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1.
Turkiye Parazitol Derg ; 43(4): 165-169, 2019 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-31865650

RESUMO

Objective: Although the disease has been eliminated in Turkey malaria continues to be a threat due to increase in the number of people coming from or going to countries where the disease is endemic. In this study, we aimed to evaluate blood smears sent to the National Malaria Reference Laboratory within the malaria surveillance system. Methods: From March 2016 to July 2018 a retrospective study was conducted to compare the results of Malaria Reference Laboratory and Public Health Laboratories. A total of 16.827 blood stains were sent to our laboratory for approval. Results: In Public Health Laboratories, 315 (1.88%) of the smears were positive, 16.510 (98.12%) were negative, and in the National Malaria Reference Laboratory 252 (1.50%) were positive, 16.466 were negative. In the Public Health Laboratories, one of the two samples considered to be malaria suspected was positive in the National Malaria Reference Laboratory and one was negative. In Public Health Laboratories 35.88% of smears were P. falciparum, 27.30% were Plasmodium spp., 20.96% were P. vivax, 14.92% were mixed infection, 0.63% were P. malariae, 0.31% were P. ovale, and in the Reference Laboratory 49.60% were Plasmodium spp., 29.37% were P. falciparum, 16.27% were P. vivax, 4.36% were mixed infection, 0.40% were P. malariae. Conclusion: In order to malaria surveillance system to be maintained in a healthy manner, preparation, staining, coding, packaging, transportation of blood slides is very important. Also if necessary, continuing training of laboratory staff working in malaria diagnosis is crucial.


Assuntos
Laboratórios/normas , Malária/sangue , Humanos , Laboratórios/classificação , Malária/diagnóstico , Malária/epidemiologia , Malária/parasitologia , Malária Falciparum/sangue , Malária Falciparum/epidemiologia , Malária Vivax/sangue , Malária Vivax/epidemiologia , Masculino , Plasmodium/isolamento & purificação , Plasmodium falciparum/isolamento & purificação , Plasmodium malariae/isolamento & purificação , Plasmodium ovale/isolamento & purificação , Plasmodium vivax/isolamento & purificação , Saúde Pública , Estudos Retrospectivos , Manejo de Espécimes/normas , Viagem , Turquia/epidemiologia
2.
Health Secur ; 17(5): 372-383, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31593511

RESUMO

Laboratory-acquired infections (LAIs), an occupational illness, are defined as all infections acquired through laboratory or laboratory-related activities. A report published in 1898 described an LAI resulting from Corynebacterium diphtheriae being transmitted through mouth pipetting. Despite all efforts, LAIs continue, especially in developing countries like Pakistan, which has been fighting to curb many infectious diseases. As reflected in the published literature, the biosafety culture is severely lacking in many laboratories, and there are no data available from Pakistan on LAIs. Our objective was to ascertain the frequency and rate of LAIs in various labs with versatile portfolios in relation to biosafety and biosecurity practices in Karachi. Ours is a descriptive multicenter cross-sectional study conducted in 30 laboratories located in Karachi from November 2017 to April 2018. Data were collected from laboratories including the university hospital labs, research labs, animal labs, and biomedical labs. Out of 30 facilities, half (n = 15) were clinical/biomedical laboratories, 16.6% (n = 5) were university hospital laboratories, 26.6% (n = 8) were R&D laboratories, and 6.6% (n = 2) were animal laboratories. Needle stick was found to be the most common injury, followed by animal bite/scratch, cut on mucous membrane, falling of personnel, and burn injury.


Assuntos
Contenção de Riscos Biológicos/métodos , Contenção de Riscos Biológicos/normas , Infecção Laboratorial/epidemiologia , Doenças Profissionais/epidemiologia , Estudos Transversais , Fidelidade a Diretrizes , Guias como Assunto , Humanos , Laboratórios/classificação , Paquistão/epidemiologia , Prevalência , Medição de Risco , Gestão de Riscos , Inquéritos e Questionários
3.
Biomedica ; 39(Supl. 2): 101-116, 2019 08 01.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31529838

