space bleeding or swelling.


Assuntos
Obstrução das Vias Respiratórias/etiologia , Hematoma/complicações , Língua/patologia , Administração Intravenosa , Idoso de 80 Anos ou mais , Combinação Amoxicilina e Clavulanato de Potássio/uso terapêutico , Antibacterianos/uso terapêutico , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Quimioterapia Combinada/métodos , Hematoma/tratamento farmacológico , Humanos , Masculino , Língua/irrigação sanguínea , Resultado do Tratamento
2.
Medicine (Baltimore) ; 99(27): e21140, 2020 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-32629750

RESUMO

INTRODUCTION: Treating blood stasis is effective in treating obesity and metabolic diseases in traditional Korean medicine. The aim of this prospective observational study is to determine the effectiveness of the diagnosis index for metabolic diseases with blood stasis by analyzing clinical data and blood samples. METHODS AND ANALYSIS: We will perform a prospective observational study. Participants who meet the inclusion criteria will be recruited from the Dongguk university Ilsan Oriental hospital. The outcomes are resistin, serum amyloid P component, C-reactive protein, D-dimer, and blood stasis scores. In addition, the blood pressure, ankle-brachial pressure index, brachial-ankle pulse wave velocity, body mass index, waist circumference, and levels of blood lipid will be assessed. DISCUSSION: Through this study, we could collect specific data for diagnosing metabolic diseases with blood stasis. Therefore, the findings of this study will provide a summary of the current state of evidence regarding the effectiveness of the diagnosis index in managing metabolic disease with blood stasis. ETHICS AND DISSEMINATION: The study was approved by the Institutional Review Board of the Dongguk University Ilsan Oriental Hospital (DUIOH-2018-09-001-007). The results will be published in a peer-reviewed journal and will be disseminated electronically and in print. TRIAL REGISTRATION NUMBER: Clinical Research Information Service: KCT0003548.


Assuntos
Medicina Tradicional Coreana/métodos , Doenças Metabólicas/diagnóstico , Doenças Metabólicas/terapia , Língua/irrigação sanguínea , Adulto , Idoso , Índice Tornozelo-Braço/métodos , Pressão Sanguínea/fisiologia , Índice de Massa Corporal , Feminino , Humanos , Lipídeos/sangue , Masculino , Doenças Metabólicas/complicações , Doenças Metabólicas/metabolismo , Pessoa de Meia-Idade , Estudos Prospectivos , Análise de Onda de Pulso/métodos , República da Coreia/epidemiologia , Língua/patologia , Circunferência da Cintura/fisiologia
4.
Ann Palliat Med ; 9(4): 2400-2407, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32692238

RESUMO

As one of the most urgent public health events, coronavirus disease 2019 (COVID-19) has attracted worldwide attention. This case highlighted the importance of close coordination between Chinese medicine and western medicine in the diagnosis and treatment, as well as the need for rapid dissemination of clinical information related to patient care with this emerging infection. We reported a COVID-19 case confirmed in China and described the identification, diagnosis, clinical course, and management of the case. The patient had initial mild symptoms at presentation; it progressed to severe pneumonia on the 10th day of onset. This cured case supplied a time series analysis of tongue characteristics found in severe COVID-19. Chinese medicine formulae were tweaked by tongue characteristics, which include tongue color, fur thickness, and fur color. Tongue images were obtained every two days, and the changes were firmly related to the progression of COVID-19. These tongue characteristics could be used as effective, non-intrusive indices for the distinct stages of COVID-19 stages. Our study was the first time tongue diagnosis was applied in time series analysis of the progression of COVID-19 disease. We found that tongue color, fur thickness, and fur color were closely related to the progression of COVID-19 by analyzing various tongue images obtained regularly. Based on this success, we will further apply tongue diagnosis to tongue characteristics of COVID-19 patients to help limit the risk of COVID-19.


