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1.
Artigo em Inglês | MEDLINE | ID: mdl-31859844

RESUMO

Although the salivary glands present several functions, there are few studies evaluating these glands in Chagas disease (CD). This study aimed to compare the percentage of collagen, the presence of inflammation, the density of chimase and tryptase mast cells, the area and density of lingual salivary gland acini in autopsied individuals with and without (CD). We analyzed 400 autopsy reports performed in a tertiary public hospital from 1999 to 2015 and selected all the cases in which tongue fragments were collected (27 cases), 12 with chronic CD without megaesophagus (CH) and 15 without CD (non-chagasic - NC). The histological sections of the tongue were stained by Picrosirius red for collagen evaluation and Hematoxylin-eosin for morphometric evaluation of salivary gland acini and inflammation. Anti-chimase and anti-tryptase antibodies were used for the immunohistochemical evaluation of mast cells. The chagasic patients presented higher volume and lower density of salivary glands acini. There was no difference in the collagen percentage, inflammation and density of mast cell chymase and tryptase between the groups. Although we did not observe a significant difference between the groups regarding the collagen percentage, inflammatory process and mast cell density, our results suggest that even without megaesophagus, chagasic patients present hypertrophy of the lingual salivary glands and lower acinar density probably due to mechanisms independent of the esophagus-glandular stimulus.


Assuntos
Células Acinares/patologia , Doença de Chagas/patologia , Glândulas Salivares/patologia , Língua/patologia , Idoso , Doença Crônica , Feminino , Humanos , Hipertrofia , Imuno-Histoquímica , Masculino
2.
Ned Tijdschr Tandheelkd ; 126(11): 565-570, 2019 Nov.
Artigo em Holandês | MEDLINE | ID: mdl-31730133

RESUMO

Sometimes it is difficult to diagnose temporal arteritis because the complaints may vary, change in intensity and are not always characteristic. The condition is a cranial form of giant-cell arteritis affecting large and medium-sized arteries. The first manifestation of temporal arteritis can be a sore tongue that does not manifest any abnormalities during a clinical investigation. In a later stage patients sometimes develop ulceration or necrosis of a part of one side of the tongue. Other symptoms can be a recently developed headache, jaw claudication and acute loss of vision. To diagnose temporal arteritis, histological investigation of a biopsy of the temporal artery is carried out. The treatment consists of long-term use of corticosteroids. A patient in your practice with inexplicable pain on one side of the tongue, without clinical abnormalities, or an ulceration of the tongue without an immediately apparent cause may have temporal arteritis.


Assuntos
Arterite de Células Gigantes , Artérias Temporais/patologia , Doenças da Língua , Biópsia , Diagnóstico Diferencial , Arterite de Células Gigantes/diagnóstico , Humanos , Língua/patologia , Doenças da Língua/diagnóstico
3.
BMC Oral Health ; 19(1): 250, 2019 11 20.
Artigo em Inglês | MEDLINE | ID: mdl-31747943

RESUMO

BACKGROUND: Oral lichenoid reaction (OLR) is a type IV cell-mediated immune response in the oral cavity. There is an established relationship between various dental materials and OLR, but few cases reports reported the occurrence of a lichenoid reaction in association with the use of a Hawley retainer. CASE PRESENTATION: A female patient (twenty years of age) has been complaining of a reddish painful area on the tongue, which started one year ago and has been increasing in size over time. The patient completed orthodontic treatment two years ago and has been using a Hawley retainer for orthodontic retention since then. After performing histological analysis and patch test, the lesion was diagnosed as a lichenoid reaction to the Hawley retainer. Topical corticosteroids were prescribed, and the patient was asked to stop using the retainer and followed for six months. CONCLUSIONS: It is difficult to diagnose lichenoid lesions and even more challenging to differentiate between OLP and OLR, therefore it is essential to do a full intraoral and extraoral examination. OLL can occur in association with Hawley retainer, which we believe could be because it is made of an acrylic based material. Generally, OLL resolves after removal of the cause.