RESUMO

Introduction: To reach the goal of malaria elimination in Ecuador for the year 2020, it is necessary to have a laboratory network with the capacity to perform microscopic diagnosis according to the WHO/PAHO quality standards and to provide the adequate treatment of cases. Objective: To determine the level of competence for parasitological diagnosis of the microscopists from the local public network and the performance of intermediate reference laboratories. Materials and methods: We conducted a cross-sectional study based on the information collected in workshops carried out to appraise the competence for microscopic diagnosis of the local laboratory network (zonal health coordinating offices 1 to 8) using a slide panel to evaluate diagnosis agreement, as well as the diagnostic performance of the intermediate laboratories using an external quality assessment program. The results were compared against the reference standards of the supranational laboratory in Perú. Results: We evaluated the competencies of 191 microscopists in 11 workshops and 153 (80.1%) of them were approved. The medians of the indicators were the following: concordance for parasite detection, 100% (Q1- Q3: 96-100), concordance for species identification, 100% (Q1- Q3: 93-100), and concordances for stage identification, 93.0% (Q1- Q3: 86-95) and parasite counting, 77.0% (Q1- Q3: 71-82). In the external quality assessment, the three intermediate laboratories obtained 100% in parasite detection concordance and 96% for species detection concordance. Conclusions: The results for the primary network and the performance indicators for the intermediate laboratories showed the high-quality standards of the training program implemented in the country.


Assuntos
Eritrócitos/parasitologia , Ensaio de Proficiência Laboratorial , Malária Falciparum/diagnóstico , Malária Vivax/diagnóstico , Pessoal de Laboratório Médico/estatística & dados numéricos , Microscopia/métodos , Parasitemia/diagnóstico , Plasmodium falciparum/isolamento & purificação , Plasmodium vivax/isolamento & purificação , Estudos Transversais , Equador , Eritrócitos/ultraestrutura , Feminino , Humanos , Laboratórios/classificação , Laboratórios/normas , Malária Falciparum/sangue , Malária Falciparum/prevenção & controle , Malária Vivax/sangue , Malária Vivax/prevenção & controle , Masculino , Pessoal de Laboratório Médico/educação , Microscopia/normas , Parasitemia/sangue , Parasitemia/prevenção & controle , Prática Profissional/estatística & dados numéricos , Garantia da Qualidade dos Cuidados de Saúde , Fatores Socioeconômicos
4.
Hum Vaccin Immunother ; 15(10): 2264-2268, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30893007

RESUMO

Mobile laboratories provide diagnostic capabilities for routine surveillance and patient identification during an outbreak. In either situation, they face many challenges including identification of the appropriate assay(s) to employ, logistical arrangements, and providing for the health and safety of the laboratory staff. Great strides have been made over the last decade in the development of mobile laboratories with assays that require minimal infrastructure and technical experience. This knowledge and expertise have been developed in partnership with many researchers and public health officials who live in regions prone to infectious disease outbreaks. Mobile laboratories should now also be used in the evaluation of novel vaccines and therapeutics in remote locations. Clinical mobile laboratories will include similar diagnostic capabilities as outbreak response mobile labs, but will also include additional point-of-care instruments operated under Good Clinical Practice guidelines. They will also operate rigorous data management plans so that the data collected will satisfy regulatory agencies during the licensure process. Failure to deploy an adequate clinical mobile laboratory when administering a novel biological product in a remote location is a significant limitation to any collected scientific data that could ultimately undermine clinical development and availability of life-saving interventions.


Assuntos
Surtos de Doenças/prevenção & controle , Laboratórios/classificação , Unidades Móveis de Saúde , Vacinas/imunologia , Técnicas de Laboratório Clínico , Doença pelo Vírus Ebola/diagnóstico , Humanos , Técnicas de Diagnóstico Molecular/normas , Sistemas Automatizados de Assistência Junto ao Leito/normas , Vacinas/normas , Organização Mundial da Saúde
5.
Dev World Bioeth ; 19(3): 148-154, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-30520552

RESUMO

Brazil is the biggest market for pesticides in the world. In the registration process, a pesticide must be authorized by the Institute of the Environment, Health Surveillance Agency and Ministry of Agriculture. Evaluations follow a package of toxicological studies submitted by the companies and also based on the Brazilian law regarding pesticides. We confronted data produced by private laboratories, submitted to the Institute of the Environment for registration, with data obtained from scientific databases, corresponding to mutagenicity, carcinogenicity and teratogenicity of pesticides. All studies submitted by the companies were carried out by private laboratories. From 247 pesticide formulations analyzed, none showed positive results for mutagenicity, carcinogenicity or teratogenicity. From 574 articles in the scientific literature, 84% published by public laboratories showed positive results, while 79% of those showing negative results came from private laboratories. There is an ethical concern about a conflict of interest between public/independent laboratories and private laboratories that produce data for registering pesticides. We demonstrated that there is a clear contradiction between public and private laboratories. Brazilian regulatory authorities have approved the registration of pesticides based almost exclusively on the monographs provided by the pesticide industry, because the use of scientific articles or information from the independent literature is strongly belittled by the industry. Pesticide companies argue that scientific articles cannot be trusted. Also, according to the industry, pesticide registration cannot be refused based on results from scientific articles. Thus, the registration of pesticides with mutagenic, carcinogenic and teratogenic risks has been approved in Brazil.


