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1.
Medicine (Baltimore) ; 99(2): e18578, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31914037

RESUMO

BACKGROUND: Bibliometric analysis highlights the key topics and research trends which have shaped the understanding and management of a concerned disease. The objective of this study was to identify and characterize the most-cited articles on oral lichen planus (OLP), and highlight the analysis of key topics and research trends. METHODS: A comprehensive search was performed and identified in the Scopus database from 1907 to 5 March 2019 for the top-100 most-cited articles on OLP. RESULTS: The number of citations of the 100 selected articles varied from 101 to 570, with a mean of 178.7 citations per article. Malignant potential, immunopathogenesis, and topical drug therapy were the top-3 study topics, and the majority of high-quality articles were the research of the 3 topics. Journal of Oral Pathology and Medicine (n = 19) and Oral Surgery Oral Medicine Oral Pathology Oral Radiology (n = 14) were 2 journals with the most articles published. Both van der Waal I. and Scully C. were the most frequently contributing authors (n = 9). United States (n = 27) and Academic Centre for Dentistry Amsterdam (n = 7) was the most contributing country and institution, respectively. Systematic reviews (n = 2), randomized controlled trial (n = 1), cohort studies (n = 17) were study designs with higher evidence level, but the large majority (n = 80) were considered lower level. CONCLUSIONS: The results of this first citation analysis of the 100 most cited articles on OLP provide a historical perspective on scientific evolution, and suggest further research trends and clinical practice in the field of OLP.


Assuntos
Bibliometria , Líquen Plano Bucal/tratamento farmacológico , Líquen Plano Bucal/fisiopatologia , Publicações Periódicas como Assunto/tendências , Algoritmos , Autoria , Humanos , Fator de Impacto de Revistas
2.
Medicine (Baltimore) ; 97(50): e13630, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30558050

RESUMO

RATIONALE: Biopsy is very important for the diagnosis of oral lichen planus (OLP) on the lips. Traditional Chinese medicine (TCM) can be used to coordinate the whole body, soften and eliminate swellings and masses, and regulate the functions of qi and blood. Therefore, TCM could be an effective and safe treatment for OLP. Wet dressing is particularly important for the treatment of lip diseases. We report on a rare case of OLP on the lower lip. PATIENT CONCERNS: A 38-year-old female patient presenting with a history of recurrent erosion, bleeding, and pain on her lower lip for 10 years. DIAGNOSES: Erosive OLP of the lower lip. INTERVENTIONS: The patient was treated for 4 months using TCM comprising "Qingwen Jiedu Kouyankang granules," total Paeonia glucosides, and a combination of hormones and anti-inflammatory agents applied locally using a wet dressing. OUTCOMES: Lip erosion was improved remarkably after 1 month, and there was no recurrence or aggravation of the condition. The duration of the follow-up period was 5 months. LESSONS: The therapeutics used here were effective and safe for the treatment of OLP and could improve the quality of life in patients with lip erosion. The therapeutics provide new insight into the treatment of OLP on the lip.


Assuntos
Bandagens , Glucosídeos/administração & dosagem , Líquen Plano Bucal , Lábio , Medicina Tradicional Chinesa/métodos , Paeonia , Adulto , Biópsia/métodos , Medicamentos de Ervas Chinesas/administração & dosagem , Feminino , Humanos , Líquen Plano Bucal/patologia , Líquen Plano Bucal/fisiopatologia , Líquen Plano Bucal/terapia , Lábio/efeitos dos fármacos , Lábio/patologia , Compostos Fitoquímicos/administração & dosagem , Qi , Resultado do Tratamento
3.
Biomed Res Int ; 2018: 5187549, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29992150

RESUMO

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, which manifests as a succession of outbreaks. OLP was associated with salivary oxidative stress. Randomized, double blind, parallel-group study was performed. The sample consisted of 55 clinically and histopathologically diagnosed OLP patients. Twenty-six patients were treated with 2% Chamaemelum nobile gel and 29 with a placebo. Nonstimulated (basal) saliva was collected on the first day of the study and 4 weeks later. Salivary total antioxidant status (TAS) was evaluated by four different methods: two TAC (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) equivalent antioxidant capacity methods (TAC1 and TAC2), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing ability of plasma (FRAP). At baseline (T1), no statistically significant differences were detected in any of the TAS analytes between the two groups of patients. After four weeks of treatment, a statistically significant increase was detected in FRAP in the placebo group (0.323 [0.090-0.467] versus 0.406 [0.197-0.848] mmol/g⁎10-3) (P < 0.05). Significant correlations were observed between pain and drainage and TAC1, CUPRAC, and FRAP and between xerostomia and the TAC1, TAC2, CUPRAC, and FRAP. The results of the present study showed that in patients with OLP increases of TAS in saliva are associated with increase in pain and xerostomia and decrease in drainage, suggesting a worsening condition of the patient. The use of Chamaemelum nobile gel would be recommended for disease stabilization.