Assuntos
Erupções Liquenoides/diagnóstico , Contenções Ortodônticas/efeitos adversos , Língua/patologia , Feminino , Humanos , Líquen Plano Bucal , Erupções Liquenoides/induzido quimicamente , Adulto Jovem
4.
BMJ Case Rep ; 12(9)2019 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-31570356

RESUMO

The case involves a 62-year-old female native of the USA with a history of bipolar disorder and chronic obstructive pulmonary disease who presented with intractable diarrhoea. Prior to the index admission, she was admitted to the intensive care unit and required pericardiocentesis for an idiopathic pericardial effusion with tamponade physiology. Following discharge, she suffered intractable diarrhoea and represented for medical evaluation. She had a painful, swollen tongue as well as persistent hypoglycaemia and required glucose infusions. She had adrenal function testing which revealed adrenal insufficiency. Vitamin testing revealed normal B12 and folate levels but undetectable levels of thiamine, riboflavin and niacin. Her symptoms and signs resolved entirely with appropriate vitamin supplementation. Niacin (vitamin B3) is essential for multiple metabolic pathways, and severe deficiency may cause clinical syndrome of pellagra which is most commonly associated with diarrhoea, delirium and dermatitis. Additional physiological derangements may include adrenal insufficiency, insulin hypersensitivity and pericarditis.


Assuntos
Diarreia/etiologia , Niacina/deficiência , Pelagra/diagnóstico , Tiamina/uso terapêutico , Língua/patologia , Complexo Vitamínico B/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Pelagra/tratamento farmacológico , Pelagra/fisiopatologia , Recidiva , Resultado do Tratamento
5.
Int J Exp Pathol ; 100(4): 244-252, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31577062

RESUMO

Irinotecan is one of the most important anti-tumour drugs against a broad spectrum of malignancies, but is known to be associated with possible oral complications. The aim of the present study was to evaluate the effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood using different histological and immunohistochemical methods. Twenty juvenile male albino rats were divided equally into two groups: control and irinotecan-treated group (single injection of 200 mg irinotecan/kg, then kept for four weeks without treatment). The tongue specimens were processed for light microscopy and scanning electron microscopy. The irinotecan-treated group showed statistically significant shortening and thinning of the lingual papillae. There was loss of the normal appearance of the filiform papillae with focal cell loss alternating with areas of hyperkeratosis. Focal separation of the keratin layer, some nuclear changes and vacuolation of some epithelial cells were detected. Dilated congested blood vessels and mild mononuclear cellular infiltration were encountered. Atrophic fungiform papillae with ill-defined taste bud cells were observed. A statistically significant decrease in the pattern of Ki67 immunohistochemical staining reaction was detected in comparision to the control group. Scanning electron microscopy revealed different signs of atrophy of the tongue papillae. Focal areas of desquamation of lingual papillae were observed revealing some filiform papillae with desquamated surface, bisected tips and evident thinning. Some extravasated red blood cells could be detected. Thus irinotecan caused significant morphological and morphometrical alterations of the tongue mucosa in particularly the filiform papillae.


Assuntos
Antineoplásicos/farmacologia , Irinotecano/farmacologia , Língua/efeitos dos fármacos , Língua/patologia , Animais , Antineoplásicos/efeitos adversos , Imuno-Histoquímica , Irinotecano/efeitos adversos , Antígeno Ki-67 , Masculino , Microscopia Eletrônica de Varredura , Ratos
6.
An Bras Dermatol ; 94(4): 449-451, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644619

RESUMO

Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal mucosae, lips and floor of the mouth. The present report describes one patient with a geographic lesion on the hard palate associated with lingual lesions and another patient who had multiple geographic lesions both in the hard and soft palate without lingual lesions. We found 64 cases in the English literature of ectopic locations with 22 palate involvement. No case of simultaneous involvement of the hard and the soft palate was found.


Assuntos
Glossite Migratória Benigna/patologia , Palato/patologia , Estomatite/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Língua/patologia
10.
J Bras Pneumol ; 45(4): e20180264, 2019 Aug 15.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31432889

RESUMO

OBJECTIVE: To determine whether airway narrowing during obstructive events occurs predominantly at the retropalatal level and results from dynamic changes in the lateral pharyngeal walls and in tongue position. METHODS: We evaluated 11 patients with severe obstructive sleep apnea (OSA) and 7 healthy controls without OSA during wakefulness and during natural sleep (documented by full polysomnography). Using fast multidetector CT, we obtained images of the upper airway in the waking and sleep states. RESULTS: Upper airway narrowing during sleep was significantly greater at the retropalatal level than at the retroglossal level in the OSA group (p < 0.001) and in the control group (p < 0.05). The retropalatal airway volume was smaller in the OSA group than in the control group during wakefulness (p < 0.05) and decreased significantly from wakefulness to sleep only among the OSA group subjects. Retropalatal pharyngeal narrowing was attributed to reductions in the anteroposterior diameter (p = 0.001) and lateral diameter (p = 0.006), which correlated with an increase in lateral pharyngeal wall volume (p = 0.001) and posterior displacement of the tongue (p = 0.001), respectively. Retroglossal pharyngeal narrowing during sleep did not occur in the OSA group subjects. CONCLUSIONS: In patients with OSA, upper airway narrowing during sleep occurs predominantly at the retropalatal level, affecting the anteroposterior and lateral dimensions, being associated with lateral pharyngeal wall enlargement and posterior tongue displacement.