Assuntos
Carcinógenos/toxicidade , Conflito de Interesses , Regulamentação Governamental , Mutagênicos/toxicidade , Praguicidas/classificação , Praguicidas/toxicidade , Teratogênios/toxicidade , Brasil/epidemiologia , Humanos , Laboratórios/classificação , Setor Privado , Setor Público
6.
J Clin Microbiol ; 56(8)2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29875196

RESUMO

In the United States, the gold standard for malaria diagnosis is microscopic blood smear examination. Because malaria is not endemic in the United States, diagnostic capabilities may be limited, causing delays in diagnosis and increased morbidity and mortality. A survey of the malaria diagnostic practices of U.S. laboratories was conducted from June to July 2017; members of the American Society for Microbiology's listserv received a questionnaire inquiring about malaria diagnostic test availability, techniques, and reporting. Results were assessed using the Clinical and Laboratory Standards Institute (CLSI) guidelines for malaria diagnostics. After excluding incomplete and duplicate responses, responses representing 175 laboratories were included. Most labs (99%) received at least one specimen annually for malaria diagnosis, and 31% reported receiving only 1 to 10 specimens. The majority (74%) diagnosed five or fewer cases of malaria per year. Most (90%) performed blood smears on-site. Two-thirds (70%) provided initial blood smear results within 4 h. Although diagnostic testing for malaria was available 24/7 at 74% (141) of responding laboratories, only 12% (17) met criteria for analysis and reporting of malaria testing, significantly more than reported in a similar survey in 2010 (3%; P < 0.05). The majority of laboratories surveyed had the capability for timely diagnosis of malaria; few comply with CLSI guidelines. Inexperience may factor into this noncompliance; many laboratories see few to no cases of malaria per year. Although reported adherence to CLSI guidelines was higher than in 2010, there is a need to further improve laboratory compliance with recommendations.


Assuntos
Fidelidade a Diretrizes/estatística & dados numéricos , Laboratórios/estatística & dados numéricos , Malária/diagnóstico , Serviços de Laboratório Clínico/normas , Serviços de Laboratório Clínico/estatística & dados numéricos , Técnicas de Laboratório Clínico/estatística & dados numéricos , Testes Diagnósticos de Rotina/estatística & dados numéricos , Notificação de Doenças/normas , Notificação de Doenças/estatística & dados numéricos , Humanos , Laboratórios/classificação , Laboratórios/normas , Inquéritos e Questionários , Estados Unidos
7.
Cancer Cytopathol ; 123(7): 428-34, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25954852

RESUMO

BACKGROUND: Cervical cancer and its precursor lesions are caused by a persistent high-risk human papillomavirus (hrHPV) infection. hrHPV testing has been reported to have higher sensitivity than Papanicolaou (Pap) testing for the detection of cervical precursor lesions. However, limited data are available for prior human papillomavirus (HPV) testing results for patients later diagnosed with invasive cervical cancer, especially in countries lacking a national cervical cancer screening program such as China. This study investigated prior hrHPV testing results for patients with invasive cervical cancer in China. METHODS: Cases with a histologic diagnosis of invasive cervical carcinoma were retrieved from Guangzhou KingMed Diagnostics (the largest independent pathology laboratory in China); prior hrHPV and Pap test results obtained within the year before the cancer diagnosis were recorded. RESULTS: HPV testing was negative in 7.5% of 427 cases of invasive cervical carcinoma, including squamous cell carcinoma (5%) and adenocarcinoma (25%). In 155 cervical cancer cases with prior hrHPV and Pap testing, the negative rate for Pap testing was 1.9%, and the negative rate for HPV was 9.7%. Furthermore, when only cases of adenocarcinoma (n = 18) were examined, both the hrHPV-negative rate and the Pap-negative rate were higher at 33% and 5.6%, respectively. CONCLUSIONS: These data demonstrate a considerable prior hrHPV-negative rate and a lower prior Pap-negative rate in patients with invasive cervical carcinoma (especially adenocarcinoma) from a population of women without access to an established screening program.