Assuntos
Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/terapia , Medicina Tradicional Chinesa , Pneumonia Viral/diagnóstico , Pneumonia Viral/terapia , Língua/patologia , Adulto , Humanos , Masculino , Pandemias , Índice de Gravidade de Doença
5.
J Cancer Res Ther ; 16(3): 445-451, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719249

RESUMO

Introduction: Several studies regarding tumor-stroma ratio (TSR) in colorectal, esophageal, breast, endometrial, and cervical carcinomas have been done in the past with significant results. Objectives: The objectives of this study were to (1) study and grade TSR in buccal mucosa and tongue squamous cell carcinoma (SCC), (2) grade inflammatory cell infiltrate surrounding the tumor, and (3) correlate the above two parameters with tumor grade, lymph node metastasis, lymphovascular invasion (LVI), and perineural invasion (PNI). Materials and Methods: Totally, 25 patients of buccal SCC and 16 cases of tongue SCC were included in the study. TSR was assessed visually on the hematoxylin and eosin-stained tissue sections by two independent observers. Cases were categorized into two groups: One with high TSR >50% (stroma poor) and the other with low TSR <50% as the stroma-rich group. TSR was correlated with tumor size, lymph node metastasis, inflammatory cell infiltrate, LVI, and PNI. Data were analyzed by the Statistical Package for the Social Sciences version 16.0 (Chicago, IL, USA) for Windows. The Chi-square and Fischer's exact tests were applied in the analysis of categorical variable. Results and Conclusion: SCC of buccal mucosa showed a significant correlation between TSR and size of the tumor (P = 0.001). We found that smaller the tumor size ≤2 cm (Stage T1), lesser the TSR, and size >2 cm was found to be associated with higher TSR. Hence, higher TSR (stroma poor) was associated with an adverse pathological characteristic, i.e., advanced T significantly. There was no significant correlation between TSR and inflammatory infiltrate with grade of the tumor, lymph node metastasis, LVI, and PNI. In 16 cases of SCC of the tongue; no correlation was observed between TSR and inflammatory infiltrate with tumor size, grade of the tumor, lymph node metastasis, LVI, and PNI. TSR has been studied in various malignancies (mostly adenocarcinomas) including laryngeal SCCs; however, it has never been studied on oral SCCs.


Assuntos
Carcinoma de Células Escamosas/patologia , Mucosa Bucal/patologia , Neoplasias Bucais/patologia , Células Estromais/patologia , Neoplasias da Língua/patologia , Língua/patologia , Adulto , Idoso , Carcinoma de Células Escamosas/imunologia , Feminino , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/imunologia , Neoplasias Bucais/imunologia , Gradação de Tumores , Estadiamento de Neoplasias , Estudos Retrospectivos , Fatores de Risco , Células Estromais/imunologia , Língua/imunologia , Neoplasias da Língua/imunologia , Adulto Jovem
7.
J Ayub Med Coll Abbottabad ; 32(2): 266-267, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32584007

RESUMO

Venolymphatic malformations (VLM) are the rare congenital disorders but the parotid gland VLMs are the rarest. Most of the parotid lesions present with unilateral swellings. Aetiology is unknown. Interestingly, this case came in OPD with the macroglossia and only complaint was cosmetic problem. Diagnosis was confirmed on the basis of Magnetic resonance imaging which is gold standard. Doppler ultrasonography showed low flow. Intra lesion electro cautery was done. There is need to focus on malformations and work to find out the causes.


Assuntos
Macroglossia/congênito , Glândula Parótida , Criança , Eletrocoagulação , Humanos , Macroglossia/diagnóstico , Macroglossia/patologia , Macroglossia/cirurgia , Imagem por Ressonância Magnética , Masculino , Glândula Parótida/anormalidades , Glândula Parótida/irrigação sanguínea , Glândula Parótida/cirurgia , Língua/diagnóstico por imagem , Língua/patologia , Língua/cirurgia , Ultrassonografia
8.
Ann R Coll Surg Engl ; 102(7): 514-518, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32436723