Assuntos
Tomografia Computadorizada Multidetectores/métodos , Doenças Faríngeas/diagnóstico por imagem , Doenças Respiratórias/diagnóstico por imagem , Apneia Obstrutiva do Sono/diagnóstico por imagem , Língua/diagnóstico por imagem , Adulto , Idoso , Estudos de Casos e Controles , Humanos , Masculino , Pessoa de Meia-Idade , Palato/diagnóstico por imagem , Palato/patologia , Palato/fisiopatologia , Doenças Faríngeas/patologia , Doenças Faríngeas/fisiopatologia , Faringe/diagnóstico por imagem , Faringe/patologia , Faringe/fisiopatologia , Polissonografia , Valores de Referência , Doenças Respiratórias/patologia , Doenças Respiratórias/fisiopatologia , Apneia Obstrutiva do Sono/patologia , Apneia Obstrutiva do Sono/fisiopatologia , Língua/patologia , Língua/fisiopatologia , Vigília/fisiologia
11.
Eur J Radiol ; 118: 19-24, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31439241

RESUMO

PURPOSE: By comparing styloglossus and hyoglossus muscle invasion (SHMI) of oral tongue squamous cell cancer (OTSCC) on MR imaging to pathological depth of invasion (DOI) and prognosis, we aimed to evaluate the clinical significance of MR imaging findings of SHMI. METHOD: Forty-five, early stages and clinically N0 OTSCCs were retrospectively reviewed. Data included pathological DOI, DOI on MR imagings, two-year potential cervical lymph node positive, locoregional control, disease-free survival, and overall survival. Data were statistically compared between the groups with MR evidence of SHMI (SHMI+) and without MR evidence of SHMI (SHMI-). RESULTS: There were 17 SHMI + and 28 SHMI-. Elective neck dissections performed on 13 cases revealed five node positive cases, all of which were SHMI + . Pathological DOI in SHMI + was significantly larger than SHMI- (average 9.0 vs 4.6 mm, p < 0.001). All SHMI + revealed pathological DOI larger than 4 mm. The two-year potential cervical lymph node positive rate of SHMI + was significantly higher than SHMI- (p =  0.01). Locoregional control rate and disease-free survival of SHMI+ were significantly lower than in SHMI- (p =  0.02). There was no significant difference in overall survival. Interobserver agreement in evaluation of SHMI on MR imaging was good (kappa value = 0.72, p <  0.001). CONCLUSIONS: Pathological DOIs of SHMI + were all larger than 4 mm, which is the cut-off point that National Comprehensive Cancer Network recommends for neck dissection, and SHMI + had a worse prognosis than SHMI-. SHMI + can be used as a criterion for elective neck dissection.


Assuntos
Carcinoma de Células Escamosas/patologia , Imagem por Ressonância Magnética/métodos , Esvaziamento Cervical , Músculos do Pescoço/diagnóstico por imagem , Neoplasias da Língua/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/diagnóstico por imagem , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculos , Músculos do Pescoço/patologia , Invasividade Neoplásica/patologia , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , Língua/diagnóstico por imagem , Língua/patologia , Neoplasias da Língua/diagnóstico por imagem
12.
Orv Hetil ; 160(33): 1319-1323, 2019 Aug.
Artigo em Húngaro | MEDLINE | ID: mdl-31401857