Assuntos
Antioxidantes/metabolismo , Chamaemelum , Líquen Plano Bucal/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Estudos de Casos e Controles , Método Duplo-Cego , Humanos , Líquen Plano Bucal/fisiopatologia , Saliva/metabolismo
4.
Skinmed ; 16(1): 19-22, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29551106

RESUMO

Patients with oral lichen planus (OLP) may develop immune sialadenitis that causes a dry mouth. The role of cortisol in autoimmune diseases is well known; yet studies on this subject are controversial. In this study, the salivary flow rate and salivary cortisol level were compared among subtypes of OLP. This study involved three groups of patients: (1) 11 with reticular OLP, (2) 20 with atrophic-erosive OLP, and (3) 30 with no apparent oral lesion. The salivary flow rate in the control group was significantly higher than in OLP patients. The mean level of cortisol in atrophic-erosive cases was higher than in reticular cases and in the control group; however, there was no significant difference between the three study groups. In a previous study, there was moderate to severe acinar atrophy in two-thirds of patients with OLP, which may explain the decreased salivary flow rate in these patients.


Assuntos
Hidrocortisona/metabolismo , Líquen Plano Bucal/metabolismo , Saliva/metabolismo , Adulto , Biomarcadores/metabolismo , Estudos de Casos e Controles , Feminino , Humanos , Líquen Plano Bucal/fisiopatologia , Masculino , Pessoa de Meia-Idade , Taxa Secretória
5.
Sci Rep ; 8(1): 763, 2018 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-29335479

RESUMO

The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues. In addition, vitamin D/VDR signaling inhibited LPS-induced p53-upregulated modulator of apoptosis (PUMA) induction in keratinocytes via impeding nuclear factor-κB (NF-κB) activation, resulting in keratinocytes apoptosis reduction. Importantly, PUMA activity was up-regulated strongly in diseased epithelium, reversely correlated with VDR expression. Totally, our data indicate that LPS is responsible for VDR downregulation in oral keratinocytes, which is associated with OLP development.


Assuntos
Queratinócitos/efeitos dos fármacos , Queratinócitos/metabolismo , Líquen Plano Bucal/fisiopatologia , Lipopolissacarídeos/metabolismo , Receptores de Calcitriol/análise , Adulto , Idoso , Células Cultivadas , Feminino , Humanos , Masculino , MicroRNAs/metabolismo , Pessoa de Meia-Idade , Transdução de Sinais , Fator de Necrose Tumoral alfa/metabolismo
6.
J Appl Oral Sci ; 26: e20170146, 2018 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-29364344

RESUMO

Oral lichen planus (OLP) is a chronic, multifocal, sometimes painful, inflammatory disease of the oral mucosa. OLP can predispose development of psycho-emotional disorders. Until now, the relationship between the severity of lichen planus and the psychological profile of patients (psychological well-being, perceived stress and pain coping strategies) has never been studied. Study was conducted on 42 OLP patients. Number of sites involved, severity and activity score of OLP were evaluated. Psychological tests were used to evaluate patients' psycho-emotional condition. The mean duration time of symptomatic OLP was 43 months. We detected that the longer the duration of subjective symptoms, the poorer the quality of life and the higher the level of perceived stress (PSS). Also, the higher the PSS results, the greater the anxiety and depression on Hospital Anxiety and Depression Scale (HADS). Likewise, higher level of depression in HADS was strongly correlated with worse quality of life. (p≤0.05). In this study, we detected a relationship between duration of the disease, level of perceived stress and quality of life. The longer the disease lasts, the higher it tends to catastrophize. This may influence development or increase of the anxiety and depression and may decrease patients' quality of life.