Assuntos
Detecção Precoce de Câncer/métodos , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/diagnóstico , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologia , Adenocarcinoma/epidemiologia , Adenocarcinoma/patologia , Adenocarcinoma/virologia , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Bases de Dados Factuais , Feminino , Humanos , Incidência , Laboratórios/classificação , Pessoa de Meia-Idade , Invasividade Neoplásica/patologia , Teste de Papanicolaou , Infecções por Papillomavirus/epidemiologia , Estudos Retrospectivos , Medição de Risco , Neoplasias do Colo do Útero/epidemiologia , Esfregaço Vaginal , Adulto Jovem
8.
PLoS Negl Trop Dis ; 8(9): e3174, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25211336

RESUMO

BACKGROUND: Serological tests have long been established as rapid, simple and inexpensive tools for the diagnosis and follow-up of PCM. However, different protocols and antigen preparations are used and the few attempts to standardize the routine serological methods have not succeeded. METHODOLOGY/PRINCIPAL FINDINGS: We compared the performance of six Brazilian reference centers for serological diagnosis of PCM. Each center provided 30 sera of PCM patients, with positive high, intermediate and low titers, which were defined as the "reference" titers. Each center then applied its own antigen preparation and serological routine test, either semiquantitative double immunodifusion or counterimmmunoelectrophoresis, in the 150 sera from the other five centers blindly as regard to the "reference" titers. Titers were transformed into scores: 0 (negative), 1 (healing titers), 2 (active disease, low titers) and 3 (active disease, high titers) according to each center's criteria. Major discordances were considered between scores indicating active disease and scores indicating negative or healing titers; such discordance when associated with proper clinical and other laboratorial data, may correspond to different approaches to the patient's treatment. Surprisingly, all centers exhibited a high rate of "major" discordances with a mean of 31 (20%) discordant scores. Alternatively, when the scores given by one center to their own sera were compared with the scores given to their sera by the remaining five other centers, a high rate of major discordances was also found, with a mean number of 14.8 sera in 30 presenting a discordance with at least one other center. The data also suggest that centers that used CIE and pool of isolates for antigen preparation performed better. CONCLUSION: There are inconsistencies among the laboratories that are strong enough to result in conflicting information regarding the patients' treatment. Renewed efforts should be promoted to improve standardization of the serological diagnosis of PCM.


Assuntos
Laboratórios/classificação , Paracoccidioidomicose/diagnóstico , Testes Sorológicos/métodos , Idoso , Brasil , Feminino , Humanos , Paracoccidioidomicose/sangue , Paracoccidioidomicose/epidemiologia , Reprodutibilidade dos Testes
10.
Genet Test Mol Biomarkers ; 13(3): 381-6, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19405871

RESUMO

BACKGROUND: The past 10 years have seen an improvement in sequence data quality due to the introduction of capillary sequencers and new sequencing chemistries. In parallel, new software programs for automated mutation detection have been developed. We evaluated the sensitivity of semiautomated unidirectional sequence analysis for the detection of heterozygous base substitutions using the Mutation Surveyor software package. METHODS: Detection rates for heterozygous base substitutions in 29 genes by automated and visual inspection were compared. Examples of heterozygous bases not detected in one direction during bidirectional analysis were also sought through a national survey of United Kingdom (UK) genetics laboratories. Sequence quality was assessed in a consecutive cohort of 50 patients for whom the 39 exons of the ABCC8 gene had been sequenced in one direction. RESULTS: A total of 701 different heterozygous base substitutions were detected by the software with no false negatives (sensitivity >or=99.57%). Four examples of heterozygous bases missed in one direction during bidirectional analysis were reported. Two were detected using unidirectional analysis settings, and the other two bases had low-quality scores. Of the 1950 amplicons examined, 97.2% had a quality score >or=30 and an average PHRED-like score >or=50 for the defined region of interest, and 98.1% of the 323,650 bases had a PHRED score >40. CONCLUSIONS: We found no evidence to support a requirement for bidirectional sequencing. Semiautomated analysis of good quality unidirectional sequence data has high sensitivity and is suitable for heterozygote mutation scanning in clinical diagnostic laboratories. Further work is required to determine minimum quality parameters for semiautomated analysis.