RESUMO

Ectomesenchymal chondromyxoid tumor is a rare benign intraoral soft tissue neoplasm. Till date, 93 cases have been reported in literature. Clinically, it presents as a slowly growing, painless, firm, submucosal swelling mainly occurring on the anterior two thirds of the dorsum of the tongue. Histopathologically, the tumor is characterized by a well circumscribed, lobular proliferation of round, polygonal, or fusiform cells in a net-like pattern in a myxoid to chondromyxoid background. Although it shows a morphological resemblance to myoepitheliomas of soft tissue and skin, the exact histogenesis remains unclear; a recent publication of a large series has demonstrated recurrent RREB1-MKL2 gene fusions in 90% of the cases, suggesting the possibility of a new entity. The diagnosis is largely supported by immunhistochemical investigations. Here, we present a new case of ECT occurring in a 62-year-old male who presented with a leading complaint of slowly growing painless mass arising from the anterior part of the tongue measuring about 3 cm. This lesion was diagnosed 4 years before recent admittance, but the patient did not undergo the scheduled surgical intervention and was lost to follow-up. As the tumor was still persisting and moderately enlarging, he came back to our clinic. Finally, the mass was completely resected; after 24 month of follow-up, he is doing well, with no signs of recurrence. Orv Hetil. 2019; 160(33): 1319-1323.


Assuntos
Proteínas de Ligação a DNA/genética , Mesenquimoma/patologia , Neoplasias da Língua/patologia , Língua/patologia , Fatores de Transcrição/genética , Proteínas de Ligação a DNA/metabolismo , Fusão Gênica , Humanos , Masculino , Mesenquimoma/cirurgia , Pessoa de Meia-Idade , Mioepitelioma , Recidiva Local de Neoplasia , Língua/cirurgia , Neoplasias da Língua/genética , Neoplasias da Língua/cirurgia , Fatores de Transcrição/metabolismo
15.
An. bras. dermatol ; 94(4): 449-451, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1038316

RESUMO

Abstract: Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal mucosae, lips and floor of the mouth. The present report describes one patient with a geographic lesion on the hard palate associated with lingual lesions and another patient who had multiple geographic lesions both in the hard and soft palate without lingual lesions. We found 64 cases in the English literature of ectopic locations with 22 palate involvement. No case of simultaneous involvement of the hard and the soft palate was found.


Assuntos
Humanos , Masculino , Feminino , Palato/patologia , Estomatite/patologia , Glossite Migratória Benigna/patologia , Língua/patologia , Pessoa de Meia-Idade , Mucosa Bucal/patologia
16.
J Neurol ; 266(10): 2518-2523, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31256280

RESUMO

BACKGROUND: Late-onset Pompe disease (LOPD) is an often misdiagnosed inherited myopathy for which treatment exists. We noticed a bright tongue sign on brain MRIs of two patients who were admitted to the ICU for respiratory failure of unclear origin, and who were eventually diagnosed with LOPD. This led us to systematically review brain MRIs of patients with LOPD and various other neuromuscular disorders (NMD). MATERIALS AND METHODS: Chart and brain MRI review of patients with LOPD and other NMD. RESULTS: Abnormalities of the tongue were observed in 11/33 of the patients studied. In 10/11 patients, no comments were made with regard to the tongue abnormalities in the radiology report. Bright tongue sign was seen in 4/6 patients with LOPD and 4/28 patients with other NMD. Tongue atrophy was seen in 3/6 patients with LOPD and 6/28 patients with other NMD. CONCLUSION: Tongue abnormalities on brain MRI are common in LOPD compared to other NMD. These abnormalities are not usually reported by the radiologist. Particular attention to the tongue when reviewing brain MRIs may be an important clue for diagnosis of a patient's muscle weakness. A larger study is suggested to evaluate the sensitivity and specificity of tongue abnormalities in patients with LOPD.


Assuntos
Doença de Depósito de Glicogênio Tipo II/diagnóstico por imagem , Doenças Neuromusculares/diagnóstico por imagem , Língua/diagnóstico por imagem , Idade de Início , Feminino , Doença de Depósito de Glicogênio Tipo II/fisiopatologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Doenças Neuromusculares/fisiopatologia , Estudos Retrospectivos , Língua/patologia , Língua/fisiopatologia
18.
Indian J Pathol Microbiol ; 62(3): 454-456, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31361239