Assuntos
Líquen Plano Bucal/psicologia , Qualidade de Vida/psicologia , Perfil de Impacto da Doença , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Ansiedade/etiologia , Ansiedade/fisiopatologia , Ansiedade/psicologia , Depressão/etiologia , Depressão/fisiopatologia , Depressão/psicologia , Feminino , Humanos , Líquen Plano Bucal/complicações , Líquen Plano Bucal/fisiopatologia , Masculino , Pessoa de Meia-Idade , Medição da Dor , Escalas de Graduação Psiquiátrica , Índice de Gravidade de Doença , Fatores Sexuais , Estatísticas não Paramétricas , Estresse Psicológico , Inquéritos e Questionários , Escala Visual Analógica , Adulto Jovem
7.
J Oral Pathol Med ; 47(1): 60-65, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28766765

RESUMO

BACKGROUND: Oral potentially malignant disorders (OPMDs) could have a significant psychological impact on patients, principally because of the unknown risk of malignant transformation, while the physical and functional impairments could differ. This study aimed to assess the impact of three different OPMDs and their disease stages on the quality of life (QoL) of affected patients. METHODS: Oral leukoplakia (OL), oral lichen planus (OLP) and oral submucous fibrosis (OSF) patients who were undergoing treatment at an oral medicine clinic of a dental teaching hospital in India were the study population. All subjects completed the recently developed OPMDQoL questionnaire and a short form 12 item (version 2) health survey questionnaire (SF-12v2). OPMDQoL questionnaire consists of 20 items over four dimensions. A higher score denotes poor OHRQoL. SF-12v2 has two components, a Physical Component Summary (PCS) and Mental Component Summary (MCS). RESULTS: A total of 150 subjects (50 each of OL, OLP and OSF) participated. OL patients (37.7 ± 7.9) reported significantly better OPMDQoL scores than OLP (47.3 ± 5.8) and OSF (45.4 ± 9.2) patients. OLP patients reported significant problems in obtaining a clear diagnosis for their condition, more so than the other OPMDs. OL patients reported fewer problems for the dimension, "physical impairment and functional limitations" than the OLP and OSF patients. A significant trend was observed with the overall OPMDQoL and MCS, deteriorating as the disease stage increased. CONCLUSIONS: OLP and OSF have a significant impact on the QoL of affected individuals: OL less so. Increasing stage of the disease is associated with worsening QoL.


Assuntos
Transformação Celular Neoplásica , Doenças da Boca/fisiopatologia , Doenças da Boca/psicologia , Neoplasias Bucais/fisiopatologia , Neoplasias Bucais/psicologia , Qualidade de Vida , Atividades Cotidianas , Adulto , Inquéritos de Saúde Bucal , Feminino , Humanos , Índia , Leucoplasia Oral/fisiopatologia , Leucoplasia Oral/psicologia , Líquen Plano Bucal/fisiopatologia , Líquen Plano Bucal/psicologia , Masculino , Doenças da Boca/terapia , Neoplasias Bucais/terapia , Saúde Bucal , Fibrose Oral Submucosa/fisiopatologia , Fibrose Oral Submucosa/psicologia , Inquéritos e Questionários
8.
Braz Dent J ; 28(6): 699-703, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29211124

RESUMO

Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls. The P-wave durations (Pmax and Pmin) were calculated in all 12 leads. The difference between Pmax and Pmin was defined as P-Wave Dispersion (PWD). After the PWD was recorded, the results were statistically analyzed. The study showed that PWD increased on surface ECG measurements in OLP patients who were otherwise asymptomatic in relation to cardiac conditions. The p value obtained was <0.001 which was highly significant. The present study suggests a highly statistically significant association of OLP with increased P-wave dispersion. Hence the patients with OLP should undergo cardiac evaluation and follow up for early detection of atrial fibrillation.