RESUMO

INTRODUCTION: Major glossectomy is the treatment of choice in locally advanced tongue cancer. It remains the only option in the presence of recurrent or residual disease. The long-term outcomes for patients undergoing major glossectomy have traditionally been poor, with significant morbidity and poor oncological outcomes. The aim of this study was to report on oncological outcomes in patients undergoing major glossectomy. METHODS: All patients undergoing major glossectomy between 2014 and 2018 were included in the study. The data of 85 patients with advanced carcinoma of the oral tongue were evaluated. All were under the care of a single surgical and reconstructive team at two hospitals in Mumbai. RESULTS: The median patient age was 45 years. At the most recent follow-up, 55 patients (65%) were alive, 47 of whom were disease free. Twenty-nine patients (34%) had locoregional recurrence and twenty-five (29%) had distant metastasis. At a median follow-up of 19 months, rates for 2-year locoregional control, disease free survival (DFS) and overall survival (OS) were 69%, 61% and 62% respectively. Perinodal extension demonstrated a trend towards poor DFS (p=0.060), as did perineural invasion (p=0.055). Node positivity was a significant factor for poor OS, DFS and locoregional control. Multiple node involvement was significantly associated with poor OS on multivariate analysis (p=0.002). CONCLUSIONS: Node positivity and multiple node involvement were associated with poor outcomes. Major glossectomy may be offered as a curative option for selected patients with advanced carcinoma of the oral tongue with node negative or limited neck nodal disease (N1).


Assuntos
Glossectomia/métodos , Recidiva Local de Neoplasia/epidemiologia , Estadiamento de Neoplasias , Neoplasias da Língua/cirurgia , Língua/patologia , Adolescente , Adulto , Idoso , Intervalo Livre de Doença , Feminino , Seguimentos , Humanos , Índia/epidemiologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Estudos Retrospectivos , Taxa de Sobrevida/tendências , Língua/cirurgia , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/secundário , Adulto Jovem
9.
Am J Chin Med ; 48(4): 923-944, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32436424

RESUMO

Chronic insomnia is a disease which brings intense mental pain and disturbing complications to patients worldwide. The oral microbiome exhibits a mechanistic influence on human health. Therefore, it is crucial to understand the oral microbial diversity in insomnia. Tongue diagnosis has been considered a critical basic procedure in insomnia therapeutic decision-making in Traditional Chinese Medicine (TCM). Hence, it is significant to elucidate the various oral microbiome differences in chronic insomnia patients with different tongue features. In this paper, we used 16S rRNA gene sequencing and bioinformatics analysis to investigate dynamic changes in oral bacterial profile and correlations between chronic insomnia patients and healthy individuals, as well as in patients with different tongue coatings. Moreover, the relationship between the severity of insomnia and oral microbiota was explored. Our findings showed that chronic insomnia patients harbored a significantly higher diversity of oral bacteria when compared to healthy controls. More importantly, the results revealed that the diversity and relative abundance of the bacterial community was significantly altered among different tongue coatings in patients but not in healthy individuals. Oral bacteria with a relative abundance [Formula: see text]1% and [Formula: see text] among different tongue groups were considered remarkable bacteria, which included three phyla Proteobacteria, Bacteroidetes, Gracilibacteria, and four genera, Streptococcus, Prevotella_7, Rothia, and Neisseria. Our findings indicate that changes in oral microbiome correlate with tongue coatings in patients with chronic insomnia. Thus, the remarkable microbiome may provide inspiration for further studies on the correlation between tongue diagnosis and oral microbiome in chronic insomnia patients.


Assuntos
Bactérias/isolamento & purificação , Medicina Tradicional Chinesa , Distúrbios do Início e da Manutenção do Sono/microbiologia , Distúrbios do Início e da Manutenção do Sono/patologia , Língua/microbiologia , Língua/patologia , Adolescente , Adulto , Idoso , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , RNA Ribossômico 16S , Risco , Índice de Gravidade de Doença , Adulto Jovem
10.
Tissue Cell ; 63: 101319, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32223947

RESUMO

Salivary epidermal growth factor (EGF) plays an important role in the maintenance of the oral and gastro-esophageal mucosa. Sialoadenectomy delays healing of oral wounds and affects lingual papillae. In this work, we aimed to determine the effect of EGF deficiency induced by sialoadenectomy and evaluate the effect of exogenous EGF administration on the lingual papillae and taste buds in rats. Thirty male adult Wistar albino rats were equally divided into 3 groups; sham-operated control group, sialoadenectomy group and group of sialoadenectomy + EGF. EGF was given 8 weeks after sialoadenectomy in a dose of 1 µg /ml/day in drinking water for 2 weeks. The anterior two-thirds of the tongue was dissected and cut longitudinally into two halves; one half for light microscope and the other for electron microscope examinations. Saliva and blood were collected to determine salivary and plasma EGF. Our results revealed that sialoadenectomy significantly reduced plasma and saliva levels of EGF which resulted in severe disruption of the architecture of lingual papillae. These changes were effectively improved by the exogenous EGF administration. In conclusion, EGF supplementation reversed the effects of sialoadenectomy and restored almost normal architecture of lingual papillae and taste buds.