Assuntos
Técnicas de Laboratório Clínico , Análise Mutacional de DNA/métodos , Laboratórios/classificação , Mutação , Software , Transportadores de Cassetes de Ligação de ATP/genética , Sequência de Bases , Estudos de Coortes , Éxons , Mutação da Fase de Leitura , Triagem de Portadores Genéticos , Humanos , Dados de Sequência Molecular , Polimorfismo de Nucleotídeo Único , Canais de Potássio Corretores do Fluxo de Internalização/genética , Receptores de Droga/genética , Sensibilidade e Especificidade , Receptores Sulfonilureia
12.
Ann Biol Clin (Paris) ; 67(2): 233-8, 2009.
Artigo em Francês | MEDLINE | ID: mdl-19297298

RESUMO

Metrology and one of its contributions, metrological traceability represent two fundamental developments for the clinical laboratories. Several international and national institutions take part in these developments. They elaborate recommendations going from concepts to implementation in the clinical laboratories. These activities are helpful for accrediting clinical laboratories.


Assuntos
Academias e Institutos/classificação , Academias e Institutos/normas , Laboratórios/classificação , Terminologia como Assunto , Acreditação , Química Clínica , Europa (Continente) , França , Laboratórios/normas
13.
São Paulo; s.n; 2009. 125 p.
Tese em Português | LILACS | ID: lil-558084

RESUMO

A abordagem sobre a elaboração de índices representativos da qualidade constitui recurso cada vez mais utilizado para o monitoramento ou comparação de uma ou mais situações, permitindo expressar de forma simplificada as condições avaliadas. Na área de meio ambiente, os resultados fornecidos pelos laboratórios de controle ambiental assumem um importante papel, proporcionando situações de julgamento e decisão por parte de quem utiliza esses resultados, pois o mérito dessas decisões pode ser influenciado pela qualidade desses resultados. Para tanto, objetivou-se propor um índice de qualidade aplicável a laboratórios de controle ambiental, avaliando a sua representatividade, a realidade do laboratório com base no seu histórico de qualidade e aplicabilidade do índice no acompanhamento de condições gerais de desempenho. A pesquisa, de caráter exploratório, foi constituída a partir da seleção de dez especialistas em laboratórios de controle ambiental, representantes dos setores público, privado e academia, entrevistados nas sucessivas etapas de proposição do índice. A primeira etapa constituiu entrevista aos especialistas com uso da técnica de Brainstorming que culminou com a seleção de vinte parâmetros de consulta. Nas etapas seguintes, seguiram-se os preceitos da técnica DELPHI para extrair e refinar os julgamentos do grupo, bem como, selecionar os parâmetros finais de avaliação do IQL, critérios de pontuação e as três faixas de enquadramento dos laboratórios (inadequada, em fase de adequação ou adequada). Foram realizados experimentos de aplicação do IQL em seis laboratórios de controle ambiental, também representantes dos setores público, privado e da academia, a razão de duas unidades por setor, dentre os quais se encontravam laboratórios acreditados pelo INMETRO, conforme a norma ISO IEC 17.025. A experiência na prática laboratorial revelou que o IQL poderá ser utilizado como ferramenta de apoio a pré-qualificação de laboratórios ambientais prestadores de serv...


Assuntos
Meio Ambiente , Indicadores Ambientais , Qualidade Ambiental , Normas de Qualidade Ambiental , Laboratórios/classificação , Laboratórios/organização & administração , Monitoramento Ambiental/instrumentação
14.
Zhongguo Yi Liao Qi Xie Za Zhi ; 31(4): 248-52, 2007 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-17969504

RESUMO

OBJECTIVE: To identify and generalize classes of public health laboratory detection activities and to discuss the method of identification and generalization of classes of Public Health Conceptual Information Model. METHODS: At first, materials should be collected from consulting literatures and experts, referring to the existing system. Then, identification and generalization of classes are got for business process analysis, writing description documents, summing up important conceptions and activities, By use-case analysis, use-case diagram and tabulation of important conception and activities and reference to PHCDM, a structural diagram of classes is constructed. RESULTS: A structure diagram of classes of public health laboratory detection activity is given. CONCLUSIONS: This is a feasible method in identification and generalization of classes of public health laboratory detection activities.


Assuntos
Laboratórios/classificação , Modelos Organizacionais , Saúde Pública
15.
Med Pr ; 57(4): 353-8, 2006.
Artigo em Polonês | MEDLINE | ID: mdl-17133916

RESUMO

Laboratory workers are at a particularly high risk of acquiring HIV. Based on the medical literature, selected cases of occupational HIV infections among laboratory workers are presented. Having analyzed specific circumstances connected with occupational exposures, risk factors of such incidents are discussed. The importance of continuing education in the areas of infection control procedures and compliance with universal precautions as well as reporting on occupational exposures to any infectious material in the context of post-exposure prophylaxis are pointed as the best ways to achieve a successful outcome in the HIV infection prevention under laboratory conditions. The lack of efficient, multifaceted legislation covering all aspects of occupational exposure to blood-borne pathogens, still observed in Poland, is stressed.