Assuntos
Eletrocardiografia/métodos , Líquen Plano Bucal/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
9.
Artigo em Inglês | MEDLINE | ID: mdl-29264897

RESUMO

BACKGROUND: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines play a key role in lichen planus pathogenesis. This study investigates the relationship between disease severity and levels of tumor necrosis factor-α (TNF-α), which is considered a primary cytokine that initiates cytotoxicity. MATERIAL AND METHODS: Serum TNF-α levels were compared between a patient group (n = 34) and a control group (n = 20). TNF-α serum levels were measured using human TNF-α Enzyme-Linked Immunosorbent Assay (ELISA) test kits, and the two groups were statistically compared to each other. RESULTS: Mean serum TNF-α levels were found to be significantly higher in the patient group than in the control group (p < 0.005). However, no significant association was observed between TNF-α levels and oral mucosal involvement (p > 0.005). No relationship was detected between TNF-α levels and patients' sex. CONCLUSION: It is thought that TNF-α, a proinflammatory cytokine, may play an important role in the pathogenesis of lichen planus. TNF-α may be a simple and effective predictor to illustrate the inflammatory status in patients with lichen planus.


Assuntos
Líquen Plano/imunologia , Líquen Plano/fisiopatologia , Índice de Gravidade de Doença , Fator de Necrose Tumoral alfa/sangue , Biomarcadores/sangue , Estudos de Casos e Controles , Feminino , Humanos , Mediadores da Inflamação/imunologia , Líquen Plano Bucal/imunologia , Líquen Plano Bucal/fisiopatologia , Masculino , Prognóstico , Estudos Retrospectivos , Fator de Necrose Tumoral alfa/metabolismo
10.
Braz. dent. j ; 28(6): 699-703, Nov.-Dec. 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-888703

RESUMO

Abstract Lichen planus (LP) is considered to be a T-cell-mediated inflammatory disorder. Inflammation is considered to produce disturbances of lipid metabolism which may affect the myocardium. Increased P-Wave Dispersion (PWD) is demonstrated as an independent risk factor for developing atrial fibrillation (AF). Hence the present study has been conducted to explore the possible relationship of oral lichen planus (OLP) with AF by the evaluation of PWD. Twelve-lead electrocardiographs (ECG) were obtained from 45 OLP patients and 45 age and gender-matched healthy controls. The P-wave durations (Pmax and Pmin) were calculated in all 12 leads. The difference between Pmax and Pmin was defined as P-Wave Dispersion (PWD). After the PWD was recorded, the results were statistically analyzed. The study showed that PWD increased on surface ECG measurements in OLP patients who were otherwise asymptomatic in relation to cardiac conditions. The p value obtained was <0.001 which was highly significant. The present study suggests a highly statistically significant association of OLP with increased P-wave dispersion. Hence the patients with OLP should undergo cardiac evaluation and follow up for early detection of atrial fibrillation.


Resumo O líquen plano oral (LPO) é considerado um distúrbio inflamatório mediado por células T. Acredita-se que a inflamação produza distúrbios do metabolismo lipídico que podem afetar o miocárdio. Uma dispersão de onda-P (DOP) aumentada é demonstrada como um fator de risco independente para o desenvolvimento de fibrilação atrial. Assim, o presente estudo foi conduzido para explorar a possível relação de LPO com fibrilação atrial pela avaliação por meio de DOP. Eletrocardiogramas (ECG) de 12 derivações foram obtidos de 45 pacientes com LPO e 45 controles saudáveis com idade e sexo equiparados. As durações das ondas P (Pmax e Pmin) foram calculadas em todas as 12 derivações. A diferença entre Pmax e Pmin foi definida como DOP e os valores analisados estatisticamente. O estudo mostrou que DOP aumentada nos ECG de superfície dos pacientes com OLP que eram assintomáticos em relação a condições cardíacas. O valor p obtido foi <0,001, altamente significativo. O presente estudo sugere uma associação altamente significativa estatisticamente entre OLP a DOP aumentada. Assim, os pacientes com OLP devem ser submetidos a avaliação cardíaca e acompanhamento para detecção precoce da fibrilação atrial.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Eletrocardiografia/métodos , Líquen Plano Bucal/fisiopatologia
11.
Rev. Ateneo Argent. Odontol ; 56(1): 25-30, jun. 2017.
Artigo em Espanhol | LILACS | ID: biblio-869404

RESUMO

En los últimos años se han producido grandes avances en el diagnóstico y tratamiento del Liquen Plano Oral (LPO). Sin embargo, sigue siendo una entidad con muchos interrogantes para la estomatología, sobre todo referidos a su proceso de aparición y a su tratamiento. El propósito de este trabajo es realizar una revisión bibliográfica actualizada del LPO y su relación con la apoptosis, tema de gran interés para la investigación científica. La apoptosis por su parte adquiere gran relevancia debido al rol que cumple este mecanismo: regulación en la morfogénesis, homeostasis de las poblaciones celulares y carcinogénesis en relación a la tendencia y potencial capacidad de transformación maligna de algunas variantes de LPO en sus formas atípicas.