Assuntos
Fator de Crescimento Epidérmico/metabolismo , Glândulas Salivares/metabolismo , Papilas Gustativas/metabolismo , Língua/metabolismo , Animais , Fator de Crescimento Epidérmico/deficiência , Fator de Crescimento Epidérmico/farmacologia , Mucosa Esofágica/efeitos dos fármacos , Mucosa Esofágica/metabolismo , Humanos , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/metabolismo , Ratos , Saliva/efeitos dos fármacos , Saliva/metabolismo , Glândulas Salivares/efeitos dos fármacos , Glândulas Salivares/cirurgia , Papilas Gustativas/efeitos dos fármacos , Papilas Gustativas/cirurgia , Língua/efeitos dos fármacos , Língua/patologia , Língua/cirurgia
11.
Dermatol Online J ; 26(1)2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-32155030

RESUMO

Symmetric lipomatosis of the tongue (SLT) is rare and characterized by diffuse growth and unencapsulated lipomas. An 87-year-old man was referred for evaluation of tongue lesions. Intraoral findings showed soft yellowish nodules with a smooth shiny surface diffusely on the lateral border of the tongue, bilaterally. Our clinical diagnosis was multiple tongue lipomas and an incisional biopsy was done. Histopathological examination revealed unencapsulated lobules of mature adipocytes with slight variation in the size and shape, confirming the diagnosis of lipoma. The final diagnosis was SLT. On follow-up at 6 months, the tongue findings were unchanged and no new lesions were observed.


Assuntos
Lipomatose/patologia , Neoplasias da Língua/patologia , Idoso de 80 Anos ou mais , Biópsia , Diagnóstico Diferencial , Humanos , Lipomatose/diagnóstico , Lipomatose Simétrica Múltipla/diagnóstico , Masculino , Língua/patologia
12.
Am J Pathol ; 190(6): 1332-1342, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32194051

RESUMO

The cyclin-dependent kinase inhibitor 2A (CDKN2A)/alternate reading frame (ARF) locus consists of two overlapping tumor suppressor genes, p16INK4a and p14ARF (p19ARF in mice), encoding two unrelated proteins in alternative reading frames. Previous reports suggest that p16INK4a and p14ARF alterations independently exhibit differential roles, and p16INK4a is more closely associated with a poor prognosis in oral cancer. However, the role of p16INK4a-specific loss in oral squamous cell carcinogenesis remains unclear. The authors assessed chemical carcinogen 4-nitroquinoline 1-oxide (4NQO)-induced multistep oral squamous cell carcinogenesis in mice carrying p16INK4a-specific loss with retention of the p19ARF gene (p16INK4a-/-). 4NQO-treated p16-/- mice exhibited a higher incidence and multiplicity of oral squamous cell carcinoma (OSCC) development relative to 4NQO-treated wild-type mice. 4NQO-treated p16INK4a-/- OSCC cells exhibited higher proliferation and up-regulation of Arf, transcription factor E2f1, tumor protein p63 (tp63), and oncogenic ΔNp63, an isoform p63, compared with observations in 4NQO-treated wild-type OSCC cells. Furthermore, the overexpression of oncogenic ΔNp63 was associated with human OSCC. In conclusion, these results in mice indicate the biological significance of p16INK4a-specific loss with retention of p19ARF in oral squamous cell carcinogenesis, and ΔNp63 may be a potential target for OSCC.