RESUMO

Simultaneously triple head and neck malignancies are extremely rare. We report a case who had epithelial and mesenchymal malignant tumor with lymphoid malignancy in head and neck area. A patient who is 74 year old male patient presented to the otorhinolaryngology department with severe breathing difficulty due to laryngeal mass. The result of laryngeal biopsy was invasive SCCs, so patient underwent total larygectomy and bilateral level 2,3,4 neck disection operation. Primary 3 different type head and neck tumors were observed with histopathological examination. These were orderly invasive SCCs in larynx, B-cell Non-Hodgkin's lymphoma in tongue root and one lymph node of left neck dissection material, Kaposi's sarcoma in one lymph node of right neck dissection material. Although synchronous head and neck tumors occurs very rare with laryngeal carcinoma, the neck dissection materials should be researched for synchronous tumors.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Neoplasias Laríngeas/diagnóstico por imagem , Linfoma não Hodgkin/diagnóstico , Neoplasias Primárias Múltiplas/diagnóstico , Sarcoma de Kaposi/diagnóstico , Idoso , Biópsia , Humanos , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/radioterapia , Laringe/patologia , Imagem por Ressonância Magnética , Masculino , Pescoço/patologia , Neoplasias Primárias Múltiplas/patologia , Língua/patologia , Resultado do Tratamento
19.
Otolaryngol Clin North Am ; 52(5): 795-811, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31353141

RESUMO

Ankyloglossia and other oral ties have been recognized for centuries, but interest in and literature on these topics has recently increased. This article presents the latest evidence on the diagnosis and management of tongue-tie and outlines some of the controversies and gaps in the existing evidence. Anterior tongue-tie is accepted in most clinical practices as a potential risk for breastfeeding difficulty, and good evidence exists that division of an anterior tongue-tie leads to improved breastfeeding outcomes. Posterior tongue ties and upper lip-ties are being studied more intensively to provide sound, evidence-based recommendations on their diagnosis and treatment.


Assuntos
Anquiloglossia/cirurgia , Anormalidades da Boca/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Língua/cirurgia , Anquiloglossia/diagnóstico , Aleitamento Materno , Humanos , Lactente , Anormalidades da Boca/diagnóstico , Procedimentos Cirúrgicos Bucais/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto , Língua/patologia
20.
Acta Histochem ; 121(7): 812-822, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31358295

RESUMO

BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose levels. DM affects many body's organs and caused by insulin production deficiency or by the ineffectiveness of the produced insulin. Administration of exogenous insulin is required for management of type I DM; however, it does not cure the disease. Bone marrow-mesenchymal stem cells (BM-MSCs) have been highlighted to offer a novel cell based approach for treatment of diabetes because of their anti-diabetic effect, direct differentiation into a variety of cell types, or release of paracrine factors. AIM: To examine the effect of BM-MSCs versus insulin on true filiform and fungiform papillae of diabetic rats. MATERIALS AND METHODS: Fifty six male Wistar albino rats weighing 200-250 g were equally divided into: Control group (Gp I): Rats did not receive any drug. Diabetic group (Gp II): Rats received a single intra-peritoneal injection of streptozotocin (40 mg/kg). BM-MSCs treated diabetic group (Gp III): After DM confirmation; rats received a single intravenous injection of BM-MSCs (million units) through tail vein. Insulin treated diabetic group (Gp IV): After DM confirmation; rats received a daily subcutaneous injection of insulin (5IU/kg). After four weeks, half of the tongue specimens were processed and stained by Hematoxyline & Eosin and Anti-proliferating cell nuclear antigen (Anti-PCNA) then examined by light microscope. Fluorescent microscope was used to detect homing of injected labeled BM-MSCs in rats' filiform and fungiform papillae. While the other half were examined by scanning electron microscope. RESULTS: True filiform and fungiform papillae of Gp II showed significant histological and morphological alterations. In treated groups, Gp III and Gp IV, both papillae showed marked improvements, being more noticeable in Gp IV. There was a significant increase in the number of Anti-PCNA positive cells and a significant decrease in fasting blood glucose level in Gp III and Gp IV in comparison to Gp II. CONCLUSIONS: DM had degenerative effects on true filiform and fungiform papillae. Administration of BM-MSCs reduced the deleterious effects of DM on both papillae. Insulin injection caused more obvious improvements in both papillae of diabetic rats than BM-MSCs.


Assuntos
Células da Medula Óssea , Diabetes Mellitus Experimental , Insulina/farmacologia , Células-Tronco Mesenquimais , Língua , Animais , Células da Medula Óssea/metabolismo , Células da Medula Óssea/patologia , Diabetes Mellitus Experimental/tratamento farmacológico , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/patologia , Masculino , Células-Tronco Mesenquimais/metabolismo , Células-Tronco Mesenquimais/patologia , Ratos , Ratos Wistar , Língua/metabolismo , Língua/patologia
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