In recent years, there have been major advances in the diagnosis and treatment of Oral Lichen Planus (OLP). However, it remains an entity with many questions for stomatology, especially referred to the process of occurrence and treatment. The purpose of this work is to conduct a literature review updated LPO and its relationship with apoptosis, topic of great interest for scientific research. The apoptosis meanwhile acquires great importance because of the role that this mechanism regulating morphogenesis, homeostasis of cell populations and carcinogenesis in relation to the trend and potential ability of malignant transformation of some variants of LPO in their atypical forms.


Assuntos
Humanos , Apoptose/fisiologia , Transformação Celular Neoplásica , Líquen Plano Bucal/etiologia , Líquen Plano Bucal/fisiopatologia , Marcação In Situ das Extremidades Cortadas/métodos , Imuno-Histoquímica/métodos , Lesões Pré-Cancerosas/classificação , Lesões Pré-Cancerosas/complicações
12.
Acta Derm Venereol ; 97(2): 214-218, 2017 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-27599552

RESUMO

Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.


Assuntos
Diferenciação Celular , Epitélio/fisiopatologia , Doenças dos Genitais Femininos/fisiopatologia , Doenças dos Genitais Masculinos/fisiopatologia , Líquen Plano Bucal/fisiopatologia , Mucosa Bucal/fisiopatologia , Proteínas 14-3-3/análise , Proteínas 14-3-3/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Proteínas de Transporte/análise , Proteínas de Transporte/genética , Estudos de Casos e Controles , Proteínas do Citoesqueleto , Exorribonucleases/análise , Exorribonucleases/genética , Feminino , Doenças dos Genitais Femininos/patologia , Doenças dos Genitais Masculinos/patologia , Humanos , Proteínas Inibidoras de Diferenciação/análise , Proteínas Inibidoras de Diferenciação/genética , Líquen Plano Bucal/patologia , Masculino , Proteínas de Membrana/análise , Proteínas de Membrana/genética , Pessoa de Meia-Idade , Mucosa Bucal/química , Mucosa Bucal/patologia , Proteínas de Neoplasias/análise , Proteínas de Neoplasias/genética , RNA Mensageiro/análise , Receptores de Superfície Celular/análise , Receptores de Superfície Celular/genética
13.
Oral Dis ; 23(4): 471-476, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28028908

RESUMO

BACKGROUND: The amalgam-associated oral lichenoid lesion (AAOLL) shows clinical and histopathological features similar to oral lichen planus (OLP). Molecular researches to improve knowledge of pathogenesis and clinical behavior of AAOLL are still scarce. OBJECTIVE: We investigated for the first time the use of loss of heterozygosity (LOH) as a molecular approach for genetic characterization of AAOLL in comparison with OLP and evaluated the cell proliferation index. MATERIALS AND METHODS: The sample comprised nine AAOLLs, 10 OLPs, and eight NOMs matched by patients' gender and age. LOH was assessed using polymorphic microsatellite markers at chromosomes 9p (D9S157, D9S162, D9S171), 11q (D11S1369), and 17p (TP53, AFM238WF2). Cell proliferation was assessed by immunohistochemical expression of Ki-67 (MIB-1). The association between LOH and Ki-67 was investigated. RESULTS: Loss of heterozygosity occurred in 5/9 AAOLLs and in 2/10 OLPs in at least one marker each, while NOM showed no LOH. Cell proliferation index in AAOLL ranged from 2 to 23%. There was no association between cell proliferation and LOH, independent of the marker. CONCLUSION: Our study shows that the profile of molecular changes in AAOLL and OLP, evaluated by LOH and Ki-67 expression, is similar. Additional studies including larger samples should be performed to confirm or to refute our findings.