Assuntos
Inibidor p16 de Quinase Dependente de Ciclina/genética , Neoplasias Bucais/genética , Carcinoma de Células Escamosas de Cabeça e Pescoço/genética , Língua/metabolismo , Animais , Inibidor p16 de Quinase Dependente de Ciclina/metabolismo , Progressão da Doença , Humanos , Camundongos , Camundongos Knockout , Neoplasias Bucais/metabolismo , Neoplasias Bucais/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Língua/patologia
13.
J Craniofac Surg ; 31(4): e334-e337, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32176002

RESUMO

OBJECTIVE: To enable tongue incisions to be repaired more easily, rapidly, and practically, particularly in pediatric patients by using 2-octyl cyanoacrylate (OCA) tissue adhesive. METHODS: A single linear incision was made on the midline dorsal part of the tongue. Twenty-four rats were randomly divided into the four groups: Group 1 (n = 6), OCA healing at day 5; group 2 (n = 6), OCA healing at day 21; group 3 (n = 6), Vicryl healing at day 5; group 4 (n = 6), Vicryl healing at day 21. In groups 1 and 2, OCA was applied to the incision site. The incisions of the rats in groups 3 and 4 were closed using Vicryl sutures. Histopathological examination was compared between and within the groups at day 5 and 21. RESULTS: The operation duration was significantly shorter with OCA than with Vicryl sutures(P < 0.001). Regarding the histopathological results, there were no differences between group 1 and group 3 in epithelial regeneration, inflammation, fibroblastic activity, edema, presence of giant cells, fibrin deposition, ulceration, abscess formation, and granulation tissue. However, moderate infiltration of acute inflammatory cells was significantly more frequent in group 1 than in group 3. At day 5, the incidence of moderate foreign body residue was significantly higher in group 1 than in group 3. No difference was observed between group 2 and group 4 at day 21 (P > 0.05). CONCLUSION: OCA is a practical, rapid, and effective method for repairing tongue lacerations. Although infiltration by inflammatory cells and foreign bodies increased in the early period, the long-term results of OCA were indistinguishable from those of suturing.


Assuntos
Cianoacrilatos/farmacologia , Lacerações/patologia , Lesões dos Tecidos Moles/patologia , Suturas , Língua/patologia , Animais , Feminino , Lacerações/tratamento farmacológico , Lacerações/cirurgia , Procedimentos Neurocirúrgicos , Ratos , Ratos Sprague-Dawley , Lesões dos Tecidos Moles/tratamento farmacológico , Lesões dos Tecidos Moles/cirurgia , Língua/cirurgia
14.
Indian J Pathol Microbiol ; 63(1): 112-115, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32031137

RESUMO

Neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease, is a type of genodermatoses having an autosomal dominant inheritance pattern and is recently considered as a RASopathy. Such patients are very much prone to develop mesenchymal tumors. However, carcinomas are quite rare in NF1 patients. This case study is the first case of oral squamous cell carcinoma (SCC) in tongue of an NF1 patient. A 35-year-old male reported to the Department of Oral Pathology in a tertiary care center with a chief complain of a painful ulcer on tongue for last 1 month. For confirmation of diagnosis of NF1, the "Diagnostic Criteria for Neurofibromatosis Type 1" was followed. Biopsied specimen of the tongue lesion was examined under microscope and histopathological features were suggestive of infiltrating SCC. Immunohistochemistry with Pan CK and beta-catenin was positive. RASopathy, WNT-beta-catenin pathway alteration, heat shock factor 1 production, and miRNA activity are investigated to explain the pathogenesis of malignancies in NF1 patients. In this first case of tongue SCC, we have found out the altered WNT-beta-catenin pathway.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Neurofibromatose 1/diagnóstico , Neurofibromatose 1/patologia , Neoplasias da Língua/diagnóstico , Adulto , Biópsia , Técnicas Histológicas , Humanos , Imuno-Histoquímica , Masculino , Transdução de Sinais , Língua/patologia , Via de Sinalização Wnt
15.
Medicina (Kaunas) ; 56(2)2020 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31991568

RESUMO

BACKGROUND AND OBJECTIVES: Bisphosphonates (BPs) are selective inhibitors of osteoclasts, used for the treatment of bone disorders. The objective of this study is to investigate the possible effects of BPs on the tongue's mucosa. MATERIALS AND METHODS: Specimens of the tongue of 20 female 12-month old Wistar rats were taken. Ten were used as control group, while in the remaining alendronate (Fosamax, Merck) was administered per os from 13 weeks. Observation of the harvested samples was made by Transmission Electron Microscopy (TEM). RESULTS: In the experimental group, focal alterations were observed to various extent in all specimens. The basement membrane was intact. Furthermore, an increase at the intercellular space was observed, predominantly at the middle layer, and the desmosomes were disorganized. In the lamina propria focal edema was observed. CONCLUSIONS: Investigation on the effect of BPs on the tongue's mucosa through TEM hasn't been documented in the past. According to our results, BPs seem to cause mild mucosal lesions on the tongue.