Assuntos
Infecções por HIV/transmissão , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Exposição Ocupacional/prevenção & controle , Recursos Humanos em Hospital , Patógenos Transmitidos pelo Sangue/isolamento & purificação , Feminino , Infecções por HIV/prevenção & controle , Infecções por HIV/virologia , Humanos , Laboratórios/classificação , Masculino , Ferimentos Penetrantes Produzidos por Agulha/complicações , Ferimentos Penetrantes Produzidos por Agulha/prevenção & controle , Doenças Profissionais/prevenção & controle , Doenças Profissionais/virologia , Polônia , Prevalência , Fatores de Risco , Comportamento de Redução do Risco , Precauções Universais/métodos
16.
Scand J Work Environ Health ; 31(2): 108-14, 2005 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-15864904

RESUMO

OBJECTIVES: The Danish National Birth Cohort was used to examine whether laboratory work was associated with reduced fecundity. METHODS: Self-reported data on laboratory work and waiting time to pregnancy (0-2, 3-5, 6-12 and > 12 months) were used for 829 female laboratory technicians interviewed in 1997-2003. Altogether 6250 female teachers formed the reference group. A discrete-time survival analysis with a complementary log-log link was applied to estimate the fecundability ratio between the exposed and unexposed women, with adjustment for maternal age, gravidity, smoking, prepregnancy body mass index, and paternal job. RESULTS: No difference in time to pregnancy was found between the laboratory technicians and teachers or between the laboratory technicians with different exposures. The adjusted fecundability ratio for the laboratory technicians was 0.94 [95% confidence interval (95% CI) 0.86-1.02] for all pregnancies and 0.98 (95% CI 0.86-1.13) for first pregnancies. A healthy worker effect was found for the laboratory technicians working with the work processes under study. CONCLUSIONS: The results do not suggest that laboratory work in Denmark at present impairs female fecundity.


Assuntos
Fertilidade/efeitos dos fármacos , Pessoal de Laboratório Médico/estatística & dados numéricos , Exposição Ocupacional/análise , Adulto , Estudos de Coortes , Dinamarca/epidemiologia , Docentes/estatística & dados numéricos , Serviços de Planejamento Familiar , Feminino , Humanos , Laboratórios/classificação , Pessoal de Laboratório Médico/classificação , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/estatística & dados numéricos , Gravidez , Segundo Trimestre da Gravidez , Medição de Risco , Fatores de Risco , Análise e Desempenho de Tarefas , Fatores de Tempo
20.
São Paulo; s.n; 2003. 130 p. ilus, tab, graf.
Tese em Português | LILACS | ID: lil-409023

RESUMO

O estudo foi realizado com a participação de 120 trabalhadores da Divisão de Laboratório Central do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, com o objetivo de determinar associações de fatores demográficos, história clínica e ocupacional, estresse relacionado ao trabalho e fatores ergonômicos, com relatos de sintomas osteomusculares e faltas ao trabalho relacionadas aos sintomas. Os sintomas apresentaram associação significante com a história pregressa de doenças reumáticas ou ortopédicas e com posturas e movimentos inadequados na realização do trabalho. As faltas ao trabalho em função dos sintomas foram associadas ao baixo grau de escolaridade e ao estado civil dos trabalhadores.This study was developed with 120 workers of the Central Laboratory Division of "Hospital das Clínicas", University of São Paulo - School of Medicine, with the objective of determining the association of demographic factors, clinical and occupational case history, work related stress and ergonomic workplace analysis with the outcomes: musculoskeletal symptoms and related absences from work. The symptoms have been significantly associated with previous history of rheumatic or orthopedic disease and with inadequate movements and postures at work. The absences from work due to musculoskeletal symptoms have been significantly associated with the workers' low level of education and marital status...


Assuntos
Humanos , Masculino , Feminino , Adulto , Doenças Profissionais/epidemiologia , Laboratórios/classificação , Pessoal de Laboratório/estatística & dados numéricos , Estresse Fisiológico , Transtornos Traumáticos Cumulativos/epidemiologia , Absenteísmo , Características da População , Ergonomia , Fatores de Risco
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