Assuntos
Amálgama Dentário/efeitos adversos , Erupções Liquenoides/etiologia , Perda de Heterozigosidade , Doenças da Boca/etiologia , Mucosa Bucal/fisiopatologia , Adulto , Idoso , Estudos de Casos e Controles , Proliferação de Células , Feminino , Humanos , Imuno-Histoquímica , Antígeno Ki-67/metabolismo , Líquen Plano Bucal/genética , Líquen Plano Bucal/fisiopatologia , Erupções Liquenoides/genética , Erupções Liquenoides/fisiopatologia , Masculino , Repetições de Microssatélites , Pessoa de Meia-Idade , Doenças da Boca/genética , Doenças da Boca/fisiopatologia , Polimorfismo Genético
14.
Clin Oral Investig ; 21(3): 957-964, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27270904

RESUMO

OBJECTIVES: The aim of the study was to evaluate if patients with oral lichen planus (OLP) and tongue involvement have impaired taste function and if there is an association to the perception of pain. MATERIAL AND METHODS: The test group included patients with OLP and involvement of the tongue without treatment (n = 20). Control subjects had no mucosal or systemic disease affecting taste function and were matched for age and gender (n = 20). Patients' intraoral pain and subjective perception of taste were recorded on a visual analog scale. Taste function was assessed by means of the "taste strips." RESULTS: Measured taste function was slightly but significantly decreased in OLP patients compared to control subjects (p = 0.01). Self-rated taste perception did not differ in both groups (p = 0.8). Post hoc analysis showed that particularly the taste quality "sour" was most affected by the OLP status (p = 0.01). There were no correlations between pain and subjective/objective taste perception. CONCLUSION: Untreated OLP subjects have lower gustatory function, which they are not aware of. CLINICAL RELEVANCE: Impaired gustatory function in patients with OLP may affect patient's quality of life. Further studies on larger samples sizes are requested.


Assuntos
Líquen Plano Bucal/fisiopatologia , Percepção Gustatória/fisiologia , Língua/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Estudos Prospectivos , Qualidade de Vida
15.
J Physiol Pharmacol ; 67(6): 885-894, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28195069

RESUMO

Reactive oxygen species (ROS) are involved in the pathogenesis of many inflammatory diseases, including oral lichen planus. Therefore, determining the salivary markers of oxidative stress is an excellent alternative approach to diagnosing oral cavity diseases. The objective of our study was to provide preliminary validation and determination of the salivary markers of oxidative stress in both patients with reticular and erosive forms of oral lichen planus as well as in healthy individuals without any oral lesions. In total, 62 patients with oral lichen planus (OLP) were enrolled in the study, including 31 with the reticular form of lichen planus (44.63 ± 11.05 years) and 31 with erosive forms (40.43 ± 10.05 years), who had never been treated for their disease. The control group comprised 30 individuals without any oral lesions (42.12 ± 12.22 years). We determined the saliva levels in glutathione (GSH), total antioxidant capacity (TAC), and thiobarbituric acid reactive substances (TBARS). The mean saliva levels of GSH and TAC were significantly lower (P < 0.01) in OLP patients compared to the control group. The mean levels of salivary TBARS were higher in both OLP groups (reticular and erosive) compared to the control group (P = 0.01). The lower saliva levels of GSH and TAC in patients with OLP indicate that free radicals and the resulting oxidative damage may play an important role in the pathogenesis of OLP lesions. In conclusion, monitoring the oxidant-antioxidant status of saliva may serve as an efficient and less intrusive marker for determining stages of disease development in patients with OLP.


Assuntos
Líquen Plano Bucal/metabolismo , Líquen Plano Bucal/fisiopatologia , Estresse Oxidativo/fisiologia , Saliva/metabolismo , Saliva/fisiologia , Adulto , Antioxidantes/metabolismo , Biomarcadores/metabolismo , Estudos de Casos e Controles , Feminino , Glutationa/metabolismo , Humanos , Masculino , Malondialdeído/metabolismo , Pessoa de Meia-Idade , Oxirredução , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
16.
J Oral Rehabil ; 43(5): 388-99, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26685871