Assuntos
Difosfonatos/efeitos adversos , Mucosa Bucal/efeitos dos fármacos , Osteoporose/tratamento farmacológico , Animais , Conservadores da Densidade Óssea/efeitos adversos , Conservadores da Densidade Óssea/uso terapêutico , Difosfonatos/uso terapêutico , Modelos Animais de Doenças , Feminino , Microscopia Eletrônica/métodos , Mucosa Bucal/patologia , Mucosa Bucal/fisiopatologia , Osteoporose/prevenção & controle , Ratos , Ratos Wistar , Língua/efeitos dos fármacos , Língua/patologia , Língua/fisiopatologia
16.
J Oral Pathol Med ; 49(5): 404-408, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31990082

RESUMO

OBJECTIVE: The aim of this systematic review was to gather the available evidence about proliferative verrucous leukoplakia. This systematic review was conducted to answer the question: "What are the main clinical features of PVL patients?". MATERIAL AND METHODS: A systematic review of the literature was done following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements. An electronic research was carried out using different electronic databases; PubMed, and Scopus. Inclusion criteria were papers which reported at least 10 patients with proliferative verrucous leukoplakia and were published not more than 10 years ago. RESULTS: A total of 285 records were identified through databases, although only 6 of them were eligible. Most patients were women, above 60 years of age (67.4). Additionally, 28 of them were non-smokers (66.6%) and 24 were non-habitual drinkers (57.1%). The most common locations were gingiva (50.9%), buccal mucosa (44.9%), and tongue (40.6%) CONCLUSION: Level C can be established to conclude the proliferative verrucous leukoplakia demographic data, risk factors, malignant transformation, and location. A strict follow-up on these patients should be mandatory, even after surgical management since they have a high recurrence rate and a malignant transformation.


Assuntos
Carcinoma Verrucoso/diagnóstico , Leucoplasia Oral/diagnóstico , Carcinoma Verrucoso/patologia , Transformação Celular Neoplásica , Gengiva/patologia , Humanos , Leucoplasia Oral/patologia , Mucosa Bucal/patologia , Língua/patologia
17.
Acta Histochem ; 122(2): 151503, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31955907

RESUMO

The current study aimed to investigate the tongue (lingual) morphometry, histology, and histochemistry of two chiropterans endemic in the Egyptian fauna, and having different feeding preferences. The tongues of nine adult individuals of each species were utilized in our investigation. The tongue of fruit-eating bat was observed relatively longer than the one of insect-eating bat. Grossly, the insect-eating bat had a lingual prominence on the dorsum of lingual body, while the fruit-eating bat had a concave midline over the lingual body. Histologically, numerous forms of lingual papillae were scattered along the dorsal epithelium of the tongue. The lingual papillae of the fruit-eating bat seem to be well adapted for piercing the skin of a fruit and liquid sap retention. The lingual glands of both species were lodged in the muscular layer. Two main sets were identified; the serous von Ebner's gland usually seen accompanied by the circumvallate papillae and Weber's gland with mixed mucoserous secretions. Von Ebner's gland showed more prominent acidic mucins, while Weber's gland expressed neutral mucins. The lingual epithelium of the fruit-eating bat had an outer covering of cornified non-nucleated epithelium. On the other hand, the insect-eating bat had an outer covering of nucleated epithelium. It is for the first time to record the existence of the entoglossal plates of both species which consisted of a bony core in the fruit-eating bat and a cartilaginous element in the insect-eating bat. The current study represents an attempt to shed more light on the tongue evolution among mammalian vertebrates.