RESUMO

To reveal dental implants survival rates in patients with oral mucosal diseases: oral lichen planus (OLP), Sjögren's syndrome (SjS), epidermolysis bullosa (EB) and systemic sclerosis (SSc). A systematic literature search using PubMed/Medline and Embase databases, utilising MeSH and search term combinations identified publications on clinical use implant-prosthetic rehabilitation in patients with OLP, SjS, EB, SSc reporting on study design, number, gender and age of patients, follow-up period exceeding 12 months, implant survival rate, published in English between 1980 and May 2015. After a mean observation period (mOP) of 53·9 months (standard deviation [SD] ±18·3), 191 implants in 57 patients with OLP showed a survival rate (SR) of 95·3% (SD ±21·2). For 17 patients with SjS (121 implants, mOP 48·6 ± 28·7 months), 28 patients with EB (165 implants, mOP 38·3 ± 16·9 months) and five patients with SSc (38 implants, mOP 38·3 ± 16·9 months), the respective SR was 91·7 ± 5·97% (SjS), 98·5 ± 2·7% (EB) and 97·4 ± 4·8% (SSc). Heterogeneity of data structure and quality of reporting outcomes did not allow for further comparative data analysis. For implant-prosthetic rehabilitation of patients suffering from OLP, SjS, EB and SSc, no evidence-based treatment guidelines are presently available. However, no strict contraindication for the placement of implants seems to be justified in patients with OLP, SjS, EB nor SSc. Implant survival rates are comparable to those of patients without oral mucosal diseases. Treatment guidelines as for dental implantation in patients with healthy oral mucosa should be followed.


Assuntos
Implantação Dentária Endo-Óssea/métodos , Epidermólise Bolhosa/cirurgia , Líquen Plano Bucal/cirurgia , Doenças da Boca/cirurgia , Mucosa Bucal/patologia , Escleroderma Sistêmico/cirurgia , Síndrome de Sjogren/cirurgia , Implantes Dentários , Epidermólise Bolhosa/fisiopatologia , Humanos , Líquen Plano Bucal/fisiopatologia , Doenças da Boca/fisiopatologia , Escleroderma Sistêmico/fisiopatologia , Síndrome de Sjogren/fisiopatologia , Resultado do Tratamento
17.
Med. clín (Ed. impr.) ; 145(9): 404-408, nov. 2015.
Artigo em Espanhol | IBECS | ID: ibc-142969

RESUMO

Se revisa el concepto de lesiones precancerosas orales, de cáncer oral y su diagnóstico precoz. Con las palabras clave: premalignant oral lesions prevention se realiza una búsqueda de los 10 últimos años. También se buscan los ensayos clínicos desde enero de 2011 hasta la actualidad con las palabras clave: oral cancer prevention AND dentistry. Se destaca que no hay cambios significativos relacionados con el concepto de lesión precancerosa y cáncer, y que en cuanto al diagnóstico precoz, si bien se describen numerosos métodos de cribado, la biopsia sigue siendo la prueba más útil y, por tanto, imprescindible, más aún si consideramos las nuevas posibilidades de estudios moleculares (AU)


We reviewed the concept of oral precancerous lesions, oral cancer, and the possibility of early diagnosis. With the keywords: premalignant oral lesions prevention, a search was performed over the past 10 years. Also clinical trials are searched from January 2011 until today with the keywords: oral cancer prevention AND dentistry. It is emphasized that there can be no significant changes related to the concept of precancerous lesions and cancer, and those relating to the early diagnosis. Despite the numerous described methods of screening, biopsy remains the most useful test, and therefore it is essential, mainly if we consider the new possibilities of molecular studies (AU)


Assuntos
Animais , Feminino , Masculino , Camundongos , Lesões Pré-Cancerosas/epidemiologia , Lesões Pré-Cancerosas/veterinária , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/veterinária , Diagnóstico Precoce , Líquen Plano Bucal/diagnóstico , Líquen Plano Bucal/patologia , Modelos Animais , Programas de Rastreamento/métodos , Biópsia/métodos , Biópsia , Líquen Plano Bucal/fisiopatologia , Líquen Plano Bucal , Líquen Plano Bucal/veterinária
18.
J Contemp Dent Pract ; 16(5): 400-6, 2015 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-26162261

RESUMO

OBJECTIVE: To determine whether dental implants impress oral lesions, and to evaluate the nature of their effect on the lesions. MATERIALS AND METHODS: A comprehensive search was done via Google and PubMed for articles (including case reports and literature reviews) containing the keywords 'oral squamous cell carcinoma' (OSCC), 'oral lichen planus' (OLP), 'lichenoid contact reaction' (LCR), 'osseointegrated implants', and 'dental implants' , in the last 10 years (2002-2012). RESULTS: The study included 24 articles involving patients with dental implants, and some oral lesions (e.g. oral lichen planus and oral squamous cell carcinoma) or with a history of lesions. In these publications, there is evidence suggesting the possibility of emergence, exacerbation, recurrence, or even malignant transformation of the oral lesions after implant placement in some cases. CONCLUSION: Based on our review of the literature, implant treatment does not seem to be completely safe under any circumstances, but may have some complications in subjects with certain diseases (e.g. oral lesions, autoimmune diseases, malignancies, allergic reactions, etc.). Therefore prior to treatment, patients should be fully informed of the risks. CLINICAL SIGNIFICANCE: Implant treatment is best done with caution in patients with cancer or mucocutaneous disorders.


Assuntos
Implantes Dentários , Doenças da Boca/fisiopatologia , Carcinoma de Células Escamosas/fisiopatologia , Implantes Dentários/efeitos adversos , Doenças da Gengiva/fisiopatologia , Humanos , Líquen Plano Bucal/fisiopatologia , Erupções Liquenoides/fisiopatologia , Neoplasias Bucais/fisiopatologia
19.
J Oral Pathol Med ; 44(3): 229-33, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25155153

RESUMO

BACKGROUND: Burning mouth syndrome remains a puzzling condition. One symptom commonly associated with the burning sensation is xerostomia. The current study measured basal and stimulated salivary flow in a group of burning mouth syndrome patients. METHODS: Three groups of patients were recruited: 44 burning mouth syndrome patients, 27 oral lichen planus patients and 40 healthy patients. We chose to measure basal salivary flow and stimulated salivary flow in the three groups of patients using the 'spitting' method. Thus, the patients were asked to spit every minute for 5 min. Afterwards, they were asked to repeat the procedure a second time, but a drop of citric acid was positioned on their tongue every minute to stimulate salivary secretion. After 14 days, the same procedure was repeated for 15 min. RESULTS: Although there was no significant difference between the burning mouth syndrome group and the other two groups regarding the stimulated volumes, an important difference was found in the basal volumes, with the burning mouth syndrome patients showing lower values. CONCLUSIONS: The outcomes of our research demonstrate the presence of very low basal salivary flow in burning mouth syndrome patients compared with the other two groups, but the stimulated salivary flow was equal, if not higher, in the burning mouth syndrome patients. This study contributes new topics for further investigation of a solution to the very mysterious pathology represented by burning mouth syndrome.


Assuntos
Síndrome da Ardência Bucal/fisiopatologia , Saliva/metabolismo , Taxa Secretória/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Ácido Cítrico/farmacologia , Feminino , Seguimentos , Humanos , Líquen Plano Bucal/fisiopatologia , Masculino , Pessoa de Meia-Idade , Saliva/efeitos dos fármacos , Taxa Secretória/efeitos dos fármacos
20.
J Oral Maxillofac Surg ; 72(8): 1517-22, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25037185

RESUMO

PURPOSE: To compare oral health-related quality of life (OHRQoL) of patients with oral lichen planus (OLP), oral leukoplakia (OL), or oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Seventy-three patients with OLP, 44 with OL, and 37 with OSCC participated in this prospective study. The German version of the 14-item Oral Health Impact Profile (OHIP-G 14) was used to measure OHRQoL. Descriptive statistics and multivariate analysis of clinical forms, age, gender, alcohol consumption, and smoking habits were evaluated. RESULTS: No association to cumulative OHIP-14 score (P = .086) among the 3 groups was found. However, patients with OLP showed a higher "physical pain" score and a lower "social disability" score (P = .026) than patients with OSCC, followed by patients with OL. Women with OLP had a lower OHRQoL than men. After differentiation of clinical forms of OLP (symptomatic vs asymptomatic), an impact on these patients' OHRQoL in the dimensions "physical pain" and "physical disability" was found. CONCLUSION: Patients with OLP or OSCC and high OHIP-G 14 scores reported physical pain, which emphasizes the need for physical therapy. For improved OHRQoL, patients with symptomatic forms of OLP would gain more from a treatment compared with those with asymptomatic forms. In contrast, patients with asymptomatic OLP or OL and thus with a minimal impact on their OHRQoL might be at risk of delayed consultation, diagnosis, and treatment of their condition.


Assuntos
Carcinoma de Células Escamosas/fisiopatologia , Leucoplasia Oral/fisiopatologia , Líquen Plano Bucal/fisiopatologia , Neoplasias Bucais/fisiopatologia , Saúde Bucal , Qualidade de Vida , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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