Assuntos
Epitélio/patologia , Pele/metabolismo , Papilas Gustativas/patologia , Língua/patologia , Animais , Quirópteros , Egito , Frutas/metabolismo , Microscopia Eletrônica de Varredura/métodos
19.
Am J Otolaryngol ; 41(3): 102393, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31932026

RESUMO

OBJECTIVE: The purpose of this study is to analyze the basic demographics of patients who underwent frenulectomy at our institution as well as additional considerations regarding age, location of procedure, and possible effects on aspiration. METHODS: A retrospective chart review was performed based on CPT codes for frenulectomy and basic demographic data was collected. Other information such as presenting symptoms, type of ankyloglossia, location of the procedure, and modified barium swallow study (MBSS) information were also obtained. RESULTS: A total of 226 (66.4% male) patients underwent frenulectomy in the study time frame. Younger patients underwent frenulectomy for feeding symptoms (average age 6.5 months) and older children typically presented with speech related symptoms (average age 3.8 years). Of patients who had MBSS before and after the procedure, 5/11 (43%) had improvement of their aspiration after frenulectomy. CONCLUSIONS: Symptomatic ankyloglossia is more common in boys. Two age groups typically present for frenulectomy, infants for feeding difficulties and toddlers/preschoolers for speech related difficulties. Children with aspiration may benefit from frenulectomy, though aspiration is unlikely to resolve if other comorbidities are present. Proper evaluation and documentation of anatomy and functional tongue movement is important for future studies and decision-making regarding frenulectomy.


Assuntos
Anquiloglossia/complicações , Anquiloglossia/cirurgia , Transtornos de Deglutição/etiologia , Freio Lingual/cirurgia , Procedimentos Cirúrgicos Bucais/métodos , Aspiração Respiratória/etiologia , Fatores Etários , Anquiloglossia/patologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Retrospectivos , Fatores Sexuais , Distúrbios da Fala/etiologia , Língua/patologia , Língua/fisiopatologia , Resultado do Tratamento
20.
Am J Otolaryngol ; 41(3): 102402, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31982210

RESUMO

PURPOSE: Suspension laryngoscopy is a commonly performed procedure in otolaryngology. During the procedure, the laryngoscope applies direct force to the tongue. Postoperative tongue symptoms include pain, swelling, numbness, taste disturbance, and rarely motor deficits. Duration and magnitude of force applied have previously been associated with post-operative throat and tongue pain, respectively. We sought to correlate postoperative tongue symptoms with magnitude of force applied and/or duration of suspension and investigate any risk factors for tongue morbidity. MATERIALS AND METHODS: A sample of patients undergoing suspension laryngoscopy between 2015 and 2018 were prospectively recruited. Those with preexisting tongue symptoms, disease or surgery were excluded. Patients completed preoperative and postoperative questionnaires evaluating tongue swelling, numbness, motion and taste disturbance. Symptoms were subjectively scored on a visual scale from 0 to 10. Patient demographics, past medical and social history were also recorded. Intraoperative pressures were measured using a spring force scale, positioned between the suspension arm and Mayo stand. Initial and end suspension forces and duration of suspension were recorded. RESULTS: 120 patients met inclusion criteria, of which 63 completed both preoperative and postoperative questionnaires. 6 patients (9.5%) experienced postoperative tongue symptoms. Suspension force and duration of suspension were not significantly predictive of postoperative tongue symptoms. While all symptomatic patients were current or former cigarette smokers, smoking status was not found to be a statistically significant factor. CONCLUSIONS: Neither suspension forces nor duration of suspension were predictive of postoperative tongue morbidity. Further research is needed to evaluate the role of smoking status on postoperative tongue symptoms.


Assuntos
Hipóxia/etiologia , Hipóxia/patologia , Laringoscopia/efeitos adversos , Resultados Negativos , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Pressão/efeitos adversos , Doenças da Língua/etiologia , Doenças da Língua/patologia , Língua/patologia , Adulto , Idoso , Fenômenos Biomecânicos , Edema , Feminino , Humanos , Hipóxia/fisiopatologia , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Movimento (Física) , Dor , Complicações Pós-Operatórias/fisiopatologia , Fatores de Risco , Inquéritos e Questionários , Paladar , Língua/fisiopatologia , Doenças da Língua/fisiopatologia , Adulto Jovem
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